Bionic skin repair cream and preparation method thereof

Abstract

The present invention discloses a method for preparing a bionic skin repair cream, comprising preparing an oil phase, a silicone oil phase, and an aqueous phase, homogenizing the aqueous phase, directly adding the oil phase and the silicone oil phase under homogenization conditions to obtain an emulsion, controlling the external temperature to 25-28°C, mechanically stirring to cool to 35-45°C, adding a loaded onion extract and a preservative, and continuing to stir until the temperature reaches room temperature, wherein the loaded onion extract is an onion extract using hydrophobically modified mesoporous silica as a carrier, to obtain a bionic skin repair cream. The present invention obtains a repair cream with uniform emulsification and high stability, which has a typical lamellar liquid crystal structure similar to the structure of the human stratum corneum and thus has functions similar to the stratum corneum, protecting the skin and repairing damaged skin, and has broad application prospects in the field of skin care.

Description

Technical Field

[0001] The present invention relates to the technical field of repair creams, and in particular to a bionic skin repair cream and a preparation method thereof. Background Art

[0002] Currently, due to factors such as environmental pollution, mental stress, and excessive use of cosmetics, the number of people with sensitive skin is gradually increasing. The main factors contributing to sensitive skin include endogenous susceptibility factors and exogenous irritants. Endogenous susceptibility factors include race, age, gender, genetics, and medical conditions; exogenous irritants include environmental factors, chemical factors, and lifestyle. Some people in this group have a damaged skin barrier, which disrupts the water-oil balance in the epidermis. The most obvious manifestations are a thin stratum corneum, dry skin, a damaged skin barrier, and poor water retention. This can lead to oily skin, clogged pores, and enlarged pores. For this group, a repair-focused treatment combined with moisturizing and soothing effects should be used.

[0003] Repair cream is a kind of ointment-like cosmetic that has the function of repairing the skin. It has good moisturizing and moisturizing effects and can keep the skin moisturized. As a commonly used cosmetic dosage form, repair cream has obvious efficacy, few side effects on the skin, and is easy to use. The market prospects are getting better and better. At the same time, in order to achieve the effect of repairing skin damage, natural ingredients with significant repair effects are often added to repair cream as skin repair factors. Natural plant extracts are pollution-free, hormone-free, and residue-free, and have diverse functions, wide applicability, and safety. Therefore, they have considerable research and development enthusiasm in the field of cosmetics research.

[0004] Onion extract, a volatile oil rich in allicin, thiols, and trisulfides, also contains caffeic acid, sinapic acid, cinnamic acid, citrate, polysaccharides, and various amino acids. It not only has anti-inflammatory and antibacterial properties but also promotes wound healing. The use of onion extract in repair creams holds great research potential. However, currently, the biocompatibility between natural plant-derived onion extract and conventional emulsifiers is poor, making its application in repair creams ineffective in generating the synergistic effects needed to enhance the repairing properties. Summary of the Invention

[0005] The purpose of the present invention is to solve the shortcomings of the prior art and to propose a bionic skin repair cream and a preparation method thereof.

[0006] The present invention discloses a method for preparing a bionic skin repair cream, comprising the following steps:

[0007] a. Weigh the following raw materials in parts by weight and mix them evenly to obtain an oil phase, which is then preheated in a constant temperature water bath at 75-80°C;

[0008] 3-6 parts of liquid crystal emulsifier,

[0009] 5-20 parts of oil;

[0010] b. Weigh the following raw materials in parts by weight and mix them evenly to obtain a silicone oil phase;

[0011] 10-20 parts of polydimethylsiloxane,

[0012] 0.5-2 parts of silanol;

[0013] c. Weigh the following raw materials in parts by weight and mix them evenly to obtain an aqueous phase, which is then preheated in a constant temperature water bath at 75-80°C;

[0014] Thickener 0.1-0.5 parts,

[0015] 3-30 parts of water-soluble active ingredients,

[0016] Add water to 100 parts;

[0017] d. Homogenize the aqueous phase, directly add the oil phase and silicone oil phase under homogenization conditions, and homogenize for 5-8 minutes to obtain an emulsion;

[0018] e. Take the emulsion out of the constant temperature water bath, control the external temperature to 25-28°C, mechanically stir at a speed of 300-500 r / min to cool down to 35-45°C, add the loaded onion extract and 0.1-0.5 parts of preservatives and continue stirring to room temperature. The mass ratio of onion extract to polydimethylsiloxane in the loaded onion extract is 5-15:10-20 to obtain a bionic skin repair cream.

[0019] Preferably, the loaded onion extract is an onion extract using hydrophobically modified mesoporous silica as a carrier.

[0020] Preferably, the loaded onion extract is prepared according to the following steps: adding polyvinyl pyrrolidone to a sodium hydroxide solution and stirring, adding hexadecyltrimethylammonium bromide, adding ethyl orthosilicate dropwise thereto after stirring, stirring, filtering, washing, and drying in sequence, sending it into a high-temperature furnace of 500-600°C for calcination, cooling, crushing, adding it to toluene, adding 3-aminopropyltriethoxysilane thereto, ultrasonicating, filtering, washing, and drying in sequence, adding onion extract and deionized water thereto, ultrasonicating, and spray drying to obtain the loaded onion extract.

[0021] Preferably, the mass ratio of polyvinyl pyrrolidone, hexadecyltrimethylammonium bromide, ethyl orthosilicate, 3-aminopropyltriethoxysilane and onion extract is 0.1-1:1-2:10-20:0.1-1:5-15.

[0022] The present invention adopts a compound of polyvinyl pyrrolidone and hexadecyltrimethylammonium bromide as a template, and ethyl orthosilicate is deposited on the surface of the template, thereby forming a shell layer with a cavity inside and mesoporous channels evenly distributed on the surface. After high-temperature calcination, a mesoporous material with rich silicon hydroxyl groups on the surface is formed. At the same time, since short-chain alkyl groups are connected to the mesoporous surface, the mesoporous material can be transformed from hydrophilic to hydrophobic, which not only can fully adsorb the onion extract, but also the water-soluble functional ingredients in the aqueous phase can gradually enter the mesoporous channels through molecular movement and be fixed by electrostatic interaction with the silicon hydroxyl groups on the inner wall of the channel. The combined effect allows the onion extract to be fully dispersed at the oil-water interface. On the one hand, it can effectively enhance the stability of the emulsion and improve the synergistic effect of the repair effect. On the other hand, in conjunction with the action of carboxymethyl chitosan, the carboxymethyl chitosan introduces a large number of hydroxyl groups into the system, so that a large number of hydrogen bonds appear in the system. The existence of this non-covalent force gives the system a certain self-healing ability, further enhancing the stability of the emulsion.

[0023] Preferably, the liquid crystal emulsifier includes at least one of a lecithin liquid crystal emulsifier, a glycoside emulsifier, and a higher fatty alcohol emulsifier.

[0024] Preferably, the higher fatty alcohol emulsifier is at least one of cetyl alcohol, stearyl alcohol, cetearyl alcohol, and behenyl alcohol.

[0025] Preferably, the oil comprises at least one of saturated isopropyl myristate, isooctyl palmitate, caprylic / capric triglyceride, shea butter, and squalane.

[0026] Preferably, the water-soluble effective ingredients include at least one of water-soluble vitamins, water-soluble bisabolol, ectoine, and dipotassium glycyrrhizate.

[0027] Preferably, during the homogenization of the aqueous phase, the homogenization rate is 5000-9000 r / min.

[0028] Preferably, the thickener is at least one of xanthan gum, cellulose ether and polyacrylamide.

[0029] Preferably, the cellulose ether is at least one of 250HBR cellulose ether, 250HHBR cellulose ether, NATROSOLHE 10K cellulose ether, and hecellose B 30K cellulose ether.

[0030] Preferably, the preservative is at least one of p-hydroxyacetophenone and polyol.

[0031] A bionic skin repairing cream is prepared by adopting the preparation method of the bionic skin repairing cream.

[0032] The technical effects of the present invention are as follows:

[0033] This invention uses onion extract and polydimethylsiloxane as main ingredients and liquid crystal emulsification technology to prepare a bionic skin repair cream. The onion extract can reduce inflammation, kill bacteria, and promote wound healing. It can also inhibit the growth of fibroblasts, thereby preventing scar formation. The polydimethylsiloxane can lubricate the skin, soften the cuticle, and make it more supple. It also resists ultraviolet rays, has good air permeability, and is dust-proof. It can also form a layer on the surface of scars that acts like a stratum corneum, changing the microenvironment for scar growth and inhibiting scarring.

[0034] Since onion extract is rich in allicin, thiols, trisulfides, caffeic acid, sinapic acid, cinnamic acid, citrate, polysaccharides, and various amino acids, its composition is complex and contains both hydrophilic and lipophilic components. Therefore, the onion extract is prepared using hydrophobically modified mesoporous silica as a carrier, which can fully adsorb the hydrophilic and lipophilic components in the onion extract and effectively promote the uniform dispersion of the onion extract in the system.

[0035] In the liquid crystal biomimetic system of the present invention, emulsifier molecules are oriented at the oil-water interface to form a lamellar liquid crystal structure. This structure not only contains a large amount of bound water but also has a hydrophobic continuous phase, which allows it to dissolve various functional ingredients and maintain their activity. It also exhibits excellent water-locking and moisturizing properties, significant sustained release, good visual quality, and excellent skin feel, significantly improving product performance and effectively resolving skin problems. The present invention is a typical lamellar liquid crystal structure, similar to the structure of the human stratum corneum, and thus has similar functions to the stratum corneum, protecting the skin and repairing damaged skin, and has broad application prospects in the field of skin care.

[0036] The present invention obtains a repair cream with uniform emulsification, delicate skin feel and high stability, good permeability, faster absorption, and can improve the utilization rate of repair active components. It has obvious moisturizing and penetration effects and no allergenic phenomenon. After use, it can effectively smooth fine lines, reduce dry lines and wrinkles, slow down skin aging, and effectively improve dryness and sagging, making the skin hydrated, smooth and elastic. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 This is a polarizing microscope image of the bionic skin repair cream obtained in Example 5.

[0038] Figure 2 This is a comparison chart of the effects of the bionic skin repair cream obtained in Example 4 before and after use.

[0039] Figure 3 This is a comparison chart of the effects of the bionic skin repair cream obtained in Example 5 before and after use. DETAILED DESCRIPTION

[0040] The present invention will be further explained below with reference to specific embodiments.

[0041] Example 1

[0042] A method for preparing a bionic skin repair cream comprises the following steps:

[0043] a. Weigh the following raw materials by weight and mix them evenly to obtain an oil phase, which is then preheated in a constant temperature water bath at 78°C;

[0044] 3kg of lecithin liquid crystal emulsifier,

[0045] Saturated isopropyl myristate 5kg;

[0046] b. Weigh the following raw materials and mix them evenly to obtain a silicone oil phase;

[0047] Polydimethylsiloxane 10kg,

[0048] 0.5 kg of silanol;

[0049] c. Weigh the following raw materials and mix them evenly to obtain an aqueous phase, which is then preheated in a constant temperature water bath at 75°C;

[0050] Xanthan gum 0.1kg,

[0051] 3kg of water-soluble vitamins,

[0052] Add purified water to 100kg;

[0053] d. Homogenize the aqueous phase at a speed of 5000 r / min, directly add the oil phase and silicone oil phase under homogenization conditions, and homogenize for 5 minutes to obtain an emulsion;

[0054] e. Take the emulsion out of the constant temperature water bath, control the external temperature to 25°C, and mechanically stir at a speed of 300 r / min to cool it to 35°C. Then, add 5 kg of onion extract and 0.1 kg of p-hydroxyacetophenone and continue stirring until it reaches room temperature to obtain a bionic skin repair cream.

[0055] Example 2

[0056] A method for preparing a bionic skin repair cream comprises the following steps:

[0057] a. Weigh the following raw materials by weight and mix them evenly to obtain an oil phase, which is then preheated in a constant temperature water bath at 80°C;

[0058] 6kg of glycoside emulsifier,

[0059] 20kg of 2-ethylhexyl palmitate;

[0060] b. Weigh the following raw materials and mix them evenly to obtain a silicone oil phase;

[0061] Polydimethylsiloxane 20kg,

[0062] 2kg of silanol;

[0063] c. Weigh the following raw materials and mix them evenly to obtain an aqueous phase, which is then preheated in a constant temperature water bath at 80°C;

[0064] Xanthan gum 0.5kg,

[0065] Water-soluble bisabolol 30kg,

[0066] Add purified water to 100kg;

[0067] d. Homogenize the aqueous phase at a speed of 6000 r / min, directly add the oil phase and silicone oil phase under homogenization conditions, and homogenize for 8 minutes to obtain an emulsion;

[0068] e. Take the emulsion out of the constant temperature water bath, control the external temperature to 28°C, mechanically stir at a speed of 500 r / min to cool to 45°C, add 15 kg of onion extract and 0.5 kg of dipropylene glycol and continue stirring to room temperature to obtain a bionic skin repair cream.

[0069] Example 3

[0070] A method for preparing a bionic skin repair cream comprises the following steps:

[0071] a. Weigh the following raw materials by weight and mix them evenly to obtain an oil phase, which is then preheated in a constant temperature water bath at 76°C;

[0072] 4kg of stearyl alcohol,

[0073] Isooctyl palmitate 10kg;

[0074] b. Weigh the following raw materials and mix them evenly to obtain a silicone oil phase;

[0075] Polydimethylsiloxane 12kg,

[0076] silanol 0.8 kg;

[0077] c. Weigh the following raw materials and mix them evenly to obtain an aqueous phase, which is then preheated in a constant temperature water bath at 76°C;

[0078] 250HBR cellulose ether 0.2kg,

[0079] Dipotassium glycyrrhizate 10kg,

[0080] Add purified water to 100kg;

[0081] d. Homogenize the aqueous phase, directly add the oil phase and silicone oil phase under homogenization conditions, and homogenize for 6 minutes to obtain an emulsion;

[0082] e. Take the emulsion out of the constant temperature water bath, control the external temperature to 25°C, and mechanically stir at a speed of 350 r / min to cool to 36°C. Then, add the loaded onion extract and 0.2 kg of dipropylene glycol and continue stirring to room temperature to obtain a bionic skin repair cream.

[0083] The loaded onion extract was prepared according to the following specific steps: 0.1 kg of polyvinyl pyrrolidone was added to 30 kg of 0.1 mol / L sodium hydroxide solution and stirred evenly, 1 kg of hexadecyltrimethylammonium bromide was added and stirring was continued for 1 hour at a stirring speed of 1000 r / min, 15 kg of ethyl orthosilicate was added dropwise thereto under stirring, stirring was continued for 1 hour, filtered, washed twice with ethanol, dried, sent to a 500°C high-temperature furnace for calcination for 5 hours, cooled to room temperature, crushed, added to 20 kg of toluene, 0.1 kg of 3-aminopropyltriethoxysilane was added thereto under stirring, ultrasonically treated for 1 hour, filtered, washed twice with ethanol, vacuum dried, 5 kg of onion extract and 10 kg of deionized water were added thereto, ultrasonically treated for 1 hour, and spray-dried to obtain the loaded onion extract.

[0084] Example 4

[0085] A method for preparing a bionic skin repair cream comprises the following steps:

[0086] a. Weigh the following raw materials by weight and mix them evenly to obtain an oil phase, which is then preheated in a constant temperature water bath at 78°C;

[0087] 5kg of behenyl alcohol,

[0088] 18kg shea butter;

[0089] b. Weigh the following raw materials and mix them evenly to obtain a silicone oil phase;

[0090] Polydimethylsiloxane 18kg,

[0091] 1.5 kg of silanol;

[0092] c. Weigh the following raw materials and mix them evenly to obtain an aqueous phase, which is then preheated in a constant temperature water bath at 79°C;

[0093] NATROSOLHE 10K cellulose ether 0.4kg,

[0094] 25kg of dipotassium glycyrrhizate,

[0095] Add purified water to 100kg;

[0096] d. Homogenize the aqueous phase, directly add the oil phase and silicone oil phase under homogenization conditions, and homogenize for 7 minutes to obtain an emulsion;

[0097] e. Take the emulsion out of the constant temperature water bath, control the external temperature to 28°C, and cool it down to 45°C by mechanical stirring at a speed of 500 r / min. Then, add the loaded onion extract and 0.5 kg of p-hydroxyacetophenone and continue stirring to room temperature to obtain a bionic skin repair cream.

[0098] In the loaded onion extract, 1 kg of polyvinyl pyrrolidone was added to 50 kg of 0.2 mol / L sodium hydroxide solution and stirred evenly. 2 kg of hexadecyltrimethylammonium bromide was added and stirring was continued for 2 h at a stirring speed of 5000 r / min. 15 kg of ethyl orthosilicate was added dropwise thereto under stirring, and stirring was continued for 2 h. The mixture was filtered, washed with ethanol 4 times, dried, and sent to a 600 ° C high-temperature furnace for calcination for 15 h. The mixture was cooled to room temperature, crushed, and added to 40 kg of toluene. 1 kg of 3-aminopropyltriethoxysilane was added thereto under stirring, ultrasonically treated for 2 h, filtered, washed with ethanol 4 times, vacuum dried, 15 kg of onion extract and 30 kg of deionized water were added thereto, ultrasonically treated for 2 h, and spray-dried to obtain the loaded onion extract.

[0099] Apply the bionic skin repair cream obtained in this example to the skin erythema three times a day, morning, noon and evening, for two days. The effect is as follows: Figure 2 shown.

[0100] Example 5

[0101] A method for preparing a bionic skin repair cream comprises the following steps:

[0102] a. Weigh the following raw materials by weight and mix them evenly to obtain an oil phase, which is then preheated in a constant temperature water bath at 78°C;

[0103] Liquid crystal emulsifier 5kg,

[0104] Squalane 10kg;

[0105] The liquid crystal emulsifier comprises hydrogenated lecithin and cetearyl alcohol in a weight ratio of 1:1;

[0106] b. Weigh the following raw materials and mix them evenly to obtain a silicone oil phase;

[0107] Polydimethylsiloxane 15kg,

[0108] 1.2 kg of silanol;

[0109] c. Weigh the following raw materials and mix them evenly to obtain an aqueous phase, which is then preheated in a constant temperature water bath at 78°C;

[0110] 250HHBR cellulose ether 0.3kg,

[0111] Ectoin 20kg,

[0112] Add purified water to 100kg;

[0113] d. Homogenize the aqueous phase at a speed of 5000 r / min, directly add the oil phase and silicone oil phase under homogenization conditions, and homogenize for 6 minutes to obtain an emulsion;

[0114] e. Take the emulsion out of the constant temperature water bath, control the external temperature to 26°C, and mechanically stir at a speed of 400 r / min to cool down to 40°C. Then, add the loaded onion extract and 0.3 kg of p-hydroxyacetophenone and continue stirring to room temperature to obtain a bionic skin repair cream.

[0115] The loaded onion extract was prepared according to the following specific steps: 0.5 kg of polyvinyl pyrrolidone was added to 40 kg of 0.12 mol / L sodium hydroxide solution and stirred evenly, 1.5 kg of hexadecyltrimethylammonium bromide was added and stirring was continued for 1.5 hours at a stirring speed of 3000 r / min, 10 kg of ethyl orthosilicate was added dropwise thereto under stirring, stirring was continued for 1.5 hours, filtered, washed with ethanol three times, dried, sent to a 550°C high-temperature furnace for calcination for 10 hours, cooled to room temperature, crushed, added to 30 kg of toluene, 0.5 kg of 3-aminopropyltriethoxysilane was added thereto under stirring, ultrasonically treated for 1.5 hours, filtered, washed with ethanol three times, vacuum dried, 10 kg of onion extract and 20 kg of deionized water were added thereto, ultrasonically treated for 1.5 hours, and spray-dried to obtain the loaded onion extract.

[0116] The bionic skin repair cream obtained in this example was placed under a polarizing microscope for observation. Figure 1 As shown, it can be seen that: in the obtained bionic skin repair cream, the emulsifier molecules at the oil-water interface are oriented to form a lamellar liquid crystal structure, which is a typical lamellar liquid crystal structure and is emulsified uniformly.

[0117] Apply the bionic skin repair cream obtained in this example to the skin erythema three times a day, morning, noon and evening, for two days. The effect is as follows: Figure 3 shown.

[0118] Comparative Example 1

[0119] A method for preparing a skin repair cream comprises the following steps:

[0120] a. Weigh the following raw materials by weight and mix them evenly to obtain an oil phase, which is then preheated in a constant temperature water bath at 78°C;

[0121] Liquid crystal emulsifier 5kg,

[0122] Squalane 10kg;

[0123] The liquid crystal emulsifier comprises hydrogenated lecithin and cetearyl alcohol in a weight ratio of 1:1;

[0124] b. Weigh the following raw materials and mix them evenly to obtain a silicone oil phase;

[0125] Polydimethylsiloxane 15kg,

[0126] 1.2 kg of silanol;

[0127] c. Weigh the following raw materials and mix them evenly to obtain an aqueous phase, which is then preheated in a constant temperature water bath at 78°C;

[0128] 250HHBR cellulose ether 0.3kg,

[0129] Ectoin 20kg,

[0130] Add purified water to 100kg;

[0131] d. Homogenize the aqueous phase at a speed of 5000 r / min, directly add the oil phase and silicone oil phase under homogenization conditions, and homogenize for 6 minutes to obtain an emulsion;

[0132] e. Take the emulsion out of the constant temperature water bath, control the external temperature to 26°C, and mechanically stir at a speed of 400 r / min to cool down to 40°C. Then, add the loaded onion extract and 0.3 kg of p-hydroxyacetophenone and continue stirring to room temperature to obtain a skin repair cream.

[0133] The loaded onion extract was prepared according to the following specific steps: 0.5 kg of polyvinyl pyrrolidone was added to 40 kg of 0.12 mol / L sodium hydroxide solution and stirred evenly, 1.5 kg of hexadecyltrimethylammonium bromide was added and stirring was continued for 1.5 hours at a stirring speed of 3000 r / min, 10 kg of ethyl orthosilicate was added dropwise thereto under stirring, stirring was continued for 1.5 hours, filtered, washed with ethanol three times, dried, and sent to a high-temperature furnace at 550° C. for calcination for 10 hours, cooled to room temperature, crushed, 10 kg of onion extract and 20 kg of deionized water were added, ultrasonically treated for 1.5 hours, and spray-dried to obtain the loaded onion extract.

[0134] Comparative Example 2

[0135] A method for preparing a skin repair cream comprises the following steps:

[0136] a. Weigh the following raw materials by weight and mix them evenly to obtain an oil phase, which is then preheated in a constant temperature water bath at 78°C;

[0137] Liquid crystal emulsifier 5kg,

[0138] Squalane 10kg;

[0139] The liquid crystal emulsifier comprises hydrogenated lecithin and cetearyl alcohol in a weight ratio of 1:1;

[0140] b. Weigh the following raw materials and mix them evenly to obtain a silicone oil phase;

[0141] Polydimethylsiloxane 15kg,

[0142] 1.2 kg of silanol;

[0143] c. Weigh the following raw materials and mix them evenly to obtain an aqueous phase, which is then preheated in a constant temperature water bath at 78°C;

[0144] 250HHBR cellulose ether 0.3kg,

[0145] Ectoin 20kg,

[0146] Add purified water to 100kg;

[0147] d. Homogenize the aqueous phase at a speed of 5000 r / min, directly add the oil phase and silicone oil phase under homogenization conditions, and homogenize for 6 minutes to obtain an emulsion;

[0148] e. Take the emulsion out of the constant temperature water bath, control the external temperature to 26°C, and mechanically stir at a speed of 400 r / min to cool it down to 40°C. Then, add onion extract and 0.3 kg of p-hydroxyacetophenone and continue stirring until the temperature reaches room temperature to obtain a skin repair cream.

[0149] The products of Example 5 and Comparative Examples 1-2 were subjected to stability tests, wherein the stability test method was based on the industry standard "QB / T1857-2004 Moisturizing Creams".

[0150] The specific method is: place it at -15℃ and 28℃ for 90 days or after three cycles of hot and cold treatment, observe whether there is oil phase precipitation. The three cycles of hot and cold treatment are alternately cycled at -15℃ to 28℃, with each temperature cycle interval of 24 hours. The test results are shown in the following table:

[0151] Test items Example 5 Comparative Example 1 Comparative Example 2 -15℃ Stablize Stablize Stablize 28℃ Stablize Trace precipitation Trace precipitation Hot and cold cycles Stablize Trace precipitation Large amount of precipitation

[0152] As can be seen from the above table, the repair cream obtained in Example 5 shows better emulsification stability, and it can be seen from observation that it has good lifting and spreading properties.

[0153] 60 healthy Chinese female subjects aged 20-40 years with dry, rough, scaly skin, self-identified skin sensitivity, and positive lactic acid stimulation reaction were selected and divided into three groups, 20 in each group, and used the repair cream obtained in Example 5 and Comparative Examples 1-2 respectively.

[0154] The moisture content of the cheek stratum corneum, transepidermal water loss, and skin erythema index were measured before and after two weeks of continuous use of the test product. The test site was the cheek, where:

[0155] Stratum corneum moisture content: Use Corneometer to test the stratum corneum moisture content; the higher the value, the higher the stratum corneum moisture content, and the better the product's hydrating and moisturizing effect.

[0156] Transepidermal water loss: Detected using the TewameterTM300 skin surface water loss tester; the lower the value, the less transepidermal water loss, and the better the product's effect in reducing transepidermal water loss and repairing the skin barrier.

[0157] Skin erythema index EI value: tested using the skin melanin and hemoglobin tester MexameterMX18; the lower the measured value, the lower the skin erythema index, and the better the product's effect in soothing the skin and reducing skin erythema and redness.

[0158] Change rate (%) = (data after use - data before use) / data before use × 100%.

[0159] The test results are shown in the following table:

[0160] Test items Example 5 Comparative Example 1 Comparative Example 2 Change rate of stratum corneum water content / % 27.45 16.37 15.41 Transepidermal water loss change rate / % -6.12 -4.65 -4.11 Change rate of skin erythema index EI value / % -6.32 -4.85 -4.35

[0161] As can be seen from the above table, after using the repair cream obtained in Example 5, the change rate of stratum corneum water content, the change rate of transepidermal water loss, and the change rate of skin erythema index EI value are significantly higher than those of using Comparative Example 2, indicating that the repair cream obtained in the present invention has the effects of moisturizing, repairing the skin barrier, and improving skin erythema and redness.

[0162] The above description is only a preferred specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any technician familiar with the technical field, within the technical scope disclosed by the present invention, who makes equivalent replacements or changes based on the technical solution and inventive concept of the present invention, should be covered by the scope of protection of the present invention.

Claims

1. A method for preparing a bionic skin repair cream, characterized in that: The steps include: a. Weigh the following raw materials in parts by weight and mix them evenly to obtain an oil phase, which is then preheated in a constant temperature water bath at 75-80°C; 3-6 parts of liquid crystal emulsifier, 5-20 parts of oil; b. Weigh the following raw materials in parts by weight and mix them evenly to obtain a silicone oil phase; 10-20 parts of polydimethylsiloxane, 0.5-2 parts of silanol; c. Weigh the following raw materials in parts by weight and mix them evenly to obtain an aqueous phase, which is then preheated in a constant temperature water bath at 75-80°C; Thickener 0.1-0.5 parts, 3-30 parts of water-soluble active ingredients, Add water to 100 parts; d. Homogenize the aqueous phase, directly add the oil phase and silicone oil phase under homogenization conditions, and homogenize for 5-8 minutes to obtain an emulsion; e. Remove the emulsion from the constant temperature water bath, control the external temperature to 25-28°C, mechanically stir at a speed of 300-500 r / min to cool to 35-45°C, add the loaded onion extract and 0.1-0.5 parts of preservatives, and continue stirring until the temperature reaches room temperature. The mass ratio of onion extract to polydimethylsiloxane in the loaded onion extract is 5-15:10-20, to obtain a bionic skin repair cream; The loaded onion extract is an onion extract using hydrophobically modified mesoporous silica as a carrier.

2. The method for preparing the bionic skin repair cream according to claim 1, characterized in that: The loaded onion extract is prepared according to the following steps: adding polyvinyl pyrrolidone to a sodium hydroxide solution and stirring, adding hexadecyltrimethylammonium bromide, adding ethyl orthosilicate dropwise thereto after stirring, stirring, filtering, washing, and drying in sequence, sending the solution into a high-temperature furnace of 500-600 DEG C for calcination, cooling, crushing, adding toluene, and then adding 3-aminopropyltriethoxysilane thereto, ultrasonicating, filtering, washing, and drying in sequence, then adding the onion extract and deionized water, ultrasonicating, and spray drying to obtain the loaded onion extract.

3. The method for preparing the bionic skin repair cream according to claim 2, characterized in that: The mass ratio of polyvinyl pyrrolidone, hexadecyltrimethylammonium bromide, ethyl orthosilicate, 3-aminopropyltriethoxysilane and onion extract is 0.1-1:1-2:10-20:0.1-1:5-15.

4. The method for preparing the bionic skin repairing cream according to claim 1, characterized in that: The liquid crystal emulsifier includes at least one of a lecithin liquid crystal emulsifier, a glycoside emulsifier, and a higher fatty alcohol emulsifier.

5. The method for preparing the bionic skin repairing cream according to claim 1, characterized in that: The oil comprises at least one of saturated isopropyl myristate, isooctyl palmitate, caprylic / capric triglyceride, shea butter, and squalane.

6. The method for preparing the bionic skin repairing cream according to claim 1, characterized in that: The water-soluble functional ingredients include at least one of water-soluble vitamins, water-soluble bisabolol, ectoine, and dipotassium glycyrrhizate.

7. The method for preparing the bionic skin repairing cream according to claim 1, characterized in that: Homogenize the aqueous phase at a homogenization rate of 5000-9000 r / min.

8. A bionic skin repair cream, characterized in that: The bionic skin repair cream is prepared by the preparation method of any one of claims 1 to 7.

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