A quality control method for an anti-inflammatory and analgesic composition
By using the Yuss chamber transdermal assay and high performance liquid chromatography to detect the transdermal components of the anti-inflammatory and analgesic tincture, the deficiencies in the quality control of the anti-inflammatory and analgesic tincture were resolved, and effective monitoring of transdermal components and product quality stability were achieved.
CN117214316BActive Publication Date: 2026-01-06GUANGXI HUAHONG PHARM CO LTD
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Patent Information
- Application Number
- CN202310983066.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-08-07
- Publication Date
- 2026-01-06
- Estimated Expiration
- 2043-08-07
AI Technical Summary
Technical Problem
There is limited research on the transdermal absorption of anti-inflammatory and analgesic tinctures, and effective quality control methods are lacking.
Method used
A novel quality control method was established by using the Yuss chamber transdermal assay combined with high performance liquid chromatography (HPLC) to extract transdermal components from isolated rat skin and detect these components using HPLC.
Benefits of technology
This enables effective monitoring of the transdermal components of the anti-swelling and analgesic tincture, ensuring the stability and uniformity of product quality, preventing counterfeiting, and maintaining production and distribution order.
✦ Generated by Eureka AI based on patent content.
Abstract
The application discloses a quality control method for a swelling and pain relieving composition, which comprises the following steps: A, preparing a receiving side solution; B, using a YUS chamber to prepare a test sample solution, fixing rat skin in a 0.5 cm2 diffusion chamber, with the outer epidermis side as a drug administration side, adding a swelling and pain relieving extract to the drug administration side container, with the inner epidermis side as a receiving side, adding a receiving liquid to the receiving side container to two-thirds of the container, finally covering the top of the two containers with a fresh-keeping film, opening a constant temperature water bath to maintain a constant temperature of 37.5 DEG C, waiting for 36-48 hours, passing through a 0.22 mu m microporous filter membrane, taking the filtrate, and obtaining the test sample solution; C, using a liquid chromatography program to separate and then detecting by a UV detector. The method relies on a high performance liquid chromatograph, extracts transdermal components through a YUS chamber through an isolated rat skin, and forms a new type of quality control method for a swelling and pain relieving composition.
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