Process for the preparation of a biotin intermediate, cyclic anhydride
By using the dehydration reaction of cyclic metal salts with acetic anhydride under acidic conditions, the problems of high-temperature decomposition and excessive wastewater in the preparation of cyclic anhydride were solved, achieving the production of cyclic anhydride with high purity and high yield, simplifying the process and reducing energy consumption.
Patent Information
- Application Number
- CN202210776003.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-07-02
- Publication Date
- 2026-02-03
- Estimated Expiration
- 2042-07-02
AI Technical Summary
Existing methods for preparing cyclic anhydrides in biotin synthesis suffer from problems such as severe decomposition of raw materials at high temperatures, excessive wastewater and byproducts, and complex process control. In particular, the acetic acid and hydrochloric acid produced when using dehydrating reagents require sophisticated equipment and have high energy consumption during separation.
Using cyclic acid metal salts as raw materials, the cyclic acid metal salts are dehydrated with acetic anhydride in an aromatic hydrocarbon solvent under the catalysis of acidic substances. This eliminates the need for hydrochloric acid precipitation and allows for direct crystallization and separation of the cyclic acid metal salts, reducing high-temperature decomposition and side reactions. By separating byproducts by centrifugation, the process is simplified.
It improves the purity and yield of cyclic anhydride, reduces wastewater and energy consumption, simplifies the process, and lowers raw material consumption and production costs.