Two-dimensional metal-organic framework nanopore sensor and preparation method and application thereof
By using metal-organic framework films with porphyrin organic ligands in a two-dimensional nanopore sensor, the first nanopore was fabricated to slow down the DNA perforation rate, thus solving the problem of excessively fast DNA perforation and achieving high temporal resolution DNA detection.
CN117491429BActive Publication Date: 2026-06-30SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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Patent Information
- Application Number
- CN202210888588.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-07-26
- Publication Date
- 2026-06-30
- Estimated Expiration
- 2042-07-26
AI Technical Summary
Technical Problem
Existing two-dimensional nanopore sensors cannot meet the requirements for high-resolution identification of DNA bases in DNA detection due to the excessively fast DNA perforation speed.
Method used
A two-dimensional metal-organic framework nanopore sensor was used to fabricate the first nanopore by in-situ transferring a metal-organic framework thin film of porphyrin organic ligands that are self-assembled on a silicon nitride film, thereby slowing down the permeation rate of DNA.
Benefits of technology
While maintaining high spatial resolution, it significantly improves the temporal resolution of DNA detection, providing a new approach for highly sensitive and high-resolution two-dimensional nanopore sensors.
✦ Generated by Eureka AI based on patent content.
Abstract
The application discloses a two-dimensional metal organic framework nanopore sensor and a preparation method and application thereof. The two-dimensional metal organic framework nanopore sensor comprises a two-dimensional metal organic framework film with first nanopores, a silicon nitride film with second nanopores and a silicon substrate which are sequentially stacked, the two-dimensional metal organic framework film is formed through liquid-liquid interface force self-assembly and is transferred in situ to the silicon nitride film to form. The two-dimensional nanopore film material adopted by the application is a metal organic framework of a porphyrin organic ligand, the hydrophobic porphyrin ligand has high affinity with DNA molecules and can interact with the DNA molecules, so that the speed of the DNA passing through the two-dimensional nanopore is slowed down, the problem of fast pore passing speed when the two-dimensional nanopore sensor detects and distinguishes short-chain DNA is solved, and the time resolution capability of the two-dimensional nanopore is greatly improved under the premise of guaranteeing high spatial resolution of the two-dimensional nanopore.
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