A device and method for determining toxicity of antibiotics and intermediates in the process of treating the same in water

By setting a low-flow outlet and a fixed matrix in the plug flow reaction chamber, and utilizing antibiotic degradation of biological and photocatalytic materials, the problem of difficult determination of intermediate product toxicity was solved, and accurate determination of the toxicity of antibiotic parent material and intermediate products and simulation of natural pollution were achieved.

CN118667627BActive Publication Date: 2025-10-24SHANDONG UNIV
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Patent Information

Application Number
CN202410723174.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-06-05
Publication Date
2025-10-24
Estimated Expiration
2044-06-05

AI Technical Summary

Technical Problem

In existing toxicity assessment experiments, microorganisms can degrade antibiotics to produce intermediate products, resulting in a solution composition that differs from the original stock solution. This makes it difficult to determine the toxicity of the antibiotic itself at the set concentration, and the experiments cannot reflect the state of constant pollution in natural water bodies.

Method used

A plug flow reaction chamber is used, with multiple low-flow outlets. Antibiotics are degraded by antibiotic degradation organisms and/or photocatalytic materials on a fixed substrate. The toxicity of intermediate products at different degradation time points is reflected by the low-flow outlets, and the toxicity is determined in conjunction with biological toxicity testing.

Benefits of technology

It enables accurate determination of the toxicity of antibiotic parent compounds and intermediate products, simulates the continuous pollution state of water bodies in nature, provides a direct characterization method for experimental determination, and improves the accuracy of toxicity assessment.

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Abstract

The present application relates to a kind of water body antibiotic and its degradation intermediate toxicity determination device and method, belong to the detection technical field of water antibiotic.The determination device includes: degradation reaction chamber, degradation reaction chamber is horizontally arranged flat plug flow reactor, the two ends of flat plug flow reactor are continuous water inlet and continuous water outlet respectively;Degradation reaction chamber is provided with fixed matrix, and microbial membrane or photodegradation material is attached on fixed matrix, or continuous inlet section is connected with chemical oxidant;The bottom of degradation reaction chamber is provided with multiple low-flow water outlets at the distance set along length direction;Low-flow water outlet is connected with toxicity detection device;The flow ratio of single low-flow water outlet and continuous water outlet is 1:(300-1000), and the number of low-flow water outlet is 3-10.In flat plug flow reactor, the time difference of antibiotic degradation process can be reflected from different low-flow water outlet position, so toxicity is determined at each point, and the toxicity of antibiotic matrix and intermediate product can be more accurately obtained.
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