An apparatus and method for granulating a drug for sustained release

Abstract

This application relates to the field of pharmaceutical equipment technology, and discloses an apparatus and method for granulating sustained-release drugs, to solve the problem of rapid drug release from sustained-release tablets due to short compression time and lack of compaction. A granulation structure is fixedly installed inside a housing. The granulation structure includes a fixed plate, a support shaft, a rotating gear, and a granulation belt. The granulation belt has a granulation groove, and two granulation belts are installed in a V-shape. Powdered sustained-release drug is discharged into the granulation groove. A power motor drives the support shaft, rotating gear, and granulation belt to rotate in opposite directions, causing the granulation groove to compress the powdered sustained-release drug in the granulation groove. As the granulation groove moves from the top to the bottom of the granulation belt, the compressive force on the powdered sustained-release drug increases, and the compression time of the powdered sustained-release drug in the granulation groove is extended, so that the powdered sustained-release drug is compacted, preventing breakage of the compressed sustained-release tablets.

Description

Technical Field

[0001] This application relates to the field of pharmaceutical equipment technology, and more particularly to an apparatus and method for granulating sustained-release drugs. Background Technology

[0002] Sustained-release drugs, also known as sustained-release formulations, are preparations that, after oral administration, release the drug slowly and at a non-constant rate in a specified release medium. Sustained-release drugs include tablets, pills, capsules, injections, suppositories, and films. When using a drug granulation device to produce sustained-release tablets from powdered sustained-release drugs, two symmetrically arranged extrusion rollers rotate, causing the granulation grooves on the extrusion rollers to compress the powdered sustained-release drug, thus completing the production of sustained-release tablets.

[0003] During the granulation process of powdered sustained-release drugs, the sustained-release drugs are compressed by the rotation of the extrusion rollers. Only the contact point between the two extrusion rollers can compress the powdered sustained-release drugs. However, the contact time between the two extrusion rollers is short during compression; they separate after only a short compression period. The powdered sustained-release drugs fall into the chamber after only one short compression and are discharged immediately. This results in the sustained-release tablets not being compressed tightly. After a patient ingests a loosely compressed sustained-release tablet, it will quickly disperse in the body, thus failing to achieve the requirement of slow release of the sustained-release drug. Summary of the Invention

[0004] This application proposes an apparatus and method for granulating sustained-release drugs, which has the advantage of extending the compression time of sustained-release drugs, thereby solving the problem of rapid drug release from sustained-release tablets due to short compression time and lack of compaction.

[0005] To achieve the above objectives, this application adopts the following technical solution: an apparatus and method for granulating sustained-release drugs, comprising a housing, a granulation structure, a power motor, a material cylinder, a stirring structure, and a control system. The granulation structure includes: a fixed plate, fixedly connected to both sides of the inner wall of the housing; two sets of support rods, each set of support rods consisting of two equidistant support shafts, the two ends of which are movably inserted into the fixed plates on both sides; a rotating gear, fixedly sleeved in the middle position of the support shafts; and a granulation belt, movably sleeved on the outside of the same set of rotating gears, the two granulation belts being installed in a V-shape. The granulation belt has several granulation grooves evenly spaced for pressing powdered sustained-release drugs; a mounting shaft has both ends that are movably inserted into the fixing plates on both sides; a support gear is fixedly sleeved in the middle of the mounting shaft, with one side meshing with the inner wall of the granulation belt; a transmission belt is movably sleeved on the mounting shaft and the support shaft to drive the mounting shaft and the support shaft; a transmission gear is fixedly sleeved on one end of the topmost support shaft, and the two transmission gears mesh; one end of the topmost support shaft passes through and extends out of the side wall of the housing, and the output end of the power motor is fixedly connected to the end of the support shaft that passes through and extends out of the side wall of the housing.

[0006] Furthermore, the granulation structure includes: an annular gas ring embedded in the edge of the granulation tank, the annular gas ring being a hollow rubber ring; a one-way valve I embedded in the outer side of the annular gas ring and connected to the center of the annular gas ring; a pressure relief valve embedded in the inner side of the annular gas ring; a vent hole opened in the granulation belt and used to connect the pressure relief valve and the middle position of the granulation tank; and a rubber disc disposed in the granulation tank, with its edge sealed to the edge of the granulation tank.

[0007] Furthermore, an exhaust hole is provided on one side of the granulation belt, which is connected to the ventilation hole at the middle position. The exhaust hole is equipped with: a support spring, one end of which is fixedly connected to the bottom end of the exhaust hole; a plug, which is fixedly connected to the other end of the support spring and is slidably sealed in the exhaust hole to block the connection between the exhaust hole and the ventilation hole; a one-way valve II, which is fixedly installed at the end of the exhaust hole; and permanent magnet strips, which are fixedly installed on both sides of the inner wall of the fixing plate facing the exhaust hole of the granulation belt.

[0008] Furthermore, the flow direction of the one-way valve I is from the outside to the inside of the annular gas ring; the flow direction of the pressure relief valve is from the inside of the annular gas ring to the vent hole; and the flow direction of the one-way valve II is from the exhaust hole to the outside.

[0009] Furthermore, the support spring is always in a compressed state.

[0010] Furthermore, the blocking block is a permanent magnet, and the blocking block generates a magnetic force that repels the permanent magnet strip.

[0011] Furthermore, a permanent magnet is embedded in the center of the rubber disc, and several equidistant electromagnetic strips are fixedly installed on the side walls on both sides of the fixing plate. The electromagnetic strips are electrically connected to the control system. When the electromagnetic strips are energized, the magnetic poles of the electromagnetic strips facing the granulation belt are intermittently arranged as S poles and N poles.

[0012] Furthermore, a method of using a device for preparing a drug sustained-release system includes the following steps:

[0013] S1, dihydroergot methanesulfonate raw materials and excipients are added into the feed cylinder and mixed evenly by the stirring structure;

[0014] S2. The mixed powdered sustained-release drug is discharged into the granulation tank of the granulation structure through the discharge pipe of the material cylinder. The rotating granulation belts on both sides press the powdered sustained-release drug in the granulation tank. The gap between the two granulation belts gradually decreases, increasing the pressing force on the powdered sustained-release drug, thereby obtaining the sustained-release product of dihydroergot mesylate.

[0015] S3. During the pressing process, the annular gas ring is compressed. The gas in the annular gas ring enters the granulation tank and the bottom of the rubber disc through the pressure relief valve and the vent. The gas compresses the rubber disc, increasing the compressive force on the powdered sustained-release drug in the rubber disc.

[0016] S4. When the granulation tank is rotated to the lower end, the slow-release tablets in the granulation tank and the rubber disc are no longer subjected to the squeezing force on both sides. The gas expansion between the granulation tank and the rubber disc pushes the rubber disc to bulge, which helps the slow-release tablets in the rubber disc to fall off.

[0017] S5. From the bottom up position of the granulation belt, the block in the exhaust hole is pushed by the permanent magnet strip, opening the connection between the vent hole and the exhaust hole, so that the gas in the vent hole can be discharged through the exhaust hole and the one-way valve II.

[0018] S6. From bottom to top, the electromagnetic strip alternately attracts or repels the permanent magnet block, causing the permanent magnet block to drive the rubber disc to shake in the granulation tank, thereby shaking off the residual powder in the rubber disc. Furthermore, when the permanent magnet block is subjected to repulsive force, it squeezes the gas between the granulation tank and the rubber disc, causing the rubber disc to push the gas at the bottom of the rubber disc to be discharged.

[0019] This application has the following beneficial effects:

[0020] 1. This application provides an apparatus and method for granulating sustained-release drugs. A granulation structure is fixedly installed inside a housing. The granulation structure includes a fixed plate, support shafts, rotating gears, and granulation belts. Granulation grooves are evenly spaced on the granulation belts. Two granulation belts are installed in a V-shape, with a larger distance between them near the discharge port of the feed cylinder. Powdered sustained-release drugs are discharged from the discharge port of the feed cylinder into the granulation grooves. A power motor drives the two support shafts, rotating gears, and granulation belts to rotate in opposite directions, thereby pressing the powdered sustained-release drugs in the granulation grooves on both sides. As the powdered sustained-release drugs move from the top to the bottom of the granulation belts, the distance between the two granulation belts gradually decreases, thereby increasing the pressing force on the powdered sustained-release drugs and prolonging the pressing time of the granulation grooves on the powdered sustained-release drugs. This ensures that the powdered sustained-release drugs are compacted, preventing the phenomenon of rapid drug release after administration of the compressed sustained-release tablets.

[0021] 2. This application provides an apparatus and method for granulating sustained-release drugs. An annular gas ring is provided at the edge of the granulation tank. The annular gas ring is equipped with a one-way valve I connected to a transmission gear and a pressure relief valve. A vent hole is provided on the granulation belt, connecting the pressure relief valve and the bottom end of the granulation belt. A rubber disc is sealed inside the granulation tank. During the pressing of the powdered sustained-release drug, the annular gas rings on opposite surfaces of the granulation belt are mutually compressed. The gas inside the annular gas rings enters the granulation tank at the bottom end of the rubber disc through the pressure relief valve and the vent hole, thereby increasing the pressing force on the powdered sustained-release drug. Simultaneously, when the granulation tank moves to its lowest point, the gas between the rubber disc and the granulation tank expands, causing the rubber disc to bulge and deform, thus detaching the sustained-release tablets from the rubber disc and preventing the pressed sustained-release tablets from sticking to the rubber disc and affecting the entry of subsequent raw materials.

[0022] 3. This application provides an apparatus and method for granulating sustained-release drugs. An exhaust port with a connecting vent is provided on the granulation belt. The exhaust port contains a support spring, a plug, and a one-way valve II. A permanent magnet strip is provided on the surface of a fixed plate facing the one-way valve II. A permanent magnet block is embedded in the center of a rubber disc. Several electromagnetic strips are equidistantly arranged on both sides of the fixed plate. When the electromagnetic strips are energized, their N and S poles are intermittently aligned towards the inside. After the sustained-release tablets are discharged, the plug in the exhaust port faces the permanent magnet strip. The permanent magnet strip generates a magnetic force that repels the plug, preventing it from blocking the connection between the vent and the exhaust port. Simultaneously, the permanent magnet block in the rubber disc is subjected to the intermittent attraction and repulsion of the electromagnetic strips, causing the permanent magnet block to drive the rubber disc to shake, dislodging any residual powder in the rubber disc. This prevents the subsequent processing of powdered sustained-release drugs in the rubber disc from affecting the weight of the sustained-release tablets. Furthermore, the shaking of the rubber disc pushes the gas at the bottom of the rubber disc out, preventing the presence of gas at the bottom of the rubber disc from affecting the amount of powdered sustained-release drugs entering the rubber disc. Attached Figure Description

[0023] The accompanying drawings, which form part of this specification, illustrate embodiments disclosed in this application and, together with the specification, serve to explain the principles disclosed in this application.

[0024] This disclosure will become clearer with reference to the accompanying drawings and the following detailed description, wherein:

[0025] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0026] Figure 2 This is a schematic diagram of the box body and granulation structure of the present invention;

[0027] Figure 3 This is a schematic diagram of the granulation structure of the present invention;

[0028] Figure 4 This is a cross-sectional view of the granulation belt of the present invention;

[0029] Figure 5 For the present invention Figure 4 Enlarged view of the local structure at point A;

[0030] Figure 6 This is a cross-sectional view of the granulation belt of the present invention from the axis of the one-way valve II;

[0031] Figure 7 For the present invention Figure 6 Enlarged view of the local structure at point B;

[0032] Figure 8 This is a schematic diagram of the internal structure of the granulation structure of the present invention.

[0033] In the diagram: 1. Box body; 2. Granulation structure; 201. Fixing plate; 202. Support shaft; 203. Rotating gear; 204. Granulation belt; 205. Granulation trough; 206. Transmission gear; 207. Annular air ring; 208. One-way valve I; 209. Pressure relief valve; 210. Vent hole; 211. Rubber disc; 212. Support spring; 213. Block; 214. One-way valve II; 215. Permanent magnet strip; 216. Permanent magnet block; 217. Electromagnetic strip; 218. Mounting shaft; 219. Support gear; 220. Transmission belt; 3. Power motor; 4. Material cylinder; 5. Stirring structure. Detailed Implementation

[0034] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0035] Example 1

[0036] Please see Figure 1 An apparatus for granulating sustained-release drugs includes a housing 1, a granulation structure 2, a power motor 3, a material cylinder 4, a stirring structure 5, and a control system. The granulation structure 2 is fixedly installed inside the housing 1. The power motor 3 is fixedly installed on one side of the housing 1. The power motor 3 is used to drive the granulation structure 2 to press the powdered sustained-release drug. The material cylinder 4 is fixedly installed at the top of the housing 1. The material cylinder 4 is used to hold the powdered sustained-release drug. The discharge pipe of the material cylinder 4 is directly opposite the middle position of the granulation structure 2. The control system controls the discharge of the powdered sustained-release drug in the material cylinder 4. The stirring structure 5 is fixedly installed inside the material cylinder 4 to stir the powdered sustained-release drug.

[0037] Please see Figures 1-4 The granulation structure 2 includes a fixed plate 201, a support shaft 202, a rotating gear 203, a granulation belt 204, a transmission gear 206, a mounting shaft 218, a support gear 219, and a transmission belt 220. The fixed plate 201 is fixedly connected to both sides of the inner wall of the housing 1. Two sets of support rods are movably inserted into the fixed plates 201 on both sides. Each set of support rods consists of two support shafts 202. A rotating gear 203 is fixedly sleeved in the middle of the support shaft 202. A granulation belt 204 is movably sleeved on the outer side of the same set of rotating gears 203. A mounting shaft 218 is movably inserted into the fixed plate 201 between the two support shafts 202. A support gear 219 is fixedly sleeved in the middle of the mounting shaft 218. One side of the support gear 219 meshes with the inner wall of one side of the two closely spaced granulation belts 204. The support gear 219 supports the granulation belt 204. The mounting shaft 218 and the support shaft 202 are driven by the transmission belt 220. The diameter of the mounting shaft 218 is the same as the diameter of the support shaft 202. The ratio is equal to the ratio of the number of teeth of the support gear 219 to the number of teeth of the rotating gear 203. Since the mounting shaft 218 and the support shaft 202 have different diameters, when the transmission belt 220 drives the belt, the linear velocity of the rotating gear 203 on the support shaft 202 is the same as the linear velocity of the support gear 219 on the mounting shaft 218. This ensures that the granulation belt 204 can accurately mesh with the rotating gear 203 and the support gear 219. The two granulation belts 204 are installed in a V-shape, and the discharge pipe of the material cylinder 4 is positioned between the two granulation belts. At the maximum spacing of the granulation belt 204, several granulation grooves 205 for pressing powdered sustained-release drugs are equally spaced on the granulation belt 204. A transmission gear 206 is fixedly sleeved on one end of the topmost support shaft 202. Two transmission gears 206 mesh. One end of the topmost support shaft 202 passes through and extends out of the side wall of the box 1. A power motor 3 is fixedly installed on the side wall of the box 1, and the output end of the power motor 3 is fixedly connected to the end of the support shaft 202 that passes through and extends out of the side wall of the box 1.

[0038] The working principle of Embodiment 1 of the present invention is as follows:

[0039] Please see Figures 1-4 In the process of preparing sustained-release tablets from powdered sustained-release drugs, the powdered sustained-release drugs are placed in a cylinder 4. A stirring structure 5 mixes the powdered sustained-release drugs in the cylinder 4 evenly and controls the discharge of the powdered sustained-release drugs from the discharge pipe of the cylinder 4. Simultaneously, a power motor 3 drives a support shaft 202 to rotate, which in turn drives a rotating gear 203 and a granulation belt 204 to rotate. Through the transmission gear 206, the two granulation belts 204 rotate relative to each other. During this process, the powdered sustained-release drugs fall into the two granulation troughs 205 at the top and close to each other on the granulation belts 204. 04 During the continued rotation, the powdered sustained-release drug in the two granulation tanks 205 is repeatedly squeezed by the two granulation belts 204, thereby compressing the powdered sustained-release drug into sustained-release tablets. Furthermore, as the granulation tanks 205 move from the top to the bottom, the distance between the two granulation belts 204 gradually decreases, and the pressing force of the granulation belts 204 on the powdered sustained-release drug in the granulation tanks 205 gradually increases, prolonging the pressing time of the powdered sustained-release drug in the granulation tanks 205. This ensures that the powdered sustained-release drug is compressed tightly, preventing the phenomenon of rapid drug release after administration of the compressed sustained-release tablets.

[0040] Example 2

[0041] Example 2 is a further improvement based on Example 1.

[0042] Unlike Example 1, please refer to Figure 4 and Figure 5 The granulation tank 205 has an annular gas ring 207 embedded on its edge. The annular gas ring 207 is a hollow rubber ring that can automatically recover its shape after being compressed and deformed. A one-way valve I 208 connected to the center of the annular gas ring 207 is embedded on the outer side of the annular gas ring 207. A pressure relief valve 209 connected to the center of the annular gas ring 207 is embedded on the inner side of the annular gas ring 207. Several vent holes 210 are opened in the granulation belt 204. The vent holes 210 are used to connect the pressure relief valve 209 and the middle position of the granulation tank 205. A rubber disc 211 is provided in the granulation tank 205. The shape of the rubber disc 211 is the same as that of the granulation tank 205, and the edge of the rubber disc 211 is sealed to the edge of the granulation tank 205. The bottom end of the rubber disc 211 can be bulged after being inflated. After the gas at the bottom end of the rubber disc 211 is discharged, it can automatically return to its original shape.

[0043] Please see Figure 6 and Figure 7A vent hole is provided on one side of the granulation belt 204, connecting to the vent hole 210. The vent hole and the vent hole 210 are connected at the middle position. A support spring 212 is fixedly connected to the bottom end of the vent hole, and a block 213 is fixedly connected to the other end of the support spring 212. The block 213 is slidably sealed inside the vent hole, blocking the connection between the vent hole and the vent hole 210 to prevent gas in the vent hole 210 from escaping from the vent hole. A limit ring is fixedly installed on the inner wall of the vent hole to limit the block 213 and prevent it from being pushed out by the support spring 212. A one-way valve II 214 is fixedly installed at the end of the vent hole. Please refer to [link / reference]. Figure 8 Permanent magnet strips 215 are fixedly installed on both sides of the inner wall of the fixing plate 201 facing the exhaust holes of the granulation belt 204, and the permanent magnet strips 215 are opposite to the exhaust holes on both sides of the granulation belt 204.

[0044] The flow direction of one-way valve I 208 is from the outside to the inside of the annular gas ring 207; the flow direction of pressure relief valve 209 is from the inside of the annular gas ring 207 to the vent 210; the flow direction of one-way valve II 214 is from the exhaust port to the outside.

[0045] The support spring 212 is always in a compressed state. The compressed support spring 212 provides support for the block 213, preventing the block 213 from blocking the vent 210 and hindering the flow of gas.

[0046] The blocking block 213 is a permanent magnet, which generates a magnetic force that repels the permanent magnet strip 215. When the blocking block 213 is facing the permanent magnet strip 215, the blocking block 213 is pushed by the magnetic force generated by the permanent magnet strip 215, and the blocking block 213 compresses the support spring 212. The blocking block 213 no longer blocks the connection between the vent hole 210 and the exhaust hole, allowing the gas in the vent hole 210 to enter the exhaust hole and then flow out through the one-way valve II 214.

[0047] The working principle of Embodiment 2 of the present invention is as follows:

[0048] Please see Figures 1-8During the compression of the powdered sustained-release drug by the granulation grooves 205 on the granulation belts 204 on both sides, as the distance between the two granulation belts 204 gradually decreases, the annular air ring 207 at the edge of the granulation groove 205 is also gradually compressed. This causes the gas inside the annular air ring 207 to be discharged through the pressure relief valve 209 into the vent hole 210. The gas then enters the space between the granulation groove 205 and the rubber disc 211 through the vent hole 210, thereby increasing the squeezing force of the rubber disc 211 on the powdered sustained-release drug, increasing the compression effect, and making the compressed sustained-release tablets more compact. Simultaneously, When the granulation tank 205 moves to the bottom, the granulation tanks 205 on both sides are staggered. The compressed sustained-release tablets are no longer supported by the rubber discs 211 on both sides and the granulation tank 205. The gas between the rubber discs 211 and the granulation tank 205 expands, causing the rubber discs 211 to bulge. The bulging rubber discs 211 lift the sustained-release tablets in the rubber discs 211, thereby helping the sustained-release tablets in the rubber discs 211 to fall off and preventing the sustained-release tablets in the rubber discs 211 from sticking to the rubber discs 211 and hindering the subsequent entry of powdered sustained-release drugs into the rubber discs 211.

[0049] Furthermore, on the side where the granulation belt 204 moves from bottom to top, the block 213 in the exhaust hole generates a magnetic force that repels the permanent magnet strip 215. The block 213 is pushed by the permanent magnet strip 215, causing the block 213 to squeeze the support spring 212. The block 213 no longer blocks the connection between the vent hole 210 and the exhaust hole, allowing the gas in the vent hole 210 to enter the exhaust hole and then flow out through the one-way valve II 214.

[0050] Example 3

[0051] Example 3 is a further improvement based on Example 2.

[0052] Unlike Example 2, please refer to Figure 7 A permanent magnet 216 is embedded in the center of the rubber disc 211. Please refer to [link / reference]. Figure 8 Several electromagnetic strips 217 are fixedly installed on the side walls of both sides of the fixed plate 201. The electromagnetic strips 217 are electrically connected to the control system. When the electromagnetic strips 217 are energized, the magnetic poles of the electromagnetic strips 217 facing the granulation belt 204 are intermittently arranged as S poles and N poles.

[0053] The working principle of Embodiment 3 of the present invention is as follows:

[0054] Please see Figures 1-8When the machine is running, the control system energizes the electromagnetic strip 217. On the side of the granulation belt 204 that moves from bottom to top, the permanent magnet 216 on the rubber disc 211 in the granulation tank 205 faces the electromagnetic strip 217 on the side wall of the fixed plate 201. Because the electromagnetic strip 217 is energized, it generates magnetic force. This magnetic force alternately attracts or repels the permanent magnet 216, causing the permanent magnet 216 to drive the rubber disc 211 to vibrate within the granulation tank 205, thereby removing residual powder from the rubber disc 211. The powdered sustained-release drug is not shaken off to prevent it from affecting the weight of the sustained-release tablets after entering the rubber disc 211. Furthermore, when the permanent magnet 216 is subjected to repulsive force, it drives the rubber disc 211 to move towards the bottom of the granulation tank 205. This causes the rubber disc 211 to squeeze the gas between the granulation tank 205 and the rubber disc 211, and pushes the gas at the bottom of the rubber disc 211 to be discharged. This prevents the presence of gas at the bottom of the rubber disc 211 from affecting the amount of powdered sustained-release drug that enters the rubber disc 211 afterward.

[0055] The method of using the apparatus for granulation of sustained-release drugs when preparing dihydroergot methyl methacrylate sustained-release products includes the following steps:

[0056] S1, dihydroergot methanesulfonate raw material and excipients are added to the feed cylinder 4, and the raw materials are mixed evenly by the stirring structure 5;

[0057] S2. The mixed powdered sustained-release drug is discharged into the granulation tank 205 of the granulation structure 2 through the discharge pipe of the material cylinder 4. The rotating granulation belts 204 on both sides press the powdered sustained-release drug in the granulation tank 205. The distance between the two granulation belts 204 gradually decreases, increasing the pressing force on the powdered sustained-release drug, thereby obtaining the sustained-release product of dihydroergot mesylate.

[0058] S3. During the pressing process, the annular gas ring 207 is compressed. The gas in the annular gas ring 207 enters the granulation tank 205 and the bottom of the rubber disc 211 through the pressure relief valve 209 and the vent 210. The gas compresses the rubber disc 211, increasing the compressive force on the powdered sustained-release drug in the rubber disc 211.

[0059] S4. When the granulation tank 205 rotates to the lower end, the sustained-release tablets in the granulation tank 205 and the rubber disc 211 are no longer subjected to the squeezing force on both sides. The gas expansion between the granulation tank 205 and the rubber disc 211 pushes the rubber disc 211 to bulge, which helps the sustained-release tablets in the rubber disc 211 to fall off.

[0060] S5. From bottom to top, the block 213 in the vent hole of the granulation belt 204 is pushed by the permanent magnet strip 215, opening the connection between the vent hole 210 and the vent hole, so that the gas in the vent hole 210 can be discharged through the vent hole and the one-way valve II 214.

[0061] S6. From bottom to top, the electromagnetic strip 217 alternately attracts or repels the permanent magnet block 216, causing the permanent magnet block 216 to drive the rubber disc 211 to shake in the granulation tank 205, thereby shaking off the powder remaining in the rubber disc 211. Furthermore, when the permanent magnet block 216 is subjected to repulsive force, it squeezes the gas between the granulation tank 205 and the rubber disc 211, causing the rubber disc 211 to push the gas at the bottom of the rubber disc 211 out.

Claims

1. An apparatus for granulating sustained-release drugs, comprising a housing (1), a granulation structure (2), a power motor (3), a feed cylinder (4), a stirring structure (5), and a control system, characterized in that: The granulation structure (2) includes: Fixed plate (201) is fixedly connected to both sides of the inner wall of the box (1); Two sets of support rods, each set of support rods consists of two equally spaced support shafts (202), the two ends of which are movably inserted into the fixing plates (201) on both sides; A rotating gear (203) is fixedly sleeved at the middle position of the support shaft (202); The granulation belt (204) is movably sleeved on the outside of the same set of rotating gears (203). The two granulation belts (204) are installed in a V-shape. The granulation belt (204) is provided with a plurality of granulation grooves (205) for pressing powdered sustained-release drugs at equal intervals. The mounting shaft (218) is movably inserted into the fixing plates (201) on both sides at both ends; The support gear (219) is fixedly sleeved in the middle position of the mounting shaft (218), and one side meshes with the inner wall of the granulation belt (204); The transmission belt (220) is movably sleeved on the mounting shaft (218) and the support shaft (202) to drive the mounting shaft (218) and the support shaft (202); The transmission gear (206) is fixedly sleeved on one end of the topmost support shaft (202), and the two transmission gears (206) mesh. One end of the topmost support shaft (202) extends through and out of the side wall of the housing (1), and the output end of the power motor (3) is fixedly connected to the end of the support shaft (202) that extends through and out of the side wall of the housing (1).

2. The apparatus for sustained-release drug granulation according to claim 1, characterized in that: The granulation structure (2) is provided with: An annular gas ring (207) is embedded in the edge of the granulation tank (205), and the annular gas ring (207) is a hollow rubber ring; One-way valve I (208) is embedded on the outside of the annular gas ring (207) and is connected to the center of the annular gas ring (207); Pressure relief valve (209) is embedded inside the annular gas ring (207); A vent (210) is provided inside the granulation belt (204) and is used to connect the pressure relief valve (209) and the granulation tank (205) at the middle position; A rubber disc (211) is installed inside the granulation tank (205), with its edge sealed to the edge of the granulation tank (205).

3. The apparatus for sustained-release drug granulation according to claim 2, characterized in that: The granulation belt (204) has an exhaust hole on one side that connects to the ventilation hole (210). The exhaust hole is connected to the ventilation hole (210) at the middle position. The exhaust hole is provided with: A support spring (212) is fixedly connected at one end to the bottom of the vent hole; The plug (213) is fixedly connected to the other end of the support spring (212) and is slidably sealed inside the vent hole, used to block the connection between the vent hole and the air hole (210); One-way valve II (214) is fixedly installed at the end of the exhaust port; The permanent magnet strip (215) is fixedly installed on both sides of the inner wall of the fixing plate (201) facing the exhaust hole of the granulation belt (204).

4. The apparatus for sustained-release drug granulation according to claim 3, characterized in that: The flow direction of the one-way valve I (208) is from the outside to the inside of the annular gas ring (207); the flow direction of the pressure relief valve (209) is from the inside of the annular gas ring (207) to the vent (210); the flow direction of the one-way valve II (214) is from the exhaust hole to the outside.

5. The apparatus for sustained-release drug granulation according to claim 3, characterized in that: The support spring (212) is always in a compressed state.

6. The apparatus for sustained-release drug granulation according to claim 3, characterized in that: The block (213) is a permanent magnet, and the block (213) generates a magnetic force that repels the permanent magnet strip (215).

7. The apparatus for sustained-release drug granulation according to claim 3, characterized in that: A permanent magnet block (216) is embedded in the center of the rubber disc (211). Several electromagnetic strips (217) are fixedly installed on the side walls of both sides of the fixing plate (201). The electromagnetic strips (217) are electrically connected to the control system. When the electromagnetic strips (217) are energized, the magnetic poles of the electromagnetic strips (217) facing the granulation belt (204) are intermittently arranged as S poles and N poles.

8. The method of using the apparatus for sustained-release drug granulation according to claim 7, characterized in that, Includes the following steps: S1, dihydroergot methanesulfonate raw materials and excipients are added to the feed cylinder (4), and the raw materials are mixed evenly by the stirring structure (5); S2. The mixed powdered sustained-release drug is discharged into the granulation tank (205) of the granulation structure (2) through the discharge pipe of the material cylinder (4). The rotating granulation belts (204) on both sides press the powdered sustained-release drug in the granulation tank (205). The distance between the granulation belts (204) on both sides gradually decreases, increasing the pressing force on the powdered sustained-release drug, thereby obtaining the sustained-release product of dihydroergot mesylate. S3. During the pressing process, the annular gas ring (207) is squeezed. The gas in the annular gas ring (207) enters the granulation tank (205) and the bottom of the rubber disc (211) through the pressure relief valve (209) and the vent (210). The gas squeezes the rubber disc (211) and increases the squeezing force on the powdered sustained-release drug in the rubber disc (211). S4. When the granulation tank (205) is rotated to the lower end, the sustained-release tablets in the granulation tank (205) and the rubber disc (211) are no longer subjected to the squeezing force on both sides. The gas expansion between the granulation tank (205) and the rubber disc (211) pushes the rubber disc (211) to bulge, which helps the sustained-release tablets in the rubber disc (211) to fall off. S5. From bottom to top, the block (213) in the vent hole of the granulation belt (204) is pushed by the permanent magnet strip (215) to open the connection between the vent hole (210) and the vent hole, so that the gas in the vent hole (210) can be discharged through the vent hole and the one-way valve II (214). S6. From bottom to top, the electromagnetic strip (217) alternately attracts or repels the permanent magnet block (216) on the granulation belt (204), causing the permanent magnet block (216) to drive the rubber disc (211) to shake in the granulation tank (205), thereby shaking off the powder remaining in the rubber disc (211). When the permanent magnet block (216) is subjected to repulsive force, it squeezes the gas between the granulation tank (205) and the rubber disc (211), causing the rubber disc (211) to push the gas at the bottom of the rubber disc (211) to be discharged.

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