Traditional Chinese medicine prescription for clearing away heat and toxic materials and treating and reducing deeply burnt skin and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine application formula for clearing away heat and toxic materials and treating and restoring deeply burnt skin and a preparation method. The invention is derived from the traditional Chinese medicine family, is a secret prescription researched under the condition of lack of doctors and few medicines in Qiangxi of the Chongcheng era, and is externally applied and orally taken to treat burns and scalds and modern electric shock chemical medicine burns. According to the invention, honey-refined licorice and fermented red sage root are used; the traditional Chinese medicine composition is prepared from radix polygoni multiflori, airpotato yam rhizome, euphorbia humifusa, dysosma versipellis, artemisia rupestris, paris polyphylla, toad pseudo-ginseng, mahonia fortunei, fructus rosae laevigatae, smoked plum, realgar lotus, radix berberidis, saruma henryi, blood centipede, verbena, sesame stalk, shortleaf kyllinga herb, root of pilose asiabell, rhizoma bletillae, phoenix-tail fern, oldenlandia diffusa, cactus, rhizoma acori graminei, acronychia lanceolata, hemsleya amabilis, radix angelicae, soirodela polyrrhiza, radix stemonae, rubus idaeus, honeysuckle The traditional Chinese medicine application formula prepared from the eleocharis yokoscensis, the lysimachia capillipes hemsl, the sesame oil and the tung oil has a great prospect in the fields of clearing away heat and toxic materials and treating and restoring deep burn skin by combining an ancestral secret formula with a modern scientific and convenient mode.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicines, and in particular to medicines for burns and scalds; in particular to a traditional Chinese medicine compress prescription for clearing away heat and detoxifying, and treating and restoring deeply burned skin, and a preparation method thereof. Background Art

[0002] Chinese medicine preparations are mainly divided into Chinese medicine mixtures, prescriptions and single prescriptions. Among them, Chinese medicine mixtures have the effects of anti-shock, infection control, wound healing, scar hyperplasia and itching, and are widely used in burn treatment; prescriptions have many dosage forms, and are mainly used to protect wounds and promote wound repair in clinical practice; single prescriptions have a relatively simple composition, so there are many types, most of which are circulated among the people, with the advantages of convenient material collection and simple usage, and are mainly used in the treatment of degree I and II burn wounds. In the Han Dynasty, "Wuwei Han Dynasty Medical Bamboo Slips" collectively referred to burns as "tanghuodong". In the long clinical practice, Chinese medicine has achieved good preventive and therapeutic effects in the treatment of various diseases. Because of its special effects, its application range has been continuously expanded. Chinese medicine preparations have gradually attracted the attention of patients and medical staff due to their economic benefits, few adverse reactions, and green medical concepts. However, the current effect of Chinese medicine treatment is not significant, recovery takes a long time, and the treatment is limited. Therefore, the present invention proposes a pure Chinese medicine external application prescription for treating deep burns and scalds, deep to muscles or tendons and bones, severe water scalds with skin collapse and flesh rot, fire burns, and treating furuncle suppurative infection and snake bite suppurative infection. The medicinal application prescription has significant efficacy, clears away heat, detoxifies, relieves pain, has strong detoxification, astringes, and promotes tissue regeneration, and has the great advantages of no pruritus marks and restoring the original skin. Summary of the invention

[0003] In view of the above problems, the present invention provides a traditional Chinese medicine compress prescription for clearing away heat and detoxifying, treating and restoring deep burnt skin, and a preparation method thereof.

[0004] In a first aspect, the present invention provides a Chinese medicine compress for clearing away heat and detoxifying, treating and restoring deep burn skin, comprising, by weight: 5.5 parts of snake but, 4.5 parts of Dioscorea bulbifera, 5.5 parts of Dioscorea chinensis, 7.5 parts of Illustris octagonalis, 5.5 parts of Artemisia selengensis, 4.5 parts of Polygonum multiflorum, 4.5 parts of Radix Notoginseng, 7.5 parts of Mahonia, 7.5 parts of Rosa rugosa, 4.5 parts of Plum Grass, 4.5 parts of Realgar Lotus, 5.5 parts of Three Needles, 7.5 parts of Horse Hoof Fragrant, 5.5 parts of Blood Scolopendra, 4.5 parts of Verbena, 7.5 parts of Sesame Stalks, 3.5 parts of Water Scolopendra, 4.5 parts of Iron Horse Root, 5.5 parts of Bletilla striata, 4.5 parts of phoenix tail grass, 4.5 parts of oldenlandia diffusa, 4.5 parts of cactus, 7.5 parts of calamus, 7.5 parts of needle hair, 5.5 parts of snake, 4.5 parts of angelica dahurica, 7.5 parts of duckweed, 4.5 parts of stemona, 4.5 parts of small grass, 4.5 parts of honeysuckle, 7.5 parts of nine-returning-yang, 7.5 parts of cow-hair felt, 7.5 parts of stone lotus, 2.5 parts of liquorice, 4.5 parts of salvia miltiorrhiza, 15-20 parts of sesame oil, and 15-20 parts of tung oil; wherein the liquorice is refined with honey and then subjected to water extraction treatment; the salvia miltiorrhiza is soaked in 75% ethanol, dried and crushed, and then fermented and extracted by using a composite strain.

[0005] Preferably, the composite strain comprises Lactobacillus plantarum ATCC 8014 and Bacillus subtilis ATCC 6633.

[0006] In a second aspect, the present invention provides a method for preparing a Chinese medicine compress for clearing away heat and detoxifying, treating and restoring deep burn skin, and the specific preparation method is as follows:

[0007] S1. Take snake but not more than 5.5g, yellow medicine 4.5g, ground brocade 5.5g, eight angle lotus 7.5g, one wormwood 5.5g, seven leaf aconite 4.5g, toad Panax notoginseng 4.5g, ten great magnolia 7.5g, golden cherry 7.5g, sour plum grass 4.5g, realgar lotus 4.5g, three needles 5.5g, horse hoof incense 7.5g, blood centipede 5.5g, verbena 4.5g, sesame stalk 7.5g, water centipede 3.5g, iron horse root 4.5g, white 5.5g, phoenix tail grass 4.5g, white flower 4.5g of Hedyotis diffusa, 4.5g of Opuntia cochinchinensis, 7.5g of Acorus calamus, 7.5g of Rhizoma Atractylodis Macrocephalae, 5.5g of Herba Epimedii, 4.5g of Angelica dahurica, 7.5g of Duckweed, 4.5g of Radix Stemonae, 4.5g of Herba Artemisiae Argyi, 4.5g of Caulis Loniceraes, 7.5g of Rhizoma Cibotii, 7.5g of Rhizoma Cibotii, 7.5g of Echeveria, 2.5g of Radix Glycyrrhizae, and 4.5g of Radix Salviae Miltiorrhizae were soaked in water for 1-1.5h respectively, and all the soaked herbs were washed and dried, and then sterilized under high pressure at 0.1Mpa and 121℃ for 15min;

[0008] S2, prepared at a concentration of 1.21×10 8 ~1.25×10 8cfu / ml of Lactobacillus plantarum ATCC 8014 bacterial solution, take 10-12 ml into a bacterial solution container for later use; prepare a concentration of 3.19×10 9 ~3.25×10 9 cfu / ml of Bacillus subtilis ATCC6633 bacterial solution, take 12-15 ml and put it into the bacterial solution tank containing Lactobacillus plantarum, so that the two bacterial solutions are mixed in the bacterial solution tank, and then standby after mixing;

[0009] S3, take the licorice treated in step S1, moisten it with pure water, cut it into thick slices, dry it, and obtain clean licorice slices, then dilute 4-8g of refined honey in a casserole filled with 30-35ml of boiling water, add the clean licorice slices after dilution, mix well, simmer thoroughly, and then fry it with a slow fire until it turns yellow and does not stick to the hands, take it out, and let it cool to obtain honey-refined licorice;

[0010] S4, add 150 mL of water to the honey-refined licorice obtained in step S3, soak for 28 to 32 minutes, place on an electromagnetic cooker and heat at a power of 2100 W, after boiling, change the power to 600 W, decoct for 18 to 20 minutes, filter out, add 150 to 200 mL of water during the second decoction, decoct for 11 to 15 minutes after boiling, cool after decoction, combine the two filtrates, concentrate the filtrate and make up to 25 mL to obtain a licorice extract;

[0011] S5, drying and crushing the processed Salvia miltiorrhiza in step S1, passing the crushed Salvia miltiorrhiza through a 50-mesh sieve, sterilizing it under high pressure and putting it into the bacterial liquid cylinder prepared in step S2, culturing it in a 28°C incubator for 25-30h, sterilizing and cooling it to room temperature to obtain a fermented Salvia miltiorrhiza, adding 6-8 times the amount of water to the fermented Salvia miltiorrhiza, decocting it for 1h, repeating it twice, combining the filtrate, concentrating the filtrate and fixing it to 20mL, obtaining a concentrated solution after the fermentation of Salvia miltiorrhiza, and setting it aside;

[0012] S6, except for the medicinal materials obtained in step S1, such as licorice, salvia miltiorrhiza, seven-leaf gentian, realgar lotus, horse hoof fragrance, sesame stem, snake, white striata, cactus, angelica dahurica, purple duckweed, nine-returning yang, cow hair felt, and stone lotus, use a stone mortar to crush each medicine separately until it is loose and powder is not seen, add 15-20g sesame oil, boil and float three times, cool to 20-25℃, use an open container to soak the crushed loose medicine after boiling in sesame oil, and put the medicine The medicinal liquid is fully fermented for 15 to 17 days in winter and spring, or 7 to 9 days in summer and autumn, and then 30% of the medicinal liquid is extracted by stone milling to obtain sesame oil-processed medicinal liquid. The residue of the whole medicinal material with 70% of the medicinal ingredients remaining is added with 15 to 20g of tung oil to boil the medicinal material into yellow-black color, and the extracted medicinal liquid is filtered with a sieve and cooled to 15 to 18°C ​​for use, the residue is filtered out, and the remaining liquid is taken out to obtain the tung oil-boiled medicinal liquid;

[0013] S7, using a stone mortar to pound the 11 herbs washed in step S1, including seven-leaf parsley, realgar lotus, horse hoof fragrant, snakehead, white striata, cactus, angelica dahurica, purple duckweed, nine-returning-yang, cow hair felt, and stone lotus, into powder, to obtain the 11 herbs for later use, making sesame stalks into a charcoal agent, burning them until the outside is withered and black, and the inside is brown, and pounding the sesame stalks obtained after calcination into powder with a stone mortar to obtain sesame stalk calcined pounding powder for later use;

[0014] S8, mixing the sesame oil-soaked medicinal liquid and tung oil-boiled medicinal liquid obtained in S6, the pounded powders of the 11 medicinal herbs prepared in step S7, and the calcined sesame stalk pounded powders, and adding the licorice extract prepared in step S4 and the fermented salvia miltiorrhiza concentrate prepared in step S5 to mix and stir into a paste to obtain a Chinese medicine external application prescription;

[0015] Preferably: in step S3 of the present invention, the liquorice is processed with refined honey, and the property of the processed and modified liquorice changes from cool to warm, and the effect changes from clearing to warming, thus changing the original property of the liquorice.

[0016] Preferably, the concentration of the plant acid bacteria ATCC 8014 solution used in step S2 of the present invention is 1.21×10 8 cfu / ml.

[0017] Preferably, the concentration of the Bacillus subtilis ATCC 6633 bacterial solution used in step S2 of the present invention is 3.19×10 9 cfu / ml.

[0018] Preferably: the Lactobacillus plantarum ATCC 8014 used in step S2 of the present invention is purchased from Shandong Pingao Pharmaceutical Co., Ltd.

[0019] Preferably: the Bacillus subtilis ATCC 6633 used in step S2 of the present invention is purchased from Shandong Yitai Biotechnology Co., Ltd.

[0020] Preferably: in step S2 of the present invention, Lactobacillus plantarum and Bacillus subtilis are used to ferment the traditional Chinese medicine, in order to enhance the effect of the traditional Chinese medicine, obtain more beneficial substances in the traditional Chinese medicine, and enhance the anti-inflammatory and detoxification effects.

[0021] In a third aspect, the above-mentioned traditional Chinese medicine compress prescription for clearing away heat and detoxifying, treating and restoring deep burn skin is used alone or in combination with an oral prescription.

[0022] Preferably, when the Chinese medicine compress is used in conjunction with an internal prescription, the internal prescription comprises, by weight: 2 parts of honeysuckle, 3 parts of forsythia, 2 parts of wild chrysanthemum, 9 parts of patrinia herb, 3 parts of smilax glabra, and 2 parts of cyrtomium.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] 1. The present invention adopts plant lactobacillus ATCC 8014 and bacillus subtilis ATCC 6633 to have synergistic effect on fermentation of salvia miltiorrhiza, and the two are used simultaneously to effectively enhance the curative effect of Chinese medicine, so that the chemical components in salvia miltiorrhiza are transformed and improved, thereby changing its pharmacological action. Some flavonoid compounds in salvia miltiorrhiza can be converted into active ingredients with antioxidant and anti-inflammatory effects after fermentation, and fermentation changes the chemical structure in salvia miltiorrhiza, improves drug solubility, is easier to be absorbed and utilized by the human body, can also promote blood circulation and remove blood stasis, promote blood circulation, improve microcirculation disorders, and have very strong antioxidant and anti-inflammatory effects.

[0025] 2. The present invention processes liquorice, and the liquorice after processing and modification has its medicinal property changed from cool to warm, and its efficacy changed from clearing to warming, thus changing its original medicinal property.

[0026] 3. The stone mill used in step S6 of the present invention is used to squeeze and extract 30% of the standby liquid medicine of the whole medicine, thereby improving the efficacy of clearing away heat and detoxifying, relieving pain, killing insects, removing rotten toxins, and strengthening and promoting tissue regeneration in burns and scalds.

[0027] 4. In step S6 of the present invention, the remaining 70% of the liquid medicine is boiled with tung oil for later use. The cooked liquid medicine is a secondary process. The properties of the cooked medicine become tough and moisturizing, which can quickly regenerate tissue and heal the skin during the treatment of burns and scalds, making the skin smooth and moisturized.

[0028] 5. The present invention uses 11 kinds of medicines, each of which is pounded into powder and used to prepare a compress. During the treatment of burns and scalds, it can remove blood stasis and activate blood circulation, accelerate the function of muscle regeneration, and prevent tumors.

[0029] 6. In step S7 of the present invention, the sesame stalks are calcined and pounded into powder for later use, which has a significant effect on curing burns and scalds and restoring the patient's own skin.

[0030] 7. In the present invention, all the spare medicines are added together, sesame oil is added to prepare the liquid medicine, tung oil is added to boil the liquid medicine, 11 kinds of pounded powder medicines, sesame stalk calcined powder medicines, liquorice extract and salvia miltiorrhiza fermented concentrate are used, and a layer of ointment is stirred together. This step has a remarkable effect on the recovery of the entire burn and scald without scars.

[0031] 8. The Chinese medicine compress prepared by the present invention adopts 35 kinds of Chinese medicine and 2 kinds of vegetable oils, which play the effects of clearing away heat and detoxifying, relieving pain, killing insects, removing rotten toxins, consolidating and astringing, and promoting tissue regeneration, and there is no pruritus mark after recovery. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0033] Figure 1 The changes of SOD in the lung tissue of ALI rats after applying the traditional Chinese medicine prescription prepared by the present invention.

[0034] Figure 2 The changes of MPO in the lung tissue of ALI rats after applying the traditional Chinese medicine prescription prepared by the present invention.

[0035] Figure 3 Changes of MDA in lung tissue of ALI rats after applying the traditional Chinese medicine prescription prepared by the present invention. DETAILED DESCRIPTION

[0036] The following describes the implementation of the present invention through specific examples. Those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific implementations. The details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that the following embodiments and features in the embodiments can be combined with each other without conflict.

[0037] In the present invention, all raw Chinese medicines are commonly used Chinese medicines, which are recorded in detail in the "Chinese Pharmacopoeia" and "Chinese Materia Medica", and can be easily obtained through commercial channels. The present invention has no special restrictions on the origin of these Chinese medicinal materials, as long as they comply with relevant national standards or regulations.

[0038] The term "part(s)" in the present invention refers to parts by weight only. Specifically, any weight can be taken as 1 part, such as 0.001g, 0.01g, 0.05g, 0.1g, 0.5g, 1g, 10g, 100g, 1000g, 5000g, 10000g, etc.

[0039] Example 1

[0040] The present invention provides a Chinese medicine compress prescription for clearing away heat and detoxifying, treating and restoring deep burn skin, and the preparation method thereof is as follows:

[0041] S1. Take 5.5g of snake, 4.5g of Dioscorea bulbifera, 5.5g of Dioscorea chinensis, 7.5g of Leptospermum officinale, 5.5g of Artemisia selengensis, 4.5g of Seven-leafed Aristolochia, 4.5g of Toad Panax notoginseng, 7.5g of Mahonia, 7.5g of Rosa rugosa, 4.5g of Sour Plum Grass, 4.5g of Realgar Lotus, 5.5g of Three Needles, 7.5g of Horse Hoof Fragrance, 5.5g of Blood Scolopendra, 4.5g of Verbena, 7.5g of Sesame Stalk, 3.5g of Water Scolopendra, 4.5g of Iron Horse Root, 5.5g of Bletilla striata, 4.5g of Phoenix tail grass, 4.5g of Hedyotis diffusa, 4.5g of Opuntia dahurica, 7.5g of Acorus calamus, 7.5g of Rhizoma Atractylodis Macrocephalae, 5.5g of Herba Snakeheads, 4.5g of Angelica dahurica, 7.5g of Duckweed, 4.5g of Radix Stemonae, 4.5g of Herba Artemisiae Argyi, 4.5g of Caulis Loniceraes, 7.5g of Rhizoma Cibotii, 7.5g of Rhizoma Cibotii, 7.5g of Rhizoma Cibotii, 7.5g of Rhizoma Cibotii, 2.5g of Radix Glycyrrhizae, and 4.5g of Radix Salviae Miltiorrhizae were soaked in water for 1h respectively, all the soaked herbs were washed and dried, and then sterilized under high pressure at 0.1Mpa and 121℃ for 15min;

[0042] S2, prepared at a concentration of 1.25×10 8 cfu / ml of Lactobacillus plantarum ATCC 8014 bacterial solution, take 12ml and put it in a bacterial solution tank for later use; prepare a concentration of 3.25×10 9 cfu / ml of Bacillus subtilis ATCC 6633 bacterial solution, take 15 ml and place it in the bacterial solution tank containing Lactobacillus plantarum, so that the two bacterial solutions are mixed in the bacterial solution tank and standby after mixing;

[0043] S3, take the licorice treated in step S1, moisten it with pure water, cut it into thick slices, dry it, and obtain clean licorice slices, then dilute 8g of refined honey in a casserole filled with 35ml of boiling water, add the clean licorice slices after dilution, mix well, simmer thoroughly, and then fry it with a slow fire until it turns yellow and does not stick to the hands, take it out, and let it cool to obtain honey-refined licorice;

[0044] S4, add 150 mL of water to the honey-refined licorice obtained in step S3, soak for 32 minutes, place on an electromagnetic cooker and heat at a power of 2100 W, after boiling, change the power to 600 W, decoct for 20 minutes, filter out, add 200 mL of water during the second decoction, decoct for 15 minutes after boiling, cool after decoction, combine the two filtrates, concentrate the filtrate and make up to 25 mL to obtain a licorice extract;

[0045] S5, drying and crushing the processed Salvia miltiorrhiza in step S1, passing the crushed Salvia miltiorrhiza through a 50-mesh sieve, sterilizing it under high pressure and putting it into the bacterial liquid cylinder prepared in step S2, culturing it in a 28°C incubator for 30h, sterilizing and cooling it to room temperature to obtain a fermented Salvia miltiorrhiza, adding 8 times the amount of water to the fermented Salvia miltiorrhiza, decocting it for 1h, repeating it 2 times, combining the two filtrates, concentrating the filtrate and fixing the volume to 20mL, and obtaining a concentrated solution after the fermentation of Salvia miltiorrhiza for standby use;

[0046] S6, except for the medicinal materials obtained in step S1, including licorice, salvia miltiorrhiza, seven-leaf parsley, realgar root, horse hoof incense, sesame stalk, snake back, white striata, cactus, angelica dahurica, purple duckweed, nine-returning-yang, cow hair felt, and stone lotus, use a stone mortar to crush each medicine separately to loosen and no powder, add 20g sesame oil to boil and float three times, cool to 25°C, use an open container to brew and ferment the crushed loose medicine after sesame oil boiling, the fermentation time is to soak for 9 days in summer and autumn, then use a stone mill to squeeze and extract 30% of the whole medicine liquid, obtain sesame oil processing liquid, add 20g tung oil to boil the medicine into yellow and black with the residue of the whole medicine with 70% of the medicinal ingredients left, filter the extracted liquid with a sieve, cool to 18°C ​​for standby use, filter out the residue, and take out the remaining liquid to obtain tung oil boiled liquid;

[0047] S7, using a stone mortar to pound the 11 herbs washed in step S1, including seven-leaf parsley, realgar lotus, horse hoof fragrant, snakehead, white striata, cactus, angelica dahurica, purple duckweed, nine-returning-yang, cow hair felt, and stone lotus, into powder, to obtain the 11 herbs for later use, making sesame stalks into a charcoal agent, burning them until the outside is withered and black, and the inside is brown, and pounding the sesame stalks obtained after calcination into powder with a stone mortar to obtain sesame stalk calcined pounding powder for later use;

[0048] S8, mixing the sesame oil-soaked medicinal liquid and tung oil-boiled medicinal liquid obtained in S6, the pounded powders of the 11 medicinal herbs prepared in step S7, and the calcined sesame stalk pounded powders, adding the licorice extract prepared in step S4 and the fermented salvia miltiorrhiza concentrate prepared in step S5, and stirring them into a paste to obtain a Chinese medicine external application prescription;

[0049] Comparative Example 1: Except that Lactobacillus plantarum ATCC 8014 is replaced by Lactobacillus plantarum ATCC 33222 (Hubei Rishengchang New Material Technology Co., Ltd.) in step S5, the remaining steps are the same as those in Example 1.

[0050] Comparative Example 2: Except that Bacillus subtilis ATCC 6633 was replaced by ATCC 6051 (purchased from Weifang Yihao Biotechnology Co., Ltd.) in step S5, the remaining steps were the same as those in Example 1.

[0051] Comparative Example 3: In step S5, only Bacillus subtilis ATCC 6633 was used for fermentation, and the remaining steps were the same as those in Example 1.

[0052] Comparative Example 4: In step S5, only Lactobacillus plantarum ATCC 8014 was used for fermentation, and the remaining steps were the same as those in Example 1.

[0053] Comparative Example 5: Except that Salvia miltiorrhiza is not fermented in step S5, the remaining steps are the same as those in Example 1.

[0054] Comparative Example 6: Except that the licorice is not refined with honey in step S3, the remaining steps are the same as those in Example 1.

[0055] Embodiment 2:

[0056] The present invention provides a Chinese medicine compress prescription for clearing away heat and detoxifying, treating and restoring deep burn skin, and the preparation method thereof is as follows:

[0057] S1. Take 5.5g of snake, 4.5g of Dioscorea bulbifera, 5.5g of Dioscorea chinensis, 7.5g of Leptospermum officinale, 5.5g of Artemisia selengensis, 4.5g of Seven-leafed Aristolochia, 4.5g of Toad Panax notoginseng, 7.5g of Euonymus japonicus, 7.5g of Rosa rugosa, 4.5g of Sour Plum Grass, 4.5g of Realgar Lotus, 5.5g of Three Needles, 7.5g of Horse Hoof Fragrance, 5.5g of Blood Scolopendra, 4.5g of Verbena, 7.5g of Sesame Stalk, 3.5g of Water Scolopendra, 4.5g of Iron Horse Root, 5.5g of Bletilla striata, 4.5g of Phoenix tail grass, 4.5g of Hedyotis diffusa, 4.5g of Opuntia dahurica, 7.5g of Acorus calamus, 7.5g of Rhizoma Atractylodis Macrocephalae, 5.5g of Herba Snakeheads, 4.5g of Angelica dahurica, 7.5g of Duckweed, 4.5g of Radix Stemonae, 4.5g of Herba Artemisiae Argyi, 4.5g of Caulis Loniceraes, 7.5g of Rhizoma Cibotii, 7.5g of Rhizoma Cibotii, 7.5g of Rhizoma Cibotii, 7.5g of Rhizoma Cibotii, 2.5g of Radix Glycyrrhizae, and 4.5g of Radix Salviae Miltiorrhizae were soaked in water for 1h respectively, all the soaked herbs were washed and dried, and then sterilized under high pressure at 0.1Mpa and 121℃ for 15min;

[0058] S2, prepared at a concentration of 1.21×10 8 cfu / ml of Lactobacillus plantarum ATCC 8014 bacterial solution 10ml in a bacterial solution tank for use; the prepared concentration is 3.19×10 9 cfu / ml of Bacillus subtilis ATCC 6633 bacterial solution, take 12 ml and place it in the bacterial solution tank containing Lactobacillus plantarum, so that the two bacterial solutions are mixed in the bacterial solution tank and standby after mixing;

[0059] S3, take the licorice treated in step S1, moisten it with pure water, cut it into thick slices, dry it, and obtain clean licorice slices, then dilute 4g of refined honey in a casserole filled with 30ml of boiling water, add the clean licorice slices after dilution, mix well, simmer thoroughly, and then fry it with a slow fire until it turns yellow and does not stick to the hands, take it out, and let it cool to obtain honey-refined licorice;

[0060] S4, add 150 mL of water to the honey-refined licorice obtained in step S3, soak for 28 min, place on an electromagnetic cooker and heat at a power of 2100 W, after boiling, change the power to 600 W, decoct for 18 min, filter out, add 150 mL of water for the second decoction, decoct for 11 min after boiling, cool after decoction, combine the two filtrates, concentrate the filtrate and make up to 25 mL to obtain a licorice extract;

[0061] S5, drying and crushing the processed Salvia miltiorrhiza in step S1, passing the crushed Salvia miltiorrhiza through a 50-mesh sieve, sterilizing it under high pressure and placing it in the bacterial liquid cylinder prepared in step S2, culturing it in a 28°C incubator for 25h, sterilizing and cooling it to room temperature to obtain a fermented Salvia miltiorrhiza, adding 6 times the amount of water to the fermented Salvia miltiorrhiza, decocting it for 1h, repeating it 2 times, combining the two filtrates, concentrating the filtrate and fixing the volume to 20mL, and obtaining a concentrated solution after the fermentation of Salvia miltiorrhiza for standby use;

[0062] S6, except for the medicinal materials obtained in step S1, including licorice, salvia miltiorrhiza, seven-leaf parsley, realgar root, horse hoof incense, sesame stalk, back snake, white striata, cactus, angelica dahurica, purple back duckweed, nine rebirth, cattle hair felt, and stone lotus, use a stone mortar to crush each medicine separately to loosen and remove powder, add 15g sesame oil to boil and float three times, cool to 20°C, use an open container to brew and ferment the crushed loose medicine after sesame oil boiling, the fermentation time is to soak for 7 days in summer and autumn, and then use a stone mill to squeeze and extract 30% of the whole medicine liquid to obtain sesame oil preparation liquid; use the residue of the whole medicine with 70% of the medicinal ingredients left to boil the medicine with 15g tung oil to make it yellow and black, filter the extracted liquid with a sieve, cool it to 15°C for standby use, filter out the residue, and take out the remaining liquid to obtain tung oil boiled liquid;

[0063] S7, using a stone mortar to pound the 11 herbs washed in step S1, namely, Herba Lycopodii, Herba Cynanchifoliae, Herba Corydalis, Herba Bletillae, Herba Opuntiae, Herba Angelicae Dahuricae, Herba Lycopodii, Herba Echeveriae, Herba Echeveriae, Herba Echeveriae into powder, and prepare the 11 herbs for use; making charcoal from sesame stalks, burning them until the outside is withered and black, and the inside is brown; pounding the sesame stalks obtained after calcination into powder using a stone mortar to obtain calcined sesame stalks for use;

[0064] S8, mixing the sesame oil-soaked medicinal liquid and tung oil-boiled medicinal liquid obtained in S6, the pounded powders of the 11 medicinal herbs prepared in step S7, and the calcined sesame stalk pounded powders, adding the licorice extract prepared in step S4 and the fermented salvia miltiorrhiza concentrate prepared in step S5, and stirring them into a paste to obtain a Chinese medicine external application prescription;

[0065] The Chinese medicine compress obtained in this embodiment is also used in conjunction with an internal prescription. The internal prescription comprises: 2g of honeysuckle, 3g of forsythia, 2g of wild chrysanthemum, 9g of patrinia, 3g of smilax glabra, and 2g of rhizoma cyrtonema. The preparation method of the internal prescription is: weigh each medicinal material according to the formula, add 6 times the amount of water to decoct, repeat 3 times, combine the filtrate and concentrate the volume to 60ml.

[0066] Embodiment 3:

[0067] The present invention provides a Chinese medicine compress prescription for clearing away heat and detoxifying, treating and restoring deep burn skin, and the preparation method thereof is as follows:

[0068] S1. Take 5.5g of snake, 4.5g of Dioscorea bulbifera, 5.5g of Dioscorea chinensis, 7.5g of Leptospermum officinale, 5.5g of Artemisia selengensis, 4.5g of Seven-leafed Aristolochia, 4.5g of Toad Panax notoginseng, 7.5g of Euonymus japonicus, 7.5g of Rosa rugosa, 4.5g of Sour Plum Grass, 4.5g of Realgar Lotus, 5.5g of Three Needles, 7.5g of Horse Hoof Fragrance, 5.5g of Blood Scolopendra, 4.5g of Verbena, 7.5g of Sesame Stalk, 3.5g of Water Scolopendra, 4.5g of Iron Horse Root, 5.5g of Bletilla striata, 4.5g of Phoenix tail grass, 4.5g of Hedyotis diffusa, 4.5g of Opuntia dahurica, 7.5g of Acorus calamus, 7.5g of Rhizoma Atractylodis Macrocephalae, 5.5g of Herba Snakeheads, 4.5g of Angelica dahurica, 7.5g of Duckweed, 4.5g of Radix Stemonae, 4.5g of Herba Artemisiae Argyi, 4.5g of Caulis Loniceraes, 7.5g of Rhizoma Cibotii, 7.5g of Rhizoma Cibotii, 7.5g of Rhizoma Cibotii, 7.5g of Rhizoma Cibotii, 2.5g of Radix Glycyrrhizae, and 4.5g of Radix Salviae Miltiorrhizae were soaked in water for 1h respectively, all the soaked herbs were washed and dried, and then sterilized under high pressure at 0.1Mpa and 121℃ for 15min;

[0069] S2, prepared at a concentration of 1.23×10 8 cfu / ml of Lactobacillus plantarum ATCC 8014 bacterial solution, take 11ml and put it in a bacterial solution tank for later use; prepare a concentration of 3.22×10 9 cfu / ml of Bacillus subtilis ATCC 6633 bacterial solution, take 12 ml and place it in the bacterial solution tank containing Lactobacillus plantarum, so that the two bacterial solutions are mixed in the bacterial solution tank and standby after mixing;

[0070] S3, take the licorice treated in step S1, moisten it with pure water, cut it into thick slices, dry it, and obtain clean licorice slices, then dilute 6g of refined honey in a casserole filled with 32ml of boiling water, add the clean licorice slices after dilution, mix well, simmer thoroughly, and then fry it with slow fire until it turns yellow and does not stick to the hands, take it out, and let it cool to obtain honey-refined licorice;

[0071] S4, add 150 mL of water to the honey-refined licorice obtained in step S3, soak for 30 min, place on an electromagnetic cooker and heat at a power of 2100 W, after boiling, change the power to 600 W, decoct for 19 min, filter out, add 170 mL of water for the second decoction, decoct for 13 min after boiling, cool after decoction, combine the two filtrates, concentrate the filtrate and make up to 25 mL to obtain a licorice extract;

[0072] S5, drying and crushing the processed Salvia miltiorrhiza in step S1, passing the crushed Salvia miltiorrhiza through a 50-mesh sieve, sterilizing it under high pressure and putting it into the bacterial liquid cylinder prepared in step S2, culturing it in a 28°C incubator for 25h, sterilizing and cooling it to room temperature to obtain a fermented Salvia miltiorrhiza, adding 7 times the amount of water to the fermented Salvia miltiorrhiza, decocting it for 1h, repeating it 2 times, combining the two filtrates, concentrating the filtrate and fixing it to 20mL, and obtaining a concentrated solution after the fermentation of Salvia miltiorrhiza for standby use;

[0073] S6, except for the medicinal materials obtained in step S1, including licorice, salvia miltiorrhiza, seven-leaf parsley, realgar root, horse hoof incense, sesame stalk, back snake, white striata, cactus, angelica dahurica, purple back duckweed, nine rebirth, cattle hair felt, and stone lotus, use a stone mortar to crush each medicine separately to loosen and remove powder, add 17g sesame oil to boil and float three times, cool to 22°C, use an open container to brew and ferment the crushed loose medicine after sesame oil boiling, the fermentation time is to soak for 8 days in summer and autumn, and then use a stone mill to squeeze and extract 30% of the whole medicine liquid to obtain sesame oil preparation liquid; use the residue of the whole medicine with 70% of the medicinal ingredients left to boil the medicine with 18g tung oil to make it yellow and black, filter the extracted liquid with a sieve, cool it to 17°C for standby use, filter out the residue, and take out the remaining liquid to obtain tung oil boiled liquid;

[0074] S7, using a stone mortar to pound the 11 herbs washed in step S1, including seven-leaf parsley, realgar lotus, horse hoof fragrant, back snake, white striata, cactus, angelica dahurica, purple back duckweed, nine rebirths, cow hair felt, and stone lotus, into powder to obtain 11 herbs for later use; making sesame stalks into a charcoal agent, burning them until the outside is dry and black, and the inside is brown, and pounding the sesame stalks obtained after calcination into powder with a stone mortar to obtain sesame stalk calcined pounding powder for later use;

[0075] S8, mixing the sesame oil-soaked medicinal liquid and tung oil-boiled medicinal liquid obtained in S6, the pounded powders of the 11 medicinal herbs prepared in step S7, and the calcined sesame stalk pounded powders, adding the licorice extract prepared in step S4 and the fermented salvia miltiorrhiza concentrate prepared in step S5, and stirring them into a paste to obtain a Chinese medicine external application prescription;

[0076] Comparative Example 7: Except that the sesame stems are not subjected to forging treatment but are directly ground into powder in step S7, the remaining steps are the same as those in Example 3.

[0077] Comparative Example 8: The drug residue with 70% of the medicinal ingredients remaining after processing the entire drug and 18g of tung oil was used to boil the drug in step S6, and 18g of sesame oil was used instead. The remaining steps were the same as in Example 3.

[0078] 1. Effects of Chinese herbal compresses on lipopolysaccharide-induced acute lung injury in rats

[0079] Experimental methods:

[0080] 1. Animal handling and grouping:

[0081] Healthy male Wistar rats, weighing 280-300g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. They were kept for 3 days before the experiment to adapt to the environment, and were given rat feed and free drinking water. The rats were randomly divided into 11 groups, namely the normal group, the model group, the embodiment 1-3 groups and the comparative example 1-6 groups, 5 rats in each group, a total of 55 rats. The abdomen of all rats was depilated before the experiment. Except for the normal group, the other groups were all used for model rat experiments.

[0082] 2. Establishment of rat model of acute lung injury (ALI) induced by lipopolysaccharide (LPS):

[0083] After the rats were anesthetized by intraperitoneal injection of sodium pentobarbital (50 mg / kg), the rats in the embodiment group and the comparative group were instilled with 5 mg / kg LPS poisoning in the trachea by a one-time tracheal puncture method. Method: The rats were fixed in a head-high position with an inclination angle of 60°, and the trachea was punctured at the cricoid cartilage with a No. 9 injection needle, and the LPS solution diluted with sodium chloride injection (LPS was purchased from Sigma-Aldrich, USA) was slowly instilled, with an instillation volume of 2 ml / kg and an instillation time of ≥15 s to prevent suffocation; the rats in the model group and the normal group of the positive control group were instilled with an equal volume of sodium chloride injection in the same way.

[0084] 3. Drug administration in nursing experiments:

[0085] The acute lung injury (ALI) model was successfully established 4 hours after administration. The rats in the normal group and the model group were injected with 10 ml / kg of normal saline of the same volume; the rats in the Example 1-3 group and the Comparative Example 1-6 group were respectively smeared with the corresponding ointment on the depilated part of the abdomen, and the ointment was applied at a dose of 150 mg / kg, and the drug was administered once / d for 7 consecutive days; among them, on the basis of applying the ointment, the oral prescription was administered by gavage in Example 2, and the oral prescription dose was 10 ml / kg, once / day, for 7 consecutive days. The specific medication is shown in Table 1; after the last gavage or application, fasting for 8 hours, and alveolar lavage fluid and bilateral lung tissue were collected for subsequent experiments.

[0086] 4. Bronchoalveolar lavage fluid (BALF) collection:

[0087] After the last administration, the rats were fasted for 8 hours, anesthetized, and the trachea was exposed by midline incision of the neck. After blunt dissection, a 1 ml syringe connected to a hose of an indwelling needle was inserted into the trachea, and air leakage was minimized. The right lung was lavaged 4 times with 1 ml of pre-cooled phosphate buffered saline (PBS) injected with a syringe. During the lavage process, the chest cavity was gently massaged to obtain about 3.2 ml of bronchoalveolar lavage fluid, which was centrifuged at 4 ° C, 3000 r / min for 15 min, and the supernatant was obtained and stored at -80 ° C.

[0088] 5. Lung tissue collection: After the rats were killed, they were fixed in supine position on a sterile operating table. The neck, chest, and abdomen were disinfected with ethanol. The thorax was opened aseptically and the complete lungs were removed. The left lung tissue was stored at -80°C.

[0089] Detection Methods

[0090] 1. Determination of the content of (TNF-α, IL-6, IL-1β) in bronchoalveolar lavage fluid BALF:

[0091] The contents of IL-6, TNF-α, and IL-1β in BALF were detected by enzyme-linked immunosorbent assay. The contents of IL-6, TNF-α, and IL-1β in BALF were detected strictly according to the instructions of the kit, and the results are shown in Table 2. Among them, IL-6 and IL-1β ELISA detection kits were purchased from Shanghai Biyuntian Biotechnology Co., Ltd.; TNF-α ELISA detection kits were purchased from Wuhan Boster Biotechnology Co., Ltd.

[0092] 2. Detection of SOD, MPO and MDA content in lung tissue

[0093] The lung tissue of the left lung was homogenized with cold physiological saline at a ratio of 1:9 (mass to volume ratio), and the supernatant was collected by centrifugation at 8000 rpm for 5 min. The protein content in the supernatant was quantified by the BCA method. According to the instructions, the MPO, SOD and MDA content in the supernatant were detected by the corresponding ELISA kit; the protein content was then used to quantify the corresponding indicators in the lung tissue. The results are shown in the figure. Figure 1 , Figure 2 and Figure 3 Among them, MPO, SOD, and MDA detection kits were purchased from Nanjing Jiancheng Bioengineering Institute.

[0094] Table 1 Grouping and drug dosage of rats with acute lung injury

[0095]

[0096]

[0097] Table 2 Contents of TNF-α, IL-6 and IL-1β in bronchoalveolar lavage fluid of rats in each group

[0098]

[0099] The experimental results in Table 2 show that compared with the normal group, the content of TNF-α, IL-6, and IL-1β inflammatory mediators in the bronchoalveolar lavage fluid of the model group rats increased. After treatment with the Chinese medicine compress prepared by the present invention, the content of inflammatory mediators TNF-α, IL-6, and IL-1β in the rats of the embodiment group decreased significantly. The content of inflammatory mediators TNF-α, IL-6, and IL-1β in the comparative example decreased but not significantly. After the intervention of the Chinese medicine compress and the treatment of the oral prescription in Example 2, the content of inflammatory mediators TNF-α, IL-6, and IL-1β in the bronchoalveolar lavage fluid of the rats decreased significantly, and the treatment effect was better than that of other groups. It is suggested that the use of the Chinese medicine compress prepared by the present invention during treatment can improve the efficacy, alleviate clinical symptoms, reduce the level of inflammatory mediators, and improve neurological function, and on this basis, the effect can be increased by coordinating the oral prescription treatment.

[0100] Depend on Figure 1 , Figure 2 , Figure 3 It can be seen that compared with the normal group, the MPO activity and MDA content of the lung tissue of the model group were significantly increased, and the SOD activity was significantly decreased; compared with the model group, the embodiment group and the comparative example group reduced the MPO activity and MDA content of the lung tissue of ALI rats, and increased the SOD activity; compared with comparative examples 1-6, the MPO activity and MDA content of the lung tissue of the embodiment group were more significantly reduced, and the SOD activity was more significantly increased. The effect of the embodiment group was significantly higher than that of the comparative example group, and the effect of the embodiment group 2, which used both Chinese medicine compresses and oral medications, was slightly better than that of embodiments 1 and 3.

[0101] Inflammatory response is one of the important characteristics of ALI. This study showed that Chinese herbal compress can reduce the MPO activity and MDA content in the lung tissue of ALI rats, and increase the activity of SOD, suggesting that Chinese herbal compress has the effect of clearing away heat and detoxifying, and is suitable for reducing LPS-induced oxidative stress.

[0102] 2. Experiment on the treatment of deep burns with Chinese herbal compresses

[0103] (1) Experimental methods:

[0104] 1. Burn treatment:

[0105] 70 C57BL / 6J mice were purchased from Liaoning Changsheng Biotechnology Co., Ltd., half male and half female, 6-8 weeks old. The mice were allowed to fully adapt to the environment for 1 week before the experiment, and they had free access to feed and water. After anesthesia, the mice were fixed on the surgical board in a prone position, the back skin was fully exposed, and the limbs were fixed. The back skin of the mice was repeatedly wiped with 1% iodine cotton balls, and the hair on the back of the mice was gently shaved with a stainless steel double-sided blade clamped with a needle holder. After skin preparation, the back skin was wiped with 1% iodine again 2-3 times. A brass probe with a diameter of 8mm was used to induce full-thickness contact burns on the back skin of the mice. The temperature of the brass probe was set to 300℃ and contacted the skin for 2-3 seconds. After injury, the mice were intraperitoneally injected with 0.9% sodium chloride for fluid resuscitation. The recovery of the mice was closely observed within 2 hours after injury, and the vital signs of the mice were closely observed within 24-48 hours. After burns, the mice were housed separately according to their respective experimental groups, with free access to food and water.

[0106] 2. Post-burn care:

[0107] After the mice woke up from anesthesia, they were able to move freely and eat normally, indicating that the modeling was successful. The mice with successful burn model construction were randomly divided into: model group, positive control group, Example 1-3 group, Comparative Example 1-8 group, 5 mice in each group, a total of 13 groups, and 5 mice were randomly selected as the normal group. The temperature of the brass probe was set to 37°C in the normal group, and the rest were treated with the same method as the burn model construction; after the scald, the wound was locally disinfected with iodine tincture, and the positive control group was smeared with sulfadiazine silver cream, which was directly applied to the wound, with a thickness of about 1.5mm; the mice in Example 1-3 group and Comparative Example 1-8 group were respectively smeared with corresponding ointments, which were directly applied to the wound, with a thickness of about 1.5mm, and the wound was disinfected once every 2 days, and the corresponding drugs were replaced, and the treatment was 4 weeks in total. The wounds of mice in the normal group and the model group were disinfected once every 2 days, and no medicine was applied. Among them, Example 2 was based on the application of ointment, and the oral prescription was administered, and the dosage of the oral prescription was 10ml / kg, once a day.

[0108] 3. Collection of materials:

[0109] The measurement method mainly uses standard transparent squares to measure and scan into the computer, and then uses ImageJ image analysis software to calculate the wound area and the wound healing area ratio. Starting from the wound, the wound area of ​​the back of the mouse was evaluated on the 0th, 7th, 14th, 21st, and 28th day of intervention. The camera was fixed with a tripod, the distance between the camera and the mouse was fixed each time, and the appropriate light source was selected to ensure that the multiple dependent variables were the same as much as possible. After taking pictures, the digitized wound photos were used by ImageJ software (NIH, Bethesda, MD) to measure the wound area at different time points to evaluate the wound healing rate.

[0110] (2) Detection indicators and methods

[0111] 1. Wound healing rate calculation method: Healing rate (%) = (SD0-SD 天数 ) / SD0×100%, where SD0 represents the wound area before treatment, SD 天数 Indicates the wound area after a certain number of days of treatment; the results are shown in Table 3.

[0112] Table 3 Comparison of wound healing rate (%) of mice at different time

[0113]

[0114] As shown in Table 3, compared with Comparative Examples 1-8, it can be seen that the wound healing ratio of Example 1 is larger and the speed is faster, which further proves the particularity of the fermentation strain of Salvia miltiorrhiza. Only the concentrated solution of Salvia miltiorrhiza fermented by the combined fermentation of Lactobacillus plantarum ATCC 8014 and Bacillus subtilis ATCC 6633 has good heat-clearing and detoxicating and burn-treating effects. Compared with Comparative Examples 5 and 6, it is obvious that Example 1 has good effects in terms of speed and area of ​​treatment. The obtained experimental results can prove that the concentrated solution of Salvia miltiorrhiza fermented, Licorice extract and other Chinese medicine ingredients produce synergistic effects together, and the effects of heat-clearing and detoxicating and burn-treating are remarkable. Compared with Comparative Examples 7 and 8, the healing effect of Example 1 is significantly increased, indicating the importance of sesame stalk forging and storage treatment, and also embodies that the tung oil decoction liquid makes the effective ingredients in Chinese medicine fully boiled out, and then its heat-clearing and detoxicating and burn-treating effects increase.

[0115] The above is only a preferred specific implementation of the present application, but the protection scope of the present application is not limited thereto. Any changes or substitutions that can be easily conceived by any technician familiar with the technical field within the technical scope disclosed in the present application should be covered within the protection scope of the present application.

Claims

1. A Chinese medicine compress for clearing away heat and detoxifying, treating and restoring deep burns on the skin. It is characterized in that The content by weight is as follows: 5.5 parts of snake, 4.5 parts of Dioscorea bulbifera, 5.5 parts of Dioscorea chinensis, 7.5 parts of Hedyotis diffusa, 5.5 parts of Artemisia selengensis, 4.5 parts of Polygonum multiflorum, 4.5 parts of Radix Notoginseng, 7.5 parts of Mahonia, 7.5 parts of Rosaceae, 4.5 parts of Sour Plum Grass, 4.5 parts of Realgar Lotus, 5.5 parts of Three Needles, 7.5 parts of Horse Hoof Fragrance, 5.5 parts of Blood Scolopendra, 4.5 parts of Verbena, 7.5 parts of Sesame Stalks, 3.5 parts of Water Scolopendra, 4.5 parts of Iron Horse Root, 5.5 parts of Bletilla striata, 4.5 parts of Pteris sutchuenensis, 4.5 parts of Hedyotis diffusa, The invention comprises the following steps: 4.5 parts of cactus, 7.5 parts of calamus, 7.5 parts of needle needle, 5.5 parts of snake root, 4.5 parts of angelica dahurica, 7.5 parts of duckweed, 4.5 parts of stemona, 4.5 parts of herba scutellariae, 4.5 parts of honeysuckle, 7.5 parts of radix nigra, 7.5 parts of ox hair felt, 7.5 parts of echeveria, 2.5 parts of liquorice, 4.5 parts of salvia miltiorrhiza, 15-20 parts of sesame oil and 15-20 parts of tung oil; wherein the liquorice is refined with honey and then subjected to water extraction treatment; the salvia miltiorrhiza is soaked in 75% ethanol and then dried and crushed, and then fermented and extracted by using a composite strain.

2. A Chinese medicine compress for clearing away heat and detoxifying and treating deep burns of the skin according to claim 1, It is characterized in that The composite strain comprises Lactobacillus plantarum ATCC 8014 and Bacillus subtilis ATCC 6633.

3. A method for preparing a Chinese medicine compress for clearing away heat and detoxifying and treating deep burn skin restoration as claimed in any one of claim 2, It is characterized in that The specific preparation method is as follows: S1. Take snake but not more than 5.5g, yellow medicine 4.5g, ground brocade 5.5g, eight angle lotus 7.5g, one wormwood 5.5g, seven leaf aconite 4.5g, toad Panax notoginseng 4.5g, ten great magnolia 7.5g, golden cherry 7.5g, sour plum grass 4.5g, realgar lotus 4.5g, three needles 5.5g, horse hoof incense 7.5g, blood centipede 5.5g, verbena 4.5g, sesame stalk 7.5g, water centipede 3.5g, iron horse root 4.5g, white 5.5g, phoenix tail grass 4.5g, white flower 4.5g of Hedyotis diffusa, 4.5g of Opuntia cochinchinensis, 7.5g of Acorus calamus, 7.5g of Rhizoma Atractylodis Macrocephalae, 5.5g of Herba Epimedii, 4.5g of Angelica dahurica, 7.5g of Duckweed, 4.5g of Radix Stemonae, 4.5g of Herba Artemisiae Argyi, 4.5g of Caulis Loniceraes, 7.5g of Rhizoma Cibotii, 7.5g of Rhizoma Cibotii, 7.5g of Echeveria, 2.5g of Radix Glycyrrhizae, and 4.5g of Radix Salviae Miltiorrhizae were soaked in water for 1-1.5h respectively, and all the soaked herbs were washed and dried, and then sterilized under high pressure at 0.1Mpa and 121℃ for 15min; S2, prepared at a concentration of 1.21×10 8 ~1.25×10 8 cfu / ml of Lactobacillus plantarum ATCC 8014 bacterial solution, take 10-12 ml into a bacterial solution container for later use; prepare a concentration of 3.19×10 9 ~3.25×10 9 cfu / ml of Bacillus subtilis ATCC6633 bacterial solution, take 12-15 ml and put it into the bacterial solution tank containing Lactobacillus plantarum, so that the two bacterial solutions are mixed in the bacterial solution tank, and then standby after mixing; S3, take the licorice treated in step S1, moisten it with pure water, cut it into thick slices, dry it, and obtain clean licorice slices, then dilute 4-8g of refined honey in a casserole filled with 30-35ml of boiling water, add the clean licorice slices after dilution, mix well, simmer thoroughly, and then fry it with a slow fire until it turns yellow and does not stick to the hands, take it out, and let it cool to obtain honey-refined licorice; S4, add 150 mL of water to the honey-refined licorice obtained in step S3, soak for 28 to 32 minutes, place on an electromagnetic cooker and heat at a power of 2100 W, after boiling, change the power to 600 W, decoct for 18 to 20 minutes, filter out, add 150 to 200 mL of water during the second decoction, decoct for 11 to 15 minutes after boiling, cool after decoction, combine the two filtrates, concentrate the filtrate and make up to 25 mL to obtain a licorice extract; S5, drying and crushing the processed Salvia miltiorrhiza in step S1, passing the crushed Salvia miltiorrhiza through a 50-mesh sieve, sterilizing it under high pressure and putting it into the bacterial liquid cylinder prepared in step S2, culturing it in a 28°C incubator for 25-30h, sterilizing and cooling it to room temperature to obtain a fermented Salvia miltiorrhiza, adding 6-8 times the amount of water to the fermented Salvia miltiorrhiza, decocting it for 1h, repeating it twice, combining the filtrate, concentrating the filtrate and fixing it to 20mL, obtaining a concentrated solution after the fermentation of Salvia miltiorrhiza, and setting it aside; S6, except for the medicinal materials obtained in step S1, such as liquorice, salvia miltiorrhiza, seven-leaf parsnip, realgar root, horse hoof fragrance, sesame stalk, snake root, bletilla striata, cactus, angelica dahurica, purple duckweed, nine-returning yang, cow hair felt, and stone lotus, use a stone mortar to crush each medicine separately to loosen and remove powder, add 15-20g sesame oil, boil and float three times, cool to 20-25°C, use an open container to soak and ferment the loose medicine after sesame oil boiling, the fermentation time is 15-17 days in winter and spring, or 7-9 days in summer and autumn, and then use a stone mill to squeeze and extract 30% of the whole medicine liquid to obtain sesame oil preparation liquid; The residue of the whole medicine with 70% of the medicinal ingredients remaining is added with 15-20g of tung oil to boil the medicine into yellow-black color, and the extracted liquid is filtered with a sieve and cooled to 15-18°C for use, the residue is filtered out, and the remaining liquid is taken out to obtain the tung oil boiled liquid; S7, using a stone mortar to pound the 11 herbs washed in step S1, including seven-leaf parsley, realgar root, horse hoof incense, snake herb, white striata, cactus, angelica dahurica, purple duckweed, nine-returning-yang, cow hair felt, and stone lotus, into powder separately, and the pounded powders of the 11 herbs are set aside; sesame stalks are made into a charcoal agent, burned until the outside is withered and black, and the inside is browned, and the sesame stalks obtained after calcination are pounded into powder with a stone mortar to obtain sesame stalk calcined pounded powder for later use; S8. Mix the sesame oil-soaked medicinal liquid and tung oil-boiled medicinal liquid obtained in S6, the pounded powders of the 11 medicinal herbs and the calcined sesame stalk powders prepared in step S7, add the licorice extract prepared in step S4 and the fermented salvia miltiorrhiza concentrate prepared in step S5, and mix and stir into a paste to obtain a traditional Chinese medicine external application prescription.

4. A method for preparing a Chinese medicine compress for clearing away heat and detoxifying and treating deep burns of the skin according to claim 3, Features: The concentration of the Lactobacillus plantarum ATCC 8014 bacterial solution used in step S2 of the present invention is 1.21×10 8 cfu / ml.

5. A method for preparing a Chinese medicine compress for clearing away heat and detoxifying and treating deep burns of the skin according to claim 3, Features: The concentration of the Bacillus subtilis ATCC 6633 bacterial solution used in step S2 of the present invention is 3.19×10 9 cfu / ml.

6. A method for preparing a Chinese medicine compress for clearing away heat and detoxifying and treating deep burns of the skin according to claim 3, Features: Add 150 mL of water to the honey-refined licorice obtained in step S3, soak for 32 minutes, place on an induction cooker and heat at a power of 2100 W. After boiling, change the power to 600 W, boil for 20 minutes, filter out, add 200 mL of water for the second decoction, boil for 15 minutes after boiling, and cool after decoction.

7. Use of a Chinese medicinal compress for clearing away heat and detoxifying and treating deep burns as claimed in any one of claims 1 to 2 or a Chinese medicinal compress for clearing away heat and detoxifying and treating deep burns as claimed in any one of claims 3 to 6 to obtain a Chinese medicinal compress, It is characterized in that Chinese medicine compresses can be used alone or in combination with oral prescriptions.

8. The use according to claim 7, It is characterized in that When the Chinese medicine compress is used in conjunction with an internal prescription, the internal prescription comprises, by weight: 2 parts of honeysuckle, 3 parts of forsythia, 2 parts of wild chrysanthemum, 9 parts of patrinia herb, 3 parts of smilax glabra, and 2 parts of cyrtomium.

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