Traditional Chinese medicine composition for relieving lumbago, traditional Chinese medicine preparation and preparation method and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for relieving lumbago, a traditional Chinese medicine preparation and a preparation method and application thereof. The traditional Chinese medicine composition contains rheum officinale, pinellia ternate, cape jasmine, coptis chinensis, goat bones, cucumber seeds, prepared kusnezoff monkshood roots, curcuma zedoary, ground beetles, artemisia rupestris, frankincense, myrrh and liquorice. The preparation method of the traditional Chinese medicine preparation for relieving lumbago comprises the following steps: mixing a mixture A of rheum officinale, pinellia ternate, cape jasmine, coptis chinensis, goat bones and cucumber seeds with a solvent containing monohydric alcohol, carrying out alcohol extraction for at least one time, and collecting an alcohol extract; and mixing the mixture B of prepared kusnezoff monkshood root, curcuma zedoary, ground beetle, artemisia rupestris, frankincense, myrrh and liquorice with water, decocting for at least one time, and performing solid-liquid separation to obtain the water extract. The invention also provides application of the traditional Chinese medicine composition prepared by the method or the traditional Chinese medicine preparation prepared by the method in medicines for relieving back pain. The traditional Chinese medicine composition has the effects of relieving pain, diminishing swelling, dredging collaterals and strengthening tendons and bones.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition and a traditional Chinese medicine preparation for relieving low back pain, as well as a preparation method and application thereof. Background Art

[0002] In daily life, intervertebral disc disease is one of the main causes of low back pain, and lumbar facet arthritis is another important cause of long-term chronic low back pain; after the intervertebral disc undergoes different degrees of degeneration, its nucleus pulposus can protrude through the ruptured annulus fibrosus and stimulate the nerve root to cause LBP (low back pain). In the current existing technology, Western medicine usually uses anti-inflammatory and analgesic, hormone, blockade, ultraviolet irradiation, traction, surgery and other methods to treat low back pain. Its disadvantages are that it only treats the symptoms but not the root cause, the treatment time is long, the effect is not obvious, the cost is high, and the operation is extremely dangerous.

[0003] People often use plasters to treat or relieve low back pain. Plasters have the advantages of being easy to use and the efficacy of the drug can directly reach the affected area. However, the existing plasters for treating low back pain are often not ideal for low back pain caused by intervertebral disc lesions, low back pain caused by lumbar arthritis, and low back pain caused by different degrees of intervertebral disc degeneration. In addition, generally one drug is only effective for one symptom, and there are also disadvantages such as the drug effect cannot be sustained, rebound is likely to occur after stopping the drug, and long-term uninterrupted use is required. Summary of the invention

[0004] The purpose of the present invention is to overcome the problems of poor therapeutic effect, single efficacy and easy rebound in the prior art, and to provide a Chinese medicine composition for relieving low back pain, a Chinese medicine preparation and a preparation method and application thereof. The Chinese medicine composition for relieving low back pain has the advantages of good therapeutic effect, wide application range and not easy rebound. The Chinese medicine composition for relieving low back pain of the present invention acts on the painful part of the waist, has a long-lasting efficacy, is simple to operate and has no side effects.

[0005] In order to achieve the above-mentioned object, the first aspect of the present invention provides a traditional Chinese medicine composition for relieving low back pain, which contains rhubarb, pinellia, gardenia, coptis, goat bone, cucumber seed, processed aconite, zedoaria, earthworm, artemisia selengensis, frankincense, myrrh and licorice.

[0006] Preferably, relative to 100 parts by weight of rhubarb, the content of Pinellia is 30-50 parts by weight, the content of Gardenia is 70-90 parts by weight, the content of Coptis chinensis is 10-30 parts by weight, the content of goat bone is 10-30 parts by weight, the content of cucumber seeds is 10-30 parts by weight, the content of processed Aconitum carmichaelii is 10-20 parts by weight, the content of Curcuma zedoaria is 10-20 parts by weight, the content of Eupolyphaga sinensis is 10-20 parts by weight, the content of Artemisia striata is 90-120 parts by weight, the content of frankincense is 30-50 parts by weight, the content of Myrrh is 30-50 parts by weight, and the content of Licorice is 10-20 parts by weight.

[0007] A second aspect of the present invention provides a method for preparing a Chinese medicine preparation for relieving low back pain, the method comprising the following steps:

[0008] (1) mixing a mixture A of rhubarb, pinellia, gardenia, coptis, goat bone and cucumber seed with a solvent containing a monohydric alcohol, performing alcohol extraction at least once, and collecting an alcohol extract;

[0009] Mixing a mixture B of processed Aconitum, Curcuma, Eupolyphaga, Artemisia selengensis, Frankincense, Myrrh and Licorice with water, performing at least one decoction, and performing solid-liquid separation to obtain a water extract;

[0010] (2) Mixing the alcohol extract and the water extract obtained in step (1).

[0011] Preferably, relative to 100 parts by weight of rhubarb, the content of Pinellia is 30-50 parts by weight, the content of Gardenia is 70-90 parts by weight, the content of Coptis chinensis is 10-30 parts by weight, the content of goat bone is 10-30 parts by weight, the content of cucumber seeds is 10-30 parts by weight, the content of processed Aconitum carmichaelii is 10-20 parts by weight, the content of Curcuma zedoaria is 10-20 parts by weight, the content of Eupolyphaga sinensis is 10-20 parts by weight, the content of Artemisia striata is 90-120 parts by weight, the content of frankincense is 30-50 parts by weight, the content of Myrrh is 30-50 parts by weight, and the content of Licorice is 10-20 parts by weight.

[0012] Preferably, the alcohol extraction step in step (1) comprises: mixing and soaking the mixture A with the solvent containing the monohydric alcohol.

[0013] More preferably, the monohydric alcohol is selected from at least one of C1-C3 monohydric alcohols, and more preferably is ethanol.

[0014] Preferably, the solvent containing monohydric alcohol is a mixture of monohydric alcohol and water, and in the mixture of monohydric alcohol and water, the volume percentage of the monohydric alcohol is 20-95%.

[0015] Further preferably, the conditions for the alcohol extraction include at least: a temperature of 25-45°C and a time of 1-2h.

[0016] Further preferably, relative to 1 kg of the mixture A, the amount of the monohydric alcohol used is 1-5 L.

[0017] Preferably, the method further comprises: mixing and soaking the mixture B with water before the decocting.

[0018] More preferably, the soaking time is 30-60 min.

[0019] Further preferably, the decocting conditions include: a temperature of 80-100° C. and a time of 15-30 min.

[0020] Further preferably, relative to 1 kg of the mixture B, the amount of the solvent containing the monohydric alcohol is 1-5 L.

[0021] Preferably, the step (2) further comprises: before the mixing, respectively concentrating the alcohol extract and the water extract under reduced pressure.

[0022] The third aspect of the present invention provides a Chinese medicine preparation prepared according to the preparation method described in the second aspect.

[0023] The fourth aspect of the present invention provides a use of the Chinese medicine composition described in the first aspect or the Chinese medicine preparation prepared according to the preparation method described in the second aspect in a medicine for relieving low back pain.

[0024] Through the above technical solution, the beneficial effects of the present invention are:

[0025] The Chinese medicine composition provided by the present invention has a scientific and excellent formula. Rhubarb is cold in nature, bitter in taste, and enters the spleen, stomach, large intestine, liver, and pericardium meridians, and has the effects of purging heat and clearing the intestines, cooling blood and detoxifying, and removing blood stasis and dredging menstruation, and is used as the main medicine. Pinellia tuber is pungent and warm, enters the spleen, stomach, and lung meridians, and can dry dampness and resolve phlegm, reduce adverse reactions and stop vomiting, and eliminate lumps and resolve knots, and is used as the assistant medicine. Gardenia jasminoides is bitter and cold, and enters the heart, lung, and triple burner meridians, and can purge fire and relieve restlessness, clear heat and remove dampness, cool blood and detoxify, and can be used externally to relieve swelling and relieve pain. The ingredients are coptis root, goat bone, cucumber seed, processed aconite, zedoaria, earthworm, wormwood, frankincense, myrrh and liquorice. Coptis root can clear away heat, dry dampness and purge fire, goat bone can nourish the kidney, strengthen tendons and bones, and stop bleeding; cucumber seed can nourish calcium and strengthen bones, processed aconite can dispel wind and dampness, warm the meridians and relieve pain, zedoaria can promote qi and break blood, eliminate accumulation and relieve pain; earthworm can break blood and eliminate symptoms, remove blood stasis and dredge the meridians; wormwood tastes pungent and slightly bitter, is slightly warm in nature, and enters the heart, liver and lung meridians, and can be used to treat bruises and swelling; frankincense has a pungent and fragrant aroma, and can warm and dredge the meridians, disperse blood stasis, promote blood circulation and stretch tendons, remove blood stasis and relieve pain , can dissipate stagnation and reduce swelling; myrrh is bitter, pungent and dispersing, with a mild nature, and is good at dispersing qi stagnation, promoting blood circulation and removing blood stasis, and relieving pain; licorice can invigorate qi, replenish the middle, detoxify, and relieve pain; the various drugs in this traditional Chinese medicine composition are used together to achieve the effects of removing blood stasis and relieving pain, reducing swelling and unblocking meridians, and strengthening tendons and bones. It can effectively treat low back pain caused by intervertebral disc lesions, low back pain caused by lumbar facet arthritis, and low back pain caused by different degrees of degenerative changes of the intervertebral disc, improve the patient's physical condition, and is safe and non-toxic, with good application prospects. DETAILED DESCRIPTION

[0026] The endpoints and any values ​​of the ranges disclosed in this article are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of each range, the endpoint values ​​of each range and the individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed in this article.

[0027] In a first aspect, the present invention provides a traditional Chinese medicine composition for relieving low back pain, wherein the traditional Chinese medicine composition contains rhubarb, pinellia, gardenia, coptis, goat bone, cucumber seed, prepared aconite, zedoaria, earthworm, artemisia selengensis, frankincense, myrrh and liquorice.

[0028] Pharmacological analysis of the raw materials used in the present invention:

[0029] Rhubarb: The medicinal part is the root and rhizome of Rheum palmatum, Rheum officinale or Rheum medicinalum, which belongs to the Polygonaceae family. It has the effects of purging accumulation, clearing away heat and purging fire, cooling blood and detoxifying, and removing blood stasis and dredging menstruation.

[0030] Pinellia: The medicinal part is the tuber of a perennial herb of the genus Pinellia in the Araceae family. It has the effects of drying dampness and resolving phlegm, relieving adverse effects and stopping vomiting, and eliminating lumps and dispersing nodules.

[0031] Gardenia: The medicinal part is the dried mature fruit of the Rubiaceae plant Gardenia, which has the effects of purging fire and relieving restlessness, clearing heat and removing dampness, cooling blood and detoxifying, reducing swelling and relieving pain.

[0032] Coptis chinensis: The medicinal part is the dried rhizome of Coptis chinensis, Coptis chinensis triangular leaf or Coptis chinensis of the Ranunculaceae family, which has the effects of clearing away heat and dampness, purging fire and detoxifying.

[0033] Goat bones: The medicinal part is goat bones, which have the effects of nourishing the kidneys, strengthening tendons and bones, and stopping bleeding.

[0034] Cucumber seeds: The medicinal part is the seeds of the cucumber plant of the Cucurbitaceae family. Cucumber is also called green melon. It has the effects of dispelling wind, eliminating phlegm, relieving cough and strengthening bones.

[0035] Processed Aconitum carmichaelii: The medicinal part is the dried rhizome of the Ranunculaceae plant Aconitum kusnezoffii, which has the effects of dispelling wind and dampness, warming the meridians and relieving pain.

[0036] Curcuma: The rhizomes of Curcuma, Curcuma and Curcuma zedoaria, which belong to the ginger family, have the effects of promoting qi and removing blood, eliminating accumulation and relieving pain.

[0037] Earthworm: Earthworm is an insect of the genus Geochelone or the genus Geochelone of the family Geochelone of the order Blattodea. It is also known as Geochelone, Earth Turtle, Earth Yuan, etc. The medicinal part is the dried body of the animal, which has the effects of breaking blood, removing blood stasis, and repairing tendons and bones.

[0038] Artemisia striata: the whole herb of Artemisia striata, also known as Artemisia striata and Artemisia horn. The whole herb is used as medicine, which has the effects of dispelling wind and relieving exterior symptoms, strengthening the stomach and eliminating accumulation, and promoting blood circulation and removing blood stasis.

[0039] Frankincense: It is the resin exuded from the bark of the frankincense tree and the same genus plants of the olive family. It is also known as nipple incense and Tianze incense. The medicinal part is the resin of the plant. This product is in the form of long oval milky drops, round particles or irregular blocks of varying sizes. The largest one is up to 2cm (frankincense beads) or 5cm (original frankincense). The surface is yellow-white, translucent, covered with yellow-white powder, and the color deepens with long storage. It is brittle and softens when heated. The broken surface has a glassy or waxy luster. It has a unique aroma and a slightly bitter taste. It has the effects of promoting blood circulation, promoting qi, relieving pain, and reducing swelling and promoting tissue regeneration.

[0040] Myrrh: It is the dried resin of the olive family plant, the myrrh tree or the hardy tree. It is divided into natural myrrh and colloid myrrh, also known as powder medicine and bright myrrh. The medicinal part is the dried resin, which has the effects of dispersing blood stasis, relieving pain, reducing swelling and promoting tissue regeneration.

[0041] Licorice: The medicinal part is the dried roots and rhizomes of the legume plants licorice, licorice inflated fruit or licorice glabra. It has the effects of invigorating qi and tonifying the middle, removing phlegm and relieving cough, detoxifying, relieving acute pain and alleviating medicinal properties.

[0042] The Chinese medicine components used in the present invention can all be obtained through commercial purchase.

[0043] The Chinese medicine compatibility of the present invention is unique and reasonable. The combination of the above raw materials can make the medicines work together to achieve the effects of relieving pain, reducing swelling and unblocking meridians, and strengthening tendons and bones. After repeated research and optimization, the Chinese medicine composition provided by the present invention has achieved good results in clinical practice. It can effectively treat low back pain caused by intervertebral disc lesions, low back pain caused by lumbar facet arthritis, and low back pain caused by different degrees of degeneration of the intervertebral disc, improve the patient's physical condition, and is safe and non-toxic, with good application prospects.

[0044] According to the present invention, preferably, relative to 100 parts by weight of rhubarb, the content of the pinellia tuber is 30-50 parts by weight, the content of the gardenia is 70-90 parts by weight, the content of the coptis root is 10-30 parts by weight, the content of the goat bone is 10-30 parts by weight, the content of the cucumber seed is 10-30 parts by weight, the content of the processed aconite is 10-20 parts by weight, the content of the zedoaria is 10-20 parts by weight, the content of the earthworm is 10-20 parts by weight, the content of the artemisia striata is 90-120 parts by weight, the content of the frankincense is 30-50 parts by weight, the content of the myrrh is 30-50 parts by weight, and the content of the liquorice is 10-20 parts by weight. The inventor has found that the combination and dosage ratio of the above raw materials can make the various drugs used together to play the effects of relieving pain, reducing swelling and unblocking meridians, and strengthening tendons and bones.

[0045] In the present invention, the above-mentioned Chinese medicinal raw materials can be obtained through commercial purchase.

[0046] In a second aspect, the present invention provides a method for preparing a Chinese medicine preparation for relieving low back pain, the method comprising the following steps:

[0047] (1) mixing a mixture A of rhubarb, pinellia tuber, gardenia, coptis root, goat bone and cucumber seed with a solvent containing a monohydric alcohol, performing at least one alcohol extraction, and collecting an alcohol extract;

[0048] Mixing a mixture B of processed Aconitum kusnezoffii, Curcuma zedoaria, Eupolyphaga sinensis, Artemisia selengensis, frankincense, myrrh and liquorice with water, performing at least one decoction and solid-liquid separation to obtain a water extract;

[0049] (2) Mixing the alcohol extract and the water extract obtained in step (1).

[0050] The preparation method of the traditional Chinese medicine preparation provided by the present invention has the advantages of simple and safe operation in the whole preparation process, and the prepared medicine is convenient for patients to use, and the synergistic effect between the drugs is maximized. The medicine can effectively treat low back pain caused by intervertebral disc lesions, low back pain caused by lumbar facet arthritis, and low back pain caused by different degrees of degeneration of the intervertebral disc, and improve the physical condition of the patient.

[0051] There is no special limitation on the mixing process in the present invention. The Chinese medicine components can be crushed before mixing. There is no special limitation on the method and equipment for decoction and solid-liquid separation. The crushing can be carried out by a crusher, a grinder or other methods, and the solid-liquid separation can be carried out by filter pressing, suction filtration or other methods.

[0052] The Chinese medicine preparation provided by the present invention can be prepared into any commonly used preparation, including sprays, plasters, tinctures, liniments, external water preparations, film coatings, tinctures or ointments; pharmaceutically acceptable excipients and / or drying can also be added during the preparation process to obtain the desired preparation. For example, using the above preparation method, the alcohol extract and the water extract can be directly used as a spray after mixing, or can be used as a plaster after appropriate concentration, or combined with other excipients to make a plaster.

[0053] According to the present invention, preferably, relative to 100 parts by weight of rhubarb, the content of the pinellia tuber is 30-50 parts by weight, the content of the gardenia is 70-90 parts by weight, the content of the coptis root is 10-30 parts by weight, the content of the goat bone is 10-30 parts by weight, the content of the cucumber seed is 10-30 parts by weight, the content of the processed aconite is 10-20 parts by weight, the content of the zedoaria is 10-20 parts by weight, the content of the earthworm is 10-20 parts by weight, the content of the artemisia striata is 90-120 parts by weight, the content of the frankincense is 30-50 parts by weight, the content of the myrrh is 30-50 parts by weight, and the content of the liquorice is 10-20 parts by weight. The inventor has found that the combination and dosage ratio of the above raw materials can make the drugs used together, and the prepared Chinese medicine preparation for relieving low back pain has the effects of improving pain relief, detumescence and collateral dredgement, and strengthening tendons and bones.

[0054] According to the present invention, preferably, the alcohol extraction step in step (1) comprises: mixing and soaking the mixture A with the solvent containing a monohydric alcohol. The mixed soaking process in step (1) can be that rhubarb, pinellia, gardenia, coptis, goat bone and cucumber seeds are mixed and soaked with a solvent containing a monohydric alcohol respectively and then the mixed solution is mixed together, or rhubarb, pinellia, gardenia, coptis, goat bone and cucumber seeds are mixed and then soaked with a solvent containing a monohydric alcohol. Further preferably, the rhubarb, pinellia, gardenia, coptis, goat bone and cucumber seeds in the mixture A can be crushed and mixed, and there is no strict requirement for the order of crushing, and rhubarb, pinellia, gardenia, coptis, goat bone and cucumber seeds can be mixed together and crushed, or they can be crushed separately and mixed. The inventors have found that the effective ingredients in the Chinese medicine components after mixing and soaking with a solvent containing a monohydric alcohol can be better extracted and retained, thereby improving the effects of relieving pain, reducing swelling and unblocking meridians, and strengthening tendons and bones.

[0055] According to the present invention, it is further preferred that the monohydric alcohol is selected from at least one of C1-C3 monohydric alcohols, and ethanol is further preferred. The inventors have found that when ethanol is used for alcohol extraction, the extraction efficiency of the effective ingredients in each Chinese medicine raw material is higher, further improving the effects of relieving pain, reducing swelling, unblocking meridians, and strengthening tendons and bones.

[0056] According to the present invention, preferably, the solvent containing monohydric alcohol is a mixture of monohydric alcohol and water, and in the mixture of monohydric alcohol and water, the volume percentage of the monohydric alcohol is 20-95%, specifically 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, or any value between any two of the above values. The inventors have found that under this preferred specific implementation, the scheme of the present invention has the effect of further improving the extraction efficiency of the effective ingredients in each Chinese medicine raw material, thereby improving the therapeutic effect of the Chinese medicine preparation in relieving low back pain.

[0057] According to the present invention, further preferably, the conditions of the alcohol extraction at least include: a temperature of 25-45°C, specifically 25°C, 30°C, 35°C, 40°C, 45°C, or any value between any two of the above values; a time of 1-2h, specifically 1h, 1.5h, 2h, or any value between any two of the above values. The inventors found that under this preferred specific implementation, the scheme of the present invention has the effect of further improving the extraction efficiency of the effective ingredients in each Chinese medicine raw material, and further improving the therapeutic effect of the Chinese medicine preparation in relieving low back pain.

[0058] According to the present invention, further preferably, the amount of the monohydric alcohol used is 1-5L relative to 1kg of the mixture A, specifically 1L, 2L, 3L, 4L, 5L, or any value between any two of the above values. The inventors have found that under this preferred specific implementation, the scheme of the present invention has the effect of further improving the extraction efficiency of the effective ingredients in each Chinese medicine raw material, thereby improving the therapeutic effect of the Chinese medicine preparation in relieving low back pain.

[0059] According to the present invention, preferably, the method further comprises: mixing and soaking the mixture B with water before the decoction. The order of the mixing is not strictly limited, and the mixture B and water may be mixed, or the processed Aconitum, Curcuma, Eupolyphaga, Artemisia selengensis, Frankincense, Myrrh and Licorice in the mixture B may be mixed with water separately and then mixed. The inventors have found that under this preferred specific embodiment, the scheme of the present invention has the effect of further improving the extraction efficiency of the effective ingredients in each Chinese medicine raw material, thereby further improving the therapeutic effect of the Chinese medicine preparation in relieving low back pain.

[0060] According to the present invention, further preferably, the soaking time is 30-60 minutes, specifically 30 minutes, 40 minutes, 50 minutes, 60 minutes, or any value between any two of the above values. The inventors found that under this preferred specific implementation, the scheme of the present invention has the effect of further improving the extraction efficiency of the effective ingredients in each Chinese medicine raw material, thereby improving the therapeutic effect of the Chinese medicine preparation in relieving low back pain.

[0061] According to the present invention, further preferably, the decoction conditions include: a temperature of 80-100°C, specifically 80°C, 90°C, 100°C, or any value between any two of the above values; a time of 15-30min, specifically 15min, 20min, 25min, 30min, or any value between any two of the above values. The inventors have found that under this preferred specific implementation, the scheme of the present invention has the effect of further improving the extraction efficiency of the effective ingredients in each Chinese medicine raw material, thereby further improving the therapeutic effect of the Chinese medicine preparation in relieving low back pain.

[0062] According to the present invention, further preferably, the amount of the solvent containing the monohydric alcohol is 1-5L relative to 1kg of the mixture B, specifically 1L, 2L, 3L, 4L, 5L, or any value between any two of the above values. The inventors have found that under this preferred specific implementation, the scheme of the present invention has the effect of further improving the extraction efficiency of the effective ingredients in each Chinese medicine raw material, thereby further improving the therapeutic effect of the Chinese medicine preparation in relieving low back pain.

[0063] According to the present invention, preferably, the step (2) further comprises: before the mixing, the alcohol extract and the water extract are respectively concentrated under reduced pressure. The degree of reduced pressure concentration can be selected according to the conditions of the preparation, and some solvents can be retained, or all solvents can be removed. Preferably, after reduced pressure concentration, freeze drying can be performed to further purify the active ingredients, thereby further improving the therapeutic effect of the traditional Chinese medicine preparation in relieving low back pain.

[0064] As a preferred embodiment of the present invention, before the mixing, the alcohol extract and the water extract are respectively concentrated under reduced pressure to a density of 1.1-1.3 g / mL to obtain a paste extract. 1-3 g of the paste extract is directly applied or made into a plaster and applied to the affected area, which has a quick effect, is easy to use, and improves the therapeutic effect of relieving low back pain.

[0065] In a third aspect, the present invention provides a Chinese medicine preparation prepared according to the preparation method described in the second aspect. The Chinese medicine preparation provided by the present invention can be prepared into any commonly used preparation, including sprays, plasters, tinctures, liniments, external water preparations, film coatings, tinctures or ointments; pharmaceutically acceptable excipients can also be added during the preparation process to obtain the required preparation. For example, using the above preparation method, the alcohol extract and the water extract can be directly used as a spray after mixing, or can be used as a plaster after appropriate concentration, or combined with other excipients to make a plaster.

[0066] The fourth aspect of the present invention provides a use of the Chinese medicine composition described in the first aspect or the Chinese medicine preparation prepared according to the preparation method described in the second aspect in a medicine for relieving low back pain.

[0067] In the present invention, the medicine for relieving lumbago can directly adopt the Chinese medicine preparation provided by the present invention, or the above-mentioned Chinese medicine preparation can be further supplemented with conventional pharmaceutical excipients.

[0068] The present invention will be described in detail below through examples.

[0069] In the following examples, rhubarb, pinellia, gardenia, coptis, goat bone, cucumber seed, prepared aconite, zedoaria, earthworm, artemisia selengensis, frankincense, myrrh and liquorice were all purchased from offline drug agents.

[0070] Example 1

[0071] (1) A mixture A of 1000 g of rhubarb, 450 g of pinellia, 850 g of gardenia, 250 g of coptis root, 150 g of goat bone and 250 g of cucumber seed was crushed, mixed with 9.18 L of 95% ethanol by volume, and soaked for 30 min, then heated at 45° C. for 1 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue was mixed with 4 L of 95% ethanol by volume, soaked for 30 min, heated at 40° C. for 2 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and the two filtrates were combined to obtain an alcohol extract;

[0072] A mixture B of 150 g of processed Aconitum, 150 g of Curcuma, 150 g of Eupolyphaga sinensis, 1050 g of Artemisia selengensis, 450 g of Frankincense, 450 g of Myrrha and 150 g of Licorice is mixed with 1.2 L of water and soaked for 60 min, boiled for 30 min at 100° C., and separated into a solid and a liquid to obtain a water extract; filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue is mixed with 1.2 L of water again, boiled for 30 min at 100° C., filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and the two filtrates are combined to obtain a water extract;

[0073] (2) The alcohol extract and the water extract obtained in step (1) are respectively concentrated under reduced pressure and then mixed evenly to obtain a paste with a density of 1.2 g / mL.

[0074] Example 2

[0075] (1) A mixture A of 1000 g of rhubarb, 400 g of pinellia, 800 g of gardenia, 200 g of coptis root, 200 g of goat bone and 200 g of cucumber seed was crushed, mixed with 13.62 L of 95% ethanol by volume, and soaked for 30 min, then heated at 40° C. for 2 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue was mixed with 6 L of 95% ethanol by volume, soaked for 30 min, heated at 40° C. for 1 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and the two filtrates were combined to obtain an alcohol extract;

[0076] A mixture B of 120 g of processed Aconitum, 120 g of Curcuma, 120 g of Eupolyphaga sinensis, 1000 g of Artemisia argyi, 400 g of frankincense, 400 g of Myrrha and 120 g of Licorice was mixed with 1.44 L of water and soaked for 60 min, boiled for 20 min at 90° C., and separated into a solid and liquid to obtain a water extract; filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue was mixed with 1.44 L of water again, boiled for 15 min at 100° C., filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and the two filtrates were combined to obtain a water extract;

[0077] (2) The alcohol extract and the water extract obtained in step (1) are concentrated under reduced pressure and then mixed evenly to obtain a paste with a density of 1.2 g / mL.

[0078] Example 3

[0079] (1) A mixture A of 1000 g of rhubarb, 350 g of pinellia, 750 g of gardenia, 150 g of coptis root, 250 g of goat bone and 150 g of cucumber seed was crushed, mixed with 4.45 L of 95% ethanol by volume, and soaked for 60 min, then heated at 30° C. for 2 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue was mixed with 4 L of 95% ethanol by volume, and soaked for 30 min, then heated at 40° C. for 2 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and the two filtrates were combined to obtain an alcohol extract;

[0080] Mixture B of 100 g of processed Aconitum, 100 g of Curcuma, 100 g of Eupolyphaga sinensis, 950 g of Artemisia scoparia, 350 g of frankincense, 350 g of Myrrha and 100 g of Licorice with 0.4 L of water and soak for 30 min, decoct for 30 min at 80° C., separate solid from liquid to obtain a water extract; filter through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; mix the first medicinal residue with 0.4 L of water again, decoct for 30 min at 100° C., filter through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, combine the two filtrates to obtain a water extract;

[0081] (2) The alcohol extract and the water extract obtained in step (1) are concentrated under reduced pressure and then mixed evenly to obtain a paste with a density of 1.2 g / mL.

[0082] Example 4

[0083] (1) A mixture A of 1000 g of rhubarb, 500 g of pinellia, 900 g of gardenia, 300 g of coptis root, 300 g of goat bone and 300 g of cucumber seed was crushed, mixed with 25.75 L of 95% ethanol by volume, and soaked for 30 min, then heated at 45° C. for 1 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue was mixed with 12 L of 95% ethanol by volume, soaked for 30 min, heated at 40° C. for 2 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and the two filtrates were combined to obtain an alcohol extract;

[0084] Mix 200g of processed Radix Aconiti Kusnezoffii, 200g of Rhizoma Curcumae, 200g of Eupolyphaga Seu Steleophaga, 1200g of Artemisia selengensis, 500g of Olibanum, 500g of Myrrha and 200g of Liquorice with 4L of water and soak for 60min, decoct for 30min at 100°C, separate solid from liquid to obtain a water extract; filter through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; mix the first medicinal residue with 2L of water again, decoct for 30min at 100°C, filter through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, combine the two filtrates to obtain a water extract;

[0085] (2) The alcohol extract and the water extract obtained in step (1) were concentrated under reduced pressure and then mixed evenly to obtain a paste with a density of 1.3 g / mL.

[0086] Example 5

[0087] (1) A mixture A of 1000 g of rhubarb, 300 g of pinellia, 700 g of gardenia, 100 g of coptis root, 100 g of goat bone and 100 g of cucumber seed was crushed, mixed with 16.6 L of 95% ethanol by volume, and soaked for 30 min, then heated at 45° C. for 1 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue was mixed with 4 L of 95% ethanol by volume, soaked for 30 min, heated at 40° C. for 2 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and the two filtrates were combined to obtain an alcohol extract;

[0088] Mixture B of 100 g of processed Radix Aconiti Kusnezoffii, 100 g of Curcuma Rhizoma, 100 g of Eupolyphaga sinensis, 900 g of Artemisia scoparia, 300 g of frankincense, 300 g of myrrh and 100 g of liquorice with 1.6 L of water and soak for 60 min, decoct for 30 min at 100° C., separate solid from liquid to obtain a water extract; filter through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; mix the first medicinal residue with 1.2 L of water again, decoct for 30 min at 100° C., filter through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and combine the two filtrates to obtain a water extract;

[0089] (2) The alcohol extract and the water extract obtained in step (1) are concentrated under reduced pressure and then mixed evenly to obtain a paste with a density of 1.1 g / mL.

[0090] Example 6

[0091] (1) A mixture A of 1000 g of rhubarb, 850 g of pinellia, 850 g of gardenia, 850 g of coptis, 1000 g of goat bones and 850 g of cucumber seeds was crushed and mixed with 10.8 L of 95% ethanol by volume, and then soaked for 30 min. The mixture was heated at 45° C. for 1 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue was mixed with 4 L of 95% ethanol by volume, and then soaked for 30 min. The mixture was heated at 40° C. for 2 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue. The two filtrates were combined to obtain an alcohol extract;

[0092] Mixture B of 250g of processed Aconitum, 250g of Curcuma, 250g of Eupolyphaga sinensis, 500g of Artemisia argyi, 600g of frankincense, 600g of Myrrha and 250g of Licorice with 2L of water and soak for 60min, decoct for 30min at 100°C, separate solid from liquid to obtain a water extract; filter through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; mix the first medicinal residue with 2L of water again, decoct for 30min at 100°C, filter through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, combine the two filtrates to obtain a water extract;

[0093] (2) The alcohol extract and the water extract obtained in step (1) were concentrated under reduced pressure and then mixed evenly to obtain a paste with a density of 1.3 g / mL.

[0094] Example 7

[0095] (1) A mixture A of 1000 g of rhubarb, 500 g of pinellia, 500 g of gardenia, 500 g of coptis, 600 g of goat bones and 500 g of cucumber seeds was crushed, mixed with 7.2 L of 95% ethanol by volume, and soaked for 30 min, then heated at 45° C. for 1 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue was mixed with 4 L of 95% ethanol by volume, soaked for 30 min, heated at 40° C. for 2 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and the two filtrates were combined to obtain an alcohol extract;

[0096] A mixture B of 80 g of processed Aconitum, 80 g of Curcuma, 80 g of Eupolyphaga sinensis, 80 g of Artemisia selengensis, 100 g of frankincense, 100 g of Myrrha and 80 g of Licorice was mixed with 0.64 L of water and soaked for 60 min, boiled at 100° C. for 30 min, and separated into solid and liquid to obtain a water extract; filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue was mixed with 0.64 L of water again, boiled at 100° C. for 30 min, filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and the two filtrates were combined to obtain a water extract;

[0097] (2) The alcohol extract and the water extract obtained in step (1) are concentrated under reduced pressure and then mixed evenly to obtain a paste with a density of 1.2 g / mL.

[0098] Example 8

[0099] (1) a mixture A of 1000 g of rhubarb, 4500 g of pinellia, 8500 g of gardenia, 250 g of coptis root, 150 g of goat bone and 250 g of cucumber seed was crushed, mixed with 9.18 L of water and soaked for 60 min, boiled at 100° C. for 30 min, and separated into a water extract by solid-liquid separation; filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue was mixed with 4 L of water, boiled at 100° C. for 30 min, filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and the two filtrates were combined to obtain a water extract;

[0100] A mixture B of 150 g of processed Aconitum, 150 g of Curcuma, 150 g of Eupolyphaga sinensis, 1050 g of Artemisia scoparia, 450 g of frankincense, 450 g of Myrrha and 150 g of Licorice was mixed with 1.2 L of 95% ethanol by volume and soaked for 30 min, heated at 45° C. for 1 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a first filtrate and a first medicinal residue; the first medicinal residue was mixed with 1.2 L of 95% ethanol by volume and soaked for 30 min, heated at 40° C. for 2 h for alcohol extraction, and filtered through a 100-mesh sieve to obtain a second filtrate and a second medicinal residue, and the two filtrates were combined to obtain an alcohol extract;

[0101] (2) The alcohol extract and the water extract obtained in step (1) are concentrated under reduced pressure and then mixed evenly to obtain a paste with a density of 1.2 g / mL.

[0102] Comparative Example 1

[0103] The same method as in Example 1 was used, except that 150 g of Herba Scutellariae was used to replace 150 g of goat bone, to obtain a paste with a density of 1.2 g / mL.

[0104] Comparative Example 2

[0105] The same method as in Example 1 was used, except that 250 g of lettuce seeds were used instead of 250 g of cucumber seeds to obtain a paste with a density of 1.2 g / mL.

[0106] Comparative Example 3

[0107] The same method as in Example 1 was used, except that 150 g of Salvia miltiorrhiza was used to replace 150 g of Curcuma zedoaria, to obtain a paste with a density of 1.2 g / mL.

[0108] Comparative Example 4

[0109] The same method as in Example 1 was used, except that 1050 g of Clematis chinensis was used to replace 1050 g of Artemisia scoparia, to obtain a paste with a density of 1.1 g / mL.

[0110] Comparative Example 5

[0111] The same method as in Example 1 was used, except that 450 g of Notopterygium incisum was used to replace 450 g of Olibanum, to obtain an ointment with a density of 1.2 g / mL.

[0112] Comparative Example 6

[0113] The same method as in Example 1 was adopted, except that Gardenia jasminoides was not added to obtain a paste having a density of 1.3 g / mL.

[0114] Comparative Example 7

[0115] The same method as in Example 1 was used, except that goat bones and cucumber seeds were not added to obtain a paste with a density of 1.2 g / mL.

[0116] Test Example 1

[0117] Chinese herbal plaster improves back pain in rats

[0118] Female SD rats (weight 180-220g, age 2-4 months) were used as experimental subjects. An in vitro spring compression device was installed on the 8th and 10th coccygeal vertebrae of the rats to apply additional axial stress to the intervertebral discs of the two coccygeal vertebrae. This was used to simulate the morphological and biochemical changes of the human lumbar spine under different loads and load durations, and to construct a rat model of low back pain caused by intervertebral disc pathology.

[0119] Female SD rats (weight 180-220 g, age 2-4 months) were used as experimental subjects, and 3 μL of Freund's adjuvant was randomly injected into one side of the L5-L6 facet joint of the rats to construct an animal model of low back pain caused by lumbar facet arthritis.

[0120] Female SD rats (weight 180-220g, age 2-4 months) were used as experimental subjects. Micro-silicone balls were used to compress the L5 and C5 nerve roots of rats to establish a "chronic nerve root injury model". By removing the silicone balls, a "nerve root injury decompression model" was established. The rat animal model of low back pain caused by different degrees of intervertebral disc degeneration was constructed.

[0121] 1 g of each of the pastes obtained in Examples 1 to 8 and Comparative Examples 1 to 7 was applied on a non-woven adhesive tape to form a circle with a radius of 5 cm to prepare a plaster.

[0122] The rats were divided into three groups according to the above rat animal model, and each large group was randomly divided into a model control group and an intervention group, wherein the intervention group had 11 subgroups, corresponding to Examples 1 to 8 and Comparative Examples 1 to 7, respectively, with 8 rats in each group; the intervention group applied the plasters prepared in the corresponding Examples or Comparative Examples on the affected parts for 12 hours, replaced them with new plasters after an interval of 1-2 hours and continued to apply them for 12 hours, and continued to apply them after an interval of 1-2 hours, and applied 14 plasters continuously; after the intervention, the changes in the rats' animal behavior (including: open field test, forced swimming test) were used to analyze the changes in the rats' low back pain, and the statistical differences of the groups were compared.

[0123] Among them, the statistical results of behavioral changes in rats with low back pain model caused by intervertebral disc lesions are shown in Table 1; the statistical results of behavioral changes in rats with low back pain animal model caused by lumbar facet arthritis are shown in Table 2; the statistical results of behavioral changes in rats with low back pain animal model caused by different degrees of intervertebral disc degeneration are shown in Table 3.

[0124] Open-field test: The open-field test device is made of opaque material, with a size of 90cm*90cm*45cm, and is divided into 25 equilateral squares. The rat is placed in the central square, and the number of horizontal movements (the number of crossing the peripheral squares and the number of crossing the central squares) and vertical movements of the rat are observed within 3 minutes. A horizontal movement is recorded only when all four paws enter a square, and a vertical movement is recorded only when both front paws are in the air or cling to the wall.

[0125] Forced swimming test: Rats were placed in a cylindrical water tank with a height of 50 cm and a diameter of 20 cm. The water depth was about 40 cm. Rats were randomly selected and two were observed each time. The double-blind method was used for detection. The adaptation time was 60 seconds after the start of the experiment. After the adaptation was completed, the immobility time of the rats within 5 minutes was recorded.

[0126] Table 1

[0127]

[0128]

[0129] Table 2

[0130]

[0131] Table 3

[0132]

[0133] It can be seen from the results in Tables 1 to 3 that the Chinese medicine plaster products prepared by Examples 1 to 8 of the present invention can increase the vertical movement time and horizontal movement time of rats with low back pain model caused by intervertebral disc lesions, rats with low back pain animal model caused by lumbar facet arthritis, and rats with low back pain animal model caused by different degrees of intervertebral disc degeneration, and reduce the immobility time of forced swimming, indicating that the Chinese medicine composition provided by the present invention can effectively improve the low back pain in rats.

[0134] 1 g of the ointment obtained in Example 1 of the present invention was applied on a non-woven adhesive tape to form a circle with a radius of 5 cm to prepare a typical case of clinical application of the ointment:

[0135] Case 1

[0136] Patient Li, female, 33 years old, had lumbago without obvious cause 3 months ago. The initial pain was mild, intermittent and dull, and was not taken seriously. Later, the pain gradually increased, and was persistent, especially after fatigue, and rest could be slightly relieved. The pain was mainly located in the lumbar sacral region, without radiating pain in the lower limbs, and without incontinence. Diagnosed as: lumbar muscle strain, continuous application of the plaster of the present invention, one patch per day, each time for 12 hours, return visit after 3 weeks, lumbago symptoms alleviated, continued application after 4 weeks, symptoms completely disappeared, and no recurrence was observed in follow-up for half a year.

[0137] Case 2

[0138] The patient, Zhao, 55 years old, suddenly developed low back pain symptoms while moving heavy objects about two months ago. The initial pain felt like soreness, and the pain was mild. It was only noticed during specific movements or postures, such as bending over for a long time, twisting the waist quickly, etc. At this time, it was intermittent, and each pain lasted about two hours. The pain was mainly concentrated beside the 3-4 lumbar spinous processes, the right psoas major muscle, and the middle of the lumbar sacral region. At first, the pain was relieved quickly after rest, but as time went on, the pain gradually worsened. At present, the pain is persistent, and the pain intensifies when bending over to move things, standing for a long time, and getting up after sitting for a long time, to the extent that it is unbearable and affects normal activities. During the process of worsening pain, there was no radiating pain in the lower limbs, but when sitting for a long time, the patient felt other abnormal sensations such as tightness and swelling in the waist. The pain has developed to this day and has had a significant impact on the patient's daily life. When walking, the patient needs to walk slowly, stop and go, etc. due to pain, and it is unbearable to walk more than 50 meters. When bending over, it can only bend to 60°C, which is severely limited and cannot be performed normally, such as tying shoelaces, picking up things, etc. When sitting, the waist is unbearably painful for more than 30 minutes, and it is necessary to frequently adjust the posture or get up to move. Since the onset of the disease, the patient has not had other accompanying symptoms such as fever, chills, nausea, vomiting, numbness of lower limbs, incontinence, etc. Continuously apply the plaster of the present invention, one patch a day, each time for 12 hours, and return to the clinic after 5 weeks. The symptoms of low back pain are alleviated, and the symptoms disappear completely after continuing to apply for 5 weeks. Follow-up for half a year has no recurrence.

[0139] Case 3

[0140] Patient Zhao, 38 years old, construction worker. Sudden back pain after carrying heavy objects at the construction site 2 weeks ago. The pain is severe, persistent, and like a knife cut. Mainly located in the middle of the lower back, and accompanied by pain radiating to the buttocks. The pain is significantly aggravated after bending over, exerting force and standing for a long time, and the pain can be slightly relieved when lying flat. Over time, the pain causes the patient to move more and more difficultly, and needs to move slowly when walking, and cannot maintain a standing or sitting position for a long time, which seriously affects sleep and makes it difficult to turn over. Diagnosed as: lumbar disc herniation (lumbar 4-5): related to heavy physical labor and previous lumbar injury. Absolute bed rest for 3 weeks, the bed surface needs to be harder. Mannitol dehydration and dexamethasone are given to reduce nerve root edema. Continuously apply the plaster of the present invention, one patch a day, 12 hours each time, and return to the clinic after 4 weeks. The symptoms of low back pain are alleviated, and the symptoms disappear completely after continuing to apply for 6 weeks, and there is no recurrence in the follow-up for half a year.

[0141] Case 4

[0142] Patient Sun, female, 52 years old, housewife. 3 months ago, there was no obvious cause for lumbago, which was intermittent soreness at first, and the degree was relatively mild. The pain was located in the bilateral waist, slightly heavier when getting up in the morning, and relieved after activity. In the past month, the pain gradually increased and became persistent. The pain intensified after sitting, standing or bending over to do housework for a long time, and the relief was not obvious after rest. Conscious waist stiffness, occasionally accompanied by slight tingling, without lower limb radiating pain, numbness and other situations. At present, daily housework such as mopping the floor, drying clothes, etc. have been affected, and walking time is slightly longer and also needs to rest because of lumbago discomfort. Diagnosed as: osteoporotic lumbago: caused by vertebral microfracture, muscle strain, etc. due to osteoporosis. Continuously apply the plaster of the present invention, one patch a day, 12 hours each time, and return to the clinic after 4 weeks. The symptoms of lumbago are alleviated, and the symptoms disappear completely after continuing to apply for 5 weeks, and there is no recurrence in follow-up for half a year.

[0143] Case 5

[0144] Patient Zhang, 40 years old, driver. Due to long-term driving, he developed low back pain 3 weeks ago. At first, it was intermittent dull pain, concentrated in the lower back. The pain worsened after sitting for a long time, and rest could relieve it. Later, the pain worsened and became persistent, accompanied by stiff waist. It affected driving and made it difficult to get out of the car. Physical examination: the physiological curvature of the lumbar spine became straight, and there was tenderness in the lower back. Diagnosed as lumbar muscle strain. Continuously apply the plaster of the present invention, one patch a day, each time for 12 hours, and re-examine after 2 weeks. The low back pain symptoms were alleviated. After continuing to apply for 3 weeks, the symptoms completely disappeared, and no recurrence was found in the follow-up for half a year.

[0145] Case 6

[0146] Patient Li, 30 years old, office worker. One month ago, there was no cause of low back pain, soreness, intermittent. Located in the middle of the waist, it is aggravated by bending over for a long time, and there are no lower limb symptoms. The lumbar spine is slightly limited in activity and tenderness, which is lumbar facet joint disorder. The plaster of the present invention is applied continuously, one patch a day, each time for 12 hours. After 3 weeks of follow-up, the low back pain symptoms are alleviated. After continuing to apply for 4 weeks, the symptoms completely disappeared. No recurrence was found in the follow-up for half a year.

[0147] Case 7

[0148] Patient Zhao, 68 years old, retired. He had lumbago in the morning for 3 months, which was mild at first and then aggravated. The pain was persistent dull pain, located in the whole waist. He had a history of osteoporosis. Examination revealed extensive tenderness in the lumbar spine. Diagnosis of osteoporotic lumbago. The plaster of the present invention was applied continuously, once a day, for 12 hours each time. After 5 weeks of follow-up, the lumbago symptoms were alleviated. After continuing to apply for 6 weeks, the symptoms completely disappeared, and no recurrence was found in the follow-up for half a year.

[0149] Case 8

[0150] Patient Sun, 48 years old, teacher. Long-term standing teaching, low back pain in the past 2 weeks. Stabbing pain, intermittent, located on both sides of the waist. The pain is aggravated by standing for a long time, and can be relieved by rest. Physical examination: lumbar muscle tension, tenderness, diagnosed with lumbar myofasciitis. Continuously apply the plaster of the present invention, one patch a day, each time for 12 hours, re-examination after 2 weeks, low back pain symptoms are alleviated, and the symptoms completely disappear after continuing to apply for 3 weeks, and no recurrence is found in the follow-up for half a year.

[0151] Case 9

[0152] Patient Zhou, 50 years old, athlete. Sudden back pain 1 week after training, severe pain. In the middle of the waist, limited movement, unable to bend. Has a history of old waist injury. Examination showed local tenderness and muscle spasm. Diagnosis of acute lumbar sprain. Continuously apply the plaster of the present invention, one patch per day, each time for 12 hours, re-examination after 2 weeks, the back pain symptoms are alleviated, and the symptoms completely disappear after continuing to apply for 3 weeks, and no recurrence is found in the follow-up for half a year.

[0153] Case 10

[0154] Zheng, female, 55 years old, accountant. The main reason is "low back pain accompanied by fatigue for more than 1 year, gradually worsening." See a doctor. Usually sitting for a long time at work, low back pain persists, feeling low back fatigue, and reduced endurance for daily activities. There is a history of lumbar degeneration. There is a snapping sound when the lumbar spine moves, mild tenderness at multiple paravertebral sites, slightly weakened muscle strength, no radiating pain in the lower limbs, and a negative straight leg raising test. Diagnosed as lumbar degeneration. Continuously apply the plaster of the present invention, one patch a day, each time for 12 hours, and re-examine after 2 weeks. The symptoms of low back pain are alleviated. After continuing to apply for 5 weeks, the symptoms completely disappear, and no recurrence is observed in the follow-up for half a year.

[0155] The preferred embodiments of the present invention are described in detail above, but the present invention is not limited thereto. Within the technical concept of the present invention, the technical solution of the present invention can be subjected to a variety of simple modifications, including the combination of various technical features in any other suitable manner, and these simple modifications and combinations should also be regarded as the contents disclosed by the present invention and belong to the protection scope of the present invention.

Claims

1. A Chinese medicine composition for relieving low back pain, characterized in that: The traditional Chinese medicine composition contains rhubarb, pinellia tuber, gardenia, coptis root, goat bone, cucumber seed, processed aconite, zedoaria, earthworm, artemisia selengensis, frankincense, myrrh and liquorice.

2. The Chinese medicine composition according to claim 1, characterized in that: Relative to 100 parts by weight of rhubarb, the content of pinellia is 30-50 parts by weight, the content of gardenia is 70-90 parts by weight, the content of coptis chinensis is 10-30 parts by weight, the content of goat bone is 10-30 parts by weight, the content of cucumber seed is 10-30 parts by weight, the content of processed aconite is 10-20 parts by weight, the content of curcuma is 10-20 parts by weight, the content of earthworm is 10-20 parts by weight, the content of artemisia striata is 90-120 parts by weight, the content of frankincense is 30-50 parts by weight, the content of myrrh is 30-50 parts by weight, and the content of liquorice is 10-20 parts by weight.

3. A method for preparing a Chinese medicine preparation for relieving low back pain, characterized in that: The method comprises the following steps: (1) mixing a mixture A of rhubarb, pinellia, gardenia, coptis, goat bone and cucumber seed with a solvent containing a monohydric alcohol, performing alcohol extraction at least once, and collecting an alcohol extract; Mixing a mixture B of processed Aconitum, Curcuma, Eupolyphaga, Artemisia selengensis, Frankincense, Myrrh and Licorice with water, performing at least one decoction, and performing solid-liquid separation to obtain a water extract; (2) Mixing the alcohol extract and the water extract obtained in step (1).

4. The preparation method according to claim 3, characterized in that: Relative to 100 parts by weight of rhubarb, the content of pinellia is 30-50 parts by weight, the content of gardenia is 70-90 parts by weight, the content of coptis chinensis is 10-30 parts by weight, the content of goat bone is 10-30 parts by weight, the content of cucumber seed is 10-30 parts by weight, the content of processed aconite is 10-20 parts by weight, the content of curcuma is 10-20 parts by weight, the content of earthworm is 10-20 parts by weight, the content of artemisia striata is 90-120 parts by weight, the content of frankincense is 30-50 parts by weight, the content of myrrh is 30-50 parts by weight, and the content of liquorice is 10-20 parts by weight.

5. The preparation method according to claim 3 or 4, characterized in that: The alcohol extraction step in step (1) comprises: mixing and soaking the mixture A with the solvent containing the monohydric alcohol; Preferably, the monohydric alcohol is selected from at least one of C1-C3 monohydric alcohols, and more preferably ethanol.

6. The preparation method according to claim 5, characterized in that: The solvent containing monohydric alcohol is a mixture of monohydric alcohol and water, and the volume percentage of the monohydric alcohol in the mixture of monohydric alcohol and water is 20-95%; Preferably, the alcohol extraction conditions include at least: temperature of 25-45°C and time of 1-2h; Preferably, relative to 1 kg of the mixture A, the amount of the monohydric alcohol used is 1-5 L.

7. The preparation method according to claim 3 or 4, characterized in that: The method further comprises: mixing and soaking the mixture B with water before the decocting; Preferably, the soaking time is 30-60 min; Preferably, the decoction conditions include: temperature of 80-100°C and time of 15-30 min; Preferably, the amount of the solvent containing the monohydric alcohol is 1-5 L relative to 1 kg of the mixture B.

8. The preparation method according to claim 3 or 4, characterized in that: The step (2) further comprises: before the mixing, respectively concentrating the alcohol extract and the water extract under reduced pressure.

9. The Chinese medicine preparation obtained according to the preparation method described in any one of claims 3 to 8.

10. Use of the Chinese medicine composition according to any one of claims 1 to 2 or the Chinese medicine preparation prepared according to the preparation method according to any one of claims 3 to 8 in medicines for relieving low back pain.

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