Remodeling active peptide and preparation method thereof

Abstract

The invention relates to the technical field of wrinkle resistance, in particular to a remodeling active peptide composition and a preparation method thereof. The skin care composition is prepared from acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7, palmitoyl hexapeptide-12, sweet orange flower original liquid, a traditional Chinese medicine extract, a cubilose extract, golden camellia original liquid, an antioxidant, a humectant and a solvent according to the mass ratio of (1-3): (3-9): (4-7): (2-8): (2-4): (5-10): (0.5-1.5): (1-4): (1-3): (1-2): (3-15). The composition with an excellent anti-wrinkle effect is prepared by utilizing the coordination effect of the four small peptides with the anti-wrinkle effect and adding some traditional Chinese medicine extracts and plant original liquid, and after being used, the composition can be quickly absorbed by skin and further acts on the cellular level, so that the anti-wrinkle effect is achieved. According to the present invention, the skin care product has effects of skin whitening, skin whitening, skin whitening, skin whitening, skin whitening, skin whitening, collagen synthesis, fibronectin synthesis, glycosaminoglycan synthesis and eusuperficial cell regeneration promotion, skin cell elasticity and vitality recovery, and long-term use of the skin care product can relieve wrinkles and improve skin, and especially can significantly improve static wrinkles caused by skin inactivation such as nasolabial wrinkles, crow's feet and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of anti-wrinkle, and in particular to a remodeling active peptide composition and a preparation method thereof. Background Art

[0002] Peptides refer to a class of compounds whose molecular structure is between amino acids and proteins. They are functional fragments of proteins, giving proteins tens of thousands of physiological functions. They themselves also have strong physiological activity and can play a role in cell metabolism and prevent cell degeneration in the skin. They can also help the skin inhibit melanin, thereby achieving the purpose of beauty and skin care.

[0003] Peptides are divided into polypeptides, oligopeptides and small peptides according to the number of amino acids. Small peptides generally refer to peptides composed of 2-4 amino acids with a molecular weight between 100-180. Because small peptides directly intervene in the metabolism of blood cells, brain and nerve cells, muscle cells, reproductive cells, endocrine cells, and skin cells, and participate in the growth, development, physiological functions, and division and proliferation of cells, they are used in many cosmetics and health products. However, currently, cosmetics basically only contain one type of peptide, and the effect of a single type of peptide on skin remodeling and anti-wrinkle effects is not very satisfactory. Summary of the invention

[0004] The purpose of the present invention is to provide a remodeling active peptide composition and a preparation method thereof, so as to solve the problem in the prior art that a single type of peptide cannot effectively remodel and anti-wrinkle the skin.

[0005] In order to solve the above technical problems, the first technical solution adopted by the present invention is:

[0006] A remodeling active peptide composition, which is composed of acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7, palmitoyl hexapeptide-12, sweet orange flower extract, Chinese medicine extract, bird's nest extract, golden camellia extract, antioxidant, moisturizer, and solvent in a mass ratio of 1-3:3-9:4-7:2-8:2-4:5-10:0.5-1.5:1-4:1-3:1-2:3-15.

[0007] A further technical solution is that the mass ratio of acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7, and palmitoyl hexapeptide-12 is 2:5:6:7.

[0008] A further technical solution is that the moisturizer is a compound of ethylhexylglycerin, butylene glycol, glycerin, 1,2-hexanediol and sodium hyaluronate, and the mass ratio of ethylhexylglycerin, butylene glycol, glycerin, 1,2-hexanediol and sodium hyaluronate is 0.0002:0.02:1.5:0.03:0.003.

[0009] A further technical solution is that the Chinese medicine extract is obtained by extracting a mixture of Chinese medicines consisting of angelica sinensis, peach kernel, salvia miltiorrhiza, angelica dahurica, ophiopogon japonicus, mulberry leaf, phellodendron chinense, honeysuckle vine, astragalus, atractylodes macrocephala, horsetail grass, and alpine edelweiss.

[0010] A further technical solution is that the mass ratio of angelica sinensis, peach kernel, salvia miltiorrhiza, angelica dahurica, ophiopogon japonicus, mulberry leaf, phellodendron chinense, honeysuckle vine, astragalus, atractylodes macrocephala, horsetail grass and alpine edelweiss in the traditional Chinese medicine mixture is 1:2:3:1:2:5:2:1:2:1:1:1.5.

[0011] The second technical solution adopted by the present invention is:

[0012] A preparation method for preparing a remodeled active peptide composition as in the first technical solution, specifically comprising the following steps: step S1, wrapping a Chinese medicine mixture with gauze and then soaking it in clean water; step S2, boiling the Chinese medicine composition and water in a mass ratio of 1:3; step S3, filtering the boiled medicinal liquid, and then concentrating it to obtain a viscous Chinese medicine extract; step S4, mixing and stirring the Chinese medicine extract, an antioxidant, a moisturizer, and a solvent; step S5, sequentially adding sweet orange flower extract, bird's nest extract, and golden camellia extract to the uniformly mixed solution in step S4; step S6, sequentially adding acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7, and palmitoyl hexapeptide-12 to the mixed solvent stirred in step S5, stirring and dissolving, and freeze-drying, and packaging into small portions for storage.

[0013] Compared with the prior art, the beneficial effects of the present invention are as follows: the present invention utilizes the coordinated effect of four small peptides with anti-wrinkle effects, plus some Chinese medicine extracts and plant essences, to prepare a component with excellent anti-wrinkle effects. After use, it can be quickly absorbed by the skin, and then act on the cell level to promote the synthesis of collagen, fibronectin, glycosaminoglycans and the regeneration of true surface cells, so that skin cells can restore elasticity and vitality. Long-term use can relieve wrinkles and improve the skin, especially for static wrinkles such as nasolabial folds and crow's feet caused by loss of skin activity.

[0014] Chinese herbal extracts can help improve facial wrinkles while accelerating blood flow, promoting blood circulation in the face, and restoring the face's radiance by improving the blood supply environment on the face, which helps the face remain youthful and energetic for a long time. DETAILED DESCRIPTION

[0015] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0016] Embodiment 1:

[0017] A remodeling active peptide composition, characterized in that it is composed of acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7, palmitoyl hexapeptide-12, sweet orange flower extract, Chinese medicine extract, bird's nest extract, golden camellia extract, antioxidant, moisturizer, and solvent in a mass ratio of 1-3: 3-9: 4-7: 2-8: 2-4: 5-10: 0.5-1.5: 1-4: 1-3: 1-2: 3-15.

[0018] Acetyl hexapeptide-8 is a bioactive peptide that can inhibit the release of the neurotransmitter acetylcholine to reduce muscle contraction. It can not only reduce existing facial wrinkles, but also effectively prevent the formation of new wrinkles.

[0019] Palmitoyl Tripeptide, composed of amino acid chains, can penetrate the epidermis and penetrate deep into the layers to help stimulate collagen production and healthy tissue growth.

[0020] Palmitoyl Tetrapeptide-7 is one of many recently discovered peptides that have been cited for their positive effects on skin health. Peptides are naturally occurring chemicals, but many cosmetic companies are now synthesizing them in the lab to better control their effects on the skin. Most peptides are made up of chains of amino acids, which are directly involved in the production of proteins in the body.

[0021] Palmitoyl Tetrapeptide-7 is most commonly found in anti-aging serums, moisturizers, and certain cosmetic formulations. In studies reviewed by the Cosmetic Ingredient Review Expert Panel, results showed statistically significant improvements in skin elasticity, reductions in deep wrinkles, and improved skin texture. It was also found to have a dose-response effect on collagen 1, fibronectin, and hyaluronic acid synthesis. Collagen 1, fibronectin, and hyaluronic acid are all involved in the aging process.

[0022] Palmitoyl hexapeptide-12 (Pal-VGVAPG) is a signal peptide belonging to the Matrikine series, which is particularly related to the repair of age-related skin damage. The hexapeptide VGVAPG fragment is repeated six times in the entire molecular structure of elastin, so it is called the "spring fragment". Palmitoyl hexapeptide-12 has a chemotactic effect, which can promote the migration, proliferation and matrix macromolecule synthesis of dermal fibroblasts (such as elastin, collagen, etc.), providing support for the skin. At the same time, it can also induce fibroblasts and monocytes to specific locations to achieve wound repair and tissue renewal.

[0023] The mass ratio of acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7, and palmitoyl hexapeptide-12 is 2:5:6:7.

[0024] The moisturizer is a combination of ethylhexylglycerin, butylene glycol, glycerin, 1,2-hexanediol and sodium hyaluronate. The mass ratio of ethylhexylglycerin, butylene glycol, glycerin, 1,2-hexanediol and sodium hyaluronate is 0.0002:0.02:1.5:0.03:0.003.

[0025] The Chinese medicine extract is obtained by extracting a mixture of Chinese medicines consisting of angelica sinensis, peach kernel, salvia miltiorrhiza, angelica dahurica, ophiopogon japonicus, mulberry leaf, phellodendron chinense, honeysuckle vine, astragalus, atractylodes macrocephala, horsetail grass and alpine edelweiss.

[0026] The mass ratio of angelica sinensis, peach kernel, salvia miltiorrhiza, angelica dahurica, ophiopogon japonicus, mulberry leaf, phellodendron chinense, honeysuckle vine, astragalus, atractylodes macrocephala, horsetail herb and alpine edelweiss in the traditional Chinese medicine mixture is 1:2:3:1:2:5:2:1:2:1:1:1.5.

[0027] In the process of four peptides repairing the skin, sweet orange flower extract, Chinese medicine extract, bird's nest extract, and golden camellia extract simultaneously condition the original skin, as well as the entire facial blood supply and muscle condition. By activating muscles and speeding up blood circulation, the entire facial condition is qualitatively improved, which can make the repaired skin have better anti-wrinkle and anti-aging properties.

[0028] Sweet orange flower extract is orange blossom essential oil, and its greatest effect is on the skin. It enhances cell vitality, helps cell regeneration, and increases skin elasticity; it whitens, moisturizes, and lightens spots, and is suitable for dry, sensitive, and other problem skin.

[0029] Bird's nest can beautify the skin and make it smooth, elastic and shiny.

[0030] Camellia chrysantha original dew can maintain the normal toughness and permeability of capillaries.

[0031] Angelica sinensis nourishes blood; it activates blood circulation and relieves numbness of the skin. Angelica sinensis and Atractylodes macrocephala are used to replenish blood in the face, which keeps the blood flowing abundantly in the face for a long time, so they are both assistant drugs.

[0032] Peach kernel can promote blood circulation and remove blood stasis, making facial muscles more active.

[0033] Salvia miltiorrhiza has the effects of removing blood stasis, promoting new blood circulation and activating blood circulation.

[0034] Angelica dahurica can promote blood circulation, discharge pus, promote tissue regeneration and relieve pain. Combined with Salvia miltiorrhiza, it can revitalize the face from the muscle level.

[0035] Ophiopogon japonicus and Ophiopogon japonicus mainly contain spatholobiside, steroidal saponins, alkaloids, sitosterol, glucose, amino acids, vitamins, etc. They have the effects of resisting fatigue, scavenging free radicals, improving cellular immune function and lowering blood sugar.

[0036] Winter mulberry leaves can treat blood deficiency headaches and eye fatigue.

[0037] Huangbai can relieve red and swollen eyes. After making the eyes comfortable, it is also good for the facial skin around the eyes. It is necessary to prevent patients from rubbing the area around the eyes due to eye discomfort, which may cause redness and swelling of the skin.

[0038] Honeysuckle vine has antibacterial and anti-inflammatory effects, and can play an auxiliary role in repairing the skin.

[0039] Astragalus can be combined with various traditional Chinese medicines in the present invention to replenish qi and promote tissue regeneration for users.

[0040] Horsetail grass and horsetail grass can also help remove excess oil from the skin and hair, making hair grow healthier, thicker and more elastic

[0041] Alpine edelweiss is rich in minerals and has soothing, calming, whitening, nourishing and protective effects on the skin. It removes epidermal oils and dirt in the pores, while relieving skin tension, making it soft and not tight. The natural whitening ingredients can penetrate into the skin, help decompose and metabolize impurities, and prevent pigmentation. After use, the skin will be smooth, delicate, fair and shiny.

[0042] Embodiment 2:

[0043] A preparation method for preparing a remodeling active peptide composition as in Example 1, specifically comprising the following steps: step S1, wrapping a Chinese medicine mixture with gauze and then soaking it in clean water; step S2, boiling the Chinese medicine composition and water in a mass ratio of 1:3; step S3, filtering the boiled medicinal liquid, and then concentrating it to obtain a viscous Chinese medicine extract; step S4, mixing and stirring the Chinese medicine extract, an antioxidant, a moisturizer, and a solvent; step S5, sequentially adding sweet orange flower extract, bird's nest extract, and golden camellia extract to the uniformly mixed solution in step S4; step S6, sequentially adding acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7, and palmitoyl hexapeptide-12 to the mixed solvent stirred in step S5, stirring and dissolving, and freeze-drying, and packaging into small portions for storage.

[0044] Embodiment 3:

[0045] Based on Example 1, a remodeling active peptide composition is composed of acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7, palmitoyl hexapeptide-12, sweet orange flower extract, Chinese medicine extract, bird's nest extract, golden camellia extract, antioxidants, moisturizers, and solvents in a mass ratio of 2:3:7:3:3:8:0.5:1:3:1:10.

[0046] Comparative test:

[0047] 30 people aged between 28 and 35 were recruited from the same region and divided into two groups, A and B, with 5 people in each group; 10 people aged between 35 and 45 were divided into two groups, C and D, with 5 people in each group; 10 people aged between 45 and 50 were divided into two groups, E and F, with 5 people in each group. A remodeling active peptide composition prepared in Example 2 was applied to the faces of A, C, and E. A commonly used brand repair essence on the market was applied to the faces of B, D, and F for 4 consecutive weeks.

[0048] The German MAP580 skin tester was used to test and the tensile strength Ue of the positioning elastic part was obtained comprehensively. The higher the data value, the better the skin elasticity. As shown in Table 1

[0049] Table 1. Skin elasticity test table

[0050] Group A Group B Group C Group D Group E Group F After 2 weeks of use 0.2936 0.2421 0.2854 0.1955 0.2732 0.1866 After 4 weeks of use 0.3152 0.2611 0.3015 0.2453 0.2932 0.2433

[0051] The VISIA facial image analyzer was used to test and obtain the wrinkle reduction rate data compared with the first day. The higher the wrinkle reduction rate, the better the ability to reduce expression lines. The test results are shown in Table 2.

[0052] Table 2. Wrinkle reduction rate data table

[0053]

[0054] It can be seen from the above table that in different age groups, the remodeling active peptide composition prepared by the present invention has great advantages in anti-wrinkle and restoration of skin elasticity compared with mainstream products on the market, and can remodel the user's skin, restore its luster and elasticity, and reduce wrinkles.

[0055] Although the invention has been described herein with reference to a number of illustrative embodiments thereof, it should be understood that numerous other modifications and implementations can be devised by those skilled in the art that will fall within the scope and spirit of the principles disclosed herein.

Claims

1. A remodeling active peptide composition, characterized in that: It is composed of acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7, palmitoyl hexapeptide-12, sweet orange flower extract, Chinese medicine extract, bird's nest extract, golden camellia extract, antioxidant, moisturizer and solvent in a mass ratio of 1-3:3-9:4-7:2-8:2-4:5-10:0.5-1.5:1-4:1-3:1-2:3-15.

2. A remodeling active peptide composition according to claim 1, characterized in that: The mass ratio of acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7 and palmitoyl hexapeptide-12 is 2:5:6:

7.

3. A remodeling active peptide composition according to claim 1, characterized in that: The moisturizing agent is a compound of ethylhexylglycerin, butylene glycol, glycerin, 1,2-hexanediol and sodium hyaluronate, and the mass ratio of ethylhexylglycerin, butylene glycol, glycerin, 1,2-hexanediol and sodium hyaluronate is 0.0002:0.02:1.5:0.03:0.

003.

4. A remodeling active peptide composition according to claim 1, characterized in that: The Chinese medicine extract is obtained by extracting a Chinese medicine mixture consisting of angelica sinensis, peach kernel, salvia miltiorrhiza, angelica dahurica, ophiopogon japonicus, mulberry leaf, phellodendron chinense, honeysuckle vine, astragalus, atractylodes macrocephala, horsetail grass and alpine edelweiss.

5. A remodeling active peptide composition according to claim 1, characterized in that: The mass ratio of angelica sinensis, peach kernel, salvia miltiorrhiza, angelica dahurica, ophiopogon japonicus, mulberry leaf, phellodendron chinense, honeysuckle vine, astragalus, atractylodes macrocephala, horsetail grass and alpine edelweiss in the traditional Chinese medicine mixture is 1:2:3:1:2:5:2:1:2:1:1:1.

5.

6. A preparation method, characterized in that: The method for preparing a remodeling active peptide composition as claimed in claim 4 specifically comprises the following steps: Step S1, wrapping the Chinese medicine mixture with gauze and then soaking it in clean water; Step S2, boiling the Chinese medicine composition and water in a mass ratio of 1:3; Step S3, filtering the boiled medicinal liquid, and then concentrating it to obtain a viscous Chinese medicinal extract; Step S4, mixing the Chinese herbal extract, the antioxidant, the moisturizer, and the solvent; Step S5, adding the sweet orange flower extract, the bird's nest extract, and the golden camellia extract to the evenly mixed solution in step S4 in sequence; Step S6, acetyl hexapeptide-8, palmitoyl tripeptide, palmitoyl tetrapeptide-7, and palmitoyl hexapeptide-12 are sequentially added to the mixed solvent stirred in step S5, stirred to dissolve, and then freeze-dried, and packaged into small portions for storage.

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