A traditional Chinese medicine composition with hypoglycemic efficacy and a preparation method thereof

Abstract

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition with hypoglycemic effect and a preparation method thereof.The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-23 parts of Astragalus membranaceus, 12-18 parts of Sambucus williamsii root, 10-15 parts of Fructus Corni, 5-8 parts of Artemisia argyi stem, 1-5 parts of Fructus Camptothecae, 1-5 parts of Rhamnus utilis, 3-8 parts of Pueraria lobata, 1-5 parts of Morus alba leaf, and 1-3 parts of Radix Glycyrrhizae.The components of the traditional Chinese medicine composition are compatible with each other according to a certain ratio, can tonify qi and raise yang, dredge Sanjiao, expel evil, promote blood circulation and unblock collaterals, jointly achieve the effects of tonifying qi and nourishing, promoting qi and relieving pain, and tonifying kidney and dredging collaterals, can reduce blood sugar content, protect the cardiovascular system, achieve the effects of preventing and treating diabetes, and have practicality and application value.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition with hypoglycemic effect and a preparation method thereof. BACKGROUND

[0002] Diabetes is a global health problem, and in recent years, the number of people with diabetes has continued to grow. Among them, type 2 diabetes (T2DM) is one of the common types, which is mainly caused by the interaction of genetic factors and environmental factors, and is manifested as different degrees of insulin resistance, dysfunction of pancreatic beta and alpha cells and other endocrine disorders. When the beta cells cannot secrete enough insulin to overcome insulin resistance, T2DM occurs.

[0003] At present, the treatment of diabetes mainly includes drug therapy, diet control and exercise therapy. In terms of drug therapy, commonly used hypoglycemic drugs include insulin, sulfonylureas, biguanides, glinides, alpha-glucosidase inhibitors and thiazolidinediones, etc. However, these drugs may have some side effects, such as hypoglycemia, weight gain, gastrointestinal discomfort, etc., and some patients may develop resistance or inadaptation to certain drugs. The traditional Chinese medicine composition, with its multi-component compatibility characteristics, can help to make up for the shortcomings of existing treatment methods and provide a more gentle and comprehensive treatment effect. Compared with some expensive Western medicines and insulin, the cost of the traditional Chinese medicine composition may be lower, which helps to reduce the economic burden of patients. In addition, the preparation and use of the traditional Chinese medicine composition are relatively simple, which is convenient for patients to use at home, improving the convenience and operability of treatment.

[0004] Traditional Chinese medicine theory believes that most of the high blood sugar is related to kidney yin deficiency and lung and stomach fire. Diabetes belongs to the category of "consumption", and its etiology and pathogenesis are related to factors such as yin deficiency and dryness-heat, spleen and stomach weakness, and deficiency of both qi and blood. There are various methods for treating diabetes with traditional Chinese medicine, including herbal medicine, acupuncture, massage, etc., aiming to regulate the balance of yin and yang, the function of viscera, etc., to achieve the purpose of treating diseases. Although a variety of Chinese herbal medicines have been used for hypoglycemic treatment, different Chinese herbal medicine ingredients are complex, and if they are directly mixed and used, they may have poor efficacy or even side effects due to drug efficacy conflict or improper proportioning.

[0005] Therefore, it is of important clinical significance and application value to develop a pure traditional Chinese medicine composition to achieve the effect of reducing blood sugar through the mutual compatibility of each substance. SUMMARY

[0006] In order to overcome the shortcomings of the prior art, the primary purpose of the present application is to provide a traditional Chinese medicine composition with hypoglycemic effect.

[0007] The purpose of the present application is achieved by the following technical solutions:

[0008] A traditional Chinese medicine composition with hypoglycemic efficacy, comprising the following raw materials in parts by weight: 15-23 parts of Astragalus, 12-18 parts of Sambucus williamsii, 10-15 parts of Fructus Corni, 5-8 parts of Artemisia argyi stem, 1-5 parts of Fructus Camptothecae, 1-5 parts of Ruscus aculeatus, 3-8 parts of Pueraria, 1-5 parts of Mulberry leaf, 1-3 parts of Radix Glycyrrhizae.

[0009] Further, comprising the following raw materials in parts by weight: 20 parts of Astragalus, 15 parts of Sambucus williamsii, 12 parts of Fructus Corni, 6 parts of Artemisia argyi stem, 3 parts of Fructus Camptothecae, 3 parts of Ruscus aculeatus, 5 parts of Pueraria, 3 parts of Mulberry leaf, 2 parts of Radix Glycyrrhizae.

[0010] The pharmacological analysis of the raw materials used in the application is as follows:

[0011] Astragalus, also known as Northeast Astragalus and Membrane Pod, is a perennial herb. Astragalus has the effects of tonifying qi and ascending yang, consolidating the exterior and stopping sweating, promoting water and reducing swelling, generating fluid and nourishing blood, removing stagnation and relieving arthralgia, and astringing and promoting tissue regeneration. It is used for treating all qi deficiency and blood deficiency syndromes, and can be used to treat qi deficiency, middle-qi collapse, exterior deficiency with spontaneous sweating, edema, internal heat and polydipsia, hemiplegia, arthralgia and numbness, etc.

[0012] Sambucus williamsii: sweet, flat, has the effects of invigorating deficiency and removing blood stasis, clearing heat and reducing dampness. It is used for treating hepatitis, dysentery, malaria, phthisis, cough and asthma, hernia, edema, metrorrhagia and leukorrhea. The Southern Yunnan Herbal records that Sambucus williamsii has the effects of ascending and descending liver qi, promoting urination, reducing edema, purging stomach fire and heat, treating jaundice, stopping liver qi pain, and treating hernia pain.

[0013] Fructus Corni: sour and astringent in nature, slightly warm in property, and belongs to liver and kidney meridians. It has the effects of tonifying liver and kidney and astringing essence and preventing leakage. It is used for tonifying liver and kidney, astringing essence, tonifying liver and kidney, and preventing leakage. It is used for treating liver and kidney deficiency, astringing essence, tonifying liver and kidney, and preventing leakage. It is used for treating liver and kidney deficiency, astringing essence, tonifying liver and kidney, and preventing leakage. The Daily Chinese Herbal Medicine records that it can warm the waist and knees, assist water and viscera, dispel all wind, expel all qi, break nodules, and treat alcohol-induced dizziness.

[0014] Artemisia argyi stem: pungent and sweet in taste, and cool in nature. It belongs to heart, spleen and stomach meridians. It has the effects of invigorating the spleen and stomach, calming the heart and mind, regulating qi and resolving phlegm. It is used for treating spleen and stomach disharmony, and invigorating the spleen and stomach.

[0015] Fructus Camptothecae: cold in nature, bitter and astringent in taste, and belongs to spleen, stomach and liver meridians. It has the effects of resolving nodules and treating diseases. Jiangxi Chinese Herbal Medicine records that it has the effects of treating cancer and resolving nodules, and is effective for stomach cancer, rectal cancer and bladder cancer.

[0016] Ruscus aculeatus: pungent and slightly bitter in taste, and warm in nature. It has the effects of dispelling wind, resolving inflammation and pain, killing insects and relieving itching. It has the effects of expanding blood vessels and improving blood circulation in the heart.

[0017] Pueraria: sweet in taste, pungent in nature, and belongs to spleen and stomach meridians. It has the effects of ascending yang and stopping diarrhea, promoting blood circulation and relieving alcohol toxicity. The Shennong Herbal Classic records that it is used for treating polydipsia and high fever.

[0018] Mulberry leaf: bitter, sweet, cold. Lung, liver meridian. Has dispelling wind-heat, clear lung dryness, liver clear, blood stasis, cooling. According to the record of “Ben Cao Fen Jing” its “bitter and sweet and cool. Moist dry blood, stop bleeding, wind, clear and less yang heat.”

[0019] Baked licorice: sweet, flat; into the spleen, stomach, lung. Treatment of spleen and stomach weakness, less food, abdominal pain and diarrhea, tired fever, lung cough, palpitations, convulsions; raw, treatment of sore throat, peptic ulcer, carbuncle, ulcer, drug poisoning and food poisoning. “Ben Jing” records that it can treat five zang six fu cold and heat evil, strengthen bones and muscles, increase strength, gold, swelling, detoxification.

[0020] Another object of the present application is to provide a preparation method of the above-mentioned traditional Chinese medicine composition with hypoglycemic effect.

[0021] The object of the present application is achieved by the following technical solutions:

[0022] The preparation method of the above-mentioned traditional Chinese medicine composition with hypoglycemic effect comprises the following steps:

[0023] According to the above weight, each raw material is weighed, crushed, mixed uniformly, soaked and decocted with water, filtered and collected after decoction, the filter residue is soaked and decocted with water again, filtered, and the two filtrates are combined, concentrated to a relative density of 1.0-1.1 of the extract, and the extract is mixed with a pharmaceutically acceptable excipient to form a corresponding dosage form.

[0024] Further, the total mass of each raw material and the mass of water is 1:(6-10).

[0025] Further, the soaking time is 1-2h, and the decoction temperature is 90-100℃, and the time is 60-120min.

[0026] Further, the mesh size of the screen is 50-100 mesh.

[0027] Further, the dosage form is an oral dosage form.

[0028] Further, the oral dosage form is any one of oral liquid, tablet, pill, granule and capsule.

[0029] The present application has the following effects compared with the prior art:

[0030] 1.The present application provides a traditional Chinese medicine composition with hypoglycemic effect, in which Huangqi, Jiegucao root, Shanzhuyu tonify qi and raise yang, invigorate the spleen and clear heat, and Xishuguo dispel stagnation and dissipate masses, all of which are the monarch drugs; Qingqianliu, Gegen and Sangye clear heat and cool blood, all of which are the minister drugs; and Zhigancao is used to harmonize all the drugs, so it is the assistant drug. The combination of all the components can tonify qi and raise yang, dredge the Sanjiao, dispel evil, invigorate the circulation of blood, and achieve the effects of tonifying qi and nourishing, promoting the circulation of qi and relieving pain, and invigorating the kidney and dredging the collaterals, which can lower the blood glucose content, protect the cardiovascular system, achieve the effects of preventing and treating diabetes, and have practicality and application value.

[0031] 2.The traditional Chinese medicine composition of the present application follows the principle of monarch, minister, assistant and guide, has a reasonable compatibility relationship, conforms to the theory of traditional Chinese medicine, and has high safety, which can provide a new treatment idea for preventing and treating diabetes. BRIEF DESCRIPTION OF DRAWINGS

[0032] Figure 1 Figure is the result graph of the effect of the traditional Chinese medicine composition decoction of the present application on the liver function index of rat serum;

[0033] Figure 2 Figure is the result graph of the effect of the traditional Chinese medicine composition decoction of the present application on the kidney function index of rat serum. DETAILED DESCRIPTION

[0034] The present application will be further described in detail below in combination with examples, but the implementation of the present application is not limited thereto. Unless otherwise specified, the reagents, methods and devices used in the present application are conventional reagents, methods and devices in the technical field. Unless otherwise specified, the test methods in the following examples are usually carried out according to conventional experimental conditions or according to the experimental conditions suggested by the manufacturer. Unless otherwise specified, the reagents and raw materials used in the present application are commercially available.

[0035] Example 1

[0036] A traditional Chinese medicine composition with hypoglycemic effect, the weight ratio of raw materials is as follows: Huangqi 20 parts, Jiegucao root 15 parts, Shanzhuyu 12 parts, Haizilu 6 parts, Xishuguo 3 parts, Qingqianliu 3 parts, Gegen 5 parts, Sangye 3 parts, and Zhigancao 2 parts.

[0037] The preparation method of the traditional Chinese medicine composition with hypoglycemic effect is as follows:

[0038] The Astragalus, Sambucus williamsii Hance, Fructus Corni, Artemisia root, Fructus Camptothecae, Rhamnus utilis, Pueraria, Folium Mori, and Radix Glycyrrhizae are weighed, respectively pulverized and passed through an 80-mesh sieve, mixed, and then soaked in 8 times the amount of water for 1.5 hours; the mixed solution is boiled at 95°C for 90 minutes, then filtered with gauze, and the filtrate is collected and the residue is reserved; the residue is soaked in 8 times the amount of water for 1.5 hours, boiled at 95°C for 90 minutes, and filtered to obtain the filtrate; and the two filtrates are combined and concentrated at 65°C until the relative density of the extract is 1.0, thereby obtaining the traditional Chinese medicine composition.

[0039] The example also includes a step of preparing the traditional Chinese medicine composition into a capsule: the extract is dried and pulverized, and then filled into a capsule as a capsule powder to prepare a capsule.

[0040] Example 2

[0041] A traditional Chinese medicine composition with hypoglycemic efficacy, the weight ratio of the raw materials is as follows: 15 parts of Astragalus, 12 parts of Sambucus williamsii Hance, 10 parts of Fructus Corni, 5 parts of Artemisia root, 1 part of Fructus Camptothecae, 1 part of Rhamnus utilis, 3 parts of Pueraria, 1 part of Folium Mori, and 1 part of Radix Glycyrrhizae.

[0042] The preparation method of the traditional Chinese medicine composition with hypoglycemic efficacy is as follows:

[0043] The Astragalus, Sambucus williamsii Hance, Fructus Corni, Artemisia root, Fructus Camptothecae, Rhamnus utilis, Pueraria, Folium Mori, and Radix Glycyrrhizae are weighed, respectively pulverized and passed through a 50-mesh sieve, mixed, and then soaked in 6 times the amount of water for 1 hour; the mixed solution is boiled at 90°C for 120 minutes, then filtered with gauze, and the filtrate is collected and the residue is reserved; the residue is soaked in 6 times the amount of water for 1 hour, boiled at 90°C for 120 minutes, and filtered to obtain the filtrate; and the two filtrates are combined and concentrated at 65°C until the relative density of the extract is 1.0, thereby obtaining the traditional Chinese medicine composition.

[0044] The example also includes a step of preparing the traditional Chinese medicine composition into granules: xylitol is added to the extract, and then granules are prepared by a conventional method.

[0045] Example 3

[0046] A traditional Chinese medicine composition with hypoglycemic efficacy, the weight ratio of the raw materials is as follows: 23 parts of Astragalus, 18 parts of Sambucus williamsii Hance, 15 parts of Fructus Corni, 8 parts of Artemisia root, 5 parts of Fructus Camptothecae, 5 parts of Rhamnus utilis, 8 parts of Pueraria, 5 parts of Folium Mori, and 3 parts of Radix Glycyrrhizae.

[0047] The preparation method of the traditional Chinese medicine composition with hypoglycemic efficacy is as follows:

[0048] The Astragalus, Kuzhucao root, Cornus officinalis, Huozituo branch, Camptotheca acuminata fruit, Cyclobalanopsis glauca, Pueraria, mulberry leaves, and licorice are weighed, ground, and passed through a 100-mesh sieve. The mixture is soaked in 10 times the amount of water for 2 hours. The mixture is boiled at 100°C for 60 minutes, filtered with gauze, and the filtrate is collected. The residue is soaked in 10 times the amount of water for 2 hours, boiled at 100°C for 60 minutes, and filtered. The two filtrates are combined and concentrated at 65°C until the relative density of the extract is 1.0. The Chinese medicine composition is obtained.

[0049] The example also includes a step of preparing the Chinese medicine composition into an oral liquid by adding xylitol to the extract and using conventional methods to prepare the oral liquid.

[0050] Comparative Example 1

[0051] This comparative example provides a Chinese medicine composition with hypoglycemic efficacy. The difference from Example 1 is that Kuzhucao root is omitted, and the other components are the same as in Example 1.

[0052] Comparative Example 2

[0053] This comparative example provides a Chinese medicine composition with hypoglycemic efficacy. The difference from Example 1 is that the amount of Kuzhucao root is adjusted to 25 parts, and the other components are the same as in Example 1.

[0054] Comparative Example 3

[0055] This comparative example provides a Chinese medicine composition with hypoglycemic efficacy. The difference from Example 1 is that the amount of Kuzhucao root is adjusted to 5 parts, and the other components are the same as in Example 1.

[0056] Comparative Example 4

[0057] This comparative example provides a Chinese medicine composition with hypoglycemic efficacy. The difference from Example 1 is that Huozituo branch is omitted, and the other components are the same as in Example 1.

[0058] Comparative Example 5

[0059] This comparative example provides a Chinese medicine composition with hypoglycemic efficacy. The difference from Example 1 is that Camptotheca acuminata fruit is omitted, and the other components are the same as in Example 1.

[0060] The following are the effect tests of Examples 1-3 and Comparative Examples 1-5.

[0061] Test Example 1

[0062] Safety experiment: 8-10 weeks old, SPF level SD rats, half male and half female, body weight 240-280 g, feeding environment for clean laboratory, temperature 25℃, relative humidity maintained at 55%, the rat bedding changed every day, set 12 hours light and 12 hours dark cycle, adaptive feeding for 7 days, during which the rats were free to eat and drink. Then the rats were randomly divided into Example 1 high dose group: 8g (crude drug) / kg, Example 1 low dose group: 2g (crude drug) / kg, Example 1 medium dose group: 4g (crude drug) / kg, blank control group, 6 rats in each group, Example 1 high, low and medium dose groups were given corresponding doses of Example 1 prepared traditional Chinese medicine composition by gavage for 60 days, and the blank control group was given the same amount of normal saline. The rats were weighed every other day, then the blood samples were collected by enucleation of the eyeball for blood routine analysis, the collected blood was centrifuged at 4000 rpm for 10 min, and the supernatant was detected by automatic biochemical analyzer for liver function indicators alanine aminotransferase (ALT), aspartate aminotransferase (AST) and kidney function indicators creatinine (CR), blood urea nitrogen (BUN) and the like, and the test results are shown in Figure 1 and Figure 2 .

[0063] Compared with the blank control group, the rats were given the traditional Chinese medicine composition of the application by gavage, and the rats' behavior, defecation and urination, drinking and eating, mental state were good, and there was no death and adverse phenomenon. From the detection results of Figure 1 and Figure 2 , compared with the blank control group, after feeding with the low, medium and high dose traditional Chinese medicine composition of Example 1, no obvious abnormality was found in the liver function indicators and kidney function indicators in the serum of the rats, indicating that the traditional Chinese medicine composition of the application would not produce obvious toxic and side effects on animals, and could be used for subsequent experimental research.

[0064] Test Example 2

[0065] 1. Test animal grouping

[0066] 8-10 weeks old, SPF level SD rats, half male and half female, body weight 240-280 g, feeding environment for clean laboratory, temperature 25℃, relative humidity maintained at 55%, the rat bedding changed every day, set 12 hours light and 12 hours dark cycle, adaptive feeding for 7 days, during which the rats were free to eat and drink. Then the rats were randomly divided into Example 1 high dose group, Example 1 medium dose group, Example 1 low dose group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 3 group, Comparative Example 4 group, Comparative Example 5 group, model group, blank control group, positive control group, 10 rats in each group.

[0067] 2. Construction of rat diabetes model

[0068] STZ was dissolved in sodium citrate buffer with pH 4.0 to prepare a STZ solution with a concentration of 1.0% for standby. The rats in the blank control group were not treated (given normal feed), and the other rats were injected with the STZ solution at a dose of 20 mg / kg via the tail vein, and were fed with high-fat feed for 6 weeks after 3 days of injection; the rats were fasted for 12 h without water, and blood was taken from the tail vein to detect the blood glucose level of the rats. It was observed that the rats were listless and obese, and the fasting blood glucose level was higher than 11.1 mmol / L, indicating that the rat model of diabetes was successfully constructed.

[0069] 3. Drug treatment

[0070] After the model was successfully constructed, the rats in each group were given drugs in the following manner:

[0071] Example 1 low-dose group: the rats were given the traditional Chinese medicine composition prepared in Example 1 at 2 g / kg per day by gavage;

[0072] Example 1 medium-dose group: the rats were given the traditional Chinese medicine composition prepared in Example 1 at 4 g / kg per day by gavage;

[0073] Example 1 high-dose group: the rats were given the traditional Chinese medicine composition prepared in Example 1 at 8 g / kg per day by gavage;

[0074] Comparative Example 1 group: the rats were given the traditional Chinese medicine composition prepared in Comparative Example 1 at 8 g / kg per day by gavage;

[0075] Comparative Example 2 group: the rats were given the traditional Chinese medicine composition prepared in Comparative Example 2 at 8 g / kg per day by gavage;

[0076] Comparative Example 3 group: the rats were given the traditional Chinese medicine composition prepared in Comparative Example 3 at 8 g / kg per day by gavage;

[0077] Comparative Example 4 group: the rats were given the traditional Chinese medicine composition prepared in Comparative Example 4 at 8 g / kg per day by gavage;

[0078] Comparative Example 5 group: the rats were given the traditional Chinese medicine composition prepared in Comparative Example 5 at 8 g / kg per day by gavage;

[0079] Blank control group: the rats were given an equal volume of normal saline by gavage per day;

[0080] Positive control group: the rats were given metformin (at a dose of 0.25 g / kg) by gavage;

[0081] Model group: the rats were given an equal volume of normal saline by gavage;

[0082] The rats were continuously given drugs by gavage for 28 days. The blood glucose and body weight changes of the rats were measured before drug administration (i.e. on the first day after the model was successfully constructed) and after 28 days of drug administration, and the test results are recorded in Tables 1 and 2.

[0083] Table 1 blood glucose levels of rats before and after administration

[0084]

[0085] From the experimental results of Table 1, it can be seen that the blood glucose value of the model group rats is obviously increased compared with the normal control group, which indicates that the rat diabetes model is successfully constructed. Compared with the model group, the blood glucose of the rats of the low, medium and high dose groups of Example 1 and the positive control group is obviously decreased on the 28th day after administration, and the blood glucose level is reduced to be similar to that of the positive administration group after the treatment of the high dose group of Example 1, which indicates that the traditional Chinese medicine composition of the application has good hypoglycemic effect.

[0086] After the Sambucus williamsii Hance root is omitted in Comparative Example 1, the blood glucose reduction level is obviously reduced, which indicates that the Sambucus williamsii Hance root can tonify qi and raise yang in the traditional Chinese medicine composition and plays an important role in reducing blood glucose level. After the amount of Sambucus williamsii Hance root is adjusted in Comparative Examples 2 and 3, the blood glucose reduction level is not as good as that of the low, medium and high dose groups of Example 1, which indicates that the amount of Sambucus williamsii Hance root in the prescription needs to be controlled in a reasonable range. After the Artemisia japonica Hance stem is omitted in Comparative Example 4 and the Camptotheca acuminata fruit is omitted in Comparative Example 5, the blood glucose level of the rats is reduced, but the treatment effect is far less than that of the high dose group of Example 1. It indicates that the Artemisia japonica Hance stem and the Camptotheca acuminata fruit can be matched with each component in the traditional Chinese medicine to jointly reduce the blood glucose level.

[0087] Table 2 body weight changes of rats before and after administration

[0088]

[0089] From the experimental data of Table 2, it can be seen that the body weight of the rats of the low, medium and high dose groups of Example 1 is obviously reduced compared with the model group, which indicates that the above treatment can reduce the body weight of the diabetic model rats. After the amount of Sambucus williamsii Hance root is adjusted in Comparative Examples 1 to 3, the degree of body weight reduction of the rats is reduced. Although the body weight of the rats of Comparative Examples 4 and 5 is reduced, the effect is far less than that of the high dose group of Example 1.

[0090] The above embodiments are only preferred embodiments of the application, and cannot be used to limit the protection scope of the application, and any non-substantial changes and substitutions made by those skilled in the art on the basis of the application all belong to the protection scope of the application.

Claims

1. A traditional Chinese medicine composition with hypoglycemic effect, characterized in that, It is composed of the following raw materials in parts by weight: Astragalus membranaceus 15-23 parts, Sambucus chinensis root 12-18 parts, Cornus officinalis 10-15 parts, Artemisia argyi stem 5-8 parts, Camptotheca acuminata fruit 1-5 parts, Eucommia ulmoides 1-5 parts, Pueraria lobata root 3-8 parts, Morus alba leaf 1-5 parts, and Glycyrrhiza uralensis (processed) 1-3 parts.

2. The traditional Chinese medicine composition with hypoglycemic effect according to claim 1, characterized in that, It consists of the following ingredients in parts by weight: 20 parts Astragalus membranaceus, 15 parts Sambucus chinensis root, 12 parts Cornus officinalis, 6 parts Artemisia argyi stem, 3 parts Camptotheca acuminata fruit, 3 parts Eucommia ulmoides, 5 parts Pueraria lobata root, 3 parts Morus alba leaf, and 2 parts prepared licorice root.

3. The method for preparing the traditional Chinese medicine composition with hypoglycemic effect as described in claim 1 or 2, characterized in that, Includes the following steps: Weigh each raw material according to the stated weight proportions, pulverize and sieve, mix evenly, soak and decoct in water, filter and collect the filtrate after decoction; soak the filter residue in water again, decoct and filter; combine the two filtrates, concentrate to an extract with a relative density of 1.0-1.1, add pharmaceutically acceptable excipients to the extract to prepare an oral dosage form.

4. The method for preparing the traditional Chinese medicine composition with hypoglycemic effect according to claim 3, characterized in that, The mass ratio of the total mass of the raw materials to water is 1:(6~10).

5. The method for preparing the traditional Chinese medicine composition with hypoglycemic effect according to claim 3, characterized in that, The soaking time for both soakings is 1-2 hours; the temperature for both decoctings is 90-100℃, and the time is 60-120 minutes.

6. The method for preparing the traditional Chinese medicine composition with hypoglycemic effect according to claim 3, characterized in that, The sieve mesh size is 50-100 mesh.

7. The method for preparing the traditional Chinese medicine composition with hypoglycemic effect according to claim 3, characterized in that, The oral dosage form is any one of oral liquid, tablet, pill, granule, or capsule.

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