Supramolecular panthenol composition, application and cosmetics

Abstract

The invention belongs to the field of daily chemicals, and discloses a supramolecular panthenol composition which comprises the following components in parts by weight: 70-80 parts of panthenol; and 20 to 30 parts of L-carnitine. The composition can effectively improve the panthenol skin feeling, improve the antibacterial performance and improve the skin repairing capacity by promoting cell proliferation. Meanwhile, the invention further discloses application of the composition and cosmetics.

Description

Technical Field

[0001] The invention relates to the field of daily chemicals, and in particular to a supramolecular panthenol composition, use and cosmetics. Background Art

[0002] Supramolecular molecules usually refer to two or more molecules that are combined together by intermolecular interactions to form complex, organized aggregates that maintain a certain integrity and have clear microstructures and macroscopic properties.

[0003] Panthenol itself has a relatively obvious sticky feeling on the skin. In order to overcome this unpleasant skin feeling, the prior art solves this problem by making panthenol form a supramolecule, as follows:

[0004] Publication No. CN116270388A, a patent application for a supramolecule for improving the sticky skin feel of panthenol and its application, which improves the skin feel by constructing a panthenol supramolecule;

[0005] For the present invention, we not only pursue the improvement of skin feel, but we also hope that the raw materials of the present invention have other functions, such as skin repair performance.

[0006] The technical problem solved in this case is how to improve the skin feel and other comprehensive properties of panthenol supramolecules. Summary of the invention

[0007] The purpose of the present invention is to provide a supramolecular panthenol composition, which can effectively improve the skin feel of panthenol and enhance the skin repair ability.

[0008] Meanwhile, the invention also discloses an application of the composition and cosmetics.

[0009] To achieve the above objectives, this application discloses:

[0010] A supramolecular panthenol composition comprises the following components in parts by weight:

[0011] Panthenol 70-80 parts;

[0012] 20-30 parts of L-carnitine.

[0013] The present invention uses the CREST program to perform conformational analysis on the monomers and complexes of panthenol and L-carnitine, and obtains 118 conformations within 4 kcal / mol of panthenol, 38 conformations within 10 kcal / mol of L-carnitine, and 148 conformations within 4 kcal / mol of panthenol-L-carnitine complex at the xtb level; the binding free energy of panthenol and L-carnitine is calculated to be -21.3 kcal / mol at the M06-2X / 6-311++G(d,p) / / 6-31+G(d,p) level, indicating that there is a strong interaction between the two. Further analysis of the most stable structure of the complex found that there are multiple hydrogen bond interactions in the complex. Among them, in addition to the hydroxyl group of L-carnitine itself forming a hydrogen bond with the carboxylate, the three hydroxyl groups of panthenol can form a hydrogen bond with the carboxylate of L-carnitine. At the same time, the positive ion region will have an electrostatic interaction with the carbonyl group.

[0014] refer to Figure 1 , Figure 1 This is a schematic diagram of the reaction of panthenol and L-carnitine forming a supramolecule;

[0015] refer to Figure 2 , Figure 2 It is a molecular schematic diagram of the supramolecular structure of panthenol and L-carnitine;

[0016] refer to Figure 3 , Figure 3 It is the distribution of the van der Waals surface electrostatic potential of the molecules in the supramolecular structure, showing a schematic diagram of the electrostatic interaction area;

[0017] refer to Figure 4 , Figure 4 It is a schematic diagram to further clarify the hydrogen bonding and electrostatic interactions through IRI analysis;

[0018] Through the above analysis, it can be clearly known that panthenol and L-carnitine can constitute supramolecular compounds; through application functional testing, it is found that compared with other panthenol supramolecular compounds, it has better skin feel. At the same time, the supramolecular has certain antibacterial ability and skin repair ability. By using L-carnitine, the antibacterial ability of panthenol is further improved.

[0019] The supramolecular panthenol composition further comprises:

[0020] 3-8 parts of oligofructose.

[0021] Oligofructose is involved in the supramolecular composition. Oligofructose is also called fructooligosaccharide or sucrose trisaccharide oligosaccharide. Oligofructose is present in many commonly consumed fruits and vegetables.

[0022] Oligofructose participates in the supramolecular structure, which can further improve the skin feel and reduce the stickiness caused by panthenol. At the same time, it can further improve the antibacterial ability and skin repair ability. The reasons are:

[0023] Panthenol is a widely used skin care ingredient. Although it has excellent repair effects, excessive use can cause the product to feel sticky. Fructo-oligosaccharide is a natural oligosaccharide that can absorb moisture from the air, help regulate the moisture balance of the skin, and reduce the stickiness of panthenol. Fructo-oligosaccharide can destroy the cell wall and cell membrane of bacteria, affect the energy metabolism of cells and organelles, and the selective permeability of substances, causing microorganisms to lose nutrition and cause their growth to stagnate, achieving the purpose of antibacterial. It also increases the expression of tight junction proteins in the skin, and synergizes with panthenol to repair the skin barrier.

[0024] The supramolecular panthenol composition comprises the following components in parts by weight:

[0025] Panthenol 75-80 parts;

[0026] 20-25 parts of L-carnitine;

[0027] 4-7 parts of oligofructose.

[0028] At the same time, the present invention also discloses the use of any of the supramolecular panthenol compositions described above in preparing cosmetics.

[0029] Finally, the present invention also discloses a cosmetic comprising any of the supramolecular panthenol compositions described above.

[0030] In the above cosmetics, the supramolecular panthenol composition contains 0.1-7 wt %.

[0031] This application has at least the following beneficial effects:

[0032] The present invention uses panthenol and L-carnitine to form a supramolecular compound, and through application functional testing, it is found that the supramolecular compound has a better skin feel than other panthenol supramolecular compounds. At the same time, the supramolecular compound has certain antibacterial ability and skin repair ability. By using L-carnitine, the antibacterial ability of panthenol is further improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 This is a schematic diagram of the reaction of panthenol and L-carnitine forming a supramolecule;

[0034] Figure 2 It is a molecular schematic diagram of the supramolecular structure of panthenol and L-carnitine;

[0035] Figure 3It is the distribution of the van der Waals surface electrostatic potential of the molecules in the supramolecular structure, showing a schematic diagram of the electrostatic interaction area;

[0036] Figure 4 It is a schematic diagram to further clarify the hydrogen bonding and electrostatic interactions through IRI analysis;

[0037] Figure 5 These are the results of nuclear magnetic resonance testing of panthenol and L-carnitine.

[0038] Specific embodiment

[0039] Below in conjunction with embodiments of the present invention, the present invention is clearly and completely described. In the description of the present invention, it should be noted that, in the embodiments, those not indicating specific conditions, are carried out according to the conditions of normal conditions or manufacturer's suggestions. Reagents used or instruments not indicating manufacturers are conventional products that can be obtained by commercial purchase. In the case of not making special instructions, the parts used in the embodiments of the present invention are all parts by weight.

[0040] Part I: Construction and performance testing of panthenol-L-carnitine supramolecular complex

[0041] The preparation method of panthenol-L-carnitine supramolecule is as follows:

[0042] Accurately weigh panthenol and L-carnitine in a certain ratio, heat to 75-80°C, stir until completely dissolved, cool to room temperature, and let stand.

[0043] The formula is shown in Table 1.

[0044] Table 1 Supramolecular formula

[0045]

[0046]

[0047] The sample of Example 2 was sent for NMR examination, and the results were as follows Figure 5 shown; through Figure 5 It can be seen that: By comparing the NMR spectra of panthenol, carnitine and super-fractionated panthenol, it can be seen that: (1) no new peaks appear, indicating that the interaction between the two does not form new substances. The two groups marked in the box correspond to the three hydroxyl groups of panthenol, and their positions have moved, indicating that there is an obvious interaction between the two, which verifies the formation of supramolecular panthenol.

[0048] Performance Testing

[0049] 1. Skin feel test;

[0050] The samples of the above-mentioned examples and comparative examples were dissolved in water to make the supramolecule concentration be 7 wt %; 10 volunteers were recruited to score each solution containing the sample, with the score ranging from 0 to 5, and the lower the score, the stickier the skin feel.

[0051] The test results are shown in Table 2 below;

[0052] Table 2 Skin feel test results

[0053] Skin feel score Example 1 3.7 Example 2 3.6 Example 3 3.4 Comparative Example 1 3.1 Comparative Example 2 2.9

[0054] 2. Skin repair test

[0055] The test method is:

[0056] Test samples: The samples of the above examples and comparative examples were dissolved in water to make the supramolecular concentration 1wt%;

[0057] Subject information: There are 25 volunteers in total, including 10 males and 15 females, aged between 20 and 35 years old; they are in good health and none of them are highly sensitive; every 5 volunteers are randomly divided into a group and one sample is tested.

[0058] Setting of test area: The arms of volunteers were divided into 4 test areas, one for the forearm and one for the posterior arm, with a test area of ​​3*3cm;

[0059] Establishment of skin barrier damage model: The skin barrier of the test area was damaged by tearing with low-allergenic tape;

[0060] Product use: Apply the test sample to 2 test areas of the same arm (one on the forearm and one on the back arm) at a rate of 0.5 g / test area, and the other arm serves as a blank control;

[0061] Data testing: 2 hours after the sample was used, the laboratory staff used the Tewameter TM Hex transepidermal water loss tester to test the test area;

[0062] Average transepidermal water loss change rate = (after use - before use) * 100 / before use;

[0063] The test results can be seen in Table 3 below;

[0064] Table 3 Average transepidermal water loss rate test results

[0065]

[0066] It can be seen from the test results in Tables 2 and 3 above that the use of panthenol-L-carnitine to form a supramolecule can significantly improve the stickiness of panthenol. At the same time, compared with other complexes that can form a supramolecule with panthenol, it can repair the skin barrier more quickly.

[0067] Part II Construction and performance testing of panthenol-L-carnitine-oligofructose supramolecular complex

[0068] The preparation method of panthenol-L-carnitine supramolecule is as follows:

[0069] Accurately weigh panthenol, L-carnitine, oligofructose or sodium hyaluronate in a certain proportion, heat to 75-80 degrees, stir to dissolve completely, cool to room temperature and let stand.

[0070] The formula is shown in Table 4.

[0071] Table 4 Supramolecular formula

[0072] Panthenol L-Carnitine Betaine Sodium Citrate Fructo-oligosaccharides Sodium Hyaluronate Example 4 70 30 0 0 3 0 Example 5 75 25 0 0 5 0 Example 6 80 20 0 0 6 0 Comparative Example 3 75 25 0 0 0 5 Comparative Example 4 75 0 25 0 5 0 Comparative Example 5 75 0 0 25 5 0

[0073] The sodium hyaluronate used in Comparative Example 3 is low molecular weight sodium hyaluronate with a molecular weight of 10 to 500 KDa.

[0074] Performance Testing

[0075] 1. Skin feel test;

[0076] The samples of the above-mentioned examples and comparative examples were dissolved in water to make the supramolecule concentration be 7 wt %; 10 volunteers were recruited to score each solution containing the sample, with the score ranging from 0 to 5, and the lower the score, the stickier the skin feel.

[0077] The test results are shown in Table 5 below;

[0078] Table 5 Skin feel test results

[0079] Skin feel score Example 4 4.3 Example 5 4.5 Example 6 4.3 Comparative Example 3 3.2 Comparative Example 4 3.1 Comparative Example 5 3.1

[0080] It can be seen from Examples 4 to 5 above that the use of low-molecular-weight fructose can further improve the skin feel of panthenol, and volunteers reported that the aqueous solution had a smooth and delicate skin feel without obvious stickiness.

[0081] Compared with Example 2, the skin feel of Comparative Example 3 was not significantly improved, and the skin feel was further reduced. The possible reason is that the low molecular weight hyaluronic acid has a molecular weight distribution of 10 to 500 KDa. Although it has a relatively smooth skin feel, it cannot form an organic supramolecular system with panthenol-L-carnitine, and exists as two separate substances, resulting in a worse skin feel.

[0082] It can be seen from Comparative Examples 4 and 5 that the effect of low molecular weight fructose on improving the skin feel of the panthenol-L-carnitine supramolecular system is unique. Due to the limited experiments of the present invention, it cannot be ruled out that the panthenol-betaine supramolecular system and the panthenol-sodium citrate supramolecular system can produce similar effects to those of this case with other polysaccharides.

[0083] 2. Skin repair test

[0084] The test method is:

[0085] Test samples: The samples of the above examples and comparative examples were dissolved in water to make the supramolecular concentration 1wt%;

[0086] Subject information: There are 30 volunteers in total, including 16 males and 14 females, aged between 20 and 35 years old; they are in good health and none of them are highly sensitive; every 5 volunteers are randomly divided into a group and one sample is tested.

[0087] Setting of test area: The arms of volunteers were divided into 4 test areas, one for the forearm and one for the posterior arm, with a test area of ​​3*3cm;

[0088] Establishment of skin barrier damage model: The skin barrier of the test area was damaged by tearing with low-allergenic tape;

[0089] Product use: Apply the test sample to 2 test areas of the same arm (one on the forearm and one on the back arm) at a rate of 0.5 g / test area, and the other arm serves as a blank control;

[0090] Data testing: 2 hours after the sample was used, the laboratory staff used the Tewameter TM Hex transepidermal water loss tester to test the test area;

[0091] Average transepidermal water loss change rate = (after use - before use) * 100 / before use;

[0092] The test results can be seen in Table 6 below;

[0093] Table 6 Average transepidermal water loss rate test results

[0094]

[0095]

[0096] It can be seen from the test results in Table 6 above that the use of panthenol-L-carnitine to form a supramolecule and the addition of oligofructose can significantly improve the stickiness of panthenol and further increase the speed of repairing the skin barrier.

[0097] The difference between the blank area and the sample area of ​​Comparative Example 3 is the largest among all cases. The possible reason is that low molecular weight hyaluronic acid has good permeability and skin barrier repair effect, which can effectively improve the skin's transepidermal water loss. This result is mostly due to the use of low molecular weight hyaluronic acid.

[0098] It can be seen from the test results of Comparative Examples 4 and 5, Comparative Examples 1 and Comparative Examples 2 that the use of oligofructose cannot further significantly improve the skin barrier repair effect on the basis of the original effect.

[0099] According to the test results of the first and second parts of the present invention, all volunteers did not show skin tingling or allergy, indicating that the product of the present invention is non-irritating at a concentration below 7wt%, and is non-irritating at a concentration below 1wt% when the skin barrier is damaged.

[0100] In summary, the advantages of the product of the present invention are: by using panthenol and L-carnitine to form a supramolecular compound, and through application functional testing, it is found that it has a better skin feel than other panthenol supramolecular compounds. At the same time, the supramolecular compound has certain antibacterial ability and skin repair ability. By using L-carnitine, the antibacterial ability of panthenol is further improved.

[0101] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that the equivalents falling within the claims be included. All changes in the meaning and scope of the elements are encompassed by the present invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

Claims

1. A supramolecular panthenol composition, characterized in that: It includes the following components by weight: Panthenol 70-80 parts; 20-30 parts of L-carnitine.

2. The supramolecular panthenol composition according to claim 1, characterized in that Also includes: 3-8 parts of oligofructose.

3. The supramolecular panthenol composition according to claim 2, characterized in that It includes the following components by weight: Panthenol 75-80 parts; 20-25 parts of L-carnitine; 4-7 parts of oligofructose.

4. Use of the supramolecular panthenol composition according to any one of claims 1 to 3 in preparing cosmetics.

5. A cosmetic, characterized in that: A supramolecular panthenol composition comprising any one of claims 1 to 3.

6. The cosmetic according to claim 5, characterized in that: The supramolecular panthenol composition contains 0.1-7 wt %.

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