Pet summer-heat-clearing tablet added with summer-heat-resisting traditional Chinese medicine composition and preparation method of pet summer-heat-clearing tablet

Abstract

The invention discloses a pet summer-heat-clearing tablet added with an anti-summer-heat traditional Chinese medicine composition and a preparation method of the pet summer-heat-clearing tablet. The summer heat clearing tablet for pets comprises a base material and a traditional Chinese medicine composition, and the mass part ratio of the traditional Chinese medicine composition to the base material is (133-300): (571-1123); wherein the traditional Chinese medicine composition is prepared from the following components in parts by mass: 3 to 10 parts of herba menthae extract, 80 to 150 parts of flos chrysanthemi indici extract, 20 to 80 parts of herba pogostemonis extract and 30 to 60 parts of herba elsholtziae extract. The traditional Chinese medicine composition in the summer heat clearing tablet for the pets can effectively relieve heat stress of the pets and the phenomena of inappetence, fatigue, even vomiting and the like caused by summer heat, and promote the pets to quickly return to normal; meanwhile, the traditional Chinese medicine composition is extracted in a pure natural manner, is relatively easy to degrade and discharge in the pet body, does not generate medicine residues, and is beneficial to protecting the health of the pet.

Description

Technical Field

[0001] The invention belongs to the field of pet products, and particularly relates to a pet summer heat-clearing tablet added with an anti-summer heat Chinese medicine composition and a preparation method thereof. Background Art

[0002] As our human companions, pets are a source of happiness and healthy life. Communication with pets can make the lives of the elderly more fulfilling, help young people reduce stress in life and improve work efficiency, and cultivate children's sense of responsibility and social interaction skills. With more and more families keeping pets, pet health is gradually being paid attention to by pet owners.

[0003] When the temperature is high in the summer (especially in extreme heat), pets such as dogs and cats may suffer from heat stroke, diarrhea, summer heat colds, etc. When encountering such situations, the main means currently is to rely on the pet's self-regulation to recover. During this period, the pet is often accompanied by loss of appetite, fatigue, and heavy breathing, which affects the pet's health.

[0004] When pet owners find that their pets have heatstroke, they will take them to the pet hospital for medication. However, the pets may not cooperate and cannot take medication, and it also costs a lot of money. With the current surge in the number of pets, it is necessary to find a more suitable and economical method to prevent pets from getting heatstroke in high temperature environments and to alleviate the impact of heat on the body when pets get heatstroke.

[0005] As the pet market gradually expands, there are some existing technologies that alleviate the phenomenon of summer heat by adding some drugs to pets' food and drinking water. However, most of the drugs currently used in clinical practice are hormones, which have poor therapeutic effects and obvious side effects.

[0006] Traditional Chinese medicine has a good application in relieving summer heat. It is relatively easy to degrade and excrete in the body, does not produce drug residues, and has good preventive and health care effects. How to reasonably apply traditional Chinese medicine and its composition to the pet field to relieve summer heat is a problem that needs to be solved in this field. Summary of the invention

[0007] The main purpose of the invention is to provide a pet summer heat-clearing tablet added with an anti-summer heat Chinese medicine composition.

[0008] Another object of the present invention is to provide a method for preparing a pet summer heat-clearing tablet added with an anti-summer heat Chinese medicine composition.

[0009] In order to achieve the above-mentioned main purpose, the present invention provides a pet summer-heat-relief tablet added with an anti-heat Chinese medicine composition, the pet summer-heat-relief tablet comprises a base material and a Chinese medicine composition, the weight ratio of the Chinese medicine composition to the base material is (133-300): (571-1123); wherein the Chinese medicine composition comprises the following components in weight parts: 3-10 parts of peppermint extract, 80-150 parts of wild chrysanthemum extract, 20-80 parts of Patchouli extract, and 30-60 parts of Elsholtzia extract.

[0010] Optionally, the Chinese medicine composition comprises the following components in parts by weight: 5-8 parts of peppermint extract, 100-120 parts of wild chrysanthemum extract, 30-60 parts of patchouli extract, and 35-55 parts of elsholtzia extract.

[0011] Optionally, the Chinese medicine composition includes the following components in parts by weight: 5 parts of peppermint extract, 100 parts of wild chrysanthemum extract, 60 parts of patchouli extract, and 35 parts of elsholtzia extract.

[0012] Optionally, the pet summer heat-relief tablets are effervescent tablets, and the base material includes the following components in the following weight proportions: 150-300 parts of sodium bicarbonate, 150-300 parts of L-malic acid, 180-280 parts of sorbitol, 15-60 parts of tablet lubricants, 15-60 parts of taste masking agents, 60-120 parts of sodium carboxymethyl cellulose, and 1-3 parts of glidants.

[0013] To achieve the above another object, the present invention provides a method for preparing a pet summer heat-clearing tablet added with a Chinese medicine composition for relieving summer heat, which comprises the following steps:

[0014] (1) Prepare the base material of pet summer heat-clearing tablets;

[0015] (2) preparing the components of the Chinese medicine composition, and fully mixing the components of the Chinese medicine composition to obtain the Chinese medicine composition;

[0016] (3) adding a portion of the Chinese medicine composition of step (2) into the container of a blender;

[0017] (4) adding sorbitol, tablet lubricant, taste masking agent and sodium carboxymethyl cellulose in the base material into the container of a blender and mixing thoroughly;

[0018] (5) adding the remaining portion of the Chinese medicine composition of step (2) into the container of a blender and mixing them uniformly;

[0019] (6) Add the flow aid, sodium bicarbonate and L-malic acid in the base material into the container of the blender and mix thoroughly;

[0020] (7) sieving;

[0021] (8) tabletting to obtain pet summer heat-clearing tablets.

[0022] Optionally, the Chinese medicine composition in step (2) is obtained by the following method:

[0023] (2.1) Mint extract: Take the dried stems and leaves of the plant raw material mint, sort, wash, and crush them, and then use an organic solvent to heat and reflux to extract, recover the organic solvent from the obtained extract, and spray powder to obtain the mint extract;

[0024] (2.2) Wild chrysanthemum extract: The dried flowers of wild chrysanthemum, a plant raw material, are selected, cleaned, crushed, and then boiled in water for extraction. The obtained extract is concentrated and powdered to obtain the wild chrysanthemum extract;

[0025] (2.3) Patchouli extract: The dried stems and leaves of the plant raw material Patchouli are selected, cleaned, crushed, and then boiled in water for extraction. The obtained extract is concentrated and powdered to obtain Patchouli extract;

[0026] (2.4) Elsholtzia extract: dry stems and leaves of the plant raw material Elsholtzia are selected, washed, crushed, and then boiled in water for extraction. The obtained extract is concentrated and powdered to obtain the Elsholtzia extract;

[0027] (2.5) The peppermint extract of step (2.1), the wild chrysanthemum extract of step (2.2), the patchouli extract of step (2.3) and the Elsholtzia ciliata extract of step (2.4) are mixed in amounts to obtain a Chinese medicine composition.

[0028] Optionally, the organic solvent used in step (2.1) is 60% ethanol, the ratio of the plant raw material mint to the organic solvent is 1 g: 5-10 mL, the heating temperature is 60-90° C., each extraction time is 0.5-1 h, and the number of extractions is 1-3 times.

[0029] Optionally, the water used in step (2.2) is deionized water, the ratio of the plant raw material wild chrysanthemum to water is 1g:8-10mL, the extraction time is 0.5-1h each time, the number of extractions is 1-2 times, and the auxiliary material for powder spraying is a combination of maltodextrin, micropowder silica gel, and microcrystalline cellulose. The proportion of the auxiliary material for powder spraying is 5%-20% compared to the extract.

[0030] Optionally, the water used in step (2.3) is deionized water, the ratio of the plant raw material patchouli to water is 1 g: 7-10 mL, the extraction time is 0.5-1 h each time, the number of extractions is 1-2 times, and the powder spraying auxiliary material is a combination of maltodextrin, micropowder silica gel, and microcrystalline cellulose, and the proportion of the powder spraying auxiliary material to the extract is 5%-20%.

[0031] Optionally, the water used in step (2.4) is deionized water, the ratio of the plant raw material Elsholtzia to water is 1 g: 6-8 mL, the extraction time is 0.5-1.5 h each time, the number of extractions is 1-2 times, and the powder spraying auxiliary material is a combination of maltodextrin, micropowder silica gel, and microcrystalline cellulose, and the proportion of the powder spraying auxiliary material to the extract is 5%-20%.

[0032] The present invention has the following beneficial effects:

[0033] The pet summer heat-clearing tablets of the present invention contain a Chinese medicine composition whose main components are peppermint extract, wild chrysanthemum extract, patchouli extract and elsholtzia extract. The Chinese medicine composition can effectively relieve the pet's heat stress and the phenomena such as loss of appetite, fatigue and even vomiting caused by the summer heat, and promote the pet to quickly recover to normal; at the same time, the Chinese medicine composition is extracted in a purely natural way, and is relatively easy to degrade and excrete in the pet's body, and will not produce drug residues, which is beneficial to protecting the health of the pet.

[0034] The pet summer heat-clearing tablets of the present invention are specifically effervescent tablets, which can be absorbed by the pets during the pets' drinking process, thus facilitating the pets' rapid acquisition of effective ingredients.

[0035] In order to more clearly illustrate the purpose, technical solutions and advantages of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 This is a schematic diagram of the components of the pet summer heat-clearing tablets after they are mixed before tableting;

[0037] Figure 2 It is a schematic diagram of the tableting process of pet summer heat-clearing tablets;

[0038] Figure 3 is a schematic diagram of the rabbit liver oxidation index in the test example;

[0039] Figure 4 is a schematic diagram of the rabbit serum enzyme in the test example;

[0040] Figure 5 It is a schematic diagram of the blood routine indicators of rabbits in the experimental example. DETAILED DESCRIPTION

[0041] In the following description, many specific details are explained in conjunction with the embodiments to facilitate a full understanding of the present invention. However, it should be understood that the following embodiments and detailed descriptions are only for illustrative purposes and do not limit the scope of protection of the present invention.

[0042] The embodiment of the present invention discloses a pet summer-heat-relief tablet added with an anti-heat-relief Chinese medicine composition. The pet summer-heat-relief tablet comprises a base material and the Chinese medicine composition, wherein the weight ratio of the Chinese medicine composition to the base material is (133-300): (571-1123), wherein the Chinese medicine composition comprises the following components in weight parts: 3-10 parts of peppermint extract, 80-150 parts of wild chrysanthemum extract, 20-80 parts of patchouli extract, and 30-60 parts of elsholtzia extract.

[0043] Preferably, the Chinese medicine composition comprises the following components in parts by weight: 5-8 parts of peppermint extract, 100-120 parts of wild chrysanthemum extract, 30-60 parts of patchouli extract, and 35-55 parts of elsholtzia extract.

[0044] Among them, the pet summer heat-clearing tablets of the embodiment are specifically effervescent tablets, and the base material includes the following components in proportion by mass: 150-300 parts of sodium bicarbonate, 150-300 parts of L-malic acid, 180-280 parts of sorbitol, 15-60 parts of tablet lubricants, 15-60 parts of taste masking agents, 60-120 parts of sodium carboxymethyl cellulose, and 1-3 parts of glidants. Specifically, the tablet lubricant is polyethylene glycol 6000, the taste masking agent is β-cyclodextrin, and the glidant is magnesium stearate.

[0045] The present invention provides the following experimental examples 1-6. The pet summer heat-clearing tablets in experimental examples 1-6 are all effervescent tablets, and their components are shown in the following table:

[0046] Experimental Example 1 Experimental Example 2 Experimental Example 3 Experimental Example 4 Experimental Example 5 Experimental Example 6 Peppermint Extract 5 servings 8 servings 5 servings 6 servings 3 servings 4 servings Wild Chrysanthemum Extract 100 copies 120 servings 100 copies 150 copies 80 servings 130 copies Patchouli Extract 40 servings 32 servings 60 servings 50 servings 20 servings 70 servings Elsholtzia Extract 55 servings 40 servings 35 servings 30 servings 30 servings 45 servings Sodium bicarbonate 200 copies 200 copies 250 copies 300 copies 150 copies 180 copies L-Malic Acid 200 copies 200 copies 150 copies 300 copies 150 copies 240 copies Sorbitol 200 copies 250 copies 220 copies 280 copies 180 copies 200 copies Polyethylene glycol 6000 50 servings 50 servings 30 servings 60 servings 15 servings 40 servings β-Cyclodextrin 50 servings 20 servings 50 servings 60 servings 15 servings 40 servings Sodium Carboxymethyl Cellulose 100 copies 80 servings 100 copies 120 servings 60 servings 70 servings Magnesium Stearate 1 serving 1 serving 1 serving 2 servings 1 serving 2 servings

[0047] Each of the above experimental examples can be prepared by the following preparation method. The preparation method includes the following steps:

[0048] (1) preparing basic materials for pet summer heat-clearing tablets, wherein the basic materials can be obtained by purchasing on the market;

[0049] (2) preparing the components of the Chinese medicine composition, and fully mixing the components of the Chinese medicine composition to obtain the Chinese medicine composition;

[0050] Wherein, the Chinese medicine composition in step (2) can be obtained by the following method:

[0051] (2.1) Mint extract: dry stems and leaves of the plant raw material mint are selected, cleaned, crushed, and then extracted by heating and refluxing with an organic solvent. The organic solvent is recovered from the obtained extract, and the mint extract is obtained by spraying with powder. The organic solvent used is preferably 60% ethanol, the ratio of the plant raw material mint to the organic solvent is 1g:5-10mL, the heating temperature is 60-90°C, the extraction time is 0.5-1h each time, and the number of extractions is 1-3 times.

[0052] Preferably, the ratio of the plant raw material mint to the organic solvent is 1 g:8 mL, the heating temperature is 70° C., each extraction time is 0.5 h, and the extraction times are 2 times.

[0053] (2.2) Wild chrysanthemum extract: The dried flowers of the plant raw material wild chrysanthemum are selected, cleaned, crushed, and then boiled in water for extraction. The obtained extract is concentrated and sprayed with powder to obtain the wild chrysanthemum extract; the water used is deionized water, the ratio of the plant raw material wild chrysanthemum to water is 1g:8-10mL, the extraction time is 0.5-1h each time, the number of extractions is 1-2 times, and the auxiliary material for spraying with powder is a mixture of maltodextrin, micro-powder silica gel and microcrystalline cellulose.

[0054] Preferably, the ratio of wild chrysanthemum to water is 1g:10mL, the extraction time is 1h each time, and the number of extractions is 2 times; the proportion of the powdered auxiliary materials used is 5%-20% compared to the extract, for example, if the weight of the extract powder is 1000g, the weight of the auxiliary materials is 50-200g. Furthermore, the proportion of maltodextrin in the powdered auxiliary materials used is 3%-10%, the proportion of micropowdered silica gel is 1%-5%, and the proportion of microcrystalline cellulose is 1%-5%. The proportion here refers to the proportion of the powdered auxiliary materials compared to the extract.

[0055] (2.3) Patchouli extract: The dried stems and leaves of the plant material Patchouli are selected, cleaned, crushed, and then boiled in water for extraction. The obtained extract is concentrated and powdered to obtain Patchouli extract; the water used is deionized water, the ratio of the plant material Patchouli to water is 1g:8-10mL, the extraction time is 0.5-1h each time, the number of extractions is 1-2 times, and the auxiliary material for powdering is a mixture of maltodextrin, micro-powder silica gel and microcrystalline cellulose.

[0056] Similarly, the ratio of the plant raw material patchouli to water is 1g:10mL, the extraction time is 1h each time, and the extraction times are 2 times; among them, the powdered excipients used include maltodextrin at 3%-10%, micro-powdered silica gel at 1%-5%, and microcrystalline cellulose at 1%-5%. The proportion here refers to the proportion of the powdered excipients compared to the extract.

[0057] (2.4) Elsholtzia extract: The dried stems and leaves of the plant raw material Elsholtzia are selected, cleaned, crushed, and then boiled in water for extraction. The obtained extract is concentrated and sprayed with powder to obtain the Elsholtzia extract; wherein the water used is deionized water, the ratio of the plant raw material Elsholtzia to water is 1g:6-8mL, the extraction time is 0.5-1.5h each time, the number of extractions is 1-2 times, and the auxiliary material for spraying with powder is a mixture of maltodextrin, micro-powder silica gel and microcrystalline cellulose.

[0058] Similarly, the ratio of the plant raw material Elsholtzia ciliata to water is 1g:7mL, the extraction time is 1.5h each time, and the extraction times are 2 times; among them, the powdered excipients used include maltodextrin accounting for 3%-10%, micro-powdered silica gel accounting for 1%-5%, and microcrystalline cellulose accounting for 1%-5%. The proportion here refers to the proportion of the powdered excipients compared to the extract.

[0059] The above-mentioned wild chrysanthemum extract, patchouli extract, and elsholtzia extract have similar processing processes before powder spraying, and can be extracted using the same process equipment. The exemplary extraction and concentration process is as follows:

[0060] 1) Put the plant material into an extraction tank, add 8 times the mass of water, extract at 90°C for 1 hour, and obtain the filtrate and residue after filtering;

[0061] 2) Add 6 times the mass of water to the residue, continue extraction at 70°C for 1 hour, and obtain the filtrate after filtration;

[0062] 3) Pour the filtrates from the above two times into the concentration tank;

[0063] 4) Concentrating at 60°C-70°C with a concentration ratio of 1:1.2;

[0064] 5) Add auxiliary materials to the concentrated extract and stir evenly, spray powder at an inlet air temperature of 150°C to 165°C, an outlet air temperature of 65°C to 85°C, an inner tower temperature of 75°C to 90°C, and a negative pressure of 10Pa to 18Pa. The sprayed powder is sieved to obtain the extract powder.

[0065] (3) adding a portion (e.g., 50%) of the Chinese medicine composition into a container of a blender;

[0066] (4) adding sorbitol, polyethylene glycol 6000, β-cyclodextrin and sodium carboxymethyl cellulose in the base material into the container of a blender and mixing thoroughly;

[0067] (5) adding the remaining portion of the Chinese medicine composition into the container of the blender and mixing uniformly;

[0068] (6) Add magnesium stearate, sodium bicarbonate and L-malic acid in the base material into the container of a blender and mix thoroughly. Figure 1 As shown;

[0069] (7) sieving;

[0070] (8) tableting to obtain a pet summer heat-clearing tablet such as Figure 2 shown.

[0071] The mixing process of the components of the pet summer heat-clearing tablets in the embodiment is carried out by a "sandwich" mixing method, which can make the Chinese medicine composition and the base material fully and evenly mixed. The most important acid and alkali source in the effervescent tablet is added at the last stage of the "sandwich", which can effectively prevent the acid-base neutralization reaction after the Chinese medicine composition absorbs moisture during the previous mixing process, thereby avoiding material waste; magnesium stearate as a flow aid has a good anti-adhesion effect, which makes the acid and alkali sources better separated in the mixer, and also adds a layer of "protective cover" to prevent acid-base neutralization reaction.

[0072] Rabbit heat exposure experiment

[0073] 1. Experimental Animals

[0074] Fifty adult male rabbits were purchased from Henan Kangda Experimental Animal Co., Ltd., weighing 1.5-2.0 kg.

[0075] 2. Experimental Grouping

[0076] The rabbits were randomly divided into five groups: blank group (n=10), model group (n=10), experimental low-dose group (n=10), experimental high-dose group (n=10), and positive control group (n=10).

[0077] The blank group was raised normally in a room temperature environment with free access to water;

[0078] The model group (n=10) was raised in high temperature exposure with free access to water;

[0079] The low-dose group was exposed to high temperature and fed with 1g / tablet of effervescent tablets in 200ml of water, with an intragastric dose of 3mL / kg body weight. The group was allowed to drink water freely at other times.

[0080] The high-dose group was exposed to high temperature and fed with 1g / tablet of effervescent tablets in 100ml of water, with an intragastric dose of 3mL / kg body weight. The group was allowed to drink water freely at other times.

[0081] The positive control group was exposed to high temperature and given Taiji Huoxiang Zhengqi Liquid (purchased from Zhang Zhongjing Pharmacy) at a gavage dose of 3 mL / kg. The mice were allowed to drink water freely at other times.

[0082] Rabbit diets were purchased from Shandong Yavini Feed Factory.

[0083] The effervescent tablets selected for the experiment were the pet summer-heat-clearing tablets of Experimental Example 3.

[0084] 3. Experimental Procedure

[0085] 3.1 High temperature exposure environment

[0086] The relative humidity of the high temperature environment was 75%±5%, and the infrared lamp was used as the heat radiation source. During the heat radiation period, the doors and windows were closed to maintain the high temperature for 2 hours. When the body temperature of the heated rabbits reached 41±2℃, the heat radiation was stopped. After the heat radiation was stopped, each group of animals continued to be observed.

[0087] The experimental period was one week.

[0088] During the experiment, body temperature, heart rate, and respiratory rate were measured before and after heat exposure, and the amount of food and water consumed was recorded at 6 pm every day.

[0089] 3.2 Collection of materials

[0090] Blood was collected from the ear vein of the experimental rabbits. A portion of the fresh blood was used to determine the blood routine test, and a portion was centrifuged (3000r / min, 10min) to obtain serum, which was labeled and stored at -20°C for later use. The rabbits were killed after their livers were collected.

[0091] 3.3 Index determination

[0092] 3.3.1 Determination of oxidation indexes in liver

[0093] The following steps were all performed on ice.

[0094] The livers of each group were weighed, chopped, and added with 10 times the mass of normal saline. The liver tissue homogenate was prepared by freezing tissue grinder, and the supernatant was obtained by freezing centrifugation at 3000r / min for enzyme-linked immunosorbent assay (ELISA) to detect the antioxidant indicators total superoxide dismutase (T-SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px).

[0095] The kit was purchased from Nanjing Jiancheng Bioengineering Institute Co., Ltd.

[0096] 3.3.2 Serum enzyme assay

[0097] The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN) and creatinine (CREA) in each heat exposure group were measured using an automatic biochemical analyzer.

[0098] 3.3.3 Routine blood test

[0099] Fresh blood was collected and routine blood tests including red blood cells (RBC), white blood cells (WBC), neutrophils (NEU) and platelets (PLT) were performed using a Mindray three-classification blood cell analyzer.

[0100] 4. Experimental Results

[0101] 4.1 Results of liver oxidation index determination

[0102] like Figure 3As shown, compared with the model group, the levels of T-SOD and GSH-Px in the liver of the blank group, high-dose experimental group and positive control group were significantly increased (P<0.05), and the MDA content was decreased (P<0.05). In the low-dose experimental group, the T-SOD level was increased but not significantly, the GSH-Px level had no significant change, and the MDA level was increased (P<0.05).

[0103] 4.2 Serum enzyme test results

[0104] Depend on Figure 4 It can be seen that the model group had the highest serum AST, ALT, BUN and CREA levels. Compared with the model group, the positive control group and high-dose experimental group had significantly lower serum AST, ALT, BUN and CREA levels (P<0.05), the low-dose experimental group had lower AST, ALT and BUN levels, but no significant difference, and the CREA level was significantly reduced (P<0.05).

[0105] 4.3 Results of routine blood tests

[0106] Depend on Figure 5 It can be seen that the number of white blood cells and neutrophils in the model group was the highest. Compared with the blank group, the number of red blood cells in the model group decreased, and the number of platelets increased, but not significantly. Compared with the model group, the number of white blood cells and neutrophils in the positive control group and the high- and low-dose experimental groups was significantly decreased (P<0.05), and the number of red blood cells and platelets was not obvious.

[0107] Heat stress is a non-specific reaction of the animal body to the external high temperature environment, involving multiple systems such as respiration, blood circulation, digestion, endocrine and immunity. Routine blood test is one of the most basic indicators of blood system examination, which can reflect the body's blood system diseases and infectious diseases. Through the above-mentioned heat exposure experiment, it was found that under acute heat stress environment, the number of white blood cells and neutrophils in rabbits increased significantly. It may be that the body secretes more hormones under stress state and the blood flow speed is accelerated, which prompts the white blood cells adhering to the edge pool of blood vessels to enter the circulation pool, thereby causing the number of white blood cells to increase in a short period of time.

[0108] Through the above heat exposure experiment, it was found that the pet summer heat-clearing tablets of the embodiment of the present invention can reduce the number of white blood cells in the blood of mice under heat stress, which may be related to the anti-inflammatory components contained in the components. The phenolic components in Elsholtzia and Patchouli, the flavonoids in Chrysanthemum indica, and the terpenes in mint all have anti-inflammatory activity, thereby inhibiting the entry of white blood cells into the circulation pool.

[0109] Serum biochemical indicators can determine whether the body's tissue and organ functions are normal, and are of great significance for the diagnosis of animal diseases. Among them, AST and ALT are important indicators reflecting liver function and are often used as the basis for the diagnosis of liver damage. In the above-mentioned heat exposure experiment, the serum AST and ALT levels of heat-stressed rabbits increased significantly, indicating that heat stress caused certain damage to the liver, and pet summer heat-clearing tablets can alleviate this phenomenon. Crea and BUN are important diagnostic indicators of kidney function. Serum Crea and BUN are positively correlated with kidney function damage, which has positive significance in the diagnosis of kidney function damage. When the body is in a state of heat stress, blood flow speeds up, and the amount of blood passing through the kidneys per unit time increases. At this time, the metabolic products in the body are also higher than normal levels, posing a great threat to the kidneys.

[0110] Oxidative damage is one of the main ways that heat stress causes harm to the body. During heat stress, the body produces a large number of free radicals. The accumulation of these free radicals and their metabolites in the body can damage cell membranes, proteins, DNA and other structures, causing damage to the body. MDA is one of the products of free radicals acting on lipids to produce peroxidation reactions. It has cytotoxicity. Its content in the body is an important parameter reflecting the body's antioxidant capacity and can also indirectly reflect the degree of tissue peroxidation damage. In the above-mentioned heat exposure experiment, the MDA content in the liver of heat-stressed rabbits increased significantly. T-SOD is the body's first line of defense against free radicals. It is known as a free radical scavenger and can quickly remove free radicals produced in the liver and repair damaged liver cells. GSH-Px is an important material basis for the body to remove lipid peroxides and block the generation of free radicals. Elsholtzia and peppermint essential oils have strong antioxidant functions, and the polyphenols of Patchouli have significant antioxidant functions.

[0111] Although the present invention has been described above through embodiments, the above embodiments are only used to exemplarily describe the feasible implementation schemes of the present invention, and are not used to limit the protection scope of the present invention. Any equivalent substitutions or changes made by those skilled in the art in accordance with the present invention should also be covered by the protection scope defined by the claims of the present invention.

Claims

1. A pet summer heat-clearing tablet added with an anti-heat Chinese medicine composition, characterized in that: The pet summer heat-clearing tablets include a base material and a traditional Chinese medicine composition, wherein the weight ratio of the traditional Chinese medicine composition to the base material is (133-300): (571-1123); wherein the traditional Chinese medicine composition includes the following components in weight parts: 3-10 parts of peppermint extract, 80-150 parts of wild chrysanthemum extract, 20-80 parts of patchouli extract, and 30-60 parts of elsholtzia extract.

2. The pet summer heat-clearing tablets added with the anti-heat Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition comprises the following components in parts by weight: 5-8 parts of peppermint extract, 100-120 parts of wild chrysanthemum extract, 30-60 parts of patchouli extract and 35-55 parts of elsholtzia extract.

3. The pet summer heat-clearing tablets added with the anti-heat Chinese medicine composition according to claim 2, characterized in that: The traditional Chinese medicine composition comprises the following components in parts by weight: 5 parts of peppermint extract, 100 parts of wild chrysanthemum extract, 60 parts of patchouli extract and 35 parts of elsholtzia extract.

4. The pet summer heat-clearing tablets added with the anti-heat Chinese medicine composition according to claim 1, characterized in that: The pet summer heat-clearing tablet is an effervescent tablet, and the base material comprises the following components in proportion by weight: 150-300 parts of sodium bicarbonate, 150-300 parts of L-malic acid, 180-280 parts of sorbitol, 15-60 parts of tablet lubricants, 15-60 parts of taste masking agents, 60-120 parts of sodium carboxymethyl cellulose, and 1-3 parts of glidants.

5. A method for preparing a pet summer heat-relief tablet added with a Chinese medicine composition for relieving summer heat as claimed in any one of claims 1 to 4, characterized in that The following steps are involved: (1) Prepare the base material of pet summer heat-clearing tablets; (2) preparing the components of the Chinese medicine composition, and fully mixing the components of the Chinese medicine composition to obtain the Chinese medicine composition; (3) adding a portion of the Chinese medicine composition described in step (2) into the container of a blender; (4) adding sorbitol, tablet lubricant, taste masking agent and sodium carboxymethyl cellulose in the base material into the container of a blender and mixing thoroughly; (5) adding the remaining portion of the Chinese medicine composition of step (2) into the container of a blender and mixing them uniformly; (6) Add the flow aid, sodium bicarbonate and L-malic acid in the base material into the container of the blender and mix thoroughly; (7) sieving; (8) tabletting to obtain pet summer heat-clearing tablets.

6. The method for preparing the summer heat-clearing effervescent tablet for pets according to claim 5, characterized in that: The Chinese medicine composition in step (2) is obtained by the following method: (2.1) Mint extract: Take the dried stems and leaves of the plant raw material mint, sort, wash, and crush them, and then use an organic solvent to heat and reflux to extract, recover the organic solvent from the obtained extract, and spray powder to obtain the mint extract; (2.2) Wild chrysanthemum extract: The dried flowers of wild chrysanthemum, a plant raw material, are selected, cleaned, crushed, and then boiled in water for extraction. The obtained extract is concentrated and powdered to obtain the wild chrysanthemum extract; (2.3) Patchouli extract: The dried stems and leaves of the plant raw material Patchouli are selected, cleaned, crushed, and then boiled in water for extraction. The obtained extract is concentrated and powdered to obtain Patchouli extract; (2.4) Elsholtzia extract: dry stems and leaves of the plant raw material Elsholtzia are selected, washed, crushed, and then boiled in water for extraction. The obtained extract is concentrated and powdered to obtain the Elsholtzia extract; (2.5) The peppermint extract described in step (2.1), the wild chrysanthemum extract described in step (2.2), the patchouli extract described in step (2.3) and the Elsholtzia ciliata extract described in step (2.4) are mixed in amounts to obtain a Chinese medicine composition.

7. The method for preparing the summer heat-clearing effervescent tablet for pets according to claim 6, characterized in that: The organic solvent used in step (2.1) is 60% ethanol, the ratio of plant raw material mint to organic solvent is 1g:5-10mL, the heating temperature is 60-90°C, each extraction time is 0.5-1h, and the number of extractions is 1-3 times.

8. The method for preparing the summer heat-clearing effervescent tablet for pets according to claim 6, characterized in that: The water used in step (2.2) is deionized water, the ratio of the plant raw material wild chrysanthemum to water is 1g:8-10mL, the extraction time is 0.5-1h each time, the number of extractions is 1-2 times, and the auxiliary material for powder spraying is a combination of maltodextrin, micropowder silica gel, and microcrystalline cellulose. The proportion of the auxiliary material for powder spraying is 5%-20% compared to the extract.

9. The method for preparing the summer heat-clearing effervescent tablet for pets according to claim 6, characterized in that: The water used in step (2.3) is deionized water, the ratio of plant raw material patchouli to water is 1g:7-10mL, each extraction time is 0.5-1h, the number of extractions is 1-2 times, and the powder spraying auxiliary material is a combination of maltodextrin, micropowder silica gel, and microcrystalline cellulose. The proportion of the powder spraying auxiliary material to the extract is 5%-20%.

10. The method for preparing the summer heat-clearing effervescent tablet for pets according to claim 6, characterized in that: The water used in step (2.4) is deionized water, the ratio of the plant raw material Elsholtzia to water is 1g:6-8mL, the extraction time is 0.5-1.5h each time, the number of extractions is 1-2 times, and the powder spraying auxiliary material is a combination of maltodextrin, micropowder silica gel, and microcrystalline cellulose. The proportion of the powder spraying auxiliary material to the extract is 5%-20%.

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