Burn patch for skin wound treatment and preparation method thereof

Abstract

The invention relates to the technical field of burn patches, in particular to a burn patch for skin wound treatment and a preparation method thereof.The method comprises the steps that a stirrer is used for dissolving active ingredients and collagen into a solvent to output a mixed solution, silica gel and nylon textile cloth are bonded to output an adhesive film patch, and the adhesive film patch is obtained; coating the mixed solution on one side of the nylon textile cloth of the adhesive film paste; the hot air circulating oven is used for drying the adhesive film paste coated with the mixed solution, a cutting machine is used for cutting the dried adhesive film paste, and the silica gel side of the cut adhesive film paste is punched to output the burn paste; determining the preparation stability of the burn patch based on the variance of the concentration of the mixed solution; if the preparation stability does not meet the requirement, adjusting the rotating speed of a stirring motor of a stirrer; and if the forming effectiveness does not meet the requirement, the cutter feeding amount of the cutting machine is adjusted. The preparation stability of the burn patch is improved.

Description

Technical Field

[0001] The invention relates to the technical field of burn patches, and in particular to a burn patch for treating skin wounds and a preparation method thereof. Background Art

[0002] In the prior art, the outermost layer of human skin is the epidermis of the human body, which is approximately 75 to 260 microns thick. Once burned or injured, such as by friction or contact with chemical active ingredients, the epidermis of the human body will fall off, resulting in painful wounds.

[0003] Artificial epidermal replacement membrane is a medical device for treating such wounds. It is a fully synthetic product with only three main components: silicone, nylon textile fabric, and collagen. Its purpose is to temporarily replace the lost epidermis of a person. First, it makes the human body feel that the epidermis is still there and reduces inflammation. By combining with the wound, it does not need to be replaced during the healing process until the wound heals and falls off naturally. Artificial epidermal replacement patch with appropriate application medical procedures can accelerate the healing of patients' wounds. It also brings comfort and reduces pain because it replicates the texture and expansion of human skin. After the patch is applied, it does not need to be replaced during the healing process of the wound unless the wound has an emergency such as infection, severe inflammation, etc., until the wound heals and falls off by itself. This is unlike ordinary treatments, which require repeated replacement of cotton / dressings covering the wound. This repeated pulling of the wound will lead to slow healing of the wound and also cause pain. Using a suitable epidermal replacement patch can save the workload of medical staff, patients can be discharged earlier, reduce the infection rate of patients' wounds, etc., and ultimately reduce the economic burden of trauma / burns. The overall structure of artificial epidermal replacement membranes is mostly a three-layer product. It mainly needs to be temporarily combined with the human body, so the thickness, texture, elasticity, and stretchability are similar to real human epidermis. The outermost layer is a layer of silicone, whose main function is to control the contact of the wound with the outside to prevent bacterial infection. Nylon textile fabric is combined under the silicone layer. The textile is to give the nylon fabric a four-way expansion ability, and also to combine with the serum of the wound, so that the entire dressing sticks to the human body. The purpose of nylon thread is also to guide liquid, to guide the liquid of the wound to the holes punched in the silicone, and overflow / evaporate. The nylon textile fabric will be sprayed with a layer of collagen at a concentration of 10 micrograms per square centimeter. This is to help the textile fabric react with the serum to achieve rapid coagulation, and to achieve healing with the wound through blood coagulation in the textile fabric.

[0004] The first artificial epidermal replacement membrane approved on the market was Biobrane (No. 4725279) in 1979. The patent has expired. In 2009, a new generation product AWBAT (US20090232878A1) appeared, and in 2019 a new product Permeaderm (WO2020231463A1) was launched.

[0005] To date, the 1979 biobrane has been acquired by Smith & Nephew, and its products are widely used in the EU, the UK, Singapore, the US and other countries. Although there is no patent protection, due to the complex production process, the approval numbers of the EU, US standards and Southeast Asian drug regulatory authorities and the mature medical equipment sales supply chain, there are almost no other imitators except the developer Aubrey Woodroof.

[0006] Chinese patent publication number: CN105617461A discloses a skin patch for treating skin burns and a preparation method thereof, comprising the following steps: obtaining adipose stem cells and allogeneic skin matrix respectively; mixing the adipose stem cells with a collagen solution and inoculating them into the allogeneic skin matrix; wherein the adipose stem cells are derived from the patient with skin burns. It can be seen that the skin patch for treating skin burns and the preparation method thereof have the problem that during the dissolution process of the active ingredient, there is residual accumulation of active ingredients on the inner wall of the mixing container, resulting in poor liquid flow during mixing, thereby causing the preparation stability of the burn patch to decrease. Summary of the invention

[0007] To this end, the present invention provides a burn patch for skin wound treatment and a preparation method thereof, so as to overcome the problem in the prior art that during the dissolution process of the active ingredients, residual accumulation of active ingredients exists on the inner wall of the mixing container, resulting in poor liquid flow during mixing, and further leading to uneven mixing, thereby causing a decrease in the preparation stability of the burn patch.

[0008] To achieve the above-mentioned purpose, the present invention provides a method for preparing a burn patch for treating skin wounds, comprising: extracting collagen from fish by a bio-small molecule recovery method, dissolving effective ingredients and the collagen into a solvent using a stirrer to output a mixed solution, bonding silica gel and nylon textile cloth to output a film patch, and coating the mixed solution on the nylon textile cloth side of the film patch; drying the film patch coated with the mixed solution using a hot air circulation oven, cutting the dried film patch using a cutter, and punching holes on the silica gel side of the cut film patch to output the burn patch; obtaining the concentration of the mixed solution at a plurality of sampling points; determining the preparation stability of the burn patch based on the variance of the concentration of the mixed solution; if the preparation stability does not meet the requirements, adjusting the speed of the stirring motor of the stirrer, or determining the molding effectiveness of the burn patch based on the average roughness at the incision of the burn patch; if the molding effectiveness does not meet the requirements, adjusting the tool feed rate of the cutter, or adjusting the airflow circulation speed in the hot air circulation oven based on the drying rate of the burn patch.

[0009] Furthermore, determining the preparation stability of the burn patch includes: Comparing the variance of the concentration of the mixed solution with a preset first variance; If the variance of the concentration of the mixed solution is greater than the preset first variance, it is determined that the preparation stability of the burn patch does not meet the requirements.

[0010] Furthermore, determining the molding effectiveness of the burn patch includes: Comparing the variance of the concentration of the mixed solution with the preset first variance and the preset second variance respectively; If the variance of the concentration of the mixed solution is greater than the preset first variance and less than or equal to the preset second variance, it is preliminarily determined that the molding effectiveness of the burn patch does not meet the requirements, and whether the molding effectiveness of the burn patch meets the requirements is determined based on the average roughness of the incision of the burn patch.

[0011] Furthermore, the speed of the stirring motor of the stirrer is adjusted, including: Comparing the variance of the concentration of the mixed solution with the preset second variance; If the variance of the concentration of the mixed solution is greater than the preset second variance, the speed of the stirring motor of the stirrer is increased.

[0012] Furthermore, the increase range of the rotation speed of the stirring motor of the stirrer is determined by the difference between the variance of the concentration of the mixed solution and a preset second variance.

[0013] Further, adjusting the feed rate of the cutter of the cutting machine includes: The average roughness of the burn patch incision is compared with the preset first roughness and the preset second roughness respectively; If the average roughness of the burn patch cutout is greater than the preset first roughness, it is determined that the forming effectiveness of the burn patch does not meet the requirements; If the average roughness of the burn patch cutout is greater than the preset first roughness and less than or equal to the preset second roughness, reducing the tool feed rate of the cutting machine; If the average roughness of the burn patch incision is greater than the preset second roughness, it is preliminarily determined that the drying effectiveness of the burn patch does not meet the requirements, and whether the drying effectiveness of the burn patch meets the requirements is determined based on the drying rate of the burn patch.

[0014] Furthermore, the reduction range of the feed rate of the cutter of the cutting machine is determined by the difference between the average roughness at the cut of the burn patch and a preset first roughness.

[0015] Further, the airflow circulation speed in the hot air circulation oven is adjusted, including: Compare the drying rate of the burn patch with the preset drying rate; If the drying rate of the burn patch is less than the preset drying rate, it is determined that the drying effectiveness of the burn patch does not meet the requirements, and the airflow circulation speed in the hot air circulation oven is increased.

[0016] Furthermore, the increase range of the air circulation speed in the hot air circulation oven is determined by the difference between the preset drying rate and the drying rate of the burn patch.

[0017] The present invention also provides a burn patch for treating skin wounds, comprising: silica gel, nylon textile cloth, type I collagen, vitamin C, and glycerol.

[0018] Compared with the prior art, the beneficial effect of the present invention lies in that the method of the present invention adjusts the speed of the stirring motor of the stirrer according to the variance of the concentration of the mixed solution. Since during the dissolution process of the effective ingredient, there is residual accumulation of the effective ingredient on the inner wall of the mixing container, which causes poor liquid flow during mixing, thereby causing uneven mixing. By increasing the speed of the stirring motor of the stirrer, the stirrer can provide a greater driving force to push the liquid to flow faster, which helps to overcome the flow resistance caused by the accumulation of residual substances, so that the liquid can circulate more fully in the container, and the uneven mixing area caused by poor flow is reduced. The feed rate of the cutter of the cutting machine is adjusted according to the average roughness of the incision of the burn patch. Since the cutting tool will appear after long-term use, Wear and tear make the cutting edge no longer sharp, resulting in problems such as uneven cutting and rough incisions. By reducing the cutter feed rate of the cutting machine, the cutter can have more sufficient contact time with the material during cutting. The depth and force of each cut are relatively small, and the cutting action can be completed more finely, thereby improving the cutting effect and making the incision smoother. The airflow circulation speed in the hot air circulation oven is adjusted according to the drying rate of the burn patch. Due to the aging of the heating elements in the drying equipment, the temperature in the drying equipment is uneven, which leads to uneven drying temperature. By increasing the airflow circulation speed in the hot air circulation oven, the low-temperature area can absorb heat faster and narrow the temperature gap with the high-temperature area, thereby improving the uniformity of temperature distribution and improving the preparation stability of the burn patch.

[0019] Furthermore, the method of the present invention adjusts the speed of the stirring motor of the agitator by setting a preset first variance and a preset second variance. Since during the dissolution process of the active ingredient, there is residual accumulation of active ingredients on the inner wall of the mixing container, which causes poor flow of the liquid during mixing, thereby causing uneven mixing. By increasing the speed of the stirring motor of the agitator, the agitator can provide a greater driving force to push the liquid to flow faster, which helps to overcome the flow resistance caused by the accumulation of residual substances, allowing the liquid to circulate more fully in the container, reducing the uneven mixing area caused by poor flow, and further improving the preparation stability of the burn patch.

[0020] Furthermore, the method of the present invention adjusts the tool feed rate of the cutting machine by setting a preset first roughness and a preset second roughness. Since the tool used for cutting will wear out after long-term use and the cutting edge will no longer be sharp, resulting in problems such as uneven cutting and rough incisions, by reducing the tool feed rate of the cutting machine, the tool can have a more sufficient contact time with the material during cutting, and the depth and force of each cutting are relatively small, so the cutting action can be completed more finely, thereby improving the cutting effect, making the incision smoother, and further improving the preparation stability of the burn patch.

[0021] Furthermore, the method of the present invention adjusts the airflow circulation speed in the hot air circulation oven by setting a preset drying rate. Due to the aging of the heating elements in the drying equipment, the temperature in the drying equipment is uneven, which leads to uneven drying temperature. By increasing the airflow circulation speed in the hot air circulation oven, the low-temperature area can absorb heat faster and narrow the temperature gap with the high-temperature area, thereby improving the uniformity of temperature distribution and further improving the preparation stability of the burn patch. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is an overall flow chart of a method for preparing a burn patch for treating skin wounds according to an embodiment of the present invention; Figure 2 This is a logic flow chart of a method for preparing a burn patch for treating skin wounds according to an embodiment of the present invention; Figure 3 This is a specific flow chart of a process for adjusting the speed of a stirring motor of a stirrer in a method for preparing a burn patch for treating skin wounds according to an embodiment of the present invention; Figure 4 This is a specific flow chart of the process of adjusting the feed rate of a cutter of a cutting machine in the method for preparing a burn patch for treating skin wounds according to an embodiment of the present invention. DETAILED DESCRIPTION

[0023] In order to make the objects and advantages of the present invention more clearly understood, the present invention is further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0024] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the protection scope of the present invention.

[0025] It should be noted that, in the description of the present invention, terms such as "up", "down", "left", "right", "inside" and "outside" indicating directions or positional relationships are based on the directions or positional relationships shown in the drawings. This is merely for the convenience of description and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present invention.

[0026] In addition, it should be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0027] See also Figure 1 , Figure 2 , Figure 3 as well as Figure 4 As shown, they are respectively an overall flow chart of a burn patch for treating skin wounds and a preparation method thereof according to an embodiment of the present invention, a logic flow chart, a specific flow chart of a process for adjusting the speed of a stirring motor of a stirrer, and a specific flow chart of a process for adjusting the feed rate of a cutter of a cutting machine. A preparation method of a burn patch for treating skin wounds according to the present invention comprises: Step S1, extracting collagen from fish by a bio-small molecule recovery method, using a stirrer to dissolve the active ingredient and the collagen into a solvent to output a mixed solution, bonding silica gel and nylon textile fabric to output an adhesive film patch, and coating the mixed solution on one side of the nylon textile fabric of the adhesive film patch; Step S2, using a hot air circulation oven to dry the adhesive film patch coated with the mixed solution, using a cutting machine to cut the dried adhesive film patch, and punching holes on the silicone side of the cut adhesive film patch to output the burn patch; Step S3, obtaining the concentration of the mixed solution at several sampling points; Step S4, determining the preparation stability of the burn patch based on the variance of the concentration of the mixed solution; Step S5, if the preparation stability does not meet the requirements, adjusting the speed of the stirring motor of the stirrer, or determining the molding effectiveness of the burn patch based on the average roughness of the incision of the burn patch; Step S6, if the molding effectiveness does not meet the requirements, the feed rate of the cutter of the cutting machine is adjusted, or the air circulation speed in the hot air circulation oven is adjusted based on the drying rate of the burn patch.

[0028] Specifically, the bio-small molecule recovery method is as follows: the fish maw, fish belly and fish skin are crushed to output the extraction raw material, the extraction raw material is extracted with ethanol solvent to output the extraction liquid, the extraction liquid is filtered, centrifuged and extracted in sequence to output the purified solution, and the purified solution is distilled and dried in sequence to output collagen powder.

[0029] Specifically, the parts where collagen is extracted include fish bladder, fish belly, and fish skin.

[0030] Specifically, the active ingredients include silver sulfadiazine, vitamin C, and hydrocortisone.

[0031] Specifically, the solvent includes water, ethanol, and propylene glycol.

[0032] Specifically, the mixed solution includes silver sulfadiazine, water, and sodium carboxymethylcellulose.

[0033] Specifically, the shapes of the holes include circle, diamond, square, +, and X.

[0034] Specifically, only the silicone layer is perforated.

[0035] Specifically, during the stretching process, the holes will become smaller due to lateral stretching.

[0036] Specifically, the method for detecting the concentration of a mixed solution is: divide the mixed solution into several solutions of equal mass, inject the several solutions into a high performance liquid chromatograph for analysis, and calculate the concentration of each component in the several solutions by comparing with a standard of known concentration.

[0037] Specifically, the tool feed rate of the cutting machine is the distance that the tool of the cutting machine advances in each cutting stroke.

[0038] In implementation, the method of the present invention adjusts the speed of the stirring motor of the stirrer according to the variance of the concentration of the mixed solution. Since there is residual accumulation of effective ingredients on the inner wall of the mixing container during the dissolution process of the effective ingredients, the liquid does not flow smoothly during mixing, resulting in uneven mixing. By increasing the speed of the stirring motor of the stirrer, the stirrer can provide a greater driving force to push the liquid to flow faster, which helps to overcome the flow resistance caused by the accumulation of residual substances, so that the liquid can circulate more fully in the container and reduce the uneven mixing area caused by poor flow. The cutter feed rate of the cutting machine is adjusted according to the average roughness of the incision of the burn patch. Since the cutting tool will wear out after long-term use, the cutting edge will no longer Sharpness leads to problems such as uneven cutting and rough incisions. By reducing the cutter feed rate of the cutting machine, the cutter can have more sufficient contact time with the material during cutting. The depth and force of each cut are relatively small, and the cutting action can be completed more finely, thereby improving the cutting effect and making the incision smoother. The airflow circulation speed in the hot air circulation oven is adjusted according to the drying rate of the burn patch. Due to the aging of the heating elements in the drying equipment, the temperature in the drying equipment is uneven, which leads to uneven drying temperature. By increasing the airflow circulation speed in the hot air circulation oven, the low-temperature area can absorb heat faster and narrow the temperature gap with the high-temperature area, thereby improving the uniformity of temperature distribution and improving the preparation stability of the burn patch.

[0039] Specifically, determining the preparation stability of the burn patch includes: Obtaining the concentration of the mixed solution at a number of sampling points, and calculating the variance of the concentration of the mixed solution; Comparing the variance of the concentration of the mixed solution with a preset first variance; If the variance of the concentration of the mixed solution is greater than the preset first variance, it is determined that the preparation stability of the burn patch does not meet the requirements.

[0040] Specifically, determining the molding effectiveness of the burn patch includes: Comparing the variance of the concentration of the mixed solution with the preset first variance and the preset second variance respectively; If the variance of the concentration of the mixed solution is greater than the preset first variance and less than or equal to the preset second variance, it is preliminarily determined that the molding effectiveness of the burn patch does not meet the requirements, and whether the molding effectiveness of the burn patch meets the requirements is determined based on the average roughness of the incision of the burn patch.

[0041] It can be understood that the three intervals divided by the preset first variance and the preset second variance correspond to three situations respectively: The first interval is that the variance of the concentration of the mixed solution is less than or equal to the preset first variance, and the corresponding situation is: determining that the preparation stability of the burn patch meets the requirements; The second interval is when the variance of the concentration of the mixed solution is greater than the preset first variance and less than or equal to the preset second variance. The corresponding situation is that the cutting tool will wear out after long-term use, and the edge is no longer sharp, resulting in problems such as unsmooth cutting and rough incision. The third interval is that the variance of the concentration of the mixed solution is greater than the preset second variance. The corresponding situation is: due to the accumulation of residual active ingredients on the inner wall of the mixing container during the dissolution of the active ingredients, the liquid does not flow smoothly during mixing, resulting in uneven mixing.

[0042] In practice, the default first variance is generally selected in the range of [0.5 (mol / L) 2 , 1.5 (mol / L) 2 ], the default second variance is generally selected in the range of [2 (mol / L) 2 , 3 (mol / L) 2 ].

[0043] Preferably, the preferred embodiment of the preset first variance is 1 (mol / L) 2 The default second variance is generally selected to be 2.5 (mol / L) 2 .

[0044] Specifically, the variance of the concentration of the mixed solution is the variance of the concentration of the mixed solution at several sampling points. The calculation method of the variance of the concentration of the mixed solution is a conventional technical means well known to those skilled in the art, so the calculation process of the variance of the concentration of the mixed solution will not be repeated here.

[0045] In implementation, the method of the present invention determines the preparation stability of the burn patch by setting a preset first variance and a preset second variance, thereby reducing the impact of the reduced preparation accuracy of the burn patch due to inaccurate determination of the preparation stability of the burn patch, and further improving the preparation stability of the burn patch.

[0046] Specifically, adjusting the speed of the stirring motor of the stirrer includes: Comparing the variance of the concentration of the mixed solution with the preset second variance; If the variance of the concentration of the mixed solution is greater than the preset second variance, the speed of the stirring motor of the stirrer is increased.

[0047] Specifically, the increase range of the rotation speed of the stirring motor of the stirrer is determined by the difference between the variance of the concentration of the mixed solution and a preset second variance.

[0048] Specifically, the difference between the variance of the concentration of the mixed solution and the preset second variance is 0.5 (mol / L) 2When the concentration variance of the mixed solution exceeds the preset second variance by more than 0.5 (mol / L), the stirring motor speed of the stirrer increases to 1.1 times of the original speed. 2 When the concentration increases to 1.1 times of the original value, the concentration increases by 0.2 (mol / L) 2 , the stirring motor speed of the stirrer increases by 20r / min. For example, the difference between the variance of the concentration of the mixed solution and the preset second variance is 0.9 (mol / L) 2 The current stirring motor speed of the stirrer is 300r / min, and the stirring motor speed of the enlarged stirrer is 300×1.1+20×2=370r / min.

[0049] In implementation, the method of the present invention adjusts the speed of the stirring motor of the agitator by setting a preset first variance and a preset second variance. Since there is residual accumulation of effective ingredients on the inner wall of the mixing container during the dissolution process of the effective ingredients, the liquid does not flow smoothly during mixing, resulting in uneven mixing. By increasing the speed of the stirring motor of the agitator, the agitator can provide a greater driving force to promote the liquid to flow faster, which helps to overcome the flow resistance caused by the accumulation of residual substances, so that the liquid can circulate more fully in the container, reduce the uneven mixing area caused by poor flow, and further improve the preparation stability of the burn patch.

[0050] Specifically, adjusting the feed rate of the cutter of the cutting machine includes: Obtaining the roughness of the cutouts on the same side of a plurality of burn patches, and calculating the average roughness of the cutouts of the burn patches; Comparing the average roughness of the burn patch incision with the preset first roughness and the preset second roughness respectively; If the average roughness of the burn patch cutout is greater than the preset first roughness, it is determined that the forming effectiveness of the burn patch does not meet the requirements; If the average roughness of the burn patch cutout is greater than the preset first roughness and less than or equal to the preset second roughness, reducing the tool feed rate of the cutting machine; If the average roughness of the burn patch incision is greater than the preset second roughness, it is preliminarily determined that the drying effectiveness of the burn patch does not meet the requirements, and whether the drying effectiveness of the burn patch meets the requirements is determined based on the drying rate of the burn patch.

[0051] It can be understood that the three intervals divided by the preset first roughness and the preset second roughness correspond to three situations respectively: The first interval is that the average roughness at the cut of the burn patch is less than or equal to the preset first roughness, and the corresponding situation is: it is determined that the molding effectiveness of the burn patch meets the requirements; The second interval is when the average roughness of the incision of the burn patch is greater than the preset first roughness and less than or equal to the preset second roughness. The corresponding situation is that the cutting tool will be worn after long-term use, and the edge is no longer sharp, resulting in problems such as unsmooth cutting and rough incision. The third interval is that the average roughness of the burn patch incision is greater than the preset second roughness, and the corresponding situation is: due to the aging of the heating element in the drying equipment, the temperature in the drying equipment is uneven, which leads to uneven drying temperature.

[0052] In practice, the preset first roughness is generally selected in the range of [3.5 μm, 4.5 μm], and the preset second roughness is generally selected in the range of [4.6 μm, 5.6 μm].

[0053] Preferably, the first preset roughness is 4 μm, and the second preset roughness is 5 μm.

[0054] Specifically, the average roughness at the incision of the burn patch is the ratio of the sum of the roughness at the incisions on the same side of a plurality of burn patches to the number of burn patches.

[0055] In implementation, the method of the present invention determines the molding effectiveness of the burn patch by setting a preset first roughness and a preset second roughness, thereby reducing the impact of the reduced preparation stability of the burn patch due to inaccurate determination of the molding effectiveness of the burn patch, and further improving the preparation stability of the burn patch.

[0056] Specifically, the reduction range of the feed rate of the cutter of the cutting machine is determined by the difference between the average roughness at the cut of the burn patch and the preset first roughness.

[0057] Specifically, when the difference between the average roughness at the incision of the burn patch and the preset first roughness is within 2μm, the tool feed rate of the cutting machine is reduced to 0.9 times the original value; when the difference between the average roughness at the incision of the burn patch and the preset first roughness exceeds 2μm, on the basis of being reduced to 0.9 times the original value, the tool feed rate of the cutting machine is reduced by 0.1mm / r for every 0.5μm exceeding it. For example, the difference between the average roughness at the incision of the burn patch and the preset first roughness is 3μm, the current tool feed rate of the cutting machine is 1mm / r, and the reduced tool feed rate of the cutting machine is 1×0.9-0.1×2=0.7mm / r.

[0058] Specifically, mm / r is the unit of the tool feed rate of the cutting machine, which means millimeter per revolution.

[0059] In implementation, the method of the present invention adjusts the tool feed rate of the cutting machine by setting a preset first roughness and a preset second roughness. Since the tool used for cutting will wear out after long-term use, the cutting edge will no longer be sharp, resulting in problems such as uneven cutting and rough incisions. By reducing the tool feed rate of the cutting machine, the tool can have a more sufficient contact time with the material during cutting, and the depth and force of each cutting are relatively small, so the cutting action can be completed more finely, thereby improving the cutting effect, making the incision smoother, and further improving the preparation stability of the burn patch.

[0060] Specifically, adjusting the airflow circulation speed in the hot air circulation oven includes: Obtain the mass of the burn patch per unit time and calculate the drying rate of the burn patch; comparing the drying rate of the burn patch with a preset drying rate; If the drying rate of the burn patch is less than the preset drying rate, it is determined that the drying effectiveness of the burn patch does not meet the requirements, and the airflow circulation speed in the hot air circulation oven is increased.

[0061] It can be understood that the two intervals of the preset drying rate correspond to two situations: The first interval is when the drying rate of the burn patch is less than the preset drying rate, and the corresponding situation is: due to the aging of the heating element in the drying device, the temperature in the drying device is uneven, which leads to uneven drying temperature; The second interval is that the drying rate of the burn patch is greater than or equal to the preset drying rate, and the corresponding situation is: determining that the drying effectiveness of the burn patch meets the requirements.

[0062] In practice, the preset drying rate is generally selected in the range of [0.1 g / h, 0.3 g / h].

[0063] Preferably, the preset drying rate is preferably 0.2 g / h.

[0064] Specifically, the drying rate of the burn patch is the ratio of the absolute value of the difference between the mass of the burn patch at the end time per unit time and the mass of the burn patch at the initial time per unit time to the duration per unit time.

[0065] In implementation, the method of the present invention determines the drying effectiveness of the burn patch by setting a preset drying rate, thereby reducing the impact of the reduced preparation stability of the burn patch due to inaccurate determination of the drying effectiveness of the burn patch, and further improving the preparation stability of the burn patch.

[0066] Specifically, the increase range of the airflow circulation speed in the hot air circulation oven is determined by the difference between the preset drying rate and the drying rate of the burn patch.

[0067] Specifically, when the difference between the preset drying rate and the drying rate of the burn patch is within 0.1g / h, the air flow circulation speed in the hot air circulation oven is increased to 1.2 times the original speed; when the difference between the preset drying rate and the drying rate of the burn patch exceeds 0.1g / h, on the basis of being increased to 1.2 times the original speed, the air flow circulation speed in the hot air circulation oven is increased by 0.5m / s for every 0.1g / h exceeding the original speed. For example, the difference between the preset drying rate and the drying rate of the burn patch is 0.3g / h, the current air flow circulation speed in the hot air circulation oven is 2m / s, and the increased air flow circulation speed in the hot air circulation oven is 2×1.2+0.5×2=3.4m / s.

[0068] In implementation, the method of the present invention adjusts the airflow circulation speed in the hot air circulation oven by setting a preset drying rate. Due to the aging of the heating elements in the drying equipment, the temperature in the drying equipment is uneven, which leads to uneven drying temperature. By increasing the airflow circulation speed in the hot air circulation oven, the low-temperature area can absorb heat faster and narrow the temperature gap with the high-temperature area, thereby improving the uniformity of temperature distribution and further improving the preparation stability of the burn patch.

[0069] A burn patch for treating skin wounds, comprising: silica gel, nylon textile cloth, type I collagen, vitamin C and glycerin.

[0070] So far, the technical solutions of the present invention have been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

Claims

1. A method for preparing a burn patch for treating skin wounds, characterized in that: include: Extracting collagen from fish by a bio-small molecule recovery method, dissolving effective ingredients and the collagen into a solvent using a stirrer to output a mixed solution, bonding silica gel and nylon textile fabric to output an adhesive film patch, and coating the mixed solution on one side of the nylon textile fabric of the adhesive film patch; The adhesive film patch coated with the mixed solution is dried using a hot air circulation oven, the dried adhesive film patch is cut using a cutting machine, and holes are punched on the silicone side of the cut adhesive film patch to output the burn patch; Obtaining the concentration of the mixed solution at several sampling points; The stability of the preparation of the burn patch was determined based on the variance of the concentration of the mixed solution; If the preparation stability does not meet the requirements, the speed of the stirring motor of the stirrer is adjusted, or the molding effectiveness of the burn patch is determined based on the average roughness of the incision of the burn patch; If the molding effectiveness does not meet the requirements, the feed rate of the cutter of the cutting machine is adjusted, or the air circulation speed in the hot air circulation oven is adjusted based on the drying rate of the burn patch; The increase range of the stirring motor speed of the stirrer is determined by the difference between the variance of the concentration of the mixed solution and a preset second variance; The difference between the variance of the concentration of the mixed solution and the preset second variance is 0.5 (mol / L) 2 When the concentration variance of the mixed solution exceeds the preset second variance by more than 0.5 (mol / L), the stirring motor speed of the stirrer increases to 1.1 times of the original speed. 2 When the concentration increases to 1.1 times of the original value, the concentration increases by 0.2 (mol / L) 2 , the stirring motor speed of the stirrer increases by 20r / min; The reduction range of the feed rate of the cutter of the cutting machine is determined by the difference between the average roughness of the cutout of the burn patch and the preset first roughness; When the difference between the average roughness of the burn patch incision and the preset first roughness is within 2μm, the tool feed rate of the cutting machine is reduced to 0.9 times of the original value; when the difference between the average roughness of the burn patch incision and the preset first roughness exceeds 2μm, on the basis of being reduced to 0.9 times of the original value, the tool feed rate of the cutting machine is reduced by 0.1mm / r for every 0.5μm exceeding the original value; The increase range of the air circulation speed in the hot air circulation oven is determined by the difference between the preset drying rate and the drying rate of the burn patch; When the difference between the preset drying rate and the drying rate of the burn patch is within 0.1g / h, the air flow circulation speed in the hot air circulation oven is increased to 1.2 times the original speed; when the difference between the preset drying rate and the drying rate of the burn patch exceeds 0.1g / h, on the basis of being increased to 1.2 times the original speed, the air flow circulation speed in the hot air circulation oven is increased by 0.5m / s for every 0.1g / h exceeding the original speed.

2. The method for preparing a burn patch for treating skin wounds according to claim 1, characterized in that: Determining the preparation stability of the burn patch includes: Comparing the variance of the concentration of the mixed solution with a preset first variance; If the variance of the concentration of the mixed solution is greater than the preset first variance, it is determined that the preparation stability of the burn patch does not meet the requirements.

3. The method for preparing a burn patch for treating skin wounds according to claim 2, characterized in that: Determining the molding effectiveness of the burn patch includes: Comparing the variance of the concentration of the mixed solution with the preset first variance and the preset second variance respectively; If the variance of the concentration of the mixed solution is greater than the preset first variance and less than or equal to the preset second variance, it is preliminarily determined that the molding effectiveness of the burn patch does not meet the requirements, and whether the molding effectiveness of the burn patch meets the requirements is determined based on the average roughness of the incision of the burn patch.

4. The method for preparing a burn patch for treating skin wounds according to claim 3, characterized in that: The stirring motor speed of the stirrer is adjusted, comprising: Comparing the variance of the concentration of the mixed solution with the preset second variance; If the variance of the concentration of the mixed solution is greater than the preset second variance, the speed of the stirring motor of the stirrer is increased.

5. The method for preparing a burn patch for treating skin wounds according to claim 4, characterized in that: The feed rate of the cutter of the cutting machine is adjusted, including: The average roughness of the burn patch incision is compared with the preset first roughness and the preset second roughness respectively; If the average roughness of the burn patch cutout is greater than the preset first roughness, it is determined that the forming effectiveness of the burn patch does not meet the requirements; If the average roughness of the burn patch cutout is greater than the preset first roughness and less than or equal to the preset second roughness, reducing the tool feed rate of the cutting machine; If the average roughness of the burn patch incision is greater than the preset second roughness, it is preliminarily determined that the drying effectiveness of the burn patch does not meet the requirements, and whether the drying effectiveness of the burn patch meets the requirements is determined based on the drying rate of the burn patch.

6. The method for preparing the burn patch for treating skin wounds according to claim 5, characterized in that: The airflow circulation speed in the hot air circulation oven is adjusted, including: Compare the drying rate of the burn patch with the preset drying rate; If the drying rate of the burn patch is less than the preset drying rate, it is determined that the drying effectiveness of the burn patch does not meet the requirements, and the airflow circulation speed in the hot air circulation oven is increased.

7. A burn patch made by the method for preparing a burn patch for treating skin wounds according to any one of claims 1 to 6, characterized in that: include: Silicone, nylon textile fabric, type I collagen, vitamin C, glycerin.

Images