Agilawood essence capable of preventing hair loss and growing hair and preparation method of agilawood essence

Abstract

The invention discloses agilawood essence for preventing hair loss and nourishing hair. The agilawood essence is prepared from an anti-hair loss and hair nourishing composition, a thickening agent, a humectant, a preservative, an organic solvent and water, the hair loss preventing and hair growing composition accounts for 12-25% of the total mass of the agilawood essence for preventing hair loss and hair growing; the hair loss preventing and hair growing composition comprises the following components in parts by weight: 15-22 parts of agilawood essential oil, 4-7 parts of carnosic acid, 2-5 parts of pomegranate flower polysaccharide and 1-3 parts of panax japonicus polysaccharide. The agilawood essential oil, the carnosic acid, the pomegranate flower polysaccharide and the panax japonicus polysaccharide have a synergistic effect, so that not only is an obvious 5a-reductase inhibition effect achieved, but also the number of skin hair follicles is obviously increased, hair growth is promoted, the hair quality is improved, and the effects of preventing hair loss and growing hair are comprehensively achieved. In addition, according to the preparation method of the agilawood essence for preventing hair loss and growing hair, the prepared agilawood essence is fine in liquid drop granularity, good in dispersity and high in stability, and the absorption efficiency and the utilization degree of the essence can be further improved.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemical products, and in particular to an agarwood essence liquid for preventing hair loss and promoting hair growth and a preparation method thereof. Background Art

[0002] With the accelerated pace of modern life, hair loss has become a challenge faced by many people. The main causes of hair loss are as follows: (1) Genetics is one of the main causes of hair loss, especially androgenic alopecia, also known as male pattern baldness; (2) Changes in hormone levels, such as increased androgen levels, may shorten the hair growth cycle and accelerate hair loss; (3) Malnutrition, lack of adequate protein, iron, zinc, vitamin D and other essential nutrients may cause hair brittleness and loss; (4) Long-term mental stress and emotional tension may cause arrector pili muscles to contract, affecting hair growth; (5) Side effects of drugs, certain drugs, such as anticancer drugs, antidepressants and anticoagulants, may cause hair loss as a side effect; (6) Bad living habits, such as smoking, excessive drinking and irregular work and rest, may also have a negative impact on hair health. Hair loss not only affects personal image, but may also be associated with health problems. Therefore, the importance of preventing hair loss and promoting hair growth is becoming increasingly prominent.

[0003] As early as in ancient times, people realized the importance of hair and tried to use natural herbs and plant extracts to promote hair growth. For example, ancient China used Chinese medicinal materials such as Polygonum multiflorum and Lycium barbarum to nourish hair. Although the products at that time may not be scientific and effective, they laid the foundation for later development. In the 1980s, the FDA approved minoxidil as a topical treatment for androgenic alopecia. This breakthrough led to the emergence of a variety of anti-hair loss shampoos, conditioners and other products on the market, combining the efficacy of drugs with the functions of daily care. Some chemical ingredients may have potential side effects, such as skin allergies and hormonal imbalances. Many anti-hair loss products are effective in the short term, but the long-term effects and sustainability have not been fully verified. Therefore, it is of great significance to develop a safer, more effective and economical anti-hair loss and hair growth product. Summary of the invention

[0004] In view of this, the present invention proposes an agarwood essence for preventing hair loss and promoting hair growth and a preparation method thereof to solve the above problems.

[0005] The technical solution of the present invention is achieved in this way:

[0006] A kind of agarwood essence for preventing hair loss and promoting hair growth, comprising an anti-hair loss and promoting hair growth composition, a thickener, a moisturizer, a preservative, an organic solvent and water; the anti-hair loss and promoting hair growth composition accounts for 12% to 25% of the total mass of the agarwood essence for preventing hair loss and promoting hair growth; the anti-hair loss and promoting hair growth composition comprises, by weight: 15 to 22 parts of agarwood essential oil, 4 to 7 parts of carnosic acid, 2 to 5 parts of pomegranate flower polysaccharide and 1 to 3 parts of Panax japonicus polysaccharide.

[0007] Preferably, the thickener, moisturizer and preservative account for 0.4% to 0.8%, 3% to 8% and 0.08% to 0.2% of the total mass ratio of the agarwood essence for preventing hair loss and promoting hair growth, respectively.

[0008] Preferably, the organic solvent is ethanol, and the organic solvent accounts for 5% to 15% of the total mass of the agarwood essence for preventing hair loss and promoting hair growth.

[0009] Preferably, the thickener is at least one of castor oil polyoxyethylene ether, stearamidopropyl dimethylamine, and polydimethylsiloxane alcohol.

[0010] Preferably, the moisturizer is at least one of propylene glycol, 1,2-hexanediol, glycerol, and sodium hyaluronate.

[0011] Preferably, the preservative is at least one of chlorphenesin, phenoxyethanol and sodium benzoate.

[0012] Preferably, the preparation method of the agarwood essential oil is: take fresh agarwood branches and leaves, wash, dry, and grind into powder, place the powder in a CO2 supercritical extraction kettle, add anhydrous ethanol at a solid-liquid ratio of 1:6-8g / mL, mix and perform supercritical CO2 extraction, the extraction temperature is 35-45°C, the pressure is 1.2-1.8MPa, and the extraction time is 45-60min to obtain agarwood essential oil.

[0013] Preferably, the preparation method of the pomegranate flower polysaccharide is: take fresh pomegranate flowers, extract them with hot water, filter, precipitate with alcohol, centrifuge, separate the precipitate, deproteinize the precipitate, dialyze and freeze-dry to obtain the pomegranate flower polysaccharide; the hot water extraction conditions include: temperature control at 80-95°C, water-to-material ratio of 15-20:1 (mL / g), and extraction time of 1.5 to 2 hours.

[0014] Preferably, the preparation method of the Panax notoginseng polysaccharide is: take the dried rhizome of Panax notoginseng, crush it, extract it with hot water, filter it, precipitate it with alcohol, centrifuge it, separate the precipitate, deproteinize the precipitate, dialyze and freeze-dry it to obtain Panax notoginseng polysaccharide; the hot water extraction conditions include: temperature control at 75-90°C, water-to-material ratio of 20-25:1 (mL / g), and extraction time of 2 to 3 hours.

[0015] The present invention also provides a method for preparing agarwood essence for preventing hair loss and promoting hair growth, comprising the following steps:

[0016] S1. Weigh the required raw materials in proportion, completely dissolve the weighed agarwood essential oil, carnosic acid, pomegranate flower polysaccharide, and panax japonicus polysaccharide in an organic solvent, add a thickener and stir well to obtain an oil phase;

[0017] S2. Add water droplets into the oil phase under stirring conditions, and control the stirring speed at 600-1200r / min;

[0018] S3. After all the water is added, continue to add moisturizer and preservative under stirring, and homogenize for 30 to 40 minutes to obtain the essence.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] The present invention provides an anti-hair loss and hair growth agarwood essence, comprising an anti-hair loss and hair growth composition, a thickener, a moisturizer, a preservative, an organic solvent and water, wherein the anti-hair loss and hair growth composition is composed of agarwood essential oil, carnosic acid, pomegranate flower polysaccharide and bamboo joint ginseng polysaccharide in a reasonable ratio, and the four components synergize and enhance the effect, not only having a significant 5a-reductase inhibition effect, and can be used to inhibit hair loss, but also significantly increasing the number of skin hair follicles, promoting hair growth and improving hair quality, and comprehensively achieving the effect of anti-hair loss and hair growth. In addition, the present invention provides a method for preparing an anti-hair loss and hair growth agarwood essence, wherein the obtained agarwood essence has fine droplet size, good dispersibility and high stability, which helps to further improve the absorption efficiency and utilization of the essence. DETAILED DESCRIPTION

[0021] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0022] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0023] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0024] The preparation methods of agarwood essential oil, pomegranate flower polysaccharide, and Panax japonicus polysaccharide in Examples 1-3 of the present invention are as follows:

[0025] The preparation method of agarwood essential oil is as follows: take fresh agarwood branches and leaves, wash, dry, and grind into powder, place the powder in a CO2 supercritical extraction kettle, add anhydrous ethanol at a solid-liquid ratio of 1:8g / mL, mix and perform supercritical CO2 extraction, the extraction temperature is 40°C, the pressure is 1.5MPa, and the extraction time is 60min to obtain agarwood essential oil.

[0026] The preparation method of pomegranate flower polysaccharide is as follows: fresh pomegranate flowers are extracted with hot water, the extraction temperature is controlled at 90°C, the water-to-solid ratio is 15:1 (mL / g), the extraction time is 2 hours, and then filtered, 5 times the volume of 75% ethanol is added to the filtrate, and the filtrate is allowed to stand for 24 hours at 5°C, centrifuged, and the precipitate is separated, the precipitate is redissolved, 1 / 5 volume of Sevage solution (the mass ratio of chloroform to n-butanol is 5:1) is added to remove protein, and the upper polysaccharide solution is allowed to stand and centrifuged after shaking on a shaker for 30 minutes, and the process is repeated many times until no protein is detected, and the pomegranate flower polysaccharide is obtained by rotation concentration, dialyzed (with a molecular weight cutoff of 3000Da), and then freeze-dried for storage.

[0027] The preparation method of Panax notoginseng polysaccharide is as follows: take the dried rhizome of Panax notoginseng, crush it and then extract it with hot water, the extraction temperature is controlled at 85°C, the water-to-solid ratio is 25:1 (mL / g), the extraction time is 3 hours, and then filter, add 3 times the volume of 95% ethanol to the filtrate, let it stand at 5°C for 24 hours, centrifuge, separate the precipitate, redissolve the precipitate, add 1 / 5 volume of Sevage solution (the mass ratio of chloroform to n-butanol is 5:1) to remove protein, shake on a shaker for 30 minutes, let it stand and centrifuge the upper polysaccharide solution, repeat several times until no protein is detected, rotate and concentrate, dialyze (with a molecular weight cutoff of 2000Da) and then freeze-dry for storage to obtain Panax notoginseng polysaccharide.

[0028] Example 1

[0029] A kind of agarwood essence for preventing hair loss and promoting hair growth, comprising by weight percentage: 12% of an anti-hair loss and promoting hair growth composition, 0.4% of a thickener, 8% of a moisturizer, 0.08% of a preservative, 5% of ethanol and the balance of water; the anti-hair loss and promoting hair growth composition comprises by weight: 15 parts of agarwood essential oil, 7 parts of carnosic acid, 2 parts of pomegranate flower polysaccharide and 3 parts of panax japonicus polysaccharide; the thickener is polydimethylsiloxane; the moisturizer is a mixture of propylene glycol and sodium hyaluronate, and the mass ratio of the two is 1:1; the preservative is chlorphenesin.

[0030] The method for preparing the agarwood essence for preventing hair loss and promoting hair growth comprises the following steps:

[0031] S1. Weigh the required raw materials in proportion, completely dissolve the weighed agarwood essential oil, carnosic acid, pomegranate flower polysaccharide, and panax japonicus polysaccharide in ethanol, add a thickener and stir well to obtain an oil phase;

[0032] S2. Slowly add water to the oil phase under stirring conditions, and control the stirring speed at 600r / min;

[0033] S3. After all the water is added, continue to add moisturizer and preservative under stirring, and then homogenize for 30 minutes at a homogenization speed of 1000r / min to obtain the essence.

[0034] Example 2

[0035] A kind of agarwood essence for preventing hair loss and promoting hair growth, comprising by weight percentage: 20% of an anti-hair loss and promoting hair growth composition, 0.6% of a thickener, 5% of a moisturizer, 0.1% of a preservative, 10% of ethanol and the balance of water; the anti-hair loss and promoting hair growth composition comprises by weight: 20 parts of agarwood essential oil, 5 parts of carnosic acid, 3 parts of pomegranate flower polysaccharide and 2 parts of panax japonicus polysaccharide; the thickener is castor oil polyoxyethylene ether; the moisturizer is a mixture of 1,2-hexanediol and glycerol, and the mass ratio of the two is 1:1; the preservative is sodium benzoate.

[0036] The method for preparing the agarwood essence for preventing hair loss and promoting hair growth comprises the following steps:

[0037] S1. Weigh the required raw materials in proportion, completely dissolve the weighed agarwood essential oil, carnosic acid, pomegranate flower polysaccharide, and panax japonicus polysaccharide in ethanol, add a thickener and stir well to obtain an oil phase;

[0038] S2. Slowly add water to the oil phase under stirring conditions, and control the stirring speed at 1000r / min;

[0039] S3. After all the water is added, continue to add moisturizer and preservative under stirring, and then homogenize for 40 minutes at a homogenization speed of 1000r / min to obtain the essence.

[0040] Example 3

[0041] A kind of agarwood essence for preventing hair loss and promoting hair growth, comprising by weight percentage: 25% of an anti-hair loss and promoting hair growth composition, 0.8% of a thickener, 3% of a moisturizer, 0.2% of a preservative, 15% of ethanol and the balance of water; the anti-hair loss and promoting hair growth composition comprises by weight: 22 parts of agarwood essential oil, 4 parts of carnosic acid, 5 parts of pomegranate flower polysaccharide and 1 part of panax japonicus polysaccharide; the thickener is a mixture of castor oil polyoxyethylene ether and stearamidopropyl dimethylamine, and the mass ratio of the two is 1:1; the moisturizer is propylene glycol; the preservative is a mixture of phenoxyethanol and sodium benzoate, and the mass ratio of the two is 1:1.

[0042] The method for preparing the agarwood essence for preventing hair loss and promoting hair growth comprises the following steps:

[0043] S1. Weigh the required raw materials in proportion, completely dissolve the weighed agarwood essential oil, carnosic acid, pomegranate flower polysaccharide, and panax japonicus polysaccharide in ethanol, add a thickener and stir well to obtain an oil phase;

[0044] S2. Slowly add water to the oil phase under stirring conditions, and control the stirring speed at 1200r / min;

[0045] S3. After all the water is added, continue to add moisturizer and preservative under stirring, and then homogenize for 30 minutes at a homogenization speed of 1000r / min to obtain the essence.

[0046] Comparative Example 1

[0047] The difference between this comparative example and Example 2 is that the anti-hair loss and hair growth composition in the agarwood essence for preventing hair loss and hair growth in this example is a single agarwood essential oil; the preparation method of the agarwood essence for preventing hair loss and hair growth in this example is basically the same as that in Example 2.

[0048] Comparative Example 2

[0049] The difference between this comparative example and Example 2 is that the anti-hair loss and hair growth composition in the agarwood essence for preventing hair loss and hair growth in this example does not contain carnosic acid, and the missing amount of carnosic acid is proportionally distributed to the other components in the anti-hair loss and hair growth composition; the preparation method of the agarwood essence for preventing hair loss and hair growth in this example is basically the same as that in Example 2.

[0050] Comparative Example 3

[0051] The difference between this comparative example and Example 2 is that the anti-hair loss and hair growth composition in the agarwood essence for preventing hair loss and hair growth in this example does not contain pomegranate flower polysaccharide, and the missing amount of pomegranate flower polysaccharide is proportionally distributed to the other components in the anti-hair loss and hair growth composition; the preparation method of the agarwood essence for preventing hair loss and hair growth in this example is basically the same as that in Example 2.

[0052] Comparative Example 4

[0053] The difference between this comparative example and Example 2 is that the anti-hair loss and hair growth composition in the agarwood essence for preventing hair loss and hair growth in this example does not contain Panax notoginseng polysaccharide, and the missing amount of Panax notoginseng polysaccharide is proportionally distributed to the other components in the anti-hair loss and hair growth composition; the preparation method of the agarwood essence for preventing hair loss and hair growth in this example is basically the same as that in Example 2.

[0054] Comparative Example 5

[0055] The difference between this comparative example and Example 2 is that the preparation method of the agarwood essence for preventing hair loss and promoting hair growth in this example is:

[0056] Weigh the required raw materials in proportion, completely dissolve the weighed agarwood essential oil, carnosic acid, pomegranate flower polysaccharide, and panax japonicus polysaccharide in ethanol, then add a thickener, a moisturizer, a preservative and the remainder of water, and then homogenize for 40 minutes at a homogenization speed of 1000r / min to obtain the essence.

[0057] Test Example 1 5a-Reductase Inhibition Effect Test

[0058] Preparation of 5α-reductase: Take 10 SD male rats, fast for 12 hours and then kill them. Dissect and remove the prostate of the rats, cut them into pieces and weigh them. Add pre-cooled buffer (containing 0.32 mol / L sucrose, 0.1 mmol / L dithiothreitol, 1 mmol / L ethylenediaminetetraacetic acid and 0.2 mol / L phosphate buffer) at a mass ratio of 1:5, quickly make a homogenate in a homogenizer, centrifuge for 10 minutes in a refrigerated centrifuge, take the supernatant and add buffer to 20 mL, divide into EP tubes, and store in a -80℃ refrigerator for later use.

[0059] 5α-reductase activity determination: 0.5mL phosphate buffer, 0.2mL test sample, 0.2mL testosterone solution (300mg / L) and 0.2mL NADPH solution (0.8g / L) were added to the test tube in sequence, and finally 0.5mL 5α-reductase extract was added, and the reaction was carried out at 37°C for 30min. After the reaction, 3mL dichloromethane was added to stop the reaction and extract testosterone, and then 0.25mL propyl hydroxybenzoate (100mg / L) was added as an internal standard, centrifuged (5000r / min, 10min), the upper aqueous phase was removed, about 1mL of the organic phase was transferred and evaporated, and the residue was dissolved in 1.5mL methanol, and the residual testosterone content was determined by high performance liquid chromatography. The positive control was the 0.05mg / L finasteride group, and a 5α-reductase reaction tube and a 5α-reductase blank tube were set at the same time.

[0060] 5α-reductase inhibition rate = (R 样品 -R 反应 ) / (R 空白 -R 反应 )×100%; where R is the ratio of the target peak area to the internal standard peak area.

[0061] The test samples were the agarwood essences for preventing hair loss and promoting hair growth obtained in Examples 1-3 and Comparative Examples 1-5. The test results are shown in Table 1.

[0062] Table 1

[0063] Group Inhibition rate (%) Example 1 84.1 Example 2 88.2 Example 3 87.3 Comparative Example 1 71.8 Comparative Example 2 79.7 Comparative Example 3 82.2 Comparative Example 4 78.6 Comparative Example 5 64.2 Finasteride 92.5

[0064] As can be seen from the results in Table 1, the agarwood essence for preventing hair loss and promoting hair growth prepared by the present invention has a high inhibition rate on 5α-reductase, while the inhibition rate of 5α-reductase in Comparative Examples 1-4 is significantly lower than that in Example 2, indicating that the anti-hair loss and hair growth composition in the agarwood essence for preventing hair loss and promoting hair growth of the present invention can synergistically enhance the effect of inhibiting the activity of 5α-reductase, thereby having a better preventive and therapeutic effect on hair loss. The inhibition rate of 5α-reductase in Comparative Example 5 is significantly lower than that in Example 2, indicating that the process for preparing the agarwood essence for preventing hair loss and promoting hair growth of the present invention can enhance its effect of inhibiting the activity of 5α-reductase.

[0065] Experimental Example 2 Effect of the Agarwood Essence for Anti-hair Loss and Hair Growth of the Present Invention on Hair Growth in Mice with Seborrheic Alopecia

[0066] SPF grade 5-7 week old male mice were randomly divided into blank group, model group, positive control group, Example 1-3 group, Comparative Example 1-5 group, 8 mice in each group. After the mice were anesthetized, the mice were shaved, and the depilatory area was 2cm×3cm. 0.05% testosterone propionate injection 0.1ml was applied to the depilatory area, and 5mg / (kg.d) of testosterone propionate injection was subcutaneously injected into the back of the neck, once a day, and the injection was continuously applied for 30 days. The morphology of hair follicles was observed by HE staining of the back skin of the mice on the 30th day. The number of hair follicles in the back skin of the mice was significantly reduced, and the seborrheic alopecia model was successfully established. The positive control group applied 5% minoxidil 0.5mg to the depilatory area twice a day; Example 1-3 group and Comparative Example 1-5 group applied 0.5mg of agarwood essence for anti-hair loss and hair growth to the depilatory area each time, twice a day; the blank group and the model group were coated with an equal amount of normal saline. After 28 days, the hair growth of mice in each group was observed, and then the mice were killed and the skin tissue was taken for HE staining to count the number of hair follicles. The results are shown in Table 2.

[0067] Table 2

[0068]

[0069] It can be seen from the results in Table 2 that applying the agarwood essence for preventing hair loss and promoting hair growth prepared in Examples 1-3 of the present invention can significantly increase the number of skin hair follicles, promote hair growth, and improve hair quality.

[0070] Test Example 3

[0071] The particle size and dispersion coefficient of the agarwood essence for preventing hair loss and promoting hair growth were measured by dynamic light scattering method. The test results are shown in Table 3.

[0072] Table 3

[0073] Group Average particle size (nm) Dispersion coefficient Example 1 173.7 0.412 Example 2 150.1 0.322 Example 3 162.3 0.359 Comparative Example 5 286.8 0.758

[0074] The results in Table 3 show that the droplet size of the agarwood essence liquid for preventing hair loss and promoting hair growth prepared by the present invention is finer and its specific surface area is relatively larger, which helps to improve the absorption efficiency and utilization of the essence liquid, and it is evenly dispersed, highly stable, and not prone to sedimentation; the droplet size of the agarwood essence liquid obtained in Comparative Example 5 is large and its dispersibility is poor.

[0075] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. An agarwood essence for preventing hair loss and promoting hair growth, characterized in that: The invention comprises an anti-hair loss and hair growth composition, a thickener, a moisturizer, a preservative, an organic solvent and water; the anti-hair loss and hair growth composition accounts for 12% to 25% of the total mass of the agarwood essence for anti-hair loss and hair growth; the anti-hair loss and hair growth composition comprises, by weight: 15 to 22 parts of agarwood essential oil, 4 to 7 parts of carnosic acid, 2 to 5 parts of pomegranate flower polysaccharide and 1 to 3 parts of panax japonicus polysaccharide.

2. The agarwood essence for preventing hair loss and promoting hair growth according to claim 1, characterized in that: The thickener, moisturizer and preservative account for 0.4% to 0.8%, 3% to 8% and 0.08% to 0.2% of the total mass of the agarwood essence for preventing hair loss and promoting hair growth, respectively.

3. The agarwood essence for preventing hair loss and promoting hair growth according to claim 1, characterized in that: The organic solvent is ethanol, and the organic solvent accounts for 5% to 15% of the total mass of the agarwood essence liquid for preventing hair loss and promoting hair growth.

4. The agarwood essence for preventing hair loss and promoting hair growth according to claim 1, characterized in that: The thickener is at least one of castor oil polyoxyethylene ether, stearamidopropyl dimethylamine and polydimethylsiloxane alcohol.

5. The agarwood essence for preventing hair loss and promoting hair growth according to claim 1, characterized in that: The moisturizing agent is at least one of propylene glycol, 1,2-hexanediol, glycerol and sodium hyaluronate.

6. The agarwood essence for preventing hair loss and promoting hair growth according to claim 1, characterized in that: The preservative is at least one of chlorphenesin, phenoxyethanol and sodium benzoate.

7. The agarwood essence for preventing hair loss and promoting hair growth according to claim 1, characterized in that: The preparation method of the agarwood essential oil is as follows: fresh agarwood branches and leaves are washed, dried, and ground into powder, the powder is placed in a CO2 supercritical extraction kettle, anhydrous ethanol is added according to a solid-liquid ratio of 1:6-8 g / mL, and then supercritical CO2 extraction is performed, the extraction temperature is 35-45°C, the pressure is 1.2-1.8 MPa, and the extraction time is 45-60 min to obtain the agarwood essential oil.

8. The agarwood essence for preventing hair loss and promoting hair growth according to claim 1, characterized in that: The preparation method of the pomegranate flower polysaccharide comprises the following steps: extracting fresh pomegranate flowers with hot water, filtering, precipitating with alcohol, centrifuging, separating precipitates, deproteinizing the precipitates, dialyzing and freeze-drying to obtain the pomegranate flower polysaccharide; The hot water extraction conditions include: temperature control at 80-95° C., water-to-solid ratio at 15-20:1 (mL / g), and extraction time at 1.5-2 hours.

9. The agarwood essence for preventing hair loss and promoting hair growth according to claim 1, characterized in that: The preparation method of the polysaccharide of Panax japonicus is as follows: taking the dried rhizome of Panax japonicus, crushing it, extracting it with hot water, filtering it, precipitating it with alcohol, centrifuging it, separating out the precipitate, deproteinizing the precipitate, dialyzing and freeze-drying it to obtain the polysaccharide of Panax japonicus; The hot water extraction conditions include: temperature controlled at 75-90° C., water-to-solid ratio of 20-25:1 (mL / g), and extraction time of 2-3 hours.

10. The method for preparing the agarwood essence for preventing hair loss and promoting hair growth according to any one of claims 1 to 9, characterized in that: The following steps are involved: S1. Weigh the required raw materials in proportion, completely dissolve the weighed agarwood essential oil, carnosic acid, pomegranate flower polysaccharide, and panax japonicus polysaccharide in an organic solvent, add a thickener and stir well to obtain an oil phase; S2. Add water droplets into the oil phase under stirring conditions, and control the stirring speed at 600-1200r / min; S3. After all the water is added, continue to add moisturizer and preservative under stirring, and homogenize for 30 to 40 minutes to obtain the essence.

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