Novel titanium-free shading soft capsule and preparation method thereof

Abstract

The invention discloses a novel titanium-free shading soft capsule and a preparation method thereof, and belongs to the technical field of medicines and health foods. The capsule wall material of the soft capsule comprises 35-45% of gelatin, 15-23% of glycerin, 30-40% of purified water, 3-5% of composite calcium carbonate, 0.5-0.7% of an emulsifier and 0-2% of a pigment. Wherein the composite calcium carbonate is composed of light calcium carbonate and heavy calcium carbonate. According to the soft capsule disclosed by the invention, the light calcium carbonate and the heavy calcium carbonate are compounded, and the emulsifier polyglycerol fatty acid ester in a specific proportion is matched, so that the shading effect and the stability which are equivalent to those of titanium dioxide are realized, and the potential risk of titanium dioxide on the environment and human health is reduced. Meanwhile, the production process is simplified, large-scale production is facilitated, and a safe, healthy and environment-friendly shading solution is provided.

Description

Technical Field

[0001] The invention relates to the technical field of soft capsules, and in particular to a novel titanium-free light-shielding soft capsule and a preparation method thereof. Background Art

[0002] As a traditional food and drug dosage form, soft capsules are favored by consumers due to their portability, aesthetics, and ease of swallowing. Among them, some soft capsule contents are sensitive to light and easily decomposed by light, thus affecting the stability and efficacy of the drug. It is necessary to add a sunscreen to effectively prevent light from passing through the capsule shell and protect the contents from the influence of light, thereby ensuring the stability and effectiveness of the contents.

[0003] In the prior art, titanium dioxide (TiO2) has been widely used as a common sunscreen in food packaging materials such as soft capsules. However, in recent years, there have been constant controversies about the safety of titanium dioxide in food, and the International Agency for Research on Cancer (IARC) has classified it as a Class 2B carcinogen. The European Chemicals Agency also recommends that it be included in the category of substances that may cause cancer. After titanium dioxide is released in the environment, it can migrate between different environmental media through atmospheric deposition, water flow, and soil infiltration, affecting the cell membrane permeability, enzyme activity or gene expression of aquatic organisms, and affecting soil microorganisms, plant roots or soil physical and chemical properties. France announced a ban on the sale of foods containing titanium dioxide (TiO2) from January 1, 2020, based on an opinion issued by the French Food Safety Agency (ANSES). The opinion recommends reducing the impact of titanium dioxide on workers, consumers and the environment. Therefore, finding a safe and effective sunscreen that can replace titanium dioxide has become a hot topic in current research.

[0004] At present, there are patents that disclose solutions to replace titanium dioxide in soft capsules. The sunscreens selected are mainly calcium carbonate, calcium phosphate, talcum powder, nano zinc oxide, etc. However, when calcium carbonate or other calcium sources are used alone as sunscreens, there are problems such as poor dispersibility and insufficient covering power, which cannot meet the requirements for soft capsule preparation. Talc may bring in impurities during mining and processing, which may pose a threat to the quality and safety of soft capsules. The preparation process of nano zinc oxide is relatively complicated and the cost is relatively high. In addition, its performance in practical applications requires more experimental data support. Therefore, it is of great practical significance and application value to develop a new type of titanium-free sunscreen soft capsule, which can replace titanium dioxide and maintain the sunscreen, stability and production efficiency of soft capsules through specific capsule material composition and ratio. Summary of the invention

[0005] The purpose of the present invention is to provide a novel titanium-free sunshade soft capsule and a preparation method thereof. The composition uses compound calcium carbonate and adds the emulsifier polyglycerol fatty acid ester in a specific proportion to the soft capsule material to replace titanium dioxide as a sunshade, and achieves the same or even better sunshade, stability and production efficiency as titanium dioxide.

[0006] To achieve the above-mentioned object of the invention, the technical solution of the present invention is as follows:

[0007] On the one hand, the present invention provides a novel titanium-free light-shielding soft capsule material, and its technical solution is as follows:

[0008] The capsule material comprises the following components by weight percentage:

[0009] Gelatin 35-45%; Glycerin 15-23%; Purified water 30-40%; Composite calcium carbonate 3-5%; Emulsifier 0.5-0.7%; Pigment 0-2%;

[0010] Wherein, the composite calcium carbonate includes light calcium carbonate and heavy calcium carbonate.

[0011] Preferably, the mass fraction of the light calcium carbonate in the composite calcium carbonate is 90-99.5%, and the mass fraction of the heavy calcium carbonate in the composite calcium carbonate is 0.5-10%.

[0012] Further preferably, the mesh size of the light calcium carbonate is 2000-3000 mesh, and the mesh size of the heavy calcium carbonate is 2000-3000 mesh.

[0013] Preferably, the weight ratio of the composite calcium carbonate to the emulsifier is 4-10:1.

[0014] Preferably, the emulsifier is selected from one or more of mono- and di-glycerol fatty acid esters, polyglycerol fatty acid esters, and propylene glycol fatty acid esters.

[0015] Further preferably, it is characterized in that the emulsifier is polyglycerol fatty acid ester.

[0016] Preferably, it is characterized in that the pigment is selected from one or more of caramel, carmine, sunset yellow and lemon yellow.

[0017] In yet another aspect, the present invention provides application of the soft capsule material in food and medicine.

[0018] Specifically, the food includes ordinary food and health food.

[0019] In another aspect, the present invention provides a method for preparing a soft capsule material, comprising the following steps:

[0020] (1) Pretreatment of composite calcium carbonate: Mix composite calcium carbonate with glycerol, pass through a colloid mill, grind, and pass through a 60-200 mesh sieve to obtain a composite calcium carbonate premix for later use.

[0021] (2) Gelatinization: Add purified water, pigment, and emulsifier into the equipment, stir, heat to 73-77°C, and evacuate. Add gelatin, mix evenly, and continue to evacuate to reach the required viscosity.

[0022] (3) Adding composite calcium carbonate premix: After the above sol is completed, add composite calcium carbonate premix, confirm that the mixture is evenly mixed, and continue to evacuate until the vacuum degree reaches -0.07 MPa or above, and evacuate for 1 to 15 minutes. Stop stirring and continue evacuating for another 1 to 15 minutes.

[0023] (4) Glue output: After the above steps are completed, the glue liquid is filtered and stored in an insulated barrel.

[0024] Finally, the present invention provides a soft capsule and a preparation method thereof, which comprises contents and the soft capsule material, wherein the soft capsule material is used for wrapping the contents.

[0025] Preferably, the contents include one or more of DHA algae oil, fish oil, β-carotene oil, linseed oil, walnut oil, soybean oil, cod liver oil, coconut oil, krill oil, zeaxanthin oil, lutein, propolis, lutein esters, anthocyanins, vitamin E, vitamin D, vitamin A, B vitamins, vitamin K, blueberry extract, wolfberry extract, bilberry extract, grape seed extract, blackcurrant extract, and mineral salts. The method for preparing the soft capsule is characterized by comprising the following steps:

[0026] (1) Pretreatment of composite calcium carbonate: Mix composite calcium carbonate with glycerol, pass through a colloid mill, grind, and pass through a 60-200 mesh sieve to obtain a composite calcium carbonate premix for later use.

[0027] (2) Gelatinization: Add purified water, pigment, and emulsifier into the equipment, stir, heat to 73-77°C, and evacuate. Add gelatin, mix evenly, and continue to evacuate to reach the required viscosity.

[0028] (3) Adding composite calcium carbonate premix: After the above sol is completed, add composite calcium carbonate premix, confirm that the mixture is evenly mixed, and continue to evacuate until the vacuum degree reaches -0.07 MPa or above, and evacuate for 1 to 15 minutes. Stop stirring and continue evacuating for another 1 to 15 minutes.

[0029] (4) Glue output: After the above steps are completed, the glue liquid is filtered and stored in an insulated barrel.

[0030] (5) Pill pressing: Use the above-prescribed gelatin solution, quantitatively supply it to a soft capsule pressing machine, and quantitatively supply the contents to produce suitable soft capsules.

[0031] (6) Drying and pill selection: The soft capsules are dried and pilled after the hardness reaches the required standard. The capsules are placed on a light inspection table and unqualified capsules such as those with oil leakage, empty rubber, irregular shapes, bubbles, black spots, etc. are selected. The capsules are then packaged after pill selection.

[0032] (7) Packaging: Select appropriate inner packaging materials for packaging.

[0033] The beneficial effects of the present invention are:

[0034] (1) The present invention can achieve light shielding properties equivalent to those of titanium dioxide by adding light calcium carbonate and heavy calcium carbonate in a specific ratio to the capsule material and mixing them with an emulsifier in a suitable ratio. The prepared soft capsule has good shielding properties, is not affected by the color depth of the contents, is not color-transparent, can effectively protect light-sensitive contents under strong light inspection, and avoids stratification and degradation of light-sensitive contents, and has good stability.

[0035] (2) The soft capsule preparation method of the present invention has a simple process, a mature production process, high practicability, and is conducive to large-scale commercial production of the product.

[0036] (3) The sun-shielding soft capsules of the present invention avoid the addition of the traditional sun-shielding agent titanium dioxide, reduce the potential health risks of titanium dioxide, reduce the pollution and adverse effects of titanium dioxide on the natural environment, and provide a greener, healthier and more environmentally friendly sun-shielding solution. DETAILED DESCRIPTION

[0037] In order to make the technical means, creative features, purpose and efficacy of the present invention easy to understand, the present invention is further explained in conjunction with specific embodiments below, but the following embodiments are only preferred embodiments of the present invention, not all. Based on the embodiments in the implementation mode, other embodiments obtained by those skilled in the art without creative work belong to the protection scope of the present invention. It should also be understood that the terms used in the embodiments of the present invention are to describe specific embodiments, not to limit the protection scope of the present invention.

[0038] In the following examples, unless otherwise specified, the operating methods used are conventional operating methods, and the equipment used are conventional equipment. Unless otherwise specified, % in the present invention represents mass percentage. Unless otherwise specified, the raw materials used in the present invention are all common commercial products in the technical field. When the embodiments give numerical ranges, it should be understood that, unless otherwise specified in the present invention, the two endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those generally understood by those of ordinary skill in the technical field to which the present invention belongs.

[0039] Inspection of light-shielding soft capsule materials

[0040] Example

[0041] 1. A novel titanium-free light-shielding soft capsule material, the formula components of each embodiment are shown in Table 1 (all calculated by mass percentage):

[0042] Gelatin 35-45%; Glycerin 15-23%; Purified water 30-40%; Composite calcium carbonate 3-5%; Emulsifier 0.5-0.7%; Pigment 0-2%;

[0043] The composite calcium carbonate includes light calcium carbonate and heavy calcium carbonate. The mass fraction of the light calcium carbonate in the composite calcium carbonate is 90-99.5%, and the mass fraction of the heavy calcium carbonate in the composite calcium carbonate is 0.5-10%.

[0044] The mesh size of the light calcium carbonate is 2000-3000 mesh, and the mesh size of the heavy calcium carbonate is 2000-3000 mesh.

[0045] Table 1 Formula composition of capsule material composition of Examples 1-9

[0046]

[0047]

[0048] 2. The preparation process of the soft capsule material is as follows:

[0049] (1) Pretreatment of composite calcium carbonate: Mix composite calcium carbonate with glycerol, pass through a colloid mill, grind, and pass through a 60-200 mesh sieve to obtain a composite calcium carbonate premix for later use.

[0050] (2) Gelatinization: Add purified water, caramel color, and polyglycerol fatty acid ester into a gelatinization bucket, stir, heat to 77°C, and evacuate. Add gelatin, mix evenly, and continue evacuating until the desired viscosity is reached.

[0051] (3) Adding composite calcium carbonate premix: After the above sol is completed, add composite calcium carbonate premix, confirm that the mixture is evenly mixed, and continue to evacuate until the vacuum degree reaches -0.07 MPa or above, and evacuate for 1 to 15 minutes. Stop stirring and continue evacuating for another 1 to 15 minutes.

[0052] (4) Glue dispensing: After the above steps are completed, filter the glue solution, keep it warm for 60 minutes, and then spread the glue.

[0053] 3. Detection

[0054] The soft capsule material prepared above was evaluated for gelling and appearance of the rubber skin and tested for light transmittance.

[0055] Light transmittance detection: The detection uses a digital fiber optic sensor, which can feedback the light transmittance through the rubber in the form of a specific value. The specific method is: turn on the light transmittance tester, power on for 1 minute, place the rubber on the fixed clamp, push the light transmittance tester, wait for 10 seconds, start reading, repeat the measurement 3 times, and take the average value.

[0056] Comparative Example

[0057] 1. A light-shielding soft capsule material, the formula components of each comparative example are shown in Table 2 (all calculated by mass percentage):

[0058] Table 2 Comparative Examples 1-14 Capsule Material Composition Formula Composition

[0059]

[0060]

[0061] 2. The preparation process of the soft capsule material is as follows:

[0062] (1) Pretreatment of sunscreen agent: mix the sunscreen agent with glycerin, pass through a colloid mill, grind, and pass through a 60-200 mesh screen to obtain a sunscreen agent premix for later use. (The sunscreen agent in Comparative Examples 1-9 is composite calcium carbonate; the sunscreen agent in Comparative Example 10 is titanium dioxide; the sunscreen agent in Comparative Examples 11-12 is heavy calcium carbonate; the sunscreen agent in Comparative Examples 13-14 is light calcium carbonate)

[0063] (2) Gelatinization: Add purified water, caramel color, and polyglycerol fatty acid ester (if any) into the equipment, stir, heat to 77°C, and evacuate. Add gelatin, mix well, and continue to evacuate to reach the required viscosity.

[0064] (3) Adding the sunscreen premix: After the above sol is completed, add the sunscreen premix. After confirming that the mixture is evenly mixed, the vacuum degree reaches -0.07 MPa, and continue to evacuate. The vacuum degree must reach above -0.07 MPa, and evacuate for 1 to 15 minutes. Stop stirring and continue evacuating for another 1 to 15 minutes.

[0065] (4) Glue dispensing: After the above steps are completed, filter the glue solution, keep it warm for 60 minutes, and then spread the glue.

[0066] 3. Detection

[0067] The prepared glue liquidization, glue spreading process (customized glue spreading board, thickness 0.8mm), and appearance of the rubber were evaluated, and the transmittance test was carried out.

[0068] Light transmittance detection: The detection uses a digital fiber optic sensor, which can feedback the light transmittance through the rubber in the form of a specific value. The specific method is: turn on the light transmittance tester, power on for 1 minute, place the rubber on the fixed clamp, push the light transmittance tester, wait for 10 seconds, start reading, repeat the measurement 3 times, and take the average value.

[0069] Test results

[0070] Taking “gel liquidization condition”, “gel spreading condition”, “gel skin appearance condition” and “light transmittance” as indicators, the results of the soft capsule material inspection experiment are shown in Tables 3 and 4.

[0071] Table 3: Test results of capsule making and capsule material rubber of Examples 1-9

[0072]

[0073]

[0074] Note: The product light transmittance data is lower than 280, and the product light transmittance probability is low

[0075] The results are shown in Table 3: The glue liquidization process of Examples 1-9 generally showed the characteristics of uniformity and dispersibility; in terms of the appearance of the rubber, all Examples had no color spots and uniform color; in terms of transmittance, the transmittance data of all Examples were lower than 280, indicating that the product had a low probability of light transmission and a good shading effect.

[0076] Table 4: Test results of capsule making and capsule material rubber in Examples 1-14

[0077]

[0078] Note: The product light transmittance data is lower than 280, and the product light transmittance probability is low

[0079] As shown in Table 4, comparative example 10 uses titanium dioxide as a sunscreen, and the rubber is easily dispersed during the glue-making process, and the rubber appearance has no color spots and is uniform in color, and the light transmittance is 220, which is close to the results of each embodiment. The other comparative examples show greater differences in the glue-making process, glue-laying process, rubber appearance and light transmittance. Specifically:

[0080] The influence of the sunscreen in the capsule material composition on the measurement results was investigated: when the mass fraction of the composite calcium carbonate in the capsule material composition was not within the range of 3-5%, when the content was high (Comparative Example 7), the rubber had slight color spots and uneven color, and when the content was low (Comparative Example 8), the rubber was transparent and uneven in color. When the mass fractions of light calcium carbonate and heavy calcium carbonate in the composite calcium carbonate did not fall within the range described in the present invention, the proportion of light calcium carbonate decreased (Comparative Example 1) and the rubber was transparent, and when the proportion of light calcium carbonate increased (Comparative Example 2), the rubber was transparent, calcium carbonate was difficult to disperse during the gelling process, and the transmittance results of the two groups were both greater than 280, and the shading effect was poor. When only heavy calcium carbonate is used as a sunshade, the rubber is translucent and the light transmittance is significantly increased without any sunshade effect (Comparative Examples 11 and 12); when only light calcium carbonate is used as a sunshade, although the sunshade rate is lower than 280, color spots appear on the rubber and calcium carbonate is difficult to disperse during the gelling process, which is not conducive to the preparation of the rubber and the subsequent gluing process (Comparative Examples 13 and 14).

[0081] The effect of the emulsifier in the capsule material composition on the measurement results was investigated: when the emulsifier content in the composition was too low (Comparative Example 5), calcium carbonate was difficult to disperse during the gelling process, and color spots appeared on the prepared rubber; when the emulsifier content in the composition was too high (Comparative Example 6), the glue was viscous and it was difficult to spread the glue. When the ratio of the sunscreen agent to the emulsifier in the composition exceeded the scope of the present invention, compared with the emulsifier, when the sunscreen content was too low (Comparative Example 3), the prepared rubber had obvious color transparency, uneven color, and a transmittance significantly higher than 280; when the sunscreen content was too high (Comparative Example 4), a large number of color spots appeared on the rubber and the glue was not spread smoothly. When no emulsifier was added (Comparative Example 9), the rubber had a color transparency phenomenon, uneven color, a transmittance of 312, and a poor light shielding effect.

[0082] Light-shielding soft capsule inspection

[0083] Based on the experimental results of the above soft capsule material investigation, the capsule material formulas of Example 1, Example 4, Example 9, Comparative Example 2 and Comparative Example 10 were selected to prepare soft capsules.

[0084] 1. Soft capsule materials. The formula components of five groups of capsule materials are shown in Table 5 (all calculated by mass percentage):

[0085] Table 5

[0086]

[0087] 2. Provide two types of soft capsules with different contents. One is vitamin K2 soft capsules, whose contents are all oily and mutually soluble. The other is lutein and zeaxanthin soft capsules. The contents include lutein, zeaxanthin, zinc citrate and other oil-insoluble ingredients, and beeswax is required to be used for suspension. The content is a suspension. The production and processing technology of the soft capsules mainly includes the following steps:

[0088] Rubber preparation:

[0089] (1) Pretreatment of composite calcium carbonate or titanium dioxide: Mix composite calcium carbonate or titanium dioxide with glycerol, pass through a colloid mill, grind, and pass through a 60-200 mesh sieve to obtain a composite calcium carbonate or titanium dioxide premix for later use.

[0090] (2) Gelatinization: Add purified water, caramel color, and polyglycerol fatty acid ester (if any) into the equipment, stir, heat to 77°C, and evacuate. Add gelatin, mix evenly, and continue to evacuate to reach the required viscosity.

[0091] (3) Adding composite calcium carbonate or titanium dioxide premix: After the above sol is completed, add composite calcium carbonate or titanium dioxide premix, confirm that the mixture is evenly mixed, and the vacuum degree reaches -0.07MPa. Continue to vacuumize. The vacuum degree must reach above -0.07MPa and vacuumize for 1 to 15 minutes. Stop stirring and continue to vacuumize for 1 to 15 minutes.

[0092] (4) Glue output: After the above steps are completed, the glue liquid is filtered and stored in an insulated barrel.

[0093] Contents preparation:

[0094] Vitamin K2 soft capsules: Weigh vitamin K2 oil and soybean oil according to the formula, mix well and set aside.

[0095] Lutein zeaxanthin soft capsule: Add zinc gluconate, selenium-enriched yeast, lutein oil, vitamin E (d-α-tocopherol acetate), (3R, 3'S)-dihydroxy-β-carotene oil, (3R, 3'R)-dihydroxy-β-carotene oil, vitamin A oil, soybean oil, beeswax (beeswax needs to be heated to 60-75°C when added) according to the formula, and stir for 30-120 minutes. Filter the liquid to 60-200 mesh.

[0096] (5) Pill pressing: Use the above-prescribed gelatin solution to supply it to a soft capsule pill pressing machine, feed the contents quantitatively, and encapsulate the capsules into pills.

[0097] (6) Drying and pill selection: The soft capsules are dried and pilled after the hardness reaches the required standard. The capsules are placed on a light inspection table and unqualified capsules such as those with oil leakage, empty rubber, irregular shapes, bubbles, black spots, etc. are selected. The capsules are then packaged after pill selection.

[0098] (7) Packaging: Select appropriate inner packaging materials for packaging.

[0099] 3. Detection

[0100] According to the characteristics of the above two soft capsules, strong light irradiation test was used to examine the protective effect of the rubber on the photosensitivity component vitamin K2 in the contents. In addition, high temperature test was used to place the lutein and zeaxanthin soft capsules in a high temperature environment of 50°C to observe whether the stratification of the contents can be seen through the rubber after the beeswax melted and thinned.

[0101] Strong light irradiation test: The prepared vitamin K2 soft capsules were placed under strong light conditions (4500lx±500lx, 25°C), and samples were taken on 5, 10, and 15 days respectively to determine the content of K2 in the contents. The K2 content determined before the start of the experiment was used as a benchmark to observe the changes in the content of K2 in the contents.

[0102] High temperature test: The prepared lutein and zeaxanthin soft capsules were placed at 50°C for 3 days to observe whether the stratification of the contents could be observed through the rubber layer.

[0103] Table 6 Vitamin K2 soft capsule test results

[0104]

[0105] Table 7 Lutein and zeaxanthin soft capsule test results

[0106]

[0107] By comparing the test results of Table 6 and Table 7, it can be seen that the Example 4 group, the Example 9 group, and the Comparative Example 10 group have basically the same function in preventing the attenuation of the photosensitive component vitamin K2 and covering the stratification of the contents. The Example 1 group is slightly inferior in effect, but can still meet the shielding requirements. The Example 1 group, the Example 4 group, and the Example 9 group can all meet the company's existing production line in terms of production compliance, without the need to add new soft capsule production equipment. The light stability test results show that the vitamin K2 content of the contents of each group of soft capsules under strong light irradiation decreases over time, but the decline is smaller than that of the Comparative Example 2 group, and the contents can be effectively protected from light, indicating that the shading performance of each embodiment group is equivalent to that of the Comparative Example 10 group, and each embodiment group can effectively prevent the attenuation of the photosensitive components under strong light irradiation. The high temperature investigation test results of lutein zeaxanthin soft capsules show that the stratification of the contents of lutein zeaxanthin soft capsules caused by high temperature placement can be well covered in each embodiment group and the Comparative Example 10 group, thereby ensuring the appearance stability of the capsule under high temperature extreme environment. In summary, the capsule material formula used in the present invention provides a new and efficient solution for the preparation of light-shielding soft capsules, and achieves the same effect as when titanium dioxide is used as a light-shielding agent in terms of shielding, stability and production efficiency. It provides a new idea for the development of titanium-free light-shielding soft capsule products.

Claims

1. A novel titanium-free light-shielding soft capsule material, characterized in that: The capsule material comprises the following components by weight percentage: Gelatin 35-45%; Glycerin 15-23%; Purified water 30-40%; Composite calcium carbonate 3-5%; Emulsifier 0.5-0.7%; Pigment 0-2%; Wherein, the composite calcium carbonate includes light calcium carbonate and heavy calcium carbonate.

2. The soft capsule material according to claim 1, characterized in that: The mass fraction of the light calcium carbonate in the composite calcium carbonate is 90-99.5%, and the mass fraction of the heavy calcium carbonate in the composite calcium carbonate is 0.5-10%.

3. The soft capsule material according to claim 2, characterized in that: The mesh size of the light calcium carbonate is 2000-3000 mesh, and the mesh size of the heavy calcium carbonate is 2000-3000 mesh.

4. The soft capsule material according to any one of claims 1 to 3, characterized in that: The weight ratio of the composite calcium carbonate to the emulsifier is 4-10:

1.

5. The soft capsule material according to claim 4, characterized in that: The emulsifier is selected from one or more of monoglycerol fatty acid esters, diglycerol fatty acid esters, polyglycerol fatty acid esters, and propylene glycol fatty acid esters; preferably, the emulsifier is polyglycerol fatty acid esters.

6. The soft capsule material according to claim 1, characterized in that The pigment is selected from one or more of caramel, carmine, sunset yellow and lemon yellow.

7. Use of the soft capsule material according to any one of claims 1 to 6 in the preparation of food and medicine.

8. The method for preparing the soft capsule material according to any one of claims 1 to 6, characterized in that: The method comprises the following steps: (1) Pretreatment of composite calcium carbonate: Mix composite calcium carbonate with glycerol, pass through a colloid mill, grind, and pass through a 60-200 mesh sieve to obtain a composite calcium carbonate premix for standby use; (2) Gelatinization: Purified water, pigment, and emulsifier are added into the equipment and stirred, heated to 73-77°C, vacuumed, and gelatin is added. After mixing evenly, vacuumization is continued to reach the required viscosity; (3) Adding the composite calcium carbonate premix: After the gelling step (2) is completed, add the composite calcium carbonate premix, confirm that the mixture is uniformly mixed, and then evacuate the mixture while stirring to ensure that the vacuum degree reaches above -0.07 MPa. Vacuum the mixture for 1 to 15 minutes, stop stirring, and continue evacuating the mixture for another 1 to 15 minutes; (4) Glue discharge: After step (3) is completed, the glue solution is filtered and stored in a heat-insulating barrel.

9. A soft capsule, characterized in that: The soft capsule comprises contents and the soft capsule material according to any one of claims 1 to 6, wherein the capsule material is used to wrap the contents, and the contents comprise one or more of DHA algae oil, fish oil, β-carotene oil, linseed oil, walnut oil, soybean oil, cod liver oil, coconut oil, zeaxanthin oil, krill oil, lutein, propolis, lutein esters, anthocyanins, vitamin E, vitamin D, vitamin A, B vitamins, vitamin K, blueberry extract, wolfberry extract, bilberry extract, grape seed extract, blackcurrant extract, and mineral salts.

10. The method for preparing the soft capsule according to claim 9, characterized in that: The following steps are involved: (1) Pretreatment of composite calcium carbonate: Mix composite calcium carbonate with glycerol, pass through a colloid mill, grind, and pass through a 60-200 mesh sieve to obtain a composite calcium carbonate premix for standby use; (2) Gelatinization: Purified water, pigment, and emulsifier are added into the equipment and stirred, heated to 73-77°C, vacuumed, and gelatin is added. After mixing evenly, vacuumization is continued to reach the required viscosity; (3) Adding the composite calcium carbonate premix: After the gelling step (2) is completed, add the composite calcium carbonate premix, confirm that the mixture is uniformly mixed, and then evacuate the mixture while stirring to ensure that the vacuum degree reaches above -0.07 MPa. Vacuum the mixture for 1 to 15 minutes, stop stirring, and continue evacuating the mixture for another 1 to 15 minutes; (4) Glue discharge: After step (3) is completed, the glue solution is filtered and stored in a heat preservation barrel; (5) Pill pressing: The gelatin solution prepared in step (4) is quantitatively supplied to a soft capsule pill pressing machine, and the contents are quantitatively supplied to produce suitable soft capsules.

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