Polysaccharide CWP-3 extracted from curcuma zedoary as well as preparation method and application of polysaccharide CWP-3

By separating the acidic polysaccharide CWP-3 from the medicinal materials of fermented fermentation or the residue after extracting volatile oil, the problem of the residue not being effectively utilized after extracting volatile oil in fermentation was solved, and the efficient preparation of homogeneous polysaccharides with antioxidant and anti-blood stasis effects was achieved.

CN119684483AActive Publication Date: 2025-03-25SHENYANG PHARMA UNIV
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Patent Information

Application Number
CN202411890880.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-20
Publication Date
2025-03-25
Estimated Expiration
2044-12-20

AI Technical Summary

Technical Problem

In the prior art, the remaining medicine residues after extracting volatile oils in zedoaria zedoaria have not been effectively utilized, and the structure and activity of polysaccharides in zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria zedoaria ze

Method used

The acidic polysaccharide CWP-3 obtained was isolated from the medicinal herbs after extracting volatile oil from the medicinal herbs or the residue after extracting volatile oil. The homogeneous medicinal herbs such as ethanol reflux degreasing, amylase treatment, Sevage reagent protein removal, alcohol precipitation and freeze-drying were prepared.

Benefits of technology

CWP-3 has good homogeneity, a molecular weight of 400-1000 kDa, and its monosaccharide composition includes Rha, GalA, Gal and Ara. It has a distinct three-strand helical structure, showing significant antioxidant and anti-blood stasis effects.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine polysaccharide development, and particularly relates to an active polysaccharide CWP-3 extracted from curcuma zedoary medicinal materials or medicine residues obtained after volatile oil is extracted from the curcuma zedoary medicinal materials, and a preparation method and application of the active polysaccharide CWP-3. The obtained homogeneous polysaccharide CWP-3 is heteropolysaccharide, monosaccharides comprise rhamnose (Rha), galacturonic acid (GalA), galactose (Gal) and arabinose (Ara), the molecular weight is 400-1000 kDa, the variety and the connection mode of sugar residues are measured by adopting multiple analysis technologies such as HPLC (High Performance Liquid Chromatography), FTIR (Fourier Transform Infrared Spectroscopy), GC-MS (Gas Chromatography-Mass Spectrometry) and NMR (Nuclear Magnetic Resonance), and the analysis of an AFM (Atomic Force Microscope) shows that the CWP-3 has an obvious triple helical structure. In addition, pharmacological experiments show that CWP or CWP-3 has good effects of resisting oxidation and treating blood stasis syndromes, cardiovascular diseases, dysmenorrhea and functional constipation.
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Citation Information

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