Preparation method of medicine for treating kidney diseases

Abstract

The invention discloses a preparation method of a medicine for treating kidney diseases. The medicine comprises the following raw materials in parts by weight: 10-15 parts of astragalus membranaceus, 8-12 parts of salvia miltiorrhiza, 6-10 parts of angelica sinensis, 3-5 parts of cinnamon, 4-8 parts of safflower carthamus, 6-10 parts of bamboo leaves, 8-12 parts of artemisia apiacea, 4-6 parts of junci medulla, 6-10 parts of sculellaria barbata, 6-20 parts of pyrrosia lingua, 5-10 parts of honeysuckle, 6-12 parts of fructus forsythiae, 8-15 parts of poria cocos, 4-6 parts of liquorice, 4-6 parts of radix angelicae pubescentis, 4-6 parts of radix ginseng rubra, 4-6 parts of decaisnea insignis and 4-6 parts of Qianju. , 4-6 parts of Chinese yam, 4-6 parts of turtle shell and 4-6 parts of burdock; the traditional Chinese medicine composition has the beneficial effects that the medicine formula is more optimized, various Chinese herbal medicine raw materials with the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis and the like are selected, and the curative effect and safety of the medicine are improved through scientific compatibility; the preparation method is more perfect, and effective components in the Chinese herbal medicines are effectively extracted through the steps of crushing, decocting, concentrating, drying and the like.

Description

Technical Field

[0001] The invention belongs to the technical field of drug preparation, and in particular relates to a method for preparing a drug for treating kidney disease. Background Art

[0002] Some kidney diseases have a genetic tendency, such as polycystic kidney disease, which will directly affect the normal function of the kidneys and increase the risk of other family members getting sick. Long-term intake of excessive salt, high-fat foods, and high-salt foods such as pickles and pickled meats will increase the burden on the kidneys and may lead to diseases such as high blood pressure, which in turn causes kidney disease. Long-term sitting and lack of physical exercise will lead to slower metabolism and fat accumulation, which can easily lead to chronic diseases such as obesity, high blood pressure, and diabetes, all of which may lead to kidney disease. Smoking and excessive drinking can damage the kidneys. Certain drugs and chemicals are toxic to the kidneys, and long-term use of these drugs or exposure to these chemicals may cause kidney damage. Long-term high blood sugar and high blood pressure can damage the microvessels and arterioles of the kidneys, leading to diabetic nephropathy and hypertensive nephropathy. Active treatment can significantly slow the progression of the disease. Treatment can effectively alleviate the patient's symptoms and improve the quality of life.

[0003] Patent publication number CN101099809B is a drug for treating kidney disease and its preparation method. The patent discloses that it is a drug prepared from the following raw materials in weight ratio: 1-15 astragalus, 6-20 pyrrosia, 6-20 acanthus, 6-15 blue cloth, 3-12 water centipede, 10-30 lianqiancao, 6-20 polygonum capitatum, 8-25 kudzu root, 3-10 honeysuckle, 4-20 madder, 4-15 tangerine peel; the preparation method is as follows: add water to the above eleven medicinal materials and decoct them twice, add 8 times the amount of water for the first time, soak for 2 hours, then boil for 30 minutes, and filter; add 6 times the amount of water for the second time volume, then boil for 30 minutes and filter; combine the two filtrates, concentrate under reduced pressure to about 2 / 3 volume, the relative density at 60°C is 1.01-1.02, let stand for 4-6 hours, filter the supernatant, and then concentrate under reduced pressure to a relative density of 1.15-1.18 at 60°C, spray dry to obtain dry extract powder; take 1 part of dry extract powder, add 1 part of dextrin, mix well, add 15-25% ethanol according to the amount of mixed materials, the ethanol concentration is 60-80%, make wet granules, dry, granulate, and make granule products. Although this patent can delay the progression of the disease and alleviate symptoms, the efficacy and safety still need to be improved. Summary of the invention

[0004] The purpose of the present invention is to provide a method for preparing a medicine for treating kidney disease, which has more reliable efficacy, higher safety and no obvious toxic and side effects.

[0005] To achieve the above object, the present invention provides the following technical solution: a method for preparing a drug for treating kidney disease, comprising the following steps:

[0006] The invention is composed of the following raw materials in weight ratio: 10-15 parts of astragalus, 8-12 parts of salvia miltiorrhiza, 6-10 parts of angelica, 3-5 parts of cinnamon, 4-8 parts of safflower, 6-10 parts of bamboo leaves, 8-12 parts of artemisia annua, 4-6 parts of rush, 6-10 parts of barbata, 6-20 parts of pyrrosia, 5-10 parts of honeysuckle, 6-12 parts of forsythia, 8-15 parts of tuckahoe, 4-6 parts of liquorice, 4-6 parts of angelica pubescens, 4-6 parts of American ginseng, 4-6 parts of cat feces, 4-6 parts of qianwengu, 4-6 parts of yam, 4-6 parts of turtle shell, and 4-6 parts of burdock fruit;

[0007] The above Chinese herbal medicine raw materials are crushed separately and mixed evenly;

[0008] The mixed Chinese herbal medicine raw materials are boiled in water twice and filtered;

[0009] Combine the two filtrates, and concentrate under reduced pressure to obtain a concentrate;

[0010] The concentrated solution was allowed to stand, the supernatant was filtered out, and the solution was concentrated again under reduced pressure to obtain an extract;

[0011] treating the extract to obtain dry extract powder;

[0012] Take the dry extract powder, add auxiliary materials, mix well and make into capsule dosage form.

[0013] As a preferred technical solution of the present invention, the mixed Chinese herbal medicine raw materials are decocted with water twice, the first time the amount of water added is 8 to 10 times the weight of the raw materials, soaking for 1.2 to 1.6 hours, then boiling for 0.6 to 0.8 hours, and filtering; the second time the amount of water added is 4 to 6 times the weight of the raw materials, boiling for 0.8 to 1.2 hours, and filtering.

[0014] As a preferred technical solution of the present invention, the two filtrates are combined and concentrated under reduced pressure to 1 / 3 to 1 / 2 of the original volume to obtain a concentrated solution.

[0015] As a preferred technical solution of the present invention, the concentrated solution is allowed to stand for 2 to 4 hours, the supernatant is filtered out, and the solution is concentrated under reduced pressure again to obtain an extract.

[0016] As a preferred technical solution of the present invention, the method of reduced pressure concentration is as follows:

[0017] Pour the combined two filtrates into a vacuum concentration device;

[0018] Connect the condenser and the receiving bottle to ensure that the device is well sealed;

[0019] Open the vacuum equipment to reduce the system pressure and make the liquid medicine start to boil at low temperature;

[0020] Control the heating temperature and time to gradually concentrate the drug solution to the required volume;

[0021] During the concentration process, observations were made and operating parameters were adjusted;

[0022] After concentration is completed, turn off the heating and exhaust equipment, and take out the drug solution after it cools down.

[0023] As a preferred technical solution of the present invention, during the concentration process, the temperature, pressure and concentration degree of the drug solution are observed and the operating parameters are adjusted.

[0024] As a preferred technical solution of the present invention, the extract is spray-dried to obtain dry extract powder.

[0025] As a preferred technical solution of the present invention, the auxiliary material is dextrin.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] The drug formula is more optimized, and a variety of Chinese herbal medicines with the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis are selected. Through scientific compatibility, the efficacy and safety of the drug are improved;

[0028] The preparation method is more perfect. Through the steps of crushing, decoction, concentration, drying, etc., the active ingredients in Chinese herbal medicine are effectively extracted to ensure the quality and stability of the medicine.

[0029] The finished drug product has significant efficacy and safety, has no obvious toxic side effects, and is suitable for the treatment of various kidney diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 The present invention is a flow chart of the method for preparing the medicine. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0032] Example 1

[0033] See also Figure 1 , which is the first embodiment of the present invention, provides a method for preparing a drug for treating kidney disease, comprising the following steps:

[0034] The invention is composed of the following raw materials in weight ratio: 10 parts of astragalus, 8 parts of salvia miltiorrhiza, 6 parts of angelica, 3 parts of cinnamon, 4 parts of safflower, 6 parts of bamboo leaf, 8 parts of artemisia annua, 4 parts of rush, 6 parts of barbata, 6 parts of pyrrosia, 5 parts of honeysuckle, 6 parts of forsythia, 8 parts of tuckahoe, 4 parts of liquorice, 4 parts of angelica pubescens, 4 parts of American ginseng, 4 parts of cat feces, 4 parts of qianwengu, 4 parts of yam, 4 parts of turtle shell, and 4 parts of burdock fruit;

[0035] The above Chinese herbal medicine raw materials are crushed separately and mixed evenly;

[0036] The mixed Chinese herbal medicine raw materials were decocted twice with water. The first time, the amount of water added was 8 times the weight of the raw materials, soaked for 1.2 hours, then boiled for 0.6 hours, and filtered; the second time, the amount of water added was 4 times the weight of the raw materials, boiled for 0.8 hours, and filtered;

[0037] Combine the two filtrates, and concentrate under reduced pressure to 1 / 3 of the original volume to obtain a concentrate;

[0038] The concentrated solution was allowed to stand for 2 hours, the supernatant was filtered out, and concentrated again under reduced pressure to obtain an extract;

[0039] The extract is spray-dried to obtain dry extract powder;

[0040] Take the dry extract powder, add the auxiliary material dextrin, mix well and make it into capsule dosage form.

[0041] In this embodiment, preferably, the method of reduced pressure concentration is as follows:

[0042] Pour the combined two filtrates into a vacuum concentration device;

[0043] Connect the condenser and the receiving bottle to ensure that the device is well sealed;

[0044] Open the vacuum equipment to reduce the system pressure and make the liquid medicine start to boil at low temperature;

[0045] Control the heating temperature and time to gradually concentrate the drug solution to the required volume;

[0046] During the concentration process, observe the temperature, pressure and concentration level of the liquid medicine and adjust the operating parameters;

[0047] After concentration is completed, turn off the heating and exhaust equipment, and take out the drug solution after it cools down.

[0048] Astragalus is a tonic medicine that is good at replenishing qi. Astragalus is a medicine that replenishes qi and consolidates the exterior. It is used for spontaneous sweating and fatigue caused by exterior deficiency. It is also used for edema caused by qi deficiency. Astragalus has the effects of diuresis, detoxification, sore astringence and tissue regeneration. It is used to strengthen the spleen and stomach. Astragalus can prevent wounds from healing after ulcers break, and can play a role in sore astringence and tissue regeneration. It can be used to treat proteinuria caused by chronic nephritis.

[0049] Danshen can remove excess free radicals in the body and prevent free radical peroxidation, thereby achieving the effect of lowering blood sugar. In addition, Danshen also has antibacterial and anti-inflammatory effects, and has inhibitory effects on a variety of bacteria; it can promote liver cell regeneration and has anti-fibrosis effects, and can also inhibit inflammation and reduce liver cell degeneration and necrosis caused by inflammation; Danshen has a certain anti-tumor effect, can inhibit the central nervous system to a certain extent, and protect the body's health;

[0050] Angelica has a significant stimulating effect on the mononuclear macrophage system, and has an immune regulation and recovery effect on the body with low immune function; Angelica also promotes the transformation of lymphocytes in healthy people, and at the same time enhances the body's immunity; it has antispasmodic, anti-myocardial hypoxia, anti-arrhythmic, blood pressure lowering, blood lipid lowering, liver protection, anti-inflammatory analgesic, anti-bacterial and other effects;

[0051] Cinnamon is mainly used to treat diseases caused by insufficient kidney yang and cold uterus. Cinnamon has the effect of guiding fire back to the origin, and can treat diseases such as facial flushing, asthma, palpitations, insomnia, sweating, etc. caused by insufficient kidney yang and floating of false yang.

[0052] Safflower enters the heart, liver and blood, and has the properties of pungent, dispersing, warming and unblocking. It can invigorate blood circulation, relieve menstruation, dissipate blood stasis and relieve pain. When used with cinnamon bark, it can achieve the purpose of unblocking blood vessels.

[0053] The active ingredients of bamboo leaf extract include flavonoids, phenolic ketones, anthraquinones, lactones, polysaccharides, amino acids, trace elements, etc. It has excellent effects of anti-free radicals, anti-oxidation, anti-aging, anti-fatigue, lowering blood lipids, preventing cardiovascular and cerebrovascular diseases, protecting the liver, dilating capillaries, unblocking microcirculation, activating the brain, promoting memory, improving sleep, anti-cancer, beautifying the skin, etc.

[0054] Artemisia annua has the function of relieving fever and relieving pain. It contains a variety of nutrients and trace elements, which are beneficial to improving physical fitness, increasing the conversion rate of lymphocytes, and promoting the immune function of body cells.

[0055] Rush can promote diuresis, relieve stranguria, clear the heart and reduce internal heat;

[0056] Scutellaria barbata has the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and fighting cancer.

[0057] Pyrrosia contains alkaloids and glycosides, which have anti-inflammatory and bactericidal effects, can inhibit the activity of various bacteria in the human body and eliminate inflammation in the body;

[0058] Honeysuckle has the functions of clearing away heat, detoxifying, and dispersing wind-heat;

[0059] Forsythia has an inhibitory effect on many bacteria, such as Staphylococcus aureus, hemolytic Streptococcus, Pneumococcus, Pseudomonas aeruginosa, Salmonella typhi, Leptospira, etc.; it can promote the formation of inflammatory barriers and reduce the fragility of microvascular walls in inflammatory foci, thereby exerting an anti-inflammatory effect; the oleanolic acid in Forsythia has a cardiotonic effect, and Forsythia can also lower blood pressure and improve microcirculation; Forsythia also has antipyretic, antiemetic, diuretic, and anti-liver damage effects;

[0060] Poria cocos has the functions of regulating immunity and protecting liver;

[0061] Licorice can clear away heat and detoxify;

[0062] Angelica dahurica, American ginseng, cat feces, quinquefolius, yam, turtle shell, and burdock seed are combined to enhance the kidney-nourishing properties.

[0063] Example 2

[0064] See also Figure 1 , which is the second embodiment of the present invention, is based on the previous embodiment, except that:

[0065] The invention is composed of the following raw materials in weight ratio: 13 parts of astragalus, 10 parts of salvia miltiorrhiza, 8 parts of angelica, 4 parts of cinnamon bark, 6 parts of safflower, 8 parts of bamboo leaf, 10 parts of artemisia annua, 5 parts of rush, 8 parts of barbata, 13 parts of pyrrosia, 8 parts of honeysuckle, 9 parts of forsythia, 12 parts of tuckahoe, 5 parts of liquorice, 5 parts of angelica pubescens, 5 parts of American ginseng, 5 parts of cat feces, 5 parts of qianwengu, 5 parts of yam, 5 parts of turtle shell, and 5 parts of burdock fruit;

[0066] The above Chinese herbal medicine raw materials are crushed separately and mixed evenly;

[0067] The mixed Chinese herbal medicine raw materials were decocted twice with water. The first time, the amount of water added was 9 times the weight of the raw materials, soaked for 1.4 hours, then boiled for 0.7 hours, and filtered; the second time, the amount of water added was 5 times the weight of the raw materials, boiled for 1.0 hours, and filtered;

[0068] The two filtrates were combined and concentrated under reduced pressure to 2 / 5 of the original volume to obtain a concentrate;

[0069] The concentrated solution was allowed to stand for 3 h, the supernatant was filtered out, and concentrated again under reduced pressure to obtain an extract.

[0070] Example 3

[0071] See also Figure 1 , which is the third embodiment of the present invention, is based on the previous embodiment, except that:

[0072] The invention is composed of the following raw materials in weight ratio: 15 parts of astragalus, 12 parts of salvia miltiorrhiza, 10 parts of angelica, 5 parts of cinnamon bark, 8 parts of safflower, 10 parts of bamboo leaf, 12 parts of artemisia annua, 6 parts of rush, 10 parts of barbata, 20 parts of pyrrosia, 10 parts of honeysuckle, 12 parts of forsythia, 15 parts of tuckahoe, 6 parts of liquorice, 6 parts of angelica pubescens, 6 parts of American ginseng, 6 parts of cat feces, 6 parts of qianwengu, 6 parts of yam, 6 parts of turtle shell, and 6 parts of burdock fruit;

[0073] The above Chinese herbal medicine raw materials are crushed separately and mixed evenly;

[0074] The mixed Chinese herbal medicine raw materials were decocted twice with water. The first time, the amount of water added was 10 times the weight of the raw materials, soaked for 1.6 hours, then boiled for 0.8 hours, and filtered; the second time, the amount of water added was 6 times the weight of the raw materials, boiled for 1.2 hours, and filtered;

[0075] Combine the two filtrates, and concentrate under reduced pressure to 1 / 2 of the original volume to obtain a concentrate;

[0076] The concentrated solution was allowed to stand for 4 h, the supernatant was filtered out, and concentrated again under reduced pressure to obtain an extract.

[0077] The following is the clinical trial data of the drug of the present invention:

[0078] A clinical trial was conducted on 100 patients with renal failure, of whom 20 were cured, accounting for 20%; 35 were significantly effective, accounting for 35%; 20 were effective, accounting for 20%; 20 were stable, accounting for 20%; and 5 were ineffective, accounting for 5%.

[0079]

[0080]

[0081] Efficacy: By comparing the symptom improvement and disease progression rate of the two groups of patients, the patients in the drug preparation method of the present application showed higher efficacy;

[0082] Safety: The drug preparation method of this application has no obvious toxic side effects in clinical trials and is well tolerated by patients, while some patients in the background technology patents experienced mild adverse reactions;

[0083] Effective ingredient extraction rate: By optimizing the preparation method and extraction conditions, the drug preparation method of the present application can more efficiently extract the effective ingredients in Chinese herbal medicines and improve the quality of the drugs;

[0084] Drug stability: The drug prepared by the drug preparation method of the present application has higher stability and can maintain its efficacy during long-term storage, while the drug stability in the background art patent is average and special attention should be paid to moisture and heat protection;

[0085] Patient satisfaction: Through patient feedback surveys, patients with the drug preparation method of this application are more satisfied and willing to continue using it.

[0086] Although the embodiments of the present invention have been shown and described, as detailed above, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A method for preparing a drug for treating kidney disease, characterized in that: The steps include: The invention is composed of the following raw materials in weight ratio: 10-15 parts of astragalus, 8-12 parts of salvia miltiorrhiza, 6-10 parts of angelica, 3-5 parts of cinnamon, 4-8 parts of safflower, 6-10 parts of bamboo leaves, 8-12 parts of artemisia annua, 4-6 parts of rush, 6-10 parts of barbata, 6-20 parts of pyrrosia, 5-10 parts of honeysuckle, 6-12 parts of forsythia, 8-15 parts of poria, 4-6 parts of liquorice, 4-6 parts of angelica pubescens, 4-6 parts of American ginseng, 4-6 parts of cat feces, 4-6 parts of qianwengu, 4-6 parts of yam, 4-6 parts of turtle shell, and 4-6 parts of burdock fruit; The above Chinese herbal medicine raw materials are crushed separately and mixed evenly; The mixed Chinese herbal medicine raw materials are boiled in water twice and filtered; Combine the two filtrates, and concentrate under reduced pressure to obtain a concentrate; The concentrated solution was allowed to stand, the supernatant was filtered out, and the solution was concentrated again under reduced pressure to obtain an extract; treating the extract to obtain dry extract powder; Take the dry extract powder, add auxiliary materials, mix well and make into capsule dosage form.

2. A method for preparing a drug for treating kidney disease according to claim 1, characterized in that: The mixed Chinese herbal medicine raw materials are decocted with water twice. The first time, the amount of water added is 8 to 10 times the weight of the raw materials, soak for 1.2 to 1.6 hours, then boil for 0.6 to 0.8 hours, and filter. The second time, the amount of water added is 4 to 6 times the weight of the raw materials, boil for 0.8 to 1.2 hours, and filter.

3. The method for preparing a drug for treating kidney disease according to claim 1, characterized in that: The two filtrates were combined and concentrated under reduced pressure to 1 / 3 to 1 / 2 of the original volume to obtain a concentrated solution.

4. The method for preparing a drug for treating kidney disease according to claim 1, characterized in that: The concentrated solution was allowed to stand for 2 to 4 hours, the supernatant was filtered out, and concentrated under reduced pressure again to obtain an extract.

5. The method for preparing a drug for treating kidney disease according to claim 4, characterized in that: The method of reduced pressure concentration is as follows: Pour the combined two filtrates into a vacuum concentration device; Connect the condenser and the receiving bottle to ensure that the device is well sealed; Open the vacuum equipment to reduce the system pressure and make the liquid medicine start to boil at low temperature; Control the heating temperature and time to gradually concentrate the drug solution to the required volume; During the concentration process, observations were made and operating parameters were adjusted; After concentration is completed, turn off the heating and exhaust equipment, and take out the liquid medicine after it cools down.

6. The method for preparing a drug for treating kidney disease according to claim 5, characterized in that: During the concentration process, observe the temperature, pressure and concentration level of the drug solution and adjust the operating parameters.

7. The method for preparing a drug for treating kidney disease according to claim 1, characterized in that: The extract is spray dried to obtain dry extract powder.

8. The method for preparing a drug for treating kidney disease according to claim 1, characterized in that: The auxiliary material is dextrin.

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