A low molecular weight polysaccharide from sea grapes and a preparation method and application thereof

Abstract

The application aims to provide a Cystoseira low molecular weight polysaccharide and a preparation method and application thereof, which is prepared by fermentation of Cystoseira powder by Periconia sp. QAU-OG-Isz-15 with the preservation number of CGMCC No. 21455. The application effectively reduces the molecular weight of Cystoseira polysaccharide by microbial degradation, increases the content of functional polysaccharide, and further improves the anti-AD activity. In the in vitro experiment, compared with the undegraded Cystoseira polysaccharide, the Cystoseira low molecular weight polysaccharide has a more obvious inhibitory effect on Aβ 1‑42 aggregation, and in the C. elegans in vivo experiment, the Cystoseira low molecular weight polysaccharide has the effects of increasing the lifespan of C. elegans, delaying aging, and promoting the motor ability and reproductive ability of C. elegans, and has a significant inhibitory effect on Aβ 1‑42 aggregation. It is shown that the Cystoseira low molecular weight polysaccharide as a natural product ingredient has great potential in the development and application of new anti-AD therapeutic drugs and functional foods.

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