Medicine for treating body surface ulcer of freshwater aquarium fish caused by trauma and use method of medicine

Abstract

The invention discloses a medicine for treating body surface ulcer of freshwater aquarium fish caused by trauma and a use method of the medicine. Every 100 liters of water contains the following components: 0.07-0.09 ml of a povidone-iodine solution with the mass-volume ratio concentration of 10%, 0.75-1.5 g of oxytetracycline, 1.5-3.0 g of metronidazole and 0.1-0.2 g of chlorogenic acid. The sick fish is cultured in the treatment water, and the reprepared treatment water is slowly replaced every 6-12 hours until the sick fish is healed.

Description

Technical Field

[0001] The invention relates to the technical field of fish disease treatment, in particular to a medicine for treating freshwater ornamental fish body surface ulcers caused by trauma and a use method thereof. Background Art

[0002] Freshwater ornamental fish surface ulcers refer to ulcers caused by secondary bacterial infection on the fish surface due to trauma. Fighting during the breeding period, cosmetic surgery and mechanical damage during fishing can all cause trauma to the surface of the ornamental fish. Improper care can easily cause secondary bacterial infection, further developing into surface ulcers, threatening the life of the fish.

[0003] At present, the commonly used treatment methods are single antibiotic immersion and oral administration of antibiotic bait, which are not effective for fish with severe ulcers on the body surface, and the fish are easily infected with saprolegniasis during the treatment process. In summary, the existing treatment of ulcers on the body surface of freshwater ornamental fish has the problems of single medicine, poor efficacy, and the fish are easily infected with saprolegniasis during the treatment process. Summary of the invention

[0004] In view of the deficiencies in the prior art, the present invention provides a drug for treating surface ulcers of freshwater ornamental fish caused by trauma and a method of using the drug, which solves the problems of single drug, poor efficacy and easy infection of diseased fish with Saprolegniasis during the treatment process in the prior art.

[0005] In order to solve the above technical problems, the technical solution adopted by the present invention is: a medicine for treating surface ulcers of freshwater ornamental fish caused by trauma, containing the following ingredients per 100 liters of water: 0.07-0.09 ml of povidone-iodine solution with a mass volume concentration of 10%, 0.75-1.5 g of oxytetracycline, 1.5-3.0 g of metronidazole, and 0.1-0.2 g of chlorogenic acid.

[0006] The method for using the above-mentioned medicine for treating ulcers on the body surface of freshwater ornamental fish caused by trauma comprises the following steps:

[0007] (1) Take clean water after 24 hours of aeration, adjust the pH value and temperature to the suitable range for diseased ornamental fish, and continue aeration to maintain the dissolved oxygen concentration of the water at 5-8 mg / L;

[0008] (2) Add povidone iodine solution, oxytetracycline, metronidazole, and chlorogenic acid to the above clean water in proportion to prepare a treatment solution.

[0009] (3) Keep the sick fish in treatment water and slowly replace the reconfigured treatment water every 6-12 hours until the sick fish recovers.

[0010] The beneficial effects of the present invention are: the prevention effect of Saprolegniasis is enhanced by povidone iodine, and the inhibition of bacteria is enhanced by the drug combination of oxytetracycline, metronidazole and chlorogenic acid, so as to achieve the effect of treating ulcers on the surface of diseased fish. DETAILED DESCRIPTION

[0011] The technical solutions in the embodiments of the present invention are clearly and completely described below; it is obvious that the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments, and all other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making creative work are within the scope of protection of the present invention.

[0012] The drug for treating freshwater ornamental fish surface ulcers caused by trauma contains the following ingredients per 100 liters of water: 0.07-0.09 ml of a 10% mass volume concentration of povidone-iodine solution, 0.75-1.5 g of oxytetracycline, 1.5-3.0 g of metronidazole, and 0.1-0.2 g of chlorogenic acid.

[0013] The method for using the above-mentioned medicine for treating ulcers on the body surface of freshwater ornamental fish caused by trauma comprises the following steps:

[0014] (1) Take clean water after 24 hours of aeration, adjust the pH value and temperature to the suitable range for diseased ornamental fish, and continue aeration to maintain the dissolved oxygen concentration of the water at 5-8 mg / L;

[0015] (2) Add povidone iodine solution, oxytetracycline, metronidazole, and chlorogenic acid to the above clean water in proportion to prepare a treatment solution.

[0016] (3) Keep the sick fish in treatment water and slowly replace the reconfigured treatment water every 6-12 hours until the sick fish recovers.

[0017] Example 1

[0018] Breeding facilities: Three 375-liter glass fish tanks (1.5 meters long, 0.5 meters wide, and 0.5 meters high) are used as breeding containers, equipped with oxygen pumps for full-time oxygenation.

[0019] The fish were divided into a treatment group and a control group. There were 10 koi in the treatment group, with a body length of 20.5-22.0 cm and a diameter of 3-4 cm at the ulcer site. There were 10 koi in the control group, with a body length of 19.5-22.0 cm and a diameter of 3-4 cm at the ulcer site. The treatment group was treated with drugs, while the control group was not treated with drugs. Other daily management such as feeding and water change were the same. During the treatment period, the fish were fed once a day at 9 am, and the feeding amount was 0.5% of the fish body weight. The treatment water temperature was 23-25 ​​degrees Celsius.

[0020] Treatment steps include the following:

[0021] S1. Aerate the clean water formed by filtering tap water for 24 hours;

[0022] S2. Add povidone iodine solution, oxytetracycline, metronidazole and chlorogenic acid to the clean water after aeration in step S1 to prepare treatment water. The ratio of tap water to povidone iodine solution is 0.07 ml of 10% povidone iodine solution by mass volume ratio per 100 liters of water, the ratio of clean water to oxytetracycline tablets is 1 gram of oxytetracycline per 100 liters of clean water, the ratio of clean water to metronidazole tablets is 2 grams of metronidazole per 100 liters of clean water, and the ratio of clean water to chlorogenic acid is 0.15 grams of chlorogenic acid per 100 liters of clean water;

[0023] S3, adding the treatment water described in step S2 into the culture container, and oxygenating the whole process;

[0024] S4. Place the diseased fish in a breeding container for a medicinal bath, and replace the therapeutic water in the breeding container with reconfigured therapeutic water every 12 hours. Continue treatment for 15 days.

[0025] Treatment results:

[0026] The symptoms before and after treatment in the treatment group were as follows:

[0027] Symptoms of the treatment group before treatment: The skin tissue on the ulcer surface of the diseased fish disappeared, the muscles were exposed and rotten, and the rotten muscles were white and flocculent.

[0028] Symptoms of the treatment group after treatment: From the second day of treatment, black scab tissue began to form around the ulcer surface of 10 diseased fish, and the rotten muscles began to fall off. On the fifteenth day of treatment, the rotten muscles on the original ulcer surface basically disappeared, new epithelial tissue was formed, the ulcer surface healed, and no saprolegniasis occurred.

[0029] Symptoms of the control group before treatment: the skin tissue on the ulcer surface disappeared, the muscles were exposed and rotten, and the rotten muscles were white and flocculent.

[0030] Symptoms of the control group after treatment: the ulcer area of ​​10 diseased fish continued to expand, one fish died on the fifth, seventh and tenth day of treatment, and four diseased fish developed saprolegniasis.

[0031] Example 2

[0032] Breeding facilities: Two 122-liter glass fish tanks (0.6 meters long, 0.45 meters wide, and 0.45 meters high) are used as breeding containers, equipped with oxygen pumps for full-time oxygenation.

[0033] The fish were divided into a treatment group and a control group. The treatment group had 10 goldfish, with a body length of 6.5-8.0 cm and an ulcer diameter of 0.9-1.5 cm. The control group had 10 goldfish, with a body length of 7.5-8.5 cm and an ulcer diameter of 0.9-1.5 cm. The treatment group was treated with drugs, while the control group was not treated with drugs. Other daily management such as feeding and water change were the same. During the treatment period, the fish were fed once at 9 am every day, and the feeding amount was 0.5% of the fish weight. The treatment water temperature was 22-23 degrees Celsius.

[0034] Treatment steps include the following:

[0035] S1. Aerate the clean water formed by filtering tap water for 24 hours;

[0036] S2. Add povidone-iodine solution, oxytetracycline, metronidazole and chlorogenic acid to the clean water after aeration in step S1 to prepare treatment water. The ratio of tap water to povidone-iodine solution is 0.07 ml of 10% povidone-iodine solution by mass volume ratio per 100 liters of water, the ratio of clean water to oxytetracycline is 1 gram of oxytetracycline per 100 liters of clean water, the ratio of clean water to metronidazole is 2 grams of metronidazole per 100 liters of clean water, and the ratio of clean water to chlorogenic acid is 0.15 grams of chlorogenic acid per 100 liters of clean water;

[0037] S3, adding the treatment water described in step S2 into the culture container, and oxygenating the whole process;

[0038] S4. Place the diseased fish in a breeding container for a medicinal bath, and replace the treatment water in the breeding container with freshly prepared treatment water every 6 hours. Continue treatment for 16 days.

[0039] Treatment results:

[0040] The symptoms before and after treatment in the treatment group were as follows:

[0041] Symptoms of the treatment group before treatment: The skin tissue on the ulcer surface of the diseased fish disappeared, the muscles were exposed and rotten, and the rotten muscles were white and flocculent.

[0042] Symptoms of the treatment group after treatment: From the second day of treatment, black scab tissue began to form around the ulcer surface of 10 diseased fish, and the rotten muscles began to fall off. On the sixteenth day of treatment, the rotten muscles on the original ulcer surface completely disappeared, new epithelial tissue was formed, the ulcer surface healed, and no saprolegniasis occurred.

[0043] Symptoms of the control group before treatment: the skin tissue on the ulcer surface disappeared, the muscles were exposed and rotten, and the rotten muscles were white and flocculent.

[0044] Symptoms of the control group after treatment: the ulcer area of ​​10 diseased fish continued to expand, and diseased fish died on the second, fifth, seventh and tenth days of treatment, a total of 6 deaths, and 4 diseased fish developed saprolegniasis.

[0045] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A medicine for treating ulcers on the body surface of freshwater ornamental fish caused by trauma, characterized in that: Every 100 liters of water contains the following ingredients: 0.07-0.09 ml of 10% mass-to-volume concentration of povidone-iodine solution, 0.75-1.5 g of oxytetracycline, 1.5-3.0 g of metronidazole, and 0.1-0.2 g of chlorogenic acid.

2. The method for using the drug for treating freshwater ornamental fish surface ulcers caused by trauma as claimed in claim 1, characterized in that: The following steps are involved: (1) Take clean water after 24 hours of aeration, adjust the pH value and temperature to the suitable range for diseased ornamental fish, and continue aeration to maintain the dissolved oxygen concentration of the water at 5-8 mg / L; (2) Add povidone iodine solution, oxytetracycline, metronidazole, and chlorogenic acid to the above clean water in proportion to prepare a treatment solution. (3) Keep the sick fish in treatment water and slowly replace the reconfigured treatment water every 6-12 hours until the sick fish recovers.