Traditional Chinese medicine composition for treating ulcerative colitis

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating ulcerative colitis, which is characterized in that the traditional Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 5-15 parts of ginseng, 8-25 parts of cassia twig, 5-15 parts of nutmeg, 8-25 parts of poria cocos, 8-25 parts of roasted rhizoma atractylodis macrocephalae, 5-15 parts of rhizoma zingiberis, 10-30 parts of roasted semen coicis, 1-5 parts of indigo naturalis and 2-6 parts of coptis chinensis. According to the traditional Chinese medicine composition, ginseng, rhizoma atractylodis macrocephalae and poria cocos are used as monarch drugs together, and rhizoma atractylodis macrocephalae and poria cocos have the effects of replenishing qi to invigorate the spleen and eliminating dampness and excreting dampness together; semen coicis and rhizoma zingiberis are used as ministerial drugs and co-help the monarch drugs to resolve dampness and stop diarrhea; the traditional Chinese medicine composition has the functions of invigorating the spleen, replenishing qi, warming the kidney, stopping diarrhea, excreting dampness and removing toxicity, is mainly used for treating ulcerative colitis and irritable bowel syndrome (diarrhea type) clinically, can also be used for diagnosing'diarrhea 'and'stomachache' in traditional Chinese medicine, and can be used for treating clinical symptoms such as stomachache, diarrhea, mucus stool, even mucus purulent bloody stool, incomplete defecation, urgent defecation and abdominal distension.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and more particularly to a traditional Chinese medicine composition for treating ulcerative colitis. Background Art

[0002] Ulcerative colitis (UC) is a chronic nonspecific intestinal inflammatory disease, often manifested by recurrent chronic diarrhea, bloody stools with mucus, pus, and abdominal pain. As the onset of ulcerative colitis is related to abnormal immune mechanisms, its course is prolonged and prone to multiple complications. It is one of the modern intractable diseases recognized by the World Health Organization.

[0003] In clinical practice, we often encounter patients who do not respond well to commonly used therapeutic drugs such as mesalazine, hormones, immunosuppressants and biological agents, and suffer from the pain brought by the disease.

[0004] In traditional Chinese medicine, ulcerative colitis is not a simple intestinal problem, but reflects the imbalance of the body's internal organs, stagnation of qi and blood, and disordered movement of body fluids. Tracing back to the source, most of the time, it is due to the mutual influence of factors such as dampness taking advantage of the opportunity, uncontrolled daily diet, and emotional ups and downs, which damage the spleen and stomach, the transportation and transformation center, and malfunction of the large intestine's conduction function. Over time, phlegm, dampness, and blood stasis accumulate in the intestinal mucosa, causing damage, and then inducing ulcers and erosions. Traditional Chinese medicine treats ulcerative colitis, pays attention to overall conditioning, syndrome differentiation and treatment, starting from the root of the internal organs, and accurately using drugs to achieve the purpose of treating both the symptoms and the root causes.

[0005] To this end, the present invention provides a Chinese medicine composition for treating ulcerative colitis. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine composition for treating ulcerative colitis.

[0007] In order to achieve the above-mentioned purpose, the present invention provides a traditional Chinese medicine composition for treating ulcerative colitis, which is prepared by extracting the following raw medicinal materials in parts by weight: 5-15 parts of ginseng, 8-25 parts of cinnamon twigs, 5-15 parts of nutmegs, 8-25 parts of poria cocos, 8-25 parts of stir-fried atractylodes macrocephala, 5-15 parts of dried ginger, 10-30 parts of stir-fried coix seeds, 1-5 parts of indigo naturalis, and 2-6 parts of coptis chinensis.

[0008] Preferably, the Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 8-12 parts of ginseng, 12-20 parts of cinnamon twigs, 8-12 parts of nutmeg, 12-20 parts of Poria cocos, 12-20 parts of stir-fried Atractylodes macrocephala, 8-12 parts of dried ginger, 15-25 parts of stir-fried Coix seeds, 2-4 parts of Indigo naturalis, and 3-5 parts of Coptis chinensis.

[0009] Preferably, the Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 10 parts of ginseng, 15 parts of cinnamon twig, 10 parts of nutmeg, 15 parts of Poria, 15 parts of stir-fried Atractylodes macrocephala, 10 parts of dried ginger, 20 parts of stir-fried Coix seeds, 3 parts of Indigo naturalis, and 4 parts of Coptis chinensis.

[0010] Preferably, the extraction and preparation method is: weigh ginseng, cinnamon twig, nutmeg, poria, stir-fried atractylodes, dried ginger, stir-fried coix seed, indigo and coptis chinensis, a total of 9 raw medicinal materials, add water and boil twice, filter, combine the filtrates from the two decoctions, concentrate the filtrate to a relative density of 1.05 to 1.10, and add excipients to prepare a pharmaceutical preparation.

[0011] Preferably, the decoction is performed twice by first adding 12 to 15 times the total weight of the raw medicinal materials in water, soaking for 0.5 to 1 hour, and then decocting for 1 to 1.5 hours; and secondly adding 8 to 10 times the total weight of the raw medicinal materials in water, and decocting for 45 to 60 minutes.

[0012] Preferably, the excipient is a medically acceptable excipient.

[0013] Preferably, the pharmaceutical preparation is one of a decoction, a pill, a granule, a capsule, a tablet, a powder, an ointment, an oral liquid, or a powder.

[0014] The present invention also provides an application of the traditional Chinese medicine composition in preparing a medicine for treating ulcerative colitis.

[0015] The present invention also provides an application of the Chinese medicine composition in preparing a medicine for treating irritable bowel syndrome.

[0016] Preferably, the irritable bowel syndrome is diarrhea-predominant irritable bowel syndrome.

[0017] It should be noted that the pharmacological effects of the raw medicinal materials in the Chinese medicine composition of the present invention are as follows:

[0018] Ginseng: The dried root and rhizome of Panax ginseng CAMey., a plant of the Araliaceae family. Nature and flavor and meridians: sweet, slightly bitter, slightly warm. It enters the spleen, lung, heart, and kidney meridians. Functions and indications: Greatly replenishes vital energy, restores the pulse and consolidates the body, replenishes the spleen and lungs, promotes the production of body fluids and nourishes blood, and calms the mind and improves intelligence. It is used for weakness and impotence, cold limbs and weak pulse, spleen deficiency and poor appetite, lung deficiency and wheezing and coughing, thirst due to loss of body fluids, internal heat and thirst, qi and blood deficiency, long-term illness and weakness, palpitations and insomnia, impotence and cold uterus.

[0019] Cinnamon twig: Dried young twigs of Cinnamomum cassiaPresl, a plant of Lauraceae. Nature and flavor and meridians: pungent, sweet, warm. Enters the heart, lung, and bladder meridians. Functions and indications: induces sweating and relieves muscle pain, warms and dredges the meridians, assists yang and transforms qi, and balances and descends qi. Used for colds, cold pain in the abdomen, amenorrhea due to cold blood, joint pain, phlegm and fluid retention, edema, palpitations, and running pig.

[0020] Nutmeg: Dried kernel of Myristica fragrans Houtt., a plant of the Myristicaceae family. Nature and flavor and meridians: pungent, warm. Enters the spleen, stomach, and large intestine meridians. Functions and indications: warms the middle and promotes the flow of qi, astringes the intestines and stops diarrhea. Used for spleen and stomach deficiency and cold, chronic diarrhea, abdominal distension and pain, loss of appetite and vomiting.

[0021] Poria: The dried sclerotium of the fungus Poria cocos (Schw.) Wolf of the Polyporaceae family. Nature and flavor and meridians: sweet, light, neutral. It enters the heart, lung, spleen, and kidney meridians. Functions and indications: diuresis and dampness, spleen strengthening, and heart tranquilization. It is used for edema, oliguria, phlegm and fluid, dizziness and palpitations, spleen deficiency, poor appetite, loose stools and diarrhea, restlessness, palpitations, and insomnia.

[0022] Atractylodes: The dried rhizome of Atractylodes macrocephala Koidz. of the Asteraceae family. Stir-fried Atractylodes is prepared by sprinkling honey-roasted bran into a hot pan, adding Atractylodes slices when smoke appears, frying until yellow-brown and emitting a burnt aroma, taking it out, and sieving out the honey-roasted bran. Nature and flavor and meridians: sweet and bitter, sweet, warm. It enters the spleen and stomach meridians. Functions and indications: Strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating, and calming the fetus. It is used for spleen deficiency, poor appetite, abdominal distension and diarrhea, phlegm and fluid, dizziness and palpitations, edema, spontaneous sweating, and restless fetuses.

[0023] Dried ginger: dried rhizome of ginger plant Zingiber officinale Rosc. of the ginger family. Nature and flavor and meridians: pungent, hot. Enters the spleen, stomach, kidney, heart, and lung meridians. Functions and indications: warms the middle and dispels cold, restores yang and unclogs the meridians, warms the lungs and transforms fluid. Used for cold pain in the abdomen, vomiting and diarrhea, cold limbs and weak pulse, asthma and cough due to cold fluid.

[0024] Coix seeds: The dried mature seeds of Coix lacryma-jobi var.mayuen, a plant of the Gramineae family. Stir-fried coix seeds: Take clean coix seeds and stir-fry them according to the bran stir-fry method (General Rule 0213) until they turn slightly yellow. Nature and flavor and meridians: sweet, light, and cool. It enters the spleen, stomach, and lung meridians. Functions and indications: It can promote diuresis and eliminate dampness, strengthen the spleen and stop diarrhea, remove numbness, discharge pus, and detoxify and disperse stagnation. It is used for edema, beriberi, urination difficulties, diarrhea due to spleen deficiency, dampness and numbness, lung abscess, intestinal abscess, warts, and cancer. The cold and cool nature of stir-fried coix seeds is mild, and it is good at strengthening the spleen and stopping diarrhea. It can be used for diarrhea due to spleen deficiency and poor appetite and abdominal distension.

[0025] Coptis chinensis: the dried rhizome of Coptis chinensis Franch., Coptisdeltoidea CYChenget Hsiao or Coptis teetaWall. of the Ranunculaceae family. Nature and flavor and meridians: bitter, cold. It enters the heart, spleen, stomach, liver, gallbladder and large intestine meridians. Functions and indications: clearing away heat and dampness, purging fire and detoxifying. It is used for damp-heat fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactivity of heart fire, restlessness and insomnia, palpitations, vomiting and bleeding due to blood heat, red eyes, toothache, thirst, carbuncle, furuncle; external treatment of eczema, wet sores and pus in the ear canal.

[0026] Indigo: dried powder, agglomerate or granules obtained by processing leaves or stems of Baphicacanthus cusia (Nees) Bremek. of the Acanthaceae family, Polygonum tinctorium Ait. of the Polygonaceae family or Isatis indigotica Fort. of the Cruciferae family. Nature and flavor and meridians: salty, cold. Enters the liver meridian. Functions and indications: clearing away heat and detoxifying, cooling blood and eliminating spots, purging fire and calming convulsions. Used for spots caused by warm toxins, vomiting and bleeding due to blood heat, chest pain and coughing with blood, mouth sores, mumps, throat paralysis, and epilepsy in children.

[0027] It should also be noted that the Chinese medicine composition provided by the present invention is modified from Shenling Baizhu powder, the original recipe of which comes from Taiping Huimin Hejijufang, and is composed of ginseng, Atractylodes macrocephala (fried), Chinese yam, white lentil (fried), lotus seed, coix seed (fried), Amomum villosum, Platycodon grandiflorum and licorice, and has the functions of dispelling dampness and stopping diarrhea, strengthening the spleen and replenishing qi, and is commonly used in the treatment of diarrhea caused by spleen and stomach deficiency in clinical practice. This modified recipe not only has this function, but also has the effect of clearing away heat and detoxifying.

[0028] In the Chinese medicine composition provided by the present invention, ginseng is sweet and warm, enters the spleen and lung meridians, nourishes the spleen and lung qi, nourishes blood and produces body fluid. Atractylodes macrocephala is sweet, bitter and warm. Enters the spleen and stomach meridians, and has the functions of benefiting qi and strengthening the spleen, drying dampness and promoting diuresis. "National Medicine Interpretation" says: "Atractylodes macrocephala is neutral in nature and flavor, dry but not strong, and has a wide range of uses and significant efficacy, so it is necessary to treat dampness"; Poria cocos is sweet, light and flat. Enters the heart, spleen and kidney meridians, and has the functions of promoting diuresis and eliminating dampness, strengthening the spleen and calming the heart. Both have the functions of benefiting qi and strengthening the spleen, and drying dampness and eliminating dampness. These three are used together as the main medicine. Coix seed is sweet, light and cool, enters the spleen, stomach and lung meridians, strengthens the spleen and eliminates dampness, and helps the main medicine to benefit qi and strengthen the spleen, eliminate dampness and stop diarrhea, and are all minister medicines. Dry ginger is pungent and warm, enters the spleen and stomach meridians, warms the middle and stops diarrhea; the two help the main medicine to eliminate dampness and stop diarrhea, and are minister medicines. Coptis chinensis is bitter and cold, and enters the heart, spleen, stomach, gallbladder, and large intestine meridians. It has the effects of clearing away heat and dampness, purging fire and detoxifying. The Compendium of Materia Medica calls Coptis chinensis "the key medicine for treating eyes and dysentery" and the Compendium of Materia Medica states: "Coptis chinensis is the magic medicine for alcoholism and the magic herb for stagnation". Nutmeg is bitter, pungent, and warm, and enters the kidney and spleen meridians. It has the effects of tonifying the kidney and strengthening yang, consolidating essence and reducing urine, absorbing qi and relieving asthma, and warming the spleen and stopping diarrhea. The whole prescription is used for both tonifying and purging, and treats both deficiency and excess; it is mainly used to tonify qi and penetrate dampness, and is combined with products that raise yang, warm the middle and stop diarrhea, and lower the middle and lift the middle. Looking at the Chinese medicine composition provided by the present invention, the function can tonify the middle qi, penetrate dampness and turbidity, and promote qi stagnation, so as to achieve spleen qi health, remove dampness and toxins, and treat diarrhea.

[0029] Chronic diarrhea caused by different diseases is caused by spleen and stomach weakness (spleen yang deficiency, spleen qi deficiency), which runs through the beginning and end of the disease. Its essence is spleen qi deficiency, spleen yang deficiency and spleen and kidney yang deficiency, which is still yang deficiency in the final analysis. Wetness is a yin evil, and it is easy to trap spleen yang, so "Medical Ancestral Must-Read" has the saying "no dampness, no diarrhea". Therefore, the method of warming yang and strengthening the spleen should be the first essential for treating diarrhea. The key to the pathogenesis of late stage and recurrence is spleen and kidney deficiency, which is not only the basic pathological characteristics of the disease remission period, but also the susceptible constitution factor of the disease attack period. Therefore, whether it is the lesion repair treatment in the disease remission period or the anti-recurrence treatment of disease healing, warming the spleen and kidney should be placed in an important position. The Chinese medicine composition provided by the invention has the functions of strengthening the spleen and replenishing qi, warming the kidney and stopping diarrhea, and penetrating dampness and removing toxins, and can be used to treat ulcerative colitis and irritable bowel syndrome (diarrhea type), and has a significant effect.

[0030] The present invention has the following beneficial effects:

[0031] 1. The Chinese medicine composition provided by the present invention uses ginseng, Atractylodes macrocephala and Poria cocos as the main medicine, wherein Atractylodes macrocephala and Poria cocos both have the functions of invigorating qi and strengthening spleen and drying dampness and penetrating dampness. Coix seeds and dried ginger are used as assistant medicines, and the two together help the main medicine to eliminate dampness and stop diarrhea; it has the functions of invigorating spleen and invigorating qi, warming kidney and stopping diarrhea, penetrating dampness and removing toxins, and is clinically used to treat ulcerative colitis and irritable bowel syndrome (diarrhea type), and can also be used for the diagnosis of "diarrhea" and "abdominal pain" in traditional Chinese medicine, as well as the treatment of clinical symptoms of abdominal pain, diarrhea, mucus stool, even mucus pus and blood stool, feeling of incomplete defecation, urgency of defecation, abdominal distension and the like.

[0032] 2. Compared with Shenling Baizhu Powder, the Chinese medicine composition provided by the present invention not only has the effect of strengthening the spleen and removing dampness, but also has the effect of clearing away heat and detoxifying; the Chinese medicine composition of the present invention can achieve the purpose of treating both the symptoms and the root causes, relieve abdominal pain, diarrhea, mucous stools, even mucous, pus and bloody stools, a feeling of incomplete defecation, a feeling of urgency to defecate, abdominal distension and other symptoms, and at the same time can adjust the patient's physique and achieve microscopic histological healing of the intestinal mucosa, thereby improving the patient's quality of life and reducing the patient's medical expenses. DETAILED DESCRIPTION

[0033] In order to enable those skilled in the art to better understand the solution of the present invention, the technical solution of the present invention will be further described in detail below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without creative work should fall within the scope of protection of the present invention.

[0034] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present invention can be combined with each other. The present invention will be described in detail below in conjunction with the embodiments.

[0035] Embodiment 1:

[0036] A preparation method for a traditional Chinese medicine composition for treating ulcerative colitis. The traditional Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 10 parts of ginseng, 15 parts of cassia twig, 10 parts of nutmeg, 15 parts of poria, 15 parts of stir-fried atractylodes, 10 parts of dried ginger, 20 parts of stir-fried coix seeds, 3 parts of indigo, and 4 parts of coptis; wherein 1 part by weight = 1 g.

[0037] Weigh ginseng, cinnamon twig, nutmeg, poria, stir-fried atractylodes, dried ginger, stir-fried coix seed, indigo and coptis root, a total of 9 raw materials, add water and boil twice, add 1500ml of water for the first time, soak for 0.5 hours, boil for 1.5 hours, add 850ml of water for the second time, boil for 45 minutes. Filter, combine the filtrates of the two decoctions, concentrate the filtrate to a relative density of 1.05, and prepare a decoction.

[0038] Embodiment 2:

[0039] A preparation method for a traditional Chinese medicine composition for treating ulcerative colitis. The traditional Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 8 parts of ginseng, 12 parts of cassia twig, 8 parts of nutmeg, 12 parts of poria, 12 parts of stir-fried atractylodes, 8 parts of dried ginger, 15 parts of stir-fried coix seeds, 2 parts of indigo, and 3 parts of coptis; wherein 1 part by weight = 1 g.

[0040] Weigh the above 9 raw medicinal materials by weight, add water and boil twice, add 1500ml of water for the first time, soak for 1 hour, boil for 1 hour, add 1000ml of water for the second time, boil for 30min. Filter, combine the filtrates of the two decoctions, concentrate the filtrate to a relative density of 1.08, and prepare a decoction.

[0041] Embodiment three:

[0042] A preparation method for a traditional Chinese medicine composition for treating ulcerative colitis. The traditional Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 12 parts of ginseng, 20 parts of cassia twig, 12 parts of nutmeg, 20 parts of poria, 20 parts of stir-fried atractylodes, 12 parts of dried ginger, 25 parts of stir-fried coix seeds, 4 parts of indigo, and 5 parts of coptis; wherein 1 part by weight = 1 g.

[0043] The above 9 raw medicinal materials were weighed by weight, and decocted twice with water. For the first time, 1500 ml of water was added, and after soaking for 45 minutes, decocted for 1.5 hours. For the second time, 1100 ml of water was added and decocted for 30 minutes. Filter, combine the filtrates of the two decoctions, and concentrate the filtrate to a relative density of 1.10 to prepare a decoction.

[0044] Embodiment 4:

[0045] A preparation method for a traditional Chinese medicine composition for treating ulcerative colitis. The traditional Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 5 parts of ginseng, 8 parts of cassia twig, 5 parts of nutmeg, 8 parts of poria, 8 parts of stir-fried atractylodes, 5 parts of dried ginger, 10 parts of stir-fried coix seeds, 1 part of indigo, and 2 parts of coptis; wherein 1 part by weight = 1 g.

[0046] Weigh the above 9 raw medicinal materials by weight, add water and boil twice, add 800 ml of water for the first time, soak for 1 hour, boil for 1 hour, add 500 ml of water for the second time, boil for 30 minutes. Filter, combine the filtrates of the two decoctions, concentrate the filtrate to a relative density of 1.05, and prepare a decoction.

[0047] Embodiment five:

[0048] A preparation method for a traditional Chinese medicine composition for treating ulcerative colitis. The traditional Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 15 parts of ginseng, 25 parts of cassia twig, 15 parts of nutmeg, 25 parts of poria, 25 parts of stir-fried atractylodes, 15 parts of dried ginger, 30 parts of stir-fried coix seeds, 5 parts of indigo, and 6 parts of coptis; wherein 1 part by weight = 1 g.

[0049] Weigh the above 9 raw medicinal materials by weight, add water and boil twice, add 2000ml of water for the first time, soak for 1 hour, boil for 1.5 hours, add 1500ml of water for the second time, boil for 45 minutes. Filter, combine the filtrates of the two decoctions, concentrate the filtrate to a relative density of 1.10, and prepare a decoction.

[0050] The instruments and methods involved in Examples 1-5 are commonly used in the field of traditional Chinese medicine preparations.

[0051] Clinical trial cases:

[0052] In order to prove that the decoction prepared by the Chinese medicine composition of the present invention has a positive effect on the treatment of ulcerative colitis and irritable bowel syndrome (diarrhea type), the inventor conducted a clinical trial on patients using the decoction prepared in Example 1, and now selects part of the clinical trial report as follows:

[0053] 1. Patient: Fei Moumou, gender: male, age: 53 years old.

[0054] Chief complaint: diarrhea, mucus, pus and blood in stool for 3 years, aggravated for 3 months.

[0055] Current medical history: The patient had diarrhea without obvious cause 3 years ago, and the frequency of bowel movements increased, with 3-4 stools / day, accompanied by mucus, pus and blood. Colonoscopy showed: ulcerative colitis, widespread ulcers in the colon mucosa. Oral mesalazine, dexamethasone, and Chinese medicine enema treatment were given, and the symptoms were slightly relieved. After that, the symptoms recurred, and they were aggravated every time due to unclean diet, fatigue or emotional frustration. After fatigue 3 months ago, the symptoms worsened, and oral mesalazine 1g, 3 times / day, did not alleviate. Now: diarrhea, increased frequency of bowel movements, 6-7 times / day, tenesmus, dull abdominal pain, abdominal distension, cold abdomen, bowel sounds, bad breath, easy salivation, and bad mood. Usually afraid of cold, fatigue, and edema of both lower limbs. No chest tightness, palpitations, etc. Poor appetite and poor rest at night. Weight loss of 7kg since onset.

[0056] Tongue and pulse: The tongue is dark, the tongue coating is white and greasy, there are teeth marks on the edges, and the pulse is deep, weak and powerless.

[0057] diagnosis:

[0058] TCM diagnosis: dysentery

[0059] TCM syndrome: spleen and kidney yang deficiency combined with large intestine dampness and toxicity syndrome

[0060] Western medicine diagnosis: ulcerative colitis (active stage, whole colon, chronic persistent type, severe)

[0061] Treatment: Oral administration of mesalazine sustained-release granules 500 mg 3 times / day, combined with the decoction prepared in Example 1 of the present invention and adjusted Chinese medicine treatment for 5 months.

[0062] After 5 months, the symptoms were significantly improved: 1 bowel movement per day, yellow and formed, no mucus, pus or blood in the stool, 2 loose stools after occasional bad mood or dietary stimulation. Abdominal pain basically disappeared, appetite was good, night rest was better than before, fatigue was significantly improved, and weight increased by 3kg.

[0063] 2. Patient: Shi Moumou, gender: male, age: 52 years old.

[0064] Chief complaint: Intermittent diarrhea for more than 1 year, worsening for 3 months.

[0065] Current medical history: The patient had diarrhea without obvious cause 1 year ago, and the frequency of bowel movements increased to 3-4 times / day, with loose stools, accompanied by mucus, pus and blood. The pain in the lower abdomen was obvious, and it was diagnosed as ulcerative colitis intermittently. Oral mesalazine, compound glutamine, drug enema and other treatments were given, and the symptoms recurred. The above symptoms worsened after fatigue 3 months ago. At present: 4-5 bowel movements / day, loose stools, accompanied by mucus, pus and blood, tenesmus, obvious pain in the middle and lower abdomen, abdominal distension, cold abdomen, obvious fear of cold, tasteless mouth, clear and long urine, frequent nocturia. Poor appetite and poor sleep. Occasionally dizzy, tired and weak, no panic or shortness of breath.

[0066] Tongue and pulse: Dark tongue, white tongue coating, teeth marks on the edges, deep and weak pulse.

[0067] diagnosis:

[0068] TCM diagnosis: dysentery

[0069] TCM syndrome: spleen and kidney yang deficiency combined with large intestine dampness and toxicity syndrome

[0070] Western medicine diagnosis: ulcerative colitis (active stage, whole colon, initial onset, moderate)

[0071] Treatment: Oral administration of mesalazine sustained-release granules 500 mg 3 times / day, combined with the decoction prepared in Example 1 of the present invention and adjusted Chinese medicine treatment for 3 months.

[0072] After 3 months, the symptoms were significantly improved: bowel movement once a day, yellow and formed, without mucus, pus or blood, occasional abdominal pain after spicy food, no urgency, abdominal distension basically disappeared, abdominal coldness was significantly relieved, appetite was good, night rest was better than before, urination was normal, dizziness and fatigue were significantly relieved.

[0073] 3. Patient: Wang Moumou, gender: male, age: 48 years old.

[0074] Chief complaint: Recurrent mucus, pus and blood in stool for 6 months, aggravated for 2 weeks.

[0075] Current medical history: 6 months ago, the patient had no obvious cause and had bowel movements 2-3 times a day, accompanied by mucus, pus and blood, and a feeling of anal prolapse. Colonoscopy showed that the nature of the sigmoid colon and rectal ulcers was to be determined. Complete pathology suggested: chronic inflammation of the mucosa with erosion. The symptoms were relieved after taking mesalazine and compound glutamine. 2 weeks ago, the patient had blood in the stool again, accompanied by mucus, pus and blood. Now: 3-4 bowel movements per day, accompanied by mucus, pus and blood, mixed with a little undigested food, abdominal discomfort before defecation, relief after defecation, accompanied by a feeling of anal prolapse, dry mouth, usually cold abdomen, frequent belching, chills, fatigue, difficulty urinating, and general sleep.

[0076] Tongue and pulse: The tongue is enlarged, the tongue coating is dark, and the pulse is deep, weak and powerless.

[0077] diagnosis:

[0078] TCM diagnosis: dysentery

[0079] TCM syndrome: spleen and kidney yang deficiency combined with large intestine dampness and toxicity syndrome

[0080] Western medicine diagnosis: ulcerative colitis (active stage, whole colon, initial onset, moderate)

[0081] Treatment: Oral administration of mesalazine sustained-release granules 500 mg twice a day, combined with the decoction prepared in Example 1 of the present invention and adjusted Chinese medicine treatment for 2 months.

[0082] After 2 months, the symptoms were significantly improved: defecation once a day, no mucus, pus or blood, occasional loose stools after catching a cold, no anal prolapse, no undigested food. Appetite was good, abdominal coldness was better than before, and belching was reduced.

[0083] 4. Patient: Dong Moumou, gender: male, age: 53 years old.

[0084] Chief complaint: Recurrent abdominal pain with mucus, pus and blood in the stool for more than 2 years, aggravated for 5 days.

[0085] Current medical history: The patient had no obvious cause 2 years ago, and had lower and middle abdominal pain, increased bowel movements, 5-6 times / day, with mucus, pus and blood. Colonoscopy, combined with pathological diagnosis of ulcerative colitis. Oral prednisone acetate tablets, mesalazine enteric-coated tablets 1g, 3 times / day, sulfasalazine suppositories, etc. were given. The condition recurred, and it was aggravated every time due to fatigue or careless diet. Mucus, pus and blood appeared again 5 days ago, accompanied by abdominal pain and fatigue. At present: lower abdominal pain, abdominal distension, 7-8 bowel movements / day, mucus, pus and blood in the stool, tenesmus. Abdominal pain before defecation, pain relief after defecation, abdominal distension, bowel sounds, fatigue, cold limbs, sore waist and knees, and heavy lower limbs. Tasteless mouth, very poor appetite, poor night rest, frequent nocturia, clear and long urine. No chest tightness, shortness of breath, usually prone to spontaneous sweating.

[0086] Tongue and pulse: The tongue is dark purple, the tongue coating is white and slippery, and the pulse is deep, weak and powerless.

[0087] diagnosis:

[0088] TCM diagnosis: dysentery

[0089] TCM syndrome: spleen and kidney yang deficiency combined with large intestine dampness and toxicity syndrome

[0090] Western medicine diagnosis: ulcerative colitis (active stage, whole colon, chronic persistent type, severe)

[0091] Treatment: Oral administration of mesalazine sustained-release granules 500 mg 3 times / day, combined with the decoction prepared in Example 1 of the present invention and adjusted Chinese medicine treatment for 6 months.

[0092] After 6 months, the symptoms were significantly improved: 1-2 times / day of bowel movement, soft stool, no mucus, pus or blood, tenesmus disappeared, abdominal pain, bloating and bowel sounds were significantly relieved. Fatigue, cold limbs, chills, soreness of waist and knees were significantly improved.

[0093] 5. Patient: Zhang XX, gender: female, age: 59 years old.

[0094] Chief complaint: intermittent diarrhea with mucus, pus and blood in the stool for more than 3 months.

[0095] Current medical history: The patient had an increased frequency of bowel movements after eating spicy food 3 months ago, 2-3 times / day, with watery stools, accompanied by mucus, pus and blood. Colonoscopy and pathological diagnosis of ulcerative colitis. Oral mesalazine sustained release and Chinese medicine enema were given, but no significant relief was seen. At present: diarrhea, watery stools, accompanied by mucus, pus and blood, 2-3 times / day, tenesmus, occasional subumbilical abdominal pain, obvious on the left side, abdominal distension, frequent flatulence, occasional nausea, no vomiting, dry mouth and bitter mouth, easy hiccups, no acid reflux and heartburn, cold limbs, poor appetite, fatigue, poor night rest, normal urination. Weight loss of about 4kg in the past 3 months.

[0096] Tongue and pulse: pale tongue, thin white coating, enlarged tongue with teeth marks on the edges, deep and weak pulse.

[0097] diagnosis:

[0098] TCM diagnosis: dysentery

[0099] TCM syndrome: spleen and kidney yang deficiency combined with large intestine dampness and toxicity syndrome

[0100] Western medicine diagnosis: ulcerative colitis (active stage, left colon, initial onset, mild)

[0101] Treatment: Oral administration of mesalazine sustained-release granules 500 mg twice a day, combined with the decoction prepared in Example 1 of the present invention and adjusted Chinese medicine treatment for 2 months.

[0102] After 2 months, the symptoms were significantly improved: 1 bowel movement / day, formed, no mucus, pus or blood, no abdominal pain, bloating, no feeling of heaviness in the anus, hiccups were significantly relieved, no acid reflux and heartburn, good appetite, good night sleep, normal urination. Weight increased by 2kg.

[0103] 6. Patient: Zhao Moumou, gender: male, age: 39 years old.

[0104] Chief complaint: intermittent diarrhea with mucus, pus and blood in the stool for more than 2 years, worsening for 1 month.

[0105] Current medical history: The patient had pain in the middle and lower abdomen without obvious cause 2 years ago, and the frequency of bowel movements increased, 4-5 times / day, with thin and unformed stools. Colonoscopy showed: the nature of colon and rectal ulcers is to be determined, and the pathology is complete, indicating chronic inflammation of the "ascending colon" mucosa with erosion, and moderate chronic active inflammation of small pieces of intestinal mucosa in the "rectum". Intermittent use of "salazine sustained-release granules, mesalazine suppositories, enema" and other treatments, with general efficacy and repeated symptoms. The above symptoms worsened after careless diet 1 month ago. At present: pain in the middle and lower abdomen, increased frequency of bowel movements, 4-5 times / day, accompanied by mucus, pus and blood in the stool; abdominal pain before defecation, pain reduced after defecation; abdominal distension, paroxysmal, fullness in the stomach; acid reflux and heartburn, occasional dry mouth and bitter mouth; no dizziness, headache, chest tightness, palpitations, shortness of breath; poor diet, normal night rest, normal urination.

[0106] Tongue and pulse: pale tongue, thin yellowish coating with teeth marks on the edges, deep and weak pulse.

[0107] diagnosis:

[0108] TCM diagnosis: dysentery

[0109] TCM syndrome: spleen and kidney yang deficiency combined with large intestine dampness and toxicity syndrome

[0110] Western medicine diagnosis: ulcerative colitis (active stage, left colon, chronic persistent type, moderate)

[0111] Treatment: Oral administration of 160 mg of Qilong capsules, 3 times / day, combined with the decoction prepared in Example 1 of the present invention for 5 months.

[0112] The symptoms were significantly improved during follow-up examination 5 months later: bowel movement once a day, yellow and formed, without mucus, pus or blood in the stool, occasional abdominal pain, no feeling of heaviness in the anus, no acid reflux or heartburn, no chest tightness, palpitations or shortness of breath, good appetite, good sleep at night, and normal urination.

[0113] 7. Patient: Li Moumou, gender: female, age: 51 years old.

[0114] Chief complaint: intermittent diarrhea with mucus, pus and blood in the stool for more than 3 years, worsening for 1 week.

[0115] Current medical history: The patient had increased bowel movements with mucus and a small amount of blood without obvious cause 3 years ago. Colonoscopy showed: the nature of the colon and rectal ulcers is to be determined, and the pathology is complete, indicating chronic inflammation of the "ascending colon" mucosa with erosion, and moderate chronic active inflammation of the small intestinal mucosa of the "rectum". Oral mesalazine and Chinese medicine (unknown details) are used for treatment, and it is easy to relapse after stopping the medication. Lower abdominal pain occurred after eating spicy food 1 week ago, and the number of bowel movements increased to 3-5 times / day. Now: The number of bowel movements increased, 3-5 times / day, the stool was not digested, accompanied by a feeling of incomplete bowel movements and a feeling of anal prolapse. Lower abdominal pain, abdominal distension, frequent flatulence, bad breath, cold limbs, sore waist and knees. Loss of appetite, can rest at night. Normal urination. Occasionally dry mouth, no bitter mouth, obvious fatigue. No chest tightness, palpitations, shortness of breath.

[0116] Tongue and pulse: dark tongue, thin yellow fur, deep, weak and powerless pulse.

[0117] diagnosis:

[0118] TCM diagnosis: dysentery

[0119] TCM syndrome: spleen and kidney yang deficiency combined with large intestine dampness and toxicity syndrome

[0120] Western medicine diagnosis: ulcerative colitis (active stage, whole colon, chronic persistent type, moderate)

[0121] Treatment: Oral administration of mesalazine sustained-release granules 500 mg 3 times / day, combined with the decoction prepared in Example 1 of the present invention and adjusted Chinese medicine treatment for 6 months.

[0122] The symptoms were significantly improved during follow-up examination 6 months later: bowel movements were once a day, basically formed, without mucus, pus or blood, abdominal pain and bloating had basically disappeared, there was no feeling of tenesmus, appetite improved, fatigue, soreness in the waist and knees were alleviated.

[0123] 8. Patient: Zhao Moumou, gender: female, age: 41 years old.

[0124] Chief complaint: intermittent abdominal pain, diarrhea, mucus, pus and blood in the stool for more than 6 months, worsening for 1 week.

[0125] Current medical history: The patient had abdominal pain and diarrhea 6 months ago due to careless eating, 2-3 times / day, in a thin and mushy state, accompanied by mucus, pus and blood, which was more obvious after eating greasy food. Colonoscopy showed: ulcerative colitis, extensive ulcers in the colon mucosa. After oral administration of "Guchang Zhixie Pills and Mesalazine", the symptoms were relieved, and then recurred, sometimes mild and sometimes severe. One week ago, the above symptoms recurred and worsened due to careless eating. At present: abdominal pain, diarrhea, 2-3 times / day, in a thin and mushy state, accompanied by mucus, pus and blood, poor defecation, feeling of incomplete defecation, dull pain around the umbilicus before defecation, slightly relieved after defecation, cold abdomen, bowel sounds, reduced appetite, fatigue, normal urination, and normal sleep. Usually dry mouth, bitter mouth, fatigue and weakness.

[0126] Tongue and pulse: dark tongue, thin yellow fur, deep and weak pulse.

[0127] diagnosis:

[0128] TCM diagnosis: dysentery

[0129] TCM syndrome: spleen and kidney yang deficiency combined with large intestine dampness and toxicity syndrome

[0130] Western medicine diagnosis: ulcerative colitis (active stage, whole colon, initial stage, mild)

[0131] Treatment: Oral administration of mesalazine sustained-release granules 500 mg 3 times / day, combined with the decoction prepared in Example 1 of the present invention and adjusted Chinese medicine treatment for 3 months.

[0132] After 3 months, the symptoms were significantly improved: abdominal pain disappeared, bowel movements were once a day, yellow and formed, without mucus, pus or blood, and the feeling of incomplete defecation and bowel sounds disappeared. The appetite was better than before, dry mouth disappeared, and the bitter taste in the mouth was reduced.

[0133] 9. Patient: Liu Moumou, gender: female, age: 58 years old.

[0134] Chief complaint: Recurrent mucus, pus and blood in stool for 3 years, worsening for 1 month.

[0135] Current medical history: The patient developed abdominal pain and diarrhea 3 years ago due to irregular diet, 2-3 times / day, accompanied by a small amount of mucus, pus and blood in the stool. Colonoscopy and pathological diagnosis were ulcerative colitis. Oral mesalazine tablets were given for treatment, and the symptoms were relieved. After that, abdominal pain, diarrhea, mucus, pus and blood in the stool were seen after eating spicy and greasy food. The condition was repeated and prolonged. The above symptoms worsened again one month ago. At present: abdominal pain, obvious on the left side, diarrhea, thin and mushy stool with mucus, pus and blood, conscious anus heavy during defecation, incomplete defecation, anus falling, defecation 4-5 times / day, relieved after defecation, abdominal distension, abdominal pain, fatigue, pale complexion, sore waist and knees, weakness in both lower limbs, poor appetite, clear and long urine. Weight loss of 6kg in the past year.

[0136] Tongue and pulse: Dark tongue, dark coating, deep, weak pulse.

[0137] diagnosis:

[0138] TCM diagnosis: dysentery

[0139] TCM syndrome: spleen and kidney yang deficiency combined with large intestine dampness and toxicity syndrome

[0140] Western medicine diagnosis: ulcerative colitis (active stage, left colon, chronic relapsing type, moderate)

[0141] Treatment: Oral administration of mesalazine sustained-release granules 500 mg 3 times / day, combined with the decoction prepared in Example 1 of the present invention for 6 months, and later the mesalazine sustained-release granules were adjusted to 500 mg 2 times / day.

[0142] After 6 months, the symptoms were significantly improved: 1-2 bowel movements per day, no mucus, pus or blood, no anal prolapse, good appetite, soreness of waist and knees, weakness of lower limbs, etc., and weight increased by 3kg.

[0143] 10. Patient: Liu XX, gender: male, age: 64 years old.

[0144] Chief complaint: intermittent abdominal pain and bloody stool for more than one month.

[0145] Current medical history: The patient had lower abdominal pain without obvious cause one month ago, and the frequency of bowel movements increased, about 3-4 times / day, unformed, with blood, no mucus, and the abdominal pain was relieved after defecation. Colonoscopy combined with pathology diagnosed ulcerative colitis. At present: the frequency of bowel movements increased, 4-5 times / day, thin, unformed, with bright red and mucus; abdominal pain before defecation, pain relieved after defecation; abdominal distension, paroxysmal, fullness in the stomach; acid reflux and heartburn, occasional dry mouth and bitter taste; no dizziness, headache, chest tightness, palpitations, shortness of breath; poor diet, normal night rest, normal urination.

[0146] Tongue and pulse: pale tongue, thin yellowish coating with teeth marks on the edges, deep and weak pulse.

[0147] diagnosis:

[0148] TCM diagnosis: dysentery

[0149] TCM syndrome: spleen and kidney yang deficiency combined with large intestine dampness and toxicity syndrome

[0150] Western medicine diagnosis: ulcerative colitis (active stage, whole colon, initial onset, moderate)

[0151] Treatment: Oral mesalazine sustained-release granules 500 mg 3 times a day, combined with outpatient warm water Bu Tu Qu Du Tang with modifications of traditional Chinese medicine treatment for 3 months.

[0152] The symptoms were significantly improved during follow-up examination 3 months later: bowel movement once a day, yellow and formed, without mucus, pus or blood in the stool, occasional abdominal pain, no feeling of heaviness in the anus, no acid reflux or heartburn, no chest tightness, palpitations or shortness of breath, good appetite, good sleep at night, and normal urination.

[0153] In summary, the Chinese medicine composition of the present invention has a significant effect in treating ulcerative colitis.

[0154] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. A Chinese medicine composition for treating ulcerative colitis, characterized in that: The Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 5-15 parts of ginseng, 8-25 parts of cassia twig, 5-15 parts of nutmeg, 8-25 parts of poria, 8-25 parts of stir-fried atractylodes, 5-15 parts of dried ginger, 10-30 parts of stir-fried coix seeds, 1-5 parts of indigo, and 2-6 parts of coptis.

2. A Chinese medicine composition for treating ulcerative colitis according to claim 1, characterized in that: The Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 8-12 parts of ginseng, 12-20 parts of cassia twig, 8-12 parts of nutmeg, 12-20 parts of poria, 12-20 parts of stir-fried atractylodes, 8-12 parts of dried ginger, 15-25 parts of stir-fried coix seeds, 2-4 parts of indigo, and 3-5 parts of coptis.

3. A Chinese medicine composition for treating ulcerative colitis according to claim 1, characterized in that: The Chinese medicine composition is prepared by extracting the following raw medicinal materials in parts by weight: 10 parts of ginseng, 15 parts of cassia twig, 10 parts of nutmeg, 15 parts of poria, 15 parts of stir-fried atractylodes, 10 parts of dried ginger, 20 parts of stir-fried coix seeds, 3 parts of indigo, and 4 parts of coptis.

4. The Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The extraction and preparation method comprises the following steps: weighing 9 raw medicinal materials, namely, ginseng, cinnamon twig, nutmeg, poria, stir-fried atractylodes, dried ginger, stir-fried coix seed, indigo and coptis root, by weight, boiling them twice with water, filtering, combining the filtrates from the two decoctions, concentrating the filtrates to a relative density of 1.05 to 1.10, and adding auxiliary materials to prepare a pharmaceutical preparation.

5. The Chinese medicine composition according to claim 4, characterized in that: Specifically, the decoction is performed twice by first adding 12 to 15 times the total weight of the raw medicinal materials in water, soaking for 0.5 to 1 hour, and then decocting for 1 to 1.5 hours; and secondly adding 8 to 10 times the total weight of the raw medicinal materials in water, and decocting for 45 to 60 minutes.

6. The Chinese medicine composition according to claim 4, characterized in that: The auxiliary materials are medically acceptable auxiliary materials.

7. The Chinese medicine composition according to claim 4, characterized in that: The pharmaceutical preparation is one of decoction, pill, granule, capsule, tablet, powder, paste, oral liquid, or powder.

8. Use of the Chinese medicine composition according to any one of claims 5 to 7 in the preparation of a medicament for treating ulcerative colitis.

9. Use of the Chinese medicine composition according to any one of claims 5 to 7 in the preparation of a medicament for treating irritable bowel syndrome.

10. The use according to claim 9, characterized in that: The irritable bowel syndrome is diarrhea-type irritable bowel syndrome.