Catheter pump with oxygen supply function

Abstract

The application is a catheter pump with oxygen supply function which can improve oxygen supply of body circulation, the proximal end of the motor is connected with the catheter, the distal end is coaxially connected with an impeller, the outer periphery cover of the impeller is provided with a blood outflow cage, the distal end of the blood outflow cage is fixed with the proximal end of a blood inflow cage through a sleeve, the distal end of the blood inflow cage is further connected with a pigtail tube, an oxygen supply unit is arranged on the blood outflow cage, the oxygen supply unit generates oxygen according to physiological signals collected by a sensing unit in the ascending aorta according to time and demand, and releases the oxygen into the blood in the ascending aorta. In the process of assisting the heart to pump blood, the catheter pump can simultaneously supplement oxygen into the blood by using the oxygen supply unit, and improve the hypoxia condition of the whole body tissue. The oxygen supply unit is integrated on the catheter pump, and the catheter pump is intervened through the blood vessel together with the oxygen supply unit, so that the operation is simple, the damage to the blood vessel is reduced, the risk of gas embolism is reduced, the oxygen is better distributed, the oxygen supply mode is more in line with the physiological state, and the recovery of the patient is facilitated.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and specifically to a catheter pump with oxygen supply function. Background Technology

[0002] A catheter pump can be introduced percutaneously into the heart and can be configured to assist or replace the natural heart pumping function by pumping blood through circulation or continuous pumping, providing hemodynamic support for cardiogenic shock and acute heart failure. A catheter pump typically includes a motor, with the proximal end connected to the catheter and the distal end connected to an impeller. The motor drives the impeller to rotate, thereby drawing blood from the ventricles into the cannula via a blood inflow cage, and then out through the blood outflow cage proximal to the cannula into the artery, establishing a left ventricle-ascending aorta drainage pathway.

[0003] For some patients with acute myocardial infarction complicated by cardiogenic shock, whose heart's pumping function is drastically weakened, systemic tissue hypoxia occurs. Current technology uses catheter pumps to directly pump blood from the ventricles to the ascending aorta, which can assist the heart's pumping function, but it cannot replenish oxygen to the body and cannot quickly improve systemic tissue hypoxia. Achieving this function is a major challenge that urgently needs to be solved in the industry. Summary of the Invention

[0004] The purpose of this invention is to provide a duct pump with oxygen supply function that can directly improve the oxygen supply in the body circulation.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows: a duct pump with oxygen supply function, including a motor, the proximal end of the motor is connected to the duct, and the distal end is coaxially connected to an impeller. A blood outflow cage is provided on the outer periphery of the impeller. The distal end of the blood outflow cage is fixed to the proximal end of the blood inflow cage through a sleeve. The distal end of the blood inflow cage is also connected to a pig tail tube. An oxygen supply unit is provided on the blood outflow cage. The oxygen supply unit generates oxygen in the ascending aorta on a timely and demand-based basis according to the physiological signals collected by the sensing unit and releases oxygen into the blood of the ascending aorta.

[0006] Furthermore, the oxygen supply unit includes a microfluidic chip and an enzyme membrane. Hydrogen peroxide solution enters the microchannel from the liquid delivery tube and separates into independent hydrogen peroxide molecules. These hydrogen peroxide molecules contact the enzyme membrane and undergo a chemical reaction to generate… and , and It escapes and enters the bloodstream of the ascending aorta.

[0007] Furthermore, the oxygen supply unit includes a microfluidic chip, with a first inlet pipe for delivering hydrogen peroxide and a second inlet pipe for delivering catalase connected to the first and second sample ports of the microfluidic chip, respectively. The hydrogen peroxide solution undergoes a chemical reaction within the mixing channel of the microfluidic chip to generate… and , and The substrate escapes from the substrate outlet of the microfluidic chip and enters the bloodstream of the ascending aorta.

[0008] Furthermore, the blood outflow cage is generally cylindrical, with a bleeding window at the proximal end. The microfluidic chip is wrapped around the distal end of the cylindrical tube, and the microfluidic chip is an arc-shaped structure that conforms to the shape of the outer wall of the cylindrical tube. The wall thickness of the cylindrical tube segment corresponding to the microfluidic chip is less than the wall thickness of the tube segments on both sides. The outer wall of the microfluidic chip is smoothly connected to the outer walls of the tube segments on both sides. The liquid guide tube is connected to the liquid inlet of the microfluidic chip, and a microreaction chamber is connected to the substrate outlet of the microfluidic chip. The enzyme membrane is placed in the microreaction chamber.

[0009] Furthermore, the microreaction chamber is tubular in shape, with one end connected to the substrate outlet of the microfluidic chip and the other end having an outlet. An enzyme membrane is disposed in the inner cavity of the tube near the outlet, and the enzyme membrane divides the inner cavity of the tube. Catalase is fixed on the membrane on the side near the outlet.

[0010] Furthermore, the enzyme membrane is placed on a plastic sheet, and the electrode passes through and is adhered to the plastic sheet. The enzyme membrane and the electrode constitute an enzyme-catalyzed current sensor. The enzyme-catalyzed current sensor collects current signals and feeds them back to the control host. The control host adjusts and controls the delivery volume of hydrogen peroxide liquid from the microfluidic chip in real time.

[0011] Furthermore, the blood outflow cage is also equipped with an optical fiber sensor, which includes a sensing head and an optical fiber. The sensing head is fixed on the pipe section of the blood outflow cage and is arranged axially offset from the oxygen supply unit.

[0012] Furthermore, the sensing head and the micro-reaction chamber of the oxygen supply unit are arranged along the axial direction of the blood outflow cage, and the sensing head is near the micro-reaction chamber. The outer periphery of the sensing head and the micro-reaction chamber is provided with a protective cover, and there is a gap between the protective cover and the blood outflow cage to accommodate the sensing head and the micro-reaction chamber.

[0013] Furthermore, the outer wall of the protective cover is constructed as an arc-shaped flow guide surface extending from the distal end to the proximal end. There is at least one through hole on the flow-facing surface of the arc-shaped flow guide surface for blood to enter and flush the sensing head. The through hole is opened in the area between the sensing head and the micro-reaction chamber. The through hole is arranged obliquely and the edge is chamfered. The proximal end of the protective cover has a notch for the optical fiber to pass through.

[0014] Furthermore, a plane is provided along the axial direction on the outer wall of the blood outflow cage, the sensing head and the micro-reaction chamber are fixed on this plane, and both ends of the protective cover are also fixed on this plane.

[0015] Furthermore, a groove is provided on the motor housing, through which the optical fiber and liquid guide tube pass and through the internal conduit at the tail of the motor. The groove is filled with epoxy resin, and the conduit is also equipped with a flushing tube, an electric cable, and a reinforcing steel cable.

[0016] In the above-described approach, the catheter pump assists the heart in pumping blood while simultaneously replenishing the blood with oxygen from the oxygen supply unit, thereby improving systemic tissue hypoxia. The oxygen supply unit is integrated into the catheter pump and is inserted into the blood vessel together, simplifying operation and minimizing damage to blood vessels. Furthermore, the oxygen supply unit provides in-situ and on-demand oxygenation within the blood vessel; that is, it produces only the amount of oxygen needed in the blood. This method reduces the risk of gas embolism, improves oxygen distribution, and better aligns with physiological oxygen supply patterns, thus promoting patient recovery. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall structure of the duct pump in Example 1;

[0018] Figure 2 for Figure 1 A schematic diagram of the structure after removing the duct and pig tail tube;

[0019] Figure 3 This is a schematic diagram of the blood outflow cage and oxygen supply unit in Example 1. Figure 1 ;

[0020] Figure 4 This is a schematic diagram of the blood outflow cage and oxygen supply unit in Example 1. Figure 2 ;

[0021] Figure 5 This is a schematic diagram of the blood outflow cage in Example 1;

[0022] Figure 6 This is a planar unfolded schematic diagram of the oxygen supply unit in Example 1;

[0023] Figure 7 for Figure 6 Enlarged diagram of the middle section;

[0024] Figure 8 This is a schematic diagram of the microfluidic chip in Example 1;

[0025] Figure 9 for Figure 1 Sectional view along line AA;

[0026] Figure 10 This is a planar unfolded schematic diagram of the oxygen supply unit in Example 2;

[0027] Figure 11 This is a schematic diagram showing the operating status of the duct pump. Detailed Implementation

[0028] To facilitate understanding, let's first define the orientation: "proximal" or "proximal" refers to the side closer to the operator / doctor, while "distal" or "distal" refers to the side farther from the operator / doctor, i.e., the side closer to the heart. Below, we'll combine these definitions... Figures 1-11 The invention will be discussed in further detail.

[0029] like Figure 1 , Figure 2 As shown, a duct pump with oxygen supply function includes a motor 10. The proximal end of the motor 10 is connected to a duct 20, and the distal end is coaxially connected to an impeller. A blood outflow cage 30 is provided around the outer periphery of the impeller. The distal end of the blood outflow cage 30 is fixed to the proximal end of a blood inflow cage 50 through a sleeve 40. The distal end of the blood inflow cage 50 is also connected to a pig tail tube 60. An oxygen supply unit 70 is provided on the blood outflow cage 30. The oxygen supply unit 70 generates oxygen in the ascending aorta on a timely and demanding basis according to the physiological signals collected by the sensing unit and releases the oxygen into the blood of the ascending aorta.

[0030] In the above scheme, the catheter pump is inserted into the ventricle via a blood vessel. At this time, the pigtail tube 60, the blood inflow cage 50, and part of the cannula 40 are located in the left ventricle. The cannula 40 crosses the aortic valve, while part of the cannula, the blood outflow cage 30, and the motor 10 are located in the ascending aorta. The motor 10 drives the impeller to rotate, thereby pumping the blood from the left ventricle into the aorta, and then participating in systemic circulation. While assisting the heart in pumping blood, the catheter pump can simultaneously replenish oxygen in the blood using the oxygen supply unit 70, thereby improving systemic tissue hypoxia. Here, the oxygen supply unit 70 is integrated into the catheter pump and inserted into the blood vessel together with the catheter pump, simplifying operation and reducing damage to blood vessels. Simultaneously, the oxygen supply unit 70 generates oxygen in the blood vessel on a timed and demand-based basis; that is, it generates the required amount of oxygen in situ within the blood vessel at the time of oxygen demand.

[0031] Compared to directly introducing oxygen into the blood vessels, in-situ oxygen generation has the following beneficial effects:

[0032] 1. Reduced risk of gas embolism: When oxygen is directly injected into blood vessels, air bubbles may form during blood circulation, leading to gas embolism, which can obstruct normal blood flow, causing local tissue ischemia and hypoxia, and even endangering life. In-situ oxygen generation, on the other hand, produces oxygen inside the blood vessels, rather than through direct gas perfusion, thus greatly reducing the risk of gas embolism.

[0033] 2. Better oxygen distribution: Directly introducing oxygen into blood vessels makes oxygen distribution difficult to control because gas in blood vessels mainly flows with the blood, which may lead to local oxygen concentrations that are too high or too low. Intravascular in-situ oxygen production, on the other hand, can generate oxygen closer to the location where the tissue needs it (in this case, the ascending aorta), allowing oxygen to be distributed more precisely to the surrounding tissues and improving oxygen utilization efficiency.

[0034] 3. More in line with physiological oxygen supply patterns: Under normal physiological conditions, oxygen is produced through gas exchange in the alveoli and then carried and transported to all tissues by hemoglobin in the blood. In-situ intravascular oxygen production can simulate this more continuous and stable oxygen supply mode, rather than the abrupt gas input of direct ventilation. It can generate and supply oxygen more rationally in the blood vessels according to the actual oxygen demand of local tissues, which is more in line with physiological needs.

[0035] Another key aspect of this invention is the direct supply of oxygen to the ascending aorta. This approach also offers the following advantages:

[0036] 1. Directly improves systemic oxygen supply: The ascending aorta is the starting point of systemic circulation. Supplementing oxygen from here allows oxygen-rich blood to quickly enter the arterial system throughout the body. This is like opening a "fast track" for systemic circulation, which can rapidly improve oxygen supply to all tissues.

[0037] 2. Reducing the relative proportion of myocardial oxygen consumption: Because the supplemented oxygen enters the systemic circulation, it can improve the overall oxygen supply to a certain extent, reducing the "demand pressure" on other organs from the oxygen carried by the heart's pumping. This allows the heart to reduce the work it needs to do to maintain the oxygen supply to other organs, thereby reducing myocardial oxygen consumption to some extent.

[0038] 3. Minimal impact on pulmonary circulation: This method primarily supports systemic circulation, with relatively little interference to the hemodynamics and gas exchange processes of the pulmonary circulation itself. Because it does not directly alter the blood flow and gas exchange patterns within the heart, parameters such as pulmonary circulation pressure and flow rate will not undergo drastic changes due to oxygen supplementation in the ascending aorta. Example 1

[0039] In order to achieve on-demand oxygen production, it is desirable that hydrogen peroxide and catalase undergo only trace chemical reactions at a time, generating trace amounts of oxygen. Ideally, the hydrogen peroxide solution should be generated molecule by molecule. To achieve this, the oxygen supply unit 70 includes a microfluidic chip 71 and an enzyme membrane 72. Hydrogen peroxide solution enters the microchannel from the liquid delivery tube 73 and separates into independent hydrogen peroxide molecules. These hydrogen peroxide molecules contact the enzyme membrane 72 and undergo a chemical reaction to generate… and , and It escapes and enters the bloodstream of the ascending aorta. Here, oxygen is produced through a chemical reaction between hydrogen peroxide and catalase; the product of this reaction is... and ,in It mixes into the blood in the ascending aorta, replenishing the blood with oxygen, and It is also needed by the human body, so it will not cause any harm to the human body.

[0040] Membranes are excellent carriers for enzyme immobilization. Compared to ordinary chemical reactions, catalase-catalyzed reactions have a faster rate and are more efficient in... During the catalytic process, the higher the concentration of catalase, the better. The faster the catalysis, the better. Therefore, we immobilize catalase on the membrane to ensure a high concentration of catalase. The microfluidic chip 71 is made of a flexible material such as polydimethylsiloxane (PDMS) and has microchannels on it. The size of the microchannels is at the micrometer or even nanometer level, enabling precise control of the reaction amount. The technology of separating hydrogen peroxide solution into microdroplets using the microfluidic chip 71 is well-known and will not be described in detail here. After passing through the microchannels, the hydrogen peroxide solution is separated into spaced microdroplets, or even separated hydrogen peroxide molecules. Then, when the hydrogen peroxide molecules pass through the enzyme membrane 72, they react rapidly with the enzyme to obtain... It provides oxygen to the blood.

[0041] To achieve the above objectives, we use a microfluidic chip 71 to control the amount of hydrogen peroxide. The microfluidic chip 71, through microchannels and other functional components, can achieve precise manipulation of the fluid. Due to the microchannel design, micro-volume delivery of fluid is achieved, thus achieving in-situ oxygen production. The enzyme membrane 72 has a high concentration of catalase. When hydrogen peroxide molecules come into contact with the enzyme membrane 72, a chemical reaction occurs instantly, achieving timely oxygen supply. Through computer programming control, the transmission, mixing, and separation of microdroplets within the channels can be precisely achieved, thereby realizing quantitative oxygen production.

[0042] Since the catheter pump is administered via vascular intervention, its operation is limited by the diameter of the blood vessel. Therefore, the oxygen supply unit 70 needs to be rationally arranged to meet the requirements of vascular intervention. (See [reference needed]). Figures 3-8The blood outflow cage 30 is generally cylindrical, with a bleeding window 31 at the proximal end. The microfluidic chip 71 is wrapped around the distal end of the cylindrical tube and is an arc-shaped structure that conforms to the shape of the outer wall of the cylindrical tube. The wall thickness of the cylindrical section corresponding to the microfluidic chip 71 is smaller than the wall thickness of the sections on both sides. The outer wall of the microfluidic chip 71 smoothly connects to the outer walls of the sections on both sides. The liquid guide tube 73 communicates with the liquid inlet of the microfluidic chip 81, and a microreaction chamber 74 is connected to the substrate outlet of the microfluidic chip 71. The enzyme membrane 72 is disposed in the microreaction chamber 74. The microfluidic chip 71 is made of a substrate with flexible properties, such as PMDS material, to adapt to the surface shape of the blood outflow cage 30. This reduces the outer diameter of the conduit pump and increases the contact area between the microfluidic chip 71 and the surface of the blood outflow cage 30, improving the reliability of the connection. The two can be fixed by adhesive. The wall thickness of the circular tube segment corresponding to the microfluidic chip 71 is less than the wall thickness of the tube segments on both sides. In other words, there is an annular groove on the tube wall for installing the microfluidic chip 71. The outer wall of the microfluidic chip 71 is smoothly connected to the outer wall of the tube segments on both sides. From the outside, the outer diameter is similar or equal, thereby reducing the damage to blood vessels caused by the catheter pump during intervention and withdrawal.

[0043] The microreaction chamber 74 is tubular in shape, i.e., a micro-channel reaction chamber. It is small in volume, with one end connected to the substrate outlet of the microfluidic chip 71, and the other end having an outlet 741. An enzyme membrane 72 is disposed within the tubular lumen near the outlet, and the membrane 72 divides the lumen. Catalase is immobilized on a membrane sheet near the outlet 741. In other words, hydrogen peroxide can only react chemically with the enzyme when it passes through the membrane sheet to the other side. The reaction product... and No longer needing to pass through a diaphragm, it can enter the bloodstream more quickly and bind to the oxygen-deficient hemoglobin in the blood vessels at that moment, thus achieving timely and on-demand oxygen supply. A one-way valve / diaphragm structure can also be installed at outlet 741, allowing only... and It can escape while preventing blood from entering the microreaction chamber 74. Alternatively, the enzyme membrane 72 can selectively allow hydrogen peroxide to pass through easily, while blood... and Materials that cannot be passed through.

[0044] Furthermore, the enzyme membrane 72 is placed on a plastic sheet (shown in the figure), and the electrode (not shown in the figure) passes through and is adhered to the plastic sheet. The enzyme membrane 72 and the electrode constitute an enzyme-catalyzed current sensor. The enzyme-catalyzed current sensor collects the current signal and feeds it back to the control host. The control host adjusts and controls the delivery rate of hydrogen peroxide solution to the microfluidic chip 71 in real time. At the same time, the enzyme-catalyzed current sensor can also detect the formation of chemical reactions. Concentration, real-time reaction The formation process. Hydrogen peroxide undergoes a dismutation reaction with catalase attached to the membrane:

[0045]

[0046] In this way, two The molecules successively encounter and collide with CAT at the active site, undergoing a disproportionation reaction to generate two molecules. A molecule and a molecular.

[0047] When the catheter pump is working, its operating status needs to be monitored in real time, including key parameters such as flow rate and pressure. Therefore, a fiber optic sensor 80 is also installed on the blood outflow cage 30. Through fiber optic transmission technology, the fiber optic sensor 80 feeds back the detected data to the control system in real time, allowing operators to understand the operating status of the catheter pump in a timely manner and make corresponding adjustments and optimizations. The fiber optic sensor 80 includes a sensing head 81 and an optical fiber 82. The sensing head 81 is fixed on the tube section of the blood outflow cage 30 and is axially offset from the oxygen supply unit 70 to avoid affecting the measurement accuracy of the sensing head 81.

[0048] During transvascular intervention, the tortuous path and / or calcified anatomical structures of the catheter pump may obstruct and damage the sensing head 81 and the micro-reaction chamber 74. Therefore, the sensing head 81 and the micro-reaction chamber 74 of the oxygen supply unit 70 are arranged along the axial direction of the blood outflow cage 30, and the sensing head 81 is on the proximal side of the micro-reaction chamber 74. In this way, the sensing head 81 can be arranged axially in the micro-reaction chamber 74. The outer periphery of the sensing head 81 and the micro-reaction chamber 74 is provided with a protective cover 83. There is a gap between the protective cover 83 and the blood outflow cage 30 to accommodate the sensing head 81 and the micro-reaction chamber 74. Using the same protective cover 83 can effectively protect the sensing head 81 and the micro-reaction chamber 74 from damage. Compared with the method of setting the protective cover 83 separately on the sensing head 81 and the micro-reaction chamber 74, it has the following advantages: (1) less damage to blood vessels during intervention and withdrawal; (2) the protective cover 83 has a large axial length and a large space between it and the blood outflow cage 30, which can reduce blood retention and thrombus formation; (3) the protective cover 30 causes less damage to blood; (4) the protective cover 83 only needs to be welded once, which is simple to operate.

[0049] Considering the ease of insertion into blood vessels and the low damage to blood vessels, the outer wall of the protective cover 83 is constructed as an arc-shaped flow guide surface 831 extending from the distal end to the proximal end. At least one through-hole 832 is located on the flow-facing surface of the arc-shaped flow guide surface 831 to allow blood to enter and flush the sensing head 81. The through-hole 832 is located in the area between the sensing head 81 and the micro-reaction chamber 74. The through-hole 832 is obliquely arranged and its edge is chamfered to reduce blood damage. A notch 833 for the optical fiber 82 to pass through is provided at the proximal end of the protective cover 83. This C-shaped protective cover 83 has no notch at the distal end, preventing blood from directly impacting the micro-reaction chamber 74 and avoiding obstruction of oxygen release. The protective cover 83 is open on both sides, allowing blood to flow out smoothly, preventing blood stagnation and thrombus formation, and also facilitating the generation of oxygen by the oxygen supply unit 70. and The release of oxygen allows it to bind with hemoglobin in a timely manner. To ensure the accuracy of signal acquisition by the sensing head 81, a through hole 832 is provided on the front side of the arc-shaped guide surface 831 in the area between the sensing head 81 and the micro-reaction chamber 74 (for the outer surface of the C-shaped protective cover 83, the highest point is the boundary, the distal part is the front side, and the proximal part is the drainage side). The through hole 832 is arranged obliquely, thereby guiding the blood flow to directly flush the proximal sensing head 81, while not flushing the distal micro-reaction chamber 74.

[0050] Since the outer circumferential surface of the blood outflow cage 30 is a smooth circular surface, a plane 32 is provided along its axial direction on the outer wall of the blood outflow cage 30. The sensing head 81 and the micro-reaction chamber 74 are fixed on this plane 32, and both ends of the protective cover 83 are also fixed on this plane 32. This plane 32 provides a reliable mounting position for the sensing head 81, the micro-reaction chamber 74, and the protective cover 83, ensuring the firmness of the connection and further improving the safety and reliability of the entire tubing pump. Example 2

[0051] like Figure 10 As shown, the oxygen supply unit 70 includes a microfluidic chip 71. A first inlet pipe for delivering hydrogen peroxide and a second inlet pipe for delivering catalase are respectively connected to the first sample port and the second sample port of the microfluidic chip 71. The hydrogen peroxide solution undergoes a chemical reaction within the mixing channel of the microfluidic chip 71 to generate... and , and The substrate escapes from the substrate outlet of the microfluidic chip 71 and enters the blood in the ascending aorta. In this embodiment, two inlet tubes are provided to deliver hydrogen peroxide and catalase respectively, so there is no need to set up enzyme membranes or other structures, and even the microreaction chamber 74 does not need to be set up separately, but is set on the microfluidic chip 71. We use the microfluidic chip 71 to control the amount of hydrogen peroxide and catalase. Through microchannels, reaction chambers and other functional components, the microfluidic chip 71 can achieve precise manipulation of fluids and accurately realize the transmission, mixing and separation of microdroplets in the channels, thereby achieving quantitative oxygen production. Compared with Embodiment 1, this embodiment can omit the enzyme membrane unit and the additional microreaction chamber structure, so as to reduce the volume. However, correspondingly, the internal design of the microfluidic chip is relatively complex, and two inlet tubes are required, and the design of the lead-out of the inlet tubes is also more complicated.

[0052] A groove is formed on the housing of the motor 10. The optical fiber 82 and the fluid guide tube 73 pass through the groove and enter the catheter 20 from the tail of the motor 10. The groove is filled with epoxy resin. The optical fiber 82 and the fluid guide tube 73 are held in place in the groove and fixed with epoxy resin, thus ensuring the flatness and smoothness of the surface of the motor 10 housing and further reducing damage to blood vessels or other tissues during intervention. It should be noted that the optical fiber 82 and the fluid guide tube 73 are respectively placed in different grooves, and finally converge into the catheter 20 through the groove at the tail of the motor 10. When the catheter 20 and the tail of the motor 10 are fixed together by a fixing ring, the position of the optical fiber 82 and the fluid guide tube 73 is also defined. Figure 8 As shown, the catheter 20 is also equipped with a flushing tube 21, a cable 22, and a reinforcing steel cable 23. The fiber optic cable 82 is used to conduct optical signals, the fluid guide tube 73 is used to deliver hydrogen peroxide solution, the flushing tube 21 is used to deliver flushing fluid to prevent blood from entering the motor 10 and forming a thrombus, the cable 22 is used to power the motor 10, and the reinforcing steel cable 23 is used to enhance the rigidity of the catheter 20, enabling it to drive the catheter pump to the designated position.

[0053] The design of the oxygen supply unit described above can also be applied to right ventricular catheter pumps, foldable blood pumps, and IABP devices to supplement oxygen to different locations in the human body.

[0054] Of course, those skilled in the art will recognize that the present invention is not limited to the details of the exemplary embodiments described above, but also includes the same or similar structures that can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0055] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A duct pump with oxygen supply function, comprising a motor (10), the proximal end of the motor (10) being connected to a duct (20), and the distal end being coaxially connected to an impeller, the outer periphery of the impeller being provided with a blood outflow cage (30), the distal end of the blood outflow cage (30) being fixed to the proximal end of a blood inflow cage (50) through a sleeve (40), and the distal end of the blood inflow cage (50) being further connected to a pig tail tube (60), characterized in that: The blood outflow cage (30) is equipped with an oxygen supply unit (70). The oxygen supply unit (70) generates oxygen in the ascending aorta on time and as needed according to the physiological signals collected by the sensor unit and releases oxygen into the blood of the ascending aorta. The oxygen supply unit (70) includes a microfluidic chip (71) and an enzyme membrane (72). Hydrogen peroxide solution enters the microchannel from the liquid guide tube (73) and is separated into independent hydrogen peroxide molecules. The hydrogen peroxide molecules come into contact with the enzyme membrane (72) and undergo a chemical reaction to generate H2O and O2. H2O and O2 escape and enter the blood of the ascending aorta. The blood outflow cage (30) is in the shape of a cylindrical tube. A bleeding window (31) is provided in the proximal section of the cylindrical tube. The microfluidic chip (71) is wrapped around the tube body of the distal section of the cylindrical tube. The microfluidic chip (71) is an arc-shaped structure that fits the shape of the outer wall of the cylindrical tube. The wall thickness of the cylindrical tube section corresponding to the microfluidic chip (71) is smaller than the wall thickness of the tube sections on both sides. The outer wall of the microfluidic chip (71) is smoothly connected to the outer wall of the tube sections on both sides. The liquid guide tube (73) is connected to the liquid inlet of the microfluidic chip (71). A micro-reaction chamber (74) is connected to the substrate outlet of the microfluidic chip (71). The enzyme membrane (72) is set in the micro-reaction chamber (74). The blood outflow cage (30) is also equipped with an optical fiber sensor (80), which includes a sensing head (81) and an optical fiber (82). The sensing head (81) is located near the micro-reaction chamber (74). The outer periphery of the sensing head (81) and the micro-reaction chamber (74) is covered with a protective cover (83). There is a gap between the protective cover (83) and the blood outflow cage (30) to accommodate the sensing head (81) and the micro-reaction chamber (74).

2. The duct pump with oxygen supply function according to claim 1, characterized in that: The microreaction chamber (74) is tubular in shape. One end of the tube is connected to the substrate outlet of the microfluidic chip (71), and the other end is provided with an outlet (741). An enzyme membrane (72) is placed in the inner cavity of the tube near the outlet, and the enzyme membrane (72) divides the inner cavity of the tube. Catalase is fixed on a membrane on the side near the outlet (741). The enzyme membrane (72) is placed on a plastic sheet. The electrode passes through and is bonded to the plastic sheet. The enzyme membrane (72) and the electrode constitute an enzyme-catalyzed current sensor. The enzyme-catalyzed current sensor collects the current signal and feeds it back to the control host. The control host adjusts and controls the delivery amount of hydrogen peroxide liquid of the microfluidic chip (71) in real time.

3. A duct pump with oxygen supply function according to claim 1, characterized in that: The sensing head (81) is fixed on the section of the blood outflow cage (30) and is axially offset from the oxygen supply unit (70).

4. A duct pump with oxygen supply function according to claim 3, characterized in that: The sensing head (81) and the micro-reaction chamber (74) of the oxygen supply unit (70) are arranged along the axis of the blood outflow cage (30).

5. A duct pump with oxygen supply function according to claim 4, characterized in that: The outer wall of the protective cover (83) is constructed as an arc-shaped flow guide surface (831) extending from the distal end to the proximal end. The flow-facing surface of the arc-shaped flow guide surface (831) has at least one through hole (832) for blood to enter and flush the sensing head (81). The through hole (832) is opened in the area between the sensing head (81) and the micro-reaction chamber (74). The through hole (832) is arranged obliquely and the edge is chamfered. The proximal end of the protective cover (83) has a notch (833) for the optical fiber line (82) to pass through.

6. A duct pump with oxygen supply function according to claim 3, characterized in that: A plane (32) is provided on the outer wall of the blood outflow cage (30) along its axial direction. The sensing head (81) and the micro-reaction chamber (74) are fixed on the plane (32), and the two ends of the protective cover (83) are also fixed on the plane (32).

7. A duct pump with oxygen supply function according to claim 1, characterized in that: The motor (10) housing has a groove, through which the optical fiber (82) and liquid guide tube (73) pass and pass through the internal conduit (20) at the tail of the motor (10). The groove is filled with epoxy resin, and the conduit (20) is also equipped with a flushing tube (21), a cable (22) and a reinforcing steel cable (23).

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