Traditional Chinese medicine composition for treating viral warts as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for treating viral warts as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 20 to 30 parts of herba portulacae, 15 to 25 parts of radix isatidis, 25 to 35 parts of herba equiseti hiemalis, 25 to 35 parts of raw rhizoma cyperi, 5 to 15 parts of radix arnebiae seu lithospermi, 5 to 15 parts of herba patriniae, 1 to 5 parts of flos carthami, 15 to 25 parts of mirabilite and 5 to 15 parts of fructus bruceae. The traditional Chinese medicine composition provided by the invention has a good curative effect on viral warts, especially on palmoplantar warts and perineal warts, has the advantages of small side effects and difficulty in relapse, and is an ideal medicine for treating the palmoplantar warts and the perineal warts.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating viral warts, and a preparation method and application thereof. Background Art

[0002] Human papillomavirus (HPV) is a DNA virus. More than 100 HPV subtypes have been discovered. HPV infection usually leads to the occurrence of skin or mucosal growths - warts. Trauma and maceration can promote the initial inoculation of the virus in the skin. Then, self-inoculation leads to the spread of the virus. The spread of the virus is related to local and systemic immune function. In immunosuppressed patients (especially HIV-infected and renal transplant patients), skin lesions are particularly prone to widespread and difficult to treat.

[0003] Warts can occur anywhere on the body and have various forms. The diagnosis is based on physical examination. Warts are usually self-limited and can be treated with invasive treatments, topical or injected drugs. Invasive treatments for warts mainly include excision, laser or electric current burning, and freezing. However, invasive treatments are prone to local wound formation, skin lesions are prone to recurrence, and have greater side effects on patients. In view of this, it is particularly important to seek an effective treatment with few side effects, suitable for different age groups, and able to reduce the recurrence of viral warts. Summary of the invention

[0004] The invention aims to reduce the side effects of wart treatment and reduce the treatment wound.

[0005] To achieve the above-mentioned purpose, the first aspect of the present invention provides a traditional Chinese medicine composition for treating viral warts, which comprises the following components in parts by mass: 20-30 parts of purslane, 15-25 parts of isatis root, 25-35 parts of equisetum, 25-35 parts of raw cyperus, 5-15 parts of lithospermum, 5-15 parts of patrinia, 1-5 parts of safflower, 15-25 parts of sodium sulfate, and 5-15 parts of brucea javanica.

[0006] Preferably, the Chinese medicine combination comprises the following components by mass: 30 parts of purslane, 20 parts of isatis root, 30 parts of horsetail, 30 parts of raw cyperus, 10 parts of lithospermum, 10 parts of patrinia, 3 parts of safflower, 20 parts of sodium sulfate, and 10 parts of brucea javanica.

[0007] In the Chinese medicine composition provided by the present invention, Brucea brucea detoxifies and disperses stagnation, Purslane and Radix Isatidis clear away heat and detoxify, Brucea brucea, Purslane and Radix Isatidis are monarch drugs, Horsetail Herb, Raw Cyperus Rhizoma and Herba Patriniae soften and disperse stagnation and detoxify, Horsetail Herb, Raw Cyperus Rhizoma and Herba Patriniae are ministerial drugs, Lithospermum officinale and Carthamus tinctorius promote blood circulation and dissipate blood stasis, Lithospermum officinale and Carthamus tinctorius are adjuvant drugs, which can enhance the detoxification and dispersing stagnation power of the monarch and ministerial drugs and strengthen the drug permeability, and Glauber's salt disperses stagnation and eliminates accumulation, which is the guiding drug. Using the Chinese medicine composition provided by the present invention, the various Chinese medicines therein have the effects of detoxification and insecticide, softening and dispersing stagnation, promoting blood circulation and eliminating spots, and can be used as a therapeutic drug for viral warts.

[0008] The second aspect of the present invention provides an application of the traditional Chinese medicine composition described in the first aspect, that is, the traditional Chinese medicine composition is used for the preparation of a drug for treating viral warts, and the drug for treating viral warts is used to treat palmoplantar warts or periungual warts caused by HPV1, HPV2 or HPV4.

[0009] Preferably, the drug for treating viral warts is in the form of an ointment or a liniment.

[0010] The third aspect of the present invention provides a method for preparing the traditional Chinese medicine composition of the first aspect, comprising the following steps: mixing purslane, isatis root, horsetail herb, raw cyperus, lithospermum officinale, patrinia herb, safflower, sodium sulfate and brucea javanica, decocting the mixture for 30 to 60 minutes, mixing the medicinal soup and the medicinal residues to obtain a traditional Chinese medicine composition for treating viral warts.

[0011] The beneficial effects of the present invention are as follows: the Chinese medicine composition provided by the present invention adopts common Chinese medicinal materials, has a low preparation cost, has good anti-inflammatory and antiviral effects, and can regulate skin immune function while being used to treat viral warts. At the same time, the Chinese medicine composition provided by the present invention is used as an ointment or liniment, which is easy to use and can effectively prevent recurrence of the disease. DETAILED DESCRIPTION

[0012] In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below. It should be noted that the following embodiments are only used to illustrate the implementation method and typical parameters of the present invention, and are not used to limit the parameter range described in the present invention. Reasonable changes derived therefrom are still within the scope of protection of the claims of the present invention.

[0013] It should be noted that the endpoints and any values ​​of the ranges disclosed in this article are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of each range, the endpoint values ​​of each range and the individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, and these numerical ranges should be regarded as specifically disclosed in this article.

[0014] Unless otherwise defined, all terms, symbols and other scientific terms used herein are intended to have the same meaning as those commonly understood by those skilled in the art to which the present invention belongs. In some cases, terms with conventionally understood meanings are defined herein for the purpose of clarification or ease of reference, and such definitions herein should not be construed as indicating significant differences from conventional understandings in the art. The technical methods described or cited herein are generally well understood by those skilled in the art and are adopted by conventional methods. Unless otherwise stated, the use of commercially available kits, reagents and instruments is carried out in accordance with the protocols and parameters given by the manufacturer.

[0015] As described in the background art, in the prior art, the treatment of warts often has defects such as large side effects, easy recurrence of skin lesions, and large wounds. In view of this, a specific embodiment of the present invention provides a Chinese medicine composition with good therapeutic effect on warts and minimal side effects.

[0016] The Chinese medicine composition for treating viral warts provided in a specific embodiment of the present invention comprises the following components in parts by mass: 20-30 parts of purslane, 15-25 parts of isatis root, 25-35 parts of horsetail, 25-35 parts of raw cyperus, 5-15 parts of lithospermum, 5-15 parts of patrinia, 1-5 parts of safflower, 15-25 parts of sodium sulfate, and 5-15 parts of brucea javanica.

[0017] The Chinese medicine composition for treating viral warts provided in the above embodiment can be used for patients with viral warts of different age groups, especially those for whom freezing, laser and other treatments have poor effects or are prone to recurrence. It avoids local skin redness, swelling and damage after freezing and laser treatment, which affects life, and has good patient acceptance.

[0018] The technical solution of the present invention is further illustrated by specific embodiments below.

[0019] Example 1

[0020] A traditional Chinese medicine composition for treating viral warts comprises the following components, measured by mass: 30 parts of purslane, 20 parts of isatis root, 30 parts of horsetail, 30 parts of raw cyperus, 10 parts of lithospermum, 10 parts of patrinia, 3 parts of safflower, 20 parts of sodium sulfate and 10 parts of brucea javanica.

[0021] The Chinese medicinal materials in the above-mentioned parts by mass are mixed and concentratedly decocted for 30 minutes, and the medicinal soup and the medicinal residue are mixed to prepare a Chinese medicinal composition for treating viral warts.

[0022] Example 2

[0023] A traditional Chinese medicine composition for treating viral warts comprises the following components, measured by mass: 20 parts of purslane, 15 parts of isatis root, 25 parts of horsetail, 25 parts of raw cyperus, 5 parts of lithospermum, 5 parts of patrinia, 1 part of safflower, 15 parts of sodium sulfate and 5 parts of brucea javanica.

[0024] The Chinese medicinal materials in the above-mentioned parts by mass are mixed and concentratedly decocted for 50 minutes, and the medicinal soup and the medicinal residues are mixed to prepare a Chinese medicinal composition for treating viral warts.

[0025] Example 3

[0026] A traditional Chinese medicine composition for treating viral warts comprises the following components, measured by mass: 25 parts of purslane, 25 parts of isatis root, 35 parts of horsetail, 35 parts of raw cyperus, 15 parts of lithospermum, 15 parts of patrinia, 5 parts of safflower, 25 parts of sodium sulfate and 15 parts of brucea javanica.

[0027] The Chinese medicinal materials in the above-mentioned parts by mass are mixed and concentratedly decocted for 60 minutes, and the medicinal soup and the medicinal residues are mixed to prepare a Chinese medicinal composition for treating viral warts.

[0028] The method of using the Chinese medicine composition prepared in the above embodiment is as follows: the Chinese medicine composition is made into an ointment or a liniment, and one course of treatment is 2 weeks, and each time it is applied externally for 15 to 20 minutes, 1 to 2 times a day.

[0029] In order to demonstrate the efficacy of the above-mentioned Chinese medicine composition, a clinical comparison was conducted. A total of 47 patients used the above-mentioned Chinese medicine composition for three years. All cases were palmoplantar warts or periungual warts caused by HPV type 1, HPV type 2 or HPV type 4, including 30 cases of palmoplantar warts and 17 cases of periungual warts. The youngest was 6 years old and the oldest was 52 years old. The shortest course of disease was 1 month and the longest was 19 years.

[0030] The retrospective case analysis is as follows: Observation of indicators: After the patient visits the doctor, the size, thickness, number, pain, etc. of the warts on the affected part are first recorded. After each follow-up visit, the changes of the palm and plantar warts before and after the affected part (pain level, size, number, thickness, etc.) are recorded in detail. The scoring method is to accumulate points based on the clinical symptom classification. The scoring criteria for observation indicators are shown in Table 1.

[0031] Table 1

[0032] The clinical judgment standard for the treatment effect of palmoplantar warts refers to the judgment standard for the treatment effect of palmoplantar warts in the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes": Cure: Palmoplantar warts completely disappeared; Markedly effective: The number of palmoplantar warts decreased or their area decreased by 60% or more; Effective: The number of palmoplantar warts decreases or their area decreases by 30% or more, but less than 60%; Ineffective: The number of palmoplantar warts decreases or their area decreases by less than 30%, or increases or increases in size.

[0033] Total effective rate = (number of effective cases + number of markedly effective cases + number of cured cases) / total number of cases × 100%.

[0034] The calculation formula for comprehensive efficacy evaluation (nimodipine method) is: comprehensive efficacy = (total score before treatment - total score after treatment) / total score before treatment × 100%.

[0035] The clinical judgment standard for the treatment effect of periungual warts refers to the judgment standard for the treatment effect of periungual warts in the "Standards for Diagnosis and Efficacy of Chinese Medicine Diseases and Syndromes": Cure: periungual warts completely disappeared; Markedly effective: The number of periungual warts decreased or their area decreased by 60% or more; Effective: The number of periungual warts decreases or their area decreases by 30% or more, but less than 60%; Ineffective: The number of periungual warts decreases or their area decreases by less than 30%, or increases or increases in size.

[0036] Total effective rate = (number of effective cases + number of markedly effective cases + number of cured cases) / total number of cases × 100%.

[0037] The calculation formula for comprehensive efficacy evaluation (nimodipine method) is: comprehensive efficacy = (total score before treatment - total score after treatment) / total score before treatment × 100%.

[0038] Treatment group medication regimen: The Chinese medicine composition was made into an ointment or liniment, with one course of treatment being 2 weeks, applied externally for 15 to 20 minutes each time, 1 to 2 times a day.

[0039] The medication regimen for the control group: topical imizomod, three times a week, before bedtime, retaining for 6 to 10 hours, one course of treatment is 2 weeks.

[0040] The scores of various skin lesions in the two groups of palmoplantar warts before and after treatment are shown in Table 2.

[0041] Table 2

[0042] Note: Comparison within the same group after treatment and before treatment, ★ P < 0.05; after treatment, the two groups were compared, ☆ P < 0.05.

[0043] The overall efficacy evaluation of the two groups of palmoplantar warts after one month of treatment is shown in Table 3.

[0044] Table 3

[0045] The scores of skin lesions of the two groups of periungual warts before and after treatment are shown in Table 4.

[0046] Table 4

[0047] Note: Comparison within the same group after treatment and before treatment, ★ P< 0.05; after treatment, the two groups were compared, ☆ P < 0.05.

[0048] The overall efficacy evaluation of the two groups of periungual warts patients after one month of treatment is shown in Table 5.

[0049] Table 5

[0050] Adverse reaction observation: There was no obvious adverse reaction in the treatment group, and the patients accepted it well. Some patients in the control group experienced erythema and pain, which was relieved after adjusting the method of use. There was no recurrence in the Chinese medicine group after 2 months of follow-up.

[0051] Analysis and comparison: Compared with other methods, this compound Chinese medicine has a faster onset of effect, is applicable to a wide range of people, has no obvious skin irritation reaction, can effectively reduce the recurrence of warts, and enhance the skin's resistance to viruses.

[0052] It can be seen from the above examples that the Chinese medicine composition provided by the specific embodiment of the present invention has a good therapeutic effect on palmoplantar warts and periungual warts, and at the same time has the advantages of small side effects and low recurrence, and is an ideal medicine for treating palmoplantar warts and periungual warts.

[0053] Although the disclosure is disclosed as above, the protection scope of the disclosure is not limited thereto. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of the disclosure, and these changes and modifications will fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating viral warts, characterized in that: The invention comprises the following components by weight: 20-30 parts of purslane, 15-25 parts of isatis root, 25-35 parts of horsetail herb, 25-35 parts of raw cyperus, 5-15 parts of lithospermum officinale, 5-15 parts of patrinia herb, 1-5 parts of safflower, 15-25 parts of sodium sulfate and 5-15 parts of brucea frutescens.

2. The Chinese medicine composition according to claim 1, characterized in that The invention comprises the following components by weight: 30 parts of purslane, 20 parts of isatis root, 30 parts of horsetail herb, 30 parts of raw cyperus, 10 parts of lithospermum officinale, 10 parts of patrinia herb, 3 parts of safflower, 20 parts of sodium sulfate and 10 parts of brucea javanica.

3. An application of the Chinese medicine composition according to claim 1 or 2, characterized in that: The traditional Chinese medicine composition is used for the preparation of a drug for treating viral warts, and the drug for treating viral warts is used for treating palmoplantar warts or periungual warts caused by HPV1, HPV2 or HPV4.

4. The use according to claim 3, characterized in that The dosage form of the drug for treating viral warts is ointment or liniment.

5. A method for preparing the Chinese medicine composition according to claim 1 or 2, characterized in that: The following steps are involved: Purslane, Radix Isatidis, Herba Equisetifoliae, Rhizoma Cyperi, Lithospermum Officinale, Herba Patriniae, Carthamus Tinctorius, Sodium Sulfate and Fructus Bruceae are mixed and decocted for 30-60 minutes, and the decoction and residue are mixed to prepare a traditional Chinese medicine composition for treating viral warts.

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