Astaxanthin soft capsule and preparation process thereof

Abstract

The invention discloses an astaxanthin soft capsule and a preparation process thereof, and belongs to the technical field of functional food, the soft capsule comprises a capsule core and a capsule wall; the capsule core is prepared from the following components in parts by mass: 90 to 95 parts of astaxanthin oil, 60 to 64 parts of linseed oil, 8 to 12 parts of gamma-aminobutyric acid and 3 to 5 parts of beewax; the capsule wall comprises the following components in parts by mass: 36-40 parts of gelatin, 20-24 parts of glycerol, 5-7 parts of black pepper extract and 36-40 parts of purified water. The soft capsule obtained by processing the capsule core and capsule wall materials has the advantages of high stability and good disintegration effect.

Description

Technical Field

[0001] The invention belongs to the technical field of functional foods, and in particular relates to an astaxanthin soft capsule and a preparation process thereof. Background Art

[0002] Astaxanthin is the only carotenoid in nature that can pass through the human blood-brain barrier and has many physiological activities that are beneficial to human health. In recent years, astaxanthin has attracted much attention in the fields of food, medicine, biology, and cosmetics due to its strong antioxidant properties in its molecular structure.

[0003] Because astaxanthin products in capsule form have the advantages of easy transportation, easy carrying, controllable dosage, and good swallowing, most oral astaxanthin products use this dosage form.

[0004] The stability and bioavailability of astaxanthin capsules are affected by excipients and capsule walls. By adding existing excipients, soft capsules with controllable astaxanthin dosage and stable preparations can be made. However, the stability and disintegration rate can be further improved, thereby improving product quality. Summary of the invention

[0005] In order to overcome the problems existing in the prior art, the present invention provides an astaxanthin soft capsule and a preparation process thereof. The present invention improves the stability and bioavailability of astaxanthin in the capsule by optimizing the capsule wall formula.

[0006] To achieve the above-mentioned object, the first aspect of the present invention provides an astaxanthin soft capsule, comprising a capsule core and a capsule wall; The capsule core comprises the following components in parts by weight: 90-95 parts of astaxanthin oil, 60-64 parts of linseed oil, 8-12 parts of γ-aminobutyric acid, and 3-5 parts of beeswax; The capsule wall comprises the following components in parts by weight: 36-40 parts of gelatin, 20-24 parts of glycerol, 5-7 parts of black pepper extract, and 36-40 parts of purified water.

[0007] Further, it comprises a capsule core and a capsule wall; The capsule core contains the following components in parts by weight: 92 parts of astaxanthin oil, 62 parts of linseed oil, 10 parts of γ-aminobutyric acid, and 4 parts of beeswax; The capsule wall comprises the following components in parts by weight: 38 parts of gelatin, 22 parts of glycerol, 6 parts of black pepper extract, and 38 parts of purified water.

[0008] Further, it comprises a capsule core and a capsule wall; The capsule core contains the following components in parts by weight: 90 parts of astaxanthin oil, 60 parts of linseed oil, 8 parts of γ-aminobutyric acid, and 3 parts of beeswax; The capsule wall comprises the following components in parts by weight: 36 parts of gelatin, 20 parts of glycerol, 5 parts of black pepper extract, and 36 parts of purified water.

[0009] Further, it comprises a capsule core and a capsule wall; The capsule core contains the following components in parts by weight: 95 parts of astaxanthin oil, 64 parts of linseed oil, 12 parts of γ-aminobutyric acid, and 5 parts of beeswax; The capsule wall comprises the following components in parts by weight: 40 parts of gelatin, 24 parts of glycerol, 7 parts of black pepper extract, and 40 parts of purified water.

[0010] The second aspect of the present invention provides a method for preparing the astaxanthin soft capsule according to the first aspect, comprising the following steps: S1, adding 50%-60% of weighed linseed oil and beeswax into a container, stirring and heating to melt; cooling to 28-32°C, adding the remaining linseed oil, astaxanthin oil and γ-aminobutyric acid in sequence, and performing nano-treatment: mixing by high-speed shearing method, with a shearing time of 10-30 min and a shearing speed of 10000-15000 r / min, to obtain a suspension; S2, transferring the suspension obtained in step S1 into a batching tank for vacuuming to obtain capsule core material; S3, heat purified water to 80°C in a sol tank, add black pepper extract first, stir to dissolve, then add glycerin, mix well, and then heat to 80°C, turn on the vacuum pump, evacuate, keep stirring at a speed of 140-150rpm / min, and use a feed pipe to suck gelatin into the sol tank. After completion, close the feed valve and the vacuum pump, and continue stirring for 20 minutes; turn on the vacuum pump, evacuate and degas, continue stirring at a speed of 140-150rpm / min, and stop vacuum when the temperature drops below 60°C; heat the mixture to 60-65°C for standby use to obtain a capsule wall material; S4, encapsulating the capsule core material and the capsule wall material through a soft capsule making machine, wherein the capsule wall thickness is controlled to be 0.7-0.9 mm.

[0011] The third aspect of the present invention provides the use of the astaxanthin soft capsule described in the first aspect in the preparation of antioxidant medicines, health foods, functional foods, special medical foods, and special dietary foods.

[0012] Through the above technical scheme, the present invention can at least achieve the following beneficial effects: the present invention innovatively adds black pepper extract to the capsule wall raw material, which can reduce the fishy smell of astaxanthin and improve the stability and disintegration effect of astaxanthin soft capsules to a certain extent. DETAILED DESCRIPTION

[0013] Unless otherwise specified, the materials and reagents used in the present invention are commercially available.

[0014] In the present invention: Astaxanthin oil is extracted by our company (Yunnan Green A Bioengineering Co., Ltd.), and the astaxanthin content in astaxanthin oil is 5%.

[0015] Flaxseed oil was purchased from Heze Zhonghe Jianyuan Biotechnology Co., Ltd.; γ-Aminobutyric acid was purchased from Shandong Kangyou Biotechnology Co., Ltd. and passed through an 80-mesh sieve.

[0016] Beeswax was purchased from Cangzhou Dongfang Beeswax Glue Co., Ltd. Black pepper extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd. (water extract, specification 20:1); Gelatin was purchased from Kunming Sigui Economic and Trade Co., Ltd.; Glycerol was purchased from Jiangxi Yipsheng Pharmaceutical Co., Ltd.; Purified water is prepared by our company (Yunnan Green A Bioengineering Co., Ltd.). Embodiment 1

[0017] An astaxanthin soft capsule, comprising a capsule core and a capsule wall; The capsule core contains the following components in parts by weight: 92 parts of astaxanthin oil, 62 parts of linseed oil, 10 parts of γ-aminobutyric acid, and 4 parts of beeswax; The capsule wall comprises the following components in parts by weight: 38 parts of gelatin, 22 parts of glycerol, 6 parts of black pepper extract, and 38 parts of purified water.

[0018] The preparation method of the astaxanthin soft capsule comprises the following steps: S1, add 60% of the weighed linseed oil and beeswax into a container, stir and heat to melt; cool to 30°C, add the remaining linseed oil, astaxanthin and γ-aminobutyric acid in sequence, and use nano-treatment: high-speed shearing method mixing, shearing time 20 min, shearing speed 12000 r / min to obtain a suspension; S2, transferring the suspension obtained in step S1 into a batching tank for vacuuming (vacuum degree 0.07-0.08 MPa) to obtain capsule core material; S3, in a sol tank, heat purified water to 80°C, add black pepper extract first, stir to dissolve, then add glycerin, mix well, and then heat to 80°C, turn on the vacuum pump, evacuate, keep stirring at a speed of 140rpm / min, and use a feed pipe to suck gelatin into the sol tank. After completion, close the feed valve and the vacuum pump, and continue stirring for 20 minutes; turn on the vacuum pump, evacuate and degas, continue stirring at a speed of 140rpm / min, and stop vacuum when the temperature drops below 60°C; heat the mixture to 62°C for standby use to obtain a capsule wall material; S4, encapsulating the capsule core material and the capsule wall material through a soft capsule making machine, and controlling the capsule wall thickness to be 0.7-0.9 mm. Embodiment 2

[0019] An astaxanthin soft capsule, comprising a capsule core and a capsule wall; The capsule core contains the following components in parts by weight: 90 parts of astaxanthin oil, 60 parts of linseed oil, 8 parts of γ-aminobutyric acid, and 3 parts of beeswax; The capsule wall comprises the following components in parts by weight: 36 parts of gelatin, 20 parts of glycerol, 5 parts of black pepper extract, and 36 parts of purified water.

[0020] The preparation method of the astaxanthin soft capsule comprises the following steps: S1, add 50% of the weighed linseed oil and beeswax into a container, stir and heat to melt; cool to 28°C, add the remaining linseed oil, astaxanthin and γ-aminobutyric acid in sequence, and use nano-treatment: high-speed shearing method mixing, shearing time 10min, shearing speed 10000 r / min to obtain a suspension; S2, transferring the suspension obtained in step S1 into a batching tank for vacuuming (vacuum degree 0.07-0.08 MPa) to obtain capsule core material; S3, heat purified water to 80°C in a sol tank, add black pepper extract first, stir to dissolve, then add glycerin, mix well, and then heat to 80°C, turn on the vacuum pump, evacuate, keep stirring at a speed of 150rpm / min, and use a feed pipe to suck gelatin into the sol tank. After completion, close the feed valve and the vacuum pump, and continue stirring for 20 minutes; turn on the vacuum pump, evacuate to degas, continue stirring at a speed of 150rpm / min, and stop vacuuming when the temperature drops below 60°C; heat the mixture to 60°C for standby use to obtain a capsule wall material; S4, encapsulating the capsule core material and the capsule wall material through a soft capsule making machine, and controlling the capsule wall thickness to be 0.7-0.9 mm. Embodiment 3

[0021] An astaxanthin soft capsule, comprising a capsule core and a capsule wall; The capsule core contains the following components in parts by weight: 95 parts of astaxanthin oil, 64 parts of linseed oil, 12 parts of γ-aminobutyric acid, and 5 parts of beeswax; The capsule wall comprises the following components in parts by weight: 40 parts of gelatin, 24 parts of glycerol, 7 parts of black pepper extract, and 40 parts of purified water.

[0022] The preparation method of the astaxanthin soft capsule comprises the following steps: S1, add 60% of the weighed linseed oil and beeswax into a container, stir and heat to melt; cool to 28-32°C, add the remaining linseed oil, astaxanthin and γ-aminobutyric acid in sequence, and use nano-treatment: high-speed shearing method to mix, shear time min, shear speed 15000 r / min to obtain a suspension; S2, transferring the suspension obtained in step S1 into a batching tank for vacuuming (vacuum degree 0.07-0.08 MPa) to obtain capsule core material; S3, heat purified water to 80°C in a sol tank, add black pepper extract first, stir to dissolve, then add glycerin, mix well, and then heat to 80°C, turn on the vacuum pump, evacuate, keep stirring at a speed of 150rpm / min, and use a feed pipe to suck gelatin into the sol tank. After completion, close the feed valve and the vacuum pump, and continue stirring for 20 minutes; turn on the vacuum pump, evacuate to degas, continue stirring at a speed of 150rpm / min, and stop vacuum when the temperature drops below 60°C; heat the mixture to 65°C for standby use to obtain a capsule wall material; S4, encapsulating the capsule core material and the capsule wall material through a soft capsule making machine, wherein the capsule wall thickness is controlled to be 0.7-0.9 mm.

[0023] Comparative Example 1

[0024] The difference between Comparative Example 1 and Example 1 is that the capsule wall does not contain black pepper extract.

[0025] Experimental design: According to the guidelines for the stability test of raw materials and preparations (Chinese Pharmacopoeia 2020 Edition Part IV 9001), the raw material astaxanthin oil of the soft capsule of the present invention and the soft capsules prepared in Examples 1 to 3 and Comparative Example 1 were placed in clean brown glass bottles, set at a temperature of 40°C ± 2°C and a relative humidity of 75% ± 5% for 6 months, and samples were taken at 0 months, 1 month, 2 months, 3 months, and 6 months to detect the astaxanthin content in the product. The test results are shown in Table 1 below: Table 1 Product stability test results

[0026] After the soft capsules prepared in Examples 1 to 3 and Comparative Example 1 were stored at room temperature in clean brown glass bottles for 30 days, the disintegration time was tested in a 37°C water bath according to the disintegration time test method of the Chinese Pharmacopoeia 2020 edition, using water as the medium; 6 soft capsules were tested in parallel in each group, and the average value was taken to obtain the average disintegration time of the group.

[0027] The disintegration test results are shown in Table 2 below: Table 2 Product disintegration test results statistics

[0028] It can be seen from Table 2 above that the soft capsules prepared in Examples 1 to 3 have better disintegration effects in water than the soft capsules prepared in Comparative Example 1, and the soft capsules prepared in the present invention have excellent disintegration effects.

[0029] Finally, it should be noted that the above preferred embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made in form and details without departing from the scope defined by the claims of the present invention.

Claims

1. An astaxanthin soft capsule, characterized in that: It includes a capsule core and a capsule wall; The capsule core comprises the following components in parts by weight: 90-95 parts of astaxanthin oil, 60-64 parts of linseed oil, 8-12 parts of γ-aminobutyric acid, and 3-5 parts of beeswax; The capsule wall comprises the following components in parts by weight: 36-40 parts of gelatin, 20-24 parts of glycerol, 5-7 parts of black pepper extract, and 36-40 parts of purified water.

2. An astaxanthin soft capsule according to claim 1, characterized in that: It includes a capsule core and a capsule wall; The capsule core contains the following components in parts by weight: 92 parts of astaxanthin oil, 62 parts of linseed oil, 10 parts of γ-aminobutyric acid, and 4 parts of beeswax; The capsule wall comprises the following components in parts by weight: 38 parts of gelatin, 22 parts of glycerol, 6 parts of black pepper extract, and 38 parts of purified water.

3. An astaxanthin soft capsule according to claim 1, characterized in that: It includes a capsule core and a capsule wall; The capsule core contains the following components in parts by weight: 90 parts of astaxanthin oil, 60 parts of linseed oil, 8 parts of γ-aminobutyric acid, and 3 parts of beeswax; The capsule wall comprises the following components in parts by weight: 36 parts of gelatin, 20 parts of glycerol, 5 parts of black pepper extract, and 36 parts of purified water.

4. An astaxanthin soft capsule according to claim 1, characterized in that: It includes a capsule core and a capsule wall; The capsule core contains the following components in parts by weight: 95 parts of astaxanthin oil, 64 parts of linseed oil, 12 parts of γ-aminobutyric acid, and 5 parts of beeswax; The capsule wall comprises the following components in parts by weight: 40 parts of gelatin, 24 parts of glycerol, 7 parts of black pepper extract, and 40 parts of purified water.

5. The method for preparing the astaxanthin soft capsule according to any one of claims 1 to 4, characterized in that: The following steps are included: S1, adding 50%-60% of weighed linseed oil and beeswax into a container, stirring and heating to melt; cooling to 28-32°C, adding the remaining linseed oil, astaxanthin oil and γ-aminobutyric acid in sequence, and performing nano-treatment: mixing by high-speed shearing method, with a shearing time of 10-30 min and a shearing speed of 10000-15000 r / min, to obtain a suspension; S2, transferring the suspension obtained in step S1 into a batching tank for vacuuming to obtain capsule core material; S3, heat purified water to 80°C in a sol tank, add black pepper extract first, stir to dissolve, then add glycerin, mix well, and then heat to 80°C, turn on the vacuum pump, evacuate, keep stirring at a speed of 140-150rpm / min, and use a feed pipe to suck gelatin into the sol tank. After completion, close the feed valve and the vacuum pump, and continue stirring for 20 minutes; turn on the vacuum pump, evacuate and degas, continue stirring at a speed of 140-150rpm / min, and stop vacuum when the temperature drops below 60°C; heat the mixture to 60-65°C for standby use to obtain a capsule wall material; S4, encapsulating the capsule core material and the capsule wall material through a soft capsule making machine, wherein the capsule wall thickness is controlled to be 0.7-0.9 mm.

6. Use of the astaxanthin soft capsule according to any one of claims 1 to 4 in the preparation of antioxidant medicines, health foods, functional foods, special medical foods, and special dietary foods.

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