Composition containing extract and application of composition in preparation of product with freckle removing effect

Abstract

According to the preparation method of the extract-containing composition provided by the invention, various components such as an acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer, a hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, a verbascin extract, a paeonia lactiflora root extract and a platycodon grandiflorum root extract are added, so that the freckle removing performance of the composition is improved; the composition is applied to a freckle-removing product and has a good freckle-removing effect.

Description

Technical Field

[0001] The invention belongs to the technical field of freckle removing products, and specifically relates to a composition containing an extract and application of the composition in preparing a product with freckle removing effect. Background Art

[0002] Due to various factors such as age and environment, the pigmentation on the face is deposited on the surface of the skin, which will appear as various spots such as pigment spots, chloasma, sun spots or freckles. There are currently many ways to remove spots, mainly including skin care products, drug treatment, laser and light therapy, chemical peeling and other therapies. For example, skin care products: There are many skin care products on the market that contain whitening ingredients, such as vitamin C derivatives, niacinamide, arbutin, kojic acid, etc. They achieve the effect of lightening spots by inhibiting the production of melanin or accelerating the metabolism of melanin that has been produced. Sunscreen: Ultraviolet rays are one of the main causes of the formation of spots, so it is equally important to use high-efficiency sunscreen to prevent the formation of new spots. Oral medications: In some cases, doctors may recommend taking specific medications to regulate hormone levels in the body or enhance the skin's metabolic capacity to improve the condition of spots. Topical medications: Such as hydroquinone, retinoic acid drugs (Tretinoin), etc., are often used for local application to reduce pigmentation. Laser treatment: Use lasers of specific wavelengths to directly act on the deep layers of the skin, destroy cells that produce too much melanin, and promote the disappearance of spots. Common ones include Q-switched laser, picosecond laser, etc. Intense pulsed light (IPL): Also known as photorejuvenation, it can treat different types of spots, stimulate collagen proliferation and reduce pigmentation. Chemical peel: Use a certain concentration of acidic solution (such as fruit acid, salicylic acid, etc.) to apply to the face to remove aging keratinocytes on the surface, promote the growth of new cells, and help lighten spots. Microneedle therapy: Use tiny needles to create tiny channels on the skin to help active ingredients penetrate deeper into the skin, while stimulating collagen synthesis to help improve the problem of spots. Cryotherapy: Suitable for smaller areas of spots, using extremely low temperatures to freeze and destroy abnormal pigment cells.

[0003] Mechanical deep skin treatment, such as grinding, laser, freezing and chemical peeling, will inevitably damage the stratum corneum, reduce the skin's ability to resist external damage, and also cause excessive loss of skin moisture, making it very easy to age. Diet therapy contains a large amount of nutrients, vitamins and trace elements. Eating and applying it externally are very beneficial to increasing skin elasticity and moisturizing luster, but it is also a temporary solution and not a permanent cure.

[0004] As we age, skin problems are often more than just pigmentation. They are also accompanied by problems such as damaged sebum membrane, dry skin, fine lines or wrinkles. Current products only solve the problem of removing pigmentation, but cannot take into account dry skin, peeling, allergies, etc. Summary of the invention

[0005] The object of the present invention is to provide a preparation method of an extract-containing composition. By adding various components such as extracts during the preparation of the composition, it not only has good freckle-removing effects, but also moisturizes the skin and is non-irritating.

[0006] To achieve the above object, the present invention provides the following technical solutions: A preparation method of an extract-containing composition, comprising the following steps: S1: Mix 0.1 - 0.5 parts of p-hydroxyacetophenone, 0.01 - 0.1 parts of disodium EDTA and 5 - 10 parts of water evenly, then add 1 - 6 parts of 1,3-propanediol, 0.1 - 1 part of acrylate / C10 - 30 alkanol acrylate cross-linked polymer and 0.01 - 0.5 parts of xanthan gum thereto, stir and heat to 80 - 85 °C at a rotation speed of 20 - 30 r / min, homogenize for 3 - 6 min, and stir until completely dissolved to obtain a mixed solution A; S2: Mix 1 - 10 parts of caprylic / capric triglyceride, 1 - 10 parts of mineral oil, 0.5 - 8 parts of polydimethylsiloxane, 0.1 - 3 parts of cetearyl alcohol, 0.1 - 5 parts of squalane, 0.1 - 5 parts of macadamia seed oil, 0.001 - 0.2 parts of glabridin, 1 - 5 parts of component A and 1 - 5 parts of component B, stir and heat to 85 - 90 °C at a rate of 20 - 30 r / min, and stir until completely dissolved to obtain a mixed solution B; S3: Add the mixed solution B obtained in step S2 to the mixed solution A obtained in step S1, stir at a rotation speed of 30 - 50 r / min, homogenize for 5 - 8 min, and keep warm for 30 min; S4: Add 0.1 - 2 parts of component C to step S3, homogenize for 3 min, and stir evenly; cool down to 60 °C, add 0.1 - 1 part of arginine and 3 - 5 parts of water, and stir evenly; then add 1 - 10 parts of glycerol, 0.001 - 0.2 parts of 4-butylresorcinol and 0.001 - 0.2 parts of phenylethylresorcinol, and stir evenly; S5: Cool down to 45 °C, add 0.1 - 2 parts of bis-PEG-18 methyl ether dimethylsilane and 3 - 6 parts of water, and stir evenly; then add 1 - 5 parts of niacinamide, 0.01 - 2 parts of 3-O-ethylascorbic acid, 0.01 - 2 parts of tranexamic acid and 5 - 8 parts of water, and stir evenly; S6: Then add 0.5 - 5 parts of component D, 0.3 - 3 parts of component E, 0.3 - 3 parts of component F, 0.1 - 0.5 parts of component G and 0.1 - 0.5 parts of squalane, and stir evenly to obtain the extract-containing composition.

[0007] Further, the preparation process of the acrylate / C10-30 alkyl acrylate cross-linked polymer in step S1 is as follows: Take 10-20 parts of acrylate, 15-20 parts of C10-30 alkyl acrylate, 1-3 parts of N,N'-methylenebisacrylamide, 1.5-2.5 parts of azobisisobutyronitrile, and 20-40 parts of acetone, and react at a temperature of 110-120 °C for 1-2 h to obtain the cross-linked polymer.

[0008] Further, in step S2, component A includes 5-10 parts of cetearyl glucoside and 3-8 parts of cetearyl alcohol; component B includes 5-10 parts of PEG-100 stearate and 4-8 parts of glyceryl stearate.

[0009] Further, in step S4, component C includes 10-15 parts of hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, 1-3 parts of squalane, 2-5 parts of polysorbate-60, 20-30 parts of water, and 4-8 parts of sorbitan isostearate.

[0010] Further, the preparation process of the hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer is as follows: Take 15-25 parts of hydroxyethyl acrylate, 10-20 parts of sodium acryloyldimethyltaurate, 1-3 parts of potassium sulfate, 2-4 parts of mercaptoethanol, and 25-35 parts of glycerol, mix them, and react at a temperature of 80-90 °C for 1-3 h under nitrogen protection to obtain the copolymer.

[0011] Further, in step S6, component D includes 2-4 parts of glycerol, 6-10 parts of verbascum extract, 3-7 parts of citric acid, 1-3 parts of sodium benzoate, and 2-5 parts of potassium sorbate; component E includes 10-20 parts of water, 2-4 parts of butanediol, 3-6 parts of 1,2-hexanediol, and 8-10 parts of peony root extract.

[0012] Further, the preparation process of the verbascum extract is as follows: Take 15 parts of verbascum, crush it to 50-60 mesh, add 150 parts of deionized water thereto, stir and mix for 30 min; heat up to 60 °C, add 0.1 part of cellulase and enzymolyze for 1.5 h; then add 1.5 parts of konjac glucomannan thereto, mix well, put it into a soft cooking bag, vacuum package it, and treat it at 500 MPa for 35 min to obtain the extract.

[0013] Further, the preparation process of the peony root extract is as follows: Weigh the crushed peony root, add deionized water thereto according to a solid-liquid ratio of 1:10-105, decoct for 1-2 h to obtain an extraction solution; then add tannase, control the pH of the solution to 5-6, perform ultrasonic extraction at a temperature of 60 °C and 400 W for 1-2 h, and filter the residue to obtain the peony root extract.

[0014] Further, the component F described in step S6 includes 4-6 parts of glycerol, 10-20 parts of water, 5-10 parts of platycodon root extract, and 2-4 parts of maltodextrin; the component G includes 3-7 parts of 1,3-propanediol, 5-10 parts of 1,2-hexanediol, and 2-6 parts of octanoyl hydroxamic acid.

[0015] Further, the preparation process of the platycodon root extract is as follows: Take the crushed fresh platycodon root, perform microwave-assisted treatment, with a material-liquid ratio of 1:30 and an ethanol concentration of 70%. According to a solid-liquid ratio of 1:20, add an ethanol solution with a mass fraction of 70% thereto, microwave for 120 s at a power of 400 W, and filter the residue to obtain the platycodon root extract.

[0016] Compared with the prior art, the advantages and beneficial effects of the present invention are as follows: The present invention adds various components such as self-made acrylate / C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, verbascum extract, paeonia root extract, and platycodon root extract to the composition. By inhibiting tyrosinase, the formation of melanin is reduced, thereby lightening age spots; accelerating the epidermal cell renewal process, removing aging cutin cells containing excessive melanin, making the skin look brighter and more uniform; by neutralizing free radicals, reducing the oxidative stress response caused by environmental factors (such as ultraviolet radiation), preventing the formation of new age spots and improving existing age spots; strengthening the skin barrier to improve the skin's resistance to external stimuli, indirectly supporting the skin's self-repair ability, and facilitating the fading of age spots; through the above comprehensive effects, the freckle-removing ability is significantly improved, and it does not irritate the skin and has a good moisturizing effect. Specific embodiments

[0017] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0018] All raw materials used in the present invention are purchased conventionally.

[0019] Example 1 This example provides a preparation method of an extract-containing composition, including the following steps: S1: Take 10 g of acrylate, 15 g of C10-30 alkyl acrylate, 1 g of N,N'-methylenebisacrylamide, 1.5 g of azobisisobutyronitrile, and 20 g of acetone, react at a temperature of 110 °C for 1 h to obtain acrylate / C10-30 alkyl acrylate cross-linked polymer; Mix 0.1 g of 4-Hydroxyacetophenone, 0.01 g of Disodium EDTA and 5 g of water evenly, then add 1 g of 1,3-Propanediol, 0.1 g of Acrylates / C10-30 Alkyl Acrylate Crosspolymer and 0.01 g of Xanthan Gum thereto, stir and heat to 80 °C at a rotation speed of 20 r / min, homogenize for 3 min, and stir until completely dissolved to obtain mixture A; S2: Take 5 g of Cetearyl Glucoside and 3 g of Cetearyl Alcohol, stir and mix them evenly to obtain component A; take 5 g of PEG-100 Stearate and 4 g of Glyceryl Stearate, stir and mix them evenly to obtain component B; mix 1 g of Caprylic / Capric Triglyceride, 1 g of Mineral Oil, 0.5 g of Polydimethylsiloxane, 0.1 g of Cetearyl Alcohol, 0.1 g of Squalane, 0.1 g of Macadamia Seed Oil, 0.001 g of Glabridin, 1 g of component A and 1 g of component B, stir and heat to 85 °C at a rate of 20 / min, and stir until completely dissolved to obtain mixture B; S3: Add the mixture B obtained in step S2 to the mixture A obtained in step S1, stir at a rotation speed of 30 r / min, homogenize for 5 min, and keep warm for 30 min; S4: Take 10 g of Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, 1 g of Squalane, 2 g of Polysorbate-60, 20 g of water and 4 g of Sorbitan Isostearate, stir them evenly to obtain component C; Add 0.1 g of component C to step S3, homogenize for 3 min, and stir evenly; cool down to 60 °C, add 0.1 g of Arginine and 3 g of water, and stir evenly; then add 1 g of Glycerol, 0.001 g of 4-Butylresorcinol and 0.001 g of Phenylethyl Resorcinol, and stir evenly; S5: Cool down to 45 °C, add 0.1 g of Bis-PEG-18 Methyl Ether Dimethicone and 3 - 6 g of water, and stir evenly; then add 1 g of Niacinamide, 0.01 g of 3-O-Ethyl Ascorbic Acid, 0.01 g of Tranexamic Acid and 5 g of water, and stir evenly; S6: Grind 15 g of Verbascum thapsus to 50 - 60 meshes, add 150 g of deionized water thereto, stir and mix for 30 min; heat up to 60 °C, add 0.1 g of Cellulase and enzymolyze for 1.5 h; then add 1.5 g of Konjac Glucomannan thereto, mix evenly, put it into a soft cooking bag, vacuum package it, and treat it at 500 MPa for 35 min to obtain Verbascum thapsus extract; Weigh the crushed peony roots, add deionized water thereto according to a solid-liquid ratio of 1:10, decoct for 1 h to obtain an extraction solution; then add tannase, control the solution pH to 5 - 6, perform ultrasonic extraction at a temperature of 60 °C and 400 W for 1 h, and filter the residue to obtain peony root extraction solution; Take 2 g of glycerol, 6 g of verbascum extract, 3 g of citric acid, 1 g of sodium benzoate and 2 g of potassium sorbate, stir well to obtain Component D; take 10 g of water, 2 g of butanediol, 3 g of 1,2 - hexanediol and 8 g of peony root extract, stir well to obtain Component E; Take the crushed fresh platycodon root, carry out microwave - assisted treatment, the solid - liquid ratio is 1:30, the ethanol concentration is 70%, according to the solid - liquid ratio of 1:20, add an ethanol solution with a mass fraction of 70% to it, microwave for 120 s at a power of 400 W, filter the residue, and the platycodon root extract can be obtained; Take 4 g of glycerol, 10 g of water, 5 g of platycodon root extract and 2 g of maltodextrin, stir well to obtain Component F; take 3 g of 1,3 - propanediol, 5 g of 1,2 - hexanediol and 2 g of octanoyl hydroxamic acid, stir well to obtain Component G; Then add 0.5 g of Component D, 0.3 g of Component E, 0.3 g of Component F, 0.1 g of Component G and 0.1 g of squalane, stir well, and the extract - containing composition is obtained.

[0020] Example 2 This example provides a preparation method of an extract - containing composition, which includes the following steps: S1: Take 20 g of acrylate, 20 g of C10 - 30 alkyl acrylate, 3 g of N,N'-methylenebisacrylamide, 2.5 g of azobisisobutyronitrile and 40 g of acetone, react at a temperature of 120 °C for 2 h to obtain an acrylate / C10 - 30 alkyl acrylate cross - linked polymer; Mix 0.5 g of p - hydroxyacetophenone, 0.1 g of disodium EDTA and 10 g of water evenly, then add 6 g of 1,3 - propanediol, 1 g of acrylate / C10 - 30 alkyl acrylate cross - linked polymer and 0.5 g of xanthan gum to it, stir and heat to 85 °C at a rotation speed of 30 r / min, homogenize for 6 min, and stir until completely dissolved to obtain a mixed solution A; S2: Take 10 g of cetearyl glucoside and 8 g of cetearyl alcohol, stir and mix until uniform to obtain Component A; take 10 g of PEG - 100 stearate and 8 g of glyceryl stearate, stir and mix evenly to obtain Component B; mix 10 g of caprylic / capric triglyceride, 10 g of mineral oil, 8 g of polydimethylsiloxane, 3 g of cetearyl alcohol, 5 g of squalane, 5 g of macadamia nut oil, 0.2 g of glabridin, 5 g of Component A and 5 g of Component B, stir and heat to 90 °C at a rate of 30 r / min, and stir until completely dissolved to obtain a mixed solution B; S3: Add the mixed solution B obtained in step S2 to the mixed solution A obtained in step S1, stir at a rotation speed of 50 r / min, homogenize for 8 min, and keep warm for 30 min; S4: Take 15 g of acryloyldimethyltaurate / VP copolymer, 3 g of squalane, 5 g of polysorbate - 60, 30 g of water and 8 g of sorbitan isostearate, stir evenly to obtain Component C; Add 2 g of Component C to Step S3, homogenize for 3 min, and stir evenly; cool down to 60 °C, add 1 g of arginine and 5 g of water, and stir evenly; then add 10 g of glycerol, 0.2 g of 4 - butylresorcinol and 0.2 g of phenethylresorcinol, and stir evenly; S5: Cool down to 45 °C, add 2 g of bis - PEG - 18 methyl ether dimethicone and 6 g of water, and stir evenly; then add 5 g of niacinamide, 2 g of 3 - O - ethyl ascorbic acid, 2 g of tranexamic acid and 8 g of water, and stir evenly; S6: Take 15 g of verbascum flower, crush it to 50 - 60 mesh, add 150 g of deionized water thereto, stir and mix for 30 min; heat up to 60 °C, add 0.1 g of cellulase and enzymolyze for 1.5 h; then add 1.5 g of konjac glucomannan thereto, mix evenly, put it into a soft cooking bag, vacuum package it, and treat it at 500 MPa for 35 min to obtain verbascum flower extract; Weigh the crushed peony root, add deionized water thereto according to the solid - liquid ratio of 1:15, decoct for 2 h to obtain an extraction solution; then add tannase, control the pH of the solution to be 5 - 6, carry out ultrasonic extraction at 60 °C and 400 W for 2 h, and filter the residue to obtain peony root extract; Take 4 g of glycerol, 10 g of verbascum flower extract, 7 g of citric acid, 3 g of sodium benzoate and 5 g of potassium sorbate, stir evenly to obtain Component D; take 20 g of water, 4 g of butanediol, 6 g of 1,2 - hexanediol and 10 g of peony root extract, stir evenly to obtain Component E; Take the crushed fresh platycodon root, carry out microwave - assisted treatment, with the solid - liquid ratio of 1:30 and the ethanol concentration of 70%, add a 70% ethanol solution thereto according to the solid - liquid ratio of 1:20, microwave at a power of 400 W for 120 s, filter the residue, and thus obtain the platycodon root extract; Take 6 g of glycerol, 20 g of water, 10 g of platycodon root extract and 4 g of maltodextrin, stir evenly to obtain Component F; take 7 g of 1,3 - propanediol, 10 g of 1,2 - hexanediol and 6 g of octanoyl hydroxamic acid, stir evenly to obtain Component G; Then add 5 g of Component D, 3 g of Component E, 3 g of Component F, 0.5 g of Component G and 5 g of squalane, stir evenly, and thus obtain the extract - containing composition.

[0021] Example 3 This example provides a preparation method of an extract - containing composition, including the following steps: S1: Take 15 g of acrylate, 17 g of C10-30 alkyl acrylate, 2 g of N,N'-methylenebisacrylamide, 2 g of azobisisobutyronitrile, and 30 g of acetone, react at a temperature of 115 °C for 2 h to obtain an acrylate / C10-30 alkyl acrylate cross-linked polymer; Mix 0.3 g of p-hydroxyacetophenone, 0.05 g of disodium EDTA, and 7 g of water evenly, then add 4 g of 1,3-propanediol, 0.6 g of acrylate / C10-30 alkyl acrylate cross-linked polymer, and 0.35 g of xanthan gum thereto, stir and heat to 82 °C at a rotation speed of 25 r / min, homogenize for 5 min, and stir until completely dissolved to obtain mixture A; S2: Take 7 g of cetearyl glucoside and 5 g of cetearyl alcohol, stir and mix them evenly to obtain component A; take 7 g of PEG-100 stearate and 6 g of glyceryl stearate, stir and mix them evenly to obtain component B; mix 5 g of caprylic / capric triglyceride, 4 g of mineral oil, 5 g of polydimethylsiloxane, 2 g of cetearyl alcohol, 2.5 g of squalane, 4 g of macadamia seed oil, 0.12 g of glabridin, 2 g of component A, and 3 g of component B, stir and heat to 88 °C at a rate of 25 r / min, and stir until completely dissolved to obtain mixture B; S3: Add the mixture B obtained in step S2 to the mixture A obtained in step S1, stir at a rotation speed of 40 r / min, homogenize for 6 min, and keep warm for 30 min; S4: Take 12 g of hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, 2 g of squalane, 3 g of polysorbate-60, 25 g of water, and 6 g of sorbitan isostearate, stir them evenly to obtain component C; Add 1 g of component C to step S3, homogenize for 3 min, and stir evenly; cool down to 60 °C, add 0.5 g of arginine and 4 g of water, and stir evenly; then add 5 g of glycerol, 0.12 g of 4-butylresorcinol, and 0.1 g of phenethyl resorcinol, and stir evenly; S5: Cool down to 45 °C, add 1 g of bis-PEG-18 methyl ether dimethylsilane and 4 g of water, and stir evenly; then add 3 g of niacinamide, 0.7 g of 3-O-ethylascorbic acid, 1 g of tranexamic acid, and 6 g of water, and stir evenly; S6: Take 15 g of verbascum, crush it to 50-60 mesh, add 150 g of deionized water thereto, stir and mix for 30 min; heat up to 60 °C, add 0.1 g of cellulase, and enzymolyze for 1.5 h; then add 1.5 g of konjac glucomannan thereto, mix evenly, put it into a soft cooking bag, vacuum package it, and treat it at 500 MPa for 35 min to obtain a verbascum extract; Weigh the pulverized peony roots, add deionized water to them according to a solid-liquid ratio of 1:12, decoct for 1.5 h to obtain an extract; then add tannase, control the pH of the solution to be 5-6, and perform ultrasonic extraction at a temperature of 60 °C and 400 W for 1 h. After filtering the residue, the peony root extract is obtained; Take 3 g of glycerol, 8 g of verbascum extract, 5 g of citric acid, 2 g of sodium benzoate and 3 g of potassium sorbate, stir evenly to obtain Component D; take 15 g of water, 3 g of butanediol, 5 g of 1,2-hexanediol and 9 g of peony root extract, stir evenly to obtain the said Component E; Take the pulverized fresh platycodon roots, perform microwave-assisted treatment, with a solid-liquid ratio of 1:30 and an ethanol concentration of 70%. According to a solid-liquid ratio of 1:20, add an ethanol solution with a mass fraction of 70% to it, microwave at a power of 400 W for 120 s, filter the residue, and the platycodon root extract can be obtained; Take 5 g of glycerol, 15 g of water, 7 g of platycodon root extract and 3 g of maltodextrin, stir evenly to obtain Component F; take 5 g of 1,3-propanediol, 8 g of 1,2-hexanediol and 4 g of octanoyl hydroxamic acid, stir evenly to obtain Component G; Then add 3 g of Component D, 2 g of Component E, 2 g of Component F, 0.3 g of Component G and 3 g of squalane, stir evenly, and the extract-containing composition is obtained.

[0022] Comparative Example 1 The difference between this comparative example and Example 1 is that: in step S1, polyacrylate / C10-30 alkyl acrylate crosslinked polymer is missing, and other steps are the same.

[0023] Comparative Example 2 The difference between this comparative example and Example 1 is that: in step S4, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer is missing, and other steps are the same.

[0024] Comparative Example 3 The difference between this comparative example and Example 1 is that: in step S6, verbascum extract is missing, and other steps are the same.

[0025] Comparative Example 4 The difference between this comparative example and Example 1 is that: in step S6, peony root extract is missing, and other steps are the same.

[0026] Comparative Example 5 The difference between this comparative example and Example 1 is that: in step S6, platycodon root extract is missing, and other steps are the same.

[0027] Take 50 g of the compositions obtained in each example and comparative example, 30 g of deionized water, 5 g of hydroxyethyl cellulose, 6 g of chitin and 2 g of 1,3-butanediol, mix them, heat to 85 °C, stir until it becomes transparent, and adjust the pH value of the solution to 5.0-6.0 with citric acid to obtain the freckle-removing product.

[0028] Performance test: Determination of tyrosinase activity: Take 0.47 mL of tyrosine solution, 0.5 mL of the sample solution of the freckle-removing products prepared from each of the tested examples and comparative examples, and 0.28 mL of PBS (pH = 6.8) buffer solution. After preheating at 37 °C for 10 min, add 0.25 mL of tyrosinase solution and mix well, then keep it in a water bath at 37 °C for 10 min. Measure the absorbance value at a wavelength of 475 nm. Use the PBS buffer solution instead of the tested sample as the blank group, and use arbutin (1 mg / mL) as the positive control. Repeat the experiment three times and take the average value. Use (absorbance value of the sample group / absorbance value of the blank group) × 100% to represent the tyrosinase activity. The results are shown in the following table: Table 1 Performance test results

[0029] As can be seen from the above performance test results, Examples 1-3 showed good freckle-removing and other properties under the synergistic effect of each component; especially the comprehensive performance of Example 3 was the most prominent. While Comparative Examples 1-5 did not adopt the necessary technical solutions, resulting in their significantly worse performance in the corresponding performance tests than the examples. The above experimental results further prove the importance of the technical solutions defined in the present invention for its technical effects.

[0030] The above is the preferred embodiment of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A method for preparing an extract composition, characterized in that: The steps include: S1: 0.1-0.5 parts of p-hydroxyacetophenone, 0.01-0.1 parts of disodium EDTA and 5-10 parts of water are mixed evenly, and then 1-6 parts of 1,3-propylene glycol, 0.1-1 parts of acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer and 0.01-0.5 parts of xanthan gum are added thereto, and heated to 80-85°C at a speed of 20-30 r / min with stirring, and homogenized for 3-6 minutes, and stirred to dissolve completely to obtain a mixed solution A; S2: 1-10 parts of caprylic / capric triglyceride, 1-10 parts of mineral oil, 0.5-8 parts of polydimethylsiloxane, 0.1-3 parts of cetearyl alcohol, 0.1-5 parts of squalane, 0.1-5 parts of macadamia seed oil, 0.001-0.2 parts of glabridin, 1-5 parts of component A and 1-5 parts of component B are mixed, and heated to 85-90° C. at a rate of 20-30 r / min with stirring, and stirred until completely dissolved to obtain a mixed solution B; S3: Add the mixed solution B obtained in step S2 to the mixed solution A obtained in step S1, stir at a speed of 30-50 r / min, homogenize for 5-8 minutes, and keep warm for 30 minutes; S4: add 0.1-2 parts of component C to step S3, homogenize for 3 minutes, and stir evenly; cool to 60°C, add 0.1-1 parts of arginine and 3-5 parts of water, and stir evenly; then add 1-10 parts of glycerol, 0.001-0.2 parts of 4-butylresorcinol and 0.001-0.2 parts of phenylethylresorcinol, and stir evenly; S5: Cool down to 45°C, add 0.1-2 parts of bis-PEG-18 methyl ether dimethyl silane and 3-6 parts of water, and stir evenly; then add 1-5 parts of niacinamide, 0.01-2 parts of 3-o-ethyl ascorbic acid, 0.01-2 parts of tranexamic acid and 5-8 parts of water, and stir evenly; S6: Add 0.5-5 parts of component D, 0.3-3 parts of component E, 0.3-3 parts of component F, 0.1-0.5 parts of component G and squalane, and stir evenly to obtain the extract-containing composition.

2. The method for preparing an extract composition according to claim 1, characterized in that: The preparation process of acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer in step S1 is: take 10-20 parts of acrylic acid ester, 15-20 parts of C10-30 alkyl acrylate, 1-3 parts of N,N'-methylenebisacrylamide, 1.5-2.5 parts of azobisisobutyronitrile and 20-40 parts of acetone, react at a temperature of 110-120°C for 1-2h to obtain the cross-linked polymer.

3. The method for preparing an extract composition according to claim 1, characterized in that: In step S2, component A includes 5-10 parts of cetearyl glucoside and 3-8 parts of cetearyl alcohol; component B includes 5-10 parts of PEG-100 stearate and 4-8 parts of glyceryl stearate.

4. The method for preparing an extract composition according to claim 1, characterized in that: In step S4, component C includes 10-15 parts of hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, 1-3 parts of squalane, 2-5 parts of polysorbate-60, 20-30 parts of water and 4-8 parts of sorbitan isostearate.

5. The method for preparing an extract composition according to claim 4, characterized in that: The preparation process of the hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer is as follows: 15-25 parts of hydroxyethyl acrylate, 10-20 parts of sodium acryloyldimethyl taurate, 1-3 parts of potassium sulfate, 2-4 parts of mercaptoethanol and 25-35 parts of propylene glycol are mixed, and the mixture is reacted at a temperature of 80-90° C. for 1-3 hours under nitrogen protection to obtain the copolymer.

6. The method for preparing an extract composition according to claim 1, characterized in that: In step S6, component D comprises 2-4 parts of glycerin, 6-10 parts of mullein extract, 3-7 parts of citric acid, 1-3 parts of sodium benzoate and 2-5 parts of potassium sorbate; and component E comprises 10-20 parts of water, 2-4 parts of butylene glycol, 3-6 parts of 1,2-hexanediol and 8-10 parts of peony root extract.

7. The method for preparing an extract composition according to claim 6, characterized in that: The preparation process of the mullein extract is as follows: 15 parts of mullein are crushed into 50-60 meshes, 150 parts of deionized water are added thereto, and the mixture is stirred for 30 minutes; the temperature is raised to 60°C, 0.1 parts of cellulase is added thereto for enzymolysis for 1.5 hours; 1.5 parts of konjac glucomannan are added thereto, the mixture is mixed and then put into a soft cooking bag, vacuum-packed, and treated at 500 MPa for 35 minutes to obtain the extract.

8. The method for preparing an extract composition according to claim 6, characterized in that: The preparation process of the peony root extract is as follows: weigh the crushed peony root, add deionized water thereto according to a solid-liquid ratio of 1:10-105, and boil for 1-2 hours to obtain an extract; then add tannase, control the pH of the solution to 5-6, perform ultrasonic extraction at a temperature of 60°C and 400W for 1-2 hours, filter the residue, and obtain the peony root extract.

9. The method for preparing an extract composition according to claim 1, characterized in that: In step S6, the component F comprises 4-6 parts of glycerin, 10-20 parts of water, 5-10 parts of platycodon root extract and 2-4 parts of maltodextrin; the component G comprises 3-7 parts of 1,3-propylene glycol, 5-10 parts of 1,2-hexanediol and 2-6 parts of caprylhydroxamic acid.

10. The method for preparing an extract composition according to claim 9, characterized in that: The preparation process of the Platycodon grandiflorum root extract is as follows: taking crushed fresh Platycodon grandiflorum root, performing microwave-assisted treatment, wherein the solid-liquid ratio is 1:30, the ethanol concentration is 70%, and according to the solid-liquid ratio of 1:20, adding a 70% by mass ethanol solution thereto, microwave at a power of 400 W for 120 seconds, filtering the residue, and thus obtaining the Platycodon grandiflorum root extract.

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