Traditional Chinese medicine composite plaster for treating meridian block type pain and numbness and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compound plasters, in particular to a traditional Chinese medicine compound plaster for treating meridian blocking type pain and numbness. Comprising the following components: 10 to 30 g of pseudo-ginseng, 10 to 25 g of lycopodium clavatum, 10 to 25 g of flos daturae, 10 to 30 g of radix clematidis, 10 to 20 g of ligusticum wallichii, 10 to 25 g of radix angelicae pubescentis, 10 to 30 g of angelica sinensis, 10 to 30 g of ginger, 10 to 30 g of radix salviae miltiorrhizae, 10 to 30 g of clove, 10 to 20 g of radix achyranthis bidentatae, 10 to 20 g of teasel root, 10 to 25 g of trogopterus dung, 10 to 25 g of safflower, 10 to 25 g of fenugreek, 10 to 30 g of fructus psoraleae, 10 to 25 g of dragon's blood, 10 to 30 g of corydalis tuber, 10 to 30 g of earthworm, 10 to 30 g of asarum, 10 to 25 g of frankincense, 10 The invention solves the problem that the damaged part is difficult to completely or mostly recover by the traditional treatment, and after the patient recovers, the recurrence probability is obviously reduced as long as the patient needs to pay attention to maintenance, a long-acting and stable treatment effect is provided for the patient, the burden of repeated treatment is relieved, the plaster covers the painful and numbness part after being heated, and the area of the plaster exceeds twice of that of the part, so that the curative effect is obvious. The medicine action range can be expanded, the damaged area is fully covered, and the treatment effect is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compound plasters, and particularly to a traditional Chinese medicine compound plaster for treating pain and numbness caused by meridian blockage and a preparation method thereof. Background Art

[0002] In modern society, with the improvement of people's health awareness, the number of people participating in sports has been continuously increasing. However, accidents frequently occur during sports, resulting in a high incidence of sports injuries. According to relevant statistical data, among people who often participate in sports, the incidence of sports injuries can reach 30%-50% annually. Among them, pain and numbness symptoms caused by sports injuries are extremely common, seriously affecting the quality of life and sports ability of patients.

[0003] At present, for the pain and numbness caused by sports injuries, clinical treatment mainly adopts traditional treatment means such as acupuncture, electrotherapy, cupping, and massage. Acupuncture stimulates human acupoints to regulate the flow of qi and blood to achieve the effects of relieving pain and numbness; electrotherapy uses electric current stimulation to promote local blood circulation and reduce inflammatory reactions; cupping uses the principle of negative pressure adsorption to improve muscle spasm; massage uses manual massage to dredge meridians and relieve pain. Using the above means can solve various pains caused by sports injuries in the human body, but it can only relieve numbness and cannot completely or mostly restore the damaged parts to their original state, with a relatively high recurrence rate.

[0004] Therefore, aiming at the problem that the above traditional Chinese medicine compound plaster can only relieve numbness and cannot effectively repair the damaged parts caused by sports injuries and make the damaged parts completely or mostly return to their original state, a traditional Chinese medicine compound plaster for treating pain and numbness caused by meridian blockage and a preparation method thereof can be designed. Summary of the Invention

[0005] In order to overcome the problem that traditional Chinese medicine compound plasters can only relieve numbness and cannot effectively repair the damaged parts caused by sports injuries and make the damaged parts completely or mostly return to their original state.

[0006] The technical solution of the present invention is as follows: A traditional Chinese medicine compound plaster for treating pain and numbness caused by meridian blockage, comprising the following components: 10-30 g of Panax notoginseng, 10-25 g of Lycopodium clavatum, 10-25 g of Datura metel, 10-30 g of Clematis chinensis, 10-20 g of Ligusticum chuanxiong, 10-25 g of Angelica pubescens, 10-30 g of Angelica sinensis, 10-30 g of Zingiber officinale, 10-30 g of Salvia miltiorrhiza, 10-30 g of Syzygium aromaticum, 10-20 g of Achyranthes bidentata, 10-20 g of Dipsacus asperoides, 10-25 g of Trogopterus dung, 10-25 g of Carthamus tinctorius, 10-25 g of Ledebouriella seseloides, 10-30 g of Psoralea corylifolia, 10-25 g of Sanguis draxonis, 10-30 g of Corydalis yanhusuo, 10-30 g of Pheretima aspergillum, 10-30 g of Asarum sieboldii, 10-25 g of Olibanum, 10-20 g of Myrrha, 10-30 g of Borneol, 10-30 g of Menthol, 10-20 g of Azone, 20-30 g of hot melt adhesive.

[0007] Preferably, the Panax notoginseng is specifically Chun Panax notoginseng with a saponin content of not less than 6%.

[0008] Preferably, the Lycopodium clavatum is specifically Lycopodium clavatum that is naturally sun-dried and has a water content between 12% and 15%.

[0009] A preparation method of a traditional Chinese medicine compound plaster for treating pain and numbness caused by meridian blockage, which comprises a traditional Chinese medicine compound plaster for treating pain and numbness caused by meridian blockage as described above, and the steps are as follows:

[0010] S1: Pretreatment of medicinal materials

[0011] According to the formula, accurately weigh the weight of each Chinese medicinal material, wash the weighed Chinese medicinal materials to remove the dust and impurities on the surface, and ensure the purity of the medicinal materials;

[0012] S2: Stir-frying treatment

[0013] S21: Place the weighed medicinal materials in a stainless steel frying pan, continuously heat with a small fire, control the temperature between 80-120 °C, stir-fry continuously for 20-30 minutes until the medicinal materials are half-cooked, emit a unique aroma and the color slightly darkens;

[0014] S22: After the stir-frying is completed, transfer the medicinal materials to a clean and ventilated stainless steel tray and let them cool naturally to room temperature to avoid overheating of the medicinal materials due to the residual heat;

[0015] S23: Add an appropriate amount of pure water to the cooled medicinal materials, so that the water surface is 2-3 cm higher than the surface of the medicinal materials, stir them evenly to ensure that all the medicinal materials are fully in contact with the water, then cover with plastic wrap and let stand for 8-12 hours to make the medicinal materials completely soaked through;

[0016] S3: Fermentation treatment

[0017] S31: Transfer the medicaments after temperature penetration and the soaking water together to a sterilized fermentation tank. Keep the fermentation tank at a constant temperature, with the temperature between 28 - 32 °C and the humidity between 60% - 70%. Introduce a specific probiotic flora to accelerate the fermentation process and enhance the fermentation effect. Seal the fermentation tank and start the first fermentation for 10 days.

[0018] S32: After 10 days of the first fermentation, open the fermentation tank and use sterile tools to thoroughly turn over the medicaments to ensure that the medicaments up and down, inside and outside are fully mixed, making the fermentation more uniform. During the turning-over process, check the fermentation situation of the medicaments and record the changes in color, smell, and texture.

[0019] S33: After the turning-over is completed, re-seal the fermentation tank and conduct the second fermentation for 10 days. During this period, continuously monitor the temperature and humidity inside the fermentation tank and make records.

[0020] S4: Preparation of the medicinal film

[0021] S41: After the fermentation is completed, take out the medicaments from the fermentation tank and place them in a low-temperature drying oven. Dry them at 40 - 50 °C until the water content is lower than 10%. Use an ultrafine pulverizer to pulverize the dried medicaments into fine powder with a mesh size of 100 - 200, and sieve to remove coarse particles to ensure that the powder is uniform and delicate.

[0022] S42: Mix the pulverized medicinal powder with azone and hot melt adhesive in proportion, add an appropriate amount of organic solvent, stir evenly to make a paste-like material, and at the same time add borneol and menthol to enhance the medicinal effect by using their volatility and penetrability.

[0023] S43: Use a special film-making device to evenly coat the paste-like material on medical non-woven fabric, control the thickness to be 1 mm to make the medicinal film, cut the medicinal film into appropriate sizes for standby.

[0024] S5: Preparation of the plaster patch

[0025] Assemble the prepared medicinal film with release paper and medical tape into a plaster patch, and use vacuum packaging to ensure that the plaster patch is not contaminated during storage and the medicinal effect is stable.

[0026] Preferably, in the medicinal material pretreatment stage of S1, use an ultrasonic cleaning device to clean the medicinal materials at a frequency of 40 kHz and a water temperature of 30 °C for 15 minutes.

[0027] Preferably, the specific probiotic flora in S31 is a combination of Bacillus subtilis, lactic acid bacteria, and yeast, and the inoculation ratio is 3:2:1; in the fermentation treatment stage, use a gas sensor to continuously monitor the carbon dioxide and oxygen content in the fermentation tank and automatically regulate the ventilation system.

[0028] Preferably, a dehumidifying device is equipped in the low-temperature drying oven in S41 to control the relative humidity in the oven at 20%-30%; during the mixing in S42, a planetary stirrer is used, with a stirring speed of 1000-1200 r / min and a stirring time of 30 minutes; in the film forming step of S43, the medical non-woven fabric is pre-sterilized by ultraviolet rays for 30 minutes.

[0029] Preferably, the organic solvent in S42 specifically adopts any one or more of ethanol, propylene glycol, and polyethylene glycol.

[0030] Preferably, after the plaster patch is prepared in S5, a seal integrity test is carried out, and the vacuum decay method is used for detection, with a leakage rate not exceeding 0.01 mL / s.

[0031] Preferably, before using the plaster patch prepared in S5, the plaster patch is placed in a constant temperature heater at 45°C and heated for 3-5 minutes to soften it; clean the skin of the painful and numb area, and after the skin is dry, cover the heated plaster patch on the painful and numb area, with an area exceeding twice that of the area, and gently press to ensure even sticking without bubbles and gaps; the pH value of the finished plaster patch is controlled between 6.5 and 7.5 to ensure skin compatibility.

[0032] The beneficial effects of the present invention: In the formula of the traditional Chinese medicine composite plaster, notoginseng promotes blood circulation and removes blood stasis, can effectively promote blood circulation in the damaged area, accelerate the dissipation of blood stasis, and provide nutrients for tissue repair; lycopodium clavatum, clematis chinensis, etc. can dispel wind and dampness, dredge collaterals and relieve pain, and have a significant effect on relieving pain and numbness. Many medicinal materials cooperate with each other, which can not only relieve the surface symptoms such as pain and numbness caused by sports injuries, but also deeply repair the damaged tissues, solve the problem that it is difficult for traditional treatments to completely or mostly restore the damaged area, and after the patient recovers, as long as attention is paid to maintenance, the recurrence probability is significantly reduced, providing a long-term and stable treatment effect for the patient, reducing the burden of repeated treatment. The plaster patch is heated and covered on the painful and numb area with an area exceeding twice that of the area, which can expand the scope of drug action, fully cover the damaged area, and improve the treatment effect. Gently pressing to ensure even sticking without bubbles and gaps can ensure full contact between the drug and the skin and promote absorption. Controlling the pH value of the finished plaster patch between 6.5 and 7.5, which is close to the pH value of human skin, can effectively reduce the irritation to the skin and reduce the occurrence probability of adverse reactions such as allergies, significantly improving the comfort of users during the treatment process. Detailed implementation mode

[0033] The present invention will be further described below with reference to the embodiments.

[0034] Embodiment 1

[0035] The present invention provides an embodiment: a traditional Chinese medicine compound plaster for treating pain and numbness caused by meridian blockage, comprising the following components: 10 g of Panax notoginseng, 10 g of Lycopodium clavatum, 10 g of Datura metel, 10 g of Clematis chinensis, 10 g of Ligusticum chuanxiong, 10 g of Angelica pubescens, 10 g of Angelica sinensis, 10 g of Zingiber officinale, 10 g of Salvia miltiorrhiza, 10 g of Syzygium aromaticum, 10 g of Achyranthes bidentata, 10 g of Dipsacus asperoides, 10 g of Trogopterus dung, 10 g of Carthamus tinctorius, 10 g of Ledebouriella seseloides, 10 g of Psoralea corylifolia, 10 g of Sanguis draxonis, 10 g of Corydalis yanhusuo, 10 g of Pheretima aspergillum, 10 g of Asarum sieboldii, 10 g of Olibanum, 10 g of Myrrha, 10 g of Borneol, 10 g of Menthol, 10 g of Azone, and 20 g of hot melt adhesive. The Panax notoginseng is Chun Panax notoginseng with a saponin content of not less than 6%, and is used after removing the rhizome and slicing. The Lycopodium clavatum is harvested in autumn and is reserved after being naturally dried to a water content of 12%-15%.

[0036] A preparation method of a traditional Chinese medicine compound plaster for treating pain and numbness caused by meridian blockage, which comprises a traditional Chinese medicine compound plaster for treating pain and numbness caused by meridian blockage as described above, and the steps are as follows:

[0037] S1: Pretreatment of medicinal materials

[0038] According to the formula, accurately weigh the weight of each Chinese medicinal material, wash the weighed Chinese medicinal materials to remove the dust and impurities on the surface, ensure the purity of the medicinal materials, and use an ultrasonic cleaning device to clean the medicinal materials at a frequency of 40 kHz and a water temperature of 30°C for 15 minutes;

[0039] S2: Stir-frying treatment

[0040] S21: Place the weighed medicinal materials in a stainless steel frying pan, continuously heat with a low fire, control the temperature between 80-120°C, continuously stir-fry for 20-30 minutes until the medicinal materials are semi-cooked, emit a unique aroma and the color slightly darkens;

[0041] S22: After the stir-frying is completed, transfer the medicinal materials to a clean and ventilated stainless steel tray and naturally cool to room temperature to avoid overheating of the medicinal materials due to the residual heat;

[0042] S23: Add an appropriate amount of pure water to the cooled medicinal materials, with a height of 2-3 cm above the surface of the medicinal materials being appropriate, stir evenly to ensure that all the medicinal materials are fully in contact with the water, then cover with plastic wrap and let stand for 8-12 hours to make the medicinal materials completely soaked through;

[0043] S3: Fermentation treatment

[0044] S31: Transfer the medicaments after heat penetration together with the soaking water to a sterilized fermentation tank. Keep the fermentation tank at a constant temperature, with the temperature between 28 - 32 °C and the humidity between 60% - 70%. Introduce a specific probiotic flora to accelerate the fermentation process and enhance the fermentation effect. Seal the fermentation tank and start the first fermentation for 10 days. The specific probiotic flora is a combination of Bacillus subtilis, lactic acid bacteria, and yeast, and the inoculation ratio is 3:2:1.

[0045] S32: After 10 days of the first fermentation, open the fermentation tank and use sterile tools to thoroughly turn over the medicaments to ensure that the medicaments up and down, inside and outside are fully mixed, making the fermentation more uniform. During the turning-over process, check the fermentation situation of the medicaments and record the changes in color, smell, and texture.

[0046] S33: After the turning-over is completed, re-seal the fermentation tank and conduct the second fermentation for 10 days. During this period, continuously monitor the temperature and humidity inside the fermentation tank and make records. During the fermentation treatment stage, use a gas sensor to real-time monitor the carbon dioxide and oxygen content inside the fermentation tank and automatically regulate the ventilation system.

[0047] S4: Preparation of the medicinal film

[0048] S41: After the fermentation is completed, take out the medicaments from the fermentation tank and place them in a low-temperature drying oven. Dry them at 40 - 50 °C until the water content is less than 10%. Use an ultra-fine pulverizer to pulverize the dried medicaments into fine powder with a mesh size of 100 - 200. Sieve to remove coarse particles to ensure that the powder is uniform and delicate. The low-temperature drying oven is equipped with a dehumidification device to control the relative humidity inside the oven at 20% - 30%.

[0049] S42: Mix the pulverized medicament powder with azone and hot melt adhesive in proportion, add an appropriate amount of organic solvent, and stir evenly to make a paste-like material. At the same time, add borneol and menthol to enhance the medicinal effect by utilizing their volatility and penetrability. Use a planetary stirrer with a stirring speed of 1000 - 1200 r / min and a stirring time of 30 minutes. The organic solvent specifically uses any one or more of ethanol, propylene glycol, and polyethylene glycol.

[0050] S43: Use a special film-making device to evenly coat the paste-like material on medical non-woven fabric, control the thickness to be 1 mm, make the medicinal film, cut the medicinal film into appropriate sizes, and set aside. The medical non-woven fabric has been pre-sterilized by ultraviolet light for 30 minutes.

[0051] S5: Preparation of the plaster patch

[0052] Assemble the prepared medicinal film with release paper and medical tape into a plaster patch, and use vacuum packaging to ensure that the plaster patch is not contaminated during storage and the medicinal effect is stable. After the plaster patch is prepared, conduct a seal integrity test, using the vacuum decay method for detection, and the leakage rate does not exceed 0.01 mL / s.

[0053] Before using the plaster patch prepared with S5, place the plaster patch in a constant temperature heater at 45°C and heat it for 3 - 5 minutes to soften it; clean the skin of the painful and numb area, and after the skin is dry, cover the heated plaster patch on the painful and numb area, with the area exceeding twice that of the area, gently press to ensure even sticking without air bubbles and gaps; control the pH value of the finished plaster patch between 6.5 - 7.5 to ensure skin compatibility.

[0054] Example 2

[0055] The present invention provides an example: a traditional Chinese medicine composite plaster for treating pain and numbness caused by meridian blockage, comprising the following components: 20 g of Panax notoginseng, 17 g of Lycopodium clavatum, 16 g of Datura metel, 20 g of Clematis chinensis, 15 g of Ligusticum chuanxiong, 16 g of Angelica pubescens, 20 g of Angelica sinensis, 20 g of Zingiber officinale, 20 g of Salvia miltiorrhiza, 20 g of Syzygium aromaticum, 15 g of Achyranthes bidentata, 15 g of Dipsacus asperoides, 15 g of Trogopterus dung, 15 g of Carthamus tinctorius, 15 g of Saposhnikovia divaricata, 15 g of Psoralea corylifolia, 14 g of Sanguis draxonis, 20 g of Corydalis yanhusuo, 20 g of Pheretima aspergillum, 30 g of Asarum sieboldii, 13 g of Olibanum, 15 g of Myrrha, 20 g of Borneol, 20 g of Menthol, 15 g of Azone, 25 g of hot melt adhesive. The Panax notoginseng is Chun Panax notoginseng with the saponin content not less than 6%, and after removing the rhizome and slicing, it is used. The Lycopodium clavatum is harvested in autumn and is reserved after being naturally dried to a water content of 12% - 15%.

[0056] A preparation method of a traditional Chinese medicine composite plaster for treating pain and numbness caused by meridian blockage, which comprises a traditional Chinese medicine composite plaster for treating pain and numbness caused by meridian blockage as described above, and the steps are as follows:

[0057] S1: Pretreatment of medicinal materials

[0058] According to the formula, accurately weigh the weight of each Chinese medicinal material, wash the weighed Chinese medicinal materials to remove the dust and impurities on the surface to ensure the purity of the medicinal materials, and use an ultrasonic cleaning device to clean the medicinal materials at a frequency of 40 kHz and a water temperature of 30°C for 15 minutes;

[0059] S2: Stir-frying treatment

[0060] S21: Place the weighed medicinal materials in a stainless steel frying pan, continuously heat with a small fire, control the temperature between 80 - 120°C, and continuously stir-fry for 20 - 30 minutes until the medicinal materials are semi-cooked, emitting a unique aroma and the color slightly darkens;

[0061] After the stir-frying is completed, transfer the medicinal materials to a clean and ventilated stainless steel tray and naturally cool to room temperature to avoid excessive heating of the medicinal materials due to residual heat:

[0062] S23: Add an appropriate amount of pure water to the cooled medicinal materials, preferably to cover the surface of the medicinal materials by 2-3 cm, stir it evenly to ensure that all the medicinal materials are fully exposed to water, then cover with plastic wrap and let it stand for 8-12 hours to allow the medicinal materials to be completely warmed;

[0063] S3: Fermentation

[0064] S31: The warmed medicinal materials and the soaking water are transferred to a disinfected fermentation tank. The fermentation tank is kept at a constant temperature between 28-32°C and a humidity between 60% and 70%. A specific probiotic flora is added to accelerate the fermentation process and improve the fermentation effect. The fermentation tank is sealed and the first fermentation for 10 days is started. The specific probiotic flora is a combination of Bacillus subtilis, lactic acid bacteria, and yeast, and the inoculation ratio is 3:2:1.

[0065] S32: After 10 days of the first fermentation, open the fermentation tank and use sterile tools to turn over the medicinal materials to ensure that the medicinal materials are fully mixed inside and outside to make the fermentation more uniform. During the turning process, check the fermentation of the medicinal materials and record the changes in color, smell and texture.

[0066] S33: After the transfer is completed, the fermentation tank is resealed and a second fermentation is carried out for 10 days. During this period, the temperature and humidity in the fermentation tank are continuously monitored and recorded. During the fermentation process, a gas sensor is used to monitor the carbon dioxide and oxygen content in the fermentation tank in real time, and the ventilation system is automatically controlled;

[0067] S4: Preparation of drug film

[0068] S41: After fermentation is completed, the medicinal materials are taken out from the fermentation tank, placed in a low-temperature drying oven, and dried at 40-50°C until the moisture content is less than 10%. The dried medicinal materials are crushed into 100-200 mesh fine powder using an ultrafine grinder, and coarse particles are removed by sieving to ensure that the powder is uniform and fine. The low-temperature drying oven is equipped with a dehumidification device to control the relative humidity in the oven at 20%-30%;

[0069] S42: Mix the crushed drug powder with azone and hot melt adhesive in proportion, add an appropriate amount of organic solvent, stir evenly to make a paste-like material, and add borneol and menthol to improve the efficacy by utilizing their volatility and penetrability. Use a planetary mixer with a stirring speed of 1000-1200 r / min for 30 minutes. The organic solvent is specifically any one or more of ethanol, propylene glycol and polyethylene glycol.

[0070] S43: Use a dedicated film-making device to evenly apply the paste material on the medical non-woven fabric, control the thickness to 1 mm, and make a film. Cut the film into appropriate sizes for standby use. The medical non-woven fabric is sterilized with ultraviolet light for 30 minutes in advance.

[0071] S5: Preparation of Plaster

[0072] Assemble the prepared medicinal film, anti-sticking paper, and medical tape into a plaster. Use vacuum packaging to ensure that the plaster is not contaminated during storage and its medicinal efficacy is stable. After the plaster is prepared, conduct a seal integrity test. Use the vacuum decay method for testing, and the leakage rate should not exceed 0.01 mL / s.

[0073] Before using the plaster prepared by S5, place the plaster in a constant temperature heater at 45°C and heat it for 3 - 5 minutes to soften it; clean the skin of the painful and numb area. After the skin is dry, cover the heated plaster on the painful and numb area, with the area exceeding twice that of the area, and gently press to ensure even sticking without air bubbles and gaps; the pH value of the finished plaster is controlled between 6.5 - 7.5 to ensure skin compatibility.

[0074] Example 3

[0075] The present invention provides an example: a traditional Chinese medicine compound plaster for treating meridian blockage type pain and numbness, comprising the following components: 30 g of Panax notoginseng, 30 g of Lycopodium clavatum, 25 g of Datura metel, 30 g of Clematis chinensis, 20 g of Ligusticum chuanxiong, 25 g of Angelica pubescens, 30 g of Angelica sinensis, 30 g of Zingiber officinale, 30 g of Salvia miltiorrhiza, 30 g of Syzygium aromaticum, 20 g of Achyranthes bidentata, 20 g of Dipsacus asperoides, 25 g of Trogopterus dung, 25 g of Carthamus tinctorius, 25 g of Saposhnikovia divaricata, 30 g of Psoralea corylifolia, 25 g of Sanguis draxonis, 30 g of Corydalis yanhusuo, 30 g of Pheretima aspergillum, 30 g of Asarum sieboldii, 25 g of Olibanum, 20 g of Myrrha, 30 g of Borneol, 30 g of Menthol, 20 g of Azone, 30 g of hot melt adhesive. The Panax notoginseng is spring Panax notoginseng, with the saponin content not less than 6%. After removing the rhizome and slicing, it is used. The Lycopodium clavatum is harvested in autumn and is reserved after being naturally dried to a water content of 12% - 15%.

[0076] A preparation method of a traditional Chinese medicine compound plaster for treating meridian blockage type pain and numbness, which includes a traditional Chinese medicine compound plaster for treating meridian blockage type pain and numbness as described above, and the steps are as follows:

[0077] S1: Pretreatment of Medicinal Materials

[0078] According to the formula, accurately weigh the weight of each Chinese medicinal material. Wash the weighed Chinese medicinal materials to remove the dust and impurities on the surface to ensure the purity of the medicinal materials. Use an ultrasonic cleaning device to clean the medicinal materials at a frequency of 40 kHz and a water temperature of 30°C for 15 minutes;

[0079] S2: Stir-frying Treatment

[0080] S21: Place the weighed medicinal materials in a stainless steel frying pan and continuously heat with a low fire, with the temperature controlled between 80 - 120°C, and continuously stir-fry for 20 - 30 minutes until the medicinal materials are semi-cooked, emitting a unique aroma and the color slightly darkens;

[0081] S22: After frying is completed, transfer the medicinal materials to a clean and ventilated stainless-steel tray and let them cool naturally to room temperature to avoid overheating of the medicinal materials due to residual heat.

[0082] S23: Add an appropriate amount of pure water to the cooled medicinal materials, with the water level being 2 - 3 cm above the surface of the medicinal materials. Stir them evenly to ensure that all the medicinal materials are fully in contact with the water. Then cover with plastic wrap and let stand for 8 - 12 hours to allow the medicinal materials to be completely soaked through.

[0083] S3: Fermentation treatment

[0084] S31: Transfer the soaked-through medicinal materials along with the soaking water to a sterilized fermentation tank. Keep the fermentation tank at a constant temperature, with the temperature between 28 - 32 °C and the humidity between 60% - 70%. Introduce a specific probiotic flora to accelerate the fermentation process and improve the fermentation effect. Seal the fermentation tank and start the first fermentation for 10 days. The specific probiotic flora is a combination of Bacillus subtilis, lactic acid bacteria, and yeast, and the inoculation ratio is 3:2:1.

[0085] S32: After 10 days of the first fermentation, open the fermentation tank and use sterile tools to thoroughly turn over the medicinal materials to ensure full mixing of the upper and lower, inner and outer medicinal materials, making the fermentation more uniform. During the turning-over process, check the fermentation situation of the medicinal materials and record the changes in color, smell, and texture.

[0086] S33: After turning over is completed, reseal the fermentation tank and conduct the second fermentation for 10 days. Continuously monitor the temperature and humidity inside the fermentation tank during this period and make records. During the fermentation treatment stage, use a gas sensor to continuously monitor the carbon dioxide and oxygen content inside the fermentation tank and automatically regulate the ventilation system.

[0087] S4: Preparation of the medicinal film

[0088] S41: After fermentation is completed, take out the medicinal materials from the fermentation tank and place them in a low-temperature drying oven. Dry them at 40 - 50 °C until the water content is less than 10%. Use an ultrafine pulverizer to pulverize the dried medicinal materials into fine powder with a mesh size of 100 - 200. Sieve to remove coarse particles to ensure the powder is uniform and delicate. The low-temperature drying oven is equipped with a dehumidification device to control the relative humidity inside the oven at 20% - 30%.

[0089] S42: Mix the pulverized medicinal powder with azone and hot melt adhesive in proportion, add an appropriate amount of organic solvent, and stir evenly to make a paste-like material. At the same time, add borneol and menthol to enhance the medicinal effect by utilizing their volatility and penetrability. Use a planetary stirrer with a stirring speed of 1000 - 1200 r / min and a stirring time of 30 minutes. The organic solvent specifically uses any one or more of ethanol, propylene glycol, and polyethylene glycol.

[0090] S43: Use a dedicated film-making device to evenly coat the paste-like material on medical non-woven fabric, control the thickness to be 1 mm, make a medicated film, cut the medicated film into appropriate sizes, and set aside. The medical non-woven fabric has been pre-sterilized by ultraviolet rays for 30 minutes;

[0091] S5: Preparation of the plaster patch

[0092] Assemble the prepared medicated film with the release paper and medical tape into a plaster patch, and use vacuum packaging to ensure that the plaster patch is not contaminated during storage and the drug efficacy is stable. After the plaster patch is prepared, conduct a seal integrity test. Use the vacuum decay method for testing, and the leakage rate does not exceed 0.01 mL / s.

[0093] Before using the plaster patch prepared in S5, put the plaster patch into a constant-temperature heater at 45°C and heat it for 3 - 5 minutes to soften it; clean the skin of the painful and numb area, and after the skin is dry, cover the heated plaster patch on the painful and numb area, with the area exceeding twice that of the area, and gently press to ensure even sticking without air bubbles and gaps; the pH value of the finished plaster patch is controlled between 6.5 - 7.5 to ensure skin compatibility.

[0094] Experimental examples

[0095] Invite 100 patients who meet the diagnostic criteria for meridian blockage type pain and numbness. Divide the products of Example 1, 2, 3 and the traditional Chinese medicine compound plaster as Example 4 into four groups. Then evenly distribute the 100 patients into Examples 1 - 4 according to age, gender, and the severity of the condition. According to the instructions or doctor's advice, apply the plaster patch to the painful or numb area of the patients, change it regularly, record the treatment time and frequency, and collect the efficacy index data of the patients at 1 week, 2 weeks, and 4 weeks before and after the treatment respectively. Conduct statistical analysis on the collected data, and the data analysis results are as follows;

[0096]

[0097]

Claims

1. A Chinese medicinal composite plaster for treating meridian blockage type pain and numbness, characterized in that: The composition includes the following components: 10-30g of Panax notoginseng, 10-25g of Lycopodiella ciliata, 10-25g of Datura stramonium, 10-30g of Clematis, 10-20g of Ligusticum chuanxiong, 10-25g of Angelica dahurica, 10-30g of Ginger, 10-30g of Salvia miltiorrhiza, 10-30g of Clove, 10-20g of Achyranthes bidentata, 10-20g of Dipsacus asper, 10-20g of Pentaxylospermum officinale. 25g, safflower 10-25g, ventilate 10-25g, psoralea corylifolia 10-30g, blood clotting 10-25g, Corydalis 10-30g, earthworm 10-30g, asarum 10-30g, frankincense 10-25g, myrrh 10-20g, borneol 10-30g, menthol 10-30g, azone 10-20g, hot melt adhesive 20-30g.

2. The Chinese medicinal composite plaster for treating meridian blockage type pain and numbness according to claim 1, characterized in that: Specifically, the Panax notoginseng used is the spring Panax notoginseng with a saponin content of not less than 6%.

3. The Chinese medicinal composite plaster for treating meridian blockage type pain and numbness according to claim 1, characterized in that: The spatholobi is specifically prepared by natural drying, and the moisture content of the spatholobi is between 12% and 15%.

4. A method for preparing a Chinese medicinal composite plaster for treating meridian blockage type pain and numbness, characterized in that The method comprises the Chinese medicinal composite plaster for treating meridian blockage type pain and numbness according to claims 1-3, wherein the steps are as follows: S1: Pretreatment of medicinal materials According to the formula, accurately weigh each Chinese herbal medicine, wash the weighed Chinese herbal medicine, remove dust and impurities on the surface, and ensure the purity of the herbal medicine; S2: Stir-frying S21: Place the weighed herbs in a stainless steel frying pan, heat over low heat continuously, control the temperature between 80-120°C, and stir-fry for 20-30 minutes until the herbs are half cooked, emit a unique aroma, and become slightly darker in color; S22: After frying, transfer the herbs to a clean, ventilated stainless steel tray and let them cool naturally to room temperature to avoid overheating due to residual heat: S23: Add an appropriate amount of pure water to the cooled medicinal materials, preferably to cover the surface of the medicinal materials by 2-3 cm, stir it evenly to ensure that all the medicinal materials are fully exposed to water, then cover with plastic wrap and let it stand for 8-12 hours to allow the medicinal materials to be completely warmed; S3: Fermentation S31: The warmed medicinal materials and the soaking water are transferred to a disinfected fermentation tank. The fermentation tank is kept at a constant temperature between 28-32°C and a humidity between 60% and 70%. A specific probiotic flora is introduced to accelerate the fermentation process and improve the fermentation effect. The fermentation tank is sealed to start the first fermentation for 10 days. S32: After 10 days of the first fermentation, open the fermentation tank and use sterile tools to turn over the medicinal materials to ensure that the medicinal materials are fully mixed inside and outside to make the fermentation more uniform. During the turning process, check the fermentation of the medicinal materials and record the changes in color, smell and texture. S33: After the transfer is completed, the fermentation tank is resealed and a second fermentation is carried out for 10 days, during which the temperature and humidity in the fermentation tank are continuously monitored and recorded; S4: Preparation of drug film S41: After fermentation is completed, the medicinal materials are taken out from the fermentation tank, placed in a low-temperature drying oven, and dried at 40-50°C until the moisture content is less than 10%. The dried medicinal materials are crushed into fine powder of 100-200 mesh using an ultra-fine grinder, and coarse particles are removed by sieving to ensure that the powder is uniform and fine; S42: Mix the crushed drug powder with azone and hot melt adhesive in proportion, add an appropriate amount of organic solvent, stir evenly to make a paste-like material, and add borneol and menthol to improve the efficacy by utilizing their volatility and penetrability; S43: using a dedicated film-making device, evenly coating the paste material on the medical non-woven fabric, controlling the thickness to be 1 mm, making a drug film, and cutting the drug film into suitable sizes for standby use; S5: Preparation of plaster The prepared drug film is assembled into a plaster with anti-sticking paper and medical tape, and vacuum-packed to ensure that the plaster is not contaminated during storage and the efficacy is stable.

5. The method for preparing the Chinese medicinal composite plaster for treating meridian blockage type pain and numbness according to claim 4, characterized in that: During the medicinal material pretreatment stage of S1, ultrasonic cleaning equipment was used to clean the medicinal materials at a frequency of 40 kHz and a water temperature of 30 °C for 15 minutes.

6. The method for preparing the Chinese medicinal composite plaster for treating meridian blockage type pain and numbness according to claim 4, characterized in that: The specific probiotic flora in S31 is a combination of Bacillus subtilis, lactic acid bacteria, and yeast, with an inoculation ratio of 3:2:1; during the fermentation process, gas sensors are used to monitor the carbon dioxide and oxygen content in the fermentation tank in real time, and automatically adjust the ventilation system.

7. The method for preparing the Chinese medicinal composite plaster for treating meridian blockage type pain and numbness according to claim 4, characterized in that: The S41 medium and low temperature drying box is equipped with a dehumidification device to control the relative humidity in the box at 20%-30%; during mixing and blending in S42, a planetary mixer is used with a stirring speed of 1000-1200r / min and a stirring time of 30 minutes; in the S43 film forming process, the medical non-woven fabric is pre-sterilized with ultraviolet light for 30 minutes.

8. The method for preparing the Chinese medicinal composite plaster for treating meridian blockage type pain and numbness according to claim 4, characterized in that: The organic solvent in S42 is specifically any one or more of ethanol, propylene glycol and polyethylene glycol.

9. The method for preparing the Chinese medicinal composite plaster for treating meridian blockage type pain and numbness according to claim 4, characterized in that: After the S5 patch was prepared, the sealing integrity was tested using the vacuum decay method, and the leakage rate did not exceed 0.01 mL / s.

10. The method for preparing the Chinese medicinal composite plaster for treating meridian blockage type pain and numbness according to claim 4, characterized in that: Before using the plaster prepared by S5, heat the plaster in a constant temperature heater at 45°C for 3-5 minutes to soften it; clean the skin of the painful and numb area, and after the skin is dry, cover the heated plaster on the painful and numb area with an area more than twice the area, press gently to ensure that it is evenly applied without bubbles and gaps; the pH value of the finished plaster is controlled between 6.5-7.5 to ensure skin compatibility.

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