Traditional Chinese medicine composition for preventing and treating diabetes as well as application and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating diabetes as well as application and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of three-year-old whole Zhejiang radix ophiopogonis, 3-6 parts of five-year-old ginseng and 3-6 parts of smoked plum, and 3-15 parts of lily and 3-6 parts of rhizoma phragmitis are added according to the type of diabetes mellitus or according to the type of the diabetes mellitus; or adding 3-6 parts of emblic leafflower fruit, 3-6 parts of orange peel and 6-20 parts of lotus seed into the middle warmer; or 3-6 parts of pulp of dogwood fruit and 3-6 parts of cistanche deserticola are added for lower digestion. The food is suitable for various diabetes mellitus, is reasonable in raw material design, and has the effects of nourishing yin, tonifying qi, tonifying spleen, benefiting lung, engendering liquid, quenching thirst and the like. The traditional Chinese medicine composition provided by the invention adopts a pure traditional Chinese medicine formula, avoids side effects of western medicine treatment, is high in safety, and can effectively reduce the blood sugar level.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for preventing and treating diabetes, its application and preparation method. Background Art

[0002] At present, diabetes is mainly treated with drugs, mainly by regulating blood sugar levels to control symptoms, but it cannot fundamentally improve islet function or repair insulin resistance. Traditional Chinese medicine treatment focuses on conditioning the whole body of the human body, and through the action modes of multiple components, multiple targets and multiple pathways, comprehensively regulates the body functions, and can effectively improve symptoms and stabilize blood sugar.

[0003] Therefore, how to develop a traditional Chinese medicine composition that can fundamentally reduce blood sugar levels, its application and preparation method is a technical problem that needs to be solved urgently by those skilled in the art. Summary of the Invention

[0004] In view of this, the present invention provides a traditional Chinese medicine composition for preventing and treating diabetes, its application and preparation method.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A traditional Chinese medicine composition for preventing and treating diabetes, the traditional Chinese medicine composition for treating upper consumption type diabetes comprises the following raw materials in parts by weight: 10-20 parts of three-year-old whole plant of Zhejiang Ophiopogon japonicus, 3-6 parts of five-year-old ginseng, 3-6 parts of smoked plum, 3-15 parts of lily, 3-6 parts of reed rhizome;

[0007] Or, the traditional Chinese medicine composition for treating middle consumption type diabetes comprises the following raw materials in parts by weight: 10-20 parts of three-year-old whole plant of Zhejiang Ophiopogon japonicus, 3-6 parts of five-year-old ginseng, 3-6 parts of smoked plum, 3-6 parts of Phyllanthus emblica, 3-6 parts of tangerine peel, 6-20 parts of lotus seed;

[0008] Or, the traditional Chinese medicine composition for treating lower consumption type diabetes comprises the following raw materials in parts by weight: 10-20 parts of three-year-old whole plant of Zhejiang Ophiopogon japonicus, 3-6 parts of five-year-old ginseng, 3-6 parts of smoked plum, 3-6 parts of cornel, 3-6 parts of cistanche.

[0009] The three-year-old whole plant of Zhejiang Ophiopogon japonicus refers to Zhejiang Ophiopogon japonicus planted for three years, and the leaves above the ground and the rhizome, tuberous roots, rootlets, etc. below the ground are mixed for medicinal use.

[0010] Advantages of the present invention: The present invention is applicable to various types of diabetes. The raw materials are rationally designed and have the effects of nourishing yin and replenishing qi, invigorating the spleen and benefiting the lung, promoting the production of body fluids and quenching thirst, etc. The combination of traditional Chinese medicine formulas provided by the present invention uses pure traditional Chinese medicine formulas, avoiding the side effects of western medicine treatment and having high safety; it can effectively reduce blood sugar levels and relieve symptoms such as thirst, frequent urination, strong appetite, and weight loss in diabetic patients; by regulating the functions of the zang-fu organs and improving the physical conditions of qi-yin deficiency and insufficient body fluids, it achieves the effect of treating both the symptoms and the root cause; it is convenient to take, and patients have high compliance, which helps to improve the treatment effect.

[0011] The whole plant of three-year-old Zhejiang Ophiopogon japonicus (leaves, tuberous roots, fibrous roots and rhizomes) tastes sweet and is slightly cold in nature, enters the heart, lung and stomach meridians, and has the effects of nourishing yin and promoting the production of body fluids, moistening the lungs and clearing the heart, thirst due to fluid impairment, internal heat diabetes, restlessness and insomnia; Ginseng tastes sweet and is slightly warm in nature, enters the spleen, lung, heart and kidney meridians, and has the effects of greatly replenishing vital energy, invigorating the spleen and benefiting the lung, promoting the production of body fluids and nourishing blood, internal heat diabetes, qi and blood deficiency; Dark Plum tastes sour, astringent and is neutral in nature, enters the lung, spleen and heart meridians, and has the effects of astringing the lung and promoting the production of body fluids, internal heat diabetes; Lily tastes sweet and is slightly cold in nature, enters the heart and lung meridians, and has the effects of nourishing yin and promoting the production of body fluids, moistening the lungs and relieving cough, clearing the heart and calming the mind; Reed Rhizome tastes sweet and is cold in nature, enters the lung and stomach meridians, and has the effects of clearing heat and purging fire, promoting the production of body fluids and quenching thirst; Phyllanthus emblica tastes sweet, sour, astringent and cool, enters the lung and stomach meridians, and has the effects of clearing heat and cooling blood, strengthening the stomach and promoting the production of body fluids; Tangerine Peel tastes bitter, pungent and warm, enters the lung and spleen meridians, and has the effects of strengthening the spleen and regulating qi, drying dampness and resolving phlegm; Lotus Seed tastes sweet, astringent and is flat in nature, enters the spleen, kidney and heart meridians, and has the effects of invigorating the spleen and tonifying the kidney, astringing sperm, nourishing the heart and calming the mind; Fruit of Medicinal Cornal tastes sour, astringent and slightly warm, enters the liver and kidney meridians, and has the effects of tonifying the liver and kidney, astringing and securing the collapse, soreness of the waist and knees, profuse sweating and collapse, frequent urination, internal heat diabetes; Cistanche deserticola tastes sweet, salty and warm, and has the effects of warming yang and tonifying the kidney, benefiting essence and blood, and moistening the intestines and relieving constipation.

[0012] The whole plant of three-year-old Zhejiang Ophiopogon japonicus is the monarch drug, five-year-old Ginseng and Dark Plum are the ministerial drugs, and Lily, Reed Rhizome, Phyllanthus emblica, Tangerine Peel, Lotus Seed, Fruit of Medicinal Cornal and Cistanche deserticola are the assistant and guiding drugs.

[0013] Three-year-old whole plant of Ophiopogon japonicus, Panax ginseng, Prunus mume, Lilium brownii, Phragmites communis root, Phyllanthus emblica, Citrus reticulata peel, Nelumbo nucifera seed, Cornus officinalis, Cistanche deserticola, etc. have the effects of moistening the lungs, tonifying the spleen, tonifying the kidneys, nourishing yin and promoting fluid production, and clearing internal heat and relieving thirst. However, ① The three-year-old whole plant of Ophiopogon japonicus is sweet in taste and slightly cold in nature, and is partial to clearing deficiency heat and relieving thirst, and nourishing yin and promoting fluid production. It is aimed at the main symptoms of diabetes, yin deficiency with internal heat and insufficient body fluids; ② Panax ginseng is sweet, slightly bitter, and slightly warm in nature, and is partial to greatly tonifying primordial qi, tonifying the spleen and benefiting the lungs, promoting fluid production and replenishing fluids. Panax ginseng greatly tonifies primordial qi, that is, it can supplement and enhance the functions of the five zang-organs and six fu-organs. Especially the spleen-tonifying and lung-benefiting functions of Panax ginseng. The lung governs qi, and the spleen is responsible for transporting and transforming water and grains, playing the function of the middle jiao and stimulating the secretion of insulin. The function of promoting fluid production and replenishing fluids (qi and blood have the same origin) of Panax ginseng is also the supplement for the consumption of the substances of the function of greatly tonifying primordial qi. Therefore, it can improve the digestion and absorption of the active ingredients of Ophiopogon japonicus and Prunus mume in the body and enhance the body's disease resistance; ③ Prunus mume is sour in taste and can enhance the function of promoting fluid production and quenching thirst of Ophiopogon japonicus and Panax ginseng in the formula; ④ The three-year-old whole plant of Ophiopogon japonicus is slightly cold in nature and can balance the heatiness of Panax ginseng. However, the warmth of Panax ginseng can prevent the coldness of the three-year-old whole plant of Ophiopogon japonicus from damaging the spleen and stomach and does not affect digestion and absorption, enabling the formula to play a more effective role; ⑤ For the upper consumption type, the disease (syndrome) is in the upper jiao, and the core is in the lungs. Assisting with Lilium brownii and Phragmites communis root to moisten the lungs and quench thirst, nourish yin and promote fluid production, and enhance lung function; ⑥ For the middle consumption type, the disease (syndrome) is in the middle jiao, and the key is in the spleen and stomach. Assisting with Nelumbo nucifera seed, Citrus reticulata peel, Phyllanthus emblica, etc. to strengthen the spleen and stomach, strengthen the middle jiao, play the role of transporting and transforming water and grains essence, increase nutrient absorption (generate qi and blood), improve the overall visceral function, gradually restore insulin function, and exert the function of insulin; ⑦ For the lower consumption type, the disease (syndrome) is in the lower jiao, and the focus is on the kidneys. The kidneys store (reserve) essence (essence and blood), that is, the body's nutrients are firmly held; the kidneys govern water (water belongs to yin and is easy to damage yang qi), that is, the kidneys have the function of regulating the body's water metabolism. Assisting with Cornus officinalis mainly has the effects of tonifying the liver and kidneys, astringing and securing (preventing kidney essence deficiency), treating frequent urination (polyuria), and clearing internal heat and relieving thirst; Assisting with Cistanche deserticola mainly tonifies kidney qi (yang) and nourishes essence and blood, with both yin and yang tonifying. It can both tonify kidney qi (play the functional role of the kidneys storing essence and governing water) and nourish essence and blood. Under the combined action of Cornus officinalis and Cistanche deserticola, kidney function is enhanced, the functions of the kidneys storing essence and governing water are improved, achieving the effects of differentiating (absorbing and storing effective nutrient components) and separating turbidity (removing dregs), and controlling or reducing blood sugar levels.

[0014] Furthermore, the traditional Chinese medicine composition for treating upper consumption type diabetes comprises raw materials in the following parts by weight: 10 parts of three-year-old whole plant of Ophiopogon japonicus, 3 parts of five-year-old Panax ginseng, 3 parts of Prunus mume, 3 parts of Lilium brownii, 3 parts of Phragmites communis root;

[0015] Or, the traditional Chinese medicine composition for treating middle consumption type diabetes comprises raw materials in the following parts by weight: 10 parts of three-year-old whole plant of Ophiopogon japonicus, 3 parts of five-year-old Panax ginseng, 3 parts of Prunus mume, 3 parts of Phyllanthus emblica, 3 parts of Citrus reticulata peel, 6 parts of Nelumbo nucifera seed;

[0016] Or, the traditional Chinese medicine composition for treating lower consumption type diabetes comprises raw materials in the following parts by weight: 10 parts of three-year-old whole plant of Ophiopogon japonicus, 3 parts of five-year-old Panax ginseng, 3 parts of Prunus mume, 6 parts of Cornus officinalis, 6 parts of Cistanche deserticola.

[0017] Furthermore, the traditional Chinese medicine composition for treating upper-jiao diabetes mellitus comprises the following raw materials in parts by weight: 15 parts of whole Zhejiang Ophiopogon japonicus plants of three years old, 5 parts of ginseng plants of five years old, 5 parts of smoked plums, 9 parts of lilies, and 5 parts of reed rhizomes;

[0018] Or, the traditional Chinese medicine composition for treating middle-jiao diabetes mellitus comprises the following raw materials in parts by weight: 15 parts of whole Zhejiang Ophiopogon japonicus plants of three years old, 5 parts of ginseng plants of five years old, 5 parts of smoked plums, 5 parts of Phyllanthus emblica, 5 parts of tangerine peels, and 12 parts of lotus seeds;

[0019] Or, the traditional Chinese medicine composition for treating lower-jiao diabetes mellitus comprises the following raw materials in parts by weight: 15 parts of whole Zhejiang Ophiopogon japonicus plants of three years old, 5 parts of ginseng plants of five years old, 5 parts of smoked plums, 4 parts of cornel fruits, and 4 parts of cistanches.

[0020] Furthermore, the traditional Chinese medicine composition for treating upper-jiao diabetes mellitus comprises the following raw materials in parts by weight: 20 parts of whole Zhejiang Ophiopogon japonicus plants of three years old, 6 parts of ginseng plants of five years old, 6 parts of smoked plums, 15 parts of lilies, and 6 parts of reed rhizomes;

[0021] Or, the traditional Chinese medicine composition for treating middle-jiao diabetes mellitus comprises the following raw materials in parts by weight: 20 parts of whole Zhejiang Ophiopogon japonicus plants of three years old, 6 parts of ginseng plants of five years old, 6 parts of smoked plums, 6 parts of Phyllanthus emblica, 6 parts of tangerine peels, and 20 parts of lotus seeds;

[0022] Or, the traditional Chinese medicine composition for treating lower-jiao diabetes mellitus comprises the following raw materials in parts by weight: 20 parts of whole Zhejiang Ophiopogon japonicus plants of three years old, 3 parts of ginseng plants of five years old, 6 parts of smoked plums, 3 parts of cornel fruits, and 3 parts of cistanches.

[0023] The present invention also provides an application of the above traditional Chinese medicine composition in the preparation of a traditional Chinese medicine composition preparation for preventing and treating diabetes mellitus.

[0024] The present invention also provides a preparation method of a traditional Chinese medicine composition preparation for preventing and treating diabetes mellitus, comprising the following steps:

[0025] (1) Weigh each raw material according to the weight parts of the above traditional Chinese medicine composition;

[0026] (2) Make the traditional Chinese medicine composition into teabags, mixtures, granules, tablets or pills.

[0027] The beneficial effects of the present invention: simple preparation, convenient administration, suitable for industrial production, and having great application value.

[0028] Furthermore, the preparation method of the above traditional Chinese medicine composition preparation for preventing and treating diabetes mellitus comprises the following steps:

[0029] ① Weigh each raw material according to the weight parts of the above traditional Chinese medicine composition;

[0030] ② Wash the three-year-old whole Zhejiang Ophiopogon japonicus plants clean, cut them into segments 2.0 cm long or slices 0.5 cm thick, and dry them in the sun or by baking until the water content is 13% for later use;

[0031] ③ Crush the three-year-old whole Zhejiang Ophiopogon japonicus segments or slices, five-year-old ginseng, smoked plum, lily, phragmites rhizome, phyllanthus emblica, tangerine peel, and lotus seeds, and sieve them through a 60-mesh sieve for later use;

[0032] ④ Store the fructus corni and cistanche deserticola at -15°C for 48 hours, then crush them and sieve them through a 60-mesh sieve for later use;

[0033] ⑤ Mix the powders obtained in steps ③ and ④ evenly for later use;

[0034] ⑥ Weigh 10 - 15 grams per bag of the mixed powder obtained in step ⑤ and package it into teabags.

[0035] Further, the preparation method of the above traditional Chinese medicine composition preparation for preventing and treating diabetes includes the following steps:

[0036] (A) Weigh each raw material according to the weight parts of the above traditional Chinese medicine composition;

[0037] (B) Wash the three-year-old whole Zhejiang Ophiopogon japonicus plants clean, cut them into segments 2.0 cm long or slices 0.5 cm thick, and dry them in the sun or by baking until the water content is 13% for later use;

[0038] (C) Prepare the three-year-old whole Zhejiang Ophiopogon japonicus segments or slices, smoked plum, lily, phragmites rhizome, phyllanthus emblica, tangerine peel, lotus seeds, cistanche deserticola, and fructus corni into a water extract by conventional methods. After crushing ginseng into powder, mix it with the water extract and make it into granules, tablets or pills by conventional methods.

[0039] Further, the preparation method of the above traditional Chinese medicine composition preparation for preventing and treating diabetes includes the following steps:

[0040] (a) Weigh each raw material according to the weight parts of the above traditional Chinese medicine composition;

[0041] (b) Wash the three-year-old whole Zhejiang Ophiopogon japonicus plants clean, cut them into segments 2.0 cm long or slices 0.5 cm thick, and dry them in the sun or by baking until the water content is 13% for later use;

[0042] (c) Prepare the three-year-old whole Zhejiang Ophiopogon japonicus segments or slices, smoked plum, lily, phragmites rhizome, phyllanthus emblica, tangerine peel, lotus seeds, cistanche deserticola, and fructus corni into a water extract by conventional methods. After crushing ginseng into coarse powder, prepare it into an ethanol extract by conventional methods. Combine the obtained water extract and ethanol extract and prepare it into a mixture by conventional methods. Specific embodiments

[0043] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Apparently, the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0044] Example 1

[0045] A preparation method of a traditional Chinese medicine composition preparation for preventing and treating upper consumption type diabetes mellitus includes the following steps:

[0046] (A) Weigh 150 grams of three-year-old whole plant of Ophiopogon japonicus, 50 grams of five-year-old ginseng, 50 grams of smoked plum, 90 grams of lily, and 50 grams of reed rhizome;

[0047] (B) Wash the three-year-old whole plant of Ophiopogon japonicus clean, cut it into sections with a length of 2.0 cm, and dry it in the sun until the water content is 13% for standby;

[0048] (C) Mix the sections of the three-year-old whole plant of Ophiopogon japonicus, smoked plum, lily, and reed rhizome, decoct with water twice. For the first time, add 10 times the amount of water and decoct for 2 hours at a decocting temperature of 100 °C, filter, add 10 times the amount of water to the filter residue and decoct for 1.5 hours at a decocting temperature of 100 °C, filter, and combine the two filtrates for standby to obtain a water extract;

[0049] (D) Crush the five-year-old ginseng through an 80-mesh sieve, mix it with the water extract, granulate through a 14-mesh sieve, dry at 60 °C for 60 min, and press tablets at 40 kN to make tablets with a weight of 1.0 g / tablet.

[0050] Example 2

[0051] A preparation method of a traditional Chinese medicine composition preparation for preventing and treating upper consumption type diabetes mellitus includes the following steps:

[0052] (A) Weigh 100 grams of three-year-old whole plant of Ophiopogon japonicus, 30 grams of five-year-old ginseng, 30 grams of smoked plum, 30 grams of lily, and 30 grams of reed rhizome;

[0053] Steps (B)-(D) are the same as those in Example 1.

[0054] Example 3

[0055] A preparation method of a traditional Chinese medicine composition preparation for preventing and treating upper consumption type diabetes mellitus includes the following steps:

[0056] (A) Weigh 200 grams of three-year-old whole plant of Ophiopogon japonicus, 60 grams of five-year-old ginseng, 60 grams of smoked plum, 150 grams of lily, and 60 grams of reed rhizome;

[0057] Steps (B)-(D) are the same as those in Example 1.

[0058] Example 4

[0059] Preparation method of traditional Chinese medicine composition preparation for preventing and treating middle-consumption type diabetes mellitus, comprising the following steps:

[0060] (A) Weigh 150 grams of three-year-old whole plant of Ophiopogon japonicus, 50 grams of five-year-old ginseng, 50 grams of Chinese smoked plum, 50 grams of Phyllanthus emblica, 50 grams of tangerine peel, and 120 grams of lotus seed;

[0061] (B) Wash the three-year-old whole plant of Ophiopogon japonicus clean, cut it into sections with a length of 2.0 cm, and dry it in the sun until the water content is 13% for standby;

[0062] (C) Mix the sections of three-year-old whole plant of Ophiopogon japonicus, Chinese smoked plum, Phyllanthus emblica, tangerine peel and lotus seed, decoct with water twice. For the first time, add 10 times the amount of water and decoct for 2 hours at a decocting temperature of 100 °C, filter, add 10 times the amount of water to the filter residue and decoct for 1.5 hours at a decocting temperature of 100 °C, filter, and combine the two filtrates for standby to obtain a water extract;

[0063] (D) Crush the five-year-old ginseng through an 80-mesh sieve, mix it with the water extract, granulate through a 14-mesh sieve, dry at 60 °C for 60 min, and press tablets, controlling the tablet hardness to be 40 N to make tablets with a weight of 1.0 g / tablet.

[0064] Example 5

[0065] Preparation method of traditional Chinese medicine composition preparation for preventing and treating middle-consumption type diabetes mellitus, comprising the following steps:

[0066] (A) Weigh 100 grams of three-year-old whole plant of Ophiopogon japonicus, 30 grams of five-year-old ginseng, 30 grams of Chinese smoked plum, 30 grams of Phyllanthus emblica, 30 grams of tangerine peel, and 60 grams of lotus seed;

[0067] Steps (B)-(D) are the same as those in Example 4.

[0068] Example 6

[0069] Preparation method of traditional Chinese medicine composition preparation for preventing and treating middle-consumption type diabetes mellitus, comprising the following steps:

[0070] (A) Weigh 200 grams of three-year-old whole plant of Ophiopogon japonicus, 60 grams of five-year-old ginseng, 60 grams of Chinese smoked plum, 60 grams of Phyllanthus emblica, 60 grams of tangerine peel, and 200 grams of lotus seed;

[0071] Steps (B)-(D) are the same as those in Example 4.

[0072] Example 7

[0073] Preparation method of traditional Chinese medicine composition preparation for preventing and treating lower-consumption type diabetes mellitus, comprising the following steps:

[0074] (A) Weigh 150 grams of three-year-old whole Zhejiang Ophiopogon japonicus, 50 grams of five-year-old ginseng, 50 grams of smoked plum, 40 grams of cornel, and 40 grams of cistanche;

[0075] (B) Wash the three-year-old whole Zhejiang Ophiopogon japonicus clean, cut it into sections with a length of 2.0 cm, and dry it in the sun until the water content is 13% for later use;

[0076] (C) Mix the sections of three-year-old whole Zhejiang Ophiopogon japonicus, smoked plum, cornel, and cistanche, decoct them with water twice. For the first time, add 10 times the amount of water and decoct for 2 hours at a decocting temperature of 100 °C, filter, add 10 times the amount of water to the filter residue and decoct for 1.5 hours at a decocting temperature of 100 °C, filter, and combine the two filtrates for later use to obtain a water extract;

[0077] (D) Crush the five-year-old ginseng through an 80-mesh sieve, mix it with the water extract, granulate through an 18-mesh sieve, dry at 70 °C for 100 min, and press tablets, controlling the tablet hardness to be 20 N to make tablets with a weight of 1.0 g / tablet.

[0078] Example 8

[0079] A preparation method of a traditional Chinese medicine composition preparation for preventing and treating lower-consumption type diabetes mellitus, comprising the following steps:

[0080] (A) Weigh 100 grams of three-year-old whole Zhejiang Ophiopogon japonicus, 30 grams of five-year-old ginseng, 30 grams of smoked plum, 60 grams of cornel, and 60 grams of cistanche;

[0081] Steps (B)-(D) are the same as those in Example 7.

[0082] Example 9

[0083] A preparation method of a traditional Chinese medicine composition preparation for preventing and treating lower-consumption type diabetes mellitus, comprising the following steps:

[0084] (A) Weigh 200 grams of three-year-old whole Zhejiang Ophiopogon japonicus, 30 grams of five-year-old ginseng, 60 grams of smoked plum, 30 grams of cornel, and 30 grams of cistanche;

[0085] Steps (B)-(D) are the same as those in Example 7.

[0086] Example 10

[0087] A preparation method of a traditional Chinese medicine composition teabag for preventing and treating upper-consumption type diabetes mellitus, comprising the following steps:

[0088] ① Weigh 100 grams of three-year-old whole Zhejiang Ophiopogon japonicus, 30 grams of five-year-old ginseng, 30 grams of smoked plum, 30 grams of lily, and 30 grams of reed rhizome;

[0089] ② Wash the three-year-old whole Zhejiang Ophiopogon japonicus clean, cut it into sections with a length of 2.0 cm, and dry it in the sun until the water content is 13% for later use;

[0090] ③Crush the three-year-old whole Zhefritillariae Thunbergii roots, five-year-old ginseng, smoked plums, lilies, and phragmites rhizomes into powder, and sieve it through a 60-mesh sieve for later use;

[0091] ④Weigh 10 grams of the mixed powder obtained in step ③ per bag and package it into teabags.

[0092] Example 11

[0093] A preparation method of a teabag of a traditional Chinese medicine composition for preventing and treating middle-stage diabetes includes the following steps:

[0094] ①Weigh 100 grams of three-year-old whole Zhefritillariae Thunbergii roots, 30 grams of five-year-old ginseng, 30 grams of smoked plums, 30 grams of phyllanthus emblica, 30 grams of tangerine peel, and 60 grams of lotus seeds;

[0095] Step ② - Wash the three-year-old whole Zhefritillariae Thunbergii roots clean, cut them into sections with a length of 2.0 cm, and dry them in the sun until the water content is 13% for later use;

[0096] ③Crush the three-year-old whole Zhefritillariae Thunbergii root sections, five-year-old ginseng, smoked plums, phyllanthus emblica, tangerine peel, and lotus seeds into powder, and sieve it through a 60-mesh sieve for later use;

[0097] ④Weigh 10 grams of the powder obtained in step ③ per bag and package it into teabags.

[0098] Example 12

[0099] A preparation method of a teabag of a traditional Chinese medicine composition for preventing and treating lower-stage diabetes includes the following steps:

[0100] ①Weigh 100 grams of three-year-old whole Zhefritillariae Thunbergii roots, 30 grams of five-year-old ginseng, 30 grams of smoked plums, 60 grams of cornelian cherries, and 60 grams of cistanches;

[0101] ②Wash the three-year-old whole Zhefritillariae Thunbergii roots clean, cut them into sections with a length of 2.0 cm, and dry them in the sun until the water content is 13% for later use;

[0102] ③Crush the three-year-old whole Zhefritillariae Thunbergii root sections, five-year-old ginseng, and smoked plums into powder, and sieve it through a 60-mesh sieve for later use;

[0103] ④Store the cornelian cherries and cistanches at -15°C for 48 hours, then crush them into powder and sieve it through a 60-mesh sieve for later use;

[0104] ⑤Mix the powders obtained in steps ③ and ④ evenly for later use;

[0105] ⑥Weigh 10 grams of the mixed powder obtained in step ⑤ per bag and package it into teabags.

[0106] Example 13

[0107] A preparation method of a traditional Chinese medicine composition preparation for preventing and treating upper-stage diabetes includes the following steps:

[0108] (a) Weigh 200 g of three-year-old whole Ophiopogon japonicus, 60 g of five-year-old ginseng, 60 g of smoked plum, 150 g of lily, and 60 g of reed rhizome;

[0109] (b) Wash the three-year-old whole Ophiopogon japonicus thoroughly, cut it into segments with a length of 2.0 cm, and dry it in the sun until the water content is 13% for later use;

[0110] (c) Mix the segments of three-year-old whole Ophiopogon japonicus, smoked plum, lily, and reed rhizome, and decoct them with water twice. For the first time, add 10 times the amount of water and decoct for 2 hours at a decocting temperature of 100 °C, filter, add 10 times the amount of water to the filter residue and decoct for 1.5 hours at a decocting temperature of 100 °C, filter, and combine the two filtrates for later use to obtain a water extract;

[0111] (d) After pulverizing the five-year-old ginseng and passing it through a 20-mesh sieve, use 75% ethanol with a mass 5 times that of the five-year-old ginseng as a solvent, macerate for 24 hours and then perform percolation, collect the percolate, which is the ethanol extract. Combine the water extract and the percolate, mix them evenly and filter to obtain a medicinal liquid mixture.

[0112] Example 14

[0113] A preparation method of a traditional Chinese medicine composition preparation for preventing and treating middle-stage diabetes mellitus includes the following steps:

[0114] (a) Weigh 200 g of three-year-old Ophiopogon japonicus, 60 g of five-year-old ginseng, 60 g of smoked plum, 60 g of Phyllanthus emblica, 60 g of tangerine peel, and 200 g of lotus seeds;

[0115] (b) Wash the three-year-old whole Ophiopogon japonicus thoroughly, cut it into segments with a length of 2.0 cm, and dry it in the sun until the water content is 13% for later use;

[0116] (c) Mix the segments of three-year-old whole Ophiopogon japonicus, smoked plum, Phyllanthus emblica, tangerine peel, and lotus seeds, and decoct them with water twice. For the first time, add 10 times the amount of water and decoct for 2 hours at a decocting temperature of 100 °C, filter, add 10 times the amount of water to the filter residue and decoct for 1.5 hours at a decocting temperature of 100 °C, filter, and combine the two filtrates for later use to obtain a water extract;

[0117] (d) After pulverizing the five-year-old ginseng and passing it through a 20-mesh sieve, use 75% ethanol with a mass 5 times that of the five-year-old ginseng as a solvent, macerate for 24 hours and then perform percolation, collect the percolate, which is the ethanol extract. Combine the water extract and the percolate, mix them evenly and filter to obtain a medicinal liquid mixture.

[0118] Example 15

[0119] A preparation method of a traditional Chinese medicine composition preparation for preventing and treating lower-stage diabetes mellitus includes the following steps:

[0120] (a) Weigh 200 g of three-year-old whole Ophiopogon japonicus, 30 g of five-year-old ginseng, 60 g of smoked plum, 30 g of cornelian cherry fruit, and 30 g of cistanche;

[0121] (b) Wash the three-year-old whole Zhejiang Ophiopogon japonicus plants, cut them into segments 2.0 cm long, and dry them in the sun until the water content is 13% for later use;

[0122] (c) Mix the three-year-old whole Zhejiang Ophiopogon japonicus segments, smoked plums, cornel fruits, and cistanches, decoct them twice with water. For the first time, add 10 times the amount of water and decoct for 2 hours at a decocting temperature of 100 °C, filter, add 10 times the amount of water to the filter residue and decoct for 1.5 hours at a decocting temperature of 100 °C, filter, and combine the two filtrates for later use to obtain a water extract;

[0123] (d) Crush the five-year-old ginseng and pass it through a 20-mesh sieve, use 75% ethanol with a mass 5 times that of the five-year-old ginseng as a solvent, impregnate for 24 hours and then perform percolation, collect the percolate, which is the ethanol extract. Combine and mix the water extract and the percolate evenly and filter to obtain a medicinal liquid mixture.

[0124] Effect experiment:

[0125] Test method: Construct a hyperglycemic mouse model to verify the hypoglycemic effect of the above traditional Chinese medicine formula composition.

[0126] Preparation process: Prepare 60 male mice at 6 months old. After normally feeding the mice for 7 days, randomly divide them into a normal group (20 mice) and a model group (40 mice). Starting from the 8th day, the normal group is fed with a conventional diet, and the mice in the model group are fed with a high-sugar and high-fat diet.

[0127] Test process: Dissolve streptozotocin in a citric acid buffer solution to prepare a 2% streptozotocin solution. Administer a single intraperitoneal injection of 2% streptozotocin to the mice to establish a diabetes model. The rats in the normal group are intraperitoneally injected with a citric acid buffer solution at a dose of 0.1 mL / 100 g. After 72 hours, collect blood from the tail veins of the mice in the model group. If the fasting blood glucose value of the mice is stably higher than 12.0 mmol / L for multiple consecutive times (2 - 3 times), it can be considered that the hyperglycemic model is successfully constructed. Finally, there are 40 successful model animals. Except for the normal group being given a normal diet, the remaining groups continue to be fed with a high-sugar and high-fat diet during the treatment process and are all given drug treatment. Randomly divide the 40 successfully modeled mice into four groups, with 10 mice in each group, namely groups A, B, C, and D.

[0128] Group A is fed with approximately 2 g of the traditional Chinese medicine tablets in Example 1, Group B is fed with approximately 2 g of the traditional Chinese medicine tablets in Example 2, Group C is fed with approximately 2 g of the traditional Chinese medicine tablets in Example 3, twice a day; the normal group and Group D are given an equal amount of normal saline. Administer the drugs twice a day for 30 consecutive days. Conduct a glucose tolerance test on the mice in each group on the 10th and 30th days of drug administration. After 30 days of drug administration, detect data such as the blood glucose values of the mice in each group, and the results are shown in the following table.

[0129] Table 1 Blood glucose values before and after treatment

[0130]

[0131]

[0132] Note: The data in the table are the average blood glucose levels 2 hours after feeding.

[0133] From the data in Table 1, it can be seen that the fasting blood glucose of mice decreased extremely significantly compared with the normal group after feeding the composition in each example of the present invention for 30 days. This shows that the traditional Chinese medicine formula composition for preventing and treating diabetes (wasting and thirsting syndrome) provided by the present invention has an obvious blood glucose lowering effect. It can also be seen from the results that the effect of Example 1 is better than that of Example 2 and Example 3, and the effects of Example 2 and Example 3 are not as obvious as that of Example 1.

[0134] It shows that the best effect of preventing and treating diabetes (wasting and thirsting syndrome) is achieved by using 15 parts of three-year-old whole plant of Ophiopogon japonicus, 5 parts of five-year-old ginseng, 5 parts of smoked plum, 9 parts of lily, and 5 parts of reed rhizome provided by the present invention.

[0135] Clinical treatment cases are as follows:

[0136] After randomly selecting 80 cases of diabetes patients to take the teabag agent made of the traditional Chinese medicine composition in Example 10 of the present invention, they were divided into three grades: marked effect, effective, and weak effect. The manifestation of marked effect is that there is no hyperglycemia throughout the day, the blood glucose 1 hour after meal is 7.8 - 9.0 mmol / L, and the blood glucose 2 hours after meal is 5.4 - 7.8 mmol / L. The manifestation of effective is that the fasting blood glucose < 8.5 mmol / L, the blood glucose 1 hour after meal < 10.0 mmol / L, the blood glucose 2 hours after meal is 5 - 9.0 mmol / L, and the clinical manifestations are that the symptoms are relieved, the blood glucose is controlled, and the complications are alleviated. The manifestation of ineffective is that the blood glucose reduction is not obvious and the complications are not significantly alleviated.

[0137] From October 2023 to December 2024, 160 patients were screened, including 70 males and 90 females. Among them, 80 individuals were used as the treatment group, and the treatment group took the teabag agent of the present invention. One bag was consumed every day, and when using it, it was necessary to use freshly boiled water and soak it in a thermos cup for 2 hours. 80 individuals were used as the control group, and the control group took the western medicine metformin for improving insulin resistance.

[0138] The selection criteria were that the patients met the symptoms of type II diabetes and had not used insulin for at least 10 days. The medication treatment effects of the treatment group and the control group are shown in Table 2 below:

[0139] Table 2 Effects after 3 months of treatment

[0140] Total patients Marked effect Effective Ineffective Effective rate / % Treatment group 80 55 20 5 93.75 Control group 80 50 10 10 75.0

[0141] Typical cases

[0142] Case 1: Li, male, age: 52, diagnosis: type 2 diabetes mellitus with polyuria, used the teabag of Example 10. Fasting blood glucose before taking: 9.2, fasting blood glucose after taking: 7.5, 2-hour postprandial blood glucose before taking: 9.6, 2-hour postprandial blood glucose after taking: 8.8. The therapeutic effect on type 2 diabetes mellitus is effective. After taking the above oral medicine for 2 months, the symptom of polyuria was significantly improved.

[0143] Case 2: Zhang, female, age: 48, diagnosis: type 2 diabetes mellitus with polydipsia and polyphagia, used the teabag of Example 11. Fasting blood glucose before taking: 8.8, fasting blood glucose after taking: 7.2, 2-hour postprandial blood glucose before taking: 9.9, 2-hour postprandial blood glucose after taking: 7.5. The therapeutic effect on type 2 diabetes mellitus is marked. After taking the above oral medicine for four months, the symptoms of polyphagia and polydipsia were significantly improved.

[0144] Case 3: Wang, female, age: 46, diagnosis: type 2 diabetes mellitus with polydipsia, used the teabag of Example 12. Fasting blood glucose before taking: 8.2, fasting blood glucose after taking: 6.5, 2-hour postprandial blood glucose before taking: 8.6, 2-hour postprandial blood glucose after taking: 7.7. The therapeutic effect on type 2 diabetes mellitus is marked. After continuously taking the above medicine for six months, the symptom of polydipsia disappeared.

[0145] None of the above three treatment cases produced side effects, and the present invention has a significant therapeutic effect on diabetes.

[0146] The description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the broadest scope consistent with the principles and novel features disclosed herein.

Claims

1. A Chinese medicine composition for preventing and treating diabetes, characterized in that: The Chinese medicine composition for treating upper-consumption type diabetes comprises the following raw materials in parts by weight: 10-20 parts of three-year-old whole Ophiopogon japonicus, 3-6 parts of five-year-old ginseng, 3-6 parts of black plum, 3-15 parts of lily, and 3-6 parts of reed root; Or, the Chinese medicine composition for treating middle-type diabetes mellitus comprises the following raw materials in parts by weight: 10-20 parts of three-year-old whole plant of Ophiopogon japonicus, 3-6 parts of five-year-old ginseng, 3-6 parts of black plum, 3-6 parts of Phyllanthus emblica, 3-6 parts of orange peel, and 6-20 parts of lotus seeds; Or, the Chinese medicine composition for treating lower consumption type diabetes comprises the following raw materials in parts by weight: 10-20 parts of three-year-old whole plant Ophiopogon japonicus, 3-6 parts of five-year-old ginseng, 3-6 parts of black plums, 3-6 parts of cornus fruit, and 3-6 parts of Cistanche deserticola.

2. A Chinese medicine composition for preventing and treating diabetes according to claim 1, characterized in that: The Chinese medicine composition for treating upper-consumption type diabetes comprises the following raw materials in parts by weight: 10 parts of three-year-old whole Ophiopogon japonicus, 3 parts of five-year-old ginseng, 3 parts of black plum, 3 parts of lily, and 3 parts of reed root; Or, the Chinese medicine composition for treating middle-type diabetes mellitus comprises the following raw materials in parts by weight: 10 parts of three-year-old whole plant Ophiopogon japonicus, 3 parts of five-year-old ginseng, 3 parts of black plum, 3 parts of Phyllanthus emblica, 3 parts of orange peel, and 6 parts of lotus seeds; Or, the Chinese medicine composition for treating lower consumption type diabetes comprises the following raw materials in parts by weight: 10 parts of three-year-old whole plant Ophiopogon japonicus, 3 parts of five-year-old ginseng, 3 parts of black plums, 6 parts of Cornus officinalis, and 6 parts of Cistanche deserticola.

3. A Chinese medicine composition for preventing and treating diabetes according to claim 1, characterized in that: The Chinese medicine composition for treating upper-consumption type diabetes comprises the following raw materials in parts by weight: 15 parts of three-year-old whole Ophiopogon japonicus, 5 parts of five-year-old ginseng, 5 parts of black plum, 9 parts of lily, and 5 parts of reed root; Or, the Chinese medicine composition for treating middle-type diabetes mellitus comprises the following raw materials in parts by weight: 15 parts of three-year-old whole plant Ophiopogon japonicus, 5 parts of five-year-old ginseng, 5 parts of black plum, 5 parts of Phyllanthus emblica, 5 parts of orange peel, and 12 parts of lotus seeds; Or, the Chinese medicine composition for treating lower consumption type diabetes comprises the following raw materials in parts by weight: 15 parts of three-year-old whole plant Ophiopogon japonicus, 5 parts of five-year-old ginseng, 5 parts of black plums, 4 parts of Cornus officinalis, and 4 parts of Cistanche deserticola.

4. A Chinese medicine composition for preventing and treating diabetes according to claim 1, characterized in that: The Chinese medicine composition for treating upper-consumption type diabetes comprises the following raw materials in parts by weight: 20 parts of three-year-old whole Ophiopogon japonicus, 6 parts of five-year-old ginseng, 6 parts of black plum, 15 parts of lily, and 6 parts of reed root; Or, the Chinese medicine composition for treating middle-type diabetes mellitus comprises the following raw materials in parts by weight: 20 parts of three-year-old whole plant Ophiopogon japonicus, 6 parts of five-year-old ginseng, 6 parts of black plum, 6 parts of Phyllanthus emblica, 6 parts of orange peel, and 20 parts of lotus seeds; Or, the Chinese medicine composition for treating lower consumption type diabetes comprises the following raw materials in parts by weight: 20 parts of three-year-old whole plant Ophiopogon japonicus, 3 parts of five-year-old ginseng, 6 parts of black plums, 3 parts of Cornus officinalis, and 3 parts of Cistanche deserticola.

5. Use of the Chinese medicine composition according to any one of claims 1 to 4 in the preparation of a Chinese medicine composition preparation for preventing and treating diabetes.

6. A method for preparing a Chinese medicine composition for preventing and treating diabetes, characterized in that: The following steps are involved: (1) Weighing each raw material according to the weight proportion of the Chinese medicine composition according to any one of claims 1 to 4; (2) The Chinese medicine composition is made into tea bags, mixtures, granules, tablets or pills.

7. The method for preparing a Chinese medicine composition for preventing and treating diabetes according to claim 6, characterized in that: The following steps are involved: ① Weigh each raw material according to the weight proportion of the Chinese medicine composition according to any one of claims 1 to 4; ②Wash the three-year-old whole plant of Ophiopogon japonicus, cut it into 2.0 cm long segments or 0.5 cm thick slices, and sun-dry or oven-dry it until the moisture content is 13% for later use; ③ Crush the three-year-old whole plant of Ophiopogon japonicus, five-year-old ginseng, black plum, lily, emblica, reed root, orange peel and lotus seeds through a 60-mesh sieve for later use; ④ After storing the cornus fruit and the dried cornel pulp at -15℃ for 48 hours, crush them through a 60-mesh sieve for later use; ⑤ Evenly mix the powders obtained in steps ③ and ④ for later use; ⑥ Weigh the mixed powder obtained in step ⑤ to 10-15 g / bag and package it into tea bags.

8. The method for preparing a Chinese medicine composition for preventing and treating diabetes according to claim 6, characterized in that: The following steps are involved: (A) weighing each raw material according to the weight proportion of the Chinese medicine composition according to any one of claims 1 to 4; (B) Clean the whole plant of three-year-old Ophiopogon japonicus, cut it into 2.0 cm long segments or 0.5 cm thick slices, and sun-dry or oven-dry it to a moisture content of 13% for later use; (C) Prepare water extracts from three-year-old whole-plant Ophiopogon japonicus segments or slices, black plum, lily, reed root, emblica fruit, orange peel, lotus seed, Cistanche deserticola and cornus fruit according to a conventional method, grind ginseng into powder and mix with the water extract, and prepare granules, tablets or pills according to a conventional method.

9. The method for preparing a Chinese medicine composition for preventing and treating diabetes according to claim 6, characterized in that: The following steps are involved: (a) weighing each raw material according to the weight proportion of the Chinese medicine composition according to any one of claims 1 to 4; (b) washing the whole plant of three-year-old Ophiopogon japonicus, cutting it into 2.0 cm long segments or 0.5 cm thick slices, and drying it in the sun or in an oven until the moisture content is 13% for later use; (c) preparing water extracts from three-year-old whole-plant Ophiopogon japonicus segments or slices, black plum, lily, reed root, emblica fruit, orange peel, lotus seed, Cistanche deserticola and cornus fruit according to a conventional method, and preparing ethanol extracts from ginseng by crushing it into coarse powder according to a conventional method, combining the obtained water extract and ethanol extract, and preparing a mixture according to a conventional method.

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