Impurity removal and purification equipment for crude heparin sodium

Abstract

The invention relates to the technical field of crude heparin sodium processing, in particular to crude heparin sodium impurity removal and purification equipment which comprises a system frame and an impurity removal and purification system erected on the system frame. A primary screening compartment is arranged at the feeding end of the impurity removal system, and double-layer staggered rotary crushing rollers are arranged in the primary screening compartment; the turnover flow guide box is provided with a hydraulic drive spiral flow guide plate; the filtering device comprises upper-layer transverse stainless steel filtering wires and lower-layer longitudinal ceramic filtering wires; the crystallizer is provided with a gradient cooling condensation module. The purification system comprises a centrifugal separator, a preheating guide cylinder and a dryer, the centrifugal separator is in butt joint with the crystallizer through a purification guide-in box, the bottom of the centrifugal separator is connected with the preheating guide cylinder through a heparin sodium guide-out cylinder, a steam jacket and a spiral blade are arranged in the centrifugal separator, the outlet end of the centrifugal separator is connected with the dryer, and a vacuumizing assembly is integrated on the side edge of the dryer. Through integrated design of crushing, crystallization, preheating and intelligent control, efficient impurity removal and purification of the crude heparin sodium are realized, and the product purity and the production efficiency are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of crude heparin sodium processing, and specifically to an impurity removal and purification device for crude heparin sodium. Background Art

[0002] In order to solve the impurity removal problem in the traditional process, some impurity removal and purification devices have been applied to the production of crude heparin sodium, including an impurity removal tank and a sedimentation tank. A hollow partition is fixedly installed between the inner side walls of the impurity removal tank, and a copper tube heating pipe is installed in the inner cavity of the hollow partition. A through hole is provided at the inner bottom end of the hollow partition, and a filter cylinder is provided at the top end of the through hole. A movable block is provided at the top end of the hollow partition, and a pull rod is fixedly connected between the movable block and the inner side wall of the impurity removal tank. A leakage hole is provided at the bottom end of the movable block, and the pull rod is connected to the leakage hole through the movable block.

[0003] However, the existing technical structure still has certain technical defects. During the impurity removal process, natural cooling or a single temperature control mode is likely to cause crystals to entrap impurities, resulting in fluctuations in the purity of the finished product. The drying system has high energy consumption and poor vacuum stability, and requires secondary treatment. In this state of multiple treatments, not only is the production efficiency low, but it is also easy to damage the internal molecular structure of heparin sodium. Summary of the Invention

[0004] The purpose of the present invention is to provide an impurity removal and purification device for crude heparin sodium to solve the problems raised in the above background art.

[0005] To achieve the above purpose, the present invention provides the following technical solutions:

[0006] An impurity removal and purification device for crude heparin sodium includes a system framework, an impurity removal system and a purification system mounted on the system framework. The impurity removal system includes an upper edge support, on which a preliminary screening chamber, a turnover diversion chamber, a filtering device and a crystallizer are arranged in sequence. Among them: The preliminary screening chamber is arranged at the feeding end of the impurity removal system, and a crushing component composed of double-layer staggered rotating crushing rollers is installed inside; A hydraulically driven spiral deflector is provided in the turnover diversion chamber; The filtering device includes upper-layer horizontal stainless steel filter wires and lower-layer vertical ceramic filter wires; A gradient cooling condensation module is configured in the crystallizer; The purification system includes a centrifuge separator, a preheating guide cylinder and a dryer. Among them: The centrifuge separator is docked with the crystallizer through a purification introduction box, and its bottom is connected to the preheating guide cylinder through a heparin sodium extraction cylinder; The preheating guide cylinder is internally provided with a steam jacket and spiral blades, and conveys crystals through spiral propulsion. The outlet end of the preheating guide cylinder is connected to the dryer; A vacuum pumping component is integrated on the side edge of the dryer.

[0007] As a further solution of the present invention: the preliminary screening chamber is provided with an inlet and impurity removal bucket, a dust outlet is provided at the bottom, and a guide frame plate is provided at the top; the guide frame plate is adjusted to an inclination angle of degrees by a hydraulic push rod, and one end is connected to the access end, and the other end is guided to the roller gap of the crushing roller.

[0008] As a further solution of the present invention: the crushing roller pair includes two parallel crushing rollers, each roller consists of a support plate and a crushing roller body; the support plate is connected to the inner wall of the preliminary screening chamber through an annular positioning bolt group, and an elastic gasket is provided between the support plate and the chamber wall; the roller shaft of the crushing roller body is installed on the support plate through a support bearing. A plurality of crushing steel wires are distributed in an annular array on the roller surface of the crushing roller body, and the steel wires are curved inward; a counterweight head is welded at the end of the crushing steel wire, and the counterweight head generates a centrifugal impact force when the roller body rotates, triggering micro-vibration at the root of the steel wire.

[0009] As a further solution of the present invention: the crystallizer includes a mounting frame and a crystallization chamber mounted on the mounting frame, the mounting frame and the crystallization chamber form an integrated communication structure, and the crystallization chamber is connected to the filtering device through an inlet.

[0010] As a further solution of the present invention: the condensation module includes a condensation base plate, a cooling boss and a cooling main frame; the condensation base plate is provided with an output port connected to the purification inlet box; the condensation base plate of the crystallizer is built with a stainless steel cooling coil, and the coil is externally connected to an ethylene glycol aqueous solution circulation system; a guide bracket is vertically installed on the surface of the cooling boss, and a condenser is fixed on the top of the guide bracket; the condenser is actively cooled to 0-10°C, and the guide groove of the guide bracket causes the solution to form a vortex.

[0011] As a further solution of the present invention: the centrifugal separator includes a centrifugal kettle and a kettle bucket arranged at the bottom of the centrifugal kettle, the top of the centrifugal kettle is provided with an access end connected to the purification inlet box, the bottom of the kettle bucket is provided with a crystallization output pump, and the side edge of the centrifugal kettle is externally connected with a solution output pipe.

[0012] As a further solution of the present invention: the main body of the preheating guide cylinder is a lead-out cylinder, one end of the lead-out cylinder is provided with a lead-out cylinder, the lead-out cylinder is externally connected to a sodium heparin lead-out cylinder, the sodium heparin lead-out cylinder is connected to a crystallization output pump, and the other end of the lead-out cylinder is provided with a drying turnover cylinder, which is connected to a dryer.

[0013] As a further solution of the present invention: a steam jacket is provided on the inner wall of the outlet tube, a heating branch pipe is externally connected to the outlet tube, and the gas supply end of the heating branch pipe is connected to the steam jacket.

[0014] As a further solution of the present invention: the inner cavity of the outlet cylinder is provided with a spiral sheet, the cylinder end of the outlet cylinder is provided with a supercharger and a supercharger pump driving the supercharger, and the power output end of the supercharger is connected to the spiral sheet.

[0015] As a further solution of the present invention: the drying rotary drum includes a rotary drum body and a drop bin installed at the bottom of the rotary drum body, and a detector is arranged on the side edge of the drop bin; the detector includes a detection frame and a detection support frame installed on the detection frame, and a detection through pipe is arranged at the detection end of the detection support frame, and the detection through pipe is connected to the drop bin through an airflow branch drum.

[0016] As a further solution of the present invention: a pneumatic support piece is provided on the detection support frame, and the pneumatic support piece is installed on the sensing end of the detection support frame through an elastic sensing end.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] 1. Combining efficient crushing with dynamic filtration to improve impurity removal efficiency. Through the double-layer staggered rotating crushing rollers, the arc-shaped inward-bending crushing wires and the counterweight head, a shear crushing chamber is formed to achieve powerful crushing of crude heparin sodium. At the same time, the spiral guide structure and filtration device are used to intercept impurities of different particle sizes in layers to provide a high-purity solution for subsequent crystallization.

[0019] 2. Gradient cooling crystallization and centrifugal separation work together to optimize crystal purity. The crystallizer uses a dual mechanism of passive cooling and active refrigeration to achieve a gradient cooling of the solution from 40°C to 5-10°C, inducing rapid and uniform precipitation of heparin sodium. The vortex design of the flow guide bracket prolongs the residence time of the solution, and the crystal particles grow more completely. The centrifugal separator discharges the mother liquor and crystals through high-speed centrifugal classification, and the anti-stick coating of the conical kettle bucket reduces residue. The final crystal purity is ≥95%, and the crystallization yield is increased by 25%.

[0020] 3. The spiral preheating is linked with vacuum drying to reduce energy consumption and ensure the quality of the finished product. The preheating guide cylinder is pushed by the vortex of the steam jacket and the spiral blade to preheat the crystal to 40-50°C and evenly disperse the moisture. The dryer is combined with the condensation function of the vacuum pumping component under a vacuum environment of -0.09MPa to quickly evaporate the moisture and avoid high-temperature denaturation. The detector monitors the material flow in real time, responds to pressure changes (0.5-5kPa) through the pneumatic support, and automatically adjusts the drying parameters with the integrated control system programmed by PLC.

[0021] The present invention realizes efficient purification of crude products through integrated design of crushing, crystallization, preheating and intelligent control, significantly improving product purity and production efficiency. The system combines dynamic filtration with low-temperature vacuum drying to avoid molecular degradation caused by high temperature and high pressure, ensure the biological activity of heparin sodium, and realize continuous and stable production.

[0022] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and do not limit this application. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The drawings herein are incorporated into the specification and form a part of this specification, showing embodiments consistent with this application, and are used together with the specification to explain the principles of this application. At the same time, these drawings and the written description are not intended to limit the scope of the concept of this application in any way, but to illustrate the concept of this application to those skilled in the art by reference to specific embodiments.

[0024] Figure 1 It is a schematic diagram of the overall structure of the crude heparin sodium impurity removal and purification equipment provided by an embodiment of the present invention.

[0025] Figure 2 It is a schematic diagram of the internal structure of the preliminary screening chamber provided by an embodiment of the present invention.

[0026] Figure 3 For the present invention Figure 2 a schematic diagram of the structure of area A therein.

[0027] Figure 4 It is a schematic diagram of the structure of the crystallizer provided by an embodiment of the present invention.

[0028] Figure 5 It is a schematic diagram of the structure of the centrifuge separator provided by an embodiment of the present invention.

[0029] Figure 6 It is a schematic diagram of the structure of the crystallizer provided by an embodiment of the present invention.

[0030] Figure 7 It is a schematic diagram of the structure of the preheating guide cylinder provided by an embodiment of the present invention.

[0031] Figure 8 For the present invention Figure 6 a schematic diagram of the structure of area B therein.

[0032] In the figure: 1. System frame; 11. Upper bracket; 12. Crushing assembly; 121. Linkage drive; 122. Crushing roller; 123. Support plate; 124. Crushing roller body; 125. Positioning bolt group; 126. Support bearing; 127. Crushing wire; 128. Counterweight head; 13. Preliminary screening chamber; 131. Introducing impurity removal bucket; 132. Dust outlet; 133. Guide frame plate; 134. Dust screening mesh plate; 14. Circulation guide chamber; 15. Filter device; 16. Crystallizer; 161. Mounting frame; 162. Crystallization chamber; 163. Condensation bottom plate; 164. Cooling coil; 165. Cooling boss; 166. Cooling main frame; 167. Output port; 168. Introducing port; 1661. Guide bracket; 1662. Condenser; 21. Support frame ; 22. Centrifugal separator; 23. Purification introduction box; 24. Heparin sodium lead-out tube; 25. Preheating guide tube; 26. Dryer; 27. Vacuum assembly; 221. Centrifugal kettle; 222. Kettle; 223. Access end; 224. Solution output pipe; 225. Crystallization output pump; 251. Lead-out tube; 252. Power output device; 253. Drive motor; 254. Drying rotary cylinder; 2541. Rotating cylinder body; 2542. Drop bin; 255. Detector; 256. Heating branch pipe; 2551. Airflow branch cylinder; 2552. Detection through pipe; 2553. Detection support frame; 2554. Pneumatic support sheet; 2555. Elastic sensing end; 2556. Detection frame; 257. Access head; 258. Spiral sheet; 259. Steam jacket; 250. Preheating chamber. DETAILED DESCRIPTION

[0033] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention, and examples thereof are shown in the accompanying drawings. When the following description refers to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements.

[0034] Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] The specific implementation of the present invention is described in detail below in conjunction with specific embodiments.

[0036] For example, see Figure 1, provides a crude heparin sodium impurity removal and purification device, including a system frame 1 and an impurity removal system and a purification system mounted on the system frame 1; the impurity removal system is provided with an upper bracket 11, and the upper bracket 11 is sequentially provided with a preliminary screening box 13, a turnover guide box 14, a filtering device 15 and a crystallizer 16, the preliminary screening box 13 is arranged at the feeding end of the impurity removal system, and a crushing component 12 is arranged in the preliminary screening box 13; the purification system includes a centrifugal separator 2 2. Preheating guide cylinder 25 and dryer 26. The frame of the system frame 1 is provided with a support frame 21. The centrifuge 22 is supported and installed on the support frame 21. The top of the centrifuge 22 is connected to the crystallizer 16 through the purification introduction box 23. The bottom of the centrifuge 22 is provided with a sodium heparin lead-out cylinder 24 connected to the preheating guide cylinder 25. The terminal of the preheating guide cylinder 25 is connected to the dryer 26, and a vacuum assembly 27 is provided on the side edge of the dryer 26.

[0037] This embodiment is used for the impurity removal and purification of crude sodium heparin, and mainly includes two parts: impurity removal and purification. The impurity removal system, the preliminary screening chamber 13 is used for feeding and screening out dust, and the crushing component 12 adopts a double-layer staggered rotating crushing roller to crush the agglomerated sodium heparin raw material to improve the subsequent dissolution efficiency. The inner wall of the guide plate of the turnover guide chamber 14 is designed with a spiral guide structure, and the guide angle is adjusted by hydraulic drive to achieve uniform distribution of materials and prevent local accumulation. The filter device 15 has a built-in double-layer filtration structure: Upper filter plate: horizontal stainless steel filter wire (diameter 0.5mm) is arranged to intercept fiber impurities. Lower filter plate: longitudinal ceramic filter wire (diameter 0.3mm), which can be moved vertically to form a dynamic filtration grid to prevent clogging. Purification system, the centrifugal separator 22 separates the crystals and the mother liquor, and discharges them in stages by centrifugal force. The preheating guide cylinder 25 pushes the material and permeates the steam through the spiral blades. The preheating temperature is stabilized at 60-70°C. The vacuum pump component 27 integrates the vacuum pump and the condenser. The vacuum degree in the dryer 26 is maintained at -0.09MPa to accelerate the evaporation of water.

[0038] After the raw materials are crushed by the crushing component 12, they are preliminarily screened by a vibrating screen, and the screened dust is intercepted. The screened materials enter the turnover diversion box 14, and the spiral diversion plate guides the solution to flow evenly to the filtering device 15. The double-layer filtering grid intercepts impurities with different particle sizes. After filtration, the solution flows into the crystallizer 16, and gradient cooling (50°C → 10°C) combined with stirring (30 rpm) promotes crystal precipitation. In the purification stage, the crystal mixture enters the centrifuge 22 through the purification introduction box 23. The mother liquor and crystals are separated by high-speed centrifugation, and the crystals slide along the diversion groove into the heparin sodium extraction cylinder 24. The crystals are spirally conveyed through the preheating guide cylinder 25, and the steam jacket is heated to reduce the moisture content to 15% - 20%. After preheating, the materials enter the dryer 26 for deep dehydration. The vacuum pumping component 27 maintains a dry environment, and finally, heparin sodium products with a purity ≥ 95% are obtained. Overall control system: Based on PLC programming, it synchronously adjusts the rotation speed of the crushing component 12, the load of the centrifuge 22, and the temperature of the preheating guide cylinder 25 to achieve full-process automation.

[0039] Example 2. Please refer to Figure 1 、 Figure 2 and Figure 3 , based on the content described in the above embodiments, for the internal structure of the preliminary screening box 13, the design of this embodiment is as follows:

[0040] An import impurity removal hopper 131 is arranged in the preliminary screening box 13. The import impurity removal hopper 131 is arranged at the front edge of the crushing component 12. A dust falling port 132 is arranged at the bottom of the import impurity removal hopper 131, and a guiding frame plate 133 is arranged at the top of the import impurity removal hopper 131. The crushing component 12 includes a linkage drive 121 and crushing counter-rollers 122 installed on the linkage drive 121. One end of the guiding frame plate 133 is docked with the access end 223 of the preliminary screening box 13, and the other end of the guiding frame plate 133 is guided into the roller gap of the crushing counter-rollers 122. The crude heparin sodium raw materials enter the import impurity removal hopper 131 from the access end 223, are filtered by the filter screen, and minute dust (particle size ≥ 0.8 mm) is adsorbed by the filter screen. The purified heparin sodium particles flow along the guiding frame plate 133. The guiding frame plate 133 is adjusted to the optimal angle (usually set at 25°) by a hydraulic push rod, and the materials enter the gap between the crushing counter-rollers 122 at a uniform flow rate. The crushed heparin sodium particles (80% particle size ≤ 2 mm) directly fall onto the downstream conveyor belt.

[0041] The crushing counter-rollers 122 include two crushing roller members arranged side by side. The crushing roller members include support disks 123 installed in the preliminary screening box 13 and crushing roller bodies 124 installed between the support disks 123. Support bearings 126 are arranged on the support disks 123, the roller shafts of the crushing roller bodies 124 pass through the support bearings 126, and a circle of positioning bolt groups 125 is installed between the support disks 123 and the inner box wall of the preliminary screening box 13.

[0042] The crushing roller pair 122 is composed of two parallel crushing rollers, each of which includes a support plate 123 and a crushing roller body 124. The double rollers realize synchronous reverse rotation with the linkage driver through the support bearing 126 to form a shear crushing chamber 34. The roller body spacing is adjusted by the positioning bolt group 125 of the support plate 123 (1-5mm) to meet the crushing requirements of materials with different hardness 46. The support plate 123 is made of high-strength alloy material and is rigidly connected to the inner wall of the preliminary screening chamber 13 through a circle of annular positioning bolt groups 125 to ensure the axial stability of the roller body and reduce the risk of vibration deviation. An elastic gasket is set between the support plate 123 and the chamber wall to buffer the crushing impact force and extend the life of the equipment. After the material enters the preliminary screening chamber 13, it falls evenly into the gap between the double rollers through the guide structure and is crushed by the shear force generated by the reverse rotation of the roller body.

[0043] A plurality of crushing wires 127 are arranged on the roller surface of the crushing roller body 124. The crushing wires 127 are arranged in rows, and each row of crushing wires 127 is arranged in a circular array on the roller surface of the crushing roller body 124. The crushing wires 127 are curved inward, and a counterweight head 128 is arranged at the wire end of the crushing wire 127.

[0044] The crushing wire 127 adopts a circular array layout design. The crushing wire 127 is distributed on the roller surface in a circular array in rows, with a spacing of 15-20mm between each row, forming a spiral guide track to enhance the uniform distribution of materials in the axial direction of the roller. The steel wire is curved inward (bending radius 10-15mm), and the bending angle (30°-45°) is optimized through mechanical simulation to guide the material to gather in the center of the roller gap to avoid leakage at the edge. The tungsten alloy counterweight head 128 (single weight 5-8g) is welded at the end of the steel wire, which generates periodic impact force through centrifugal force to improve the penetration and crushing efficiency of hard agglomerates in crude heparin sodium. At the same time, the counterweight head 128 rubs against the material during rotation, triggering micro-vibration at the root of the steel wire (amplitude ≤0.3mm), reducing the risk of entanglement of fiber materials.

[0045] For example 3, please refer to Figure 1 and Figure 4 Based on the contents of the above embodiment, the specific implementation structure of the crystallizer 16 is designed as follows:

[0046] The crystallizer 16 includes a mounting frame 161 and a crystallization chamber 162 mounted on the mounting frame 161. The mounting frame 161 and the crystallization chamber 162 form an integrated communication structure. The crystallization chamber 162 is connected to the filtering device 15 through an inlet 168. A condensation bottom plate 163 is provided at the bottom of the inner cavity of the crystallization chamber 162. The condensation bottom plate 163 is provided with an output port 167 connected to the purification inlet box 23.

[0047] A cooling coil 164 is provided on the plate body of the condensation bottom plate 163. A cooling boss 165 is installed on the plate surface of the condensation bottom plate 163, and a cooling main frame 166 is installed on the cooling boss 165; the cooling main frame 166 includes a number of diversion brackets 1661 and a condenser 1662 installed on the diversion brackets 1661;

[0048] The installation sleeve frame 161 is fixedly connected to the outer support bracket, providing support and a sealed environment for the crystallization chamber 162, forming an integrated communication cavity. The top of the crystallization chamber 162 is connected to the filtration device 15 through the inlet 168, and the bottom is connected to the purification inlet box 23 through the outlet 167, and the internal volume can accommodate 100 - 200L.

[0049] The internal condensation module thereof includes a condensation bottom plate 163, a cooling boss 165 and a cooling main frame 166,

[0050] The condensation bottom plate 163 is located at the bottom of the crystallization chamber 162, and is internally provided with a stainless - steel cooling coil 164 (with a diameter of 10 - 15mm). The coil is externally connected to a circulating coolant (such as an ethylene glycol aqueous solution), and the temperature control range is 5 - 30°C. The cooling boss 165 is welded to the surface of the condensation bottom plate 163 to increase the heat dissipation area. The diversion brackets 1661 are vertically installed on the cooling boss 165, made of 304 stainless steel, and are provided with diversion grooves on the surface to guide the solution to flow along a fixed path. The condenser 1662 is fixed to the top of the diversion brackets 1661, and is a semiconductor refrigeration sheet or a micro - compressor refrigeration module, which can actively cool down to 0 - 10°C to accelerate the crystallization precipitation.

[0051] The filtered heparin sodium solution enters the crystallization chamber 162 through the inlet 168, first contacts the cooling coil 164 of the condensation bottom plate 163, and the solution is cooled from the initial temperature (such as 40°C) to 25 - 30°C through the circulating coolant, promoting the preliminary precipitation of impurities. And it is designed with a gradient cooling mechanism. The condenser 1662 of the cooling main frame 166 actively cools a local area (such as near the diversion brackets 1661) to 5 - 10°C, inducing the rapid crystallization of heparin sodium. The diversion grooves of the diversion brackets 1661 are designed to make the solution form a vortex, extending the residence time to ensure the full growth of crystal particles. The crystallized mixture enters the purification inlet box 23 through the outlet 167 of the condensation bottom plate 163. The impurities precipitate at the bottom of the crystallization chamber 162 (which can be discharged regularly), and the heparin sodium crystal suspension enters the subsequent centrifugation separation process. This embodiment can achieve efficient gradient cooling. The dual - cooling design of the cooling coil 164 (passive cooling) + condenser 1662 (active refrigeration) increases the crystallization speed by 40%, and the crystal particle size is uniform.

[0052] Example Four, please refer to Figure 1 and Figure 5Based on the contents of the above embodiment, the specific implementation structure of the centrifugal separator 22 is designed as follows:

[0053] The centrifugal separator 22 includes a centrifugal kettle 221 and a kettle bucket 222 arranged at the bottom of the centrifugal kettle 221. The top of the centrifugal kettle 221 is provided with an access end 223 connected to the purification introduction box 23. The bottom of the kettle bucket 222 is provided with a crystallization output pump 225. The side edge of the centrifugal kettle 221 is externally connected to a solution output pipe 224.

[0054] The main body of the centrifugal separator 22 is a centrifugal kettle 221 and a kettle bucket 222. The centrifugal kettle 221 is provided with a centrifugal grid inside, with a rotation speed range of 2000-4000rpm, and can accommodate 50-100L of mixed liquid. The bottom of the kettle bucket 222 adopts a conical design, and the surface is coated with a polytetrafluoroethylene anti-sticking layer. It is connected to the crystallization output pump 225 through a flange to achieve directional output of crystallized particles. 35. The access end 223 is connected to the purification introduction box 23 through a sealing clamp, and a silicone sealing ring is embedded in the interface to prevent liquid leakage during centrifugation. 68. The solution output pipe 224 is externally connected to the side edge of the centrifugal kettle 221, and an adjustable valve (such as a butterfly valve) is built in. The upper clear liquid after stratification is discharged to the recovery and processing process through the solution output pipe 224, and the lower crystallized mixed liquid is output in a directional manner through the crystallization output pump 225.

[0055] For example 5, please refer to Figure 1 , Figure 6 , Figure 7 and Figure 8 Based on the contents of the above embodiment, the specific implementation structure of the preheating guide cylinder ‌25 is designed as follows:

[0056] The main body of the preheating guide cylinder 25 is a lead-out cylinder 251, one end of which is provided with a lead-out cylinder 251, the lead-out cylinder 251 is externally connected to a sodium heparin lead-out cylinder 24, the sodium heparin lead-out cylinder 24 is connected to a crystallization output pump 225, and the other end of the lead-out cylinder 251 is provided with a drying circulation cylinder 254, which is connected to a dryer 26.

[0057] The inner wall of the outlet tube 251 is provided with a steam jacket 259, and the outlet tube 251 is externally connected with a heat supply branch pipe 256, and the gas supply end of the heat supply branch pipe 256 is passed into the steam jacket 259. The inner cavity of the outlet tube 251 is provided with a spiral sheet 258, and the barrel end of the outlet tube 251 is provided with a power output device 252 and a driving motor 253 for driving the power output device 252, and the power output end of the power output device 252 is connected to the spiral sheet 258.

[0058] The cylinder body of the discharge cylinder 251 adopts a double-layer stainless steel structure, externally connected to the heparin sodium extraction cylinder 24 and the drying turnover cylinder 254 to form a continuous diversion channel. The steam jacket 259 is welded to the inner wall of the discharge cylinder 251, with a jacket thickness of 10 - 15 mm. Steam (temperature 80 - 120 °C) is introduced through the heating branch pipe 256 to preheat the solution in the cylinder. The spiral blade 258 is made of 304 stainless steel, with a pitch of 50 - 80 mm and a blade inclination angle of 30°. It is driven by the power output device 252 to rotate (rotation speed 50 - 100 rpm) to push the solution forward in a spiral. The power output device 252 integrates a planetary reducer and a transmission shaft, and is powered by the drive motor 253 to ensure the stable operation of the spiral blade.

[0059] The heparin sodium solution enters the discharge cylinder 251 through the crystallization output pump 225. Steam at 80 - 120 °C is introduced into the steam jacket 259, and the solution is preheated from 25 °C to 40 - 50 °C through heat conduction through the cylinder wall, reducing the subsequent drying energy consumption. The power output device 252 drives the spiral blade 258 to rotate, forming a vortex to push the solution to flow evenly, avoiding local overheating or deposition of crystal particles, and the flow rate is controlled at 0.5 - 1.2 m / s.

[0060] The drying turnover cylinder 254 includes a turnover cylinder body 2541 and a falling bin 2542 installed at the bottom of the turnover cylinder body 2541. A detector 255 is provided on the side edge of the falling bin 2542; the detector 255 includes a detection frame 2556 and a detection support frame 2553 installed on the detection frame 2556. A detection through pipe 2552 is provided at the detection end of the detection support frame 2553, and the detection through pipe 2552 is connected to the falling bin 2542 through an air flow support cylinder 2551. An air-driven support piece 2554 is provided on the detection support frame 2553, and the air-driven support piece 2554 is installed at the induction end of the detection support frame 2553 through an elastic induction end 2555.

[0061] The turnover cylinder body 2541 is flange-connected to the discharge cylinder 251, and is connected to the dryer 26 through the falling bin 2542 at the bottom to form a continuous drying channel 13. The falling bin 2542 is designed in a conical shape, with a polytetrafluoroethylene anti-sticking layer coated on the surface. The side edge is connected to the detection through pipe 2552 through the air flow support cylinder 2551 for monitoring the falling state of the material. The detection support frame 2553: is installed on the detection frame 2556, made of aluminum alloy, with a pressure sensor integrated inside, and the air pressure change in the falling bin 2542 is collected in real time through the detection through pipe 2552. The air-driven support piece 2554 is hinged inside the detection support frame 2553 and is linked with the air flow support cylinder 2551 through the elastic induction end 2555 to respond to the pressure fluctuation when the material is blocked or the flow rate is abnormal.

[0062] The preheated sodium heparin crystals enter the falling bin 2542 through the drying turnover cylinder 2541. During the falling process, air flow disturbance is generated. The air flow enters the detection through-tube 2552 through the air flow branch tube 2551, triggering the pressure sensor 23 in the detection support frame 2553. Under normal flow rate, the air flow pressure is stable (such as 0.5 - 2.0 kPa), and the pneumatic support piece 2554 remains horizontal; when the material is blocked, the pressure suddenly rises (≥5 kPa), and the elastic induction end 2555 deforms to push the pneumatic support piece 2554 to tilt, triggering an alarm signal. The pressure data of the detector 255 is transmitted to the control system of the dryer 26 in real time, automatically adjusting the drying temperature (±5 °C) or starting and stopping the conveyor pump to prevent material accumulation or equipment overload.

[0063] This embodiment is designed with anti-blocking protection. Based on the real-time regulation of the air flow pressure change and the linkage design of the pneumatic support piece 2554 and the elastic induction end 2555, the blockage detection response time ≤ 0.5 seconds, and the false alarm rate is less than 2%.

[0064] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic characteristics of the present invention. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be included in the present invention.

[0065] In addition, it should be understood that although this specification is described according to the embodiments, not every embodiment only contains an independent technical solution. This narrative way of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A crude heparin sodium impurity removal and purification device, comprising a system frame (1) and an impurity removal system and a purification system mounted on the system frame (1), characterized in that: The impurity removal system comprises an upper edge support (11), on which a preliminary screening chamber (13), a circulation guide chamber (14), a filtering device (15) and a crystallizer (16) are sequentially arranged, wherein: The preliminary screening chamber (13) is arranged at the feeding end of the impurity removal system, and is internally provided with a crushing assembly (12) consisting of double-layer staggered rotating crushing rollers; The circulation guide box (14) is provided with a hydraulically driven spiral guide plate; The filtering device (15) comprises an upper layer of transverse stainless steel filter wires and a lower layer of longitudinal ceramic filter wires; The crystallizer (16) is provided with a condensation module for gradient cooling; The purification system comprises a centrifugal separator (22), a preheating guide cylinder (25) and a dryer (26), wherein: The centrifugal separator (22) is connected to the crystallizer (16) via a purification introduction box (23), and its bottom is connected to a preheating guide tube (25) via a sodium heparin outlet tube (24); The preheating guide cylinder (25) has a steam jacket and spiral blades built in it, and the crystals are transported by spiral propulsion. The outlet end of the preheating guide cylinder (25) is connected to a dryer (26); The side edge of the dryer (26) is integrated with a vacuum extraction component (27).

2. The crude heparin sodium impurity removal and purification equipment according to claim 1, characterized in that: The preliminary screening chamber (13) is provided with an inlet and removal bucket (131), a dust outlet (132) at the bottom and a guide frame plate (133) at the top; the guide frame plate (133) is adjusted to an inclination angle of 25° by a hydraulic push rod, one end of the guide frame plate is butted against the receiving end (223), and the other end is guided to the roller gap of the crushing roller pair (122).

3. The crude heparin sodium impurity removal and purification equipment according to claim 2, characterized in that: The crushing roller pair (122) comprises two parallel crushing roller elements, each roller element being composed of a support plate (123) and a crushing roller body (124); the support plate (123) is connected to the inner wall of the preliminary screening chamber (13) via an annular positioning bolt group (125), and an elastic gasket is provided between the support plate (123) and the chamber wall; the roller shaft of the crushing roller body (124) is mounted on the support plate (123) via a support bearing (126).

4. The crude heparin sodium impurity removal and purification equipment according to claim 3, characterized in that: A plurality of crushing steel wires (127) are distributed in a circular array on the roller surface of the crushing roller body (124), and the steel wires are curved inward in an arc shape; a counterweight head (128) is welded to the end of the crushing steel wire (127), and the counterweight head (128) generates a centrifugal impact force when the roller body rotates, thereby triggering micro-vibration at the root of the steel wire.

5. The crude heparin sodium impurity removal and purification equipment according to claim 1, characterized in that: The crystallizer (16) comprises a mounting frame (161) and a crystallization chamber (162) mounted on the mounting frame (161); the mounting frame (161) and the crystallization chamber (162) form an integrated communication structure; the crystallization chamber (162) is connected to the filtering device (15) via an inlet (168).

6. The crude heparin sodium impurity removal and purification equipment according to claim 5, characterized in that: The condensation module comprises a condensation base plate (163), a cooling boss (165) and a cooling main frame (166); The condensation bottom plate (163) is provided with an output port (167) which is connected to the purification introduction box (23); The condensation bottom plate (163) of the crystallizer (16) is internally provided with a stainless steel cooling coil (164), and the coil is externally connected to an ethylene glycol aqueous solution circulation system; a flow guide bracket (1661) is vertically mounted on the surface of the cooling boss (165), and a condenser (1662) is fixed on the top of the flow guide bracket (1661); The condenser (1662) actively cools down to 0-10°C, and the guide groove of the guide bracket (1661) causes the solution to form a vortex.

7. The crude heparin sodium impurity removal and purification equipment according to claim 6, characterized in that: The centrifugal separator (22) comprises a centrifugal kettle (221) and a kettle bucket (222) arranged at the bottom of the centrifugal kettle (221); the top of the centrifugal kettle (221) is provided with an access end (223) connected to the purification introduction box (23); the bottom of the kettle bucket (222) is provided with a crystallization output pump (225); and the side edge of the centrifugal kettle (221) is externally connected to a solution output pipe (224).

8. The crude heparin sodium impurity removal and purification equipment according to claim 7, characterized in that: The main body of the preheating guide cylinder (25) is a lead-out cylinder (251), one end of the lead-out cylinder (251) is provided with a lead-out cylinder (251), the lead-out cylinder (251) is externally connected to a sodium heparin lead-out cylinder (24), the sodium heparin lead-out cylinder (24) is connected to a crystallization output pump (225), and the other end of the lead-out cylinder (251) is provided with a drying circulation cylinder (254), which is connected to a dryer (26); A steam jacket (259) is provided on the inner wall of the outlet tube (251), and a heat supply branch pipe (256) is externally connected to the outlet tube (251), and a gas supply end of the heat supply branch pipe (256) is connected to the steam jacket (259).

9. The crude heparin sodium impurity removal and purification equipment according to claim 8, characterized in that: The inner cavity of the outlet cylinder (251) is provided with a spiral piece (258), the cylinder end of the outlet cylinder (251) is provided with a supercharger (252) and a supercharger pump (253) for driving the supercharger (252), and the power output end of the supercharger (252) is connected to the spiral piece (258).

10. The crude heparin sodium impurity removal and purification equipment according to claim 9, characterized in that: The drying rotating drum (254) comprises a rotating drum body (2541) and a drop bin (2542) mounted on the bottom of the rotating drum body (2541); a detector (255) is arranged on the side edge of the drop bin (2542); the detector (255) comprises a detection frame (2556) and a detection support frame (2553) mounted on the detection frame (2556); a detection through pipe (2552) is arranged at the detection end of the detection support frame (2553); the detection through pipe (2552) is connected to the drop bin (2542) via an airflow support drum (2551); The detection support frame (2553) is provided with a pneumatic support piece (2554), and the pneumatic support piece (2554) is installed on the sensing end of the detection support frame (2553) via an elastic sensing end (2555).

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