Acne-removing composition, application thereof and daily chemical product

Abstract

The invention belongs to the field of daily chemical products, and particularly relates to an acne removing composition. The composition contains an antibacterial component and a stabilizer for preventing the antibacterial component from deteriorating, and the stabilizer contains hydrolyzed corn starch and trehalose. In the invention, the antibacterial component cinnamon bark extract contains volatile oil, the oil contains cinnamaldehyde, eugenol, tannin, phlegm and other components, the clove oil contains eugenol, caryophyllene, eugenol acetate and other components, and the components have the effects of inhibiting propionibacterium acnes and staphylococcus aureus and can play a synergistic acne removal effect. The stabilizer hydrolyzed corn starch and trehalose can play a synergistic role, so that the antibacterial components are effectively prevented from being oxidized and discolored, the stability is improved, and the service life is prolonged. The invention further discloses application and daily chemical products of the composition.

Description

Technical Field

[0001] The present invention belongs to the field of daily chemical products, and particularly relates to an acne-removing composition, its application, and cosmetics. Background Art

[0002] Acne, commonly known as adolescent acne, acne vulgaris, and acne, was called facial sores and wine thorns in ancient Chinese medicine. It is a common and frequently-occurring disease in dermatology. According to scholars' statistics, 95% of males and 85% of females in adolescence have suffered from acne to varying degrees, so it is very appropriate to call it "adolescent acne". Acne (adolescent acne) is a chronic skin disease that occurs in hair follicles and sebaceous glands, and mostly occurs in areas rich in sebaceous glands such as the head, face, neck, chest, and back. The main causes of acne are: increased sebum secretion, blocked pores, overgrowth of Propionibacterium acnes, and skin inflammation.

[0003] In the prior art, most acne-removing compositions use plant extracts as the main ingredients and achieve acne removal by controlling oil and inhibiting bacteria. Although there are many acne-removing composition products on the market at present, the acne-removing efficacy of most acne-removing compositions is not high, and there will also be problems of flavor and color change when applied to products, especially the plant acne-removing ingredients in the composition.

[0004] Therefore, the technical problem to be solved in this case is: how to develop an acne-removing composition with high acne-removing efficacy and no color or flavor change during the application process. Summary of the Invention

[0005] The purpose of the present invention is to provide an acne-removing composition, which contains an antibacterial component, cinnamon bark extract and / or clove oil, as well as hydrolyzed corn starch and trehalose. The polyhydroxy structure in hydrolyzed corn starch and trehalose has a protective effect on cinnamon bark extract and clove oil, preventing them from being oxidized and yellowed, making the acne-removing composition extremely stable.

[0006] At the same time, the present invention also provides the application of this acne-removing composition.

[0007] To achieve the purpose of this invention, the following technical solutions are adopted:

[0008] An acne-removing composition, the acne-removing composition contains an antibacterial component and a stabilizer to prevent the antibacterial component from deteriorating, and the stabilizer contains hydrolyzed corn starch and trehalose.

[0009] In the present invention, the antibacterial component cinnamon bark extract contains volatile oil, and the oil contains components such as cinnamaldehyde, eugenol, tannin, and mucilage. Clove oil contains components such as eugenol, caryophyllene, and eugenol acetate. These components have the effect of inhibiting Propionibacterium acnes and Staphylococcus aureus, and can play the role of treating acne. However, these components are easily oxidized and discolored, resulting in poor product stability and short service life. Through a large number of studies in the present invention, it is found that adding hydrolyzed corn starch and trehalose can effectively prevent the oxidation and discoloration of antibacterial components, increase stability, and the mechanism is as follows:

[0010] Hydrolyzed corn starch can provide hydrogen atoms. In the process of oxidation reaction, free radicals are the key factors causing oxidation. These free radicals have unpaired electrons and very active chemical properties. The hydroxyl groups (-OH) in the molecular structure of hydrolyzed corn starch can react with free radicals. By providing hydrogen atoms, the free radicals are turned into relatively stable molecules, thus interrupting the free radical chain reaction. And the hydroxyl groups have a certain reducing property and can react with peroxides, being oxidized themselves while the peroxides are reduced, thereby preventing further oxidation and deterioration of emulsifiers, etc. Multiple hydroxyl groups of trehalose can form hydrogen bonds with multiple phenolic hydroxyl groups and aldehyde groups, thus constructing a relatively stable protective film. This film can block the direct contact of oxygen, free radicals, and other harmful chemical substances with skin cells, reduce the oxidation rate of skin cells, and thus play an antioxidant role.

[0011] In some other studies of the present invention, it is found that when hydrolyzed corn starch and trehalose are used simultaneously, there is a synergistic effect, further increasing the protection effect on antibacterial components and greatly improving the stability of the acne treatment composition.

[0012] Preferably, the weight ratio of hydrolyzed corn starch to trehalose in the stabilizer is 0.1 - 2:0.1 - 2.

[0013] Preferably, the weight ratio of the antibacterial component to the stabilizer in the acne treatment composition is 0.2 - 4:0.2 - 4.

[0014] Preferably, the antibacterial component is cinnamon bark extract and / or clove oil.

[0015] More preferably, the weight ratio of cinnamon bark extract to clove oil in the antibacterial component is 0.1 - 2:0.1 - 2.

[0016] In addition, the present invention also discloses the use of the above-mentioned acne treatment composition in preparing daily chemical products.

[0017] Preferably, the daily chemical product is a daily chemical product for treating acne.

[0018] Finally, the present invention also provides a daily chemical product containing the acne-removing composition as described above. The content of the acne-removing composition in the daily chemical product is 0.4 wt% to 50 wt%, preferably 0.4 wt% to 20 wt%, and more preferably 0.4 wt% to 8 wt%.

[0019] Preferably, the daily chemical product further contains a soothing agent, a surfactant, a preservative, a chelating agent, a humectant, an inorganic salt, a fragrance, a pH regulator, and water;

[0020] The soothing agent is one or a combination of more of copper tripeptide-1, palmitoyl tripeptide-8, panthenol, squalane, and hyaluronic acid;

[0021] The surfactant is one or a combination of more of sodium lauryl polyether sulfate, coconut oil amide propyl hydroxysulfobetaine, coconut oil amide methyl MEA, and sodium cocoyl aminopropionate;

[0022] The preservative is one or a combination of more of phenoxyethanol and ethylhexylglycerin, and dichlorobenzyl alcohol.

[0023] Preferably, the daily chemical product includes body wash, spray, lotion, cream, lotion, and essence.

[0024] Compared with the prior art, the beneficial effects of this case are as follows:

[0025] In the present invention, the antibacterial component cinnamon bark extract contains volatile oil, and the oil contains components such as cinnamaldehyde, eugenol, tannins, and mucilage. Clove oil contains components such as eugenol, caryophyllene, and eugenol acetate. These components have the effect of inhibiting Propionibacterium acnes and Staphylococcus aureus, and can play a synergistic acne-removing effect. The stabilizers hydrolyzed corn starch and trehalose can play a synergistic role, effectively preventing the oxidation and discoloration of the antibacterial components, increasing stability, and extending the service life. Specific Embodiments

[0026] The following combines examples to further describe the present invention, but does not constitute any limitation to the present invention. Any limited modifications made within the scope of the claims of the present invention are still within the scope of the claims of the present invention.

[0027] In order to illustrate the technical content of the present invention in detail, the following further explains in combination with the embodiments.

[0028] Reagent source information:

[0029] Cinnamon bark extract: Foshan Green Extract Source Biotechnology Co., Ltd., raw material model cinnamon bark extract;

[0030] Clove oil: Jiangxi Yisenyuan Plant Spice Co., Ltd., raw material model is clove oil;

[0031] Copper Tripeptide-1: Dongguan Vicky Technology Co., Ltd., raw material model number is Copper peptide X;

[0032] Hydrolyzed corn starch: Hangzhou Xiwang Biotechnology Co., Ltd., raw material model number is JY-10 maltotetraose;

[0033] Trehalose: Tongliao Meihua Biotechnology Co., Ltd., raw material model number is crystalline trehalose ViviSugar THS.

[0034] Example

[0035] A body wash, whose formula refers to Table 1

[0036] Table 1: Formula table

[0037]

[0038] The preparation method of the body wash is as follows:

[0039] Step 1: First add deionized water, disodium EDTA, sodium lauryl polyether sulfate, cocamidopropyl hydroxysultaine, cocamide MEA, sodium cocoyl aminopropionate, and stir until completely dissolved;

[0040] Step 2: Add the acne-combating composition, PE9010 (phenoxyethanol and ethylhexylglycerin), fragrance and dichlorobenzyl alcohol pretreatment solution, and stir until completely dissolved;

[0041] Step 3: Add citric acid to adjust the pH value (10%) to 5.0 - 6.5, and add sodium chloride to adjust the viscosity.

[0042] The specific components of the composition described in Table 1 can be specifically referred to Table 2. Table 2: Formula table

[0043] Cinnamon bark extract Clove oil Hydrolyzed corn starch Trehalose Composition 1 0.5 0.5 1 1 Composition 2 0.1 2 0.1 2 Composition 3 2 0.1 2 0.1 Composition 4 1 0 1 1 Composition 5 0 1 1 1 Composition 6 0.5 0.5 2 0 Composition 7 0.5 0.5 0 2 Composition 8 0.5 0.5 Hydrolyzed cassava starch / 1 1 Composition 9 0.5 0.5 Hydrolyzed potato starch / 1 1 Composition 10 0.5 0.5 1 Xylan / 1 Composition 11 0.5 0.5 1 Glucan / 1 Composition 12 0.5 0.5 0 0

[0044] Antibacterial test against Propionibacterium acnes: The test method and basis are QB / T 2738-2023 7.3

[0045] 1. Culture media: Nutrient agar medium, BHIA medium.

[0046] 2. Instruments used: Biological safety cabinet, low-temperature constant temperature bath, biochemical incubator, anaerobic incubator, electronic balance JJ500, electronic balance JJ523BC.

[0047] Perform antibacterial tests on compositions 1 - 12 against Propionibacterium acnes, and the test results are shown in Table 3;

[0048] Table 3 Antibacterial results against Propionibacterium acnes

[0049]

[0050] After using different compositions in body wash, body washes 1 to 12 were obtained.

[0051] The composition corresponding to body wash 1 is composition 1, and so on. The composition corresponding to body wash 12 is composition 12.

[0052] Performance test

[0053] 1. Stability test: The body washes prepared above were placed at normal temperature, 48 °C, -18 °C, and 5 °C for 3 months respectively, and the properties of the samples under each condition before and after storage were checked. The test results are shown in Table 3.

[0054] Table 3 Results of stability test

[0055]

[0056]

[0057] Under each test condition, the odor of the above body washes did not change significantly.

[0058] 2. Usage experience test: 60 subjects, aged 18 - 55 years old, with 5 subjects in each group, used body washes 1 to 12 above respectively. After using the products continuously for 14 days, they were evaluated in the form of scoring. The evaluation indicators were: 1 point for "very disagree", 2 points for "agree", 3 points for "average", 4 points for "agree", and 5 points for "very agree". The evaluation results of the subjects for the samples were collected, and the results are shown in Table 4 for reference.

[0059] Table 4 Statistics of the number of people with each evaluation indicator ≥ 4 points after use

[0060]

[0061]

[0062] Result analysis: After testing, for the sample stock solution, with an action time of 5 minutes, the antibacterial rates of compositions 1 - 3, 6 - 12 against Propionibacterium acnes were > 99.97%. Compositions 1 - 3, 6 - 12 contain cinnamon bark extract, and the volatile oil it contains has components such as cinnamaldehyde, eugenol, tannins, and mucilage. Clove oil contains components such as eugenol, caryophyllene, and eugenol acetate. These components have the effect of inhibiting Propionibacterium acnes and Staphylococcus aureus and can play an acne - removing effect. By comparing the data of compositions 1, 4, and 5, it can be known that the composition must contain both cinnamon bark extract and clove oil at the same time to achieve an efficient synergistic acne - removing effect.

[0063] However, it was found in the research of the present invention that when the composition only contains cinnamon bark extract and clove oil, although it has good effects in treating acne, the shelf life of the shower gel prepared therefrom is relatively short, and it will deteriorate and change color in a short time, which has a great impact on the product quality.

[0064] Through the research of the technical personnel of the present invention, it was found that adding hydrolyzed corn starch and trehalose to the composition can effectively solve the above-mentioned deterioration problem. It can be seen from the data in Table 3 that when comparing Shower Gel 1 with Shower Gels 6-12:

[0065] When either hydrolyzed corn starch or trehalose is missing in Shower Gels 6 and 7, after being placed at room temperature for 3 months, the color turns light yellow, and after being placed at 48 °C for 3 months, the color turns dark yellow;

[0066] In Shower Gels 8, 9, 10, and 11, hydrolyzed corn starch was replaced with hydrolyzed cassava starch and hydrolyzed potato starch with the same shelf-life effect, and trehalose was replaced with xylan and dextran, and their color changes were the same as those of Shower Gels 6 and 7;

[0067] Shower Gel 12 is a case without adding hydrolyzed corn starch and trehalose, and it deteriorates most severely after being placed at room temperature, 48 °C, -18 °C, and 5 °C for 3 months, and its appearance turns dark yellow, dark brown, dark yellow, and dark yellow respectively;

[0068] From the above cases, it can be concluded that hydrolyzed corn starch and trehalose must be used simultaneously to have a strong synergistic effect and exert the best shelf-life effect. And through the human perception test, it can be known that the application of Composition 1 in the shower gel has the best acne treatment effect.

[0069] The cinnamon bark extract in the solution of the present invention contains volatile oil, and the oil contains components such as cinnamaldehyde, eugenol, tannin, and mucilage. Clove oil contains components such as eugenol, caryophyllene, and eugenol acetate. These components have the effect of inhibiting Propionibacterium acnes and can play an acne treatment effect. However, these components are easily oxidized and discolored. This patent combines hydrolyzed corn starch and trehalose with polyhydroxy structural components, which have a protective effect on cinnamon bark extract and clove oil, preventing them from being oxidized and turning yellow. Further, it is combined with copper tripeptide-1, which not only enhances the protective effect on the active ingredients, but also has a soothing effect itself, further improving the efficacy performance of the product.

[0070] The embodiments presented herein are only selected embodiments according to all possible combinations of embodiments. The appended claims should not be limited by the embodiments illustrating the present invention. Some numerical ranges used in the claims include sub-ranges within them, and variations within these ranges should also be covered by the appended claims.

Claims

1. An anti-acne composition, characterized in that, The acne-removing composition described above contains an antibacterial component and a stabilizer for preventing the deterioration of the antibacterial component, and the stabilizer contains hydrolyzed corn starch and trehalose.

2. The anti-acne composition according to claim 1, characterized in that The weight ratio of hydrolyzed corn starch to trehalose in the stabilizer is 0.1 - 2:0.1 - 2.

3. The acne-removing composition according to claim 1, wherein The weight ratio of the antibacterial component to the stabilizer in the acne-removing composition is 0.2 - 4:0.2 - 4.

4. The anti-acne composition according to claim 1, wherein The antibacterial component is cinnamon bark extract and / or clove oil.

5. The anti-acne composition according to claim 4, characterized in that, The weight ratio of cinnamon bark extract to clove oil in the antibacterial component is 0.1 - 2:0.1 - 2.

6. Use of the acne-removing composition according to any one of claims 1 - 5 for preparing a daily chemical product.

7. The use according to claim 6, characterized in that, The daily chemical product is a daily chemical product for removing acne.

8. A daily chemical product, characterized in that, Containing the acne-removing composition according to any one of claims 1 - 5, and the content of the acne-removing composition in the daily chemical product is 0.4wt% - 50wt%.

9. The daily chemical product according to claim 8, wherein The content of the acne-removing composition in the daily chemical product is 0.4wt% - 8wt%.

10. The daily chemical product according to claim 9, wherein The daily chemical product includes body wash, spray, lotion, cream, lotion, essence.

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