External ointment for treating acute and subacute tendon injury bone diseases and preparation method thereof

Abstract

The invention discloses an external ointment for treating acute and subacute tendon injury bone diseases and a preparation method thereof, and the external ointment comprises the following components in parts by weight: 4 parts of frankincense, 4 parts of myrrh, 4 parts of dragon's blood, 3 parts of safflower, 3 parts of rhizoma drynariae, 3 parts of dipsacus root, 4 parts of pseudo-ginseng powder, 4 parts of indigo naturalis and 4 parts of ground beeltle. According to the external ointment, the frankincense, the myrrh, the dragon's blood, the safflower, the rhizoma drynariae, the dipsacus root, the pseudo-ginseng powder, the indigo naturalis, the ground beetle and other components are combined, so that the symptoms such as acute and subacute tendon injury and bone diseases can be effectively treated, the problems existing in the prior art in which western medicine is adopted for treating the symptoms are solved, and the external ointment can achieve the effects of activating blood to promote menstruation, dissipating blood stasis to relieve pain and relieving pain. The traditional Chinese medicine has the effects of dispelling wind, eliminating dampness, warming channels, expelling cold, tonifying liver and kidney, strengthening tendons and bones and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of ointment formulations, and specifically refers to an external ointment for treating acute and subacute tendon and bone injuries and its preparation method. Background Art

[0002] The correct treatment and handling of acute and subacute stages of tendon and bone injuries determine the course and prognosis of the injuries. Clinically, the early treatment of tendon and bone injuries mainly relies on Western medicine, but the medication time is long, the curative effect is not obvious, some drugs are highly toxic, and they are extremely likely to damage the spleen, stomach, liver and kidneys, and it is very difficult to achieve a radical cure. Some will relapse soon after stopping the medication. Some also adopt surgical treatment combined with taking medicine, but the surgical treatment is expensive, and there are many sequelae and complications left by the surgery, and it is also easy to relapse after the operation. Although traditional Chinese medicine has a long history of treating orthopedic diseases and has achieved good treatment effects, currently, traditional Chinese medicine mostly uses bone-setting reduction or traction methods for the above-mentioned diseases, which requires correct manipulation by doctors. If the operation is improper, it is very easy to cause secondary pain to patients.

[0003] In addition to the above methods, in the prior art, Western medicines are used to treat acute and subacute tendon and bone injuries. After taking Western medicines, side effects will occur, the symptoms of patients cannot be radically cured, the recovery process is slow, and recurrence and other phenomena will occur after treatment. In the ancient records and the empirically effective prescriptions inherited from generation to generation among the people, the early intervention of traditional Chinese medicine external medicines for acute and subacute tendon and bone injuries can greatly accelerate the recovery, shorten the course of disease, and improve the prognosis. Using a special combination of traditional Chinese medicines such as dragon's blood, ground beetle, and drynaria rhizome, it plays the role of reconnecting tendons and bones, promoting blood circulation and reducing swelling, and with a special preparation method, its efficacy is amplified, and the transdermal degree and utilization rate are improved; clinical practice has proved that it has good clinical efficacy and safety.

[0004] Therefore, an external ointment for treating acute and subacute tendon and bone injuries and its preparation method have become an urgent problem to be solved in the whole society. Summary of the Invention

[0005] To solve the above technical problems, the technical solution provided by the present invention is: an external ointment for treating acute and subacute tendon and bone injuries and its preparation method. The external ointment includes the following weight components: 4 parts of frankincense, 4 parts of myrrh, 4 parts of dragon's blood, 3 parts of safflower, 3 parts of drynaria rhizome, 3 parts of eucommia ulmoides, 4 parts of notoginseng powder, 4 parts of indigo naturalis, and 4 parts of ground beetle.

[0006] Further, the external ointment includes the following weight components: 4g of frankincense, 4g of myrrh, 4g of dragon's blood, 3g of safflower, 3g of drynaria rhizome, 3g of eucommia ulmoides, 4g of notoginseng powder, 4g of indigo naturalis, and 4g of ground beetle.

[0007] Further, the external ointment includes the following components by weight: 8g of frankincense, 8g of myrrh, 8g of blood clotting, 6g of safflower, 6g of drynaria, 6g of chuanduan, 8g of panax notoginseng powder, 8g of indigo and 8g of earthworm.

[0008] Further, the external ointment includes the following components by weight: 12g of frankincense, 12g of myrrh, 12g of blood clotting, 9g of safflower, 9g of drynaria, 9g of chuanxiong, 12g of Panax notoginseng powder, 12g of indigo and 12g of earthworm.

[0009] The advantages of the invention compared with the prior art are: The invention adopts a combination of multiple ingredients such as frankincense, myrrh, dragon's blood, safflower, drynaria, chuanxiong, notoginseng powder, indigo and earthworm, etc., can effectively treat symptoms of acute and subacute tendon injury and bone disease, solves the problem of using western medicine to treat the above symptoms in the prior art, and the external ointment can achieve the effects of promoting blood circulation and menstruation, dispersing blood stasis and relieving pain, dispelling wind and dampness, warming the meridians and dispersing cold, and nourishing the liver and kidney, strengthening tendons and bones.

[0010] The compound Xuejie Dieda plaster of the present invention has a complex taste, the main components of the resin drugs such as frankincense and myrrh in the prescription are oily, the extracts of safflower, chuanxiong and the like are water-soluble, and preliminary experiments have found that the emulsion matrix can better dissolve and disperse the raw material drugs. The ointment prepared by the present invention is uniform and fine, easy to apply, and has stable quality, and the fingerprint spectrum results show that the preparation process is stable and feasible.

[0011] The basic principle of the transdermal external therapy represented by the plaster of the present invention is to use drugs, applied to the surface of the patient's body, and use the three aspects of meridian conduction, skin penetration and mucosal absorption to play the role of drugs in clearing the meridians, removing blood stasis, opening the orifices and penetrating the bones, and expelling wind and dispersing evil to achieve the purpose of treating diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 It is HPLC fingerprint. DETAILED DESCRIPTION

[0013] The present invention is further described in detail below.

[0014] The present invention is described in detail.

[0015] The present invention provides an external ointment for treating acute and subacute tendon and bone injuries and a preparation method thereof during specific implementation. The external ointment comprises the following components by weight: 4 parts of frankincense, 4 parts of myrrh, 4 parts of dragon's blood, 3 parts of safflower, 3 parts of drynaria, 3 parts of chuanxiong, 4 parts of notoginseng powder, 4 parts of indigo and 4 parts of earthworm. Example

[0016] An external-use ointment for treating acute and subacute muscle and bone injuries, the external-use ointment comprising the following components by weight: 4 g of frankincense, 4 g of myrrh, 4 g of dragon's blood, 3 g of safflower, 3 g of drynaria rhizome, 3 g of Dipsacus asperoides, 4 g of notoginseng powder, 4 g of indigo naturalis, and 4 g of ground beetle.

[0017] An external-use ointment for treating acute and subacute muscle and bone injuries and a preparation method thereof, comprising the following method steps: (1) Prepare raw materials according to the above components by weight; (2) Grind the medicinal materials into powder, mix them evenly, and then add honey to adjust to a paste, and apply the obtained paste to the affected area; (3) During the application of the ointment in step (2), rub it in cooperation to promote the absorption of the ointment; (4) Then perform dressing and fixation to prevent the drug from oozing out. Example

[0018] The external-use ointment comprises the following components by weight: 8 g of frankincense, 8 g of myrrh, 8 g of dragon's blood, 6 g of safflower, 6 g of drynaria rhizome, 6 g of Dipsacus asperoides, 8 g of notoginseng powder, 8 g of indigo naturalis, and 8 g of ground beetle.

[0019] An external-use ointment for treating acute and subacute muscle and bone injuries and a preparation method thereof, comprising the following method steps: (1) Prepare raw materials according to the above components by weight; (2) Grind the medicinal materials into powder, mix them evenly, and then add honey to adjust to a paste, and apply the obtained paste to the affected area; (3) During the application of the ointment in step (2), rub it in cooperation to promote the absorption of the ointment; (4) Then perform dressing and fixation to prevent the drug from oozing out. Example

[0020] An external-use ointment for treating acute and subacute muscle and bone injuries, the external-use ointment comprising the following components by weight: 12 g of frankincense, 12 g of myrrh, 12 g of dragon's blood, 9 g of safflower, 9 g of drynaria rhizome, 9 g of Dipsacus asperoides, 12 g of notoginseng powder, 12 g of indigo naturalis, and 12 g of ground beetle.

[0021] An external-use ointment for treating acute and subacute muscle and bone injuries and a preparation method thereof, comprising the following method steps: (1) Prepare raw materials according to the above components by weight; (2) Grind the medicinal materials into powder, mix them evenly, and then add honey to adjust to a paste, and apply the obtained paste to the affected area; (3) During the application of the ointment in step (2), rub it in cooperation to promote the absorption of the ointment; (4) Then perform dressing and fixation to prevent the drug from oozing out.

[0022] As a further illustration of the present invention, the powder particle size is 100 mesh.

[0023] As a further elaboration of the present invention, the external application time of the ointment does not exceed 6 hours.

[0024] 2. The method for obtaining the fingerprint spectrum experiment is as follows: 2.2.1 Chromatographic conditions Agilent ZORBAXSB-C18 chromatographic column (4.6×250mm, 5µm); mobile phase water (A)-acetonitrile (B) gradient elution conditions are shown in Table 7; detection wavelength is 283nm; injection volume is 10µL; column temperature is 40℃; flow rate is 1.0mL·min-1.

[0025] 2.2.2 Preparation of test samples Weigh 5 g of ointment, add 30 mL of methanol and extract by ultrasonic (250 W, frequency 40 KHz) for 30 min. After cooling, filter and pass the filtrate through a 0.22 µm microporous filter membrane to obtain the product.

[0026] 2.2.3 Establishment of HPLC fingerprint (1) Methodological investigation The results of the precision experiment showed that when the sample (0519) was taken to prepare 1 test solution, 6 injections were made continuously, and the highest peak was used as a reference. The relative retention time RSD of the common peak with a peak area greater than 80,000 was <0.62%, and the relative peak area RSD was <4.84%, indicating that the instrument had good precision. The results of the repeatability experiment showed that when the sample (0519) was taken to prepare 6 test solutions in parallel, and the highest peak was used as a reference, the relative retention time RSD of the common peak was <0.15%, and the relative peak area RSD was <4.62%, indicating that the method had good repeatability. The results of the stability experiment showed that when the sample (0519) was taken to prepare 1 test solution, and the samples were injected at 0, 6, 12, 18, and 24 hours, respectively. The highest peak was used as a reference, and the relative retention time RSD of the common peak was <0.47%, and the relative peak area RSD was <4.84%, indicating that the instrument had good precision. The area RSD was <4.17%, indicating that the test solution was basically stable within 24 h.

[0027] (2) Graph generation Take 11 batches of samples, prepare the test solution according to the method in 3.2.2, and test according to the chromatographic conditions in 2.2.1. Save the processed results in cdf format and import them into the "Chinese Herbal Chromatographic Fingerprint Similarity Evaluation System 2012". 19 common peaks are obtained, and the similarities are all >0.9. The peaks are assigned as follows Figure 1 shown.

[0028] The product prepared in this experiment is uniform and fine, easy to apply and has stable quality. The fingerprint results show that the preparation process is stable and feasible.

[0029] The above describes the present invention and its implementation manners, and such description is not restrictive. Generally speaking, if those of ordinary skill in the art are inspired by it and, without departing from the gist of the present invention, creatively design structural manners and embodiments similar to the technical solution, they shall fall within the protection scope of the present invention.

Claims

1. An external-use ointment for treating acute and subacute muscle and bone injuries, characterized in that: The external-use ointment comprises the following components by weight: 4 parts of frankincense, 4 parts of myrrh, 4 parts of dragon's blood, 3 parts of safflower, 3 parts of drynaria rhizome, 3 parts of eucommia bark, 4 parts of notoginseng powder, 4 parts of indigo naturalis, and 4 parts of ground beetle.

2. The external ointment for treating acute and subacute tendon and bone injuries according to claim 1, characterized in that: The external-use ointment comprises the following components by weight: 4 g of frankincense, 4 g of myrrh, 4 g of dragon's blood, 3 g of safflower, 3 g of drynaria rhizome, 3 g of eucommia bark, 4 g of notoginseng powder, 4 g of indigo naturalis, and 4 g of ground beetle.

3. An external ointment for treating acute and subacute tendon and bone injuries according to claim 1, characterized in that: The external-use ointment comprises the following components by weight: 8 g of frankincense, 8 g of myrrh, 8 g of dragon's blood, 6 g of safflower, 6 g of drynaria rhizome, 6 g of eucommia bark, 8 g of notoginseng powder, 8 g of indigo naturalis, and 8 g of ground beetle.

4. An external ointment for treating acute and subacute muscle and bone injuries according to claim 1, characterized in that: The external-use ointment comprises the following components by weight: 12 g of frankincense, 12 g of myrrh, 12 g of dragon's blood, 9 g of safflower, 9 g of drynaria rhizome, 9 g of eucommia bark, 12 g of notoginseng powder, 12 g of indigo naturalis, and 12 g of ground beetle.

5. The external ointment for treating acute and subacute tendon and bone injuries and its preparation method according to claim 1, characterized in that: It includes the following method steps: (1) Prepare the raw materials according to the above weight components. (2) Grind the medicinal materials into powder, mix them evenly, and then add honey to make a paste, and apply it to the affected area. (3) During the application of the ointment in step (2), rub it to promote the absorption of the ointment. (4) Then bandage and fix it to prevent the drug from oozing out.

6. The external-use ointment for treating acute and subacute tendon and bone injuries and its preparation method according to claim 5, characterized in that: The particle size of the powder is 100 mesh.

7. An external ointment for treating acute and subacute muscle and bone injuries and its preparation method according to claim 5, characterized in that: The external application time of the ointment does not exceed 6 hours.

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