Photosensitizer based on 1, 8-naphthalimide and phototherapy application thereof
By optimizing the synthesis path of 1,8-naphthalene lactimide photosensitizer, the problems of insufficient light penetration depth and poor water solubility are solved, efficient reactive oxygen production and tumor targeting are achieved, and the effect of photodynamic therapy is improved.
Patent Information
- Application Number
- CN202510383504.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-28
- Publication Date
- 2025-07-04
- Estimated Expiration
- 2045-03-28
AI Technical Summary
In photodynamic therapy, existing 1,8-naphthalene lactimide photosensitizers have problems such as insufficient light penetration depth, poor tumor tissue targeting and low singlet oxygen quantum yield, and some compounds have poor water solubility, which affects their transmission and distribution in biological bodies.
By synthesizing a photosensitizer based on 1,8-naphthalene lactimide, using specific synthesis pathways and reaction conditions, including the use of phosphorus oxychloride and boron trifluoride ether complex for fluoroboration, the compounds Np-BOP, Np-OMe and Np-OEt were obtained, and the feed sequence and proportion were optimized to ensure that the reaction was complete and there were few side reactions.
The photosensitizer is able to efficiently produce reactive oxygen species under specific wavelengths of light, showing significant phototoxicity and selective accumulation of tumor cells, improving the safety and selectivity of phototherapy, having good photostability and modifyability, and is suitable for tumor targeted treatment.