Pancreas-eliminating traditional Chinese medicine preparation for treating diabetes and preparation method thereof

Abstract

The invention discloses a pancreas-eliminating traditional Chinese medicine preparation for treating diabetes mellitus, which is prepared from the following components in parts by weight: 8 to 20 parts of bitter gourd extract, 6 to 20 parts of rhizoma atractylodis, 8 to 20 parts of rhizoma atractylodis macrocephalae, 10 to 25 parts of poria cocos, 10 to 25 parts of ramuli euonymi and 10 to 25 parts of fried semen raphani. The traditional Chinese medicine can effectively reduce blood sugar and improve chronic complications caused by diabetes mellitus, and effective components in the medicinal materials have a synergistic effect, so that the effect of treating diabetes mellitus can be more comprehensively exerted; according to the method, effective components such as bitter gourd, ferulic acid and chlorophyll are extracted by using a supercritical fluid extraction technology, the extraction efficiency can be improved, the stability and biological activity of the active components can be maintained, and compared with a traditional decoction method, the effective components in the medicinal materials can be more efficiently extracted by using technologies such as ultrasonic-assisted extraction or hydrothermal extraction; the dissolution of harmful substances is reduced, and the safety and curative effect of the preparation are improved.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of a pancreas-eliminating Chinese medicinal preparation, in particular to a pancreas-eliminating Chinese medicinal preparation for treating diabetes and a preparation method thereof. Background Art

[0002] Diabetes mellitus is a group of metabolic diseases characterized by a gradual increase in blood glucose, pancreatic cell damage, and a relative and absolute decrease in insulin secretion.

[0003] The current treatment status of this type of disease. Diabetes is a disease with diverse causes and complex pathological formation. The current understanding of the causes and pathological factors includes genetic factors, acquired environmental factors, such as rubella virus, mumps virus, etc., damage to the glands, rodenticides and tumor suppressor drugs, etc.

[0004] The pathological formation is also diverse and complex, including sugar degradation disorders, carbohydrate-protein metabolism disorders, relative and absolute reductions in insulin secretion, etc.

[0005] Traditional diabetes treatments mostly use a single drug or a single herbal medicine. Although it can have a certain blood sugar-lowering effect, it often cannot comprehensively regulate the multiple pathological mechanisms of diabetes (such as insulin resistance, pancreatic β-cell dysfunction, etc.). In addition, traditional treatments usually lack the prevention and treatment of diabetic complications, and some drugs may be accompanied by side effects, such as hypoglycemia. Many traditional Chinese medicine preparations still use decoction to extract the active ingredients of medicinal materials, which may reduce the effectiveness of the drug ingredients and even produce harmful substances. In addition, the extraction efficiency of the decoction method is relatively low, and it is not easy to maintain the stability of the active ingredients in Chinese medicinal materials. Traditional diabetes treatment often requires patients to take multiple drugs, which makes medication complicated, increases the burden on patients, and even affects patient compliance. For this reason, we propose a pancreas-eliminating Chinese medicine preparation for the treatment of diabetes and its preparation method. Summary of the invention

[0006] The object of the present invention is to provide a pancreas-eliminating Chinese medicine preparation for treating diabetes and a preparation method thereof, so as to solve the problems raised in the above-mentioned background technology.

[0007] To achieve the above purpose, a pancreatic-eliminating Chinese medicine preparation for treating diabetes comprises, by weight, 8-20 parts of bitter melon extract, 6-20 parts of atractylodes, 8-20 parts of white atractylodes, 10-25 parts of tuckahoe, 10-25 parts of radix phellodendri, 10-25 parts of stir-fried radish seeds, 8-20 parts of plantain seeds, 8-20 parts of capillaris, 7-22 parts of anemarrhena, 3-15 parts of scutellaria, 10-25 parts of polygonum cuspidatum, 8-25 parts of salvia miltiorrhiza, 6-22 parts of safflower, 3-10 parts of tripterygium wilfordii glycosides and 2-10 parts of quercetin.

[0008] Preferably, it further includes 2 - 8 parts of ferulic acid and 1 - 6 parts of chlorophyll.

[0009] Preferably, it further includes 0.5 - 5 parts of probiotics and 2 - 10 parts of inulin.

[0010] Preferably, the balsam pear extract, ferulic acid and chlorophyll are prepared by cutting, drying, extracting, concentrating and drying the cleaned fresh balsam pear, ferulic acid and chlorophyll respectively.

[0011] According to the preparation method of a traditional Chinese medicine preparation for treating diabetes according to any one of the above, it includes the following steps:

[0012] S1. Wash the fresh and high-quality atractylodes rhizome, bighead atractylodes rhizome, poria cocos, winged euonymus, stir-fried radish seed, plantain seed, artemisia capillaris, anemarrhena asphodeloides, rhubarb, polygonum cuspidatum, salvia miltiorrhiza, safflower, tripterygium glycosides, quercetin and ferulic acid, cut them into small pieces and grind them into powder, and extract the balsam pear extract, ferulic acid and chlorophyll by supercritical fluid extraction;

[0013] S2. Slightly stir-fry the stir-fried radish seed and winged euonymus, place the atractylodes rhizome, bighead atractylodes rhizome, poria cocos, winged euonymus, stir-fried radish seed, plantain seed, artemisia capillaris, anemarrhena asphodeloides, rhubarb, polygonum cuspidatum, salvia miltiorrhiza, safflower, tripterygium glycosides, quercetin and ferulic acid in a casserole according to the formula ratio, add an appropriate amount of water, first boil it with high heat, and then change to low heat for decocting, and collect the extract in portions;

[0014] S3. Add the balsam pear extract, ferulic acid and chlorophyll to the decoction, and use ultrasonic-assisted extraction or hydrothermal extraction method to heat and extract the medicinal materials;

[0015] S4. Filter the decocted extract to remove impurities, concentrate the filtered extract, and further dehydrate the concentrated liquid to form a traditional Chinese medicine concentrated powder;

[0016] S5. Fill the concentrated powder into capsules, and each capsule can be adjusted as needed. Convert the concentrated liquid into granules by spray drying technology, or further process the concentrated liquid into oral liquid;

[0017] S6. After the traditional Chinese medicine preparation is completed, carry out appropriate packaging. For granules or capsules, use aluminum foil packaging, and the oral liquid should be stored in a cool and dry place.

[0018] Preferably, the amount of water added to the casserole in step S2 is eight times the amount of the medicinal materials.

[0019] Preferably, the time for low-heat decocting the medicinal materials in step S2 is 45 - 70 minutes.

[0020] Compared with the prior art, the beneficial effects of the present invention are:

[0021] 1. The present invention comprises a variety of Chinese medicinal ingredients (such as bitter melon extract, Poria cocos, Atractylodes macrocephala, Anemarrhena asphodeloides, etc.) that have the effects of regulating blood sugar, lowering blood sugar, protecting pancreatic islets, and improving complications of diabetes. The ingredients such as momordica charantia contained in the bitter melon extract can help lower blood sugar levels. Poria cocos, Atractylodes macrocephala, etc. are beneficial to improving spleen and stomach functions, promoting metabolism in the body, and further regulating blood sugar. By combining anti-inflammatory and antioxidant ingredients (such as quercetin, ferulic acid, tripterygium wilfordii polyglycosides, etc.), it can not only effectively lower blood sugar, but also improve chronic complications caused by diabetes. The effective ingredients in these medicinal materials can more comprehensively exert the effect of treating diabetes through synergistic effects.

[0022] 2. The present invention uses supercritical fluid extraction (SFE) technology to extract effective ingredients such as bitter melon, ferulic acid and chlorophyll, which can improve the extraction efficiency and maintain the stability and biological activity of the active ingredients. Compared with traditional decoction methods, technologies such as ultrasonic assisted extraction or hydrothermal extraction can more efficiently extract the effective ingredients in medicinal materials, reduce the dissolution of harmful substances, and improve the safety and efficacy of the preparation.

[0023] 3. The present invention adds probiotics and inulin to the formula, which helps to improve the intestinal microecology, regulate intestinal flora, promote drug absorption, and enhance the effect of treating diabetes. In addition, probiotics can further play an anti-diabetic role by regulating the immune system and reducing inflammatory responses. The addition of chlorophyll and quercetin also increases the antioxidant effect of the preparation to combat the oxidative stress damage common in diabetic patients. DETAILED DESCRIPTION

[0024] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0025] The invention provides a technical scheme: a pancreas-eliminating Chinese medicine preparation for treating diabetes, which comprises, by weight, 8-20 parts of bitter melon extract, 6-20 parts of atractylodes, 8-20 parts of white atractylodes, 10-25 parts of tuckahoe, 10-25 parts of radix ophiopogonis, 10-25 parts of stir-fried radish seeds, 8-20 parts of plantago seeds, 8-20 parts of capillaris, 7-22 parts of rhizoma anemarrhenae, 3-15 parts of scutellariae, 10-25 parts of polygonum cuspidatum, 8-25 parts of salvia miltiorrhiza, 6-22 parts of safflower, 3-10 parts of tripterygium wilfordii polyglycosides, 2-10 parts of quercetin, 2-8 parts of ferulic acid, 1-6 parts of chlorophyll, 0.5-5 parts of probiotics and 2-10 parts of inulin.

[0026] A method for preparing a traditional Chinese medicine preparation for treating diabetes mellitus according to any one of the above items comprises the following steps:

[0027] S1. Wash fresh and high-quality Atractylodes lancea, Atractylodes macrocephala, Poria cocos, Radix Glehniae, stir-fried Radish seeds, Plantago asiatica, Artemisia capillaris, Rhizoma Anemarrhenae, Radix Astragali, Polygonum cuspidatum, Salvia miltiorrhiza, Carthamus tinctorius, Tripterygium wilfordii glycosides, quercetin and ferulic acid, cut them into small pieces and grind them into powder, and extract bitter melon extract, ferulic acid and chlorophyll by supercritical fluid extraction;

[0028] S2. Lightly stir-fry the stir-fried radish seeds and Radix Glechomae chinensis, put Atractylodes lancea, Atractylodes macrocephala, Poria cocos, Radix Glechomae chinensis, stir-fried radish seeds, Plantago seeds, Artemisia capillaris, Rhizoma Anemarrhenae, Radix Astragali, Polygonum cuspidatum, Salvia miltiorrhizae, Carthamus tinctorius, Tripterygium wilfordii polyglycosides, quercetin and ferulic acid in a casserole according to the formula ratio, add an appropriate amount of water, the amount of water added is eight times the amount of the medicinal materials, first boil over high heat, then change to decocting for 45-70 minutes, and collect the extract in batches;

[0029] S3, adding bitter melon extract, ferulic acid and chlorophyll to the decoction, and heating and extracting the medicinal materials by ultrasonic-assisted extraction or hydrothermal extraction;

[0030] S4, filtering the decocted extract to remove impurities, concentrating the filtered extract, and further dehydrating the concentrate to form a concentrated Chinese medicine powder;

[0031] S5, the concentrated powder is put into capsules, each capsule can be adjusted as needed, the concentrated liquid is converted into granules by spray drying technology, and the concentrated liquid can also be further processed into oral liquid;

[0032] S6. After the Chinese medicine preparation is completed, it should be packaged appropriately. For granules and capsules, aluminum foil packaging should be used, and oral liquid should be stored in a cool and dry place.

[0033] Embodiment 1

[0034] A pancreatic-eliminating Chinese medicine preparation for treating diabetes comprises, by weight, 8 parts of bitter melon extract, 6 parts of atractylodes, 8 parts of white atractylodes, 10 parts of tuckahoe, 10 parts of euphorbia pulex, 10 parts of stir-fried radish seeds, 8 parts of plantain seeds, 8 parts of capillaris, 7 parts of anemarrhena, 3 parts of scutellaria baicalensis, 10 parts of polygonum cuspidatum, 8 parts of salvia miltiorrhiza, 6 parts of safflower, 3 parts of tripterygium wilfordii polyglycosides, 2 parts of quercetin, 2 parts of ferulic acid, 1-6 parts of chlorophyll, 0.5-5 parts of probiotics and 2-10 parts of inulin.

[0035] A method for preparing a traditional Chinese medicine preparation for treating diabetes mellitus according to any one of the above items comprises the following steps:

[0036] S1. Wash fresh and high-quality Atractylodes lancea, Atractylodes macrocephala, Poria cocos, Radix Glehniae, stir-fried Radish seeds, Plantago asiatica, Artemisia capillaris, Rhizoma Anemarrhenae, Radix Astragali, Polygonum cuspidatum, Salvia miltiorrhiza, Carthamus tinctorius, Tripterygium wilfordii glycosides, quercetin and ferulic acid, cut them into small pieces and grind them into powder, and extract bitter melon extract, ferulic acid and chlorophyll by supercritical fluid extraction;

[0037] S2. Lightly stir-fry the stir-fried radish seeds and Radix Glechomae chinensis, put Atractylodes lancea, Atractylodes macrocephala, Poria cocos, Radix Glechomae chinensis, stir-fried radish seeds, Plantago seeds, Artemisia capillaris, Rhizoma Anemarrhenae, Radix Astragali, Polygonum cuspidatum, Salvia miltiorrhizae, Carthamus tinctorius, Tripterygium wilfordii polyglycosides, quercetin and ferulic acid in a casserole according to the formula ratio, add an appropriate amount of water, the amount of water added is eight times the amount of the medicinal materials, first boil over high heat, then change to decocting for 45-70 minutes, and collect the extract in batches;

[0038] S3, adding bitter melon extract, ferulic acid and chlorophyll to the decoction, and heating and extracting the medicinal materials by ultrasonic-assisted extraction or hydrothermal extraction;

[0039] S4, filtering the decocted extract to remove impurities, concentrating the filtered extract, and further dehydrating the concentrate to form a concentrated Chinese medicine powder;

[0040] S5, the concentrated powder is put into capsules, each capsule can be adjusted as needed, the concentrated liquid is converted into granules by spray drying technology, and the concentrated liquid can also be further processed into oral liquid;

[0041] S6. After the Chinese medicine preparation is completed, it should be packaged appropriately. For granules and capsules, aluminum foil packaging should be used, and oral liquid should be stored in a cool and dry place.

[0042] Example 2

[0043] A pancreatic-eliminating Chinese medicinal preparation for treating diabetes comprises, by weight, 10 parts of bitter melon extract, 10 parts of atractylodes, 10 parts of white atractylodes, 15 parts of tuckahoe, 15 parts of radix phellodendri, 15 parts of stir-fried radish seeds, 10 parts of plantain seeds, 10 parts of capillaris, 10 parts of anemarrhena, 6 parts of radix scutellariae, 15 parts of polygonum cuspidatum, 15 parts of salvia miltiorrhiza, 12 parts of safflower, 6 parts of tripterygium wilfordii glycosides, 5 parts of quercetin, 4 parts of ferulic acid, 3 parts of chlorophyll, 2 parts of probiotics and 6 parts of inulin.

[0044] A method for preparing a traditional Chinese medicine preparation for treating diabetes mellitus according to any one of the above items comprises the following steps:

[0045] S1. Wash fresh and high-quality Atractylodes lancea, Atractylodes macrocephala, Poria cocos, Radix Glehniae, stir-fried Radish seeds, Plantago asiatica, Artemisia capillaris, Rhizoma Anemarrhenae, Radix Astragali, Polygonum cuspidatum, Salvia miltiorrhiza, Carthamus tinctorius, Tripterygium wilfordii glycosides, quercetin and ferulic acid, cut them into small pieces and grind them into powder, and extract bitter melon extract, ferulic acid and chlorophyll by supercritical fluid extraction;

[0046] S2. Lightly stir-fry the stir-fried radish seeds and Radix Glechomae chinensis, put Atractylodes lancea, Atractylodes macrocephala, Poria cocos, Radix Glechomae chinensis, stir-fried radish seeds, Plantago seeds, Artemisia capillaris, Rhizoma Anemarrhenae, Radix Astragali, Polygonum cuspidatum, Salvia miltiorrhizae, Carthamus tinctorius, Tripterygium wilfordii polyglycosides, quercetin and ferulic acid in a casserole according to the formula ratio, add an appropriate amount of water, the amount of water added is eight times the amount of the medicinal materials, first boil over high heat, then change to decocting for 45-70 minutes, and collect the extract in batches;

[0047] S3, adding bitter melon extract, ferulic acid and chlorophyll to the decoction, and heating and extracting the medicinal materials by ultrasonic-assisted extraction or hydrothermal extraction;

[0048] S4, filtering the decocted extract to remove impurities, concentrating the filtered extract, and further dehydrating the concentrate to form a concentrated Chinese medicine powder;

[0049] S5, the concentrated powder is put into capsules, each capsule can be adjusted as needed, the concentrated liquid is converted into granules by spray drying technology, and the concentrated liquid can also be further processed into oral liquid;

[0050] S6. After the Chinese medicine preparation is completed, it should be packaged appropriately. For granules and capsules, aluminum foil packaging is used, and oral liquid should be stored in a cool and dry place.

[0051] Example 3

[0052] A pancreatic-eliminating Chinese medicinal preparation for treating diabetes comprises, by weight, 20 parts of bitter melon extract, 20 parts of atractylodes, 20 parts of white atractylodes, 25 parts of tuckahoe, 25 parts of radix phellodendri, 25 parts of stir-fried radish seeds, 20 parts of plantain seeds, 20 parts of capillaris, 22 parts of rhizoma anemarrhenae, 15 parts of radix scutellariae, 25 parts of polygonum cuspidatum, 25 parts of salvia miltiorrhiza, 22 parts of safflower, 10 parts of tripterygium wilfordii glycosides, 10 parts of quercetin, 8 parts of ferulic acid, 6 parts of chlorophyll, 5 parts of probiotics and 10 parts of inulin.

[0053] A method for preparing a traditional Chinese medicine preparation for treating diabetes mellitus according to any one of the above items comprises the following steps:

[0054] S1. Cut fresh and high-quality Atractylodes lancea, Atractylodes macrocephala, Poria cocos, Euonymus alatus, stir-fried Raphanus sativus, Plantago asiatica, Artemisia capillaris, Anemarrhena asphodeloides, Rheum officinale, Polygonum cuspidatum, Salvia miltiorrhiza, Carthamus tinctorius, Tripterygium wilfordii glycosides, Quercetin, and Ferulic acid into small pieces after cleaning and grind them into powder. Extract bitter gourd extract, Ferulic acid, and Chlorophyll by supercritical fluid extraction;

[0055] S2. Stir-fry stir-fried Raphanus sativus and Euonymus alatus slightly. Place Atractylodes lancea, Atractylodes macrocephala, Poria cocos, Euonymus alatus, stir-fried Raphanus sativus, Plantago asiatica, Artemisia capillaris, Anemarrhena asphodeloides, Rheum officinale, Polygonum cuspidatum, Salvia miltiorrhiza, Carthamus tinctorius, Tripterygium wilfordii glycosides, Quercetin, and Ferulic acid in a casserole according to the formula ratio, add an appropriate amount of water, and the amount of water added is eight times the amount of the medicinal materials. First, bring to a boil over high heat, then change to low heat and simmer for 45 - 70 minutes. Collect the extract in portions;

[0056] S3. Add bitter gourd extract, Ferulic acid, and Chlorophyll to the decoction, and use ultrasonic-assisted extraction or hydrothermal extraction method to heat and extract the medicinal materials;

[0057] S4. Filter the extract after decoction to remove impurities, concentrate the filtered extract, and further dehydrate the concentrated solution to form a traditional Chinese medicine concentrated powder;

[0058] S5. Fill the concentrated powder into capsules, and each capsule can be adjusted as needed. Convert the concentrated solution into granules by spray drying technology, or further process the concentrated solution into oral liquid;

[0059] S6. After the traditional Chinese medicine preparation is completed, carry out appropriate packaging. For granules or capsules, use aluminum foil packaging, and the oral liquid should be stored in a cool and dry place.

[0060] Design an experiment:

[0061] 1. Experimental purpose: To evaluate the effects of the anti-pancreatic traditional Chinese medicine preparation for treating diabetes prepared by the present invention on the blood glucose level, pancreatic tissue morphology, and related biochemical indexes of diabetic rats.

[0062] 2. Experimental group setting:

[0063] Control group (Group A): Use existing diabetes treatment drugs on the market (such as metformin or insulin) as a control to observe their effects;

[0064] Experimental group: Low-dose group (Group B): Administer the anti-pancreatic traditional Chinese medicine preparation for treating diabetes prepared with the ingredients in Example 1; High-dose group (Group C): Administer the anti-pancreatic traditional Chinese medicine preparation for treating diabetes prepared with the ingredients in Example 3; Standard drug group (Group D): Administer the anti-pancreatic traditional Chinese medicine preparation for treating diabetes prepared with the ingredients in Example 2;

[0065] The experimental period is 8 weeks.

[0066] 3. Evaluation indicators: blood glucose levels (fasting blood glucose, postprandial blood glucose); pathological changes in pancreatic tissue (histological examination by HF staining); biochemical indicators (serum insulin, liver function, kidney function); weight changes. The experimental data are shown in Table 1:

[0067] Table 1 Index Data

[0068]

[0069] Summary of experimental results:

[0070] 1. Blood glucose levels: The experimental results showed that groups C and D exhibited significant decreases in fasting blood glucose and postprandial blood glucose. In particular, group C had blood glucose levels approaching the normal range; group B also had a certain degree of blood glucose reduction compared to group A, but the effect was relatively mild.

[0071] 2. Insulin levels: The serum insulin level in group C increased significantly, which may be related to the promotion of insulin secretion or improvement of insulin sensitivity by the traditional Chinese medicine preparation; there were no significant changes in the insulin levels in the control group (group A) and the low-dose group (group B), and the insulin level in the standard drug group (group D) also increased significantly.

[0072] 3. Liver and kidney functions: The liver and kidney function indicators in all experimental groups did not show significant abnormalities compared to the control group, indicating that the anti-pancreatic traditional Chinese medicine preparation for treating diabetes prepared in the present invention did not have obvious adverse effects on liver and kidney functions; the liver and kidney function indicators in the high-dose group (group C) and the standard drug group (group D) were close to the normal range and no obvious side effects occurred; the liver and kidney function indicators in the high-dose group (group C) and the standard drug group (group D) were close to the normal range and no obvious side effects occurred;

[0073] 4. Pathological changes in pancreatic tissue: Through histological examination, it was found that the pancreatic tissue in the control group (group A) had relatively severe pathological changes, mainly manifested as damage to pancreatic β cells and inflammatory reactions; the pathological changes in the pancreatic tissue in the high-dose group (group C) and the standard drug group (group D) were mild, indicating that the treatment had an obvious repair effect on the pancreas; the pancreatic tissue changes in the low-dose group (group B) were moderate, suggesting that the low-dose traditional Chinese medicine preparation had a certain protective effect, but the effect was not as significant as that of the high-dose group.

[0074] Experimental conclusion: The anti-pancreatic traditional Chinese medicine preparation prepared in Example 3 of the present invention has a significant hypoglycemic effect on diabetic rats at high doses, can improve islet function, reduce pancreatic damage, and does not have obvious adverse effects on liver and kidney functions; the effect of the anti-pancreatic traditional Chinese medicine preparation prepared in Example 1 at low doses is relatively mild, but still shows certain therapeutic potential; the anti-pancreatic traditional Chinese medicine preparation prepared in Example 2 is comparable to the traditional Chinese medicine group at standard doses, indicating that Example 3 in the present invention can be used as an adjuvant treatment method for diabetes.

[0075] In summary, the traditional Chinese medicine preparation for treating diabetes of the present invention has remarkable advantages such as multi-component synergy, modern extraction technology, high drug efficacy, and strong targeted curative effect. It can take into account the prevention and treatment of complications while treating diabetes, breaking through the limitations of traditional treatment methods. In addition, the preparation process of the present invention is efficient, the drug formula is reasonable, and multiple dosage forms are provided, which helps to improve the compliance of patients.

[0076] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine preparation for treating diabetes, characterized in that, By weight parts, it includes 8 - 20 parts of balsam pear extract, 6 - 20 parts of Atractylodes lancea, 8 - 20 parts of Atractylodes macrocephala, 10 - 25 parts of Poria cocos, 10 - 25 parts of Euonymus alatus, 10 - 25 parts of stir-fried Raphanus sativus, 8 - 20 parts of Plantago asiatica, 8 - 20 parts of Artemisia capillaris, 7 - 22 parts of Anemarrhena asphodeloides, 3 - 15 parts of Rheum officinale, 10 - 25 parts of Polygonum cuspidatum, 8 - 25 parts of Salvia miltiorrhiza, 6 - 22 parts of Carthamus tinctorius, 3 - 10 parts of tripterygium glycosides and 2 - 10 parts of quercetin.

2. The anti-pancreatic traditional Chinese medicine preparation for treating diabetes according to claim 1, characterized in that, It also includes 2 - 8 parts of ferulic acid and 1 - 6 parts of chlorophyll.

3. The anti-pancreatic traditional Chinese medicine preparation for treating diabetes according to claim 1, characterized in that, It also includes 0.5 - 5 parts of probiotics and 2 - 10 parts of inulin.

4. The anti-pancreatic traditional Chinese medicine preparation for treating diabetes according to claim 3, wherein, The balsam pear extract, ferulic acid and chlorophyll are prepared by cutting, drying, extracting, concentrating and drying the cleaned fresh balsam pear, ferulic acid and chlorophyll respectively.

5. The preparation method of a traditional Chinese medicine preparation for eliminating pancreas for treating diabetes according to any one of claims 1-4, characterized in that It includes the following steps: S1. Wash the fresh and high-quality Atractylodes lancea, Atractylodes macrocephala, Poria cocos, Euonymus alatus, stir-fried Raphanus sativus, Plantago asiatica, Artemisia capillaris, Anemarrhena asphodeloides, Rheum officinale, Polygonum cuspidatum, Salvia miltiorrhiza, Carthamus tinctorius, tripterygium glycosides, quercetin and ferulic acid, cut them into small pieces and grind them into powder, and extract the balsam pear extract, ferulic acid and chlorophyll by supercritical fluid extraction; S2. Slightly stir-fry the stir-fried Raphanus sativus and Euonymus alatus, place the Atractylodes lancea, Atractylodes macrocephala, Poria cocos, Euonymus alatus, stir-fried Raphanus sativus, Plantago asiatica, Artemisia capillaris, Anemarrhena asphodeloides, Rheum officinale, Polygonum cuspidatum, Salvia miltiorrhiza, Carthamus tinctorius, tripterygium glycosides, quercetin and ferulic acid in a casserole according to the formula ratio, add an appropriate amount of water, first bring to a boil over high heat, then change to low heat and decoct, and collect the extract in portions; S3. Add the balsam pear extract, ferulic acid and chlorophyll to the decoction, and use ultrasonic-assisted extraction or hydrothermal extraction method to heat and extract the medicinal materials; S4. Filter the decocted extract to remove impurities, concentrate the filtered extract, and further dehydrate the concentrated liquid to form a traditional Chinese medicine concentrated powder; S5. Fill the concentrated powder into capsules, and each capsule can be adjusted according to needs. Convert the concentrated liquid into granules by spray drying technology, or further process the concentrated liquid into oral liquid; S6. After the traditional Chinese medicine preparation is completed, carry out appropriate packaging. For granules or capsules, use aluminum foil packaging, and the oral liquid should be stored in a cool and dry place.

6. The preparation method of a traditional Chinese medicine preparation for treating diabetes according to claim 5, characterized in that, The amount of water added to the casserole in step S2 is eight times the amount of the medicinal materials.

7. The preparation method of a traditional Chinese medicine preparation for eliminating pancreas for treating diabetes according to claim 6, characterized in that, The low-heat decocting time of the medicinal materials in step S2 is 45 - 70 minutes.

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