Preparation and preparation method of tablet for treating rheumatoid arthritis

Abstract

The invention discloses a preparation method and a preparation method of a tablet for treating rheumatoid arthritis. The tablet is prepared from the following raw materials in parts by weight. The preparation method comprises the following steps: 1, preparing an additive, namely, gram of isobutylphenylpropionic acid, gram of diclofenac, gram of methotrexate, gram of leflunomide, gram of microcrystalline cellulose, gram of lactose, gram of croscarmellose sodium and gram of sodium carboxymethyl starch, and the additive is composed of a lubricant and an adhesive, and the preparation method comprises the following steps: 1, adjusting the formula; b) preparing raw materials; c) processing the raw materials; d) adding materials; step e) packaging treatment; step a) formula adjustment; the formula of the tablet is determined according to the magnitude of rheumatoid arthritis and application requirements. The aryl propionic acid belongs to an ibuprofen non-steroidal anti-inflammatory drug, and the synthesis of prostaglandin is reduced by inhibiting the activity of epoxidase, so that the inflammatory reaction and pain are relieved, the inflammation of rheumatoid arthritis is reduced, and the pain is reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of tablets for rheumatoid arthritis, and particularly to a preparation and preparation method of tablets for treating rheumatoid arthritis. Background Art

[0002] According to the patent disclosed on the Chinese Patent Network, the patent name is: A drug for treating rheumatic arthritis and rheumatoid arthritis and its preparation method, and the patent number is: CN102885961B. The present invention relates to a drug for treating rheumatic arthritis and rheumatoid arthritis and its preparation method. It is mainly prepared from drugs such as Polyrhachis vicina Roger, Zaocys dhumnades, Radix Aconiti Preparata, Radix Rehmanniae, Tripterygium hypoglaucum (Levl.) Hutch., Clematis chinensis Osbeck, Cynanchum paniculatum (Bunge) Kitagawa, Spatholobus suberectus Dunn, Epimedium brevicornu Maxim., Anemarrhena asphodeloides Bunge, Cornu Cervi Pantotrichum, Scorpio, Scolopendra, Pheretima, Panax notoginseng, Astragalus membranaceus (Fisch.) Bunge, Chaenomeles sinensis (Thouin) Koehne, Taxillus chinensis (DC.) Danser, Eucommia ulmoides Oliv., Achyranthes bidentata Blume, Ligusticum chuanxiong, etc. The present invention is used for the treatment of rheumatoid arthritis and rheumatic arthritis with finger morning stiffness, muscle and joint pain, flexion and extension disorders, muscle wasting, and joint stiffness and deformity, and has the effects of tonifying the kidney and strengthening bones, promoting blood circulation and dispelling wind, and dispelling cold and dampness, with definite curative effects and no toxic and side effects.

[0003] However, the preparation of the above-mentioned rheumatoid arthritis drug is cumbersome, and the drug cannot play its role according to the severity of rheumatoid arthritis during use, reducing the use effect of the tablets. Summary of the Invention

[0004] To solve the problems raised in the above background art, the purpose of the present invention is to provide a preparation and preparation method of tablets for treating rheumatoid arthritis, which has the advantage of convenient preparation and solves the problem that the drug cannot play its role according to the severity of rheumatoid arthritis.

[0005] To achieve the above purpose, the present invention provides the following technical solution: A preparation and preparation method of tablets for treating rheumatoid arthritis, the tablets are composed of the following raw materials in parts by weight; ibuprofen grams, diclofenac grams, methotrexate grams, leflunomide grams, microcrystalline cellulose grams, lactose grams, croscarmellose sodium grams, sodium carboxymethyl starch grams.

[0006] Preferably, the additive consists of a lubricant and a binder.

[0007] Preferably, it includes step a) formula adjustment; step b) raw material preparation: step c) raw material processing; step d) material addition; step e) packaging treatment;

[0008] Step a) formula adjustment; Determine the formula of the tablets according to the severity of rheumatoid arthritis and application requirements;

[0009] Step b) Prepare raw materials; Prepare the required raw materials. Ibuprofen, chemically known as isobutylphenylpropionic acid, is a white crystalline powder with a slightly specific odor. In tablet preparation, the common dosage is 0.1 to 0.3 grams per tablet. It has good antipyretic, analgesic, and anti-inflammatory effects and is significantly effective in relieving joint pain and swelling in patients with rheumatoid arthritis.

[0010] Diclofenac is a phenylacetic acid non-steroidal anti-inflammatory drug, and its mechanism of action is also to inhibit COX activity, with relatively strong anti-inflammatory and analgesic effects. The dosage of diclofenac in tablets is generally 25 to 75 grams per tablet. Compared with ibuprofen, it may be more effective in reducing inflammation and pain in rheumatoid arthritis.

[0011] Methotrexate is a folic acid antagonist that mainly inhibits dihydrofolate reductase, interferes with cell DNA synthesis, cell division, and proliferation, and has a strong inhibitory effect on proliferating immune cells such as lymphocytes, thereby controlling the progression of rheumatoid arthritis.

[0012] Leflunomide is an isoxazole immunomodulator, and its main mechanism of action is to inhibit the de novo synthesis pathway of pyrimidine, making activated lymphocytes in a resting state, thereby reducing autoimmune reactions.

[0013] Microcrystalline cellulose is a crystalline cellulose with a relatively small degree of polymerization prepared by partial hydrolysis of cellulose, and it has good compressibility, fluidity, and adsorbability.

[0014] Lactose is a disaccharide with good solubility and sweetness, and as a filler in tablets, it can improve the taste and compressibility of drugs.

[0015] Croscarmellose sodium is a cross-linked cellulose carboxymethyl ether sodium salt with strong water absorption and swelling properties. After the tablet comes into contact with water, it can quickly absorb water and cause the tablet to disintegrate, promoting the dissolution of the drug.

[0016] Sodium carboxymethyl starch is a starch carboxymethylation derivative that will quickly swell when exposed to water, and its volume can increase by hundreds of times, thereby causing the tablet to disintegrate.

[0017] Step c) Process raw materials; For ibuprofen raw materials, use a crusher for crushing, and the crushed material is screened through a sieve. Generally, it is required that the drug raw material passes through an 80 - 100 mesh sieve.

[0018] Three-dimensional motion mixer; Put the crushed and sieved ibuprofen raw materials, methotrexate, leflunomide, etc. together with fillers such as microcrystalline cellulose, lactose, and disintegrants such as croscarmellose sodium and sodium carboxymethyl starch into a three-dimensional motion mixer. The mixing time of the three-dimensional motion mixer is generally 15 to 30 minutes, and the rotation speed is appropriately adjusted according to the type and capacity of the mixer.

[0019] Fluidized bed granulator; When granulating, the wet granulation method is adopted. The mixed materials are mixed with an appropriate amount of binder such as an aqueous solution of polyvinylpyrrolidone, and the concentration of the binder is generally 5% to 10% to form granules.

[0020] Tablet press; The materials after mixing and granulating are put into the tablet press for tableting. The pressure of the tablet press needs to be adjusted according to the properties of the drug and excipients. Generally, the pressure is between 5 and 10 kN.

[0021] Coating pan; Adopting the film coating technology, using coating materials such as hydroxypropyl methylcellulose, the tablets are coated in the coating pan to complete the packaging.

[0022] Step d) Adding materials; The lubricant refers to magnesium stearate, which is a fine white powder that is light and sand-free, with a faint special odor. It mainly plays a lubricating role in the tablet preparation process, reducing the friction between particles and between particles and the punch and die ring of the tablet press, and preventing the occurrence of sticking to the punch.

[0023] The binder refers to polyvinylpyrrolidone, which is a synthetic water-soluble polymer compound. In tablet preparation, when the compressibility of the drug powder is poor, it can be used as a binder.

[0024] Step e) Packaging treatment; Coating pan; Adopting the film coating technology, using coating materials such as hydroxypropyl methylcellulose, the tablets are coated in the coating pan to complete the packaging.

[0025] Preferably, as the present invention, ibuprofen belongs to arylpropionic acid non-steroidal anti-inflammatory drugs, which reduce prostaglandin synthesis by inhibiting the activity of cyclooxygenase, thereby reducing inflammatory reactions and pain.

[0026] Preferably, as the present invention, methotrexate is an orange-yellow crystalline powder, and the common dosage in tablets is 7.5 to 20 mg per gram per week. It is one of the basic drugs for the treatment of rheumatoid arthritis.

[0027] Preferably, as the present invention, leflunomide has a dosage of generally 10 to 20 mg per gram per day in tablets, and is usually a white film-coated tablet. Its metabolite in the body has a long half-life and can continuously play an anti-rheumatic effect.

[0028] Preferably, as the present invention, the dosage of lactose in tablets varies according to the formula, generally accounting for 10% to 30% of the total tablet weight. For example, the dosage per tablet may be between 30 and 80 mg.

[0029] Preferably in the present invention, the amount of sodium carboxymethylcellulose cross-linked is generally 2% to 10% of the total weight of the tablet, such as 5 to 20 mg per tablet. In the tablets for treating rheumatoid arthritis, it can ensure the rapid disintegration of the drug in the gastrointestinal tract and enable the drug to take effect in a timely manner.

[0030] Preferably in the present invention, the amount of sodium carboxymethyl starch usually accounts for 2% to 8% of the total weight of the tablet, generally about 3 to 5 mg per tablet. It is also a highly efficient disintegrant and is applicable to tablets of poorly soluble drugs.

[0031] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0032] In the present invention, through arylpropionic acid, which belongs to ibuprofen non-steroidal anti-inflammatory drugs, by inhibiting the activity of cyclooxygenase and reducing the synthesis of prostaglandins, the inflammatory reaction and pain are reduced, thereby reducing the inflammation and pain of rheumatoid arthritis. Specific embodiments

[0033] Next, in combination with the embodiments of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0034] The present invention provides a preparation and preparation method of a tablet for treating rheumatoid arthritis. The tablet is composed of the following raw materials in parts by weight: ibuprofen 0.1 - 0.3 g, diclofenac 25 - 75 g, methotrexate 7.5 - 20 g, leflunomide 10 - 20 g, microcrystalline cellulose 50 - 100 g, lactose 30 - 80 g, sodium carboxymethylcellulose cross-linked 5 - 20 g, sodium carboxymethyl starch 3 - 15 g.

[0035] The present invention is further arranged such that the additive consists of a lubricant and a binder.

[0036] The present invention is further arranged to include step a) formula adjustment; step b) raw material preparation; step c) raw material processing; step d) material addition; step e) packaging treatment;

[0037] Step a) Formula adjustment: Determine the formula of the tablet according to the severity of rheumatoid arthritis and application requirements;

[0038] Step b) Prepare raw materials; Prepare the required raw materials. Ibuprofen, chemically known as isobutylphenylpropionic acid, is a white crystalline powder with a slightly specific odor. In tablet preparation, the common dosage is 0.1 to 0.3 grams per tablet. It has good antipyretic, analgesic and anti-inflammatory effects, and is significantly effective in relieving joint pain and swelling in patients with rheumatoid arthritis;

[0039] Diclofenac is a phenylacetic acid non-steroidal anti-inflammatory drug, and its mechanism of action is also to inhibit COX activity, with strong anti-inflammatory and analgesic effects. The dosage of diclofenac in tablets is generally 25 to 75 grams per tablet. Compared with ibuprofen, it may be more effective in reducing inflammation and pain in rheumatoid arthritis;

[0040] Methotrexate is a folic acid antagonist, which mainly inhibits dihydrofolate reductase, interferes with cell DNA synthesis, cell division and proliferation, and has a strong inhibitory effect on proliferating immune cells such as lymphocytes, thus controlling the progression of rheumatoid arthritis;

[0041] Leflunomide is an isoxazole immunomodulator, and its main mechanism of action is to inhibit the de novo synthesis pathway of pyrimidine, making activated lymphocytes in a resting state, thereby reducing autoimmune reactions;

[0042] Microcrystalline cellulose is a crystalline cellulose with a small degree of polymerization prepared by partial hydrolysis of cellulose, and has good compressibility, fluidity and adsorption;

[0043] Lactose is a disaccharide with good solubility and sweetness, and can improve the taste and compressibility of drugs as a filler in tablets;

[0044] Croscarmellose sodium is a cross-linked cellulose carboxymethyl ether sodium salt, which has strong water absorption and swelling properties. After the tablet contacts water, it can quickly absorb water to disintegrate the tablet and promote the dissolution of the drug;

[0045] Sodium carboxymethyl starch is a starch carboxymethylation derivative, which will quickly swell when encountering water, and the volume can increase hundreds of times, thus disintegrating the tablet;

[0046] Step c) Process raw materials; For ibuprofen raw material medicine, use a pulverizer to pulverize it, and the pulverized material is screened through a sieve. Generally, it is required that the drug raw material passes through an 80- to 100-mesh sieve;

[0047] Three-dimensional motion mixer; Put the pulverized and sieved ibuprofen raw material medicine, methotrexate, leflunomide, etc. and fillers such as microcrystalline cellulose, lactose, disintegrants such as croscarmellose sodium, sodium carboxymethyl starch into a three-dimensional motion mixer. The mixing time of the three-dimensional motion mixer is generally 15 to 30 minutes, and the rotation speed is appropriately adjusted according to the type and capacity of the mixer;

[0048] Fluidized bed granulator; When granulating, the wet granulation method is adopted. The mixed materials are mixed with an appropriate amount of binder, such as an aqueous solution of polyvinylpyrrolidone. The concentration of the binder is generally 5% to 10% to form granules.

[0049] Tablet press; The materials after mixing and granulating are put into the tablet press for tableting. The pressure of the tablet press needs to be adjusted according to the properties of the drug and excipients. Generally, the pressure is between 5 and 10 kN.

[0050] Coating pan; Adopting the film coating technology, using coating materials such as hydroxypropyl methylcellulose, the tablets are coated in the coating pan to complete the packaging.

[0051] Step d) Adding materials; The lubricant refers to magnesium stearate, which is a fine white powder that is light and sand-free, with a faint special odor. It mainly plays a lubricating role in the tablet preparation process, reducing the friction between particles and between particles and the punch and die of the tablet press, and preventing the occurrence of sticking to the punch.

[0052] The binder refers to polyvinylpyrrolidone, which is a synthetic water-soluble polymer compound. In tablet preparation, when the compressibility of the drug powder is poor, it can be used as a binder.

[0053] Step e) Packaging treatment; Coating pan; Adopting the film coating technology, using coating materials such as hydroxypropyl methylcellulose, the tablets are coated in the coating pan to complete the packaging.

[0054] The present invention is further provided that ibuprofen belongs to arylpropionic acid non-steroidal anti-inflammatory drugs. By inhibiting the activity of cyclooxygenase, it reduces the synthesis of prostaglandins, thereby reducing the inflammatory reaction and pain.

[0055] The present invention is further provided that methotrexate is an orange-yellow crystalline powder. The common dosage in tablets is 7.5 to 20 mg per gram per week, and it is one of the basic drugs for the treatment of rheumatoid arthritis.

[0056] The present invention is further provided that leflunomide has a dosage of generally 10 to 20 mg per gram per day in tablets, usually as white film-coated tablets. Its metabolite in the body has a long half-life and can continuously play an anti-rheumatic role.

[0057] The present invention is further provided that the dosage of lactose in tablets varies according to the formula, generally accounting for 10% to 30% of the total tablet weight. For example, the dosage per tablet may be between 30 and 80 mg.

[0058] The present invention is further configured such that the dosage of sodium carboxymethylcellulose cross-linked is generally 2% to 10% of the total weight of the tablets. For example, the dosage per tablet is between 5 and 20 mg. In the tablets for treating rheumatoid arthritis, it can ensure the rapid disintegration of the drug in the gastrointestinal tract, enabling the drug to exert its effect in a timely manner.

[0059] The present invention is further configured such that the dosage of sodium carboxymethyl starch usually accounts for 2% to 8% of the total weight of the tablets. Generally, the dosage per tablet is about 3 to 5 mg. It is also a highly efficient disintegrant and is suitable for tablets of poorly soluble drugs.

[0060] The working principle and usage process of the present invention: When in use, materials are first preselected. Ibuprofen, whose chemical name is isobutylphenylpropionic acid, is a white crystalline powder with a slightly specific odor. In tablet preparation, the common dosage is 0.1 to 0.3 g per tablet. It has good antipyretic, analgesic, and anti-inflammatory effects. For the raw material of isobutylphenylpropionic acid, a pulverizer is used for pulverization. The pulverized material is screened through a sieve. Generally, it is required that the drug raw material passes through an 80- to 100-mesh sieve. The pulverized and sieved raw material of isobutylphenylpropionic acid, methotrexate, leflunomide, etc., and fillers such as microcrystalline cellulose, lactose, and disintegrants such as sodium carboxymethylcellulose cross-linked and sodium carboxymethyl starch are put into a three-dimensional motion mixer. When granulating, the wet granulation method is adopted. The mixed material is mixed with an appropriate amount of binder such as an aqueous solution of polyvinylpyrrolidone. The concentration of the binder is generally 5% to 10% to form granules. The material after mixing and granulating is put into a tableting machine for tableting. The pressure of the tableting machine needs to be adjusted according to the properties of the drug and excipients. Generally, the pressure is between 5 and 10 kN. Finally, the film coating technology is adopted, and coating materials such as hydroxypropyl methylcellulose are used to coat the tablets in a coating pan to complete the packaging.

[0061] In summary: The preparation method of the tablets for treating rheumatoid arthritis, through the combined use of isobutylphenylpropionic acid grams, diclofenac grams, methotrexate grams, leflunomide grams, microcrystalline cellulose grams, lactose grams, sodium carboxymethylcellulose cross-linked grams, and sodium carboxymethyl starch grams, solves the problem that the medicament cannot exert its effect according to the severity of rheumatoid arthritis during use.

[0062] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "comprising", "including" or any other variation thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements but also includes other elements not expressly listed, or further includes elements inherent to such process, method, article or device.

[0063] Although embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A tablet for treating rheumatoid arthritis, characterized in that; The tablet is composed of the following raw materials in parts by weight: ibuprofen 0.1 - 0.3 g, diclofenac 25 - 75 g, methotrexate 7.5 - 20 g, leflunomide 10 - 20 g, microcrystalline cellulose 50 - 100 g, lactose 30 - 80 g, croscarmellose sodium 5 - 20 g, sodium carboxymethyl starch 3 - 15 g.

2. The tablet for treating rheumatoid arthritis according to claim 1, wherein: The additive consists of a lubricant and a binder.

3. The preparation method of a tablet for treating rheumatoid arthritis according to any one of claims 1-2, characterized in that: It includes step a) formulation adjustment; step b) raw material preparation; step c) raw material processing; step d) material addition; step e) packaging treatment. Step a) formulation adjustment; Determine the formulation of the tablet according to the severity of rheumatoid arthritis and application requirements. Step b) raw material preparation; Prepare the required raw materials. The chemical name of ibuprofen is ibuprofen, which is a white crystalline powder with a slightly specific odor. In tablet preparation, the common dosage is 0.1 to 0.3 grams per tablet. It has good antipyretic, analgesic and anti-inflammatory effects, and is obvious in relieving joint pain and swelling of rheumatoid arthritis patients. Diclofenac is a phenylacetic acid non-steroidal anti-inflammatory drug, and its mechanism of action is also to inhibit COX activity, with strong anti-inflammatory and analgesic effects. The dosage of diclofenac in tablets is generally 25 to 75 grams per tablet. Compared with ibuprofen, it may be more effective in reducing inflammation and pain of rheumatoid arthritis. Methotrexate is a folic acid antagonist, which mainly inhibits dihydrofolate reductase, interferes with cell DNA synthesis, cell division and proliferation, and has a strong inhibitory effect on proliferating immune cells such as lymphocytes, thereby controlling the progression of rheumatoid arthritis. Leflunomide is an isoxazole immunomodulator, and its main mechanism of action is to inhibit the de novo synthesis pathway of pyrimidine, so that activated lymphocytes are in a resting state, thereby reducing autoimmune reactions. Microcrystalline cellulose is a crystalline cellulose with a relatively small degree of polymerization prepared by partial hydrolysis of cellulose, and has good compressibility, fluidity and adsorption. Lactose is a disaccharide with good solubility and sweetness, and can improve the taste and compressibility of drugs as a filler in tablets. Croscarmellose sodium is a cross-linked cellulose carboxymethyl ether sodium salt, which has strong water absorption and swelling properties. After the tablet contacts water, it can quickly absorb water and cause the tablet to disintegrate, promoting the dissolution of the drug. Sodium carboxymethyl starch is a starch carboxymethylation derivative, which will quickly expand when encountering water, and the volume can increase hundreds of times, thereby causing the tablet to disintegrate. Step c) raw material processing. For ibuprofen raw material medicine, use a pulverizer to pulverize it, and the pulverized material is screened through a sieve. Generally, it is required that the drug raw material passes through an 80 - 100 mesh sieve. Three-dimensional motion mixer; Put the pulverized and sieved ibuprofen raw material medicine, methotrexate, leflunomide, etc. and fillers such as microcrystalline cellulose, lactose, disintegrants such as croscarmellose sodium, sodium carboxymethyl starch into the three-dimensional motion mixer. The mixing time of the three-dimensional motion mixer is generally 15 - 30 minutes, and the rotation speed is appropriately adjusted according to the type and capacity of the mixer. Fluidized bed granulator; When granulating, the wet granulation method is adopted. The mixed materials are mixed with an appropriate amount of binder, such as an aqueous solution of polyvinylpyrrolidone. The concentration of the binder is generally 5% to 10% to form granules. Tablet press; The materials after mixing and granulating are put into the tablet press for tableting. The pressure of the tablet press needs to be adjusted according to the properties of the drug and excipients. Generally, the pressure is between 5 and 10 kN. Coating pan; The film coating technology is adopted, and coating materials such as hydroxypropyl methylcellulose are used to coat the tablets in the coating pan to complete the packaging. Step d) Adding materials The lubricant refers to magnesium stearate, which is a fine white powder that is light and sand-free, with a weak special odor. It mainly plays a lubricating role in the tablet preparation process, reducing the friction between particles and between particles and the punch and die of the tablet press, and preventing the occurrence of sticking to the punch. The binder refers to polyvinylpyrrolidone, which is a synthetic water-soluble polymer compound. In tablet preparation, when the compressibility of the drug powder is poor, it can be used as a binder. Step e) Packaging treatment; Coating pan; The film coating technology is adopted, and coating materials such as hydroxypropyl methylcellulose are used to coat the tablets in the coating pan to complete the packaging.

4. The preparation method of a tablet for treating rheumatoid arthritis according to claim 3, characterized in that: The ibuprofen belongs to arylpropionic acid non-steroidal anti-inflammatory drugs. By inhibiting the activity of cyclooxygenase, it reduces the synthesis of prostaglandins, thereby reducing the inflammatory response and pain.

5. The preparation method of a tablet for treating rheumatoid arthritis according to claim 3, characterized in that: The methotrexate is an orange-yellow crystalline powder. The common dosage in tablets is 7.5 to 20 per gram per week. It is one of the basic drugs for the treatment of rheumatoid arthritis.

6. The preparation method of a tablet for treating rheumatoid arthritis according to claim 3, characterized in that: The leflunomide has a dosage of generally 10 to 20 per gram per day in tablets and is usually a white film-coated tablet. Its metabolite in the body has a long half-life and can continuously play an anti-rheumatic role.

7. The preparation method of a tablet for treating rheumatoid arthritis according to claim 3, characterized in that: The dosage of the lactose in tablets varies according to the formula, generally accounting for 10% to 30% of the total tablet weight. For example, the dosage per tablet may be between 30 and 80 per gram.

8. The preparation method of a tablet for treating rheumatoid arthritis according to claim 3, characterized in that: The croscarmellose sodium has a dosage of generally 2% to 10% of the total tablet weight. For example, the dosage per tablet is between 5 and 20 per gram. In the tablets for the treatment of rheumatoid arthritis, it can ensure the rapid disintegration of the drug in the gastrointestinal tract and enable the drug to play a role in a timely manner.

9. The preparation method of a tablet for treating rheumatoid arthritis according to claim 3, characterized in that: The sodium carboxymethyl starch usually accounts for 2% to 8% of the total tablet weight. Generally, the dosage per tablet is about 3 to 5 per gram. It is also a highly efficient disintegrant and is suitable for tablets of poorly soluble drugs.