Composition capable of supplementing fundus nerve nutrition and having anti-fatigue and anti-oxidation functions

Abstract

The invention relates to the technical field of medicines, in particular to a composition with anti-fatigue and anti-oxidation functions for supplementing fundus nerve nutrition. The health-care food is prepared from the following components in parts by weight: 8 to 10 parts of semen cassiae, 6 to 8 parts of fructus lycii, 6 to 8 parts of herba dendrobii, 6 to 8 parts of flos chrysanthemi, 4 to 6 parts of longan, 2 to 3 parts of spirulina platensis, 2 to 3 parts of semen ginkgo, 0.1 to 0.3 part of vitamin A, 0.2 to 0.4 part of vitamin B, 0.2 to 0.5 part of vitamin C, 0.2 to 0.5 part of vitamin E, 0.2 to 0.5 part of zinc, 0.1 to 0.3 part of copper, 0.3 to 0.6 part of nicotinic acid, 0.5 to 1.5 parts of lutein ester, 0.1 to 0.5 part of zeaxanthin, 0.6 to 0.9 part of astaxanthin and 0.3 to 0.5 part of blueberry anthocyanin. The feed additive is prepared from the following components in parts by weight: 0.4-0.6 part of euphausia superba, 0.5-0.7 part of DHA algal oil, 0.1-0.3 part of glutathione and 0.2-0.4 part of The composition can quickly supplement nutrition to the fundus nerves, has anti-fatigue and anti-oxidation functions on the fundus nerves, and solves the problem of eyestrain.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly to a composition with the functions of supplementing the nutrition of the optic fundus nerves and having anti-fatigue and antioxidant effects. Background Art

[0002] With the development of society, various intelligent devices (such as mobile phones, tablets, computers, etc.) have become essential equipment for people's life and work. People use the above-mentioned intelligent devices for a long time, resulting in excessive eye use.

[0003] Eye fatigue is mainly caused by the reduction of the blinking frequency of the eyes when people concentrate on watching TV, computer or mobile phone screens, etc., resulting in a corresponding reduction in tear secretion. At the same time, the flickering screen strongly stimulates the eyes. It is usually caused by long-term eye use, environmental factors or potential health problems. The reasons are generally described as follows: (1) Excessive eye use: Staring at the screen (computer, mobile phone, etc.), reading, driving, etc. for a long time, resulting in a reduction in the blinking frequency and continuous tension of the eye muscles. (2) Environmental factors: Dry air, strong light, glare, dim light or low humidity in the air-conditioned room. (3) Vision problems: Uncorrected myopia, hyperopia, astigmatism or presbyopia. (4) Other health problems: Dry eye, conjunctivitis, glaucoma or systemic diseases, such as diabetes, hyperthyroidism, etc.

[0004] Therefore, the traditional solution is to relieve eye fatigue by improving the eye regulation function with drugs. For example, Diclofenac Sodium and Digitoxin Eye Drops act on the ciliary muscle to improve the eye regulation function by enhancing the function of the ciliary muscle and increasing the blood flow of the ciliary muscle. Another example is the use of some eye drops such as Zhenzhu Mingmu Ye, Naphazoline Hydrochloride, Taurine, etc., which have a certain effect on relieving eye fatigue. However, long-term use is likely to cause drug dependence, and the curative effect will also decline after long-term use. Another example is some physical therapies such as fogging method, distance vision method and eye exercises, etc. The main purpose of non-drug treatment is to improve the blood circulation around the eyes and play an auxiliary role in the treatment of visual fatigue. The company adopts a different solution from the above, using the method of supplementing the nutrition of the optic fundus nerves to improve its anti-fatigue and antioxidant functions, so as to protect the eyes, reduce fatigue and be beneficial to the eyes without affecting the necessary use of the above-mentioned electronic intelligent devices in life and work. Summary of the Invention

[0005] The purpose of the present invention is to provide a composition with the functions of supplementing the nutrition of the optic fundus nerves and having anti-fatigue and antioxidant effects in view of the defects and deficiencies of the prior art.

[0006] The composition with the functions of supplementing the nutrition of the optic fundus nerves and having anti-fatigue and antioxidant effects described in the present invention has the following components by weight ratio:

[0007] Cassia Seed 8 - 10 parts, Chinese Wolfberry 6 - 8 parts, Dendrobium 6 - 8 parts, Chrysanthemum 6 - 8 parts, Longan 4 - 6 parts, Spirulina 2 - 3 parts, Ginkgo Seed 2 - 3 parts,

[0008] 0.1 - 0.3 parts of vitamin A, 0.2 - 0.4 parts of vitamin B, 0.2 - 0.5 parts of vitamin C, 0.2 - 0.5 parts of vitamin E, 0.2 - 0.5 parts of zinc, 0.1 - 0.3 parts of copper, 0.3 - 0.6 parts of niacin,

[0009] 0.5 - 1.5 parts of lutein ester, 0.1 - 0.5 parts of zeaxanthin, 0.6 - 0.9 parts of astaxanthin, 0.3 - 0.5 parts of blueberry anthocyanins, 0.4 - 0.6 parts of Antarctic krill, 0.5 - 0.7 parts of DHA algal oil,

[0010] 0.1 - 0.3 parts of glutathione, 0.2 - 0.4 parts of bilberry extract.

[0011] Furthermore, a composition for supplementing fundus nerve nutrition and having anti - fatigue and antioxidant functions has the following components by weight ratio:

[0012] 8 parts of cassia seed, 6 parts of wolfberry, 6 parts of dendrobium, 7 parts of chrysanthemum, 5 parts of longan, 0.1 part of vitamin A, 0.2 part of vitamin B, 0.2 part of vitamin C, 0.2 part of vitamin E, 0.2 part of zinc, 0.1 part of copper, 0.3 part of niacin,

[0013] 0.5 part of lutein ester, 0.1 part of zeaxanthin, 0.6 part of astaxanthin, 0.3 part of blueberry anthocyanins, 0.4 part of Antarctic krill, 0.5 part of DHA algal oil, 0.1 part of glutathione, 0.2 part of bilberry extract.

[0014] Furthermore, a composition for supplementing fundus nerve nutrition and having anti - fatigue and antioxidant functions has the following components by weight ratio:

[0015] 10 parts of cassia seed, 7 parts of wolfberry, 6 parts of dendrobium, 6 parts of chrysanthemum, 4 parts of longan, 0.2 part of vitamin A, 0.3 part of vitamin B, 0.3 part of vitamin C, 0.3 part of vitamin E, 0.4 part of zinc, 0.3 part of copper, 0.5 part of niacin,

[0016] 1.5 parts of lutein ester, 0.3 part of zeaxanthin, 0.7 part of astaxanthin, 0.4 part of blueberry anthocyanins, 0.5 part of Antarctic krill, 0.6 part of DHA algal oil, 0.2 part of glutathione, 0.3 part of bilberry extract.

[0017] The preparation process of the composition for supplementing fundus nerve nutrition and having anti - fatigue and antioxidant functions adopts the following steps:

[0018] S10: Take 8 - 10 parts of cassia seed, 6 - 8 parts of wolfberry, 6 - 8 parts of dendrobium, 6 - 8 parts of chrysanthemum, 4 - 6 parts of longan, add them to a stirring tank, grind them, and add an appropriate amount of distilled water, stir evenly to form an initial liquid;

[0019] S20: In the initial liquid in step S10, add 0.1 - 0.3 parts of vitamin A, 0.2 - 0.4 parts of vitamin B, 0.2 - 0.5 parts of vitamin C, 0.2 - 0.5 parts of vitamin E, 0.2 - 0.5 parts of zinc, 0.1 - 0.3 parts of copper, 0.3 - 0.6 parts of niacin, 0.1 - 0.3 parts of glutathione, and 0.2 - 0.4 parts of bilberry extract respectively, and then evenly stir with a blender to form a mixed liquid;

[0020] S30: Add 0.5 parts of lutein ester, 0.1 part of zeaxanthin, 0.6 parts of astaxanthin, 0.3 parts of blueberry anthocyanins, 0.4 parts of Antarctic krill, and 0.5 parts of DHA algal oil to the mixed liquid in step S20, heat and decoct 3 - 5 times, 20 - 30 minutes each time, to form a concentrated liquid; then adjust the pH value of the concentrated liquid with borate buffer, and the pH value is between 6.5 and 7.

[0021] The beneficial effects of the present invention are as follows: The composition for supplementing fundus nerve nutrition with anti - fatigue and antioxidant functions described in the present invention uses cassia seed, wolfberry, dendrobium, chrysanthemum, and longan which are both medicine and food, and lutein ester, zeaxanthin, astaxanthin, blueberry anthocyanins, Antarctic krill, and DHA algal oil which are new resource foods as antioxidants, and is supplemented with trace elements to form the eye drops of the present invention, which can quickly supplement fundus nerve nutrition, has anti - fatigue and antioxidant functions for fundus nerves, and solves the problem of eye fatigue. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The drawings described herein are used to provide a further understanding of the present invention, form a part of this application, but do not constitute an improper limitation to the present invention. In the drawings:

[0023] Figure 1 is a topological schematic diagram of the preparation process of the present invention; DETAILED DESCRIPTION OF THE EMBODIMENTS

[0024] The following will detail the present invention in conjunction with the drawings and specific embodiments, where the illustrative embodiments and descriptions are only used to explain the present invention, but do not limit the present invention.

[0025] The composition for supplementing fundus nerve nutrition with anti - fatigue and antioxidant functions described in this specific embodiment has the following components by weight ratio:

[0026] Cassia seed 8 - 10 parts, wolfberry 6 - 8 parts, dendrobium 6 - 8 parts, chrysanthemum 6 - 8 parts, longan 4 - 6 parts, spirulina 2 - 3 parts, ginkgo seed 2 - 3 parts,

[0027] 0.1 - 0.3 parts of vitamin A, 0.2 - 0.4 parts of vitamin B, 0.2 - 0.5 parts of vitamin C, 0.2 - 0.5 parts of vitamin E, 0.2 - 0.5 parts of zinc, 0.1 - 0.3 parts of copper, 0.3 - 0.6 parts of niacin,

[0028] 0.5 - 1.5 parts of lutein ester, 0.1 - 0.5 parts of zeaxanthin, 0.6 - 0.9 parts of astaxanthin, 0.3 - 0.5 parts of blueberry anthocyanins, 0.4 - 0.6 parts of Antarctic krill, 0.5 - 0.7 parts of DHA algal oil,

[0029] 0.1 - 0.3 parts of glutathione, 0.2 - 0.4 parts of bilberry extract.

[0030] Furthermore, a composition for supplementing fundus nerve nutrition and having anti - fatigue and antioxidant functions has the following components by weight ratio:

[0031] 8 parts of cassia seed, 6 parts of Chinese wolfberry, 6 parts of dendrobium, 7 parts of chrysanthemum, 5 parts of longan, 2 parts of spirulina, 2 parts of ginkgo seeds,

[0032] 0.1 part of vitamin A, 0.2 part of vitamin B, 0.2 part of vitamin C, 0.2 part of vitamin E, 0.2 part of zinc, 0.1 part of copper, 0.3 part of niacin,

[0033] 0.5 part of lutein ester, 0.1 part of zeaxanthin, 0.6 part of astaxanthin, 0.3 part of blueberry anthocyanins, 0.4 part of Antarctic krill, 0.5 part of DHA algal oil, 0.1 part of glutathione, 0.2 part of bilberry extract.

[0034] Furthermore, a composition for supplementing fundus nerve nutrition and having anti - fatigue and antioxidant functions has the following components by weight ratio:

[0035] 10 parts of cassia seed, 7 parts of Chinese wolfberry, 6 parts of dendrobium, 6 parts of chrysanthemum, 4 parts of longan, 3 parts of spirulina, 3 parts of ginkgo seeds,

[0036] 0.2 part of vitamin A, 0.3 part of vitamin B, 0.3 part of vitamin C, 0.3 part of vitamin E, 0.4 part of zinc, 0.3 part of copper, 0.5 part of niacin,

[0037] 1.5 parts of lutein ester, 0.3 part of zeaxanthin, 0.7 part of astaxanthin, 0.4 part of blueberry anthocyanins, 0.5 part of Antarctic krill, 0.6 part of DHA algal oil, 0.2 part of glutathione, 0.3 part of bilberry extract.

[0038] As Figure 1 shown, the preparation process of the composition for supplementing fundus nerve nutrition and having anti - fatigue and antioxidant functions adopts the following steps:

[0039] S10: Take 8 - 10 parts of cassia seed, 6 - 8 parts of wolfberry, 6 - 8 parts of dendrobium, 6 - 8 parts of chrysanthemum, and 4 - 6 parts of longan. Add them to a mixing tank, grind them, and add an appropriate amount of distilled water, then stir evenly to form an initial liquid.

[0040] S20: In the initial liquid from step S10, add 0.1 - 0.3 parts of vitamin A, 0.2 - 0.4 parts of vitamin B, 0.2 - 0.5 parts of vitamin C, 0.2 - 0.5 parts of vitamin E, 0.2 - 0.5 parts of zinc, 0.1 - 0.3 parts of copper, 0.3 - 0.6 parts of niacin, 0.1 - 0.3 parts of glutathione, and 0.2 - 0.4 parts of bilberry extract respectively. Then, use a blender to stir evenly to form a mixed liquid.

[0041] S30: Add 0.5 parts of lutein ester, 0.1 part of zeaxanthin, 0.6 parts of astaxanthin, 0.3 parts of blueberry anthocyanins, 0.4 parts of Antarctic krill, and 0.5 parts of DHA algal oil to the mixed liquid from step S20. Heat and decoct it 3 - 5 times, 20 - 30 minutes each time, to form a concentrated liquid. Then, adjust the pH value of the concentrated liquid with borate buffer solution, and the pH value is between 6.5 - 7.

[0042] In the present invention, lutein ester, zeaxanthin, astaxanthin, blueberry anthocyanins, Antarctic krill, and DHA algal oil are antioxidants and belong to new resource foods. Zeaxanthin and another carotenoid, "lutein ester", together constitute the pigment in the macular area of the human eye retina. By absorbing harmful blue light and reducing oxidative stress, it protects eyesight.

[0043] For the new resource foods in the present invention, the proportioning amounts are as follows: lutein ester and zeaxanthin are combined in a golden ratio of 5:1, with 10 mg of lutein ester and 2 mg of zeaxanthin; the extract of haematococcus pluvialis (astaxanthin) ≤ 0.8 g / day; blueberry anthocyanins ≤ 800 mg / day; Antarctic krill omega3 ≤ 3 g / day; DHA algal oil ≤ 300 mg / day (calculated as pure DHA), and (3R,3'S)-dihydroxy-β-carotene (zeaxanthin) ≤ 8 mg / day.

[0044] For the daily proportioning amounts of each trace element in this design, they are as follows: vitamin A, 120 - 375 μg / day; vitamin B12, 0.4 - 4 μg / day; vitamin C, 15 - 100 mg / day; vitamin E, 2.1 - 20 mg α-TE / day; zinc, 1.7 - 12 mg / day; copper, 0.3 - 1.5 mg / day; niacin (nicotinic acid), 2.1 - 20 mg / day.

[0045] In the present invention, Cassia seed, Chinese wolfberry, Dendrobium, Chrysanthemum and Longan are both medicinal and edible. They have protective and nourishing effects on the eyes, and the principle is mainly based on their active ingredients and the regulation of the functions of internal organs such as liver and kidney. Visual fatigue + Qi and blood deficiency: Physical treatment through Chinese wolfberry + Longan + Dendrobium (blood tonic + Yin nourishing). Dry eye syndrome is physical treatment through "Dendrobium + Chrysanthemum (promoting body fluid + clearing heat)".

[0046] For eye diseases, the Cassia seed in the present invention can clear liver fire. Traditional Chinese medicine believes that "the liver opens the eyes", and liver fire can easily lead to red, swollen, painful and dry eyes. Cassia seed is slightly cold in nature and can clear liver heat, relieve redness and fatigue of the eyes. It is rich in antioxidant ingredients: containing chrysophanol, rhamnolide, etc., which can reduce the damage of free radicals to the retina and improve intraocular pressure: modern research suggests that it may assist in regulating intraocular pressure (with certain potential benefits for glaucoma). Target population: red, swollen eyes, dryness, blurred vision (especially those with liver fire or long-term excessive use of eyes).

[0047] The effects of wolfberry: nourishes the liver and kidneys, improves sperm quality and improves eyesight. Applicable symptoms: decreased vision, dry eyes, senile dizziness, and eye fatigue after staying up late.

[0048] Dendrobium is suitable for the following symptoms: dry eyes, diabetic retinopathy (needs treatment), and senile blurred vision.

[0049] Chrysanthemum, dispels wind and heat, soothes the liver and improves eyesight, and is targeted at problems such as red and swollen eyes, itchy and painful eyes, wind-heat eye diseases (such as acute conjunctivitis), and eye fatigue caused by computer users. Contains flavonoid compounds, which inhibit eye inflammation, mildly assist in lowering intraocular pressure, and can disperse wind-heat in the liver meridian, relieve eye redness, swelling, photophobia and tearing. Longan, used for those who overuse their eyes accompanied by insomnia, forgetfulness, and weak qi and blood. It replenishes blood and nourishes the eyes, and relieves eye fatigue. Overall, liver fire + dry eyes: chrysanthemum + cassia seed + wolfberry (clearing heat + nourishing yin).

[0050] In the present invention, lutein ester, zeaxanthin, astaxanthin, blueberry anthocyanin, Antarctic krill, DHA algae oil, and bilberry extract all have antioxidant properties and are effective for specific diseases (such as AMD and dry eye syndrome). For example: "lutein ester + zeaxanthin + DHA algae oil" is suitable for daily care. High-intensity eye use / early AMD: add astaxanthin + bilberry extract. "Krill oil (provides DHA / EPA) + flaxseed oil (plant-based Omega-3)" is a combination for dry eye syndrome. Collaborative eye protection through different targets (antioxidant, anti-inflammatory, neuroprotective, vascular regulation).

[0051] The trace elements, vitamin A, vitamin B, vitamin C, vitamin E, zinc, copper and niacin in the invention have auxiliary effects in the physical therapy for eye diseases.

[0052] Among them, vitamin A is a key component that constitutes the photoreceptor cells (rhodopsin) of the retina, maintains scotopic vision, and protects the health of the cornea. Deficiency can lead to dry eye, night blindness, and even corneal ulcers.

[0053] Vitamin B prevents optic neuritis. Deficiency may cause beriberi optic neuropathy. It relieves visual fatigue. Deficiency is likely to lead to corneal vascular proliferation and photophobia. B12 is related to the health of the optic nerve. Deficiency may increase the risk of optic neuropathy.

[0054] Vitamin C is a strong antioxidant that neutralizes free radicals, delays cataracts and age-related macular degeneration, promotes collagen synthesis, and maintains the strength of the sclera (which may have an indirect effect on myopia prevention and control).

[0055] Vitamin E protects the retinal cell membrane from oxidative damage, reduces the risks of AMD and cataracts, and synergistically enhances the antioxidant effect with vitamin C.

[0056] Zinc is involved in vitamin A metabolism, helps transport vitamin A from the liver to the retina. The retina (especially the macular area) has a high zinc content. Deficiency may affect dark adaptation ability. The AREDS study shows that the combination of zinc and antioxidants can slow down the progression of AMD. Niacin improves retinal blood flow. Animal studies suggest that it may reduce the risk of glaucoma. Vitamin C + E + zinc + copper + lutein / zeaxanthin) is applicable to mid- and late-stage AMD. The combination of vitamin A + Omega-3 has a better effect and is applicable to dry eye.

[0057] In the present invention, cassia seed, wolfberry, dendrobium, chrysanthemum, and longan, which are both medicine and food, are combined with antioxidants such as lutein ester, zeaxanthin, astaxanthin, blueberry anthocyanin, Antarctic krill, DHA algal oil, and bilberry extract, as well as trace elements such as vitamin A, vitamin B, vitamin C, vitamin E, zinc, copper, and niacin to form a composition. Thus, it can have a certain therapeutic and physiotherapeutic effect on various eye diseases.

[0058] Cassia seed, wolfberry, dendrobium, chrysanthemum, and longan in the present invention are both medicine and food. The pharmacological effects and functions of each component are as follows:

[0059] Lutein ester, zeaxanthin, astaxanthin, blueberry anthocyanin, Antarctic krill, DHA algal oil, and bilberry extract in the present invention are antioxidants, which are specifically described as follows:

[0060] (1) Lutein ester: It has the effects of relieving visual fatigue, protecting the retina, improving visual function, promoting eye health, and antioxidation. It also has the functions of maintaining visual health, improving visual function, protecting the eyes from light damage, promoting blood circulation in the eyes, and enhancing immunity. Lutein ester has the function of filtering blue light, etc., and has a good nutritional effect on the development of the eyes. It can prevent the eyes from being damaged by ultraviolet rays or mobile phone blue light and protect the retina of the eyes.

[0061] Among them: It has the effect of relieving visual fatigue. Prolonged use of electronic devices or reading is likely to cause visual fatigue. Lutein esters can relieve eye fatigue and reduce eye discomfort. Protect the retina: It is the main pigment in the macular area of the retina, which helps to absorb and filter harmful blue light and reduce the damage of light to the retina. Improve visual function: Lutein esters help to improve visual contrast and color sensitivity, making the vision clearer. Promote eye health: It helps to maintain the normal physiological functions of the eyes and has a certain auxiliary effect on preventing eye diseases such as glaucoma and cataracts. Antioxidation: Lutein esters can be converted into lutein in the body, have strong antioxidant ability, can scavenge free radicals in the body, and slow down the aging process of cells. Anti-inflammatory: Lutein esters can inhibit the release of inflammatory factors, reduce the inflammatory response, lower visual sensitivity, relieve eye inflammation caused by eye diseases such as uveitis, and improve discomfort symptoms such as eye redness, pain, and blurred vision.

[0062] (2) Zeaxanthin: It has the effects of antioxidation and relieving visual fatigue, and also has the function of preventing eye diseases.

[0063] Among them: Antioxidation, zeaxanthin has strong antioxidant ability, can neutralize free radicals, and reduce the damage of oxidative stress to cells. Relieve visual fatigue. Such substances have the effect of relieving visual fatigue. If patients have visual fatigue symptoms such as dry eyes and a feeling of foreign body in the eyes, they can supplement such substances appropriately for relief, which can improve the condition to a certain extent, help protect the retina from light damage, and prevent eye diseases such as macular degeneration. Prevent eye diseases. Zeaxanthin can absorb ultraviolet rays in light. Appropriate consumption can protect the eyes, and can also accelerate the metabolism of the eye area, and can prevent eye diseases to a certain extent.

[0064] (3) Astaxanthin: It is an antioxidant and has the effects of antioxidation, anti-aging, and anti-free radicals, etc.

[0065] Among them: Antioxidation: Astaxanthin can neutralize free radicals in the body, reduce the damage of oxidative stress to cells, and has the effects of delaying aging and maintaining health. Protect the eyes: Astaxanthin can protect the retina and macular area of the eyes, thus slowing down eye aging and improving eyesight. Anti-inflammatory: Astaxanthin can help relieve the symptoms of arthritis and can also inhibit the release of chemicals in the inflammatory response, thus reducing the inflammatory response.

[0066] (4) Blueberry anthocyanins: It has antioxidation, anti-inflammatory, protecting eyesight, protecting cardiovascular, immune regulation, etc., and can play roles such as anti-aging, relieving inflammatory diseases, maintaining eyesight health, preventing cardiovascular diseases, preventing infectious diseases, and improving the overall health level of the body.

[0067] Among them: Antioxidant, astaxanthin has antioxidant effects. With its unique molecular structure, it can effectively neutralize free radicals in the body, reduce the damage of oxidative stress to cells, and play a certain role in anti-aging. Anti-inflammatory, astaxanthin has significant anti-inflammatory effects. It can reduce the release of inflammatory mediators and alleviate inflammatory responses, which has a positive effect on relieving the symptoms of inflammatory diseases such as arthritis and joint pain. Protect eyesight, astaxanthin also has the effect of protecting eyesight. It can absorb blue light and protect the retina from light damage, helping to prevent the occurrence of eye diseases such as macular degeneration and cataracts, thus playing a role in maintaining eye health.

[0068] (5) Blueberry anthocyanins: Antioxidant, mitochondria are the main source of ROS in cells. Through the leakage of electrons in the respiratory chain, the accumulation of ROS in mitochondria will lead to the depolarization of the mitochondrial membrane. In high-energy-consuming cells such as cardiomyocytes, the impairment of mitochondrial activity will interfere with glucose and fatty acid metabolism and cause cardiomyopathy. Anthocyanins and their metabolite protocatechuic acid can reduce the concentration of mitochondrial ROS and alleviate the damage. In addition, there are multiple phenolic hydroxyl groups in the structure of blueberry anthocyanins, which can provide hydrogen atoms to combine with free radicals to scavenge free radicals. The aglycone anthocyanin can also scavenge free radicals through electron transfer.

[0069] Improve eyesight, blueberry anthocyanins can effectively protect the microvessels in the eyes, improve blood circulation, and accelerate the regeneration of visual purple. Research by Yang Dan et al. shows that blueberry anthocyanins can regulate the proteins in the PI3K / AKT signaling pathway, reduce the retinal field gray value and macular edema thickness of rats with diabetic retinopathy, and alleviate retinal oxidative stress damage and inflammatory responses. Blueberries are rich in anthocyanins, SOD, vitamins, etc., which can improve blood circulation in the eyes, provide various essential nutrients required by the eyes, maintain eye health, relieve dryness and soreness of the eyes, and reduce eye fatigue.

[0070] (6) Antarctic krill: It contains rich proteins, amino acids, and elements such as calcium, phosphorus, potassium, and sodium required by the human body. It has essential fatty acids that the human body cannot synthesize by itself but are indispensable, and can play a role in brain tonifying and improving eyesight; it is rich in high-quality proteins, various amino acids, and nutrients such as vitamin A and D. These substances have positive effects on enhancing immunity, protecting eyesight, promoting calcium absorption, etc.

[0071] (7) DHA algal oil: Algal oil rich in ω-3 series unsaturated fatty acids, with docosahexaenoic acid as the main component. DHA is an important component of retinal cells, which plays a positive role in maintaining retinal function and preventing eye diseases; DHA has a certain anti-inflammatory effect, can reduce the generation of inflammatory mediators, and may be helpful for the adjuvant treatment of some inflammatory diseases. Promote vision development: DHA is an important component of visual cells. Appropriate supplementation of DHA algal oil can improve the function of visual cells, also improve the fluidity of the retinal cell membrane, accelerate the transmission and processing of visual information, and can promote the vision development of infants or fetuses.

[0072] (8) Bilberry extract: A powerful antioxidant, suitable for most people. Bilberry extract has the following six main functions and effects: Antioxidation Bilberry extract contains rich anthocyanins, which are hydroxyl donors and also a kind of free radical scavenger. It can combine with proteins and jointly prevent peroxidation, thus effectively scavenging excessive oxygen free radicals in the body and achieving the effect of antioxidation. Protect the eyes Bilberry extract has the effect of improving the transmission of oxygen and blood to the eyes. Many eye diseases ultimately result from the damage of free radicals to the eyes, and bilberry extract, as a powerful antioxidant, can protect the eyes from free radical damage. It can also improve night vision acuity and accelerate the speed of dark adaptation.

[0073] The functional effects of the traditional Chinese medicine and food homologous components in the present invention, namely cassia seed, wolfberry fruit, dendrobium, chrysanthemum, and longan, are specifically described as follows:

[0074] (1) Cassia seed: It has the effects of clearing heat and improving eyesight, moistening the intestines and relieving constipation, purging liver fire, dispersing wind and relieving the exterior, and treating diseases, etc. However, cassia seed needs to be taken under the guidance of a doctor.

[0075] Among them: Clearing heat and improving eyesight: Cassia seed is bitter and cold, which can clear heat and improve eyesight, and can be used to treat symptoms such as red, swollen, and painful eyes, photophobia with excessive tearing, and constipation caused by wind-heat attacking upward or liver fire disturbing upward. It can also improve blurred vision and dim eyesight caused by deficiency of liver and kidney yin. Moistening the intestines and relieving constipation: Cassia seed also has the effects of moistening the intestines and relieving constipation, and can effectively improve symptoms such as dry and hard stools and constipation caused by internal heat and intestinal dryness. Purging liver fire: Cassia seed is bitter and cold, and can also play the role of purging liver fire, and can be used to improve dizziness caused by hyperactivity of liver yang. Dispelling wind and relieving the exterior: If cassia seed is brewed and drunk together with mulberry leaf, mint, etc., it can also dispel wind and relieve the exterior, and improve symptoms such as sore throat and dizziness and fatigue caused by common cold.

[0076] (2) Wolfberry fruit: It has the effects of tonifying the liver and kidney, benefiting essence and improving eyesight, enhancing physique, enhancing sexual function, and improving immunity, etc.

[0077] Among them:. Nourishing the liver and kidney: Wolfberry has a good effect of nourishing the liver and kidney. After consumption, it can effectively nourish the liver and kidney, enhance the functions of the liver and kidney, and improve symptoms such as soreness in the waist and knees, dizziness and tinnitus, and internal heat and thirst caused by abnormal liver and kidney. Tonifying essence and improving eyesight: Wolfberry can play the role of tonifying essence and improving eyesight, and has a good nourishing effect on the eyes, which can effectively improve the condition of unclear vision. Strengthening the constitution: Wolfberry has high nutritional and medicinal values, can supplement a variety of nutrients, help the human body strengthen the constitution, and improve symptoms of deficiency of vital essence, emaciation, and sallow complexion due to blood deficiency.. Improving immunity: If wolfberry is eaten in moderation for a long time, it can indirectly improve the human body's immunity while continuously supplementing nutrition.

[0078] (3) Dendrobium officinale: It is a traditional Chinese medicine, and its main effects include nourishing the lungs and yin, lowering blood sugar, improving immunity, antioxidation, and improving digestive function, etc.; its functions include anti-inflammatory, improving sleep, tonifying the kidney and essence, anti-tumor, and protecting eyesight, etc., but it needs to be used under the guidance of a doctor.

[0079] Among them: Protecting eyesight: The active ingredients in Dendrobium officinale have a protective effect on the retina, can relieve eye fatigue and improve eyesight, and have a certain adjuvant effect on eye diseases. Nourishing the lungs and yin: Dendrobium officinale has the effect of nourishing the lung yin and can relieve symptoms such as lung heat, dry cough, and dry throat. Lowering blood sugar: The active ingredients in Dendrobium officinale can promote the secretion of insulin and improve the utilization of glucose by tissues, and have a certain regulatory effect on diabetic patients. Improving immunity: Dendrobium officinale can enhance the immune function of the body, increase disease resistance, and have a certain adjuvant effect on preventing infectious diseases. Antioxidation: Dendrobium officinale contains a variety of antioxidant substances, can inhibit the generation of free radicals, reduce oxidative damage, and have a certain effect on delaying aging and protecting cell health. Improving digestive function: Dendrobium officinale can promote the secretion of digestive juices, enhance gastrointestinal motility, improve digestive function, and relieve problems such as indigestion and stomachache.

[0080] (4) Chrysanthemum: It has the effects of dispersing wind-heat, suppressing liver yang, clearing the liver and improving eyesight, clearing heat and detoxifying, and anti-inflammatory and antibacterial, etc. It is recommended that patients use it under the guidance of a doctor. If there are obvious discomforts in the body, they should seek medical attention in time.

[0081] Among them: Dispersing wind-heat: Chrysanthemum has the effect of dispersing wind-heat and is usually used to relieve symptoms such as fever, cough, and headache caused by wind-heat cold. Suppressing liver yang: Chrysanthemum has the effect of suppressing liver yang. For patients with excessive liver fire who have symptoms such as dizziness and vertigo, chrysanthemum can be used to relieve them. Clearing the liver and improving eyesight: Chrysanthemum has the effect of clearing the liver and improving eyesight. When liver fire attacks upward, patients may have more eye secretions. Soaking chrysanthemum in warm water and drinking it can relieve the symptoms to a certain extent.. Clearing heat and detoxifying: Chrysanthemum has the effect of clearing heat and detoxifying and can be used to treat symptoms of sores and boils to a certain extent.. Anti-inflammatory and antibacterial: After soaking or decocting chrysanthemum in water, it has a certain antibacterial effect and is helpful for anti-inflammatory.

[0082] (5) Longan: It can supplement vitamins, promote digestion, enhance satiety, relieve thirst, protect the skin, etc. Its functions usually include improving vitamin deficiency, indigestion, hunger, dry mouth and tongue, skin dryness, etc.

[0083] Among them: Supplement of vitamins: Longan is rich in vitamin C. Eating an appropriate amount can supplement enough vitamins for the body and help improve vitamin deficiency. Promote digestion: Longan contains a certain amount of dietary fiber, which can increase intestinal peristalsis, help digest food, and achieve the purpose of improving indigestion. Enhance satiety: Longan contains minerals and dietary fiber. Eating an appropriate amount can supplement energy for the body, increase satiety, and achieve the effect of relieving hunger. Relieve thirst: Eating an appropriate amount of longan can help supplement water, maintain the body's water balance, and also help relieve dry mouth and tongue. Protect the skin: The vitamin C contained in longan has the effect of protecting the skin and helps improve skin dryness.

[0084] (6) Spirulina is rich in nutrients such as protein, β-carotene, lutein, phycocyanin, etc. β-carotene can be converted into vitamin A in the body, which helps to maintain the normal function of the cornea and prevent night blindness; lutein can filter blue light and protect the retina from oxidative damage.

[0085] (7) Ginkgo seeds: Contain components such as ginkgo flavonoids, have the effects of antioxidant and improving blood circulation, can provide sufficient oxygen and nutrition for eye tissues, help relieve eye fatigue, and protect eyesight.

[0086] In the present invention, trace elements, vitamins A, B, C, E, zinc, copper, and niacin, their functional effects are specifically described as follows:

[0087] (1) Vitamin A: It has functions such as maintaining visual function, stabilizing epithelial cells, and regulating bone metabolism. Maintaining visual function: Vitamin A is a component of rhodopsin in the retina and can play an important role under light, enabling better vision in low-light environments. It can effectively maintain visual function, enhance night vision, and prevent night blindness.

[0088] (2) Vitamin B: Vitamin B12 is an essential vitamin for the normal function of the nervous system. It participates in the formation of lipoproteins in nerve tissues, helps maintain the metabolism and function of the myelin sheath. It can also promote the repair and conversion of the myelin sheath, improve nerve conduction, and has an adjuvant therapeutic effect on nervous system diseases such as neuritis and nerve atrophy. It has the effects of inducing sleep, improving sleep quality, and reducing the symptoms of dreaminess, and has an improvement effect on mild insomnia. It can relieve discomfort symptoms such as soreness and dryness in the eyes and has a certain protective effect on the eyes.

[0089] (3) Vitamin C: It can enhance immunity, has antioxidant and beauty effects, promotes iron absorption, promotes collagen synthesis, and improves nutrient absorption. Its functions include reducing the incidence of colds, reducing skin melanin deposition, preventing and treating iron deficiency anemia, maintaining the normal structure and function of the human body, and improving the utilization rate of iron by the liver. As a powerful antioxidant, it can scavenge free radicals, prevent the damage of free radicals to the human body, reduce skin melanin deposition, and has the effects of whitening and lightening spots and delaying aging.

[0090] (4) Vitamin E: It has antioxidant, cardiovascular protection, immunity enhancement, human cell protection, and anti-inflammatory effects. Antioxidant: Vitamin E is an important antioxidant that can neutralize free radicals, prevent free radicals from damaging body cells, and helps protect cells and tissues from oxidative damage. Cardiovascular protection: Vitamin E can prevent low-density lipoprotein cholesterol from being oxidized, thereby reducing cholesterol deposition in connective tissues, delaying cardiovascular damage and aging, and thus reducing the risk of cardiovascular diseases. Immunity enhancement: Vitamin E can enhance the body's immunity and help prevent the infection of epidemic diseases. Human cell protection: Vitamin E can protect unsaturated fatty acids in the human body from being damaged by free radicals, and then play a role in protecting internal organs. Anti-inflammatory: Vitamin E can maintain normal immune function, inhibit the proliferation of germs, and play a certain anti-inflammatory role.

[0091] (5) Zinc: One of the essential trace elements in the human body, it mainly plays a variety of physiological functions in the human body, including promoting growth and development, improving taste, enhancing immunity, maintaining skin health, and protecting the eyes.

[0092] Zinc can promote the growth and development of the human body, and has a certain promoting effect on the growth of children's height and weight. In addition, zinc can also promote brain development and improve intelligence levels. Zinc can improve the taste of the human body, increase appetite, and promote the digestion and absorption of food. If the human body is deficient in zinc, symptoms such as loss of appetite and anorexia may occur. Zinc can promote the differentiation of T lymphocytes, enhance cellular immune function, and can also promote the production of antibodies in the body, improving the body's immunity. If the human body is deficient in zinc, the immune function may decline. Zinc can promote skin metabolism and maintain the health of the skin. If the human body is deficient in zinc, symptoms such as dry skin and peeling may occur. Protecting the eyes, zinc can promote the development of the retina in the eyes and maintain eye health. If the human body is deficient in zinc, symptoms such as vision loss and blurred vision may occur.

[0093] (6) Copper: Maintaining proper melanin production: Melanin is a natural dark pigment that helps color the skin, hair, and eyes. Copper is an important component of melanin. Copper can help the body regulate the production of melanin, which helps keep the eyes, hair, and skin looking and feeling healthy. Copper is a powerful antioxidant that can combat free radicals and slow down the aging process. Free radicals can invade cell membranes and cause cell breakdown.

[0094] (7) Niacin: It has functions such as improving blood circulation, maintaining skin health, promoting energy metabolism, nervous system function, and antioxidant effects. Antioxidant effect, niacin also has a certain antioxidant function, which can scavenge free radicals in the body, reduce the damage of oxidative stress to cells, protect cells from damage, and delay the aging process. Improving blood circulation. Niacin has the ability to dilate blood vessels, effectively reduce cholesterol and triglyceride levels, thereby improving blood circulation and preventing cardiovascular diseases.

[0095] Specific Example 1: Preparation process of a composition with the function of supplementing fundus nerve nutrition and having anti-fatigue and antioxidant functions, using the following steps:

[0096] S10: Take 8 parts of cassia seeds, 6 parts of wolfberries, 6 parts of dendrobium, 7 parts of chrysanthemums, 5 parts of longans, 2 parts of spirulina, and 2 parts of ginkgo seeds, add them to a stirring tank, grind them, and add an appropriate amount of distilled water, and stir evenly to form an initial liquid;

[0097] S20: In the initial liquid in step S10, add 0.1 part of vitamin A, 0.2 part of vitamin B, 0.2 part of vitamin C, 0.2 part of vitamin E, 0.2 part of zinc, 0.1 part of copper, 0.3 part of niacin, 0.1 part of glutathione, and 0.2 part of bilberry extract respectively, and then stir evenly through a blender to form a mixed liquid;

[0098] S30: Add 0.5 part of lutein ester, 0.1 part of zeaxanthin, 0.6 part of astaxanthin, 0.3 part of blueberry anthocyanins, 0.4 part of Antarctic krill, and 0.5 part of DHA algal oil to the mixed liquid in step S20, heat and decoct it 3 - 5 times, each time for 20 - 30 minutes, to form a concentrated liquid; then adjust the pH value of the concentrated liquid with a borate buffer solution, and the pH value is between 6.5 and 7.

[0099] S40: Sterilize and can the finished liquid in step S30. Specific Example 2:

[0101] Preparation process of a composition with the function of supplementing fundus nerve nutrition and having anti-fatigue and antioxidant functions, using the following steps:

[0102] S10: Take 10 parts of Japanese wormwood seeds, 7 parts of Chinese wolfberries, 6 parts of dendrobium, 6 parts of chrysanthemums, 4 parts of longans, 3 parts of spirulina, and 3 parts of ginkgo seeds. Add them to a mixing tank, grind them, and add an appropriate amount of distilled water. Stir evenly to form an initial liquid.

[0103] S20: In the initial liquid obtained in step S10, add 0.2 part of vitamin A, 0.3 part of vitamin B, 0.3 part of vitamin C, 0.3 part of vitamin E, 0.4 part of zinc, 0.3 part of copper, 0.5 part of niacin, 0.2 part of glutathione, and 0.3 part of bilberry extract respectively. Then stir evenly with a blender to form a mixed liquid.

[0104] S30: Add 1.5 parts of lutein esters, 0.3 part of zeaxanthin, 0.7 part of astaxanthin, 0.4 part of blueberry anthocyanins, 0.5 part of Antarctic krill, and 0.6 part of DHA algal oil to the mixed liquid obtained in step S20. Heat and decoct it 3 - 5 times, each time for 20 - 30 minutes, to form a concentrated liquid. Then adjust the pH value of the concentrated liquid with borate buffer solution, and the pH value is between 6.5 and 7.

[0105] S40: Sterilize and can the finished product liquid obtained in step S30.

[0106] The experimental data of the present invention are as follows. The subjects are eye fatigue people aged 18 - 65 years with long - term eye use. Symptoms: dry eyes, burning sensation, blurred vision, headache, etc. Time: 8 weeks (short - term experiment).

[0107]

[0108] The present invention is directed to an animal model: mice with retinal ganglion cell (RGC) injury induced by high intraocular pressure / light damage (n = 60, divided into 4 groups), and a cell model: retinal nerve cells cultured in vitro (such as the RGC - 5 cell line).

[0109] Grouping and treatment: Control group: normal saline / normal culture medium; Model group: injury induction + normal saline; Low - dose group: injury induction + composition (50 mg / kg / day); High - dose group: injury induction + composition (100 mg / kg / day).

[0110] Detection indexes: Antioxidant capacity: activities of SOD and GSH - Px, content of MDA; Anti - fatigue: content of retinal ATP, release of lactate dehydrogenase (LDH); Neurotrophic: levels of BDNF and NGF; Cell survival rate: TUNEL staining (apoptosis), CCK - 8 detection.

[0111] Detection index Control group Model group Low-dose group High-dose group SOD (U / mgprot) 120.5±8.2 75.3±6.1 98.7±7.4 110.2±9.6 MDA (nmol / mg) 2.1±0.3 4.8±0.5 3.2±0.4 2.5±0.3 BDNF (pg / ml) 85.6±7.3 42.1±5.2 68.9±6.1 79.4±7.8 Cell survival rate (%) 95.2±3.1 52.7±4.8 76.3±5.2 88.6±4.7

[0112] Results:

[0113] (1) The high-dose group significantly increased the SOD activity (↑46.2% vs. the model group) and decreased the MDA level (↓47.9%), indicating that the composition can relieve oxidative stress.

[0114] (2) Neurotrophic effect: The BDNF level was restored to near the control group (↑88.6% vs. the model group), suggesting promotion of nerve repair.

[0115] (3) Anti-fatigue: The ATP content increased by 35% (data not shown), and the LDH release decreased, indicating improvement of cellular energy metabolism.

[0116] The above is only the preferred embodiment of the present invention. Therefore, all equivalent changes or modifications made according to the features and principles described in the scope of the present invention patent application are included in the scope of the present invention patent application.

Claims

1. A composition for supplementing fundus nerve nutrition and having anti-fatigue and antioxidant functions, with the composition components by weight ratio as follows: Cassia seed 8 - 10 parts, Chinese wolfberry 6 - 8 parts, Dendrobium officinale 6 - 8 parts, Chrysanthemum morifolium 6 - 8 parts, Longan aril 4 - 6 parts, Spirulina 2 - 3 parts, Ginkgo biloba 2 - 3 parts, Vitamin A 0.1 - 0.3 parts, Vitamin B 0.2 - 0.4 parts, Vitamin C 0.2 - 0.5 parts, Vitamin E 0.2 - 0.5 parts, Zinc 0.2 - 0.5 parts, Copper 0.1 - 0.3 parts, Niacin 0.3 - 0.6 parts, Lutein ester 0.5 - 1.5 parts, Zeaxanthin 0.1 - 0.5 parts, Astaxanthin 0.6 - 0.9 parts, Blueberry anthocyanins 0.3 - 0.5 parts, Antarctic krill 0.4 - 0.6 parts, DHA algal oil 0.5 - 0.7 parts, Glutathione 0.1 - 0.3 parts, Bilberry extract 0.2 - 0.4 parts.

2. The composition for supplementing fundus nerve nutrition and having anti-fatigue and anti-oxidation functions according to claim 1, wherein: A composition for supplementing fundus nerve nutrition and having anti-fatigue and antioxidant functions, with the composition components by weight ratio as follows: Cassia seed 8 parts, Chinese wolfberry 6 parts, Dendrobium officinale 6 parts, Chrysanthemum morifolium 7 parts, Longan aril 5 parts, Spirulina 2 parts, Ginkgo biloba 2 parts, Vitamin A 0.1 parts, Vitamin B 0.2 parts, Vitamin C 0.2 parts, Vitamin E 0.2 parts, Zinc 0.2 parts, Copper 0.1 parts, Niacin 0.3 parts, Lutein ester 0.5 parts, Zeaxanthin 0.1 parts, Astaxanthin 0.6 parts, Blueberry anthocyanins 0.3 parts, Antarctic krill 0.4 parts, DHA algal oil 0.5 parts, Glutathione 0.1 parts, Bilberry extract 0.2 parts.

3. The composition for supplementing fundus neurotrophic and having anti-fatigue and antioxidant functions according to claim 1, wherein: A composition for supplementing fundus nerve nutrition and having anti-fatigue and antioxidant functions, with the composition components by weight ratio as follows: Cassia seed 10 parts, Chinese wolfberry 7 parts, Dendrobium officinale 6 parts, Chrysanthemum morifolium 6 parts, Longan aril 4 parts, Spirulina 3 parts, Ginkgo biloba 3 parts, Vitamin A 0.2 parts, Vitamin B 0.3 parts, Vitamin C 0.3 parts, Vitamin E 0.3 parts, Zinc 0.4 parts, Copper 0.3 parts, Niacin 0.5 parts, Lutein ester 1.5 parts, Zeaxanthin 0.3 parts, Astaxanthin 0.7 parts, Blueberry anthocyanins 0.4 parts, Antarctic krill 0.5 parts, DHA algal oil 0.6 parts, Glutathione 0.2 parts, Bilberry extract 0.3 parts.

4. The preparation process of the composition for supplementing fundus nerve nutrition and having anti-fatigue and antioxidant functions adopts the following steps: S10: Take 8 - 10 parts of Cassia seed, 6 - 8 parts of Chinese wolfberry, 6 - 8 parts of Dendrobium officinale, 6 - 8 parts of Chrysanthemum morifolium, 4 - 6 parts of Longan aril, 2 - 3 parts of Spirulina, 2 - 3 parts of Ginkgo biloba, add them into a stirring tank, grind them, and add an appropriate amount of distilled water, then stir evenly to form an initial liquid; S20: In the initial liquid in step S10, add 0.1 - 0.3 parts of Vitamin A, 0.2 - 0.4 parts of Vitamin B, 0.2 - 0.5 parts of Vitamin C, 0.2 - 0.5 parts of Vitamin E, 0.2 - 0.5 parts of Zinc, 0.1 - 0.3 parts of Copper, 0.3 - 0.6 parts of Niacin, 0.1 - 0.3 parts of Glutathione, 0.2 - 0.4 parts of Bilberry extract respectively, and then stir evenly through a blender to form a mixed liquid; S30: Add 0.5 parts of lutein ester, 0.1 part of zeaxanthin, 0.6 part of astaxanthin, 0.3 part of blueberry anthocyanin, 0.4 part of Antarctic krill, and 0.5 part of DHA algal oil to the mixture in step S20, and heat and decoct it 3 - 5 times, 20 - 30 minutes each time, to form a concentrated solution; then adjust the pH value of the solution of the concentrated solution by using borate buffer, and the pH value is between 6.5 and 7.

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