Application of breynia fruticosa extract in preparation of composition for treating bony spur
By removing the Isochoin from the black-faced horse leaves, a non-toxic black-faced horse extract was prepared, which solved the problem of the toxic ingredients of the black-faced horse restricting its application, and achieved safe and effective bone spur treatment.
Patent Information
- Application Number
- CN202410103500.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-01-25
- Publication Date
- 2025-07-25
AI Technical Summary
The toxicity of Isothin contained in black-faced horses limits its application in the treatment of bone spurs and other diseases, and the existing folk prescriptions have safety risks.
By removing the icosone in the black-faced horse leaves, using alcohol extraction or long-term soaking, non-toxic black-faced horse extract is obtained, and compositions for treating bone spurs are prepared in combination with pharmaceutically acceptable thickeners, rose essence, citronella oil and vinegar.
The preparation of non-toxic black horse extract is achieved, safely and effectively treats bone spur diseases, while avoiding discomfort reactions from patients, making it more convenient to use.
Smart Images
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Abstract
Description
Technical Field
[0001] The present invention relates to the use of Plumbago indica, in particular to the use of an extract of Plumbago indica for preparing a composition for treating bone spurs. Background Art
[0002] Plumbago indica is a perennial semi-trailing subshrub of the genus Plumbago in the family Plumbaginaceae. The whole plant is poisonous. The plumbagin (also known as plumbagin) contained therein can cause skin redness, peeling, and ingestion may also cause paralysis and even miscarriage in pregnant women.
[0003] On the other hand, although there are also folk remedies indicating that Plumbago indica can be used to treat traumatic injuries, bone spurs, tinea corporis or snake and insect bites, the toxins contained in its plant body have many limitations in the use of Plumbago indica as a herbal medicine and are difficult to use. Summary of the Invention
[0004] In view of the foregoing problems, the purpose of the present invention is to provide a use of an extract of Plumbago indica for preparing a composition for treating bone spurs, and an extract of Plumbago indica free of toxicity can be obtained for preparing a composition for treating bone spurs.
[0005] To achieve the above object, the present invention provides a use of an extract of Plumbago indica for preparing a composition for treating bone spurs, wherein the extract of Plumbago indica is obtained by removing plumbagin from the plant body of Plumbago indica.
[0006] According to an embodiment of the use of the present invention, the step of removing plumbagin from the plant body of Plumbago indica is as follows:
[0007] A pretreatment step of washing and drying Plumbago indica leaves; and
[0008] An extraction step of immersing the Plumbago indica leaves in alcohol with a concentration of at least 20%, taking out the Plumbago indica leaves and crushing them into a slurry, and then heating the slurry in a water bath for at least 50 hours, and collecting the vapor of the slurry during this period to obtain the extract of Plumbago indica.
[0009] According to an embodiment of the use of the present invention, the step of removing plumbagin from the plant body of Plumbago indica is as follows:
[0010] A pretreatment step of washing and drying Plumbago indica leaves; and
[0011] An extraction step of immersing the Plumbago indica leaves in alcohol with a concentration of at least 20% for at least 6 months and then collecting the alcohol to obtain the extract of Plumbago indica.
[0012] According to an embodiment of the use of the present invention, the bone spurs include pain in the huangmao region, frozen shoulder and rheumatism.
[0013] In one embodiment of the use according to the present invention, the composition further comprises at least one component selected from the group consisting of pharmaceutically acceptable thickeners, rose essence, citronella oil, and vinegar.
[0014] The use of the extract of Securidaca inappendiculata Hassk. according to the present invention for preparing a composition for treating bone spurs can obtain an extract of Securidaca inappendiculata Hassk. with toxicity removed for preparing a composition for treating bone spurs. Detailed implementation manners
[0015] The following describes embodiments of the present invention, but the present invention is not limited thereto.
[0016] In one embodiment of the use of the extract of Securidaca inappendiculata Hassk. according to the present invention for preparing a composition for treating bone spurs, the following steps are performed to remove lapachol in the plant body of Securidaca inappendiculata Hassk.
[0017] First, perform a pretreatment step of washing and then drying the leaves of Securidaca inappendiculata Hassk.
[0018] Through the pretreatment step, dust, microorganisms, and impurities attached to the leaves of Securidaca inappendiculata Hassk. can be removed.
[0019] Next, perform an extraction step. After immersing the leaves of Securidaca inappendiculata Hassk. in alcohol with a concentration of at least 20%, take out the leaves of Securidaca inappendiculata Hassk. and break them into a slurry, and then heat the slurry in a water bath for at least 50 hours. During this period, collect the vapor of the slurry to obtain the extract of Securidaca inappendiculata Hassk.
[0020] Through the extraction step, break the leaves of Securidaca inappendiculata Hassk. to release the components inside, and then through heating the slurry obtained from the broken leaves in a water bath for distillation, make its active ingredients evaporate and separate from the toxic components. Collect its vapor during heating to obtain a non-toxic extract of Securidaca inappendiculata Hassk. that can treat bone spurs.
[0021] In another embodiment of the use of the extract of Securidaca inappendiculata Hassk. according to the present invention for preparing a composition for treating bone spurs, the following steps are performed to remove lapachol in the plant body of Securidaca inappendiculata Hassk.
[0022] First, perform a pretreatment step of washing and then drying the leaves of Securidaca inappendiculata Hassk.
[0023] Through the pretreatment step, dust, microorganisms, and impurities attached to the leaves of Securidaca inappendiculata Hassk. can be removed.
[0024] Next, perform an extraction step. After immersing the leaves of Securidaca inappendiculata Hassk. in alcohol with a concentration of at least 20% for at least 6 months, collect the alcohol to obtain the extract of Securidaca inappendiculata Hassk.
[0025] Through the extraction step, the active ingredients in the leaves of *Securinega suffruticosa* are dissolved in alcohol, separating the active ingredients from the toxic ingredients. By soaking the leaves of *Securinega suffruticosa* in alcohol for at least 6 months and then collecting the alcohol, an effective amount of non-toxic *Securinega suffruticosa* extract that can treat bone spurs can be obtained.
[0026] By the above method, a *Securinega suffruticosa* extract with plumbagin removed from the leaves of *Securinega suffruticosa* is obtained and further used to prepare a composition for treating bone spurs. It can exert the effect of treating bone spurs without having to worry about the toxins originally present in the leaves of *Securinega suffruticosa*, which is more convenient and safe to use.
[0027] In this example, the *Securinega suffruticosa* extract obtained by the above method and the *Securinega suffruticosa* pulp obtained simply by crushing the leaves of *Securinega suffruticosa* are applied to the skin of patients to observe the patients' reactions.
[0028] Experiments were separately conducted on thirty patients using a patch, *Securinega suffruticosa* pulp, and *Securinega suffruticosa* extract alone. The attachment time was 15 minutes, and the reaction results are shown in Table 1.
[0029]
Table 1
[0030]
[0031]
[0032]
[0033] In the experiment, after using the *Securinega suffruticosa* pulp obtained by crushing the leaves of *Securinega suffruticosa*, the skin of the patients at the application site had symptoms of severe burns, stinging pain, redness, swelling, and blistering. However, after using the *Securinega suffruticosa* extract obtained according to the above method, none of the patients had the above abnormal conditions on the skin at the application site.
[0034] From the above results, it can be seen that the *Securinega suffruticosa* extract obtained according to the above method can effectively remove toxicity, avoid discomfort or poisoning of patients while exerting the therapeutic effect, and is more convenient and safe to use.
[0035] In another embodiment of the use of the *Securinega suffruticosa* extract according to the present invention for preparing a composition for treating bone spurs, the composition further comprises at least one ingredient selected from the group consisting of pharmaceutically acceptable thickeners, rose essence, citronella oil, and vinegar.
[0036] By making the composition further comprise at least one ingredient selected from the group consisting of pharmaceutically acceptable thickeners, rose essence, citronella oil, and vinegar, effects such as increasing the viscosity or aroma of the composition can be exerted to assist the therapeutic effect.
[0037] The use of the Securidaca inappendiculata extract according to the present invention for preparing a composition for treating bone spurs can obtain a Securidaca inappendiculata extract with toxicity removed for preparing a composition for treating bone spurs.
[0038] In addition, the present invention is not limited by the foregoing embodiments. The foregoing embodiments are illustrative, and those having a constitution substantially the same as the technical idea described in the claims of the present invention and achieving the same effects are all included in the technical scope of the present invention.
Claims
1. Use of an extract of Bassia latifolia for preparing a composition for treating bone spurs, wherein the extract of Bassia latifolia is obtained by removing plumbagin from the plant body of Bassia latifolia.
2. The use according to claim 1, wherein The steps for removing plumbagin from the plant body of Bassia latifolia are as follows: A pretreatment step of washing the leaves of Bassia latifolia and then drying them; and An extraction step of immersing the leaves of Bassia latifolia in alcohol with a concentration of at least 20%, taking out the leaves of Bassia latifolia and crushing them into a slurry, and then heating the slurry in a water bath for at least 50 hours, during which the vapor of the slurry is collected to obtain the extract of Bassia latifolia.
3. The use according to claim 1, characterized in that, The steps for removing plumbagin from the plant body of Bassia latifolia are as follows: A pretreatment step of washing the leaves of Bassia latifolia and then drying them; and An extraction step of immersing the leaves of Bassia latifolia in alcohol with a concentration of at least 20% for at least 6 months and then collecting the alcohol to obtain the extract of Bassia latifolia.
4. The use according to claim 1, wherein The composition further comprises at least one component selected from the group consisting of pharmaceutically acceptable thickeners, rose essence, and citronella oil.