Multi-effect collagen composition suitable for sensitive skin and application thereof

Abstract

The invention relates to the technical field of daily chemicals, in particular to a collagen composition suitable for sensitive skin and having multiple effects and application of the collagen composition. The composition comprises the following components: a haw fruit extract, a ginseng root extract, an artemisia annua extract and a centella asiatica extract. The collagen face cream with multiple effects on sensitive skin provided by the invention is mild and skin-friendly, is suitable for people with sensitive skin, selects a low-irritation emulsification system and high-skin-friendly grease, does not contain alcohol, sensitization essence and high-sensitization preservative, has the pH value regulated between 5.2 and 6.0, is close to the slightly acidic environment of human skin, and has the advantages of mild skin-friendly effect, mild skin-friendly effect and good skin-care effect. The irritation and burden on sensitive skin are effectively reduced.

Description

Technical Field

[0001] The present invention relates to the field of daily chemical technology, and particularly relates to a collagen composition with multiple effects suitable for sensitive skin and its application. Background Art

[0002] With the influence of multiple factors such as environmental pollution, irregular work and rest, and increasing stress, the phenomenon of skin sensitization in the modern population has become increasingly common. Sensitive skin is characterized by a decline in skin barrier function and is prone to discomfort symptoms such as stinging, redness, dryness, and itching when exposed to external stimuli. Relevant research shows that about 40% - 60% of the population has varying degrees of skin sensitivity problems, which are particularly common in Asian populations. Therefore, the demand for skin care products for sensitive skin is increasing day by day.

[0003] Currently, most skin care products for sensitive skin on the market mainly focus on basic moisturizing and soothing anti - inflammation, and rarely have multiple skin care effects such as deep repair, anti - aging, barrier enhancement, and elasticity improvement. On the other hand, while ordinary skin care products meet a single effect, they often cause further burden on sensitive skin due to complex ingredient systems, improper compatibility, or residual irritation problems.

[0004] Collagen, as an important structural protein in the dermis of the human skin, has good moisturizing, firming, repairing, and anti - wrinkle functions and is widely used in anti - aging skin care products. However, due to poor penetration ability, the skin care effect of macromolecular collagen is limited in actual use; while small - molecule collagen peptides or amino acid hydrolysates often have problems of thermal instability, easy oxidation or inactivation when retaining their biological activity, especially with poor stability in oil - containing or multi - functional compatibility systems.

[0005] At the same time, sensitive skin faces the following technical challenges when using multi - functional creams:

[0006] Poor compatibility stability: Multiple active ingredients (such as polypeptides, plant extracts, ceramides, etc.) are prone to physical or chemical instability phenomena in the same system;

[0007] High requirements for the emulsification system: It is necessary to balance mildness and occlusive moisturizing, and traditional emulsification systems are difficult to stabilize complex multi - phase systems;

[0008] Poor long - term storage stability: Heat, light, oxygen, etc. are likely to cause degradation of active substances, affecting the product efficacy;

[0009] Functions are prone to interference with each other: For example, antioxidants combine with metal ions, and peptides degrade in an acidic environment.

[0010] Therefore, the development of a mild, safe, and suitable for sensitive skin collagen cream with multiple functions such as moisturizing, repairing, anti-aging, and soothing, and capable of maintaining good compatibility stability and storage stability in a complex ingredient system has become an important research direction and practical application requirement in the current technical field. Summary of the Invention

[0011] To solve the above technical problems, the present invention provides a collagen composition suitable for sensitive skin with multiple effects. The components of the composition include: fructus crataegi extract, ginseng root extract, artemisia annua extract, and centella asiatica extract.

[0012] As an embodiment of the present invention, the composition further includes oat β-glucan.

[0013] As an embodiment of the present invention, the composition further includes panthenol, sodium lactate, and betaine.

[0014] As an embodiment of the present invention, the composition further includes a polypeptide composition.

[0015] The present invention also provides a collagen skin care product suitable for sensitive skin with multiple effects, and the preparation raw materials include the above-mentioned collagen composition.

[0016] As an embodiment of the present invention, the preparation raw materials of the skin care product include:

[0017] 50% - 80% water, 1% - 5% butylene glycol, 0.04% - 0.2% oat (AVENA SATIVA) β - glucan, 0.05% - 2% 1,2 - hexanediol, 0.005% - 0.03% caprylyl glycol, 2% - 8% glycereth - 26, 0.5% - 2% behenyl alcohol, 0.5% - 3% phytosterols, 0.4% - 1.5% cetyl alcohol, 0.5% - 2% stearyl alcohol, 0.01% - 0.1% hydrogenated lecithin, 1% - 5% triglyceride caprylic / capric acid, 2% - 8% glycerin, 0.0005% - 0.002% acetic acid, 0.1% - 1% collagen, 1% - 5% betaine, 1% - 5% dimethicone, 0.005% - 0.3% palmitoyl tripeptide - 5, 0.01% - 0.05% carbomer, 0.01% - 0.05% sodium lactate, 0.005% - 0.02% polysorbate - 20, 0.0001% - 0.001% palmitoyl tripeptide - 1, 0.00001% - 0.001% palmitoyl tetrapeptide - 7, 0.5% - 3% squalane, 0.5% - 2% dipropylene glycol, 0.1% - 0.5% fruit extract of single - fruit hawthorn (CRATAEGUS MONOGYNA), 0.01% - 0.1% root extract of ginseng (PANAX GINSENG), 0.01% - 0.1% extract of sweet wormwood (ARTEMISIA ANNUA), 0.5% - 3% panthenol, 0.5% - 2% copolymer of hydroxyethyl acrylate / sodium acryloyldimethyltaurate, 0.02% - 0.2% sorbitan isostearate, 0.5% - 2% p - hydroxyacetophenone, 0.2% - 1% copolymer of acryloyldimethyltaurine ammonium / VP, 0.1% - 0.5% 3 - O - ethyl ascorbic acid, 0.01% - 0.05% phosphatidylcholine, 0.0005% - 0.002% tocopheryl acetate, 0.0005% - 0.002% ethoxydiglycol, 0.0005% - 0.002% ceramide NS / ceramide NG, 0.0001% - 0.001% ceramide NP, 0.0001% - 0.001% ceramide AP, 0.05% - 0.2% fermentation product of Thermus thermophilus, 0.02% - 0.2% leaf extract of centella asiatica (CENTELLA ASIATICA), 0.00001% - 1% collagen amino acids, 0.01% - 0.5% xanthan gum, 0.01% - 0.5% sodium hyaluronate, 0.005% - 0.5% inulin, 0.0001% - 0.01% α - glucan oligosaccharide, 0.001% - 0.2% soluble collagen.

[0018] As an embodiment of the present invention, the preparation raw materials of the skin care product include:

[0019] Water 51.481%, Butylene Glycol 1%, Oat (AVENA SATIVA) β-Glucan 0.15%, 1,2-Hexanediol 1.6%, Caprylyl Glycol 0.03%, Glycereth-26 6%, Behenyl Alcohol 2%, Phytosterols 2%, Cetyl Alcohol 1%, Stearyl Alcohol 1%, Hydrogenated Lecithin 0.05%, Caprylic / Capric Triglyceride 4%, Glycerin 6.5%, Acetic Acid 0.001%, Collagen 0.55%, Betaine 5%, Dimethicone 5%, Palmitoyl Tripeptide-5 0.03%, Carbomer 0.05%, Sodium Lactate 0.05%, Polysorbate-20 0.015%, Palmitoyl Tripeptide-1 0.001%, Palmitoyl Tetrapeptide-7 0.001%, Squalane 3%, Dipropylene Glycol 1.5%, Monogyna Hawthorn (CRATAEGUS MONOGYNA) Fruit Extract 0.2%, Ginseng (PANAX GINSENG) Root Extract 0.1%, Artemisia Annua (ARTEMISIA ANNUA) Extract 0.1%, Panthenol 2%, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer 1.3%, Sorbitan Isostearate 0.1%, p-Hydroxyacetophenone 1.1%, Ammonium Acryloyldimethyltaurate / VP Copolymer 1%, 3-O-Ethyl Ascorbic Acid 0.25%, Phosphatidylcholine 0.026%, Tocopheryl Acetate 0.002%, Ethoxydiglycol 0.002%, Ceramide NS / Ceramide NG 0.002%, Ceramide NP 0.001%, Ceramide AP 0.001%, Thermus Thermophilus (THERMUS THERMOPHILLUS) Fermentation Product 0.2%, Asiatic Pennywort (CENTELLA ASIATICA) Leaf Extract 0.15%, Collagen Amino Acids 0.5%, Xanthan Gum 0.2%, Sodium Hyaluronate 0.1%, Inulin 0.5%, α-Glucan Oligosaccharide 0.007%, Soluble Collagen 0.15%.

[0020] The present invention provides a preparation method of the skin care product, and the steps are as follows:

[0021] (1) Preparation of the aqueous phase

[0022] a. Take a clean container, mix Carbomer and xanthan gum evenly with dipropylene glycol, and disperse them with a homogenizer (8000 rpm) for 5 minutes to form a particle-free paste.

[0023] b. Add purified water to the reaction kettle, heat it to 65 - 70 °C, set the stirring speed at 150 - 200 rpm, and stir.

[0024] c. Add 1,2-ethylene glycol, glycereth-26, polysorbate-20, and ethoxydiglycol to the reaction kettle, and stir for about 5 minutes until completely miscible.

[0025] d. Add glycerol, betaine, and α-glucooligosaccharide into the reaction kettle and stir for about 10 minutes until completely dissolved.

[0026] e. Finally, add sodium lactate and stir for about 3 minutes.

[0027] f. Visually inspect that the solution should be transparent and free of impurities.

[0028] g. Pass the pre-dispersed carbomer / xanthan gum paste through a 100-mesh filter screen and slowly add it into the reaction kettle. At the same time, increase the rotation speed to 300 - 400 rpm and continuously stir for 10 minutes.

[0029] h. Add the copolymer of hydroxyethyl acrylate / sodium acryloyldimethyltaurate and the copolymer of ammonium acryloyldimethyltaurate / VP into the reaction kettle and stir at 150 - 200 rpm for 10 minutes continuously.

[0030] i. Keep the temperature at 65 - 70 °C for standby.

[0031] (2) Preparation of oil phase

[0032] a. Add behenyl alcohol into the oil phase reaction kettle, start stirring (80 - 120 rpm), and heat to 75 - 80 °C.

[0033] b. After behenyl alcohol is completely melted, add stearyl alcohol, sorbitan isostearate, and tocopheryl acetate, and continue to stir for 5 - 10 minutes until completely dissolved.

[0034] c. Cool down to 70 - 75 °C, add cetyl alcohol and phytosterols, and continuously stir until completely dissolved.

[0035] d. Cool down to 65 - 70 °C, add triglyceride caprylic / capric acid and polydimethylsiloxane, increase the stirring speed to 150 - 200 rpm, and stir for 10 - 15 minutes to ensure that all components of the oil phase are fully miscible (which can be judged by observing whether the liquid surface is stratified).

[0036] e. Cool down to 60 - 65 °C, add p-hydroxyacetophenone, and stir (150 - 200 rpm) until completely dissolved.

[0037] f. Add caprylyl glycol, stir for 5 minutes, and then add hydrogenated lecithin, and stir (150 - 200 rpm) until completely dissolved.

[0038] g. Dip a glass rod into the oil phase, and if there is no obvious solid particle residue after cooling, it is regarded as completely melted.

[0039] h. Filter the oil phase through a 100-mesh filter screen.

[0040] i. Keep the temperature of the filtered oil phase at 60 - 65 °C, maintain stirring at 50 rpm, and set aside for use.

[0041] (3) Pre-dispersion of thermosensitive components

[0042] a. Pre-disperse collagen with butylene glycol at a temperature ≤ 30°C.

[0043] b. Pre-dissolve palmitoyl tripeptide-5, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-7 with dipropylene glycol at a temperature of 2 - 10°C.

[0044] c. Pre-dissolve ceramide (NS / NG / NP / AP) with squalane at a temperature ≤ 30°C.

[0045] d. Pre-dissolve panthenol, inulin, oat β-glucan, plant extracts (monocarp hawthorn, ginseng, artemisia annua, asiatic pennywort), etc. with purified water at a temperature ≤ 40°C.

[0046] e. Pre-swelling of sodium hyaluronate with purified water at a temperature ≤ 40°C.

[0047] f. Pre-dissolve soluble collagen and collagen amino acids with purified water at a temperature ≤ 30°C.

[0048] g. Pre-dissolve 3-O-ethyl ascorbic acid with purified water at a temperature ≤ 30°C.

[0049] h. Pre-dissolve the fermentation product of Thermus thermophilus with purified water at a temperature ≤ 30°C.

[0050] (4) Emulsification of the material

[0051] a. Primary emulsification: Slowly pump the oil phase into the water phase while stirring (100 - 200 rpm) to form a primary emulsion.

[0052] b. High-shear homogenization: Turn on the high-shear emulsifier (rotation speed 2000 - 3000 rpm) and homogenize for 10 - 15 minutes to ensure uniform dispersion of oil droplets (monitor the temperature during the process and ensure it does not exceed 65°C. If necessary, turn on the jacket water cooling).

[0053] c. Heat preservation and ripening: Maintain the temperature at 60 - 65°C and continue stirring (300 - 500 rpm) for 15 - 20 minutes.

[0054] (5) Cooling and addition of thermosensitive components

[0055] a. Lower the temperature to 50 - 55°C through jacket circulating water, turn off the circulation, and let it stand for 5 minutes.

[0056] b. Continuously cool down to 45 - 50 °C, and add pre-dispersed panthenol, inulin, oat β-glucan, plant extracts (Crataegus monogyna, Panax ginseng, Artemisia annua, Centella asiatica) and phosphatidylcholine to the base material, and stir at low speed (200 - 300 rpm) for 10 minutes until evenly dispersed.

[0057] c. Continuously cool down to 45 - 50 °C, and add dispersed sodium hyaluronate, soluble collagen, and collagen amino acids to the base material, and stir at low speed (200 - 300 rpm) for 10 minutes until evenly dispersed.

[0058] d. Continuously cool down to ≤40 °C, and add the fermentation product of Thermus thermophilus, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, ceramides (NS / NG / NP / AP), and collagen to the base material, and stir at low speed (200 - 300 rpm) for 5 minutes.

[0059] e. Finally, add 3 - O - ethyl ascorbic acid to the base material.

[0060] f. Adjust the pH to 5.6 - 6.5 with acetic acid.

[0061] (6) Vacuum degassing

[0062] Turn on the vacuum degassing system (-0.08 MPa), with a rotation speed of 100 - 200 rpm, and degas for 10 - 15 minutes.

[0063] (7) Cooling and filling

[0064] Cool to room temperature, and after passing the inspection, filter and fill with a 200 - mesh filter.

[0065] As an embodiment of the present invention, the skin care product is a cream or an emulsion.

[0066] As an embodiment of the present invention, the collagen composition is applied to the daily chemical field.

[0067] By adopting the above technical solutions, the present invention has the following beneficial effects:

[0068] The collagen cream for sensitive skin with multiple effects provided by the present invention has the following beneficial effects:

[0069] 1. Gentle and skin-friendly, suitable for people with sensitive skin: The present invention selects a low-irritation emulsification system and highly skin-friendly oils, does not add alcohol, sensitizing fragrances, and highly sensitizing preservatives, and the pH value is regulated between 5.2 and 6.0, close to the slightly acidic environment of the human skin, effectively reducing the irritation and burden on sensitive skin.

[0070] 2. Synergistic effects of multiple functions: This cream is rich in small molecule collagen, hydrolyzed collagen, peptides (such as palmitoyl tripeptide, tetrapeptide), and various plant soothing and repairing ingredients (such as centella asiatica, ginseng, hawthorn, etc.). On the basis of moisturizing, it has multiple functions such as repairing the barrier, antioxidant and anti-inflammatory, firming and reducing wrinkles, and enhancing elasticity, which can meet the balance of multiple skin care needs of sensitive skin in a vulnerable state.

[0071] 3. High-stability compounding system: By optimizing the step-by-step feeding sequence of the oil phase - water phase and the temperature-controlled emulsification process, the physical and chemical stability between various functional ingredients is ensured, avoiding degradation, precipitation or mutual interference between ingredients, and improving the overall stability of the formulation system.

[0072] 4. Good thermal stability of active substances and long storage period: This invention adopts a specific temperature control process and a light-proof and antioxidant system (such as tocopheryl acetate, hydroxyacetophenone, ethyl ascorbic acid, etc.), which can effectively protect heat-sensitive active ingredients from being damaged by high temperature or light. The product can maintain good sensory properties and functionality under normal temperature storage conditions.

[0073] 5. Excellent skin feel and high use comfort: The multiple emollients and high-molecular conditioners in the formula work synergistically to form a soft and smooth skin feel film layer. The touch is light and non-greasy. After use, the skin has a soft and refreshing feeling, and the user experience is excellent.

[0074] 6. Enhance skin barrier function: The structural lipid components such as ceramide NS, NP, AP, and phosphatidylcholine contained can supplement skin lipids, synergistically promote the repair of the stratum corneum, and significantly improve the skin's own tolerance and the ability to resist external stimuli. BRIEF DESCRIPTION OF THE DRAWINGS

[0075] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following will briefly introduce the drawings required for the description of the specific embodiments or the prior art. Obviously, the drawings in the following description are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0076] The photographed areas for flushing and brightening are the whole face, the photographed area for roughness is the cheek, the photographed position for wrinkles is the outer canthus of the eye, and the photographed area for the mandibular margin angle is the facial mandibular side angle.

[0077] The skin of the exposed measurement area of the subject is balanced for 20 minutes in an environment with a temperature of 20 - 22 °C and a humidity of 40 - 60%, and then the skin is measured using a facial imaging system (VISIA, Canfield, USA).

[0078] Figure 1 Photo of improved flushing

[0079] Figure 2 Brighten and improve photos

[0080] Figure 3 Wrinkle improvement photos

[0081] Figure 4 Roughness improvement photos

[0082] Figure 5 Jawline angle improvement photos. Detailed implementation manners

[0083] The present invention will be further explained and illustrated below in conjunction with specific implementation manners.

[0084] The claims of the present invention will be further elaborated below in conjunction with specific implementation manners.

[0085] Example 1

[0086] A facial cream, comprising the following ingredients (by weight percentage): butylene glycol 1%, oat (AVENA SATIVA) β-glucan 0.15%, 1,2-hexanediol 1.6%, caprylyl glycol 0.03%, glycerol polyether-26 6%, behenyl alcohol 2%, phytosterols 2%, cetyl alcohol 1%, stearyl alcohol 1%, hydrogenated lecithin 0.05%, caprylic / capric triglyceride 4%, glycerol 6.5%, acetic acid 0.001%, collagen 0.55%, betaine 5%, polydimethylsiloxane 5%, palmitoyl tripeptide-5 0.03%, carbomer 0.05%, sodium lactate 0.05%, polysorbate-20 0.015%, palmitoyl tripeptide-1 0.001%, palmitoyl tetrapeptide-7 0.001%, squalane 3%, dipropylene glycol 1.5%, single-fruit hawthorn (CRATAEGUS MONOGYNA) fruit extract 0.2%, ginseng (PANAX GINSENG) root extract 0.1%, artemisia annua (ARTEMISIA ANNUA) extract 0.1%, panthenol 2%, acryloyldimethyltaurate / VP copolymer 1.3%, sorbitan isostearate 0.1%, hydroxyacetophenone 1.1%, acryloyldimethylammonium taurate / VP copolymer 1%, 3-O-ethyl ascorbic acid 0.25%, phosphatidylcholine 0.026%, tocopheryl acetate 0.002%, ethoxydiglycol 0.002%, ethoxydiglycol 0.002%, ceramide NS / ceramide NG 0.002%, ceramide NP 0.001%, ceramide AP 0.001%, Thermus thermophilus fermentation product 0.2%, centella asiatica (CENTELLA ASIATICA) leaf extract 0.15%, collagen amino acids 0.5%, xanthan gum 0.2%, sodium hyaluronate 0.1%, inulin 0.5%, α-glucooligosaccharide 0.007%, soluble collagen 0.15%, and water is made up to 100%.

[0087] The preparation method of the facial cream comprises the following steps:

[0088] (1) Preparation of the aqueous phase

[0089] a. Take a clean container, mix carbomer and xanthan gum with dipropylene glycol evenly, and disperse them with a homogenizer (8000 rpm) for 5 minutes to form a particle-free paste.

[0090] b. Add purified water to the reaction kettle, heat it to 65-70 °C, set the stirring speed at 150-200 rpm, and stir.

[0091] c. Add 1,2-ethylene glycol, glycerol polyether-26, polysorbate-20, and ethoxydiglycol to the reaction kettle, and stir for about 5 minutes until completely miscible.

[0092] d. Add glycerin, betaine, and α-glucooligosaccharide into the reaction kettle and stir for about 10 minutes until completely dissolved.

[0093] e. Finally, add sodium lactate and stir for about 3 minutes.

[0094] f. Visually inspect that the solution should be transparent and free of impurities.

[0095] g. Pass the pre-dispersed carbomer / xanthan gum paste through a 100-mesh filter screen and slowly add it into the reaction kettle. At the same time, increase the rotation speed to 300 - 400 rpm and continuously stir for 10 minutes.

[0096] h. Add the copolymer of hydroxyethyl acrylate / sodium acryloyldimethyltaurate and the copolymer of ammonium acryloyldimethyltaurate / VP into the reaction kettle, stir at 150 - 200 rpm, and continuously stir for 10 minutes.

[0097] i. Keep the temperature at 65 - 70 °C for standby.

[0098] (2) Preparation of the oil phase

[0099] a. Add behenyl alcohol into the oil-phase reaction kettle, start stirring (80 - 120 rpm), and heat to 75 - 80 °C.

[0100] b. After the behenyl alcohol is completely melted, add stearyl alcohol, sorbitan isostearate, and tocopheryl acetate, and continue to stir for 5 - 10 minutes until completely dissolved.

[0101] c. Cool down to 70 - 75 °C, add cetyl alcohol and phytosterols, and continuously stir until completely dissolved.

[0102] d. Cool down to 65 - 70 °C, add triglyceride caprylate / caprate and polydimethylsiloxane, increase the stirring speed to 150 - 200 rpm, and stir for 10 - 15 minutes to ensure that all components of the oil phase are fully miscible (it can be judged by observing whether the liquid surface is layered).

[0103] e. Cool down to 60 - 65 °C, add p-hydroxyacetophenone, and stir (150 - 200 rpm) until completely dissolved.

[0104] f. Add caprylyl glycol, stir for 5 minutes, and then add hydrogenated lecithin, and stir until (150 - 200 rpm) until completely dissolved.

[0105] g. Dip a glass rod into the oil phase, and after cooling, observe that there is no obvious solid particle residue, which is regarded as completely melted.

[0106] h. Filter the oil phase through a 100-mesh filter screen.

[0107] i. Keep the filtered oil phase at a temperature of 60 - 65 °C and maintain stirring at 50 rpm for later use.

[0108] (3) Pre - dispersion of thermosensitive components

[0109] a. Pre - disperse collagen with butylene glycol at a temperature ≤ 30 °C.

[0110] b. Pre - dissolve palmitoyl tripeptide - 5, palmitoyl tripeptide - 1, palmitoyl tetrapeptide - 7 with dipropylene glycol at a temperature of 2 - 10 °C.

[0111] c. Pre - dissolve ceramide (NS / NG / NP / AP) with squalane at a temperature ≤ 30 °C.

[0112] d. Pre - dissolve panthenol, inulin, oat β - glucan, plant extracts (monocot hawthorn, ginseng, artemisia annua, asiatic pennywort) etc. with purified water at a temperature ≤ 40 °C.

[0113] e. Pre - swell sodium hyaluronate with purified water at a temperature ≤ 40 °C.

[0114] f. Pre - dissolve soluble collagen and collagen amino acids with purified water at a temperature ≤ 30 °C.

[0115] g. Pre - dissolve 3 - O - ethyl ascorbic acid with purified water at a temperature ≤ 30 °C.

[0116] h. Pre - dissolve the fermentation product of Thermus thermophilus with purified water at a temperature ≤ 30 °C.

[0117] (4) Emulsification of the material

[0118] a. Primary emulsification: Slowly pump the oil phase into the water phase while stirring (100 - 200 rpm) to form a primary emulsion.

[0119] b. High - shear homogenization: Turn on the high - shear emulsifier (rotation speed 2000 - 3000 rpm) and homogenize for 10 - 15 min to ensure uniform dispersion of oil droplets (monitor the temperature during the process and do not exceed 65 °C, turn on the jacket water cooling if necessary).

[0120] c. Heat preservation and ripening: Keep the temperature at 60 - 65 °C and continue stirring (300 - 500 rpm) for 15 - 20 minutes.

[0121] (5) Cooling and addition of thermosensitive components

[0122] a. Lower the temperature to 50 - 55 °C through jacket - circulated water, turn off the circulation, and let it stand for 5 minutes.

[0123] b. Continue to cool down to 45 - 50 °C, and add pre-dispersed panthenol, inulin, oat β-glucan, plant extracts (Crataegus monogyna, Panax ginseng, Artemisia annua, Centella asiatica) and phosphatidylcholine into the material, and stir at low speed (200 - 300 rpm) for 10 minutes until evenly dispersed.

[0124] c. Continue to cool down to 45 - 50 °C, and add dispersed sodium hyaluronate, soluble collagen, collagen amino acids into the material, and stir at low speed (200 - 300 rpm) for 10 minutes until evenly dispersed.

[0125] d. Continue to cool down to ≤40 °C, and add the fermentation product of Thermus thermophilus, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, ceramide (NS / NG / NP / AP), collagen into the material, and stir at low speed (200 - 300 rpm) for 5 minutes.

[0126] e. Finally, add 3-O-ethyl ascorbic acid into the material.

[0127] f. Adjust the pH to 5.6 - 6.5 with acetic acid.

[0128] (6) Vacuum degassing

[0129] Turn on the vacuum degassing system (-0.08 MPa), rotate at 100 - 200 rpm, and degas for 10 - 15 minutes.

[0130] (7) Cooling and filling

[0131] Cool to room temperature, and after passing the inspection, filter and fill with a 200-mesh filter screen.

[0132] Example 2

[0133] A facial cream, comprising the following ingredients (by weight percentage): butylene glycol 2%, oat (AVENA SATIVA) β-glucan 0.08%, 1,2-hexanediol 1%, caprylyl glycol 0.005%, glycerol polyether-26 3%, behenyl alcohol 0.5%, phytosterols 0.5%, cetyl alcohol 0.5%, stearyl alcohol 2%, hydrogenated lecithin 0.01%, caprylic / capric triglyceride 2%, glycerin 4%, acetic acid 0.005%, collagen 0.1%, betaine 1%, polydimethylsiloxane 4%, palmitoyl tripeptide-5 0.005%, carbomer 0.01%, sodium lactate 0.03%, polysorbate-20 0.02%, palmitoyl tripeptide-1 0.001%, palmitoyl tetrapeptide-7 0.001%, squalane 1%, dipropylene glycol 2%, single-fruit hawthorn (CRATAEGUS MONOGYNA) fruit extract 0.5%, ginseng (PANAX GINSENG) root extract 0.1%, Artemisia annua (ARTEMISIA ANNUA) extract 0.05%, panthenol 3%, acryloyldimethyltaurate / VP copolymer 2%, sorbitan isostearate 0.2%, hydroxyacetophenone 2%, acryloyldimethyltaurine ammonium / VP copolymer 1%, 3-O-ethyl ascorbic acid 0.5%, phosphatidylcholine 0.05%, tocopheryl acetate 0.001%, ethoxydiglycol 0.0015%, ethoxydiglycol 0.002%, ceramide NS / ceramide NG 0.002%, ceramide NP 0.001%, ceramide AP 0.005%, Thermus thermophilus (THERMUSTHERMOPHILLUS) fermentation product 0.05%, centella asiatica (CENTELLA ASIATICA) leaf extract 0.2%, collagen amino acids 1%, xanthan gum 0.5%, sodium hyaluronate 0.5%, inulin 0.3%, α-glucan oligosaccharide 0.01%, soluble collagen 0.001%, and water is added up to 100%.

[0134] The preparation method of the facial cream comprises the following steps:

[0135] (1) Preparation of the aqueous phase

[0136] a. Take a clean container, mix carbomer and xanthan gum with dipropylene glycol evenly, and disperse them with a homogenizer (8000 rpm) for 5 minutes to form a particle-free paste.

[0137] b. Add purified water to the reaction kettle, heat it to 65-70 °C, set the stirring speed at 150-200 rpm, and stir.

[0138] c. Add 1,2-ethylene glycol, glycerol polyether-26, polysorbate-20, and ethoxydiglycol to the reaction kettle, and stir for about 5 minutes until completely miscible.

[0139] d. Add glycerin, betaine, and α-glucooligosaccharide into the reaction kettle and stir for about 10 minutes until completely dissolved.

[0140] e. Finally, add sodium lactate and stir for about 3 minutes.

[0141] f. Visually inspect that the solution should be transparent and free of impurities.

[0142] g. Slowly add the pre-dispersed carbomer / xanthan gum paste through a 100-mesh filter into the reaction kettle, while increasing the rotation speed to 300 - 400 rpm and continuously stirring for 10 minutes.

[0143] h. Add the copolymer of hydroxyethyl acrylate / sodium acryloyldimethyltaurate and the copolymer of ammonium acryloyldimethyltaurate / VP into the reaction kettle, stir at 150 - 200 rpm, and continuously stir for 10 minutes.

[0144] i. Keep the temperature at 65 - 70 °C for standby.

[0145] (2) Preparation of the oil phase

[0146] a. Add behenyl alcohol into the oil phase reaction kettle, start stirring (80 - 120 rpm), and heat to 75 - 80 °C.

[0147] b. After behenyl alcohol is completely melted, add stearyl alcohol, sorbitan isostearate, and tocopheryl acetate, and continue to stir for 5 - 10 minutes until completely dissolved.

[0148] c. Cool down to 70 - 75 °C, add cetyl alcohol and phytosterols, and continuously stir until completely dissolved.

[0149] d. Cool down to 65 - 70 °C, add triglyceride caprylate / caprate and polydimethylsiloxane, increase the stirring speed to 150 - 200 rpm, and stir for 10 - 15 minutes to ensure that all components of the oil phase are fully miscible (which can be judged by observing whether the liquid surface is stratified).

[0150] e. Cool down to 60 - 65 °C, add p-hydroxyacetophenone, and stir (150 - 200 rpm) until completely dissolved.

[0151] f. Add caprylyl glycol, stir for 5 minutes, and then add hydrogenated lecithin, and stir until (150 - 200 rpm) until completely dissolved.

[0152] g. Dip a glass rod into the oil phase, and after cooling, observe that there is no obvious solid particle residue, which is regarded as completely melted.

[0153] h. Filter the oil phase through a 100-mesh filter.

[0154] i. The filtered oil phase is maintained at a temperature of 60 - 65 °C and stirred at 50 rpm for later use.

[0155] (3) Pre-dispersion of heat-sensitive components

[0156] a. The collagen is pre-dispersed with butylene glycol at a temperature ≤ 30 °C.

[0157] b. Palmitoyl tripeptide-5, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-7 are pre-dissolved with dipropylene glycol at a temperature of 2 - 10 °C.

[0158] c. Ceramide (NS / NG / NP / AP) is pre-dissolved with squalane at a temperature ≤ 30 °C.

[0159] d. Panthenol, inulin, oat β-glucan, plant extracts (monocotyledonous hawthorn, ginseng, Artemisia annua, centella asiatica), etc. are pre-dissolved with purified water at a temperature ≤ 40 °C.

[0160] e. Sodium hyaluronate is pre-swollen with purified water at a temperature ≤ 40 °C.

[0161] f. Soluble collagen and collagen amino acids are pre-dissolved with purified water at a temperature ≤ 30 °C.

[0162] g. 3-O-ethyl ascorbic acid is pre-dissolved with purified water at a temperature ≤ 30 °C.

[0163] h. The fermentation product of Thermus thermophilus is pre-dissolved with purified water at a temperature ≤ 30 °C.

[0164] (4) Emulsification of the formulation

[0165] a. Primary emulsification: The oil phase is slowly pumped into the water phase while stirring (100 - 200 rpm) to form a primary emulsion.

[0166] b. High-shear homogenization: Turn on the high-shear emulsifier (rotation speed 2000 - 3000 rpm) and homogenize for 10 - 15 min to ensure uniform dispersion of oil droplets (monitor the temperature during the process and do not exceed 65 °C, turn on the jacket water cooling if necessary).

[0167] c. Heat preservation and ripening: Maintain the temperature at 60 - 65 °C and continue stirring (300 - 500 rpm) for 15 - 20 minutes.

[0168] (5) Cooling and addition of heat-sensitive components

[0169] a. Lower the temperature to 50 - 55 °C through the jacket circulating water, turn off the circulation, and let it stand for 5 minutes.

[0170] b. Continuously cool down to 45 - 50 °C, add pre-dispersed panthenol, inulin, oat β-glucan, plant extracts (Crataegus monogyna, Panax ginseng, Artemisia annua, Centella asiatica) and phosphatidylcholine into the material, and stir at low speed (200 - 300 rpm) for 10 minutes until evenly dispersed.

[0171] c. Continuously cool down to 45 - 50 °C, add dispersed sodium hyaluronate, soluble collagen, and collagen amino acids into the material, and stir at low speed (200 - 300 rpm) for 10 minutes until evenly dispersed.

[0172] d. Continuously cool down to ≤40 °C, add the fermentation product of Thermus thermophilus, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, ceramides (NS / NG / NP / AP), and collagen into the material, and stir at low speed (200 - 300 rpm) for 5 minutes.

[0173] e. Finally, add 3 - O - ethyl ascorbic acid into the material.

[0174] f. Adjust the pH to 5.6 - 6.5 with acetic acid.

[0175] (6) Vacuum degassing

[0176] Turn on the vacuum degassing system (-0.08 MPa), rotate at 100 - 200 rpm, and degas for 10 - 15 minutes.

[0177] (7) Cooling and filling

[0178] Cool to room temperature, and after passing the inspection, filter and fill with a 200 - mesh filter screen.

[0179] Example 3

[0180] A facial cream, comprising the following components (by weight percentage): butylene glycol 1%, oat (AVENA SATIVA) β-glucan 0.15%, 1,2-hexanediol 1.6%, caprylyl glycol 0.03%, glycerol polyether-26 6%, behenyl alcohol 2%, phytosterols 2%, cetyl alcohol 1%, stearyl alcohol 1%, hydrogenated lecithin 0.05%, caprylic / capric triglyceride 4%, glycerol 6.5%, acetic acid 0.001%, collagen 1%, betaine 5%, polydimethylsiloxane 5%, palmitoyl tripeptide-5 0.03%, carbomer 0.05%, sodium lactate 0.05%, polysorbate-20 0.015%, palmitoyl tripeptide-1 0.001%, palmitoyl tetrapeptide-7 0.001%, squalane 3%, dipropylene glycol 1.5%, single-fruit hawthorn (CRATAEGUS MONOGYNA) fruit extract 0.2%, ginseng (PANAX GINSENG) root extract 0.1%, artemisia annua (ARTEMISIA ANNUA) extract 0.1%, panthenol 2%, acryloyldimethyltaurate / VP copolymer 1.3%, sorbitan isostearate 0.1%, hydroxyacetophenone 1.1%, acryloyldimethylammonium taurate / VP copolymer 1%, 3-O-ethyl ascorbic acid 0.25%, phosphatidylcholine 0.026%, tocopheryl acetate 0.002%, ethoxydiglycol 0.002%, ceramide NS / ceramide NG 0.002%, ceramide NP 0.001%, ceramide AP 0.001%, thermus thermophilus (THERMUS THERMOPHILLUS) fermentation product 0.2%, centella asiatica (CENTELLA ASIATICA) leaf extract 0.15%, collagen amino acids 0.5%, xanthan gum 0.2%, sodium hyaluronate 0.1%, inulin 0.5%, α-glucooligosaccharide 0.007%, soluble collagen 0.15%, and water is added up to 100%.

[0181] The preparation method of the facial cream comprises the following steps:

[0182] (1) Preparation of the aqueous phase

[0183] a. Take a clean container, mix carbomer and xanthan gum with dipropylene glycol evenly, and disperse them with a homogenizer (8000 rpm) for 5 minutes to form a particle-free paste.

[0184] b. Add purified water to the reaction kettle, heat it to 65 - 70 °C, set the stirring speed at 150 - 200 rpm, and stir.

[0185] c. Add 1,2-ethylene glycol, glycerol polyether-26, polysorbate-20, and ethoxydiglycol to the reaction kettle, and stir for about 5 minutes until completely miscible.

[0186] d. Add glycerin, betaine, and α-glucooligosaccharide into the reaction kettle and stir for about 10 minutes until completely dissolved.

[0187] e. Finally, add sodium lactate and stir for about 3 minutes.

[0188] f. Visually inspect that the solution should be transparent and free of impurities.

[0189] g. Slowly add the pre-dispersed carbomer / xanthan gum paste through a 100-mesh sieve into the reaction kettle, while increasing the rotation speed to 300 - 400 rpm and continuously stirring for 10 minutes.

[0190] h. Add the copolymer of hydroxyethyl acrylate / sodium acryloyldimethyltaurate and the copolymer of ammonium acryloyldimethyltaurate / VP into the reaction kettle, stir at 150 - 200 rpm, and continuously stir for 10 minutes.

[0191] i. Keep the temperature at 65 - 70 °C for standby.

[0192] (2) Preparation of oil phase

[0193] a. Add behenyl alcohol into the oil-phase reaction kettle, start stirring (80 - 120 rpm), and heat to 75 - 80 °C.

[0194] b. After behenyl alcohol is completely melted, add stearyl alcohol, sorbitan isostearate, and tocopheryl acetate, and continue stirring for 5 - 10 minutes until completely dissolved.

[0195] c. Cool down to 70 - 75 °C, add cetyl alcohol and phytosterols, and continuously stir until completely dissolved.

[0196] d. Cool down to 65 - 70 °C, add triglyceride caprylate / caprate and polydimethylsiloxane, increase the stirring speed to 150 - 200 rpm, and stir for 10 - 15 minutes to ensure that all components of the oil phase are fully miscible (which can be judged by observing whether the liquid surface is stratified).

[0197] e. Cool down to 60 - 65 °C, add p-hydroxyacetophenone, and stir (150 - 200 rpm) until completely dissolved.

[0198] f. Add caprylyl glycol, stir for 5 minutes, and then add hydrogenated lecithin, and stir (150 - 200 rpm) until completely dissolved.

[0199] g. Dip a glass rod into the oil phase, and after cooling, observe that there is no obvious solid particle residue, which is regarded as completely melted.

[0200] h. Filter the oil phase through a 100-mesh sieve.

[0201] i. Keep the temperature of the filtered oil phase at 60 - 65 °C, maintain stirring at 50 rpm, and set aside for use.

[0202] (3) Pre-dispersion of thermosensitive components

[0203] a. Pre-disperse collagen with butanediol at a temperature ≤ 30°C.

[0204] b. Pre-dissolve palmitoyl tripeptide-5, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-7 with dipropylene glycol at a temperature of 2 - 10°C.

[0205] c. Pre-dissolve ceramide (NS / NG / NP / AP) with squalane at a temperature ≤ 30°C.

[0206] d. Pre-dissolve panthenol, inulin, oat β-glucan, plant extracts (monocarp hawthorn, ginseng, artemisia annua, asiatic pennywort), etc. with purified water at a temperature ≤ 40°C.

[0207] e. Pre-swelling of sodium hyaluronate with purified water at a temperature ≤ 40°C.

[0208] f. Pre-dissolve soluble collagen and collagen amino acids with purified water at a temperature ≤ 30°C.

[0209] g. Pre-dissolve 3 - O - ethyl ascorbic acid with purified water at a temperature ≤ 30°C.

[0210] h. Pre-dissolve the fermentation product of Thermus thermophilus with purified water at a temperature ≤ 30°C.

[0211] (4) Emulsification of the material

[0212] a. Primary emulsification: Slowly pump the oil phase into the water phase while stirring (100 - 200 rpm) to form a primary emulsion.

[0213] b. High-shear homogenization: Turn on the high-shear emulsifier (rotation speed 2000 - 3000 rpm) and homogenize for 10 - 15 minutes to ensure uniform dispersion of oil droplets (monitor the temperature during the process and do not exceed 65°C, turn on the jacket water cooling if necessary).

[0214] c. Heat preservation and ripening: Keep the temperature at 60 - 65°C and continue stirring (300 - 500 rpm) for 15 - 20 minutes.

[0215] (5) Cooling and addition of thermosensitive components

[0216] a. Lower the temperature to 50 - 55°C through the jacket circulating water, turn off the circulation, and let it stand for 5 minutes.

[0217] b. Continue to cool down to 45 - 50 °C, add pre-dispersed panthenol, inulin, oat β-glucan, plant extracts (Crataegus monogyna, Panax ginseng, Artemisia annua, Centella asiatica) and phosphatidylcholine into the base material, and stir at low speed (200 - 300 rpm) for 10 minutes until evenly dispersed.

[0218] c. Continue to cool down to 45 - 50 °C, add dispersed sodium hyaluronate, soluble collagen, collagen amino acids into the base material, and stir at low speed (200 - 300 rpm) for 10 minutes until evenly dispersed.

[0219] d. Continue to cool down to ≤40 °C, add the fermentation product of Thermus thermophilus, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, ceramides (NS / NG / NP / AP), collagen into the base material, and stir at low speed (200 - 300 rpm) for 5 minutes.

[0220] e. Finally, add 3 - O - ethyl ascorbic acid into the base material.

[0221] f. Adjust the pH to 5.6 - 6.5 with acetic acid.

[0222] (6) Vacuum degassing

[0223] Turn on the vacuum degassing system (-0.08 MPa), rotate at 100 - 200 rpm, and degas for 10 - 15 minutes.

[0224] (7) Cooling and filling

[0225] Cool to room temperature, after passing the inspection, filter and fill with a 200 - mesh filter screen.

[0226] Comparative Example 1

[0227] A facial cream, comprising the following components (by weight percentage): butylene glycol 1%, oat (AVENA SATIVA) β-glucan 0.15%, 1,2-hexanediol 1.6%, caprylyl glycol 0.03%, glycerol polyether-26 6%, behenyl alcohol 2%, phytosterols 2%, cetyl alcohol 1%, stearyl alcohol 1%, hydrogenated lecithin 0.05%, caprylic / capric triglyceride 4%, glycerol 6.5%, acetic acid 0.001%, betaine 5%, polydimethylsiloxane 5%, palmitoyl tripeptide-5 0.03%, carbomer 0.05%, sodium lactate 0.05%, polysorbate-20 0.015%, palmitoyl tripeptide-1 0.001%, palmitoyl tetrapeptide-7 0.001%, squalane 3%, dipropylene glycol 1.5%, single-fruit hawthorn (CRATAEGUS MONOGYNA) fruit extract 0.2%, ginseng (PANAX GINSENG) root extract 0.1%, artemisia annua (ARTEMISIA ANNUA) extract 0.1%, panthenol 2%, acryloyldimethyltaurate / VP copolymer 1.3%, sorbitan isostearate 0.1%, p-hydroxyacetophenone 1.1%, acryloyldimethyltaurine ammonium / VP copolymer 1%, 3-O-ethyl ascorbic acid 0.25%, phosphatidylcholine 0.026%, tocopheryl acetate 0.002%, 0.002%, ethoxydiglycol 0.002%, ceramide NS / ceramide NG 0.002%, ceramide NP 0.001%, ceramide AP 0.001%, Thermus thermophilus fermentation product 0.2%, centella asiatica (CENTELLA ASIATICA) leaf extract 0.15%, collagen amino acids 0.5%, xanthan gum 0.2%, sodium hyaluronate 0.1%, inulin 0.5%, α-glucan oligosaccharide 0.007%, soluble collagen 0.15%, and water is added to 100%.

[0228] The preparation method of the facial cream comprises the following steps:

[0229] (1) Preparation of the aqueous phase

[0230] a. Take a clean container, mix carbomer and xanthan gum with dipropylene glycol evenly, and disperse them with a homogenizer (8000 rpm) for 5 minutes to form a particle-free paste.

[0231] b. Add purified water to the reaction kettle, heat it to 65-70 °C, set the stirring speed at 150-200 rpm, and stir.

[0232] c. Add 1,2-ethylene glycol, glycerol polyether-26, polysorbate-20, and ethoxydiglycol to the reaction kettle, and stir for about 5 minutes until completely miscible.

[0233] d. Add glycerol, betaine, and α-glucooligosaccharide into the reaction kettle and stir for about 10 minutes until completely dissolved.

[0234] e. Finally, add sodium lactate and stir for about 3 minutes.

[0235] f. Visually inspect that the solution should be transparent and free of impurities.

[0236] g. Pass the pre-dispersed carbomer / xanthan gum paste through a 100-mesh filter screen and slowly add it into the reaction kettle. At the same time, increase the rotation speed to 300 - 400 rpm and continuously stir for 10 minutes.

[0237] h. Add the copolymer of hydroxyethyl acrylate / sodium acryloyldimethyltaurate and the copolymer of ammonium acryloyldimethyltaurate / VP into the reaction kettle and stir at 150 - 200 rpm for 10 minutes.

[0238] i. Keep the temperature at 65 - 70 °C for standby.

[0239] (2) Preparation of the oil phase

[0240] a. Add behenyl alcohol into the oil-phase reaction kettle, start stirring (80 - 120 rpm), and heat to 75 - 80 °C.

[0241] b. After the behenyl alcohol is completely melted, add stearyl alcohol, sorbitan isostearate, and tocopheryl acetate, and continue to stir for 5 - 10 minutes until completely dissolved.

[0242] c. Cool down to 70 - 75 °C, add cetyl alcohol and phytosterols, and continuously stir until completely dissolved.

[0243] d. Cool down to 65 - 70 °C, add triglyceride caprylic / capric acid and polydimethylsiloxane, increase the stirring speed to 150 - 200 rpm, and stir for 10 - 15 minutes to ensure that all components of the oil phase are fully miscible (which can be judged by observing whether the liquid surface is layered).

[0244] e. Cool down to 60 - 65 °C, add p-hydroxyacetophenone, and stir (150 - 200 rpm) until completely dissolved.

[0245] f. Add caprylyl glycol, stir for 5 minutes, and then add hydrogenated lecithin, and stir to (150 - 200 rpm) until completely dissolved.

[0246] g. Dip a glass rod into the oil phase and observe that there is no obvious solid particle residue after cooling, which is regarded as completely melted.

[0247] h. Filter the oil phase through a 100-mesh filter screen.

[0248] i. Keep the temperature of the filtered oil phase at 60 - 65 °C, maintain stirring at 50 rpm, and set aside for use.

[0249] (3) Pre-dispersion of thermosensitive components

[0250] a. Pre-disperse collagen with butylene glycol at a temperature ≤ 30°C.

[0251] b. Pre-dissolve palmitoyl tripeptide-5, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-7 with dipropylene glycol at a temperature of 2 - 10°C.

[0252] c. Pre-dissolve ceramide (NS / NG / NP / AP) with squalane at a temperature ≤ 30°C.

[0253] d. Pre-dissolve panthenol, inulin, oat β-glucan, plant extracts (monocot hawthorn, ginseng, Artemisia annua, asiatic pennywort), etc. with purified water at a temperature ≤ 40°C.

[0254] e. Pre-swell sodium hyaluronate with purified water at a temperature ≤ 40°C.

[0255] f. Pre-dissolve soluble collagen and collagen amino acids with purified water at a temperature ≤ 30°C.

[0256] g. Pre-dissolve 3 - O - ethyl ascorbic acid with purified water at a temperature ≤ 30°C.

[0257] h. Pre-dissolve the fermentation product of Thermus thermophilus with purified water at a temperature ≤ 30°C.

[0258] (4) Emulsification of the material

[0259] a. Primary emulsification: Slowly pump the oil phase into the water phase while stirring (100 - 200 rpm) to form a primary emulsion.

[0260] b. High-shear homogenization: Turn on the high-shear emulsifier (rotation speed 2000 - 3000 rpm) and homogenize for 10 - 15 minutes to ensure uniform dispersion of oil droplets (monitor the temperature during the process and do not exceed 65°C, turn on the jacket water cooling if necessary).

[0261] c. Heat preservation and ripening: Keep the temperature at 60 - 65°C and continue stirring (300 - 500 rpm) for 15 - 20 minutes.

[0262] (5) Cooling and addition of thermosensitive components

[0263] a. Lower the temperature to 50 - 55°C through the jacket circulating water, turn off the circulation and let it stand for 5 minutes.

[0264] b. Continue to cool down to 45 - 50 °C, add the pre-dispersed panthenol, inulin, oat β-glucan, plant extracts (Crataegus monogyna, Panax ginseng, Artemisia annua, Centella asiatica) and phosphatidylcholine into the material, and stir at low speed (200 - 300 rpm) for 10 minutes until evenly dispersed.

[0265] c. Continue to cool down to 45 - 50 °C, add the dispersed sodium hyaluronate, soluble collagen, and collagen amino acids into the material, and stir at low speed (200 - 300 rpm) for 10 minutes until evenly dispersed.

[0266] d. Continue to cool down to ≤40 °C, add the fermentation product of Thermus thermophilus, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, ceramides (NS / NG / NP / AP) into the material, and stir at low speed (200 - 300 rpm) for 5 minutes.

[0267] e. Finally, add 3-O-ethyl ascorbic acid into the material.

[0268] f. Adjust the pH to 5.6 - 6.5 with acetic acid.

[0269] (6) Vacuum degassing

[0270] Turn on the vacuum degassing system (-0.08 MPa), rotate at 100 - 200 rpm, and degas for 10 - 15 minutes.

[0271] (7) Cooling and filling

[0272] Cool to room temperature, after passing the inspection, filter and fill with a 200-mesh filter screen.

[0273] Comparative Example 2

[0274] A facial cream, comprising the following components (by weight percentage): butanediol 1%, oat (AVENA SATIVA) β-glucan 0.15%, 1,2-hexanediol 1.6%, caprylyl glycol 0.03%, glycerol polyether-26 6%, behenyl alcohol 2%, phytosterols 2%, cetyl alcohol 1%, stearyl alcohol 1%, hydrogenated lecithin 0.05%, caprylic / capric triglyceride 4%, glycerol 6.5%, acetic acid 0.001%, collagen 1%, betaine 5%, dimethicone 5%, palmitoyl tripeptide-5 0.03%, carbomer 0.05%, sodium lactate 0.05%, polysorbate-20 0.015%, palmitoyl tripeptide-1 0.001%, palmitoyl tetrapeptide-7 0.001%, squalane 3%, dipropylene glycol 1.5%, single-fruit hawthorn (CRATAEGUS MONOGYNA) fruit extract 0.2%, ginseng (PANAX GINSENG) root extract 0.1%, artemisia annua (ARTEMISIA ANNUA) extract 0.1%, panthenol 2%, acryloyldimethyltaurate / VP copolymer 1.3%, sorbitan isostearate 0.1%, p-hydroxyacetophenone 1.1%, acryloyldimethyltauramide / VP copolymer 1%, 3-O-ethyl ascorbic acid 0.25%, phosphatidylcholine 0.026%, tocopheryl acetate 0.002%, ethoxydiglycol 0.002%, ceramide NS / ceramide NG 0.002%, ceramide NP 0.001%, ceramide AP 0.001%, Thermus thermophilus fermentation product 0.2%, centella asiatica (CENTELLA ASIATICA) leaf extract 0.15%, collagen amino acids 0.5%, xanthan gum 0.2%, sodium hyaluronate 0.1%, inulin 0.5%, α-glucooligosaccharide 0.007%, soluble collagen 0.15%, and water is added up to 100%.

[0275] The preparation method of the facial cream comprises the following steps:

[0276] (1) Preparation of the aqueous phase

[0277] a. Take a clean container, mix carbomer and xanthan gum evenly with dipropylene glycol, and disperse them with a homogenizer (8000 rpm) for 5 minutes to form a particle-free paste.

[0278] b. Add purified water to the reaction kettle, heat it to 75 - 80 °C, set the stirring speed at 200 - 300 rpm, and stir.

[0279] c. Add 1,2-ethylene glycol, polysorbate 20, ethoxydiglycol, glycerin, betaine, α-glucan oligosaccharide, sodium lactate, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and ammonium acryloyldimethyl taurate / VP copolymer into the reactor and stir for about 10 minutes until they are completely dissolved.

[0280] d. Pass the pre-dispersed carbomer / yellow collagen paste through a 100-mesh filter and slowly add it to the reactor while increasing the speed to 300-400 rpm and continuing stirring for 10 minutes.

[0281] e. Maintain the temperature at 75-80℃ for later use.

[0282] (2) Oil phase preparation

[0283] a. Mix caprylic / capric triglyceride and dimethicone and heat to 65-70℃

[0284] b. Sequentially add behenyl alcohol and cetyl alcohol to the oil phase reactor, start stirring (80-120 rpm), and heat to 75-80 ° C.

[0285] c. After it is completely melted, add stearyl alcohol, sorbitan isostearate, tocopheryl acetate, p-hydroxyacetophenone, and caprylyl glycol and continue stirring for 5-10 minutes until it is completely dissolved.

[0286] d. Add hydrogenated lecithin and stir (150-200 rpm) until completely dissolved.

[0287] e. Filter the oil phase with a 100-mesh filter.

[0288] f. Maintain the temperature of the filtered oil phase at 70-75°C for later use.

[0289] (3) Pre-dispersion of heat-sensitive components

[0290] a. Pre-disperse collagen with butylene glycol at a temperature ≤ 30°C.

[0291] b. Pre-dissolve palmitoyl tripeptide-5, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-7 in dipropylene glycol at a temperature of 2-10°C.

[0292] c. Pre-dissolve ceramide (NS / NG / NP / AP) in squalane at a temperature ≤ 30°C.

[0293] d. Pre-dissolve panthenol, inulin, oat β-glucan, plant extracts (crataegus monogyna, ginseng, artemisia annua, Centella asiatica), soluble collagen, collagen amino acids, sodium hyaluronate, etc. in purified water at a temperature of ≤40°C.

[0294] e. Pre-dissolve 3-o-ethyl ascorbic acid in purified water at a temperature ≤ 30°C.

[0295] f. Pre-dissolve the fermentation product of THERMUS THERMOPHILLUS with purified water at a temperature ≤ 30°C.

[0296] (4) Emulsification of the material

[0297] a. Emulsification: Slowly pump the oil phase into the water phase, start the high-shear emulsifier (rotation speed 2000 - 3000 rpm), and homogenize for 10 - 15 minutes to ensure uniform dispersion of oil droplets.

[0298] b. Viscosity adjustment: Add glycerol polyether-26 and phytosterols, and homogenize again (rotation speed 2000 - 3000 rpm) for 5 - 10 minutes, maintain the temperature at 60 - 65°C, and continue stirring (300 - 500 rpm) for 15 - 20 minutes.

[0299] (5) Cooling and addition of heat-sensitive components

[0300] a. Cool the temperature to 50 - 55°C through jacket circulating water, turn off the circulation, and let it stand for 5 minutes.

[0301] b. Continue to cool down to 45 - 50°C, add pre-dispersed panthenol, inulin, oat β-glucan, plant extracts (Crataegus monogyna, Panax ginseng, Artemisia annua, Centella asiatica), sodium hyaluronate, soluble collagen, collagen amino acids, phosphatidylcholine, and collagen to the material, and stir at low speed (200 - 300 rpm) for 10 minutes until evenly dispersed.

[0302] c. Continue to cool down to ≤ 40°C, add the fermentation product of THERMUS THERMOPHILLUS, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, ceramides (NS / NG / NP / AP), and 3-O-ethyl ascorbic acid to the material, and stir at medium speed (300 - 500 rpm) for 10 minutes.

[0303] (6) Vacuum degassing

[0304] Start the vacuum degassing system (-0.08 MPa), rotation speed 100 - 200 rpm, and degas for 10 - 15 minutes.

[0305] (7) Cooling and filling

[0306] Cool to room temperature, after passing the inspection, filter and fill with a 200-mesh filter.

[0307] Performance testing

[0308] Test 1: Zebrafish soothing efficacy test

[0309] Sodium lauryl sulfate (SLS) may cause a stimulatory reaction in the body after acting on it. The stimulant enters the zebrafish body, induces an inflammatory response, and neutrophils undergo an immune response, migrating and aggregating towards the skin epidermis. The change in the number of skin neutrophils before and after treating transgenic neutrophil green fluorescent strain zebrafish (MPX) is used to detect whether the sample has a soothing effect.

[0310] Randomly select zebrafish and place 15 in each well of a 6-well plate.

[0311] Administer SLS in aqueous solution to establish a zebrafish skin inflammation model.

[0312] Administer the sample in aqueous solution, and set up a normal control group and a model control group simultaneously.

[0313] Incubate in the dark at 28 °C for 18 h.

[0314] Randomly select 10 zebrafish from each experimental group and place them under a fluorescence microscope for photographing. Use advanced image processing software to analyze and collect data, analyze the number of skin neutrophils (N) in zebrafish, calculate the soothing effect of the sample according to the formula, and determine whether it has a soothing effect.

[0315]

[0316] Table 1 Test results of the zebrafish model

[0317]

[0318]

[0319] The experimental results show that the number of neutrophils in the sample group is significantly reduced compared with the model control group, revealing that the cream of the present invention has a soothing effect.

[0320] Test 2: Zebrafish anti-wrinkle efficacy experiment

[0321] The growth, repair, nutrition, elasticity, and tension of the skin are all related to collagen. Its loss will reduce the smoothness of the skin and cause wrinkles. In tetrapods, type I collagen is a trimer, mainly composed of two α1 chains and one α2 chain, encoded by the col1a1a and col1a2 genes respectively, and performs collagen-related biological functions in connective tissue and bone. In zebrafish, there are three type I collagen genes, encoding col1a1a, col1a1b, and col1a2 of α1(I), α2(I), and α3(I) chains respectively. Therefore, detecting the relative expression levels of the col1a1a or (and) col1a1b or (and) col1a2 genes can indicate whether the sample has an anti-wrinkle effect.

[0322] Randomly select zebrafish and place 30 in each well of a 6-well plate.

[0323] The sample was administered by dissolving in water. Meanwhile, a normal control group was set up, and the volume per well was 3 mL. There were three biological replicates. Incubation was carried out in the dark at 28 °C for 24 h.

[0324] Total RNA of zebrafish in each experimental group was extracted, cDNA was synthesized, and the gene expressions of β-actin and the target gene were detected by q-PCR. β-actin was used as an internal reference for gene expression, and the relative RNA expression level of the target gene was calculated.

[0325] Relative RNA expression level = 2 ΔΔC(t)

[0326]

[0327] Table 2 Test results of zebrafish model

[0328]

[0329] Test 3: In vivo efficacy test:

[0330] A total of 30 female subjects were recruited for the test, all with East Asian skin. All 30 subjects completed all the tests. Their ages ranged from 33 to 60 years old, with an average age of 47.7 ± 7.3 years. The subjects used the product once in the laboratory. Parameters such as the water content of the stratum corneum, TEWL, skin gloss, skin elasticity R2, skin elasticity R5, skin elasticity F4, facial red area score, wrinkle length, wrinkle number, wrinkle depth, wrinkle volume, skin roughness, and mandibular angle were measured before and after using the product. The test results are as follows:

[0331] Table 3 Test effects of human efficacy examples

[0332]

[0333]

[0334] Table 4 Consumer evaluations

[0335]

[0336]

[0337] Table 5 Evaluation of trial safety

[0338]

[0339] The experimental results show that the cream of the present invention is suitable for sensitive skin, and has the effects of moisturizing, repairing, soothing, nourishing, firming, and anti-wrinkle, and has a brightening effect.

[0340] Test 6 Sensitive skin test

[0341] Thirty eligible subjects with sensitive skin were recruited for this trial. All of them had Chinese skin. The ages of the 30 subjects ranged from 25 to 54 years old, with an average age of 37.8 ± 10.0 years. The subjects used the product once in the morning and once in the evening every day. The degree of recognition of the product's efficacy by the subjects was investigated through a questionnaire at the 1st week and the 4th week of using the product. No adverse reactions were reported during the trial. The survey results of this trial are as follows:

[0342] Table 6 Recognition rates of subjects for skin condition and product at each time point

[0343]

[0344] Table 7 Evaluation of trial safety

[0345]

[0346]

[0347] The experimental results show that: the cream of the present invention is mild and non-irritating, and is suitable for sensitive skin.

[0348] Test 7: Thermal stability test

[0349] The creams obtained in Examples 1 to 3 and Comparative Example 1 were subjected to a thermal stability test to check the product shape.

[0350] They were respectively placed at 0 °C, 25 °C, and 40 °C for 90 days to check the product properties and color. The test results are shown in Table 2.

[0351] Thermal cycling experiment: The creams obtained in Examples 1 to 3 and Comparative Example 1 were placed in a sealed container to ensure it was completely sealed to prevent interference from external humidity or gas. The samples were placed in an incubator set at a temperature of 45 °C for 12 hours. After taking out the samples, they were quickly transferred to a low-temperature box at -5 °C and kept for 12 hours. After completing 1 high-low temperature cycle, it was repeated 6 times; after the cycle, the physical properties such as the appearance, color, odor, viscosity, layering, etc. of the samples were checked.

[0352] Table 8 Test results of Test 7

[0353]

[0354] Collagen is a strong support for the dermis of the skin, playing a role in supporting the skin. The loss of collagen will lead to skin problems such as wrinkles, aging, sagging, and skin spots. Supplementing collagen helps to keep the skin moist, smooth and elastic.

[0355] p-Hydroxyacetophenone can scavenge free radicals, reduce oxidative stress reactions, protect cells from damage. Appropriately adding p-hydroxyacetophenone to skin care products can achieve the effect of whitening the skin, make the skin more elastic, inhibit the growth of certain bacteria and fungi, help maintain skin health, reduce inflammatory responses, relieve symptoms such as skin redness and itching caused by various reasons, protect the skin from ultraviolet damage, improve the skin condition, and make the skin smoother and more delicate.

[0356] Palmitoyl tripeptide-5 can promote the synthesis of collagen and elastin, make the skin look younger and more elastic, and reduce the formation of wrinkles. Clinical trials show that using skin care products containing palmitoyl tripeptide-5 can significantly reduce skin laxity and age lines, improve skin water content, restore skin smoothness and firmness, improve skin color, enhance luster and transparency, inhibit the production of melanin, help fade age spots and even out skin tone.

[0357] Oat (AVENA SATIVA) β-glucan is widely used in skin care due to its excellent anti-aging effect. It can smooth out fine wrinkles, improve skin elasticity, and enhance skin texture. Its unique linear molecular structure endows good transdermal absorption performance, can promote fibroblasts to synthesize collagen, promote wound healing, and repair damaged skin.

[0358] Palmitoyl tripeptide-1 has the function of promoting skin cell metabolism and repair. It belongs to natural macromolecular compounds, can enhance skin elasticity, and can also delay skin aging to a certain extent.

[0359] Palmitoyl tetrapeptide-7 is a polypeptide component that can help promote collagen production and relieve fine lines and wrinkles.

[0360] Monocarp Hawthorn Fruit Extract contains abundant natural vitamin C, helps reduce the generation of free radicals, delays the process of skin aging, makes the skin more firm and smooth, can effectively regulate sebum secretion, reduce skin oiliness, make the skin more refreshing and clean, helps the skin retain moisture, enhance skin moisturizing ability, while inhibiting the production of melanin, reducing age spots and dullness, and making the skin fairer and brighter.

[0361] Phytosterols have functions such as moisturizing, anti-inflammatory, and antioxidant, can improve the skin barrier function, and enhance skin resistance.

[0362] 3-O-Ethylascorbic acid is a derivative of vitamin C, has functions such as whitening and antioxidant, can inhibit the production of melanin, reduce age spots and dullness.

[0363] Ceramide NS, Ceramide NG, Ceramide NP, and Ceramide AP are important components of the skin barrier function. They have functions such as moisturizing, repairing, and antioxidant, can enhance the skin's barrier function, reduce water loss, and promote skin repair and regeneration.

[0364] Collagen amino acids are the basic building blocks of collagen. They have functions such as moisturizing and antioxidant, can promote skin repair and regeneration, and enhance skin elasticity.

[0365] Sodium hyaluronate can absorb 1000 times its own weight of water, achieving the effect of retaining skin moisture and barrier repair when the skin is damaged, increasing skin luster, improving skin nutritional metabolism, making the skin tender, smooth, wrinkle-free, increasing elasticity, and preventing aging.

[0366] Antioxidants such as 3-O-ethyl ascorbic acid and tocopheryl acetate can resist the damage of free radicals and protect the skin from environmental stress. At the same time, collagen, as an important component of the skin, can enhance the elasticity and firmness of the skin, thus delaying skin aging. The combined use of these ingredients can play a synergistic role in jointly resisting skin aging. At the same time, by precisely calculating the content and proportion of each ingredient, it is ensured that no adverse reactions or mutual cancellation occur between them. A reasonable ratio can give full play to the efficacy of each ingredient while avoiding unnecessary waste and side effects.

[0367] Skin conditioners such as oat β-glucan and ginseng root extract can improve the skin condition, provide nutrition and moisture. At the same time, ceramide, as an important part of the skin barrier, can enhance the skin barrier function and reduce water loss. The combined use of these ingredients can accelerate the skin repair process and make the skin healthier and smoother.

[0368] Reasonable ratio: By precisely calculating the content and proportion of each ingredient, it is ensured that no adverse reactions or mutual cancellation occur between them. A reasonable ratio can give full play to the efficacy of each ingredient while avoiding unnecessary waste and side effects.

[0369] The areas for photographing flushing and brightening are the whole face, the area for photographing roughness is the cheek, the area for photographing wrinkles is the outer canthus of the eye, and the area for photographing the mandibular margin angle is the facial mandibular lateral angle.

[0370] The skin of the measurement site of the subjects is exposed, and after being balanced for 20 minutes in an environment with a temperature of 20 - 22°C and a humidity of 40 - 60%, skin measurement is performed using a facial imaging system (Canfield, VISIA, USA).

[0371] Figure 1 For the photo of improved flushing (in the figure, the control example is Control Example 1; the example is Example 1); Figure 2For the photo of brightening improvement, the control ratio is control ratio 1; the example is example 1). Figure 3 For the photo of wrinkle improvement, the control ratio is control ratio 1; the example is example 1). Figure 4 For the photo of roughness improvement, the control ratio is control ratio 1; the example is example 1). Figure 5 For the photo of mandibular angle improvement, the control ratio is control ratio 1; the example is example 1).

[0372] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than limiting it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A collagen composition applicable to sensitive skin and having multiple functions, characterized in that, The components of the composition include: Crataegus monogyna fruit extract, Panax ginseng root extract, Artemisia annua extract, and Centella asiatica extract.

2. The collagen composition with multiple effects applicable to sensitive skin according to claim 1, characterized in that, The composition further includes oat β-glucan.

3. A collagen composition applicable to sensitive skin and having multiple functions according to claim 1, characterized in that, The composition further includes panthenol, sodium lactate, and betaine.

4. A collagen composition applicable to sensitive skin and having multiple effects according to claim 1, characterized in that, The composition further includes a polypeptide composition.

5. A collagen skin care product suitable for sensitive skin with multiple effects, characterized in that, The raw materials for preparing the skin care product include the collagen composition according to any one of claims 1 to 4.

6. The collagen skin care product according to claim 5, wherein The raw materials for preparing the skin care product include: 1% - 5% of butanediol, 0.04% - 0.2% of Avena sativa β - glucan, 0.05% - 2% of 1,2 - hexanediol, 0.005% - 0.03% of caprylyl glycol, 2% - 8% of glycerol polyether - 26, 0.5% - 2% of behenyl alcohol, 0.5% - 3% of phytosterols, 0.4% - 1.5% of cetyl alcohol, 0.5% - 2% of stearyl alcohol, 0.01% - 0.1% of hydrogenated lecithin, 1% - 5% of caprylic / capric triglyceride, 2% - 8% of glycerol, 0.0005% - 0.002% of acetic acid, 0.1% - 1% of collagen, 1% - 5% of betaine, 1% - 5% of dimethicone, 0.005% - 0.3% of palmitoyl tripeptide - 5, 0.01% - 0.05% of carbomer, 0.01% - 0.05% of sodium lactate, 0.005% - 0.02% of polysorbate - 20, 0.0001% - 0.001% of palmitoyl tripeptide - 1, 0.00001% - 0.001% of palmitoyl tetrapeptide - 7, 0.5% - 3% of squalane, 0.5% - 2% of dipropylene glycol, 0.1% - 0.5% of Crataegus monogyna fruit extract, 0.01% - 0.1% of Panax ginseng root extract, 0.01% - 0.1% of Artemisia annua extract, 0.5% - 3% of panthenol, 0.5% - 2% of sodium acryloyldimethyltaurate / VP copolymer, 0.02% - 0.2% of sorbitan isostearate, 0.5% - 2% of p - hydroxyacetophenone, 0.2% - 1% of acryloyldimethyltauramide / VP copolymer, 0.1% - 0.5% of 3 - O - ethyl ascorbic acid, 0.01% - 0.05% of phosphatidylcholine, 0.0005% - 0.002% of tocopheryl acetate, 0.0005% - 0.002% of ethoxydiglycol, 0.0005% - 0.002% of ceramide NS / ceramide NG, 0.0001% - 0.001% of ceramide NP, 0.0001% - 0.001% of ceramide AP, 0.05% - 0.2% of Thermus thermophilus fermentation product, 0.02% - 0.2% of Centella asiatica leaf extract, 0.00001% - 1% of collagen amino acids, 0.01% - 0.5% of xanthan gum, 0.01% - 0.5% of sodium hyaluronate, 0.005% - 0.5% of inulin, 0.0001% - 0.01% of α - glucan oligosaccharide, 0.001% - 0.2% of soluble collagen, and water is added to 100%.

7. The collagen skin care product according to claim 6, wherein, The raw materials for preparing the skin care product include: 1% Butylene Glycol, 0.15% Avena Sativa β-Glucan, 1.6% 1,2-Hexanediol, 0.03% Caprylyl Glycol, 6% Glycereth-26, 2% Behenyl Alcohol, 2% Phytosterols, 1% Cetyl Alcohol, 1% Stearyl Alcohol, 0.05% Hydrogenated Lecithin, 4% Caprylic / Capric Triglyceride, 6.5% Glycerin, 0.001% Acetic Acid, 1% Collagen, 5% Betaine, 5% Dimethicone, 0.03% Palmitoyl Tripeptide-5, 0.05% Carbomer, 0.05% Sodium Lactate, 0.015% Polysorbate-20, 0.001% Palmitoyl Tripeptide-1, 0.001% Palmitoyl Tetrapeptide-7, 3% Squalane, 1.5% Dipropylene Glycol, 0.2% Crataegus Monogyna Fruit Extract, 0.1% Panax Ginseng Root Extract, 0.1% Artemisia Annua Extract, 2% Panthenol, 1.3% Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, 0.1% Sorbitan Isostearate, 1.1% p-Hydroxyacetophenone, 1% Ammonium Acryloyldimethyltaurate / VP Copolymer, 0.25% 3-O-Ethyl Ascorbic Acid, 0.026% Phosphatidylcholine, 0.002% Tocopheryl Acetate, 0.002% Ethoxydiglycol, 0.002% Ceramide NS / Ceramide NG, 0.001% Ceramide NP, 0.001% Ceramide AP, 0.2% Thermus Thermophilus Ferment, 0.15% Centella Asiatica Leaf Extract, 0.5% Collagen Amino Acids, 0.2% Xanthan Gum, 0.1% Sodium Hyaluronate, 0.5% Inulin, 0.007% α-Glucan Oligosaccharide, 0.15% Soluble Collagen, Water added to 100%.

8. A method for preparing the skin care product according to any one of claims 5 to 7, characterized in that, The steps are as follows: (1) Preparation of the aqueous phase a. Take a clean container, mix Carbomer and Xanthan Gum with Dipropylene Glycol evenly, disperse with a homogenizer for 5 minutes to form a particle-free paste; b. Add purified water to the reaction kettle, heat to 65 - 70 °C, set the stirring speed at 150 - 200 rpm, and stir; c. Add 1,2-Ethylene Glycol, Glycereth-26, Polysorbate-20, and Ethoxydiglycol to the reaction kettle, and stir for about 5 minutes until completely miscible; d. Add Glycerin, Betaine, and α-Glucan Oligosaccharide to the reaction kettle, and stir for about 10 minutes until completely dissolved; e. Finally, add Sodium Lactate and stir for about 3 minutes; f. Visually inspect that the solution should be transparent and free of impurities; g. Slowly add the pre-dispersed Carbomer / Xanthan Gum paste through a 100-mesh filter into the reaction kettle, while increasing the rotation speed to 300 - 400 rpm, and continuously stir for 10 minutes; h. Add hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer and ammonium acryloyldimethyltaurate / VP copolymer into the reaction kettle, stir at 150 - 200 rpm for 10 minutes continuously; i. Keep the temperature at 65 - 70 °C for standby; (2) Preparation of oil phase a. Add behenyl alcohol into the oil phase reaction kettle, start stirring, and heat to 75 - 80 °C; b. After the behenyl alcohol is completely melted, add stearyl alcohol, sorbitan isostearate, and tocopheryl acetate, and continue stirring for 5 - 10 minutes until completely dissolved; c. Cool down to 70 - 75 °C, add cetyl alcohol and phytosterols, and continue stirring until completely dissolved; d. Cool down to 65 - 70 °C, add triglyceride caprylate / caprate and polydimethylsiloxane, increase the stirring speed to 150 - 200 rpm, and stir for 10 - 15 minutes to ensure that all components of the oil phase are fully miscible; e. Cool down to 60 - 65 °C, add p - hydroxyacetophenone, and stir until completely dissolved; f. Add caprylyl glycol, stir for 5 minutes, and then add hydrogenated lecithin, and stir until completely dissolved; g. Dip a glass rod into the oil phase, and if there is no obvious solid particle residue after cooling, it is regarded as completely melted; h. Filter the oil phase through a 100 - mesh filter screen; i. Keep the temperature of the filtered oil phase at 60 - 65 °C, maintain stirring at 50 rpm, and set aside for use; (3) Pre - dispersion of heat - sensitive components a. Pre - disperse collagen with butylene glycol at a temperature ≤ 30 °C; b. Pre - dissolve palmitoyl tripeptide - 5, palmitoyl tripeptide - 1, and palmitoyl tetrapeptide - 7 with dipropylene glycol at a temperature of 2 - 10 °C; c. Pre - dissolve ceramide with squalane at a temperature ≤ 30 °C; d. Pre - dissolve panthenol, inulin, oat β - glucan, and plant extracts with purified water at a temperature ≤ 40 °C; e. Pre - swell sodium hyaluronate with purified water at a temperature ≤ 40 °C; f. Pre - dissolve soluble collagen and collagen amino acids with purified water at a temperature ≤ 30 °C; g. Pre - dissolve 3 - O - ethyl ascorbic acid with purified water at a temperature ≤ 30 °C; h. Pre - dissolve Thermus thermophilus fermentation product with purified water at a temperature ≤ 30 °C; (4) Emulsification of the formulation a. Primary emulsification: Slowly pump the oil phase into the water phase, stir while adding to form a primary emulsion; b. High - shear homogenization: Turn on the high - shear emulsifier, homogenize for 10 - 15 min to ensure uniform dispersion of oil droplets; c. Heat preservation and ripening: Keep the temperature at 60 - 65 °C and continue stirring for 15 - 20 minutes; (5) Cooling and addition of heat - sensitive components a. Cool the temperature to 50 - 55 °C through jacket circulating water, turn off the circulation, and let it stand for 5 minutes; b. Continue to cool down to 45 - 50 °C, add the pre - dispersed panthenol, inulin, oat β - glucan, plant extracts and phosphatidylcholine into the formulation, and stir at low speed for 10 minutes until evenly dispersed; c. Continue to cool down to 45 - 50 °C, add the dispersed sodium hyaluronate, soluble collagen, and collagen amino acids into the formulation, and stir at low speed for 10 minutes until evenly dispersed; d. Continuously cool down to ≤40°C, add Thermus thermophilus fermentation product, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, ceramide, and collagen into the material, and stir at low speed for 5 minutes; e. Finally, add 3-O-ethyl ascorbic acid into the material; f. Adjust the pH to 5.6 - 6.5 with acetic acid; (6) Vacuum degassing Turn on the vacuum degassing system, with a rotation speed of 100 - 200 rpm, and degas for 10 - 15 minutes; (7) Cooling and filling Cool down to room temperature, after passing the inspection, filter and fill with a 200-mesh filter screen.

9. The skin care product according to any one of claims 4 to 6, characterized in that The skin care product is a cream or lotion.

10. The collagen composition according to any one of claims 1 to 3, characterized in that, It is applied to the daily chemical field.

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