Phenolic diastereoisomer as well as preparation method and application thereof

By isolating and resolving the phenolic compounds in fresh bamboo leucite, the phenolic diastereoisomers (+)-fresh bamboo leucite phenol D and (-)-fresh bamboo leucite phenol D are obtained, and the problem of indistinguishable diastereoisomers of phenolic compounds is solved, and the significant effect on neuronal cell protection is achieved, providing a new drug basis for the treatment of neurodegenerative diseases.

CN120398652AActive Publication Date: 2025-08-01JIANGXI INST OF DRUG INSPECTION & TESTING
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Patent Information

Application Number
CN202510897467.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-01
Publication Date
2025-08-01
Estimated Expiration
2045-07-01

AI Technical Summary

Technical Problem

The prior art cannot effectively distinguish the diastereoisomers of phenolic compounds in fresh bamboo leucite, resulting in insufficient accuracy in drug efficacy and safety analysis, affecting its application in the treatment of respiratory diseases.

Method used

High performance liquid chromatography is prepared by a series of steps including dry distillation, under-pressure concentration, extraction, macroporous resin column separation, silica gel column chromatography, gel separation and reverse phase preparation, and finally the phenolic diastereomers are resolved, and (+)-fresh bamboo leach phenol D and (-)-fresh bamboo leach phenol D are obtained.

Benefits of technology

The phenolic diastereomers were successfully obtained. (+)-fresh bamboo leptophan D showed significant protective effects on nerve cell damage caused by glutamate, providing a new basis for pharmacological research on fresh bamboo leptophan and having the potential to prevent or treat neurodegenerative diseases.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine biology, and particularly relates to a phenolic diastereoisomer and a preparation method and application thereof.The phenolic diastereoisomer has the chemical structural formula shown in the formula I and the formula II, the formula I is dextroisomer and is named as (+)-fresh bamboo juice phenol D, and the formula II is levoisomer and is named as (-)-fresh bamboo juice phenol D. A pair of phenolic diastereoisomer compounds (+)-fresh bamboo juice phenol D and (-)-fresh bamboo juice phenol D are successfully obtained from fresh bamboo juice, and an anti-neurotoxicity activity test shows that (+)-fresh bamboo juice phenol D has a remarkable protection effect on PC12 cell injury caused by glutamic acid and can be used for preparing medicines for preventing or treating neurodegenerative diseases; wide application prospects are realized.
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