Scalp soothing and dandruff removing composition and application thereof

Abstract

The invention relates to a scalp soothing and anti-dandruff composition and application thereof. The scalp soothing and anti-dandruff composition is prepared from clomidazole, paeonol, decyl oxazolidinone and a plant extract. Wherein the clomiprazole, the paeonol and the decyl oxazolidinone have a remarkable synergistic effect in the aspects of bacteriostasis, dandruff removal, itching relieving and soothing, and the soothing and dandruff removal effects of the composition can be greatly improved by combined use of the clomiprazole, the paeonol and the decyl oxazolidinone. Meanwhile, the plant extract is added into the composition, so that the ecological balance of scalp can be further adjusted, and the relieving and dandruff removing effects can be promoted to be exerted by the clomidazole, the paeonol and the decyl oxazolidinone.

Description

Technical Field

[0001] The invention belongs to the field of daily cosmetics, and particularly relates to a scalp-soothing and anti-dandruff composition and application thereof. Background Art

[0002] With the accelerating pace of life, modern people's unhealthy dietary habits, such as greasy and spicy foods, and unhealthy lifestyles like staying up late, can easily stimulate the secretion of oil in the scalp's sebaceous glands. As more and more consumers experience problems such as excessive scalp oil secretion, dandruff, and scalp sensitivity, their demand for effective shampoo and conditioner products is gradually increasing. The imbalance of the scalp's ecological environment and the increase in dandruff have led to a more urgent demand for shampoo and conditioner products with soothing and anti-dandruff properties.

[0003] Currently, most of the anti-dandruff shampoos on the market temporarily eliminate dandruff from the surface by degreasing. Once they are discontinued, serious dandruff problems will recur. In addition, long-term use of degreasing to remove dandruff will lead to scalp sensitivity, damage the skin barrier, and cause an imbalance in oil secretion. In severe cases, it will cause other scalp problems, and does not fundamentally solve the scalp problems that cause itching and dandruff.

[0004] CN119868178A discloses an anti-mite and anti-dandruff shampoo and its preparation method. The preparation method comprises: surface-modifying a eugenol / functionalized mesoporous nano-silica composite material with antibacterial, anti-mite, and anti-dandruff properties with liposomes, further surface-modifying cholesterol-modified hyaluronic acid via a post-insertion method, and mixing the resulting antibacterial and anti-mite agent with an anti-dandruff agent and water to obtain an anti-mite and anti-dandruff composition; and then compounding and mixing a cationic polymer, a surfactant, a thickener, a fragrance, the anti-mite and anti-dandruff composition, and water to obtain a shampoo with excellent antibacterial and anti-mite effects and good anti-dandruff effects. This shampoo is complex in raw materials and uses a large amount of surfactant, which cannot guarantee long-term relief for the scalp.

[0005] Therefore, how to develop a composition with soothing and anti-dandruff effects to regulate the scalp condition has become one of the technical problems that need to be solved urgently. Summary of the Invention

[0006] In view of the shortcomings of the prior art, the present invention aims to provide a scalp soothing and anti-dandruff composition and its application. The composition can regulate the ecological balance of the scalp and has significant soothing and anti-dandruff effects.

[0007] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides a scalp-soothing and anti-dandruff composition, which comprises climbazole, paeonol, decyl oxazolidinone and a plant extract.

[0009] Climbazole has unique antifungal ability and has obvious inhibitory effects on Bacillus ovale or Pityriasis ovale, as well as Candida albicans and Trichophyton, which cause dandruff; Paeonol is an active ingredient extracted and separated from the root bark of peony, which has multiple effects such as sedation, antibacterial and anti-inflammatory. At the same time, adding it to shampoo can regulate hair growth and play a softening and anti-dandruff effect; Decyloxazolidinone is a mild, effective and economical antibacterial agent with a low risk factor, and is safe and mild.

[0010] The present invention creatively discovered that climbazole, paeonol and decyl oxazolidinone have significant synergistic effects in antibacterial, antidandruff, antipruritic and soothing effects, and their combined use can greatly improve the soothing and antidandruff effects of the composition.

[0011] In addition, adding plant extracts to the composition can further regulate the ecological balance of the scalp and promote the soothing and anti-dandruff effects of climbazole, paeonol and decyl oxazolidinone.

[0012] Preferably, the scalp soothing and anti-dandruff composition comprises, by weight, 1-10 parts of climbazole, 0.5-5 parts of paeonol, 0.5-5 parts of decyl oxazolidinone and 0.1-1 part of a plant extract.

[0013] Among them, the specific point values in 1-10 can be selected from 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, etc., the specific point values in 0.5-5 parts can be selected from 0.5 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc., and the specific point values in 0.1-1 parts can be selected from 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, etc.

[0014] Preferably, the plant extract comprises grapefruit peel extract and / or white willow bark extract.

[0015] Preferably, the plant extracts include grapefruit peel extract and white willow bark extract.

[0016] Grapefruit peel extract is derived from the dried outer peel of grapefruit and contains a variety of active ingredients, including naringin, hesperidin, limonene, caffeic acid, and vitamin C. White willow bark extract is derived from the bark of the white willow tree and is rich in salicin, tannins, quercetin, and other ingredients. It has soothing, anti-inflammatory, analgesic, antibacterial, and antioxidant effects.

[0017] The present invention creatively discovered that grapefruit peel extract and white willow bark extract can well regulate the ecological balance of the scalp, and have a significant synergistic effect in assisting climbazole, paeonol and decyl oxazolidinone in exerting soothing and anti-dandruff effects.

[0018] Preferably, the mass ratio of the grapefruit peel extract to the white willow bark extract is 1:(1-10), for example, it can be 1:1, 1:3, 1:5, 1:7, 1:10, etc.

[0019] Based on the role of grapefruit peel extract and white willow bark extract in regulating the ecological balance of the scalp, when the two are compounded in the above ratio, they can better exert a synergistic effect, thereby improving the overall soothing and anti-dandruff effect of the composition.

[0020] Preferably, the grapefruit peel extract is prepared by a preparation method comprising the following steps:

[0021] The grapefruit peel raw material is mixed with water and subjected to ultrahigh pressure treatment to obtain a mixed liquid, and the mixed liquid is then subjected to vacuum decompression reflux extraction treatment to obtain the grapefruit peel extract.

[0022] The invention extracts the effective components in the grapefruit peel by vacuum decompression reflux extraction, and simultaneously performs ultrahigh pressure pretreatment on the grapefruit peel, thereby better promoting the release of the effective components.

[0023] Preferably, the material-liquid ratio of the grapefruit peel raw material to water is 1:(5-20) g / mL, for example, 1:5 g / mL, 1:10 g / mL, 1:15 g / mL, or 1:20 g / mL.

[0024] Preferably, the ultrahigh pressure treatment is performed at a pressure of 200-400 MPa and for a time of 5-10 min.

[0025] Among them, the specific point values in 200-400MPa can be selected from 200MPa, 220MPa, 240MPa, 260MPa, 280MPa, 300MPa, 320MPa, 340MPa, 360MPa, 380MPa, 400MPa, etc., and the specific point values in 5-10min can be selected from 5min, 6min, 7min, 8min, 9min, 10min, etc.

[0026] In the process of ultrahigh pressure pretreatment of grapefruit peel, the pressure is controlled at 200-400 MPa, which can better promote the release of effective ingredients and is more conducive to the prepared grapefruit peel extract to exert auxiliary anti-dandruff effect.

[0027] Preferably, the vacuum degree of the vacuum decompression reflux extraction treatment is 0.03-0.07 MPa, the temperature is 40-60° C., and the time is 0.5-2 h.

[0028] Among them, the specific point values in 0.03-0.07MPa can be selected from 0.03MPa, 0.04MPa, 0.05MPa, 0.06MPa, 0.07MPa, etc., the specific point values in 40-60℃ can be selected from 40℃, 45℃, 50℃, 55℃, 60℃, etc., and the specific point values in 0.5-2h can be selected from 0.5h, 1h, 1.5h, 2h, etc.

[0029] Preferably, the white willow bark extract is prepared by a preparation method comprising the following steps:

[0030] The white willow bark raw material is mixed with a solution containing a low eutectic solvent and subjected to hot extraction to obtain a white willow bark extract.

[0031] In the present invention, the white willow bark is hot-extracted using a solution containing a deep eutectic solvent, which can better increase the content of the active ingredient.

[0032] Preferably, the raw materials for preparing the solution containing a deep eutectic solvent include a deep eutectic solvent and water.

[0033] Preferably, the deep eutectic solvent is obtained by reacting oxalic acid and L-carnitine.

[0034] The present invention creatively discovered that using oxalic acid as a hydrogen bond donor and L-carnitine as a hydrogen bond acceptor to form a low eutectic solvent can better achieve the extraction effect of the effective components in the white willow bark extract.

[0035] Preferably, the molar ratio of oxalic acid to L-carnitine is (3-5):1, for example, 3:1, 3.5:1, 4:1, 4.5:1, or 5:1.

[0036] Preferably, the solution containing a deep eutectic solvent is prepared by a preparation method comprising the following steps:

[0037] Oxalic acid and L-carnitine are mixed, reacted at 70-90° C. for 1-5 hours, cooled to 20-40° C., and then mixed with water to obtain a solution containing a deep eutectic solvent.

[0038] Among them, the specific point values in 70-90℃ can be selected from 70℃, 75℃, 80℃, 85℃, 90℃, etc., the specific point values in 1-5h can be selected from 1h, 2h, 5h, 4h, 5h, etc., and the specific point values in 20-40℃ can be selected from 20℃, 25℃, 30℃, 35℃, 40℃, etc.

[0039] Preferably, the mass ratio of the deep eutectic solvent to water is (1-5):1, for example, it can be 1:1, 2:1, 3:1, 4:1, 5:1, etc.

[0040] Preferably, the material-liquid ratio of the white willow bark raw material to the solution containing the deep eutectic solvent is 1:(5-10) g / mL, for example, it can be 1:5 g / mL, 1:6 g / mL, 1:7 g / mL, 1:8 g / mL, 1:9 g / mL, 1:10 g / mL, etc.

[0041] Preferably, the temperature of the hot extraction is 50-65° C., and the time of the hot extraction is 0.5-2 h.

[0042] Among them, the specific point values in 50-65℃ can be selected from 50℃, 55℃, 60℃, 65℃, etc., and the specific point values in 0.5-2h can be selected from 0.5h, 1h, 1.5h, 2h, etc.

[0043] In a second aspect, the present invention provides a soothing and anti-dandruff shampoo, comprising the scalp soothing and anti-dandruff composition according to the first aspect, a surfactant, a hair conditioner, and a solvent.

[0044] Preferably, the surfactant includes any one of sodium olefin sulfonate, sodium lauroyl sarcosinate, lauryl betaine or sodium lauryl glucose carboxylate, or a combination of at least two thereof.

[0045] Preferably, the hair conditioning agent comprises any one of sodium polyaspartate, butylene glycol, panthenol or bisabolol, or a combination of at least two thereof.

[0046] Preferably, the solvent comprises water.

[0047] Preferably, the soothing and anti-dandruff shampoo comprises, by mass, 1-5 parts of the scalp soothing and anti-dandruff composition of the first aspect, 10-20 parts of a surfactant, 1-10 parts of a hair conditioner, and 50-85 parts of a solvent.

[0048] Among them, the specific point values in 1-5 portions can be selected from 1 portion, 2 portions, 3 portions, 4 portions, 5 portions, etc., the specific point values in 10-20 portions can be selected from 10 portions, 12 portions, 14 portions, 16 portions, 18 portions, 20 portions, etc., the specific point values in 1-10 portions can be selected from 1 portion, 2 portions, 4 portions, 6 portions, 8 portions, 10 portions, etc., and the specific point values in 50-85 portions can be selected from 50 portions, 55 portions, 60 portions, 65 portions, 70 portions, 75 portions, 80 portions, 85 portions, etc.

[0049] In a third aspect, the present invention provides a method for preparing the soothing anti-dandruff shampoo according to the second aspect, the preparation method comprising:

[0050] (1) The solvent and the surfactant are mixed and homogeneously prepared to obtain a mixed solution A; the scalp soothing and anti-dandruff composition described in the first aspect and the hair conditioner are mixed and stirred to obtain a mixed solution B.

[0051] (2) Mixing the mixed solution A and the mixed solution B and stirring them to obtain the soothing anti-dandruff shampoo.

[0052] Preferably, the temperature of the mixing and homogenization before obtaining the mixed solution A in step (1) is 75-85° C., the mixing and homogenization time is 5-20 min, and the mixing and homogenization speed is 10-40 rpm.

[0053] Preferably, the temperature of the mixing and stirring before obtaining the mixed solution B in step (1) is 40-50° C., the time of the mixing and stirring is 5-20 min, and the speed of the mixing and stirring is 10-40 rpm.

[0054] Preferably, the mixing temperature in step (2) is 40-50° C., the mixing time is 5-20 min, and the mixing speed is 10-40 rpm.

[0055] Among them, the specific point values in 75-85℃ can be selected from 75℃, 77℃, 79℃, 81℃, 83℃, 85℃, etc., the specific point values in 40-50℃ can be selected from 40℃, 42℃, 44℃, 46℃, 48℃, 50℃, etc., the specific point values in 5-20min can be selected from 5min, 10min, 15min, 20min, etc., and the specific point values in 10-40rpm can be selected from 10rpm, 20rpm, 30rpm, 40rpm, etc.

[0056] The numerical range described in the present invention includes not only the point values listed above, but also any point values between the above numerical ranges that are not listed. Due to space limitations and for the sake of simplicity, the present invention no longer exhaustively lists the specific point values included in the range.

[0057] Compared with the prior art, the present invention has the following beneficial effects:

[0058] The present invention provides a scalp-soothing and anti-dandruff composition, wherein climbazole, paeonol, and decyloxazolidinone exhibit significant synergistic effects in terms of antibacterial, antidandruff, antipruritic, and soothing properties. Their combined use significantly enhances the composition's soothing and anti-dandruff effects. Furthermore, the addition of plant extracts to the composition can further regulate the ecological balance of the scalp and promote the soothing and anti-dandruff effects of climbazole, paeonol, and decyloxazolidinone.

[0059] Furthermore, among the plant extracts, grapefruit peel extract and white willow bark extract can be used synergistically to regulate the ecological balance of the scalp, assisting climbazole, paeonol and decyl oxazolidinone in exerting soothing and anti-dandruff effects.

[0060] Furthermore, the effective ingredients in the grapefruit peel are extracted by vacuum decompression reflux extraction, and the grapefruit peel is subjected to ultrahigh pressure pretreatment to better promote the release of the effective ingredients. In addition, controlling the pressure of the ultrahigh pressure treatment at 200-400 MPa can better promote the release of the effective ingredients and is more conducive to the prepared grapefruit peel extract to exert its auxiliary anti-dandruff effect.

[0061] Furthermore, during the preparation of the willow bark extract, heat extraction of the willow bark using a solution containing a deep eutectic solvent can further increase the content of the active ingredients. Furthermore, using L-carnitine as a hydrogen bond acceptor and oxalic acid as a hydrogen bond donor to form a deep eutectic solvent can further enhance the extraction of the active ingredients in the willow bark extract. DETAILED DESCRIPTION

[0062] In order to further illustrate the technical means and effects adopted by the present invention, the technical solutions of the present invention are further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0063] The sources of the components / raw materials in the following embodiments are shown in Table 1.

[0064] Table 1

[0065]

[0066] Preparation Example 1-1

[0067] This preparation example provides a grapefruit peel extract, which is prepared by the following method:

[0068] (1) Grapefruit peel was crushed to obtain grapefruit peel powder, and the grapefruit peel powder was mixed with water at a material-liquid ratio of 1:10 g / mL and subjected to ultrahigh pressure treatment (ultrahigh pressure treatment pressure was 300 MPa and time was 8 min).

[0069] (2) The treated mixed solution was subjected to vacuum decompression reflux extraction (vacuum degree of 0.05 MPa, heating temperature of 50° C., extraction time of 1 h) to obtain an extract, which was concentrated and freeze-dried to obtain a grapefruit peel extract.

[0070] Preparation Example 1-2

[0071] This preparation example provides a grapefruit peel extract, which is prepared by the following method:

[0072] (1) Grapefruit peel was crushed to obtain grapefruit peel powder, and the grapefruit peel powder was mixed with water at a material-liquid ratio of 1:5 g / mL and subjected to ultrahigh pressure treatment (ultrahigh pressure treatment pressure was 200 MPa and time was 10 min).

[0073] (2) The treated mixed solution was subjected to vacuum decompression reflux extraction (vacuum degree of 0.03 MPa, heating temperature of 40° C., extraction time of 2 h) to obtain an extract, which was concentrated and freeze-dried to obtain a grapefruit peel extract.

[0074] Preparation Examples 1-3

[0075] This preparation example provides a grapefruit peel extract, which is prepared by the following method:

[0076] (1) Grapefruit peel was crushed to obtain grapefruit peel powder, and the grapefruit peel powder was mixed with water at a material-liquid ratio of 1:20 g / mL and subjected to ultrahigh pressure treatment (ultrahigh pressure treatment pressure was 400 MPa and time was 5 min).

[0077] (2) The treated mixed solution was subjected to vacuum decompression reflux extraction (vacuum degree of 0.07 MPa, heating temperature of 60° C., extraction time of 0.5 h) to obtain an extract, which was concentrated and freeze-dried to obtain a grapefruit peel extract.

[0078] Preparation Examples 1-4

[0079] This preparation example provides a grapefruit peel extract, which differs from Preparation Example 1-1 only in that the pressure of the ultrahigh pressure treatment in step (1) is adjusted to 100 MPa, and the remaining steps are consistent with Preparation Example 1-1.

[0080] Preparation Examples 1-5

[0081] This preparation example provides a grapefruit peel extract, which differs from Preparation Example 1-1 only in that the pressure of the ultrahigh pressure treatment in step (1) is adjusted to 500 MPa, and the remaining steps are consistent with Preparation Example 1-1.

[0082] Preparation Example 2-1

[0083] This preparation example provides a willow bark extract, which is prepared by the following method:

[0084] (1) Preparing a solution containing a deep eutectic solvent: oxalic acid and L-carnitine were mixed in a molar ratio of 4:1, reacted at 80°C for 2 hours, cooled to 30°C, and then mixed with water in a mass ratio of 3:1 to obtain a solution containing a deep eutectic solvent.

[0085] (2) The bark of the white willow was crushed to obtain white willow bark powder, which was mixed with a solution containing a low eutectic solvent at a solid-liquid ratio of 1:7 g / mL, and hot extraction was performed (extraction at 60°C for 1 hour) to obtain an extract. The extract was concentrated and freeze-dried to obtain a white willow bark extract.

[0086] Preparation Example 2-2

[0087] This preparation example provides a willow bark extract, which is prepared by the following method:

[0088] (1) Preparing a solution containing a deep eutectic solvent: oxalic acid and L-carnitine were mixed in a molar ratio of 3:1, reacted at 70°C for 5 h, cooled to 20°C, and then mixed with water in a mass ratio of 5:1 to obtain a solution containing a deep eutectic solvent.

[0089] (2) The bark of the white willow was crushed to obtain white willow bark powder, which was mixed with a solution containing a low eutectic solvent at a solid-liquid ratio of 1:5 g / mL, and hot extraction was performed (extraction at 50°C for 2 h) to obtain an extract. The extract was concentrated and freeze-dried to obtain a white willow bark extract.

[0090] Preparation Example 2-3

[0091] This preparation example provides a willow bark extract, which is prepared by the following method:

[0092] (1) Preparing a solution containing a deep eutectic solvent: oxalic acid and L-carnitine were mixed in a molar ratio of 5:1, reacted at 90°C for 1 hour, cooled to 40°C, and then mixed with water in a mass ratio of 2:1 to obtain a solution containing a deep eutectic solvent.

[0093] (2) The bark of the white willow was crushed to obtain white willow bark powder, which was mixed with a solution containing a low eutectic solvent at a solid-liquid ratio of 1:10 g / mL, and hot extraction was performed (extraction at 65°C for 0.5 h) to obtain an extract. The extract was concentrated and freeze-dried to obtain a white willow bark extract.

[0094] Preparation Example 2-4

[0095] This preparation example provides a willow bark extract, which differs from Preparation Example 2-1 only in that oxalic acid is replaced with an equimolar amount of propionic acid in step (1), and the remaining steps are consistent with Preparation Example 2-1.

[0096] Preparation Example 2-5

[0097] This preparation example provides a willow bark extract, which differs from Preparation Example 2-1 only in that L-carnitine is replaced with an equimolar amount of choline chloride in step (1), and the remaining steps are consistent with Preparation Example 2-1.

[0098] Preparation Example 2-6

[0099] This preparation example provides a willow bark extract, which differs from Preparation Example 2-1 only in that step (1) of preparing a solution containing a low eutectic solvent is not performed, and step (2) is adjusted to mixing willow bark powder and water at a material-liquid ratio of 1:7 g / mL. The remaining steps are consistent with Preparation Example 2-1.

[0100] Example 1

[0101] This embodiment provides a scalp soothing and anti-dandruff composition, the formula of which is: 5 parts of climbazole, 3 parts of paeonol, 3 parts of decyl oxazolidinone, and 0.5 parts of a plant extract (a mixture of the grapefruit peel extract prepared in Preparation Example 1-1 and the white willow bark extract prepared in Preparation Example 2-1 in a mass ratio of 1:5).

[0102] Example 2

[0103] This embodiment provides a scalp soothing and anti-dandruff composition, the formula of which is: 1 part of climbazole, 5 parts of paeonol, 0.5 parts of decyl oxazolidinone, and 0.1 part of a plant extract (a mixture of the grapefruit peel extract prepared in Preparation Example 1-2 and the white willow bark extract prepared in Preparation Example 2-2 in a mass ratio of 1:1).

[0104] Example 3

[0105] This embodiment provides a scalp soothing and anti-dandruff composition, the formula of which is: 10 parts of climbazole, 0.5 parts of paeonol, 5 parts of decyl oxazolidinone and 1 part of a plant extract (a mixture of the grapefruit peel extract prepared in Preparation Example 1-3 and the white willow bark extract prepared in Preparation Example 2-3 in a mass ratio of 1:10).

[0106] Example 4

[0107] This embodiment provides a scalp soothing and anti-dandruff composition, which differs from Example 1 only in that the grapefruit peel extract prepared in Preparation Example 1-1 is replaced with an equal mass of grapefruit peel extract prepared in Preparation Example 1-4, and the remaining steps remain the same as in Example 1.

[0108] Example 5

[0109] This embodiment provides a scalp soothing and anti-dandruff composition, which differs from Example 1 only in that the grapefruit peel extract prepared in Preparation Example 1-1 is replaced with an equal mass of grapefruit peel extract prepared in Preparation Example 1-5, and the remaining steps remain the same as in Example 1.

[0110] Example 6

[0111] This embodiment provides a scalp soothing and anti-dandruff composition, which differs from Example 1 only in that the white willow bark extract prepared in Preparation Example 2-1 is replaced with an equal mass of the white willow bark extract prepared in Preparation Example 2-4, and the remaining steps remain the same as in Example 1.

[0112] Example 7

[0113] This embodiment provides a scalp soothing and anti-dandruff composition, which differs from Example 1 only in that the white willow bark extract prepared in Preparation Example 2-1 is replaced with an equal mass of the white willow bark extract prepared in Preparation Example 2-5, and the remaining steps remain the same as in Example 1.

[0114] Example 8

[0115] This embodiment provides a scalp soothing and anti-dandruff composition, which differs from Example 1 only in that the white willow bark extract prepared in Preparation Example 2-1 is replaced with an equal mass of the white willow bark extract prepared in Preparation Example 2-6, and the remaining steps remain the same as in Example 1.

[0116] Example 9

[0117] This embodiment provides a scalp soothing and anti-dandruff composition, which differs from Example 1 only in that the grapefruit peel extract is removed, that is, the plant extract is all the white willow bark extract prepared in Preparation Example 2-1, and the remaining steps are consistent with Example 1.

[0118] Example 10

[0119] This embodiment provides a scalp soothing and anti-dandruff composition, which differs from Example 1 only in that the white willow bark extract is removed, that is, the plant extract is entirely the grapefruit peel extract prepared in Preparation Example 1-1, and the remaining steps are consistent with Example 1.

[0120] Comparative Example 1

[0121] This comparative example provides a composition, which differs from Example 1 only in that climbazole is not included in the composition, and the reduced weight parts are supplemented by paeonol and decyl oxazolidinone in a mass ratio of 3:3, that is, the formula is: 5.5 parts of paeonol, 5.5 parts of decyl oxazolidinone and 0.5 parts of plant extract (a mixture of the grapefruit peel extract prepared in Preparation Example 1-1 and the white willow bark extract prepared in Preparation Example 2-1 in a mass ratio of 1:5).

[0122] Comparative Example 2

[0123] This comparative example provides a composition, which differs from Example 1 only in that the composition does not include paeonol, and the reduced weight parts are supplemented by climbazole and decyl oxazolidinone in a mass ratio of 5:3, that is, the formula is: 6.875 parts of paeonol, 4.125 parts of decyl oxazolidinone and 0.5 parts of plant extract (the grapefruit peel extract prepared in Preparation Example 1-1 and the white willow bark extract prepared in Preparation Example 2-1 are mixed in a mass ratio of 1:5).

[0124] Comparative Example 3

[0125] This comparative example provides a composition, which differs from Example 1 only in that the composition does not include decyl oxazolidinone, and the reduced weight parts are supplemented by climbazole and paeonol in a mass ratio of 5:3, that is, the formula is: 6.875 parts of climbazole, 4.125 parts of paeonol and 0.5 parts of plant extract (the grapefruit peel extract prepared in Preparation Example 1-1 and the white willow bark extract prepared in Preparation Example 2-1 are mixed in a mass ratio of 1:5).

[0126] Comparative Example 4

[0127] This comparative example provides a composition, which differs from Example 1 only in that the composition does not include plant extracts, that is, the formula of the composition is: 5 parts of climbazole, 3 parts of paeonol and 3 parts of decyl oxazolidinone.

[0128] Application Example 1

[0129] This application example provides a soothing anti-dandruff shampoo, the formula of which is: 5 parts of the composition, 15 parts of a surfactant, 2 parts of a hair conditioner, and 78 parts of a solvent.

[0130] Among them, the composition is the scalp soothing and anti-dandruff composition obtained in Example 1, the surfactants are sodium C14-C16 olefin sulfonate, sodium lauroyl sarcosinate, lauryl betaine and sodium lauryl glucose carboxylate in a mass ratio of 6:1:0.5:0.5; the hair conditioner is sodium polyaspartate, butylene glycol, panthenol and bisabolol in a mass ratio of 3:1:1:0.5; and the solvent is water.

[0131] The preparation process of the shampoo is:

[0132] (1) The solvent and the surfactant were mixed and homogenized at 80° C. and 20 rpm for 10 minutes to obtain a mixed solution A; the composition and the hair conditioner were mixed and stirred at 45° C. and 20 rpm for 10 minutes to obtain a mixed solution B;

[0133] (2) Mixed solution A and mixed solution B were mixed and stirred at 45° C. and 20 rpm for 10 min to obtain a soothing anti-dandruff shampoo.

[0134] Application Example 2

[0135] This application example provides a soothing anti-dandruff shampoo, the formula of which is: 3 parts of the composition, 10 parts of a surfactant, 5 parts of a hair conditioner, and 82 parts of a solvent.

[0136] Among them, the composition is the scalp soothing and anti-dandruff composition obtained in Example 2, the surfactants are sodium C14-C16 olefin sulfonate, sodium lauroyl sarcosinate, lauryl betaine and sodium lauryl glucose carboxylate in a mass ratio of 3:2:1:1; the hair conditioner is sodium polyaspartate, butylene glycol, panthenol and bisabolol in a mass ratio of 5:2:0.5:1; and the solvent is water.

[0137] The preparation process of the shampoo is:

[0138] (1) The solvent and the surfactant were mixed and homogenized at 85° C. and 10 rpm for 20 minutes to obtain a mixed solution A; the composition and the hair conditioner were mixed and stirred at 50° C. and 10 rpm for 20 minutes to obtain a mixed solution B;

[0139] (2) Mixed solution A and mixed solution B were mixed and stirred at 50° C. and 10 rpm for 20 min to obtain a soothing anti-dandruff shampoo.

[0140] Application Example 3

[0141] This application example provides a soothing anti-dandruff shampoo, the formula of which is: 1 part of the composition, 20 parts of a surfactant, 10 parts of a hair conditioner and 69 parts of a solvent.

[0142] Among them, the composition is the scalp soothing and anti-dandruff composition obtained in Example 3, the surfactants are sodium C14-C16 olefin sulfonate, sodium lauroyl sarcosinate, lauryl betaine and sodium lauryl glucose carboxylate in a mass ratio of 4:1:1:0.5; the hair conditioner is sodium polyaspartate, butylene glycol, panthenol and bisabolol in a mass ratio of 6:3:3:1; and the solvent is water.

[0143] The preparation process of the shampoo is:

[0144] (1) The solvent and the surfactant were mixed and homogenized at 75°C and 40 rpm for 5 minutes to obtain a mixed solution A; the composition and the hair conditioner were mixed and stirred at 40°C and 40 rpm for 5 minutes to obtain a mixed solution B;

[0145] (2) Mixed solution A and mixed solution B were mixed and stirred at 40° C. and 40 rpm for 5 min to obtain a soothing anti-dandruff shampoo.

[0146] Application Example 4-10

[0147] Application Examples 4-10 each provide a soothing and anti-dandruff shampoo, which differs from Application Example 1 only in that the scalp soothing and anti-dandruff composition obtained in Example 1 is replaced with the scalp soothing and anti-dandruff composition obtained in Examples 4-10 of equal mass, respectively.

[0148] Comparative Application Examples 1-4

[0149] Comparative Application Examples 1-4 each provide a shampoo, which differs from Application Example 1 only in that the scalp soothing and anti-dandruff composition obtained in Example 1 is replaced by the compositions obtained in Comparative Examples 1-4 of equal mass, respectively.

[0150] Test Example 1

[0151] Anti-dandruff effect test:

[0152] Dandruff is a condition characterized by excessive scalp keratinocyte proliferation, leading to excessive dandruff. Malassezia is a key factor in dandruff. The proliferation of Malassezia on the scalp causes excessive growth of the stratum corneum, which in turn causes abnormal shedding of keratinocytes in the form of white or gray scales. Increased dandruff is a mild manifestation of seborrheic dermatitis. The proliferation of Malassezia leads to oily scalp and severe dandruff, which in turn promotes the proliferation of Malassezia. The inhibitory effect of Malassezia is often used as a method to evaluate the efficacy of anti-dandruff products.

[0153] Experimental method: Samples were collected from the heads of normal people with dandruff using the scraping method, inoculated into culture plates, and cultured at 32°C for 10 days. The resulting Malassezia was streaked on the same culture plates to isolate single colonies, and Malassezia furfur was isolated after identification. Qualitative filter paper was punched into 5mm diameter circular filter paper pieces with a hole punch, sterilized by pressure steam, and several sterilized and dried sample pieces were taken. Sterile tweezers were used to dip equal amounts of shampoo from each application example and comparative application example onto the sample pieces, and the sample pieces were evenly spread. The activated Malassezia furfur was prepared into 1×10 7 A bacterial suspension (CFU / mL) was prepared by evenly smearing 0.5 mL of the suspension onto a culture medium plate. Test samples from each application example and comparative example, as well as one negative control sample (not containing the test shampoo), were placed on the plate. Sterile tweezers were used to gently press the sample against the plate surface. Cover the plate and incubate inverted in a 32°C incubator for 7 days. The diameter of the inhibition zone (mm) was measured using a vernier caliper. The test results are shown in Table 2.

[0154] Table 2

[0155]

[0156]

[0157] From the comparison of the data in Table 2, it can be seen that the soothing anti-dandruff shampoo involved in the present invention has a good inhibitory effect on Malassezia.

[0158] Comparison of the data from Application Example 1 with Comparative Application Examples 1-3 shows that the absence of any one of climbazole, paeonol, and decyloxazolidinone in the composition reduces the antibacterial effect to varying degrees. This indicates that climbazole, paeonol, and decyloxazolidinone exhibit significant synergistic effects in dandruff removal. Comparison of the data from Application Example 1 with Comparative Application Example 4 demonstrates that plant extracts can better regulate the ecological balance of the scalp, further enhancing the antidandruff efficacy of the composition.

[0159] From the comparison of the data of Application Example 1 and Application Examples 4-5, it can be seen that in the preparation process of grapefruit peel extract, ultrahigh pressure treatment is performed before vacuum decompression reflux extraction treatment, and the pressure of ultrahigh pressure treatment is controlled at 200-400 MPa, which can better promote the release of active ingredients and is more conducive to the prepared grapefruit peel extract to exert an auxiliary anti-dandruff effect.

[0160] From the comparison of the data of Application Example 1 and Application Examples 6-8, it can be seen that the use of a solution containing a low eutectic solvent to perform hot extraction on the white willow bark can better extract the anti-dandruff effective ingredients; in addition, using oxalic acid as a hydrogen bond donor and L-carnitine as a hydrogen bond acceptor can further improve the extraction effect of the effective ingredients.

[0161] From the comparison of the data of Application Example 1 and Application Examples 9-10, it can be seen that the grapefruit peel extract and the white willow bark extract have a significant synergistic effect in assisting the anti-dandruff effect.

[0162] Test Example 2

[0163] Evaluation of usage effect:

[0164] 140 volunteers suffering from dandruff and itchy scalp were selected and divided into 14 groups, with 10 participants in each group. Each group used the shampoo samples from each application example and the comparative application example once every night for two consecutive months. The evaluation criteria for anti-dandruff and anti-itching efficacy are shown in Table 3. The average score for each test sample was calculated, and the test results are shown in Table 4.

[0165] Table 3

[0166] score Improve the situation 5 Dandruff almost disappeared and itchy scalp problem disappeared 4 Dandruff is significantly reduced and itchy scalp problems are basically gone. 3 The amount of dandruff is reduced and the intervals between itching are prolonged. 2 Dandruff is slightly reduced and itching is slightly relieved 1 No improvement in dandruff and itchy scalp problems

[0167] Table 4

[0168]

[0169]

[0170] From the comparison of the data in Table 4, it can be seen that the soothing anti-dandruff shampoo of the present invention has excellent anti-dandruff and antipruritic effects.

[0171] Comparison of the data from Application Example 1 with Comparative Application Examples 1-3 shows that the absence of any one of climbazole, paeonol, and decyloxazolidinone in the composition reduces the antidandruff and antipruritic efficacy to varying degrees. This indicates that climbazole, paeonol, and decyloxazolidinone exhibit significant synergistic effects in both antidandruff and antipruritic effects. Comparison of the data from Application Example 1 with Comparative Application Example 4 demonstrates that plant extracts can better regulate the scalp's ecological balance, further enhancing the soothing effect of the composition.

[0172] From the comparison of the data of Application Example 1 and Application Examples 4-5, it can be seen that in the preparation process of grapefruit peel extract, ultrahigh pressure treatment is performed before vacuum decompression reflux extraction treatment, and the pressure of ultrahigh pressure treatment is controlled at 200-400 MPa. This can better promote the release of active ingredients and is more conducive to the prepared grapefruit peel extract to exert auxiliary anti-dandruff and antipruritic effects.

[0173] From the comparison of the data of Application Example 1 and Application Examples 6-8, it can be seen that the use of a solution containing a low eutectic solvent to perform hot extraction on the white willow bark can better extract the anti-dandruff effective ingredients; in addition, using oxalic acid as a hydrogen bond donor and L-carnitine as a hydrogen bond acceptor can further improve the extraction effect of the effective ingredients.

[0174] From the comparison of the data of Application Example 1 and Application Examples 9-10, it can be seen that the grapefruit peel extract and the white willow bark extract have a significant synergistic effect in assisting the anti-dandruff and antipruritic effects.

[0175] The applicant declares that the present invention is illustrated by the above-described embodiments, but the present invention is not limited to the above-described embodiments. This does not mean that the present invention must rely on the above-described embodiments in order to be implemented. Those skilled in the art should understand that any improvements to the present invention, equivalent replacements for raw materials in the present invention, additions of auxiliary ingredients, and selection of specific methods, etc., fall within the scope of protection and disclosure of the present invention.

[0176] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the scope of protection of the present invention.

[0177] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any appropriate manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A scalp soothing and anti-dandruff composition, characterized in that: The scalp soothing and anti-dandruff composition comprises climbazole, paeonol, decyl oxazolidinone and plant extracts.

2. The scalp soothing and anti-dandruff composition according to claim 1, characterized in that: The scalp soothing and anti-dandruff composition comprises, by weight, 1-10 parts of climbazole, 0.5-5 parts of paeonol, 0.5-5 parts of decyl oxazolidinone and 0.1-1 part of a plant extract.

3. The scalp soothing and anti-dandruff composition according to claim 1 or 2, characterized in that: The plant extracts include grapefruit peel extract and / or white willow bark extract; Preferably, the plant extracts include grapefruit peel extract and white willow bark extract; Preferably, the mass ratio of the grapefruit peel extract to the white willow bark extract is 1:(1-10).

4. The scalp soothing and anti-dandruff composition according to claim 3, characterized in that: The grapefruit peel extract is prepared by a preparation method comprising the following steps: The grapefruit peel raw material is mixed with water and subjected to ultrahigh pressure treatment to obtain a mixed liquid, and the mixed liquid is then subjected to vacuum decompression reflux extraction treatment to obtain the grapefruit peel extract.

5. The scalp soothing and anti-dandruff composition according to claim 4, characterized in that: The material-liquid ratio of the grapefruit peel raw material to water is 1:(5-20) g / mL; Preferably, the ultrahigh pressure treatment is performed at a pressure of 200-400 MPa and for a time of 5-10 min; Preferably, the vacuum degree of the vacuum decompression reflux extraction treatment is 0.03-0.07 MPa, the temperature is 40-60° C., and the time is 0.5-2 h.

6. The scalp soothing and anti-dandruff composition according to any one of claims 3 to 5, characterized in that: The white willow bark extract is prepared by a preparation method comprising the following steps: The white willow bark raw material is mixed with a solution containing a low eutectic solvent and subjected to hot extraction to obtain a white willow bark extract.

7. The scalp soothing and anti-dandruff composition according to claim 6, characterized in that: The raw materials for preparing the solution containing the deep eutectic solvent include the deep eutectic solvent and water; Preferably, the deep eutectic solvent is obtained by reacting oxalic acid and L-carnitine; Preferably, the molar ratio of oxalic acid to L-carnitine is (3-5):1; Preferably, the solution containing a deep eutectic solvent is prepared by a preparation method comprising the following steps: Mixing oxalic acid and L-carnitine, reacting at 70-90°C for 1-5 hours, cooling to 20-40°C, and mixing with water to obtain a solution containing a deep eutectic solvent; Preferably, the mass ratio of the deep eutectic solvent to water is (1-5):

1.

8. The scalp soothing and anti-dandruff composition according to claim 6 or 7, characterized in that: The material-liquid ratio of the white willow bark raw material to the solution containing the deep eutectic solvent is 1:(5-10) g / mL; Preferably, the temperature of the hot extraction is 50-65° C., and the time of the hot extraction is 0.5-2 h.

9. A soothing anti-dandruff shampoo, characterized in that: The soothing and anti-dandruff shampoo comprises the scalp soothing and anti-dandruff composition according to any one of claims 1 to 8, a surfactant, a hair conditioner and a solvent; Preferably, the surfactant comprises any one or a combination of at least two of sodium olefin sulfonate, sodium lauroyl sarcosinate, lauryl betaine or sodium lauryl glucose carboxylate; Preferably, the hair conditioning agent comprises any one or a combination of at least two of sodium polyaspartate, butylene glycol, panthenol or bisabolol; Preferably, the solvent comprises water; Preferably, the soothing and anti-dandruff shampoo comprises, by mass, 1-5 parts of the scalp soothing and anti-dandruff composition according to any one of claims 1 to 8, 10-20 parts of a surfactant, 1-10 parts of a hair conditioner, and 50-85 parts of a solvent.

10. A method for preparing the soothing anti-dandruff shampoo according to claim 9, characterized in that: The preparation method comprises: (1) mixing a solvent and a surfactant to obtain a mixed solution A; mixing and stirring the scalp soothing and anti-dandruff composition according to any one of claims 1 to 8 and a hair conditioner to obtain a mixed solution B; (2) mixing the mixed solution A and the mixed solution B to obtain the soothing anti-dandruff shampoo; Preferably, the temperature of the mixing and homogenization before obtaining the mixed solution A in step (1) is 75-85° C., the mixing and homogenization time is 5-20 min, and the mixing and homogenization speed is 10-40 rpm; Preferably, the mixing temperature before obtaining the mixed solution B in step (1) is 40-50° C., the mixing time is 5-20 min, and the mixing speed is 10-40 rpm; Preferably, the mixing temperature in step (2) is 40-50° C., the mixing time is 5-20 min, and the mixing speed is 10-40 rpm.

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