Acidic hydrogen peroxide alcohol hand sanitizer and preparation method thereof

Abstract

The invention discloses an acidic hydrogen peroxide alcohol hand disinfectant and a preparation method thereof, and relates to the technical field of disinfectants. The cleaning agent is prepared from the following components in percentage by mass: 0.1-3% of hydrogen peroxide, 0.05-1% of an acidity enhancer, 50-80% of an alcohol substance, 0.1-3% of glycerol, 0.1-5% of a film-forming agent, 0.1-2% of a repairing component, 0.02-1% of a stabilizer and the balance of deionized water, wherein the acidity enhancer is citric acid, lactic acid or malic acid, the film-forming agent is tara gum, tamarind gum or a sodium alginate derivative, and the repairing component is a plant stem cell extract, an acid algae extract or a sargassum muticum extract. According to the invention, three problems that a low-concentration hydrogen peroxide hand disinfectant, an alcohol hand disinfectant and a hydrogen peroxide quick-drying hand disinfectant cannot achieve an inactivation effect on non-enveloped viruses in the presence of organic pollutants, skin irritation is easily caused, and hydrogen peroxide is easily decomposed and fails in a system are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of hand disinfectants, and in particular to an acidic hydrogen peroxide alcohol hand disinfectant and a preparation method thereof. Background Art

[0002] With increasing emphasis on health and public health awareness, the demand for hand disinfection is increasing. This is especially true in public places like hospitals, schools, shopping malls, and public transportation, where people need convenient, fast, and effective hand sanitizers to keep their hands clean and prevent the spread of disease. In specialized work environments, such as food processing and pharmaceutical industries, disinfectants have even higher requirements. They must not only be effective, but also safe, non-toxic, harmless, biodegradable, easy to use, non-flammable, and non-explosive, and safe and convenient to transport and store.

[0003] Currently, alcohol-based hand sanitizers are commonly used. These hand sanitizers are effective against enveloped viruses because alcohol dissolves the lipid envelope surrounding them. The envelope is primarily composed of lipids and proteins, and alcohol can disrupt the lipid bilayer structure of the envelope, causing the enveloped virus to lose its integrity. This exposes components such as nucleic acids and proteins within the virus, resulting in the virus losing its ability to infect and ultimately being killed. However, for non-enveloped viruses, since they lack a lipid envelope, a structure easily damaged by alcohol, alcohol cannot dissolve the envelope to disrupt the overall structure of the virus. While alcohol may have some effect on some chemical bonds on the surface of the protein capsid or the spatial structure of the protein, this effect is often insufficient to completely destroy the virus's infectivity, making it difficult to effectively kill non-enveloped viruses.

[0004] In addition, traditional hand disinfectants have the following shortcomings: 1) Limitations of disinfection effect: Some traditional hand disinfectants have a limited bactericidal spectrum. For example, neutral quaternary ammonium compounds in hand disinfectants are not effective against fungi and pathogenic spores. Although aldehyde hand disinfectants have a wide bactericidal range and a long solution stability period, they are highly toxic and irritating, posing safety risks when used.

[0005] 2) Stability issues: For example, hydrogen peroxide-based hand disinfectants have poor stability, short sterilization duration, and can produce incomplete chemical reactions with most substances, affecting the disinfection effect.

[0006] 3) Adverse effects on the human body: Some hand sanitizers contain ingredients that are irritating and corrosive to the skin, and long-term use may cause harm to the body. For example, chlorine-containing disinfectants have a pungent odor, are irritating to the skin, and may also induce certain diseases. Commonly used high-concentration ethanol hand sanitizers are highly irritating and can easily trigger allergic reactions.

[0007] Therefore, in response to the problems existing in traditional hand disinfectants, it is necessary to develop a hand disinfectant that can effectively kill non-enveloped viruses, has strong stability, good bactericidal effect, and has no adverse effects on the human body, so as to facilitate mass production and market promotion. Summary of the Invention

[0008] The technical problem to be solved by the present invention is to overcome the shortcomings of the existing technology and provide an acidic hydrogen peroxide alcohol hand disinfectant and a preparation method thereof, which solves the three major problems of low-concentration hydrogen peroxide (≤3wt.%) hand disinfectants, alcohol hand disinfectants, and hydrogen peroxide quick-drying hand disinfectants, namely, the inactivation effect of non-enveloped viruses in the presence of organic pollutants, the high probability of causing skin irritation, and the easy decomposition and failure of hydrogen peroxide in the system.

[0009] The technical solution of the present invention is: On the one hand, the present invention provides an acidic hydrogen peroxide alcohol hand disinfectant composed of the following components in mass percentage: 0.1-3% hydrogen peroxide, 0.05-1% acid enhancer, 50-80% alcohol, 0.1-3% glycerol, 0.1-5% film-forming agent, 0.1-2% repair component, 0.02-1% stabilizer, and the balance is deionized water; wherein, the acid enhancer is citric acid, lactic acid or malic acid, the film-forming agent is tara gum, tamarind gum or a sodium alginate derivative, and the repair component is a plant stem cell extract, an acid algae extract or a sea millet extract.

[0010] Preferably, the alcohol substance is ethanol, n-propanol or isopropanol.

[0011] Preferably, the stabilizer is sodium pyrophosphate, sodium stannate or 8-hydroxyquinoline.

[0012] On the other hand, the present invention provides a method for preparing the above-mentioned acidic hydrogen peroxide alcohol hand disinfectant, comprising the following steps: S1: Add alcohol to deionized water; S2: Add glycerol; S3: Add hydrogen peroxide and mix well; S4: Add acid enhancer and mix well; S5: Add repair ingredients, film former and stabilizer and mix well; S6: Filling and packaging to obtain the acidic hydrogen peroxide alcohol hand disinfectant.

[0013] Preferably, in step S3, stirring is performed during mixing, with a stirring speed of 40-200 rpm and a stirring time of 10-15 min.

[0014] Preferably, in step S4, stirring is performed during mixing, with a stirring speed of 40-200 rpm and a stirring time of 5-10 min.

[0015] Preferably, in step S5, stirring is performed during mixing, the stirring speed is 60-200 rpm, and the stirring time is more than 30 minutes.

[0016] Compared with the prior art, the present invention has the following beneficial effects: 1. In the hand sanitizer of the present invention, alcohols have a strong bactericidal effect, quickly killing a variety of bacteria and viruses. Alcohols are also volatile, allowing hands to dry quickly after use, making them convenient for daily use. Furthermore, under acidic conditions, alcohols can accelerate the dissolution of viral capsid lipids and protein denaturation. Hydrogen peroxide has a strong oxidizing ability and a broad bactericidal spectrum, effectively killing a variety of bacterial vegetative forms, fungi, and viruses. Furthermore, under acidic conditions, hydrogen peroxide decomposes more rapidly, producing more hydroxyl radicals, which enhances the oxidizing ability of the hand sanitizer and prolongs its effectiveness. Furthermore, the present invention also incorporates an acidic enhancer into the hand sanitizer, which can destabilize viral structures in the pH environment provided by the present invention. Therefore, the present invention combines hydrogen peroxide, an alcohol, and an acidic enhancer to prepare a hand sanitizer, leveraging their synergistic bactericidal effects and improving disinfection effectiveness. The hand disinfectant of the present invention solves three major problems: low-concentration hydrogen peroxide (≤3wt.%) hand disinfectants, alcohol hand disinfectants, hydrogen peroxide quick-drying hand disinfectants and other single or compound hand disinfectants cannot inactivate non-enveloped viruses in the presence of organic pollutants, are very likely to cause skin irritation, and hydrogen peroxide is easily decomposed and ineffective in the system.

[0017] 2. Alcohols are volatile. When applied to the skin, they evaporate rapidly, removing moisture from the skin's surface. This leaves the skin's surface cells relatively dehydrated, leading to dryness, tightness, and discomfort—a clear manifestation of alcohol irritation. The acidic enhancer introduced in the present invention slowly dissolves lipids between cells in the stratum corneum, affecting the normal metabolism of the stratum corneum and disrupting the skin's barrier function. This can cause skin sensitivity and lead to symptoms such as dryness, itching, and redness. Furthermore, an imbalance in the skin's pH disrupts the metabolic processes of skin cells, weakening the skin's barrier function. Hydrogen peroxide has strong oxidizing properties. When in contact with the skin, it reacts with various biomolecules within the skin tissue. Simultaneously, it also oxidizes lipid components in skin cells, effectively disrupting the cells' normal physiological functions. Therefore, the alcohol, acidic enhancer, and hydrogen peroxide in the hand disinfectant of the present invention all have a certain degree of irritation. This triple irritation poses a greater challenge to skin care, making this problem unsolvable with simple moisturizing or repairing methods. To this end, the present invention introduces glycerin, repair ingredients, and film-forming agents, and sets up a three-stage "moisturizing + repairing + isolating" technology to ensure that the product is non-irritating to use, keep the hands in a healthy state, and perfectly solve the problem of triple irritation. Among them, the moisturizing technology maintains the moisture content of the skin, and the film-forming technology reduces water evaporation. The film formed by the film-forming technology can better lock the moisture adsorbed by the moisturizing ingredients, and the presence of the moisturizing ingredients also makes the skin more hydrated after film formation, and will not cause skin dryness due to a simple physical barrier. While repairing the damaged skin barrier, the repair technology also helps to improve the skin's moisturizing ability, because the repaired skin barrier can better lock in moisture. Moreover, the repaired skin is also more adaptable to the physical barrier effect brought about by the film-forming technology, and there will be no adverse reactions to the film-forming due to excessive skin sensitivity. Therefore, the moisturizing technology and the isolating technology provide a relatively stable and suitable skin environment for the repair technology, which is conducive to the better functioning of the repair ingredients, promotes the regeneration of skin cells and the repair of damaged barriers, and always maintains the health of the hand skin.

[0018] 3. The hand disinfectant of the present invention solves the problems of poor stability and short sterilization duration of hydrogen peroxide hand disinfectants by adding a stabilizer, thereby greatly enhancing the stability of the sterilization effect of the hand disinfectant. DETAILED DESCRIPTION

[0019] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention.

[0020] Example 1 The acidic hydrogen peroxide alcohol hand disinfectant of this embodiment is composed of the following components in mass percentage: 0.1% hydrogen peroxide, 0.05% citric acid, 50% ethanol, 0.1% glycerol, 0.1% tara gum, 0.1% plant stem cell extract, 0.02% sodium pyrophosphate, and the balance is deionized water.

[0021] The preparation method of the acidic hydrogen peroxide alcohol hand disinfectant of this embodiment comprises the following steps: S1: Add ethanol to deionized water; S2: Add glycerol; S3: Add hydrogen peroxide and stir at 40 rpm for 15 min to mix evenly; S4: Add citric acid and stir at 40 rpm for 10 min to mix evenly; S5: Add plant stem cell extract, tara gum and sodium pyrophosphate, and stir at 60 rpm for 90 minutes to mix evenly; S6: Filling and packaging to obtain the acidic hydrogen peroxide alcohol hand disinfectant.

[0022] Example 2 The acidic hydrogen peroxide alcohol hand disinfectant of this embodiment is composed of the following components in percentage by mass: 1.5% hydrogen peroxide, 0.5% lactic acid, 75% n-propanol, 2% glycerol, 3% tamarind gum, 1% acid algae extract, 0.5% sodium stannate, and the balance is deionized water.

[0023] The preparation method of the acidic hydrogen peroxide alcohol hand disinfectant of this embodiment comprises the following steps: S1: Add n-propanol to deionized water; S2: Add glycerol; S3: Add hydrogen peroxide and stir at 100 rpm for 12 minutes to mix evenly; S4: Add lactic acid and stir at 100 rpm for 8 min to mix evenly; S5: Add tamarind gum, acid algae extract, and sodium stannate, and stir at 100 rpm for 60 minutes to mix evenly; S6: Filling and packaging to obtain the acidic hydrogen peroxide alcohol hand disinfectant.

[0024] Example 3 The acidic hydrogen peroxide alcohol hand disinfectant of this embodiment is composed of the following components in percentage by mass: 3% hydrogen peroxide, 1% malic acid, 80% isopropyl alcohol, 3% glycerol, 5% sodium alginate derivative, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0025] The preparation method of the acidic hydrogen peroxide alcohol hand disinfectant of this embodiment comprises the following steps: S1: Add isopropyl alcohol to deionized water; S2: Add glycerol; S3: Add hydrogen peroxide and stir at 200 rpm for 10 min to mix evenly; S4: Add malic acid and stir at 200 rpm for 5 min to mix evenly; S5: adding sodium alginate derivative, sea millet extract, and 8-hydroxyquinoline, stirring at 200 rpm for 30 min to mix evenly; S6: Filling and packaging to obtain the acidic hydrogen peroxide alcohol hand disinfectant.

[0026] Comparative Example 1 The hand disinfectant of Comparative Example 1 is composed of the following components in percentage by mass: 80% isopropyl alcohol, 3% glycerol, 5% sodium alginate derivative, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0027] The preparation method of the hand disinfectant in Comparative Example 1 is the same as that in Example 3.

[0028] Comparative Example 2 The hand disinfectant of Comparative Example 2 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 3% glycerol, 5% sodium alginate derivative, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0029] The preparation method of the hand disinfectant in Comparative Example 2 is the same as that in Example 3.

[0030] Comparative Example 3 The hand disinfectant of Comparative Example 3 is composed of the following components in percentage by mass: 1% malic acid, 3% glycerol, 5% sodium alginate derivative, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0031] The preparation method of the hand disinfectant in Comparative Example 3 is the same as that in Example 3.

[0032] Comparative Example 4 The hand disinfectant of Comparative Example 4 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 1% malic acid, 3% glycerol, 5% sodium alginate derivative, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0033] The preparation method of the hand disinfectant in Comparative Example 4 is the same as that in Example 3.

[0034] Comparative Example 5 The hand disinfectant of Comparative Example 5 is composed of the following components in percentage by mass: 1% malic acid, 80% isopropyl alcohol, 3% glycerol, 5% sodium alginate derivative, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0035] The preparation method of the hand disinfectant in Comparative Example 5 is the same as that in Example 3.

[0036] Comparative Example 6 The hand disinfectant of Comparative Example 6 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 80% isopropyl alcohol, 3% glycerol, 5% sodium alginate derivative, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0037] The preparation method of the hand disinfectant in Comparative Example 6 is the same as that in Example 3.

[0038] The hand disinfectants of Examples 1-3 and Comparative Examples 1-6 were tested for their bactericidal efficacy. The quantitative killing assays for Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were conducted in accordance with Section 2.1.1.7, "Quantitative Bacterial Killing Test," of the Technical Specifications for Disinfection (2002 edition). The quantitative killing assay for Candida albicans was conducted in accordance with Section 2.1.1.9, "Fungicide Test," of the Technical Specifications for Disinfection (2002 edition). The inactivation assays for poliovirus and EV71 were conducted in accordance with Section 2.1.1.10.7, "Poliovirus Inactivation Test," of the Technical Specifications for Disinfection (2002 edition). The experiment involved mixing 100 mL of an organic interfering substance (3 wt.% bovine serum albumin) with 100 mL of the virus stock solution, incubating in a 20°C ± 1°C water bath for 5 minutes, adding 0.8 mL of the hand disinfectant to be tested, and immediately mixing thoroughly while recording the time. After 1 minute, 0.1 mL was immediately removed and added to the D / E neutralizing broth, mixed thoroughly, and then tested for bactericidal efficacy. The test results are shown in Table 1: Table 1 Test results of the bactericidal effects of the hand disinfectants of Examples 1-3 and Comparative Examples 1-6

[0039] It can be seen from the test results in Table 1 that when one or two of hydrogen peroxide, acidic enhancers and alcohols are used in Comparative Examples 1-6, the effects are single. Only when the three are used simultaneously, the acidic enhancer plays a pre-destructive role, hydrogen peroxide enhances the oxidation effect, and the alcohol aids in fat dissolution and protein denaturation, forming a triple synergistic mechanism with better effects.

[0040] Furthermore, based on Comparative Example 5, the present invention adjusts the pH of the hand disinfectant by using citric acid or sodium hydroxide, and tests the bactericidal effect of the hand disinfectant obtained after adjustment. The test results are shown in Table 2: Table 2 Test results of bactericidal effects of hand disinfectants with different pH values

[0041] It can be seen from the test results in Table 2 that pH has a certain influence on the bactericidal effect of hand disinfectants. When the pH is weakly acidic or alkaline, the disinfection effect will be improved, but the predetermined bactericidal effect cannot be achieved by simply adjusting the pH.

[0042] In addition, in order to demonstrate the effect of hydrogen peroxide, the present invention adjusted the content of hydrogen peroxide on the basis of Comparative Example 6, and tested the bactericidal effect of the hand disinfectant obtained after the adjustment. The test results are shown in Table 3: Table 3 Test results of the bactericidal effect of hand disinfectants with different hydrogen peroxide dosages

[0043] It can be seen from the test results in Table 3 that as the hydrogen peroxide content in the hand disinfectant increases, the inactivation effect on polio virus and EV71 virus gradually increases.

[0044] Comparative Example 7 The hand disinfectant of Comparative Example 7 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 1% malic acid, 80% isopropyl alcohol, 3% glycerol, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0045] The preparation method of the hand disinfectant in Comparative Example 7 is the same as that in Example 3.

[0046] Comparative Example 8 The hand disinfectant of Comparative Example 8 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 1% malic acid, 80% isopropyl alcohol, 5% sodium alginate derivative, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0047] The preparation method of the hand disinfectant in Comparative Example 8 is the same as that in Example 3.

[0048] Comparative Example 9 The hand disinfectant of Comparative Example 9 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 1% malic acid, 80% isopropyl alcohol, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0049] The preparation method of the hand disinfectant in Comparative Example 9 is the same as that in Example 3.

[0050] Comparative Example 10 The hand disinfectant of Comparative Example 10 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 1% malic acid, 80% isopropyl alcohol, 3% glycerol, 5% sodium alginate derivative, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0051] The preparation method of the hand disinfectant of Comparative Example 10 is the same as that of Example 3.

[0052] Comparative Example 11 The hand disinfectant of Comparative Example 11 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 1% malic acid, 80% isopropyl alcohol, 3% glycerol, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0053] The preparation method of the hand disinfectant of Comparative Example 11 is the same as that of Example 3.

[0054] Comparative Example 12 The hand disinfectant of Comparative Example 12 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 1% malic acid, 80% isopropyl alcohol, 5% sodium alginate derivative, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0055] The preparation method of the hand disinfectant of Comparative Example 12 is the same as that of Example 3.

[0056] The skin care effect test was conducted on the hand disinfectants of Examples 1-3 and Comparative Examples 7-12: Transepidermal water evaporation was tested using a German CK Cosmetic Efficacy Evaluator with a TM300 probe; stratum corneum moisture content was tested using a German CK Cosmetic Efficacy Evaluator with a CM825 probe. Skin irritation testing: 30 volunteers (half male and half female, average age 22-30) applied six disinfectants to their left or right hand for 2 minutes over an area larger than 2cm x 2cm. Sensory evaluation was performed using a skin irritation index ranging from 0 to 2, with higher values indicating greater skin irritation. Acute oral toxicity testing was conducted using the acute oral toxicity test method specified in 2.3.1 of the "Technical Specifications for Disinfection" (2002 edition).

[0057] The test results are shown in Table 4: Table 4 Skin care effect test results of hand disinfectants of Examples 1-3 and Comparative Examples 7-12

[0058] As shown in Table 4, when only one of the film-forming agent, glycerin, and repairing ingredient was used in Comparative Examples 7-9, the hand disinfectants had poor skin care effects, significantly increased water evaporation, significantly reduced stratum corneum moisture content, and increased the skin irritation index from 0 to a maximum of 0.42. Comparative Examples 10-12, when two of the three ingredients were used, had better skin care effects than Comparative Examples 7-9, but also significantly increased water evaporation compared to Example 3, significantly reduced stratum corneum moisture content, and increased the skin irritation index from 0 to a maximum of 0.28.

[0059] In summary, the present invention implements a three-stage "moisturizing + repairing + isolating" technology by adding glycerin, a repairing ingredient, and a film-forming agent, ensuring that the hand disinfectant product is non-irritating and keeps hands healthy. The moisturizing technology maintains the skin's moisture content, while the film-forming technology reduces water evaporation. The film formed by the film-forming technology can better lock in the moisture absorbed by the moisturizing ingredient. The presence of the moisturizing ingredient also makes the skin more hydrated after film formation, preventing skin dryness caused by a simple physical barrier. While repairing the damaged skin barrier, the repairing technology also helps improve the skin's moisturizing ability, as the repaired skin barrier can better lock in moisture. Furthermore, the repaired skin is more adaptable to the physical barrier effect brought about by the film-forming technology, and there will be no adverse reactions to the film-forming technology due to excessive skin sensitivity. Therefore, the moisturizing technology and the isolating technology provide a relatively stable and suitable skin environment for the repairing technology, which is conducive to the repairing ingredients to better function, promote the regeneration of skin cells and the repair of damaged barriers, and always maintain the health of the hand skin.

[0060] Comparative Example 13 The hand disinfectant of Comparative Example 13 is composed of the following components in percentage by mass: 1.5% hydrogen peroxide, 0.5% lactic acid, 75% n-propanol, 2% glycerol, 3% tamarind gum, 1% acid algae extract, and the balance being deionized water.

[0061] The preparation method of the hand disinfectant of Comparative Example 13 is the same as that of Example 2.

[0062] According to Section 2.2.3 of the "Technical Specifications for Disinfection" (2002 edition), which covers the stability testing of disinfectant products, the hand disinfectants of Examples 1-3 and Comparative Example 13 were tested for stability. If the hydrogen peroxide content decreases by no more than 10% over 14 days at 54°C, the disinfectants are considered stable and have a shelf life of one year. If the hydrogen peroxide content decreases by no more than 10% over 90 days at 37°C, the disinfectants are considered stable and have a shelf life of two years. The test results are shown in Table 5. Table 5 Test results of the stability of hand disinfectants in Examples 1-3 and Comparative Example 13

[0063] As shown in Table 5, Comparative Example 13, in which no stabilizer was added, resulted in a hydrogen peroxide content decrease of 18% after 12 months of storage, and a 30% decrease after 24 months of storage, significantly higher than in Examples 1-3. This indicates that the stability of the hand sanitizer failed the standard. This is because the stabilizer added in the present invention complexes metal ions released from raw materials, production equipment, water, and packaging materials, deactivating their catalytic activity. This reduces the decomposition of hydrogen peroxide and improves its stability.

[0064] Comparative Example 14 The hand disinfectant of Comparative Example 14 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 1.2% malic acid, 80% isopropyl alcohol, 3% glycerol, 5% sodium alginate derivative, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0065] The preparation method of the hand disinfectant of Comparative Example 14 is the same as that of Example 3.

[0066] Comparative Example 15 The hand disinfectant of Comparative Example 15 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 1% malic acid, 80% isopropyl alcohol, 3% glycerol, 5.5% sodium alginate derivative, 2% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0067] The preparation method of the hand disinfectant of Comparative Example 15 is the same as that of Example 3.

[0068] Comparative Example 16 The hand disinfectant of Comparative Example 16 is composed of the following components in percentage by mass: 3% hydrogen peroxide, 1% malic acid, 80% isopropyl alcohol, 3% glycerol, 5% sodium alginate derivative, 2.5% sea millet extract, 1% 8-hydroxyquinoline, and the balance is deionized water.

[0069] The preparation method of the hand disinfectant of Comparative Example 16 is the same as that of Example 3.

[0070] The hand disinfectants of Comparative Examples 14-16 were tested for skin care effects. The test results of Examples 1-3 and Comparative Examples 14-16 are shown in Table 6: Table 6 Skin care effect test results of Examples 1-3 and Comparative Examples 14-16

[0071] As can be seen from Table 6, compared with Example 3, the excessive addition of the acidic enhancer in Comparative Example 14 not only increases transepidermal water evaporation, but also reduces the moisture content of the stratum corneum and significantly increases skin irritation. The excessive addition of the film-forming agent in Comparative Example 15 increases transepidermal water evaporation, reduces the moisture content of the stratum corneum, and increases skin irritation. This is because excessive addition of the film-forming agent affects the skin's respiratory system, leaving the skin in a subhealthy state. The excessive addition of the repair component in Comparative Example 16 increases transepidermal water evaporation, reduces the moisture content of the stratum corneum, and increases skin irritation. This is because excessive addition of the repair component may form an overly dense film on the skin surface, hindering the penetration and loss of moisture, while also affecting the skin's own respiration and metabolism. In the long term, this may lead to insufficient moisture supply within the skin, thereby causing dryness.

Claims

1. Acidic hydrogen peroxide alcohol hand disinfectant, characterized in that, The invention is composed of the following components in percentage by mass: 0.1-3% hydrogen peroxide, 0.05-1% acid enhancer, 50-80% alcohol, 0.1-3% glycerol, 0.1-5% film former, 0.1-2% repair component, 0.02-1% stabilizer, and the balance is deionized water; wherein the acid enhancer is citric acid, lactic acid or malic acid, the film former is tara gum, tamarind gum or sodium alginate derivative, and the repair component is plant stem cell extract, acid algae extract or sea millet extract.

2. The acidic hydrogen peroxide alcohol hand disinfectant according to claim 1, characterized in that The alcohol substance is ethanol, n-propanol or isopropanol.

3. The acidic hydrogen peroxide alcohol hand disinfectant according to claim 1, characterized in that The stabilizer is sodium pyrophosphate, sodium stannate or 8-hydroxyquinoline.

4. The method for preparing the acidic hydrogen peroxide alcohol hand disinfectant according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1: Add alcohol to deionized water; S2: Add glycerol; S3: Add hydrogen peroxide and mix well; S4: Add acid enhancer and mix well; S5: Add repair ingredients, film former and stabilizer and mix well; S6: Filling and packaging to obtain the acidic hydrogen peroxide alcohol hand disinfectant.

5. The method for preparing the acidic hydrogen peroxide alcohol hand disinfectant according to claim 4, wherein: In step S3, stirring is performed during mixing, with a stirring speed of 40-200 rpm and a stirring time of 10-15 min.

6. The method for preparing the acidic hydrogen peroxide alcohol hand disinfectant according to claim 4, wherein: In step S4, stirring is performed during mixing, with a stirring speed of 40-200 rpm and a stirring time of 5-10 min.

7. The method for preparing the acidic hydrogen peroxide alcohol hand disinfectant according to claim 4, wherein: In step S5, stirring is performed during mixing, with a stirring speed of 60-200 rpm and a stirring time of more than 30 minutes.

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