Compound essential oil with sleep aiding effect and preparation method thereof
Through the compound essential oil formula composed of lavender essential oil, combined with sustained release agents and horn root extract, the problems of fast volatility and poor absorption are solved, and the stable release and efficient absorption of essential oils are achieved, which significantly improves sleep quality.
Patent Information
- Application Number
- CN202510683510.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-26
- Publication Date
- 2025-08-08
AI Technical Summary
The existing compound essential oils volatilize too quickly, have poor absorption, strong irritation of ingredients, and have uneven sleep aiding effects, and lack safe and effective sleep aiding solutions.
The ratio of lavender essential oil, rosemary leaf oil, jujube kernel essential oil, gardenia essential oil, bergamot oil, horn root extract and sustained release agent and emulsifier is adopted. By preparing sustained release agents, the absorption efficiency and slow release of essential oils are improved, and combined with horn root extract, the absorption and utilization effect of human body is improved.
It realizes stable release and efficient absorption of essential oils, significantly improves sleep quality, prolongs fragrance retention time, and has high stability and long storage time at different temperatures.
Smart Images
Figure BDA0005419951650000051 
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Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of compound essential oils, and particularly relates to a compound essential oil with a sleep-inducing effect and a preparation method thereof. Background Art
[0002] With the accelerating pace of life, more and more people are experiencing sleep disorders. Furthermore, studies have shown that long-term insomnia can easily lead to health problems such as Alzheimer's disease, hypertension, coronary heart disease, arrhythmias, and depression. Interventions for insomnia primarily include medication and non-drug treatments. However, medications can be addictive and have side effects.
[0003] Traditional Chinese Medicine (TCM) generally believes that aromatherapy can disperse and invigorate qi, strengthen blood circulation, and unclog meridians. Aromatherapy has gained widespread popularity due to its significant effectiveness, safety, affordability, and ease of use. Aromatherapy works by inhaling aroma molecules through the nasal cavity and reaching the brain's limbic system, stimulating the central nervous system to release neurotransmitters, which participate in neuromodulation, resulting in muscle relaxation and a euphoric mood.
[0004] Currently, compound essential oils have the following technical problems: rapid volatilization, poor absorption, strong irritation of ingredients, and uneven sleep-inducing effects. Therefore, seeking a safe and effective sleep-inducing compound essential oil has become a research focus within the industry. Summary of the Invention
[0005] In order to overcome the deficiencies of the prior art, the first object of the present invention is to provide a compound essential oil with sleep-inducing efficacy, which can improve sleep quality.
[0006] The second object of the present invention is to provide a method for preparing a compound essential oil having a sleep-inducing effect, which has a simple process.
[0007] In order to achieve the above object, the technical solution adopted by the present invention is:
[0008] A compound essential oil with a sleep-inducing effect is prepared from the following raw materials in parts by weight: 5-10 parts of lavender essential oil, 3-5 parts of rosemary leaf oil, 1-5 parts of jujube seed essential oil, 2-5 parts of gardenia essential oil, 1-3 parts of bergamot oil, 1-3 parts of hornwort root extract, 0.5-1 part of a sustained-release agent, 1-2.5 parts of an emulsifier, and 10-20 parts of water.
[0009] Preferably, the preparation process of the sustained-release agent is as follows:
[0010] (1) adding diatomaceous earth to a sodium hydroxide solution and stirring the solution, filtering, washing, drying, and then calcining the solution to obtain pretreated diatomaceous earth;
[0011] (2) adding sodium carbonate to a zinc chloride solution for heating reaction, and performing aging treatment at room temperature after the reaction is completed to obtain a mixed solution;
[0012] (3) adding the diatomaceous earth pretreated in step (1) to water, and then adding the mixed solution in step (2) to carry out a reaction. After the reaction is completed, the mixture is aged at room temperature to obtain a sustained-release agent.
[0013] Preferably, the mass ratio of the diatomaceous earth to the sodium hydroxide solution in step (1) is 1:(10-15); the concentration of the sodium hydroxide solution is 5-10%; the stirring temperature is 65-75°C, and the stirring time is 1.5-2.5h; the calcination temperature is 300-400°C, and the calcination time is 2.5-3.5h.
[0014] Preferably, the dosage ratio of the sodium carbonate and zinc chloride solution in step (2) is (1-5) g: (800-900) mL; the concentration of the zinc chloride solution is 0.1-0.5 mol / L; the temperature of the heating reaction is 55-65° C., and the heating reaction time is 2.5-3.5 h; and the aging treatment time is 48-52 h.
[0015] Preferably, the mass ratio of the pretreated diatomaceous earth to the mixed solution in step (3) is 1:(1-4); the reaction temperature is 65-75°C, the reaction time is 3.5-4.5h; and the aging treatment time is 22-24h.
[0016] Preferably, the emulsifier is Tween-80 or Span-20.
[0017] Preferably, the compound essential oil is used by any one or more of spraying, applying, and massaging.
[0018] The preparation method of the above-mentioned compound essential oil with sleep-inducing effect comprises the following steps:
[0019] (a) weighing each raw material according to the weight ratio, mixing lavender essential oil, rosemary leaf oil, jujube seed essential oil, gardenia essential oil, bergamot oil, and smilax glabra root extract to obtain a mixture A;
[0020] (b) adding the sustained-release agent to water and mixing uniformly to obtain a sustained-release agent solution;
[0021] (c) adding mixture A to the sustained-release agent solution and stirring uniformly, allowing to stand, filtering, and vacuum drying, and then adding an emulsifier for homogenization to obtain the compound essential oil with sleep-inducing efficacy.
[0022] Preferably, the stirring temperature in step (c) is 35-45° C., and the stirring time is 2.5-3.5 h.
[0023] Preferably, the homogenization conditions in step (c) are as follows: pressure of 0.05-0.15 MPa, time of 10-15 min.
[0024] Compared with the prior art, the beneficial effects of the present invention are mainly:
[0025] 1. A sustained-release agent is added to the compound essential oil of the present invention. This sustained-release agent not only improves the absorption efficiency of the active ingredient essential oil but also achieves a slow release of the active ingredient essential oil. The results of a 72-hour sustained-release test indicate that the compound essential oil obtained by the present invention can maintain a stable release rate. This may be because the sustained-release agent is first heated and calcined with an alkaline solution to increase its internal pore structure, and then modified with a zinc chloride solution to form pillars to increase its specific surface area and stability, further improving its sustained-release performance and extending the fragrance retention time of the essential oil. Furthermore, the modified compound essential oil with zinc chloride can also enhance the antibacterial properties of the compound essential oil.
[0026] 2. The compound essential oil of the present invention further contains an extract from the root of the hornwort. The sleep quality and absorption results indicate that the addition of the extract from the root of the hornwort can enhance the absorption and utilization of the essential oil by the human body, further enhance the sleep-inducing effect, and improve sleep quality.
[0027] 3. The compound essential oil of the present invention has no precipitation or color change when placed at 5° C., 25° C., and 35° C. for 15 days, has a long storage time, and is highly stable. DETAILED DESCRIPTION
[0028] The technical solution of the present invention will be further described below in conjunction with specific embodiments. However, it should be understood by those skilled in the art that the following examples are only intended to illustrate the present invention and should not be construed as limiting the present invention. Specific conditions not specified in the examples are to be followed according to conventional conditions or the conditions recommended by the manufacturer. All reagents or instruments used, unless otherwise specified, are conventional products obtained from commercial channels.
[0029] The preparation method of lavender essential oil of the present invention is as follows:
[0030] Crush the lavender stems and leaves, pass them through a 200-mesh sieve, add water at a solid-liquid ratio of 1g:20mL, soak for 18 hours, heat to boiling and reflux for 3 hours, and collect the distillate; add sodium chloride to the distillate and let it stand for 12 hours. The concentration of sodium chloride in the distillate is 2wt%, collect the oil phase, dry it over anhydrous sodium sulfate, and filter it to obtain the product.
[0031] The preparation methods of jujube seed essential oil and gardenia essential oil are the same as those of lavender essential oil.
[0032] The preparation method of rosemary leaf oil is as follows:
[0033] Crush the rosemary leaves, pass through a 20-mesh sieve, add water at a solid-liquid ratio of 1g:10mL, mix evenly, distill for 4h, let stand and separate to obtain the supernatant, dry the supernatant over anhydrous sodium sulfate, and filter to obtain the product.
[0034] Bergamot oil is non-photosensitive bergamot oil.
[0035] The preparation method of the extract of the root of the oxalis flower is as follows:
[0036] The root of the Herba Cynoglossi was crushed and mixed with ethanol solution at a material-liquid ratio of 1:8, and reflux extraction was performed 3 times, each time for 2 hours. The obtained extracts were combined and concentrated under reduced pressure to form a concentrated solution, and then petroleum ether with an equal volume of the concentrated solution was added for extraction to obtain the Herba Cynoglossi root extract.
[0037] Example
[0038] Example 1
[0039] Example 1 provides a compound essential oil with a sleep-inducing effect, which is composed of the following raw materials in the following weight ratios: 8 parts of lavender essential oil, 4 parts of rosemary leaf oil, 2 parts of jujube seed essential oil, 3 parts of gardenia essential oil, 2 parts of bergamot oil, 2 parts of smilax china root extract, 0.6 parts of a sustained-release agent, 2 parts of Tween-80, and 15 parts of water.
[0040] The preparation process of the above-mentioned sustained-release agent is as follows:
[0041] (1) adding diatomaceous earth to sodium hydroxide solution at a mass ratio of 1:12, stirring at 60°C for 2 hours, filtering, washing, drying, and calcining at 350°C for 3 hours to obtain pretreated diatomaceous earth;
[0042] (2) Sodium carbonate was added to a 0.3 mol / L zinc chloride solution at a ratio of 2 g to 850 mL, and the mixture was heated at 60° C. for 3 h. After the reaction was completed, the mixture was aged at room temperature for 50 h to obtain a mixed solution;
[0043] (3) The pretreated diatomaceous earth of step (1) was added to water at a mass ratio of 1:2 to the mixed solution, and the mixed solution of step (2) was added, and the mixture was reacted at a constant temperature of 70° C. for 4 h. After the reaction was completed, the mixture was aged at room temperature for 23 h to obtain a sustained-release agent.
[0044] Example 1 also provides a method for preparing a compound essential oil having a sleep-inducing effect, which is as follows:
[0045] (a) weighing each raw material according to the weight ratio, mixing lavender essential oil, rosemary leaf oil, jujube seed essential oil, gardenia essential oil, bergamot oil, and smilax glabra root extract to obtain a mixture A;
[0046] (b) adding the sustained-release agent to water and mixing uniformly to obtain a sustained-release agent solution;
[0047] (c) Adding mixture A to the sustained-release agent solution, stirring at 40° C. for 3 h, allowing to stand, filtering, and vacuum drying, then adding Tween-80, and homogenizing at 0.1 MPa for 12 min to obtain the compound essential oil with sleep-inducing efficacy.
[0048] Example 2
[0049] Example 2 provides a compound essential oil with a sleep-inducing effect, which is composed of the following raw materials in the following weight ratios: 5 parts of lavender essential oil, 3 parts of rosemary leaf oil, 1 part of jujube seed essential oil, 2 parts of gardenia essential oil, 1 part of bergamot oil, 1 part of smilax china root extract, 0.5 parts of a sustained-release agent, 1 part of Span-20, and 10 parts of water.
[0050] The preparation process of the above-mentioned sustained-release agent is as follows:
[0051] (1) adding diatomaceous earth to sodium hydroxide solution at a mass ratio of 1:10, stirring at 65°C for 2.5 hours, filtering, washing, drying, and calcining at 300°C for 3.5 hours to obtain pretreated diatomaceous earth;
[0052] (2) Sodium carbonate was added to a 0.1 mol / L zinc chloride solution at a ratio of 1 g to 800 mL, and the mixture was heated at 55° C. for 3.5 h. After the reaction was completed, the mixture was aged at room temperature for 48 h to obtain a mixed solution;
[0053] (3) The pretreated diatomaceous earth of step (1) was added to water at a mass ratio of 1:1 to the mixed solution, and the mixed solution of step (2) was added, and the mixture was reacted at a constant temperature of 65° C. for 4.5 h. After the reaction was completed, the mixture was aged at room temperature for 22 h to obtain a sustained-release agent.
[0054] Example 2 also provides a method for preparing a compound essential oil having a sleep-inducing effect, as follows:
[0055] (a) weighing each raw material according to the weight ratio, mixing lavender essential oil, rosemary leaf oil, jujube seed essential oil, gardenia essential oil, bergamot oil, and smilax glabra root extract to obtain a mixture A;
[0056] (b) adding the sustained-release agent to water and mixing uniformly to obtain a sustained-release agent solution;
[0057] (c) Adding mixture A to the sustained-release agent solution, stirring at 35° C. for 3.5 h, allowing to stand, filtering, and vacuum drying, then adding Span-20, and homogenizing at 0.05 MPa for 15 min to obtain the compound essential oil with sleep-inducing effect.
[0058] Example 3
[0059] Example 3 provides a compound essential oil with a sleep-inducing effect, which is composed of the following raw materials in the following weight ratios: 10 parts of lavender essential oil, 5 parts of rosemary leaf oil, 5 parts of jujube seed essential oil, 5 parts of gardenia essential oil, 3 parts of bergamot oil, 3 parts of smilax china root extract, 1 part of a sustained-release agent, 2.5 parts of Tween-80, and 20 parts of water.
[0060] The preparation process of the above-mentioned sustained-release agent is as follows:
[0061] (1) adding diatomaceous earth to sodium hydroxide solution at a mass ratio of 1:15, stirring at 75°C for 1.5 hours, filtering, washing, drying, and calcining at 400°C for 2.5 hours to obtain pretreated diatomaceous earth;
[0062] (2) Sodium carbonate was added to a 0.5 mol / L zinc chloride solution at a ratio of 5 g:900 mL, and the mixture was heated at 65° C. for 2.5 h. After the reaction was completed, the mixture was aged at room temperature for 52 h to obtain a mixed solution;
[0063] (3) The pretreated diatomaceous earth described in step (1) is added to water at a mass ratio of 1:4 to the mixed solution, and then the mixed solution of step (2) is added, and the mixture is reacted at a constant temperature of 75° C. for 3.5 hours. After the reaction is completed, the mixture is aged at room temperature for 24 hours to obtain a sustained-release agent.
[0064] Example 3 also provides a method for preparing a compound essential oil having a sleep-inducing effect, which is as follows:
[0065] (a) weighing each raw material according to the weight ratio, mixing lavender essential oil, rosemary leaf oil, jujube seed essential oil, gardenia essential oil, bergamot oil, and smilax glabra root extract to obtain a mixture A;
[0066] (b) adding the sustained-release agent to water and mixing uniformly to obtain a sustained-release agent solution;
[0067] (c) Adding mixture A to the sustained-release agent solution, stirring at 45° C. for 2.5 h, allowing to stand, filtering, and vacuum drying, then adding Tween-80, and homogenizing at 0.15 MPa for 10 min to obtain the compound essential oil with sleep-inducing effect.
[0068] Comparative Example
[0069] Comparative Example 1
[0070] The difference between Comparative Example 1 and Example 1 is that diatomaceous earth is used instead of the sustained-release agent.
[0071] Comparative Example 2
[0072] The difference between Comparative Example 2 and Example 1 is that the extract of the root of the Ampelopsis pilosula was omitted.
[0073] Test example
[0074] Test Example 1
[0075] Transdermal absorption model: Using ex vivo porcine skin as a skin model, 0.5 g of the samples from Examples 1-3 and Comparative Examples 1-2 were added to the donor chamber of a Franz diffusion cell. The receiving chamber was filled with pH 7.4 PBS buffer. Permeation experiments were conducted at 37°C for 72 hours. Every 4 hours, 1 mL of receiving solution was sampled. Fresh receiving solution of the same volume and temperature was immediately added after each sampling to maintain a constant volume and temperature in the receiving chamber.
[0076] I. The cumulative transdermal absorption of jujube seed essential oil in 24 hours was determined by HPLC. The results are shown in Table 1.
[0077] II. The cumulative release percentage of jujube seed essential oil within 72 h was determined by HPLC. The sustained-release performance evaluation results (72 h cumulative release percentage of jujube seed essential oil) are shown in Table 2.
[0078] A=B / W
[0079] B is the content of jujube seed essential oil in the receiving chamber at the sampling time point, and W is the content of jujube seed essential oil in the compound essential oil.
[0080] Table 1
[0081]
[0082]
[0083] Table 2
[0084] Group 72h cumulative release percentage (%) Example 1 86.5 Example 2 85.6 Example 3 85.3 Comparative Example 1 80.9 Comparative Example 2 85.8
[0085] As shown in Tables 1-2, Examples 1-3 exhibited excellent transdermal absorption and sustained-release properties. Compared to Example 1, the transdermal absorption of the compound essential oil obtained in Comparative Example 1, which used diatomaceous earth instead of the sustained-release agent, was reduced. These results demonstrate that the sustained-release agent obtained by the present invention improves the transdermal absorption efficiency of the active ingredients of the compound essential oil.
[0086] The compound essential oil obtained in the present invention has a cumulative release rate of jujube seed essential oil exceeding 85.3% within 72 hours. Compared to Example 1, the compound essential oil obtained in Comparative Example 1, which uses diatomaceous earth instead of a sustained-release agent, exhibits reduced sustained-release performance. This may be due to the present invention first treating the diatomaceous earth with an alkaline solution to increase its internal pore structure, and then using a mixed solution of zinc chloride to perform pillar modification, thereby increasing its specific surface area and stability, further improving its sustained-release performance and extending the aroma retention of the essential oil. Furthermore, modification with zinc chloride can enhance the antibacterial properties of the compound essential oil.
[0087] Test Example 2
[0088] A 10 cm x 10 cm sheet of coated paper was prepared to simulate human skin. The compound essential oils from Examples 1-3 and Comparative Examples 1-2 were added dropwise and gently spread evenly. After 30 seconds, a dry paper towel was placed on the coated paper surface to inspect for any signs of poor absorption, such as stickiness, stringiness, or moisture. The results are shown in Table 3.
[0089] Table 3
[0090] Group Absorbency Example 1 Absorb all Example 2 Absorb all Example 3 Absorb all Comparative Example 1 Absorb all Comparative Example 2 Wet and stringy paper towels
[0091] As shown in Table 3, Examples 1 to 3 exhibited excellent absorption performance. Compared with Example 1, the absorption performance of the compound essential oil obtained in Comparative Example 2, in which the extract of the hornwort root was omitted, was somewhat lower.
[0092] Test Example 3
[0093] A total of 70 male ICR mice aged 6-8 weeks were randomly divided into 7 groups:
[0094] (1) Blank control group: Place a cotton ball soaked in 0.5g of saline in the mouse cage;
[0095] (2) Positive control group: oral administration of Yixinningshen tablets 1.58g powder / kg;
[0096] (3) Example 1 group: A cotton ball soaked with 0.5 g of essential oil was placed in the mouse cage;
[0097] (4) Example 2 group: A cotton ball soaked with 0.5 g of essential oil was placed in the mouse cage;
[0098] (5) Example 3 group: A cotton ball soaked with 0.5 g of essential oil was placed in the mouse cage;
[0099] (6) Comparative Example 1: A cotton ball soaked in 0.5 g of essential oil was placed in the mouse cage;
[0100] (7) Comparative Example 2: Place a cotton ball soaked in 0.5 g of essential oil into the mouse cage;
[0101] The cotton balls were changed twice daily for a total of 7 days. Thirty minutes after the last cotton ball change, mice in each group were intraperitoneally injected with 45 mg / kg of sodium pentobarbital. Loss of the righting reflex (loss of righting for more than 60 seconds) was used as the indicator of animal sleep onset. Sleep latency (the time from the injection of sodium pentobarbital to the loss of the righting reflex) and sleep duration (the time from the loss of the righting reflex to the recovery of the righting reflex) were recorded. The results are shown in Table 4.
[0102] Table 4
[0103] Group Sleep latency (min) Sleep time (min) Blank control group 9.1 14.2 Positive control group 4.8 30.4 Example 1 2.3 35.1 Example 2 2.5 34.6 Example 3 2.5 34.2 Comparative Example 1 3.4 32.7 Comparative Example 2 5.7 29.8
[0104] As shown in Table 4, Examples 1-3 all significantly shortened sleep latency and prolonged sleep time. Compared to Example 1, Comparative Example 1 replaced the sustained-release agent with diatomaceous earth, and Comparative Example 2 omitted the hornwort root extract. The resulting compound essential oil was less effective. Combined with the absorbability test results, the addition of the hornwort root extract can enhance the body's absorption and utilization of the essential oil, further enhancing the sleep-inducing effect and improving sleep quality.
[0105] Test Example 4
[0106] The compound essential oils obtained in Examples 1-3 were placed at 5° C., 25° C., and 35° C. for 15 days, and then observed to see whether precipitation occurred or whether color changed. The results are shown in Table 5.
[0107] Table 5
[0108] Group / Temperature 5℃ 25℃ 35℃ Example 1 No precipitation, no color change No precipitation, no color change No precipitation, no color change Example 2 No precipitation, no color change No precipitation, no color change No precipitation, no color change Example 3 No precipitation, no color change No precipitation, no color change No precipitation, no color change
[0109] As shown in Table 5, the compound essential oil obtained by the present invention has no precipitation and no color change when placed at 5°C, 25°C, and 35°C for 15 days, has a long storage time, and is highly stable.
[0110] Finally, it should be noted that the above embodiments are intended only to illustrate the technical solutions of the present invention and are not intended to limit the same. The basic principles and main features of the present invention have been described above using specific implementation schemes. Modifications or substitutions may be made based on the present invention, but such modifications or substitutions do not detract from the essence of the corresponding technical solutions from the scope of protection claimed by the present invention.
Claims
1. A compound essential oil with sleep-inducing effect, characterized in that: The invention is composed of the following raw materials in the following proportions by weight: 5-10 parts of lavender essential oil, 3-5 parts of rosemary leaf oil, 1-5 parts of jujube seed essential oil, 2-5 parts of gardenia essential oil, 1-3 parts of bergamot oil, 1-3 parts of hornwort root extract, 0.5-1 parts of sustained-release agent, 1-2.5 parts of emulsifier and 10-20 parts of water.
2. The compound essential oil having sleep-inducing efficacy according to claim 1, characterized in that: The preparation process of the sustained-release agent is as follows: (1) adding diatomaceous earth to a sodium hydroxide solution and stirring the solution, filtering, washing, drying, and then calcining the solution to obtain pretreated diatomaceous earth; (2) adding sodium carbonate to a zinc chloride solution for heating reaction, and performing aging treatment at room temperature after the reaction is completed to obtain a mixed solution; (3) adding the diatomaceous earth pretreated in step (1) to water, and then adding the mixed solution in step (2) to carry out a reaction. After the reaction is completed, the mixture is aged at room temperature to obtain a sustained-release agent.
3. The compound essential oil having sleep-inducing efficacy according to claim 2, characterized in that: The mass ratio of the diatomaceous earth to the sodium hydroxide solution in step (1) is 1:(10-15); the concentration of the sodium hydroxide solution is 5-10%; the stirring temperature is 65-75° C., and the stirring time is 1.5-2.5 hours; the calcination temperature is 300-400° C., and the calcination time is 2.5-3.5 hours.
4. The compound essential oil having sleep-inducing efficacy according to claim 2, characterized in that: The dosage ratio of the sodium carbonate and zinc chloride solution in step (2) is (1-5) g: (800-900) mL; the concentration of the zinc chloride solution is 0.1-0.5 mol / L; the temperature of the heating reaction is 55-65° C., and the heating reaction time is 2.5-3.5 h; and the aging treatment time is 48-52 h.
5. The compound essential oil having sleep-inducing efficacy according to claim 2, characterized in that: The mass ratio of the pretreated diatomaceous earth to the mixed solution in step (3) is 1:(1-4); the reaction temperature is 65-75° C., the reaction time is 3.5-4.5 h; and the aging treatment time is 22-24 h.
6. The compound essential oil having sleep-inducing efficacy according to claim 1, characterized in that: The emulsifier is Tween-80 or Span-20.
7. The compound essential oil having sleep-inducing efficacy according to claim 1, characterized in that: The compound essential oil can be used by any one or more of spraying, smearing and massage.
8. The method for preparing the compound essential oil having sleep-aiding efficacy according to any one of claims 1 to 7, wherein: The steps include: (a) weighing each raw material according to the weight ratio, mixing lavender essential oil, rosemary leaf oil, jujube seed essential oil, gardenia essential oil, bergamot oil, and smilax glabra root extract to obtain a mixture A; (b) adding the sustained-release agent to water and mixing uniformly to obtain a sustained-release agent solution; (c) adding mixture A to the sustained-release agent solution and stirring uniformly, allowing to stand, filtering, and vacuum drying, and then adding an emulsifier for homogenization to obtain the compound essential oil with sleep-inducing efficacy.
9. The method for preparing the compound essential oil having sleep-aiding efficacy according to claim 8, wherein: The stirring temperature in step (c) is 35-45° C., and the stirring time is 2.5-3.5 h.
10. The method for preparing the compound essential oil having sleep-inducing efficacy according to claim 8, wherein: The homogenization conditions in step (c) are as follows: pressure of 0.05-0.15 MPa, time of 10-15 min.