Bone deficiency repairing device

Abstract

The invention discloses a bone loss repairing device which comprises a repairing part, the repairing part serves as a metal implant and uses titanium alloy as a main material, extension assemblies are installed on the top wall and the bottom wall of the repairing part, a porous assembly is installed in the repairing part, and a plurality of fixing assemblies are evenly installed on the edge of the outer wall of the repairing part. The outer edge positions of the top wall and the bottom wall of the repairing piece are each provided with a release assembly. The porous assembly comprises outer wall holes, the multiple outer wall holes are evenly formed in the top wall of the repair part, and multiple inner wall holes are evenly formed in the bottom wall of the repair part. According to the bone deficiency repairing device, through the arrangement of the porous assembly and the multi-gradient aperture gradient change, the elastic modulus and the stress shielding effect can be reduced, bone tissue is approached, bone can grow into inner wall holes conveniently, meanwhile, the internal strength of an implant is increased, biocompatibility is good, rejection reaction is reduced, and bone ingrowth is promoted through the porous structure.

Description

Technical Field

[0001] The present invention relates to the technical field of bone repair, in particular to a bone loss repair device. Background Art

[0002] Bone loss repair devices refer to a general term for a class of medical devices or biomaterials used to repair bone defects or losses caused by trauma, infection, tumor resection, congenital malformations or degenerative diseases. They are materials, devices or technology combinations used to fill, repair and reconstruct missing bone tissue. From traditional autologous bone and allogeneic bone, to synthetic ceramics and polymers, to advanced metal implants (especially 3D printing), bioactive materials loaded with growth factors or cells (tissue engineering products), and biomembranes that guide regeneration, all fall into this category.

[0003] Regarding the above-mentioned related technologies, the applicant believes that: some bone repair components currently made of materials, such as titanium alloy, have become the core materials for repairing defects in load-bearing parts due to their high specific strength and good biocompatibility. However, there are certain shortcomings when they are used. When used, the metal elastic modulus is too high, resulting in stress shielding problems.

[0004] To this end, the present invention provides a bone loss repair device to solve the above problems. Summary of the Invention

[0005] In view of the deficiencies in the prior art, the present invention provides a bone loss repair device to solve the above problems.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solutions: a bone loss repair device, comprising a repair component, the repair component being a metal implant using titanium alloy as the main material, the top and bottom walls of the repair component being installed with extension components, the interior of the repair component being installed with a porous component, a plurality of fixing components being evenly installed on the outer edge of the repair component, and release components being installed on the outer edges of the top and bottom walls of the repair component;

[0007] The porous component includes outer wall holes, a plurality of the outer wall holes are evenly arranged on the top wall of the repair component, and a plurality of inner wall holes are evenly arranged on the bottom wall of the repair component, and the plurality of the outer wall holes are connected to the corresponding inner wall holes;

[0008] The porosity of the outer wall pores formed in the dense layer of the outer wall of the repair component is approximately 10%, and the porosity of the outer wall pores formed in the inner wall of the repair component is approximately 70%. The outer wall pores and inner wall pores on the repair component are designed as gradient porous pores, and the pore size gradient of the outer wall pores and inner wall pores changes from 200 μm on the surface to 600 μm in the core.

[0009] The modulus of several outer wall holes is about 80GPa, and the modulus of several inner wall holes is about 3-20GPa. The outer wall holes and inner wall holes on the repair part are designed with a multi-level gradient, which can reduce the elastic modulus and stress shielding effect, approach bone tissue to facilitate bone growth into the inner wall holes, and at the same time increase the internal strength of the implant.

[0010] Through the above technical solution, the setting of the porous component and the gradient design of the pore size of the outer wall holes and the inner wall holes can reduce the elastic modulus and stress shielding effect of the repair part, thereby increasing the internal strength of the repair part and providing the necessary mechanical support during the bone healing process.

[0011] Furthermore, the outer wall of the repair part is evenly sprayed with a hydroxyapatite coating or graphene oxide, which can reduce the immune response, modify the surface of the titanium alloy of the repair part, and improve biocompatibility.

[0012] By means of the above technical solution, the surface of the repair component is modified, thereby improving the biocompatibility of the repair component with bone tissue and surrounding tissues.

[0013] Furthermore, the extension component includes two groups of stress release grooves, which are arranged symmetrically up and down, with four stress release grooves in each group. Each group of stress release grooves is evenly distributed at the four corners of the outer wall of the repair part. Several of the stress release grooves are mainly used to release the stress of the repair part when it is in use. The setting of several of the stress release grooves prevents stress concentration from causing deformation or damage to the internal structure of the repair part.

[0014] Through the above technical solution, when the repair part mechanically supports the bone tissue, there will be a problem of stress concentration when it is subjected to force. By setting stress release grooves at the four corners of the repair part, the repair part can release stress when it is mechanically supported, thereby preventing structural damage inside the repair part.

[0015] Furthermore, a number of extension grooves are evenly provided on the top and bottom walls of the repair component at positions corresponding to the outer wall holes and the inner wall holes, and a number of the extension grooves are provided with connecting grooves. The several connecting grooves located on the top wall of the repair component are connected to the corresponding outer wall holes, and the several connecting grooves located on the bottom wall of the repair component are connected to the corresponding inner wall holes. The provision of the several extension grooves and connecting grooves is used for covering and connecting the growth of bone tissue and surrounding tissue.

[0016] Through the above technical solution, when the extension groove and the connecting groove are provided and connected with the inner wall hole, a surface or groove body is provided, allowing host bone cells to crawl and grow along its surface or pores.

[0017] Furthermore, the fixing assembly includes a fixing part, one end of which is fixedly connected to the outer wall of the repair part, the top wall of the fixing part is provided with a receiving opening, the bottom wall of the fixing part is provided with a through opening corresponding to the position of the receiving opening, and the through opening and the receiving opening are connected.

[0018] Through the above technical solution, the accommodating opening on the fixing piece is communicated with the through opening, and is mainly used for installing the fastener.

[0019] Furthermore, the inner walls of the accommodating opening and the through opening are both installed with fasteners for fixing the repair component, and the fasteners are mainly screwed and fixed to the surrounding bone tissue.

[0020] Through the above technical solution, the fasteners are mainly screwed and fixed to the surrounding bone tissue, so that the repair part can be installed and fixed.

[0021] Furthermore, the release component includes a pH-sensitive hydrogel rod, the front and rear parts of the outer wall of the pH-sensitive hydrogel rod are fixedly connected to the bottom wall of the repair part through a fixing seat, and the pH-sensitive hydrogel rod is mainly used to release antibiotics when tissue infection occurs.

[0022] Through the above technical solution, the pH-sensitive hydrogel stick is mainly used to release antibiotics when tissue infection occurs, thereby reducing the problem of inflammation or rejection reaction of the repair part.

[0023] Furthermore, the top and bottom walls of the repair part are evenly provided with accommodating ring grooves, the inner walls of the two accommodating ring grooves are both pasted with double-sided stickers, the front and rear parts of the outer walls of the two double-sided stickers are both pasted with a number of growth factor microspheres, the left and right sides of the outer walls of the two double-sided stickers are both pasted with a number of bioactive ion balls, and the inner walls of the two accommodating ring grooves are both installed with protective films.

[0024] Through the above technical solution, the protective film is mainly provided to protect the growth factor microspheres and bioactive ion spheres, and the protective film is torn off when the repair part is installed.

[0025] Furthermore, several of the growth factor microspheres and bioactive ion spheres use a PLGA shell with a thickness of approximately 10 μm. The release curves of several of the growth factor microspheres and bioactive ion spheres are a burst release of <20% within 7 days and a sustained release of >70% within 30 days. Several of the growth factor microspheres are mainly used to directly direct stem cell differentiation and angiogenesis, and promote mesenchymal stem cells to differentiate into osteoblasts through time-controlled release of signal molecules, thereby solving the problems of short half-life and burst release failure of traditional growth factors. Several of the bioactive ion spheres are mainly used to regulate bone metabolic balance and antibacterial immune microenvironment through continuous release of metal ions, thereby solving the problems of biological inertness and infection risk of metal materials.

[0026] Through the above technical solution, by setting up growth factor microspheres and bioactive ion spheres, it is possible to stimulate the host's undifferentiated mesenchymal stem cells to differentiate into osteoblasts and regulate bone metabolism balance and antibacterial immune microenvironment.

[0027] Furthermore, a plurality of triangular protrusions are evenly and fixedly mounted on the front and rear walls of the repair component, and the plurality of triangular protrusions are all arranged with a plane facing upward.

[0028] Through the above technical solution, when the repair part is installed, the triangular protrusions hook and fix the bone tissue, thereby assisting in fixing the repair part.

[0029] Beneficial effects

[0030] The present invention provides a bone loss repair device. Compared with the prior art, it has the following advantages:

[0031] (1) The bone loss repair device, through the setting of porous components and the multi-gradient pore size gradient change, can reduce the elastic modulus and stress shielding effect, approach the bone tissue to facilitate bone growth into the inner wall pores, and at the same time increase the internal strength of the implant, making it biocompatible and reducing rejection reactions. The porous structure promotes bone growth.

[0032] (2) The bone loss repair device, through the setting of the fixing component, when installing the titanium alloy repair part, is screwed together with the bone tissue and the surrounding structural tissue through the fasteners, and the triangular protrusions are abutted against the bone tissue, thereby achieving the fixation of the repair part.

[0033] (3) The bone loss repair device, through the setting of the extension component, the extension groove and the connecting groove enable the host bone cells to crawl and grow along its surface or pores, so that the repair part has bone conductivity. At the same time, the stress release groove is set. When the repair part provides necessary mechanical support during the bone healing process, there will be a certain stress concentration. By setting the stress release grooves at the four corners of the repair part, stress concentration can be prevented to avoid the problem of structural damage to the repair part.

[0034] (4) The bone loss repair device, through the setting of the release component, can tear off the protective film to allow it to contact the external bone tissue when using growth factor microspheres and bioactive ion spheres. The growth factor microspheres are mainly used to directly direct stem cell differentiation and angiogenesis through time-controlled release of signal molecules, and promote the differentiation of mesenchymal stem cells into osteoblasts, thereby solving the problems of short half-life and sudden release failure of traditional growth factors. The bioactive ion spheres are mainly used to regulate bone metabolic balance and antibacterial immune microenvironment through continuous release of metal ions, thereby solving the problems of biological inertness and infection risk of metal materials. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1This is a front view of the overall structure of the present invention;

[0036] Figure 2 It is a top view of the external structure of the present invention;

[0037] Figure 3 This is a bottom view of the external structure of the present invention;

[0038] Figure 4 It is a schematic diagram of the right side of the external structure of the present invention;

[0039] Figure 5 is an exploded view of the internal structure of the release assembly of the present invention;

[0040] Figure 6 The present invention Figure 5 A magnified view of the structure at point A;

[0041] Figure 7 It is a schematic diagram of the internal structure of the release assembly of the present invention;

[0042] Figure 8 It is a schematic diagram of the external structure of the repair part of the present invention.

[0043] In the figure, 1. repair part; 2. fixing component; 21. fixing part; 22. fastener; 23. through-hole; 24. accommodating port; 3. extension component; 31. stress relief groove; 32. extension groove; 33. connecting groove; 4. release component; 41. accommodating ring groove; 42. double-sided tape; 43. growth factor microspheres; 44. bioactive ion spheres; 45. protective film; 46. pH-sensitive hydrogel rod; 47. fixing seat; 5. porous component; 51. outer wall hole; 52. inner wall hole; 6. triangular protrusion. DETAILED DESCRIPTION

[0044] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0045] Example 1:

[0046] See also Figure 1-8 A bone loss repair device includes a repair part 1. The repair part 1 is a metal implant made of titanium alloy as the main material. The top and bottom walls of the repair part 1 are both installed with extension components 3. A porous component 5 is installed inside the repair part 1. A plurality of fixing components 2 are evenly installed on the edge of the outer wall of the repair part 1. Release components 4 are installed on the outer edges of the top and bottom walls of the repair part 1.

[0047] The porous component 5 includes outer wall holes 51, and a plurality of outer wall holes 51 are evenly opened on the top wall of the repair component 1. A plurality of inner wall holes 52 are evenly opened on the bottom wall of the repair component 1, and the plurality of outer wall holes 51 are connected to the corresponding inner wall holes 52;

[0048] The outer wall pores 51 formed in the dense layer of the outer wall of the repair component 1 have a porosity of approximately 10%, and the outer wall pores 51 formed in the inner wall of the repair component 1 have a porosity of approximately 70%. The outer wall pores 51 and the inner wall pores 52 on the repair component 1 have a gradient porous design, with the pore size gradient varying from 200 μm on the surface to 600 μm in the core.

[0049] The modulus of the plurality of outer wall holes 51 is approximately 80 GPa, and the modulus of the plurality of inner wall holes 52 is approximately 3-20 GPa. The outer wall holes 51 and the inner wall holes 52 on the repair component 1 are designed with a multi-level gradient, which can reduce the elastic modulus and stress shielding effect, close to the bone tissue to facilitate bone growth into the inner wall holes 52, and at the same time increase the internal strength of the implant;

[0050] The outer wall of the repair part 1 is evenly sprayed with a hydroxyapatite coating or graphene oxide, which can reduce the immune response, modify the surface of the titanium alloy of the repair part 1, and improve biocompatibility;

[0051] In the embodiment of the present invention, the purpose of this arrangement is that the porous component 5 can reduce the elastic modulus of the repair component 1, thereby avoiding the problem of stress shielding effect. The design of the gradient change in the pore size of the outer wall pores 51 and the inner wall pores 52 facilitates the connection and growth of bone tissue into the outer wall pores 51 and the inner wall pores 52, thereby increasing the overall strength of the repair component 1.

[0052] When the hydroxyapatite coating or graphene oxide is evenly sprayed on the surface of the repair part 1, the surface of the repair part 1 can be modified, thereby improving the biocompatibility and reducing the probability of inflammation or rejection reaction.

[0053] Example 2:

[0054] See also Figure 1-8, this embodiment provides a technical solution based on the first embodiment: the extension component 3 includes two groups of stress relief grooves 31, the two groups of stress relief grooves 31 are symmetrically arranged in an upper and lower manner, each group of stress relief grooves 31 has four stress relief grooves, and each group of stress relief grooves 31 is evenly distributed at the four corners of the outer wall of the repair component 1. The stress relief grooves 31 are mainly used for stress relief of the repair component 1 when in use. The provision of the stress relief grooves 31 prevents stress concentration from causing deformation or damage to the internal structure of the repair component 1. The top wall and the bottom wall of the repair component 1 are evenly provided with a plurality of extension grooves 32 at positions corresponding to the outer wall holes 51 and the inner wall holes 52. The plurality of extension grooves 32 are all provided with connecting grooves 33. The plurality of connecting grooves 33 located on the top wall of the repair component 1 are all connected to the corresponding outer wall holes 51, and the plurality of connecting grooves 33 located on the bottom wall of the repair component 1 are all connected to the corresponding inner wall holes 52. The provision of the plurality of extension grooves 32 and the connecting grooves 33 are both used for covering and connecting growth of bone tissue and surrounding tissues;

[0055] In the embodiment of the present invention, the purpose of this arrangement is that the extension component 3 is connected to the inner wall hole 52 through the designed extension groove 32 and the connecting groove 33, and is mainly used to provide a creeping growth guide area for the growth of bone tissue and surrounding tissue. When the repair component 1 is used for mechanical support of bone tissue, stress concentration will occur, and the stress is released and relieved through the stress release groove 31 to prevent the repair component 1 from structural changes or damage.

[0056] Example 3:

[0057] See also Figure 1-8 This embodiment provides a technical solution based on the first embodiment: the fixing assembly 2 includes a fixing member 21, one end of which is fixedly connected to the outer wall of the repair member 1, the top wall of the fixing member 21 is provided with a receiving opening 24, and the bottom wall of the fixing member 21 is provided with a through opening 23 at a position corresponding to the receiving opening 24, the through opening 23 and the receiving opening 24 are connected, and the inner walls of the receiving opening 24 and the through opening 23 are both installed with fasteners 22 for fixing the repair member 1, and the fasteners 22 are mainly screwed and fixed to the surrounding bone tissue;

[0058] In the embodiment of the present invention, the purpose of this arrangement is that the fixing assembly 2 is arranged so that the fastener 22 passes through the accommodating opening 24 and the through opening 23 and is screwed and fixed to the bone tissue around the repair part 1, thereby stabilizing the repair part 1.

[0059] Example 4:

[0060] See also Figure 1-8This embodiment provides a technical solution based on the first embodiment: the release component 4 includes a pH-sensitive hydrogel rod 46. The front and rear outer walls of the pH-sensitive hydrogel rod 46 are fixedly connected to the bottom wall of the repair component 1 through a fixing seat 47. The pH-sensitive hydrogel rod 46 is mainly used to release antibiotics when tissue infection occurs. The top and bottom walls of the repair component 1 are evenly provided with accommodating ring grooves 41. The inner walls of the two accommodating ring grooves 41 are both pasted with double-sided stickers 42. The front and rear outer walls of the two double-sided stickers 42 are both pasted with a number of growth factor microspheres 43. The left and right outer walls of the two double-sided stickers 42 are both pasted with a number of bioactive ion balls 44. The inner walls of the two accommodating ring grooves 41 are both installed with protective films 45. The plurality of growth factor microspheres 43 and bioactive ion spheres 44 all use a PLGA shell with a thickness of approximately 10 μm. The release curves of the plurality of growth factor microspheres 43 and bioactive ion spheres 44 are a burst release of <20% within 7 days and a sustained release of >70% within 30 days. The plurality of growth factor microspheres 43 are primarily used to directly direct stem cell differentiation and angiogenesis and promote the differentiation of mesenchymal stem cells into osteoblasts through time-controlled release of signal molecules, thereby resolving the problems of short half-life and burst release failure of traditional growth factors. The plurality of bioactive ion spheres 44 are primarily used to regulate bone metabolic balance and antibacterial immune microenvironment through sustained release of metal ions, thereby resolving the problems of biological inertness and infection risk of metal materials.

[0061] A plurality of triangular protrusions 6 are evenly fixedly mounted on the front and rear walls of the repair component 1, and the plurality of triangular protrusions 6 are arranged with the plane facing upwards;

[0062] In the embodiment of the present invention, the purpose of this setting is that the setting of the release component 4, mainly the setting of the pH-sensitive hydrogel rod 46, can make the repair part 1 have good biocompatibility and reduce the problems of inflammation and rejection reaction. The setting of the growth factor microspheres 43 and the bioactive ion spheres 44 promotes the differentiation of mesenchymal stem cells into osteoblasts and regulates the bone metabolism balance and antibacterial immune microenvironment.

[0063] Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0064] Working principle of this device: The repair component 1 is made of titanium alloy and serves as the main material for repairing bone loss. The fixing assembly 2 is provided to install the repair component 1 at the location of the bone loss. The movable fastener 22 passes through the receiving opening 24 and the through opening 23 on the fixing component 21 and is screwed and fixed to the surrounding bone tissue. The triangular protrusion 6 is inserted into the surrounding tissue to assist in fixing the repair component 1, thereby installing and fixing the repair component 1.

[0065] The provision of the extension component 3 allows stress in the repair component 1 to be released, while guiding the bone tissue to cover and grow. The provision of the stress relief groove 31 is mainly used to release stress in the repair component 1 when in use, preventing stress concentration from causing internal structural changes or structural damage to the repair component 1 during use. The provided extension groove 32 and the connecting groove 33 are connected to the inner wall hole 52. When bone tissue or surrounding tissue grows, they can pass through the inner wall hole 52, the extension groove 32 and the connecting groove 33 and then connect with each other, so that the bone tissue growth and connection have connection and support strength.

[0066] The setting of the release component 4 is mainly used to release antibiotics when tissue infection occurs through the pH-sensitive hydrogel rod 46, thereby inhibiting the problem of tissue infection and allowing the bone tissue and surrounding tissues to grow normally. When installing the repair part 1, the protective film 45 is torn off from the surface of the receiving ring groove 41 on the repair part 1, and the growth factor microspheres 43 and bioactive ion balls 44 attached to the double-sided sticker 42 in the receiving ring groove 41 are exposed to the bone tissue and surrounding tissues. The growth factor microspheres 43 are mainly used to directly direct stem cell differentiation and angiogenesis and promote mesenchymal stem cells to differentiate into osteoblasts through time-controlled release of signal molecules, thereby solving the problems of short half-life and sudden release failure of traditional growth factors. The bioactive ion balls 44 are mainly used to regulate bone metabolic balance and antibacterial immune microenvironment through continuous release of metal ions, thereby solving the problems of biological inertness and infection risk of metal materials;

[0067] The setting of the porous component 5 can reduce the elastic modulus and stress shielding effect, and is close to the bone tissue to facilitate bone growth into the inner wall hole 52. At the same time, the internal strength of the implant is increased. The outer wall of the repair part 1 is evenly sprayed with hydroxyapatite coating or graphene oxide, which can reduce the immune response to surface modification of the titanium alloy of the repair part 1 and improve biocompatibility. Under the multi-level gradient design of the outer wall holes 51 and the inner wall holes 52 opened on the outer wall and inner wall of the repair part 1, the elastic modulus and stress shielding effect can be reduced.

[0068] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0069] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A bone loss repair device, comprising a repair component (1), characterized in that: The repair part (1) is a metal implant made of titanium alloy as a main material, the top wall and the bottom wall of the repair part (1) are both installed with extension components (3), the interior of the repair part (1) is installed with a porous component (5), the outer edge of the repair part (1) is evenly installed with a plurality of fixing components (2), and the outer edges of the top wall and the bottom wall of the repair part (1) are both installed with release components (4); The porous component (5) includes outer wall holes (51), and a plurality of the outer wall holes (51) are evenly arranged on the top wall of the repair component (1). The bottom wall of the repair component (1) is evenly provided with a plurality of inner wall holes (52), and the plurality of the outer wall holes (51) are all connected to the corresponding inner wall holes (52); The porosity of the outer wall pores (51) formed on the dense layer of the outer wall of the repair component (1) is about 10%, and the porosity of the outer wall pores (51) formed on the inner wall of the repair component (1) is about 70%. The plurality of outer wall pores (51) and inner wall pores (52) on the repair component (1) are designed as gradient multi-pores, and the pore size gradient of the outer wall pores (51) and the inner wall pores (52) is 200 μm on the surface → 600 μm in the core; The modulus of the plurality of outer wall holes (51) is about 80 GPa, and the modulus of the plurality of inner wall holes (52) is about 3-20 GPa. The outer wall holes (51) and the inner wall holes (52) on the repair component (1) can reduce the elastic modulus and stress shielding effect through a multi-level gradient design, and are close to bone tissue to facilitate bone growth into the inner wall holes (52), while increasing the internal strength of the implant.

2. The bone loss repair device according to claim 1, characterized in that: The outer wall of the repair part (1) is evenly sprayed with a hydroxyapatite coating or graphene oxide, which can reduce immune response, modify the surface of the titanium alloy of the repair part (1), and improve biocompatibility.

3. The bone loss repair device according to claim 1, characterized in that: The extension component (3) includes two groups of stress release grooves (31), which are symmetrically arranged in an upper and lower direction. Each group of stress release grooves (31) has four stress release grooves, and each group of stress release grooves (31) is evenly distributed at the four corners of the outer wall of the repair part (1). Several of the stress release grooves (31) are mainly used for stress release of the repair part (1) when it is in use. The arrangement of the several stress release grooves (31) prevents stress concentration from causing deformation or damage to the internal structure of the repair part (1).

4. The bone loss repair device according to claim 1, characterized in that: The top wall and bottom wall of the repair component (1) are evenly provided with a plurality of extension grooves (32) at positions corresponding to the outer wall holes (51) and the inner wall holes (52). A plurality of the extension grooves (32) are provided with connecting grooves (33). The connecting grooves (33) located on the top wall of the repair component (1) are connected to the corresponding outer wall holes (51), and the connecting grooves (33) located on the bottom wall of the repair component (1) are connected to the corresponding inner wall holes (52). The arrangement of the plurality of extension grooves (32) and connecting grooves (33) is used for covering and connecting the growth of bone tissue and surrounding tissue.

5. The bone loss repair device according to claim 1, characterized in that: The fixing assembly (2) comprises a fixing member (21), one end of the fixing member (21) is fixedly connected to the outer wall of the repair member (1), a receiving opening (24) is provided on the top wall of the fixing member (21), a through opening (23) is provided on the bottom wall of the fixing member (21) at a position corresponding to the receiving opening (24), and the through opening (23) and the receiving opening (24) are in communication.

6. The bone loss repair device according to claim 5, characterized in that: The inner walls of the accommodating opening (24) and the through opening (23) are both installed with fasteners (22) for fixing the repair component (1), and the fasteners (22) are mainly screwed and fixed to the surrounding bone tissue.

7. The bone loss repair device according to claim 1, characterized in that: The release assembly (4) includes a pH-sensitive hydrogel rod (46), the front and rear outer walls of which are fixedly connected to the bottom wall of the repair component (1) via a fixing seat (47). The pH-sensitive hydrogel rod (46) is mainly used to release antibiotics when tissue infection occurs.

8. The bone loss repair device according to claim 1, characterized in that: The top and bottom walls of the repair component (1) are evenly provided with accommodating ring grooves (41), the inner walls of the two accommodating ring grooves (41) are both pasted with double-sided stickers (42), the front and rear parts of the outer walls of the two double-sided stickers (42) are both pasted with a number of growth factor microspheres (43), the left and right sides of the outer walls of the two double-sided stickers (42) are both pasted with a number of bioactive ion balls (44), and the inner walls of the two accommodating ring grooves (41) are both installed with protective films (45).

9. The bone loss repair device according to claim 8, characterized in that: Several of the growth factor microspheres (43) and bioactive ion spheres (44) use a PLGA shell with a thickness of about 10 μm. The release curves of several of the growth factor microspheres (43) and bioactive ion spheres (44) are a burst release of <20% within 7 days and a sustained release of >70% within 30 days. Several of the growth factor microspheres (43) are mainly used to directly direct stem cell differentiation and angiogenesis and promote mesenchymal stem cells to differentiate into osteoblasts through time-controlled release of signal molecules, thereby solving the problems of short half-life and burst release failure of traditional growth factors. Several of the bioactive ion spheres (44) are mainly used to regulate bone metabolic balance and antibacterial immune microenvironment through continuous release of metal ions, thereby solving the problems of biological inertness and infection risk of metal materials.

10. The bone loss repair device according to claim 1, characterized in that: A plurality of triangular protrusions (6) are evenly and fixedly mounted on the front and rear walls of the repair component (1), and the plurality of triangular protrusions (6) are all arranged with the plane facing upward.

Images