Composition for reducing blood sugar, blood pressure and uric acid as well as preparation method and application of composition

Through the hot pot soup ingredients of specific traditional Chinese medicine ingredients compositions, the problem that existing hot pot soup ingredients cannot lower blood sugar, blood pressure and uric acid at the same time is solved, and the significant effect of lowering sugar, blood pressure and uric acid is achieved, which is suitable for conditioning of different syndromes.

CN120478542APending Publication Date: 2025-08-15ZHEJIANG JINSHANMEI BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202510689863.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-27
Publication Date
2025-08-15

AI Technical Summary

Technical Problem

The existing hot pot soup ingredients cannot effectively reduce blood sugar, blood pressure and uric acid levels at the same time, and some of the effects need to be improved.

Method used

A composition composed of Chinese medicine ingredients such as corn squid, white squid root, coix seed, etc. is used to prepare extract by adding water to decoct and ethanol extraction, and is used to prepare tea products, food, health products or seasonings.

Benefits of technology

It significantly reduces blood sugar, blood pressure and uric acid levels, is suitable for conditioning different syndromes, and has the effects of strengthening the spleen and replenishing qi, nourishing the liver and kidneys, promoting blood circulation and removing blood stasis.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention relates to the technical field of foods or medicines, in particular to a composition for reducing blood sugar, blood pressure and uric acid as well as a preparation method and application of the composition. The composition comprises the following components: corn stigma, lalang grass rhizome, semen coicis, rhizoma phragmitis, brassica juncea, pericarpium citri reticulatae, purslane, ginseng, radix puerariae, folium mori, smoked plum, astragalus membranaceus, codonopsis pilosula, radix ophiopogonis, fructus forsythiae leaves, radix rehmanniae recen, scutellaria baicalensis leaves, prepared rehmannia roots, sea-buckthorn, radix angelicae, rosemary, liquorice, lily, honeysuckle, folium cortex eucommiae, radix polygonati officinalis, Chinese yam, rhizoma polygonati, cistanche, panax notoginseng leaves, dogwood, dandelion, sophora flower bud, purple perilla and semen cassiae. , gastrodia elata and selfheal. The beverage has the advantages of better effects of reducing blood sugar, blood pressure and uric acid.
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Description

Technical Field

[0001] The present invention relates to the technical field of food or medicine, and in particular to a composition for lowering blood sugar, blood pressure and uric acid, and a preparation method and application thereof. Background Art

[0002] Hot pot broth refers to the seasoning used when cooking hot pot ingredients. It's typically a thick soup made from a variety of spices and ingredients, its unique flavor providing the hot pot with a rich taste and flavor. Its primary function is to provide the base seasoning for hot pot cooking, enhancing its flavor. Hot pot broth typically includes spices such as Sichuan peppercorns, dried chili peppers, onions, ginger, and garlic, as well as animal bones such as chicken, pork, and beef bones, and other meat ingredients. The high purine, salt, fat, and sugar content in hot pot broth can affect blood sugar, blood pressure, and uric acid levels.

[0003] Common high-purine ingredients in hot pot include seafood, red meat, and animal offal. These foods produce a large amount of uric acid during metabolism. If hot pot contains a large amount of these ingredients, consuming them may cause a temporary increase in uric acid levels in the blood. In healthy people, the body is usually able to excrete excess uric acid through the kidneys to maintain normal levels. However, in patients with hyperuricemia or gout, the kidneys' ability to excrete uric acid may be limited, and excessive uric acid accumulation may lead to gout attacks.

[0004] In addition to the purine content of the ingredients themselves, the high salt and high fat content of hot pot can also affect uric acid levels. High-salt foods can cause water retention, impairing uric acid excretion. High-fat foods can also burden the kidneys, hindering uric acid excretion. Even healthy people should consume hot pot in moderation and avoid excessive intake of high-purine, high-salt, and high-fat foods.

[0005] Therefore, there is an urgent need to develop a hot pot soup base that can simultaneously lower the body's blood sugar, blood pressure and uric acid content and maintain them at a healthy level.

[0006] Chinese patent publication number CN108095022A discloses a halal compound seasoning for lowering blood sugar, salt, and lipids, comprising pepper extract, ginger extract, garlic, kelp extract, vegetable juice, animal bone meal, yeast extract, persimmon leaf extract, and additives. The compound seasoning not only has a flavoring effect, but also, the components in the seasoning work synergistically to achieve the effects of lowering blood sugar, salt, and lipids, and has an improving effect on hyperglycemia, hypertension, and hyperlipidemia.

[0007] Chinese patent publication number CN106901303A discloses a hot pot seasoning and its production method, the hot pot seasoning is made of the following raw materials in parts by weight: 80-100 parts of rapeseed oil, 0.5-2 parts of ginger, 1-2 parts of garlic, 1-3 parts of green onion, 2-5 parts of Pixian bean paste, 6-8 parts of dried chili peppers, 0.5-2 parts of star anise, 0.1-1 parts of galangal, 0.1 parts of white button. The hot pot seasoning contains 1-2 parts of iodized seaweed salt, 0.1-1 parts of rock sugar, 1-2 parts of white sesame seeds, 1-3 parts of fermented glutinous rice, and 1-5 parts of cooking wine. The hot pot seasoning has a bright red soup color, a refreshing and smooth taste, and has the effects of dispelling cold, stimulating appetite, and removing fat and lowering blood pressure.

[0008] However, the hot pot seasonings in the prior art cannot achieve the effects of lowering blood sugar, lowering blood pressure and lowering uric acid at the same time, and the effects of one or both of these aspects need to be further improved.

[0009] Therefore, it is very necessary to develop a composition for lowering blood sugar, blood pressure and uric acid that can solve the above technical problems, as well as a preparation method and application thereof. Summary of the Invention

[0010] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a composition with good blood sugar, blood pressure and uric acid lowering effects, as well as a preparation method and application thereof.

[0011] The present invention is achieved through the following technical solutions: The first aspect of the present invention provides a composition for lowering blood sugar, blood pressure and uric acid, which comprises the following components in parts by weight: 5-12 parts of corn silk, 10-30 parts of Imperata root, 10-20 parts of coix seed, 10-15 parts of reed root, 10-20 parts of yellow mustard seed, 10-15 parts of tangerine peel, 10-15 parts of purslane, 10-25 parts of ginseng, 10-20 parts of kudzu root, 5-10 parts of mulberry leaf, 5-10 parts of black plum, 25-35 parts of astragalus, 5-15 parts of codonopsis, 5-10 parts of ophiopogon, 12-18 parts of forsythia leaf, 12-15 parts of rehmannia root, 12-1 8 parts, 6-15 parts of Scutellaria baicalensis leaves, 6-15 parts of Rehmannia glutinosa, 6-15 parts of Hippophae rhamnoides, 10-20 parts of Angelica dahurica, 5-10 parts of Rosemary, 2-8 parts of Liquorice, 10-15 parts of Lilium, 20-30 parts of Honeysuckle, 8-20 parts of Eucommia ulmoides leaves, 10-20 parts of Polygonatum odoratum, 10-20 parts of Chinese Yam, 5-15 parts of Polygonatum sibiricum, 6-12 parts of Cistanche deserticola, 8-15 parts of Panax notoginseng leaves, 20-30 parts of Cornus officinalis, 6-12 parts of Taraxacum, 5-10 parts of Sophora japonica seeds, 5-10 parts of Perilla frutescens, 6-12 parts of Cassia seed, 6-12 parts of Gastrodia elata and 5-10 parts of Prunella vulgaris.

[0012] The syndrome of excessive heat damaging body fluids is primarily characterized by thirst, polydipsia, frequent hunger, dry skin, irritability, and hard stools. It is often seen in the early stages of diabetes, with marked increases in fasting and postprandial blood sugar. This syndrome, caused by yin deficiency and dryness, depletes lung and stomach fluids, leading to both upper and middle symptoms of indigestion and is associated with insulin resistance and hyperglycemic metabolic disorders.

[0013] Qi and Yin deficiency syndrome is characterized by fatigue, shortness of breath, laziness to speak, dry throat and mouth, and weight loss. This syndrome is caused by the long-term involvement of Yin deficiency in the Qi component, which leads to a decline in the spleen and stomach's transport and transformation functions, insufficient Qi and blood production, and is associated with a progressive decline in pancreatic beta-cell function.

[0014] Damp-heat accumulation syndrome is common in obese patients with type 2 diabetes, characterized by obesity, dry mouth and aversion to water, short, yellow urine, loose stools, and a greasy yellow tongue coating. This syndrome is caused by damp-heat stagnation in the middle jiao, leading to dysfunction of the spleen and stomach, and accumulation of phlegm and turbidity in the meridians. It is closely associated with intestinal dysbiosis and lipid metabolism disorders.

[0015] In the soup composition of the present invention, mulberry leaves, forsythia leaves, scutellaria leaves, raw rehmannia root, black plum, ophiopogon, imperata root, and yam can be used to improve the syndrome of excessive heat and damage to body fluid; ginseng, kudzu root, mulberry leaves, black plum, astragalus, codonopsis, raw rehmannia root, and yam can be used to improve the syndrome of deficiency of both qi and yin; scutellaria leaves, kudzu root, mulberry leaves, coix seed, forsythia leaves, and black plum can be used to improve the syndrome of accumulation of damp heat. Therefore, the soup composition of the present invention can be applied to lower blood sugar in different syndromes, and has a significant blood sugar lowering effect.

[0016] As an embodiment of the present invention, the composition further comprises spices. Preferably, the spices include at least one of angelica, turmeric, tsaoko, longan, pepper, fructus amomi, cyperus rotundus, cloves, cumin and bay leaves.

[0017] As an embodiment of the present invention, the mass ratio of Imperata cylindrica root, Ophiopogon japonicus and Forsythia suspensa leaf is 3.5-4:1:2-3.

[0018] The second aspect of the present invention provides a method for preparing a composition, comprising the following components: (1) boiling each component with water, filtering, and obtaining a filter residue and a filtrate 1; (2) Extract the filter residue with ethanol solution and filter to obtain filtrate 2; (3) Mix filtrate 1 and filtrate 2, concentrate them into an extract, and dry them to obtain the product.

[0019] As an embodiment of the present invention, in step (1), each component is dried and crushed before being boiled in water.

[0020] Preferably, the pulverization is pulverizing into fine powder.

[0021] As an embodiment of the present invention, in step (1), the number of times of decocting with water is 1-3 times, the amount of water added is 6-10 times the amount, and the filtrate is filtered and combined to obtain filtrate 1.

[0022] As an embodiment of the present invention, the volume concentration of the ethanol solution in step (2) is 70-90%, the extraction temperature is 30-40° C., and the extraction time is 1-2 h.

[0023] A third aspect of the present invention provides a use of the above-mentioned composition or the composition prepared by the above-mentioned preparation method in the preparation of a product for lowering blood sugar, and / or blood pressure, and / or uric acid.

[0024] Preferably, the product is a tea product, food, health product, medicine or food additive.

[0025] More preferably, the food additive is a seasoning.

[0026] More preferably, the seasoning is hot pot soup.

[0027] The beneficial effects of the present invention are: Blood sugar reduction: In the soup composition of the present invention, Polygonatum sibiricum is sweet and neutral in nature, can strengthen the spleen and replenish qi, nourish kidney essence, and strengthen the soil and consolidate the essence; Chinese yam is sweet and neutral in nature, can nourish the spleen and replenish qi; Coix seed is sweet and light in taste, cool in nature, can strengthen the spleen and eliminate dampness; Lily is sweet and slightly cold in nature, can nourish yin and calm the mind; Corn silk is sweet and light in taste, neutral in nature, can promote diuresis and eliminate dampness; Imperata root is sweet and cold in nature, can clear away heat and promote diuresis; Pueraria root is sweet and spicy in taste, cool in nature, can promote body fluid and quench thirst; Sea buckthorn is sour and sweet in taste, slightly warm in nature, all of which can help digestion and eliminate accumulation; Mulberry leaf is sweet, bitter and cold in nature, can suppress liver yang, clear the liver and improve eyesight; Panax notoginseng is sweet and cool in nature, can clear away heat and cool blood, promote blood circulation and relieve pain, and stop bleeding. The combination of the above medicines can both nourish and eliminate, and harmonize the liver, spleen and kidney. It can nourish kidney yin, nourish yin and increase fluid, replenish qi and nourish yin, replenish qi and clear away heat, nourish yin and assist yang, warm and nourish the spleen and kidney, dispel cold and regulate the middle, activate blood circulation and remove blood stasis, clear away heat accumulation, clear away heat and detoxify, clear away heat and remove dampness, strengthen the spleen and replenish qi, promote body fluid and quench thirst, eliminate dampness and awaken the spleen to treat the root cause.

[0028] Blood pressure lowering: The soup composition of the present invention uses corn silk, coix seed, tangerine peel, ginseng, kudzu root, astragalus, codonopsis, ophiopogon, forsythia leaf, rosemary, licorice, angelica, eucommia leaf, polygonatum, cistanche, panax notoginseng leaf, cornus officinalis, dandelion, cassia seed, gastrodia elata and selfheal to coordinate the liver, spleen and kidney, strengthen the body's resistance and eliminate evil, nourish the liver and kidney, nourish yin and replenish essence, calm the liver and suppress yang, nourish yin and support yang, resolve phlegm and dampness, strengthen the spleen and stomach, promote blood circulation and remove stasis, regulate qi and relieve pain, soothe the liver and regulate qi, calm the liver and extinguish wind, clear away heat and resolve phlegm, and support yang and benefit yin to treat the root cause. It can be used to prevent high blood pressure and regulate blood pressure.

[0029] Lowering uric acid: The soup composition of the present invention uses corn silk, Imperata root, Coix seed, Phragmites australis, white mustard seed, purslane, Pueraria root, mulberry leaf, black plum, Astragalus, Codonopsis pilosula, Forsythia leaf, Rehmannia root, Rehmannia root, Angelica dahurica, Liquorice, Lilium, Honeysuckle, Angelica sinensis, Eucommia leaf, Chinese yam, sunflower plate, Cistanche deserticola, Panax notoginseng leaf, turmeric, old loofah, Sophora japonica seed and Perilla frutescens to harmonize the liver, spleen and kidney, nourish the liver and kidney, invigorate blood and promote blood circulation, clear away heat and dispel wind, dredge the meridians and promote dampness, clear away heat and promote dampness, dredge the meridians and relieve pain, dispel wind and relieve pain, clear heat and promote blood circulation, strengthen the spleen and kidney, dispel wind and relieve numbness, dispel wind and dissipate cold, eliminate numbness and relieve pain, relax muscles and activate meridians, and can be used to prevent elevated uric acid and regulate uric acid levels.

[0030] The present invention further optimizes the dosage ratio of Imperata cylindrica root, Ophiopogon japonicus and Forsythia suspensa leaves, thereby improving the blood sugar lowering, uric acid lowering and blood pressure lowering effects. DETAILED DESCRIPTION

[0031] The present invention will be further described below with reference to specific embodiments, and the advantages and features of the present invention will become clearer as the description proceeds. However, these embodiments are merely exemplary and do not constitute any limitation to the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the technical solutions of the present invention may be modified or replaced without departing from the spirit and scope of the present invention, and such modifications and replacements fall within the scope of protection of the present invention.

[0032] Example 1 A composition for lowering blood sugar, blood pressure and uric acid, comprising the following components by weight: 5 parts of corn silk, 10 parts of Imperata root, 10 parts of coix seed, 10 parts of reed root, 10 parts of yellow mustard seed, 10 parts of dried tangerine peel, 10 parts of purslane, 10 parts of ginseng, 10 parts of kudzu root, 5 parts of mulberry leaf, 5 parts of black plum, 25 parts of astragalus, 5 parts of codonopsis, 5 parts of ophiopogon, 12 parts of forsythia leaf, and raw rehmannia. 12 parts of Radix Scutellariae, 6 parts of Radix Rehmanniae Preparata, 6 parts of Hippophae Rhamnoides, 10 parts of the Radix Angelicae Dahuricae, 5 parts of Rosmarinus Officinalis, 2 parts of Radix Glycyrrhizae, 10 parts of Lilium, 20 parts of Flos Lonicerae, 8 parts of Folium Eucommiae, 10 parts of Polygonatum odoratum, 10 parts of Rhizoma Dioscoreae, 5 parts of Polygonatum sibiricum, 6 parts of Herba Cistanches, 8 parts of Folium Notoginseng, 20 parts of Fructus Corni, 6 parts of Herba Taraxaci, 5 parts of Flos Sophorae, 5 parts of Perilla Fructus, 6 parts of Semen Cassiae, 6 parts of Rhizoma Gastrodiae and 5 parts of Spica Prunellae.

[0033] The preparation method of the composition comprises the following steps: (1) After drying, the components were crushed into fine powders, mixed, and decocted three times with 6 times the amount of water. The mixture was filtered and combined to obtain the residue and filtrate 1 respectively. (2) Extract the filter residue with 70% ethanol solution at 30°C for 1 h, and filter to obtain filtrate 2; (3) Mix filtrate 1 and filtrate 2, concentrate them into an extract, and dry them to obtain the product.

[0034] Example 2 A composition for lowering blood sugar, blood pressure and uric acid, comprising the following components by weight: 12 parts of corn silk, 30 parts of Imperata root, 20 parts of coix seed, 15 parts of reed root, 20 parts of yellow mustard seed, 15 parts of dried tangerine peel, 15 parts of purslane, 25 parts of ginseng, 20 parts of kudzu root, 10 parts of mulberry leaf, 10 parts of black plum, 35 parts of astragalus, 15 parts of codonopsis, 10 parts of ophiopogon, 18 parts of forsythia leaf, 18 parts of raw rehmannia root, 15 parts of Scutellariae Folium, 15 parts of Rehmannia glutinosa, 15 parts of Hippophae Rhamnoides, 20 parts of the Angelicae Dahuricae, 10 parts of Rosmarinus Officinalis, 8 parts of Radix Glycyrrhizae, 15 parts of Lilium, 30 parts of Flos Lonicerae, 20 parts of Folium Eucommiae, 20 parts of Polygonatum odoratum, 20 parts of Rhizoma Dioscoreae, 15 parts of Polygonatum Sibiricum, 12 parts of Herba Cistanches, 15 parts of Folium Notoginseng, 30 parts of Fructus Corni, 12 parts of Herba Taraxaci, 10 parts of Flos Sophorae, 10 parts of Perilla Fructus, 12 parts of Semen Cassiae, 12 parts of Rhizoma Gastrodiae and 10 parts of Spica Prunellae.

[0035] The preparation method of the composition comprises the following steps: (1) After drying, the components were crushed into fine powders, mixed, and boiled once with 10 times the amount of water. The mixture was filtered to obtain a residue and filtrate 1. (2) The filter residue was extracted with 90% ethanol solution at 40°C for 2 h, and filtered to obtain filtrate 2; (3) Mix filtrate 1 and filtrate 2, concentrate them into an extract, and dry them to obtain the product.

[0036] Example 3 A composition for lowering blood sugar, blood pressure and uric acid, comprising the following components by weight: 8 parts of corn silk, 20 parts of Imperata root, 15 parts of coix seed, 12 parts of reed root, 15 parts of yellow mustard seed, 12 parts of dried tangerine peel, 12 parts of purslane, 20 parts of ginseng, 15 parts of kudzu root, 7 parts of mulberry leaf, 7 parts of black plum, 30 parts of astragalus, 10 parts of codonopsis, 7 parts of ophiopogon, 15 parts of forsythia leaf, 15 parts of raw rehmannia root, 15 parts of ginseng root, 10 parts of codonopsis root, 10 parts of ophiopogon, 15 parts of forsythia leaf, 15 parts of raw rehmannia root, 15 parts of ginseng root, 10 parts of 1 part, 10 parts of Radix Scutellariae, 10 parts of Radix Rehmanniae Preparata, 10 parts of Hippophae Rhamnoides, 15 parts of the Radix Angelicae Dahuricae, 8 parts of Rosmarinus Officinalis, 5 parts of Radix Glycyrrhizae, 12 parts of Bulbus Lilii, 25 parts of Flos Lonicerae, 14 parts of Folium Eucommiae, 15 parts of Polygonatum odoratum, 15 parts of Rhizoma Dioscoreae, 10 parts of Rhizoma Polygonati, 9 parts of Herba Cistanches, 11 parts of Folium Notoginseng, 25 parts of Fructus Corni, 9 parts of Herba Taraxaci, 8 parts of Flos Sophorae, 8 parts of Perilla Fructus, 9 parts of Semen Cassiae, 9 parts of Rhizoma Gastrodiae and 8 parts of Spica Prunellae.

[0037] The preparation method of the composition comprises the following steps: (1) After drying, the components were crushed into fine powders, mixed, and decocted twice with 8 times the amount of water. The mixture was filtered and combined to obtain the residue and filtrate 1 respectively. (2) The filter residue was extracted with 85% ethanol solution at 35°C for 1.5 h, and filtered to obtain filtrate 2; (3) Mix filtrate 1 and filtrate 2, concentrate them into an extract, and dry them to obtain the product.

[0038] Example 4 The only difference from Example 3 is that the total amount of Imperata cylindrica root, Ophiopogon japonicus and Forsythia suspensa leaves remains unchanged, and the dosage ratio is different, which is 3.5:1:3. Other conditions are the same.

[0039] Example 5 The only difference from Example 3 is that the total amount of Imperata cylindrica root, Ophiopogon japonicus and Forsythia suspensa leaves remains unchanged, and the dosage ratio is different, which is 4:1:2. Other conditions are the same.

[0040] Comparative Example 1 The only difference from Example 3 is that Imperata rhizome is not added, the dosage ratio of Ophiopogon japonicus and Forsythia suspensa leaves is kept unchanged, and the total dosage of the two is adjusted to 42 parts, and the other conditions are the same.

[0041] Comparative Example 2 The only difference from Example 3 is that Ophiopogon japonicus is not added, the dosage ratio of Imperata cylindrica root and Forsythia suspensa leaf is kept unchanged, and the total dosage of the two is adjusted to 42 parts, and the other conditions are the same.

[0042] Comparative Example 3 The only difference from Example 3 is that the Forsythia Leaf is not added, the dosage ratio of Imperata Rhizoma and Ophiopogon japonicus is kept unchanged, and the total dosage of the two is adjusted to 42 parts, and the other conditions are the same.

[0043] Test Example 1: Blood sugar lowering effect test Refer to the "Test Method for Maintaining Healthy Blood Sugar Levels" in the "Islet Damage Hyperglycemia Model" in the "Health Food Functional Test and Evaluation Methods (2023 Edition)" to test the blood sugar lowering effect.

[0044] ICR male mice weighing 24-28g were fasted for 5 hours before modeling, and their fasting blood glucose was measured as a baseline. Following this, they fasted for 24 hours and were injected with 130 mg / kg BW / ip of alloxan for modeling. Five days later, they fasted for 5 hours and measured their fasting blood glucose (pre-experimental blood glucose level). A blood glucose level of 10-25 mmol / L indicated successful modeling. The mice were randomly divided into nine groups of eight mice each. One group served as a model control and was administered the solvent (water). The remaining eight groups were gavage-administered with the compositions of Examples 1-5 and Comparative Examples 1-3 at a dose of 0.4 g / kg. Thirty days later, they fasted for 5 hours and measured their fasting blood glucose (post-experimental blood glucose level). The blood glucose levels and percentage reductions in blood glucose were compared among the groups.

[0045] The formula for calculating the blood sugar reduction rate is: .

[0046] The results are shown in Table 1.

[0047] Table 1 Hypoglycemic test results

[0048] Note: Compared with the model control group, *p<0.05, **p<0.01, ***p<0.001; compared with the Example 3 group, &p<0.05.

[0049] Test Example 2: Blood Pressure Lowering Effect Test Refer to the "Test Method for Helping to Maintain Healthy Blood Pressure Levels" in the "Health Food Functional Testing and Evaluation Methods (2023 Edition)" to test the blood pressure lowering effect.

[0050] Spontaneously hypertensive SD rats (systolic arterial blood pressure 155-165 mmHg), half male and half female, weighing 180-220 g, were randomly divided into nine groups of eight rats each. After one week of normal feeding, the rats were administered. One group served as a model control and was administered the solvent (water). The remaining eight groups were gavage-administered with the compositions of Examples 1-5 and Comparative Examples 1-3 at a dose of 0.4 g / kg. Arterial blood pressure (systolic blood pressure) was measured before and 30 days after the experiment. The results are shown in Table 2. Table 2 Blood pressure lowering test results

[0051] Note: Compared with the model control group, *p<0.05, **p<0.01, ***p<0.001; compared with the Example 3 group, &p<0.05.

[0052] Test Example 3: Uric Acid Lowering Effect Test Male Kunming mice weighing 18-22g were randomly divided into 11 groups of 8 mice each after one week of adaptive feeding. A 10mg / mL potassium oxonate solution was prepared and gavage was performed daily at 10mL / kg to establish the model. Ten groups underwent gavage for modeling, while the remaining group served as a blank control group and received an equal volume of water. This cycle lasted for 7 days. All model mice were successfully established, and there was no significant difference in serum uric acid levels among the groups (p>0.05). Seven days later, one group of model mice served as the model control group and received gavage with water, while another group served as the positive control group and received gavage with allopurinol solution (5mg / mL, 10mL / kg per day). The remaining eight groups of model mice received gavage with the compositions of Examples 1-5 and Comparative Examples 1-3 at a dose of 0.4g / kg. The model control and blank controls received gavages with an equal volume of water. After 7 days, serum uric acid levels were measured by collecting eye blood after the final dose, and the serum uric acid levels were measured. The results are shown in Table 3.

[0053] Table 3 Uric acid lowering test results

[0054] Note: Compared with the model control group, *p<0.05, **p<0.01, ***p<0.001; compared with the Example 3 group, &p<0.05.

[0055] The above detailed description is a specific description of one feasible embodiment of the present invention. This embodiment is not intended to limit the patent scope of the present invention. Any equivalent implementation or modification that does not depart from the present invention should be included in the scope of the technical solution of the present invention.

Claims

1. A composition for lowering blood sugar, blood pressure and uric acid, characterized in that: The invention comprises the following components by weight: 5-12 parts of corn silk, 10-30 parts of Imperata root, 10-20 parts of coix seed, 10-15 parts of reed root, 10-20 parts of yellow mustard seed, 10-15 parts of dried tangerine peel, 10-15 parts of purslane, 10-25 parts of ginseng, 10-20 parts of kudzu root, 5-10 parts of mulberry leaf, 5-10 parts of black plum, 25-35 parts of astragalus, 5-15 parts of codonopsis, 5-10 parts of ophiopogon, 12-18 parts of forsythia leaf, 12-18 parts of raw rehmannia root, 6-15 parts of scutellaria leaf, 10-25 parts of cooked rehmannia root. 6-15 parts of Radix Angelicae Dahuricae, 6-15 parts of Hippophae Rhamnoides, 10-20 parts of Angelicae Dahuricae, 5-10 parts of Rosemary, 2-8 parts of Licorice, 10-15 parts of Lilium, 20-30 parts of Honeysuckle, 8-20 parts of Eucommia ulmoides leaves, 10-20 parts of Polygonatum odoratum, 10-20 parts of Chinese Yam, 5-15 parts of Polygonatum sibiricum, 6-12 parts of Cistanche deserticola, 8-15 parts of Panax notoginseng leaves, 20-30 parts of Cornus officinalis, 6-12 parts of Taraxacum, 5-10 parts of Sophora japonica seeds, 5-10 parts of Perilla frutescens, 6-12 parts of Cassia seed, 6-12 parts of Gastrodia elata and 5-10 parts of Prunella vulgaris.

2. The composition according to claim 1, characterized in that The composition also includes spices.

3. The composition according to claim 2, characterized in that The spice comprises at least one of angelica, turmeric, tsaoko, longan, pepper, fructus amomi, cyperus rotundus, clove, fennel and bay leaf.

4. The composition according to claim 1, characterized in that The mass ratio of Imperata rhizome, Ophiopogon japonicus and Forsythia suspensa leaves is 3.5-4:1:2-3.

5. The method for preparing the composition according to any one of claims 1 to 4, characterized in that: The method comprises the following components: (1) boiling each component with water, filtering, and obtaining a filter residue and a filtrate 1; (2) Extract the filter residue with ethanol solution and filter to obtain filtrate 2; (3) Mix filtrate 1 and filtrate 2, concentrate them into an extract, and dry them to obtain the product.

6. The preparation method according to claim 5, characterized in that In step (1), each component is dried and crushed before being decocted with water; in step (1), the decocting is performed 1-3 times, and the filtrates are filtered and combined to obtain filtrate 1.

7. The preparation method according to claim 6, characterized in that The pulverizing is specifically pulverizing into fine powder.

8. The preparation method according to claim 5, characterized in that In step (2), the volume concentration of the ethanol solution is 70-90%, the extraction temperature is 30-40° C., and the extraction time is 1-2 h.

9. Use of the composition according to any one of claims 1 to 4 or the composition prepared by the preparation method according to any one of claims 5 to 8 in the preparation of a product for lowering blood sugar, and / or blood pressure, and / or uric acid.

10. The use according to claim 9, characterized in that The product is a tea product, food, health product, medicine or food additive.

Citation Information

Patent Citations

  • Hotpot seasoning and production method thereof

    CN106901303A

  • Islamic composite seasoning capable of reducing blood sugar, reducing salt and reducing blood lipid

    CN108095022A