Dehydration device for neuropathological tissue

Abstract

The invention relates to the technical field of medical detection equipment, and particularly provides a dehydration device for neuropathological tissues. The dehydration device for the neuropathological tissue comprises a dehydration moving bottom frame, a main heating assembly, a vacuum pump, a lower temperature equalizing assembly, a dehydration assembly and an upper temperature equalizing assembly. Multi-sensor fusion and point distribution are adopted to monitor the negative pressure value and local temperature distribution in the middle pipe body and the outer wrapping closed cylinder, all-region temperature and pressure monitoring is achieved, temperature and pressure changes are rapidly responded, meanwhile, heating airflow can be effectively guided and shunted, and the heating efficiency is improved. According to the system, the conditions of heating gas retention, temperature stratification or flowing dead angles are avoided, circulation uniformity and pressure uniformity are ensured, liquid entering the solution pipeline is rapidly and preliminarily heated through the plate heat exchanger, and the risk of paraffin solidification or overheating caused by temperature fluctuation caused by thermal inertia is reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of medical detection equipment, and in particular provides a dehydration device for neuropathological tissue. Background Art

[0002] When biological tissue is dehydrated, osmosis is used. This involves placing the tissue in ethanol solutions of increasing concentrations for osmosis (for example, 70%, 80%, 90%, 95%, and 100% ethanol solutions). The ethanol solution causes the water in the tissue to seep out, replacing it with ethanol. Vacuum dehydration devices utilize a vacuum environment to lower the boiling point of the liquid, accelerating the evaporation and replacement of water and alcohol within the tissue, thereby achieving rapid dehydration. However, the existing vacuum dehydration equipment lacks an automatic feedback adjustment system, resulting in the inability to accurately adjust the vacuum degree in real time, affecting the penetration efficiency and, in turn, the thoroughness of penetration. At the same time, there is also the problem of poor circulation of the heat transfer medium, which leads to uneven temperature distribution in the cavity, making some areas prone to overheating or insufficient temperature. In addition, since pathological tissues (such as brain tissue, nerve fibers, etc.) have fragile structures, high water content, and strong antigen sensitivity, when temperature unevenness or incomplete penetration occurs, it is easy to cause tissue protein denaturation, and even hardening and brittleness, affecting the quality of the slices, or causing water residue in the tissue, affecting transparency and embedding effects, and affecting the accuracy of pathological diagnosis. Summary of the Invention

[0003] Based on this, it is necessary to provide a dehydration device for neuropathological tissue to solve at least one technical problem in the background technology.

[0004] A dehydration device for neuropathological tissue comprises a dehydration movable base, a main heating component, a vacuum pump, a lower temperature equalizing component, a dehydration component and an upper temperature equalizing component. A dehydration placement seat is provided at one end of the top of the dehydration movable base, and a pump body placement seat is provided at the other end of the top of the dehydration movable base. The main heating component comprises a main heating shell and a main heating element. The bottom of the main heating shell is installed on the top of the dehydration placement seat. A suction cavity is formed in the hollow interior of the main heating shell. Suction fan grooves are respectively recessed in the middle of the two ends of the suction cavity. Eight lifting columns are arranged in an array at the bottom of the suction cavity. A suction fan groove is recessed at one end of the bottom inner side of the suction cavity. A liquid injection mounting hole is provided, and a first ventilation groove is recessed in the middle of the top surface of the suction chamber. The main heating element is installed in the suction chamber. Dehydration racks are respectively provided on the tops of both ends of the main heating shell. The bottom of the vacuum pump is installed on the top of the pump body placement seat. The bottom of the lower temperature equalizing component is installed on the top of the main heating shell. Temperature equalizing mounting turntables are respectively provided at both ends of the inner side of the lower temperature equalizing component. Buckles are respectively provided at both ends of the outer side of the lower temperature equalizing component. Both ends of the dehydration component are respectively installed on the tops of the two dehydration racks. The middle part of the dehydration component is installed in the lower temperature equalizing component. The two ends of the inner side of the upper temperature equalizing component are respectively rotatably installed in the two temperature equalizing mounting turntables.

[0005] As a further improvement of the present invention, the main heating element includes two suction fans, two plate heat exchangers, a central liquid injection pipe and three solution pipelines. The two suction fans are respectively installed in two suction fan grooves. The four corners of the bottom of the two plate heat exchangers are respectively installed on the top of eight lifting columns. The outer end of the central liquid injection pipe is installed in the liquid injection mounting hole. A liquid separation valve is provided in the central liquid injection pipe. Three liquid separation pipes are provided at the inner end of the central liquid injection pipe. One end of the three solution pipelines is respectively installed in the three liquid separation pipes, and the other end of the solution pipeline is wound around and passed through the two plate heat exchangers and is provided in the first ventilation groove.

[0006] As a further improvement of the present invention, the lower temperature equalizing component includes a lower temperature equalizing shell, a lower guide shell element and a lower temperature equalizing element. The bottom of the lower temperature equalizing shell is installed on the top of the main heating shell, two temperature equalizing installation turntables are arranged at the two ends of the inner side of the lower temperature equalizing shell, and two clips are arranged at the two ends of the outer side of the lower temperature equalizing shell. The lower temperature equalizing shell is hollow inside to form a lower installation cavity, the lower installation cavity is connected to the first ventilation groove, the lower guide shell element is installed on the top of the lower installation cavity, and the lower temperature equalizing element is installed in the lower guide shell element.

[0007] As a further improvement of the present invention, the upper temperature equalizing component includes an upper temperature equalizing shell, an upper guide shell element and an upper temperature equalizing element. The two ends of the inner side of the upper temperature equalizing shell are respectively rotatably installed in two temperature equalizing installation turntables. Two locking blocks are respectively recessed at the two ends of the outer side of the upper temperature equalizing shell. The interior of the upper temperature equalizing shell is hollow to form an upper installation cavity. Motor mounting strips are respectively protruding on both sides of the top surface of the upper installation cavity. Multiple temperature equalizing heating fans are arranged between the two motor mounting strips along the length direction. The bottom of the upper guide shell element is installed at the bottom of the upper installation cavity, and the upper temperature equalizing element is installed in the upper guide shell element.

[0008] As a further improvement of the present invention, the lower guide shell element and the upper guide shell element both include a trapezoidal shell and two symmetrically arranged diverter guide bars. The trapezoidal shell is installed at the top of the lower mounting cavity or the bottom of the upper mounting cavity. Connecting guide grooves are respectively recessed in the middle of both sides of the trapezoidal shell. Four air outlet grooves are recessed in the middle of the inner wall of the trapezoidal shell at intervals along the length direction. The inner sides of the two diverter guide bars are respectively installed at the top of both sides of the trapezoidal shell, and the bottom surface of each diverter guide bar is inclined downward. The outer bottom of the diverter guide bar is recessed with an arc-shaped guide surface, and the outer side of the bottom surface of the diverter guide bar is recessed with a discharge guide groove.

[0009] As a further improvement of the present invention, the lower temperature equalizing element and the upper temperature equalizing element each include four connecting arc plates and three temperature equalizing arc cylinders. The outer walls of the four connecting arc plates and the three temperature equalizing arc cylinders are installed on the inner wall of the trapezoidal shell along the length direction. The four connecting arc plates and the three temperature equalizing arc cylinders are alternately arranged, and the four connecting arc plates are respectively arranged opposite to the four air outlet grooves. The end wall of each temperature equalizing arc cylinder is recessed with a plurality of temperature equalizing through holes at intervals along the circumferential direction, and the inner wall of the temperature equalizing arc cylinder is recessed with a plurality of fitting through grooves at intervals along the circumferential direction. The plurality of fitting through grooves are respectively connected to the plurality of temperature equalizing through holes.

[0010] As a further improvement of the present invention, the three temperature-averaging arc cylinders of the lower temperature-averaging element are all recessed with filling holes in the middle of their inner walls, and the bottoms of the three filling holes are respectively connected to the tops of the three solution pipelines; one of the temperature-averaging arc cylinders of the upper temperature-averaging element is also recessed with a preset placement groove in the middle of its inner wall.

[0011] As a further improvement of the present invention, a conical annular groove is recessed on the outer wall of each connecting arc-shaped piece, and a plurality of temperature-averaging connecting holes are recessed on the end wall of the connecting arc-shaped piece at intervals along the circumferential direction. The plurality of temperature-averaging connecting holes are all connected to the conical annular groove, and the plurality of temperature-averaging connecting holes are respectively connected to the plurality of temperature-averaging through holes. A plurality of spiral pieces are arranged at intervals along the circumferential direction in the conical annular groove, and the plurality of spiral pieces are alternately arranged with the plurality of temperature-averaging connecting holes.

[0012] As a further improvement of the present invention, the dehydration assembly includes an intermediate tube body, an outer closed cylinder and a transfer element, the two ends of the intermediate tube body are respectively installed in two dehydration placement racks, and one end of the intermediate tube body is connected to the vacuum pump through a pipeline, and the other end of the intermediate tube body is provided with a control valve, a plurality of intermediate communicating holes are recessed in a circumferential array in the middle of the outer wall of the intermediate tube body, two preset installation grooves are recessed in the middle of the outer wall of the intermediate tube body, three placement platforms are spaced apart along the length direction at the bottom of the inner wall of the intermediate tube body, the three placement platforms are respectively arranged opposite to the three temperature-uniform arc cylinders, and the three placement platforms are respectively arranged alternately with the two preset installation grooves, a preset transfer chute is recessed in the middle of the top surface of the intermediate tube body, closed installation rings are respectively protruded at both ends of the inner wall of the outer closed cylinder, and the inner walls of the two closed installation rings are respectively installed on the two ends of the outer wall of the intermediate tube body. The bottom of the outer wall of the outer closed cylinder is installed on the inner wall of the lower temperature equalizing element. Three liquid conducting connection holes are recessed along the length direction of the bottom surface of the outer closed cylinder. The three liquid conducting connection holes are respectively connected to the three filling holes. Two partition plates are protruding from the middle of the inner wall of the outer closed cylinder. The middle parts of the two partition plates are respectively installed in two preset installation grooves. A tissue placement groove is recessed near one end of the vacuum pump on the top surface of the outer closed cylinder. A closed door is rotatably arranged in the tissue placement groove. A plurality of sensor mounting holes are spaced along the length direction on the top surface of the outer closed cylinder. Temperature sensors and pressure sensors are all provided in the plurality of sensor mounting holes. An auxiliary pump mounting hole is recessed on the top surface of the outer closed cylinder. The auxiliary pump mounting hole is arranged opposite to the preset placement groove. A pressurization auxiliary pump is provided in the auxiliary pump mounting hole. The transfer element is installed in the outer closed cylinder.

[0013] As a further improvement of the present invention, the transfer element includes two transfer rails and a telescopic transfer clamp. The two transfer rails are respectively installed on both sides of the top of the internal cavity of the outer closed cylinder. The top of the telescopic transfer clamp is slidably installed in the two transfer rails, and the bottom of the telescopic transfer clamp is passed through a preset transfer slide groove and is set at the top of the internal cavity of the intermediate tube body.

[0014] The beneficial effects of the present invention are as follows:

[0015] 1. This case uses multi-sensor fusion and point distribution to monitor the negative pressure value and local temperature distribution inside the intermediate tube body and the outer closed cylinder, realizing full-area temperature and pressure monitoring and rapid response to temperature and pressure changes to prevent local overheating from causing protein denaturation. At the same time, it can detect the real-time pressure inside the equipment and dynamically adjust the pressure reduction rate based on real-time pressure feedback to avoid sudden pressure drops. At the same time, it can effectively guide and divert the heated airflow to avoid heated gas retention, temperature stratification or flow dead corners, ensuring circulation uniformity and pressure uniformity, and using a plate heat exchanger to quickly and preliminarily heat the liquid entering the solution pipeline, reducing temperature fluctuations caused by thermal inertia, and the risk of paraffin solidification or overheating.

[0016] 2. This case realizes the advantages of dynamic negative pressure control and temperature uniformity, promotes the stratified replacement of alcohol and water molecules, avoids tissue contraction due to continuous high pressure, reduces the shrinkage rate of pathological tissue after dehydration, and realizes low-temperature circulation (<60°C) and rapid dehydration (4-6 hours in total), effectively reducing antigen degradation. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 FIG. 1 is a perspective schematic diagram of an embodiment of the present invention.

[0018] Figure 2 This is a schematic diagram of the interior of an embodiment of the present invention after removing the dehydration movable chassis and the vacuum pump.

[0019] Figure 3 Schematic diagram of the bottom temperature equalizing assembly and the dehydration assembly in one embodiment of the present invention.

[0020] Figure 4 Schematic diagram of the interior of the upper temperature equalizing component in one embodiment of the present invention.

[0021] Figure 5 1 is an exploded view of the lower temperature uniformity element in one embodiment of the present invention.

[0022] Figure 6 Schematic diagram of the interior of the connected arc-shaped pieces in one embodiment of the present invention.

[0023] Figure 7 Schematic diagram of the interior of the lower temperature equalizing component and the dehydration component in one embodiment of the present invention.

[0024] Figure 8 This is a broken view of the interior of a dehydration assembly in one embodiment of the present invention.

[0025] In the picture:

[0026] 10. Dehydration movable chassis; 11. Dehydration placement seat; 12. Pump body placement seat; 20. Main heating assembly; 21. Main heating shell; 22. Main heating element; 211. Suction cavity; 212. Suction fan slot; 213. Lifting column; 214. Liquid injection installation hole; 215. First ventilation slot; 216. Dehydration placement rack; 221. Suction fan; 222. Plate heat exchanger; 30. Vacuum pump; 40. Lower temperature equalization assembly; 41. Temperature equalization installation turntable; 411. Buckle; 42. Lower temperature equalization shell; 43. Lower guide shell element; 44. Lower temperature equalization element; 421. Lower installation cavity; 60. Upper temperature equalization assembly; 61. Upper temperature equalization shell; 62. Upper guide shell element; 63. Upper temperature equalization element; 611. Lock block; 612. Upper installation cavity; 613. Motor installation bar ;71. Trapezoidal shell;72. Diverter guide strip;73. Connecting guide groove;74. Air outlet groove;75. Arc-shaped guide surface;76. Discharge guide groove;81. Connecting arc-shaped piece;82. Temperature-equalizing arc-shaped cylinder;821. Temperature-equalizing through hole;822. Fitting through groove;823. Filling through hole;811. Conical annular groove;812. Temperature-equalizing connecting hole;813. Spiral piece;50. Dehydration assembly;51. Intermediate tube body;52. Outer closed cylinder;53. Transfer element;511. Control valve;512. Intermediate connecting hole;513. Preset mounting groove;514. Preset transfer slide;521. Closed mounting ring;522. Liquid guide connecting through hole;523. Partition plate;524. Tissue placement groove;525. Auxiliary pump mounting hole;531. Transfer rail;532. Telescopic transfer clamp. DETAILED DESCRIPTION

[0027] To facilitate understanding of the present invention, the present invention will be described more fully below with reference to the accompanying drawings. The accompanying drawings illustrate preferred embodiments of the present invention. However, the present invention may be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and comprehensive understanding of the present disclosure.

[0028] In the description of the present invention, it should be noted that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0029] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one skilled in the art to which this invention pertains. The terms used herein are for the purpose of describing specific embodiments only and are not intended to limit the present invention. As used herein, the term "and / or" includes any and all combinations of one or more of the associated listed items.

[0030] See also Figures 1 to 8 A dehydration device for neuropathological tissue comprises a dehydration movable base 10, a main heating component 20, a vacuum pump 30, a lower temperature equalizing component 40, a dehydration component 50 and an upper temperature equalizing component 60. A dehydration placement seat 11 is provided at one end of the top of the dehydration movable base 10, and a pump body placement seat 12 is provided at the other end of the top of the dehydration movable base 10. The main heating component 20 comprises a main heating shell 21 and a main heating element 22. The bottom of the main heating shell 21 is installed on the top of the dehydration placement seat 11. A suction cavity 211 is formed hollow inside the main heating shell 21. Suction fan grooves 212 are respectively recessed in the middle of the two ends of the suction cavity 211. Eight lifting columns 213 are arranged in an array at the bottom of the suction cavity 211. One end of the bottom inner side of the suction cavity 211 is recessed. There is a liquid injection mounting hole 214, and a first ventilation groove 215 is recessed in the middle of the top surface of the suction chamber 211. The main heating element 22 is installed in the suction chamber 211. Dehydration racks 216 are respectively provided on the tops of both ends of the main heating shell 21. The bottom of the vacuum pump 30 is installed on the top of the pump body placement seat 12. The bottom of the lower temperature equalizing component 40 is installed on the top of the main heating shell 21. The two ends of the inner side of the lower temperature equalizing component 40 are respectively provided with temperature equalizing mounting turntables 41. The two ends of the outer side of the lower temperature equalizing component 40 are respectively provided with buckles 411. The two ends of the dehydration component 50 are respectively installed on the tops of the two dehydration racks 216. The middle part of the dehydration component 50 is installed in the lower temperature equalizing component 40. The two ends of the inner side of the upper temperature equalizing component 60 are respectively rotatably installed in the two temperature equalizing mounting turntables 41.

[0031] The main heating element 22 includes two suction fans 221, two plate heat exchangers 222, a central liquid injection pipe and three solution pipelines. The two suction fans 221 are respectively installed in the two suction fan grooves 212. The four corners of the bottom of the two plate heat exchangers 222 are respectively installed on the top of eight lifting columns 213. The outer end of the central liquid injection pipe is installed in the liquid injection mounting hole 214. A liquid separation valve is provided in the central liquid injection pipe. Three liquid separation pipes are provided at the inner end of the central liquid injection pipe. One end of the three solution pipelines is respectively installed in the three liquid separation pipes, and the other end of the solution pipeline is passed through the two plate heat exchangers 222 and is provided in the first ventilation groove 215.

[0032] The lower temperature equalizing component 40 includes a lower temperature equalizing shell 42, a lower guide shell element 43 and a lower temperature equalizing element 44. The bottom of the lower temperature equalizing shell 42 is installed on the top of the main heating shell 21. Two temperature equalizing mounting turntables 41 are arranged at the two ends of the inner side of the lower temperature equalizing shell 42. Two clips 411 are arranged at the two ends of the outer side of the lower temperature equalizing shell 42. The interior of the lower temperature equalizing shell 42 is hollow to form a lower mounting cavity 421. The lower mounting cavity 421 is connected to the first ventilation groove 215. The lower guide shell element 43 is installed on the top of the lower mounting cavity 421. The lower temperature equalizing element 44 is installed in the lower guide shell element 43.

[0033] The upper temperature equalizing component 60 includes an upper temperature equalizing shell 61, an upper guide shell element 62 and an upper temperature equalizing element 63. The two ends of the inner side of the upper temperature equalizing shell 61 are respectively rotatably installed in two temperature equalizing installation turntables 41. Two locking blocks 611 are respectively recessed at the two ends of the outer side of the upper temperature equalizing shell 61. The interior of the upper temperature equalizing shell 61 is hollow to form an upper installation cavity 612. Motor installation strips 613 are respectively protruding on both sides of the top surface of the upper installation cavity 612. Multiple temperature equalizing heating fans are arranged along the length direction between the two motor installation strips 613. The bottom of the upper guide shell element 62 is installed at the bottom of the upper installation cavity 612, and the upper temperature equalizing element 63 is installed in the upper guide shell element 62.

[0034] The lower guide shell element 43 and the upper guide shell element 62 both include a trapezoidal shell 71 and two symmetrically arranged diverter guides 72. The trapezoidal shell 71 is installed at the top of the lower mounting cavity 421 or the bottom of the upper mounting cavity 612. A connecting guide groove 73 is respectively recessed in the middle of both sides of the trapezoidal shell 71. Four air outlet grooves 74 are recessed in the middle of the inner wall of the trapezoidal shell 71 at intervals along the length direction. The inner sides of the two diverter guides 72 are respectively installed at the top of both sides of the trapezoidal shell 71, and the bottom surface of each diverter guide 72 is inclined downward. An arc-shaped guide surface 75 is recessed in the bottom outer side of the diverter guide 72, and a discharge guide groove 76 is recessed on the outer side of the bottom surface of the diverter guide 72.

[0035] The lower temperature equalizing element 44 and the upper temperature equalizing element 63 both include four connecting arc-shaped pieces 81 and three temperature equalizing arc-shaped cylinders 82. The outer walls of the four connecting arc-shaped pieces 81 and the three temperature equalizing arc-shaped cylinders 82 are all installed on the inner wall of the trapezoidal shell 71 along the length direction. The four connecting arc-shaped pieces 81 and the three temperature equalizing arc-shaped cylinders 82 are alternately arranged, and the four connecting arc-shaped pieces 81 are respectively arranged opposite to the four air outlet grooves 74. The end wall of each temperature equalizing arc-shaped cylinder 82 is recessed with a plurality of temperature equalizing through holes 821 at intervals along the circumferential direction, and the inner wall of the temperature equalizing arc-shaped cylinder 82 is recessed with a plurality of fitting through grooves 822 at intervals along the circumferential direction. The plurality of fitting through grooves 822 are respectively connected to the plurality of temperature equalizing through holes 821.

[0036] The three temperature-averaging arc cylinders 82 of the lower temperature-averaging element 44 are all recessed with filling holes 823 in the middle of their inner walls, and the bottoms of the three filling holes 823 are respectively connected to the tops of the three solution pipelines; one of the temperature-averaging arc cylinders 82 of the upper temperature-averaging element 63 is also recessed with a preset placement groove in the middle of its inner wall.

[0037] The outer wall of each connecting arc piece 81 is recessed with a conical annular groove 811, and the end wall of the connecting arc piece 81 is recessed with a plurality of temperature-averaging connecting holes 812 at intervals along the circumferential direction. The plurality of temperature-averaging connecting holes 812 are all connected to the conical annular groove 811, and the plurality of temperature-averaging connecting holes 812 are respectively connected to a plurality of temperature-averaging through holes 821. A plurality of spiral pieces 813 are arranged at intervals along the circumferential direction in the conical annular groove 811, and the plurality of spiral pieces 813 are alternately arranged with the plurality of temperature-averaging connecting holes 812.

[0038] The dehydration assembly 50 includes an intermediate tube body 51, an outer sealing cylinder 52 and a transfer element 53. The two ends of the intermediate tube body 51 are respectively installed in two dehydration placement racks 216, and one end of the intermediate tube body 51 is connected to the vacuum pump 30 through a pipeline. The other end of the intermediate tube body 51 is provided with a control valve 511. A plurality of intermediate communicating holes 512 are recessed in a circumferential array in the middle of the outer wall of the intermediate tube body 51. Two preset installation grooves 513 are recessed in the middle of the outer wall of the intermediate tube body 51. Three placement platforms are spaced apart along the length direction at the bottom of the inner wall of the intermediate tube body 51. The three placement platforms are respectively arranged opposite to the three temperature-averaging arc cylinders 82, and the three placement platforms are respectively arranged alternately with the two preset installation grooves 513. A preset transfer slide groove 514 is recessed in the middle of the top surface of the intermediate tube body 51. Closed mounting rings 521 are respectively protruded at both ends of the inner wall of the outer sealing cylinder 52. The inner walls of the two closed mounting rings 521 are respectively installed at the two ends of the outer wall of the intermediate tube body 51. The bottom of the outer wall is mounted on the inner wall of the lower temperature-averaging element 44. Three liquid-conducting connection holes 522 are recessed on the bottom surface of the outer closed cylinder 52 at intervals along its length. The three liquid-conducting connection holes 522 are respectively connected to the three filling holes 823. Two partition plates 523 are protruding from the middle of the inner wall of the outer closed cylinder 52. The middle of the two partition plates 523 are respectively mounted in two preset mounting grooves 513. A tissue placement groove 524 is recessed on the top surface of the outer closed cylinder 52, adjacent to one end of the vacuum pump 30. A closed door is rotatably mounted in the tissue placement groove 524. A plurality of sensor mounting holes are recessed on the top surface of the outer closed cylinder 52 at intervals along its length. Temperature sensors and pressure sensors are each mounted in each of the plurality of sensor mounting holes. An auxiliary pump mounting hole 525 is recessed on the top surface of the outer closed cylinder 52. The auxiliary pump mounting hole 525 is positioned opposite the preset placement groove. A pressurization auxiliary pump is mounted in the auxiliary pump mounting hole 525. The transfer element 53 is mounted in the outer closed cylinder 52.

[0039] The transfer element 53 includes two transfer rails 531 and a telescopic transfer clamp 532. The two transfer rails 531 are respectively installed on both sides of the top of the internal cavity of the outer sealing tube 52. The top of the telescopic transfer clamp 532 is slidably installed in the two transfer rails 531, and the bottom of the telescopic transfer clamp 532 is passed through a preset transfer slide groove 514 and is set at the top of the internal cavity of the intermediate tube body 51.

[0040] For example, in one embodiment, the plate heat exchanger 222 is connected to the heating pipe.

[0041] For example, in one embodiment: when it is necessary to dehydrate the neuropathological tissue, open the upper temperature-averaging component 60, rotate it and move it upward, then open the closed door, place the neuropathological tissue on the placement table opposite to the tissue placement slot 524, then close the closed door and the upper temperature-averaging component 60, and lock the two locking blocks 611 in the two buckles 411, then connect the external alcohol filling device to the liquid injection mounting hole 214 and start it, and inject alcohol of various concentrations into the bottom of the outer closed cylinder 52 through the central liquid injection pipe, three solution pipelines and three filling through holes 823, and since a plurality of intermediate connecting holes 512 are recessed in a circular array in the middle of the outer wall of the intermediate tube body 51, alcohol of different concentrations will enter the bottom of the intermediate tube body 51 and be separated by two partition plates 523, then close the liquid separation valve and start the vacuum pump 30 to vacuum the intermediate tube body 51 and the outer closed cylinder 52 The air is extracted so that the middle tube body 51 and the outer closed tube 52 maintain a low pressure in the whole cavity (the pressure range is 0.08-0.1MPa), promote the gentle penetration of low-concentration alcohol, and avoid the collapse of brittle tissue. Subsequently, after the low-concentration alcohol replacement is completed, the telescopic transfer clamp 532 will be started to clamp the neuropathological tissue and transfer it to the placement table where high-concentration alcohol is placed. At the same time, the pressure sensors in the multiple sensor mounting holes will identify the pressure of the outer closed tube 52 and start the pressurization auxiliary pump to perform pressure fine-tuning, so that the middle tube body 51 and the outer closed tube 52 enter the deep dehydration replacement stage (the pressure range is 0.05-0.08MPa), and the process of fine-tuning the pressure of the pressurization auxiliary pump adopts intermittent negative pressure setting, using pressure fluctuations to promote the stratified replacement of alcohol and water molecules, and avoid tissue contraction due to continuous high pressure, so as to accelerate the replacement of water by alcohol and shorten the dehydration time.

[0042] After the gradient alcohol dehydration is completed, the external alcohol filling device is disconnected, the alcohol recovery device is connected to the liquid injection installation hole 214 and started, and the control valve 511 and the liquid separation valve are opened to recover the waste liquid of the alcohol. Subsequently, the external alcohol recovery device is disconnected again and the filling device for the clarifier and liquid paraffin is connected to the liquid injection installation hole 214. The clarifier and liquid paraffin are respectively injected into the intermediate tube body 51 and the outer sealing cylinder 52 and separated by two partitions 523. The vacuum pump 30 is restarted and the above-mentioned workflow is carried out to quickly complete the replacement of the clarifier and the wax impregnation process. Subsequently, the liquid separation valve is closed and the recovery device is connected to the liquid injection installation hole 214 to recover the waste liquid of the clarifier and liquid paraffin.

[0043] For example, in one embodiment, when alcohol, a transparent agent, or liquid paraffin passes through the solution pipeline, the solution pipeline is wound through the two plate heat exchangers 222, and its temperature is evenly increased during the reflow process. At the same time, the two suction fans 221 are started to draw in the external air, and the air is heated by the top plate heat exchanger 222 to form a lower heated air flow. The lower heated air flow will pass through the first ventilation groove 215 and the lower mounting cavity 421 and impact the trapezoidal shell 71 of the lower guide shell element 43, so that part of the lower heated air flow passes through the four air outlet grooves 74 and enters the four connecting arc-shaped pieces 81. The air flows into the conical annular groove 811 and is accelerated by the multiple spiral blades 813 therein to enter the multiple temperature-equalizing connecting holes 812, and then enters the multiple temperature-equalizing through holes 821 and the multiple fitting through grooves 822, thereby performing temperature-equalizing adjustment on the bottom of the outer wall of the outer closed tube 52. In addition, another portion of the lower heated airflow will also be guided by the arc-shaped guide surface 75 and the diversion guide strip 72 through the discharge guide groove 76 and the connecting guide groove 73 to merge into the two sides of the conical annular groove 811, and then enter the temperature-equalizing through holes 821 and the multiple fitting through grooves 822, thereby performing temperature-equalizing adjustment on the bottom of the outer wall of the outer closed tube 52. At the same time, the multiple temperature-equalizing heating fans of the upper temperature-equalizing component 60 will also be started, thereby generating an upper heated airflow to synchronously heat the top of the outer closed tube 52. Multiple temperature sensors will detect the temperature of the internal cavity of the intermediate tube 51 and the outer closed tube 52, realizing full-area temperature monitoring and rapid response to temperature changes, ensuring the uniformity of the measured temperature and the actual temperature.

[0044] Installation process: Install the bottom of the vacuum pump 30 on the top of the pump body placement seat 12, install the two suction fans 221 in the two suction fan slots 212 respectively, install the four corners of the bottom of the two plate heat exchangers 222 on the top of the eight lifting columns 213 respectively, install the outer end of the central injection pipe in the injection installation hole 214, install one end of the three solution pipelines in the three liquid distribution pipes respectively, and the other end of the solution pipeline is passed through the two plate heat exchangers 222 and installed in the first ventilation slot 215. The bottom of the lower temperature-averaging shell 42 is installed on the top of the main heating shell 21, and the two ends of the inner side of the upper temperature-averaging shell 61 are respectively rotated and installed in the two temperature-averaging turntables 41. The trapezoidal shell 71 is installed on the top of the lower installation cavity 421 or the bottom of the upper installation cavity 612. The inner sides of the two diverter guides 72 are respectively installed on the top of both sides of the trapezoidal shell 71, and the bottom surface of each diverter guide 72 is set downwardly. The outer walls of the four connecting arc pieces 81 and the three temperature-averaging arc cylinders 82 are installed along the length direction. On the inner wall of the trapezoidal shell 71, four connecting arc pieces 81 and three temperature-averaging arc cylinders 82 are alternately arranged, and the four connecting arc pieces 81 are respectively arranged opposite to the four air outlet grooves 74, and the bottoms of the three filling holes 823 are respectively connected to the tops of the three solution pipelines, and the two ends of the intermediate tube body 51 are respectively installed in the two dehydration racks 216, and one end of the intermediate tube body 51 is connected to the vacuum pump 30 through a pipeline, the inner walls of the two closed mounting rings 521 are respectively installed at the two ends of the outer wall of the intermediate tube body 51, and the bottom of the outer wall of the outer closed cylinder 52 is installed on the inner wall of the lower temperature-averaging element 44, and the three liquid-conducting connecting holes 522 are respectively connected to the three filling holes 823, and the two transfer rails 531 are respectively installed on both sides of the top of the internal cavity of the outer closed cylinder 52, the top of the telescopic transfer clamp 532 is slidably installed in the two transfer rails 531, and the bottom of the telescopic transfer clamp 532 is passed through the preset transfer slide 514 and is arranged at the top of the internal cavity of the intermediate tube body 51.

[0045] The present invention can achieve:

[0046] 1. This case adopts multi-sensor fusion and point distribution to monitor the negative pressure value and local temperature distribution inside the intermediate tube body 51 and the outer closed cylinder 52, realizes full-area temperature and pressure monitoring, and realizes rapid response to temperature and pressure changes to prevent local overheating from causing protein denaturation. At the same time, it can detect the real-time pressure inside the equipment and dynamically adjust the pressure reduction rate according to the real-time pressure feedback to avoid sudden pressure drops. At the same time, it can effectively guide and divert the heated airflow to avoid the occurrence of heated gas retention, temperature stratification or flow dead corners, ensure circulation uniformity and pressure uniformity, and use the plate heat exchanger 222 to quickly and preliminarily heat the liquid entering the solution pipeline, reducing temperature fluctuations caused by thermal inertia, and the risk of paraffin solidification or overheating.

[0047] 2. This case realizes the advantages of dynamic negative pressure control and temperature uniformity, promotes the stratified replacement of alcohol and water molecules, avoids tissue contraction due to continuous high pressure, reduces the shrinkage rate of pathological tissue after dehydration, and realizes low-temperature circulation (<60°C) and rapid dehydration (4-6 hours in total), effectively reducing antigen degradation.

[0048] The above-described embodiments merely represent several embodiments of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of protection of the present invention. It should be noted that a person skilled in the art would be able to make various modifications and improvements without departing from the spirit of the present invention, and these modifications and improvements fall within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be determined by the appended claims.

Claims

1. A dehydration device for neuropathological tissue, characterized in that: The invention comprises a dehydration movable base frame (10), a main heating component (20), a vacuum pump (30), a lower temperature equalizing component (40), a dehydration component (50) and an upper temperature equalizing component (60); a dehydration placement seat (11) is provided at one end of the top of the dehydration movable base frame (10); a pump body placement seat (12) is provided at the other end of the top of the dehydration movable base frame (10); the main heating component (20) comprises a main heating shell (21) and a main heating element (22); the bottom of the main heating shell (21) is installed on the top of the dehydration placement seat (11); a suction cavity (211) is formed in the hollow inside of the main heating shell (21); suction fan grooves (212) are respectively recessed at the middle of the two ends of the suction cavity (211); eight lifting columns (213) are arranged in an array at the bottom of the suction cavity (211); a liquid injection installation hole (213) is recessed at one end of the bottom of the inner side of the suction cavity (211); 214), a first ventilation groove (215) is recessed in the middle of the top surface of the suction chamber (211), the main heating element (22) is installed in the suction chamber (211), and dehydration racks (216) are protruding from the tops of both ends of the main heating shell (21), the bottom of the vacuum pump (30) is installed on the top of the pump body placement seat (12), the bottom of the lower temperature equalizing component (40) is installed on the top of the main heating shell (21), and the two ends of the inner side of the lower temperature equalizing component (40) are protruding from the temperature equalizing mounting turntable (41), and the two ends of the outer side of the lower temperature equalizing component (40) are respectively provided with buckles (411), the two ends of the dehydration component (50) are respectively installed on the tops of the two dehydration racks (216), the middle part of the dehydration component (50) is installed in the lower temperature equalizing component (40), and the two ends of the inner side of the upper temperature equalizing component (60) are respectively rotatably installed in the two temperature equalizing mounting turntables (41).

2. The dehydration device for neuropathological tissue according to claim 1, characterized in that: The main heating element (22) includes two suction fans (221), two plate heat exchangers (222), a central liquid injection pipe and three solution pipelines. The two suction fans (221) are respectively installed in the two suction fan grooves (212). The four corners of the bottom of the two plate heat exchangers (222) are respectively installed on the top of eight lifting columns (213). The outer end of the central liquid injection pipe is installed in the liquid injection installation hole (214). A liquid separation valve is provided in the central liquid injection pipe. Three liquid separation pipes are provided at the inner end of the central liquid injection pipe. One end of the three solution pipelines is respectively installed in the three liquid separation pipes. The other end of the solution pipeline is passed through the two plate heat exchangers (222) and is provided in the first ventilation groove (215).

3. The dehydration device for neuropathological tissue according to claim 2, characterized in that: The lower temperature-averaging assembly (40) includes a lower temperature-averaging shell (42), a lower guide shell element (43) and a lower temperature-averaging element (44). The bottom of the lower temperature-averaging shell (42) is installed on the top of the main heating shell (21). Two temperature-averaging mounting turntables (41) are arranged at the two ends of the inner side of the lower temperature-averaging shell (42). Two buckles (411) are arranged at the two ends of the outer side of the lower temperature-averaging shell (42). The interior of the lower temperature-averaging shell (42) is hollow to form a lower mounting cavity (421). The lower mounting cavity (421) is connected to the first ventilation groove (215). The lower guide shell element (43) is installed on the top of the lower mounting cavity (421). The lower temperature-averaging element (44) is installed in the lower guide shell element (43).

4. The dehydration device for neuropathological tissue according to claim 3, characterized in that: The upper temperature-averaging component (60) includes an upper temperature-averaging shell (61), an upper guide shell element (62) and an upper temperature-averaging element (63). The two ends of the inner side of the upper temperature-averaging shell (61) are respectively rotatably mounted in two temperature-averaging mounting turntables (41). Two locking blocks (611) are respectively recessed at the two ends of the outer side of the upper temperature-averaging shell (61). The interior of the upper temperature-averaging shell (61) is hollow to form an upper mounting cavity (612). Motor mounting strips (613) are respectively convexly provided on both sides of the top surface of the upper mounting cavity (612). A plurality of temperature-averaging heating fans are arranged between the two motor mounting strips (613) along the length direction. The bottom of the upper guide shell element (62) is mounted on the bottom of the upper mounting cavity (612), and the upper temperature-averaging element (63) is mounted in the upper guide shell element (62).

5. The dehydration device for neuropathological tissue according to claim 4, characterized in that: The lower guide housing element (43) and the upper guide housing element (62) both include a trapezoidal shell (71) and two symmetrically arranged diverter guides (72). The trapezoidal shell (71) is installed at the top of the lower mounting cavity (421) or the bottom of the upper mounting cavity (612). A connecting guide groove (73) is respectively recessed in the middle of both sides of the trapezoidal shell (71). Four air outlet grooves (74) are recessed in the middle of the inner wall of the trapezoidal shell (71) at intervals along the length direction. The inner sides of the two diverter guides (72) are respectively installed at the tops of both sides of the trapezoidal shell (71), and the bottom surface of each diverter guide (72) is inclined downward. The outer bottom of the diverter guide (72) is recessed with an arc-shaped guide surface (75), and the outer bottom surface of the diverter guide (72) is recessed with a discharge guide groove (76).

6. The dehydration device for neuropathological tissue according to claim 5, characterized in that: The lower temperature-averaging element (44) and the upper temperature-averaging element (63) each include four connecting arc-shaped pieces (81) and three temperature-averaging arc-shaped cylinders (82). The outer walls of the four connecting arc-shaped pieces (81) and the three temperature-averaging arc-shaped cylinders (82) are all mounted on the inner wall of the trapezoidal shell (71) along the length direction. The four connecting arc-shaped pieces (81) and the three temperature-averaging arc-shaped cylinders (82) are alternately arranged, and the four connecting arc-shaped pieces (81) are respectively arranged opposite to the four air outlet slots (74). The end wall of each temperature-averaging arc-shaped cylinder (82) is recessed with a plurality of temperature-averaging through holes (821) at intervals along the circumferential direction. The inner wall of the temperature-averaging arc-shaped cylinder (82) is recessed with a plurality of fitting through grooves (822) at intervals along the circumferential direction. The plurality of fitting through grooves (822) are respectively connected to the plurality of temperature-averaging through holes (821).

7. The dehydration device for neuropathological tissue according to claim 6, characterized in that: The three temperature-averaging arc cylinders (82) of the lower temperature-averaging element (44) are each recessed with a filling through hole (823) in the middle of their inner wall, and the bottoms of the three filling through holes (823) are respectively connected to the tops of the three solution pipelines; and the middle of the inner wall of one of the temperature-averaging arc cylinders (82) of the upper temperature-averaging element (63) is each recessed with a preset placement groove.

8. The dehydration device for neuropathological tissue according to claim 7, characterized in that: The outer wall of each connecting arc-shaped piece (81) is recessed with a conical annular groove (811), and the end wall of the connecting arc-shaped piece (81) is recessed with a plurality of temperature-averaging connecting holes (812) at intervals along the circumferential direction. The plurality of temperature-averaging connecting holes (812) are all connected to the conical annular groove (811), and the plurality of temperature-averaging connecting holes (812) are respectively connected to a plurality of temperature-averaging through holes (821). A plurality of spiral pieces (813) are arranged at intervals along the circumferential direction in the conical annular groove (811), and the plurality of spiral pieces (813) are respectively arranged alternately with the plurality of temperature-averaging connecting holes (812).

9. The dehydration device for neuropathological tissue according to claim 8, characterized in that: The dehydration assembly (50) includes an intermediate tube body (51), an outer sealing cylinder (52) and a transfer element (53). The two ends of the intermediate tube body (51) are respectively installed in two dehydration racks (216), and one end of the intermediate tube body (51) is connected to the vacuum pump (30) through a pipeline. The other end of the intermediate tube body (51) is provided with a control valve (511). A plurality of intermediate communication holes (512) are concavely arranged in a circumferential array in the middle of the outer wall of the intermediate tube body (51). Two preset installation grooves ( 513), three placement platforms are arranged at intervals along the length direction at the bottom of the inner wall of the intermediate tube body (51), and the three placement platforms are respectively arranged opposite to the three temperature-averaging arc cylinders (82), and the three placement platforms are respectively arranged alternately with the two preset installation grooves (513). A preset transfer chute (514) is concavely provided in the middle of the top surface of the intermediate tube body (51), and closed installation rings (521) are respectively convexly provided at both ends of the inner wall of the outer closed cylinder (52). The inner walls of the two closed installation rings (521) are respectively installed at the two ends of the outer wall of the intermediate tube body (51). The bottom of the outer wall of the cylinder (52) is mounted on the inner wall of the lower temperature equalizing element (44), and three liquid conducting connection holes (522) are recessed on the bottom surface of the outer closed cylinder (52) along the length direction. The three liquid conducting connection holes (522) are respectively connected to the three filling holes (823). Two partition plates (523) are convexly provided on the middle part of the inner wall of the outer closed cylinder (52), and the middle parts of the two partition plates (523) are respectively mounted in two preset mounting grooves (513). The top surface of the outer closed cylinder (52) is recessed on one end of the vacuum pump (30). A placement slot (524) is provided with a closed door that is rotatably arranged in the tissue placement slot (524). A plurality of sensor mounting holes are provided at intervals along the length direction on the top surface of the outer closed cylinder (52). Temperature sensors and pressure sensors are provided in the plurality of sensor mounting holes. An auxiliary pump mounting hole (525) is provided in a recessed manner on the top surface of the outer closed cylinder (52). The auxiliary pump mounting hole (525) is provided opposite to the preset placement slot. A pressurized auxiliary pump is provided in the auxiliary pump mounting hole (525). The transfer element (53) is installed in the outer closed cylinder (52).

10. The dehydration device for neuropathological tissue according to claim 9, characterized in that: The transfer element (53) includes two transfer rails (531) and a telescopic transfer clamp (532). The two transfer rails (531) are respectively installed on both sides of the top of the internal cavity of the outer closed tube (52). The top of the telescopic transfer clamp (532) is slidably installed in the two transfer rails (531), and the bottom of the telescopic transfer clamp (532) is passed through a preset transfer slide groove (514) and is set at the top of the internal cavity of the intermediate tube (51).

Images