ECMO and mesenchymal cell filter combined in-vitro membrane lung oxygenation device

Abstract

The invention belongs to the technical field of medical apparatus and instruments, and discloses an ECMO and mesenchymal cell filter combined extracorporeal membrane oxygenation device, which comprises: a cart for transferring the extracorporeal membrane oxygenation device; the gas mixer is arranged below the cart; the blood pump is arranged above the cart; through the linkage design of the three filtering layers and a layer-by-layer pressure relief mechanism, dynamic self-adaptive switching of a filtering path in a blocked state is achieved, when the pressure of a certain filtering layer rises due to blood cell blockage, the corresponding pressure relief valve is automatically opened, blood is guided to be shunted to the next filtering layer, overload rupture or blood flow interruption of a single filtering layer is avoided, and the safety of a patient is improved. The layered pressure release and filtering relay mechanism can significantly prolong the continuous operation time of the device, reduce the clinical membrane replacement frequency, and reduce the mechanical stress of a single assembly, prolong the service life of the filtering layer and reduce the operation risk through the layer-by-layer dispersion of the pressure load.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and in particular relates to an extracorporeal membrane oxygenation device combining ECMO with a mesenchymal cell filter. Background Art

[0002] ECMO is a medical emergency device. Its core parts are membrane lungs (artificial lungs) and blood pumps (artificial hearts), which can temporarily replace the patient's cardiopulmonary function.

[0003] Extracorporeal membrane oxygenation (ECMO) is one of the important medical technologies currently used to save the lives of critically ill patients. Its purpose is to replace the patient's own cardiopulmonary function to ensure adequate perfusion and oxygen supply to the patient's body.

[0004] The ECMO system is mainly composed of an extracorporeal oxygenated membrane lung, a centrifugal pump head and pipelines. The ECMO pipeline can connect the extracorporeal oxygenated membrane lung to the centrifugal pump, and connect to the blood vessels in the body through arteriovenous catheters, and draw the patient's venous blood out of the body through the centrifugal pump. When ECMO is used, under the action of the centrifugal pump, blood can be drawn from the veins of critically ill patients, absorb oxygen and discharge carbon dioxide through the membrane lung. The blood that has undergone gas exchange can return to the veins or arteries under the action of the centrifugal pump according to clinical treatment needs, and can provide extracorporeal respiratory support and cardiac support respectively. When the patient's lung function or heart function is severely damaged, ECMO can take on both the oxygenation function of the lungs and the pumping function of the heart, thereby buying precious time for the patient's treatment.

[0005] The extracorporeal membrane oxygenation device with ECMO and mesenchymal cell filter refers to adding a mesenchymal cell filter to the ECMO system to filter cells in the blood through the mesenchymal cell component. However, in the above process, the filter medium inside the mesenchymal cell component causes blood flow to be obstructed due to the accumulation of cells in the filter medium after filtering the blood, thereby increasing the blood flow resistance. Not only does it require the blood pump to provide greater power to maintain the blood flow rate, but the normal flow state of the blood may also be affected by local pressure changes. Summary of the Invention

[0006] The present invention addresses the problem in the prior art that, due to the accumulation of cells in the filter medium inside the mesenchymal cell assembly after filtering blood, blood flow is obstructed, resulting in increased blood flow resistance. This not only requires the blood pump to provide greater power to maintain blood flow rate, but also may affect the normal flow state of blood due to local pressure changes. The following technical solutions are proposed:

[0007] An extracorporeal membrane oxygenation device combined with ECMO and a mesenchymal cell filter, comprising: a cart for transferring the extracorporeal membrane oxygenation device;

[0008] a gas mixer, disposed below the cart;

[0009] a blood pump, arranged above the cart;

[0010] a membrane separator, arranged on the outside of the cart;

[0011] The mesenchymal cell assembly includes a housing, a filter medium, a conical cover, a flow guide tube, a pressure relief valve, a filter layer, and a flow rate enhancement structure;

[0012] The conical cover is connected to the cart through the shell, the filter layer is connected to the conical cover, the pressure relief valve is connected to the conical cover through the guide tube, and the flow rate enhancement structure is connected to the guide tube;

[0013] The patient's venous blood is drawn out of the body through the blood pump, oxygenated in turn through the membrane separator, and then enters the mesenchymal cell assembly. At this time, it enters the outside of the filter layer through the conical cover, and enters the second filter layer along the guide tube by driving the pressure relief valve. At this time, the blood pressure at one end of the second filter layer increases, driving the flow rate enhancement structure to operate, preventing blood reflux, and finally the filtered blood is returned to the patient's arterial or venous end.

[0014] As a preferred embodiment of the above technical solution, the mesenchymal cell component further comprises:

[0015] an inner tank connected to the outer shell and used for mounting the conical cover and the filter medium;

[0016] a guide hole, provided on the conical cover;

[0017] The arc tube is connected to the inner container and is arranged in a circle with the center point of the inner container as a reference.

[0018] As a preferred embodiment of the above technical solution, the liquid inlet end of the arc tube is close to the pressure relief valve and is located at one end of the filter medium, and the liquid outlet end of the arc tube is located in the middle of the outer side of the filter medium.

[0019] As a preferred embodiment of the above technical solution, the flow rate enhancement structure includes:

[0020] A connector connected to one end of the flow guide tube;

[0021] a conical head connected to the flow guide pipe through the connector;

[0022] an extruded metal strip connected to the connecting head through the tapered head;

[0023] A protective film is connected to the outer side of the extruded metal strip.

[0024] As a preferred embodiment of the above technical solution, the flow velocity enhancement structure further includes:

[0025] A connecting column, with both ends connected to the guide pipe and the connector, and the connecting column is arc-shaped;

[0026] The bending portion is connected to the connecting head, and the bending portion is in an arc shape.

[0027] As a preferred embodiment of the above technical solution, the shape of the extruded metal strip is arc-shaped, and both sides of the extruded metal strip are bent toward the middle.

[0028] As a preferred embodiment of the above technical solution, the filter layer is set to three layers, and the three filter layers are distributed in sequence along the axial direction of the conical cover, and the pore size of the three filter layers decreases step by step from the side away from the filter medium to the side close to the filter medium. The pressure relief valve and the guide tube are correspondingly arranged on the outside of each filter layer, and the opening pressure of the pressure relief valve increases step by step along the blood flow direction, and the adjacent two filter layers are connected through the guide tube.

[0029] As a preferred embodiment of the above technical solution, the extruded metal strip is made of shape memory alloy, and the protective film is made of medical-grade silicone.

[0030] As a preferred embodiment of the above technical solution, a chamber is provided inside the shell, and the inner liner and the arc-shaped tube are located inside the chamber.

[0031] The beneficial effects of the present invention are:

[0032] (1) Through the linkage design of three-layer filter layer and layer-by-layer pressure relief mechanism, dynamic adaptive switching of the filter path under the blocked state is realized. When the pressure of a certain filter layer increases due to blood cell blockage, the corresponding pressure relief valve automatically opens to guide the blood to the next filter layer, avoiding overload rupture of a single filter layer or interruption of blood flow. This layered pressure release and filtration relay mechanism can significantly extend the continuous operation time of the device and reduce the frequency of clinical membrane replacement. At the same time, by dispersing the pressure load layer by layer, the mechanical stress of a single component is reduced, the service life of the filter layer is increased and the operational risk is reduced;

[0033] (2) The flow rate enhancement structure design effectively solves the backflow risk of the traditional filtration system. The extruded metal strip automatically narrows the diameter of the guide tube under high pressure, increases the blood flow velocity through the Venturi effect, and forms a unidirectional flow trend to inhibit backflow; the arc tube guides part of the blood into the front and middle of the filter medium simultaneously, achieving multi-path uniform filtration and avoiding the decrease in filtration efficiency due to flow concentration in local areas. This design not only reduces the platelet adhesion rate and reduces the coagulation risk, but also reduces the blood shear force through laminar flow optimization, protects the integrity of blood cells, and significantly improves the safety of the ECMO system and the continuity of treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 The figure shows a schematic structural diagram of an extracorporeal membrane oxygenation device in combination with an ECMO and a mesenchymal cell filter in Example 1;

[0035] Figure 2 Shown is a cross-sectional view of the mesenchymal cell assembly in Example 1;

[0036] Figure 3 The figure shows the installation structure diagram of the arc tube in Example 1;

[0037] Figure 4 Shown is Figure 3 Schematic diagram of the structure of area A;

[0038] Figure 5 Shown is a schematic structural diagram of the extruded metal strip in Example 1.

[0039] In the figure: 1. Cart; 2. Gas mixer; 3. Blood pump; 4. Membrane separator; 5. Mesenchymal cell assembly; 51. Outer shell; 52. Inner liner; 53. Filter medium; 54. Conical cover; 55. Diversion hole; 56. Diversion tube; 57. Pressure relief valve; 58. Connector; 59. Connecting column; 510. Conical head; 511. Bend; 512. Extruded metal strip; 513. Protective membrane; 515. Filter layer; 516. Arc tube. DETAILED DESCRIPTION

[0040] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments.

[0041] Example 1

[0042] The present invention provides an extracorporeal membrane oxygenation device in combination with an ECMO and a mesenchymal cell filter, such as Figures 1 to 5As shown, the trolley 1 includes: a gas mixer 2, a blood pump 3, a membrane separator 4 and a mesenchymal cell assembly. The trolley 1 is used for transferring the extracorporeal membrane oxygenation device; the gas mixer 2 is arranged below the trolley 1; the blood pump 3 is arranged above the trolley 1; the membrane separator 4 is arranged outside the trolley 1; the mesenchymal cell assembly includes a shell 51, a filter medium 53, a cone cover 54, a guide tube 56, a pressure relief valve 57, a filter layer 515 and a flow rate enhancement structure; the cone cover 54 is connected to the trolley 1 through the shell 51, the filter layer 515 is connected to the cone cover 54, and the pressure relief valve 57 is connected to the filter layer 515 through the guide tube. The flow tube 56 is connected to the conical cover 54, and the flow rate enhancement structure is connected to the guide tube 56; the patient's venous blood is drawn out of the body through the blood pump 3, oxygenated in turn through the membrane separator 4, and then enters the mesenchymal cell component. At this time, it passes through the conical cover 54 to enter the outside of the filter layer 515. The number of filter layers 515 is set to three groups. By driving the pressure relief valve 57, it enters the second filter layer 515 along the guide tube 56. At this time, the blood pressure at one end of the second filter layer 515 increases to drive the flow rate enhancement structure to operate, preventing blood reflux, and finally returned to the patient's artery or vein after filtration.

[0043] Since the filter medium inside the mesenchymal cell assembly filters the blood, the accumulation of cells in the filter medium causes obstruction of blood flow, thereby increasing the blood flow resistance. Not only does it require the blood pump to provide greater power to maintain the blood flow rate, but the normal flow state of the blood may also be affected by local pressure changes. For this reason, through the cooperation of the conical cover 54, the guide tube 56 and the pressure relief valve 57, the gradually expanding conical channel inside the conical cover 54 guides the fluid distribution, and the three-layer filter layer 515 provides a gradient retention capacity. At this time, after the first filter layer 515 filters the blood, the cells in the blood accumulate at the liquid inlet end of the first filter layer 515, causing the blood flow rate on the surface of the first filter layer 515 to decrease, resulting in an increase in the blood pressure inside the conical cover 54 and the first filter layer 515, driving the pressure relief valve 57 to open, so that the blood enters the first filter layer 515 and the second filter layer 515 along the guide tube 56. According to the above process During the blood flow process, blood flows along the guide tube 56 into the space between the second filter layer 515 and the third filter layer 515. The three-layer pressure relief structure corresponds to the filter layer 515 one-to-one and is linked by the pressure relief valve 57, realizing dynamic switching of the filter path in the blocked state. The continuity of blood flow can be maintained without manual intervention, reducing downtime and adjustment time. The diversion effect of the pressure relief valve 57 can reduce the real-time load of the blocked layer, and actively divert the blood in the high-pressure area to avoid rupture of the filter layer 515 or blood reflux caused by local pressure exceeding the limit. The blood diverted to the next layer can continue to be processed by the downstream filter layer 515, so that the entire system can maintain a relatively stable total flow and filtration efficiency in the partially blocked state. In addition, the layered pressure relief design disperses the overall pressure load to the multi-layer structure, and reduces the mechanical stress of the individual components by gradually releasing the pressure peak, thereby extending the service life of the filter layer 515 and reducing the operational risks and costs caused by frequent replacement of the filter layer 515.

[0044] During use, the patient's venous blood is drawn out of the body through the blood pump 3, passes through the membrane separator 4 for oxygenation in turn, and then enters the mesenchymal cell assembly. At this time, it enters the outside of the first filter layer 515 through the conical cover 54 of the mesenchymal cell assembly. The blood is filtered on the outside of the first filter layer 515, so that cells in the blood remain on the outside of the first filter layer 515, resulting in an increase in blood pressure at one end of the first filter layer 515. At this time, the pressure drives the pressure relief valve 57 to open, causing the blood to pass through the pressure relief valve 57 and along the guide tube 56 into the second filter layer 515. At this time, the blood pressure at one end of the second filter layer 515 increases and drives The flow rate enhancement structure operates to increase the flow rate of the blood inside the guide tube 56, preventing the backflow of the decompressed blood. At this time, the blood is pretreated and then operates in sequence. The blood filtered along the third filter layer 515 enters the filter medium 53 and is filtered again by the filter medium 53. The filter medium 53 removes harmful substances (such as cytokines and inflammatory mediators) in the blood through the biological adsorption effect of mesenchymal stem cells (MSCs). The filtered blood is then returned to the patient's arterial or venous end, and at the same time, the external oxygen enters the membrane separator 4 along the gas mixer 2, so that the blood and gas are mixed.

[0045] Specifically, a gas mixer 2 is provided at the bottom of the cart 1, a blood pump 3 is provided at the top of the cart 1, a membrane separator 4 is suspended on the outside of the cart 1, and a mesenchymal cell assembly is provided in the middle of the cart 1. The mesenchymal cell assembly includes a shell 51, a conical cover 54 is provided inside the shell 51, and conical covers 54 are installed at both ends of the filter medium 53 inside the shell 51. A guide tube 56 is embedded in the conical cover 54 near the liquid inlet, and a pressure relief valve 57 is installed at one end of the guide tube 56 near the liquid inlet. A filter layer 515 is installed, and the filter layer 515 is arranged into three layers. The three filter layers 515 are sequentially distributed along the axial direction of the conical cover 54, and the apertures of the three filter layers 515 decrease step by step from the side away from the filter medium 53 to the side close to the filter medium 53. A pressure relief valve 57 and a guide tube 56 are provided on the outside of each filter layer 515, and the opening pressure of the pressure relief valve 57 increases step by step along the direction of blood flow. The two adjacent filter layers 515 are connected by the guide tube 56, and a flow rate enhancement structure is installed at one end of the guide tube 56.

[0046] In the present invention, the pressure relief valve 57 is a duckbill valve, the blood pump 3 is a centrifugal pump, and the filter medium 53 is a mesenchymal cell.

[0047] like Figures 2 to 5As shown, the flow rate enhancement structure includes: a connecting head 58, a connecting column 59, a conical head 510, a bending portion 511, an extruded metal strip 512 and a protective film 513; the connecting head 58 is connected to one end of the guide tube 56; the conical head 510 is connected to the guide tube 56 through the connecting head 58; the extruded metal strip 512 is connected to the connecting head 58 through the conical head 510; the protective film 513 is connected to the outside of the extruded metal strip 512; both ends of the connecting column 59 are connected to the guide tube 56 and the connecting head 58, and the shape of the connecting column 59 is arc-shaped; the bending portion 511 is connected to the connecting head 58, and the shape of the bending portion 511 is arc-shaped.

[0048] Since the blood flow rate of the first filter layer 515 is reduced after screening, the blood drives the pressure relief valve 57 to operate and enters between the first filter layer 515 and the second filter layer 515 along the guide tube 56. After the second filter layer 515 filters the blood, the cells in the blood cause the second filter layer 515 to be blocked, thereby reducing the blood flow rate inside the second filter layer 515, thereby increasing the pressure inside the second filter layer 515. At this time, the increased pressure is likely to cause the blood to flow back along the guide tube 56. For this reason, by providing the connecting head 58, the connecting column 59, the conical head 510, the bending part 511, the extruded metal strip 512 and the protective film 513, due to the design of the conical head 510, most of the blood enters the outside of the conical head 510, and a small part enters the conical head 5 10 outlet direction, and the conical design causes the outlet pressure of the conical head 510 to increase. At this time, when the pressure on the outside of the conical head 510 increases, the extruded metal strip 512 is driven to bend toward the inside of the conical head 510, reducing the flow diameter between the conical head 510 and the bent portion 511. At this time, the blood flow rate is increased by the smaller diameter. At this time, the blood flow rate is increased to prevent blood from flowing back. At the same time, the blood inside the second filter layer 515 drives the pressure relief valve 57 to run and enters between the second filter layer 515 and the third filter layer 515 along the guide tube 56, solving the problem that the traditional single filter structure is easy to clog and has a high risk of backflow. While ensuring the filtration efficiency, it improves the stability, safety and treatment continuity of the ECMO system. Then it runs in sequence, and finally, the blood enters the filter medium 53.

[0049] Specifically, the liquid outlet end of the guide tube 56 is connected to a connector 58, and a connecting column 59 is integrally formed inside the connector 58. The connecting columns 59 form a circular array with the center point of the guide tube 56, and a conical head 510 is welded between several connecting columns 59. The diameter of the conical head 510 close to the liquid outlet end of the guide tube 56 is smaller than the diameter of the other end. A plurality of extruded metal strips 512 are fixedly installed at one end of the conical head 510, and a bending portion 511 is connected between the plurality of extruded metal strips 512. The bending portion 511 is integrally formed with the connector 58. A protective film 513 is sleeved on the outer side of the plurality of extruded metal strips 512, and the protective film 513 is connected between the opposite surfaces of the bending portion 511 and the conical head 510. The shape of the extruded metal strip 512 is arc-shaped, and the two sides of the extruded metal strip 512 are bent toward the middle. The extruded metal strip 512 is made of shape memory alloy, and the protective film 513 is made of medical-grade silicone.

[0050] like Figure 2 and Figure 3 As shown, the mesenchymal cell assembly also includes: an inner liner 52, a guide hole 55 and an arc tube 516; the inner liner 52 is connected to the outer shell 51 for installing the conical cover 54 and the filter medium 53; the guide hole 55 is provided in the conical cover 54; the arc tube 516 is connected to the inner liner 52 and is arranged in a circle with the center point of the inner liner 52 as the reference.

[0051] In order to facilitate the installation of the conical cover 54 and the filter medium 53 and prevent the positions of the conical cover 54 and the filter medium 53 from being displaced, the conical cover 54 and the filter medium 53 are fixed by the inner liner 52 to prevent the positions of the conical cover 54 and the filter medium 53 from being displaced, and the arc tube 516 is used to make the blood be filtered synchronously along the front end and the middle end of the filter medium 53, thereby improving the filtering efficiency of the blood.

[0052] During use, the arc tube 516 and the inner liner 52 are installed. At this time, the blood at the liquid inlet flows along the inside of the conical cover 54 and enters the front end of the filter medium 53. At this time, under the action of the arc tube 516, part of the blood enters the middle part of the outer side of the filter medium 53 along the arc tube 516, and then is filtered synchronously along the front end and middle end of the filter medium 53. The filtered blood enters the inside of another conical cover 54. At this time, the blood is discharged along the conical cover 54 and the guide hole 55 of the conical cover 54.

[0053] Specifically, a chamber is opened inside the outer shell 51, and the inner liner 52 is fixedly installed inside the chamber of the outer shell 51. A guide hole 55 is opened inside the conical cover 54 between the two ends of the filter layer 515. An arc tube 516 is embedded in the outer side of the inner liner 52. The liquid inlet end of the arc tube 516 is close to the pressure relief valve 57 and is located at one end of the filter medium 53. The liquid outlet end of the arc tube 516 is located in the middle of the outer side of the filter medium 53.

[0054] Working principle: When the device is actually used, the device is moved to a pre-determined position by the cart 1, and then the device is used. When the device is in use, the patient's venous blood is drawn out of the body through the blood pump 3, passes through the membrane separator 4 in sequence for oxygenation, and then enters the mesenchymal cell component. The blood flows along the conical cover 54 and enters the outside of the first filter layer 515. The cells in the blood cause the first filter layer 515 to be blocked, which reduces the blood flow on the surface of the first filter layer 515, causing the blood pressure between the conical cover 54 and the first filter layer 515 to increase. The increased pressure drives the pressure relief valve 57 to open, causing the blood to flow along the guide tube 56 between the first filter layer 515 and the second filter layer 515. When the second filter layer 515 is blocked due to the cells in the filtered blood, the blood flow inside the filter layer 515 is reduced, which leads to an increase in the pressure between the first filter layer 515 and the second filter layer 515. At this time, the high pressure can easily cause the blood to flow back along the guide tube 56. The design of the conical head 510 allows most of the blood to enter the outside of the conical head 510, while a small part enters the outlet direction of the conical head 510. The conical design causes the outlet pressure of the conical head 510 to increase. At this time, when the pressure outside the conical head 510 increases, the extruded metal strip 512 is driven to bend inward of the conical head 510, thereby reducing the flow diameter between the conical head 510 and the bend 511. By narrowing the tube diameter, the blood flow rate is increased, effectively preventing backflow. At the same time, the high-pressure blood in the second filter layer 515 drives the pressure relief valve 57 to open, and flows along the guide tube 56 into the space between the second filter layer 515 and the third filter layer 515. This layer-by-layer pressure relief mechanism solves the problems of easy clogging and high backflow risk of traditional single filter structures. While ensuring filtration efficiency, the stability, safety and treatment continuity of the ECMO system are improved. The blood passes through multiple filter layers 515 in sequence and then enters the filter medium 53, thereby achieving the purpose of pre-treating the blood.

[0055] While the blood flows along the multiple filter layers 515 and enters the front end of the filter medium 53, the blood at the liquid inlet flows along the inside of the conical cover 54, and part of the blood enters the middle part of the outer side of the filter medium 53 through the arc tube 516, realizing synchronous filtration of the front end and the middle end of the filter medium 53. The filtered blood enters the conical cover 54 at the other end, is discharged along the guide hole 55 of the conical cover 54, and is finally returned to the patient's artery or vein. At the same time, the external oxygen enters the membrane separator 4 through the gas mixer 2 to realize gas-liquid mixing.

[0056] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same.

Claims

1. An extracorporeal membrane oxygenation device combined with ECMO and a mesenchymal cell filter, characterized in that: include: Cart (1), used for transporting the extracorporeal membrane oxygenation device; A gas mixer (2) is provided below the cart (1); A blood pump (3) is provided above the cart (1); A membrane separator (4) is arranged outside the cart (1); The mesenchymal cell assembly includes a housing (51), a filter medium (53), a conical cover (54), a flow guide tube (56), a pressure relief valve (57), a filter layer (515) and a flow rate enhancement structure; The conical cover (54) is connected to the cart (1) through the housing (51), the filter layer (515) is connected to the conical cover (54), the pressure relief valve (57) is connected to the conical cover (54) through the guide tube (56), and the flow rate enhancement structure is connected to the guide tube (56); The patient's venous blood is drawn out of the body through the blood pump (3), oxygenated in turn through the membrane separator (4), and then enters the mesenchymal cell assembly. At this time, it enters the outside of the filter layer (515) through the conical cover (54), and enters the second filter layer (515) along the guide tube (56) by driving the pressure relief valve (57). At this time, the blood pressure at one end of the second mesh filter layer (515) increases, driving the flow rate enhancement structure to operate, preventing blood reflux, and finally the filtered blood is returned to the patient's artery or vein.

2. The extracorporeal membrane oxygenation device according to claim 1, wherein: The mesenchymal cell component further comprises: An inner container (52) is connected to the outer shell (51) and is used for installing the conical cover (54) and the filter medium (53); A guide hole (55) is provided on the conical cover (54); The arc tube (516) is connected to the inner container (52) and is arranged in a circle with the center point of the inner container (52) as a reference.

3. The extracorporeal membrane oxygenation device according to claim 2, wherein: The liquid inlet end of the arc-shaped tube (516) is close to the pressure relief valve (57) and is located at one end of the filter medium (53), and the liquid outlet end of the arc-shaped tube (516) is located in the middle of the outer side of the filter medium (53).

4. The extracorporeal membrane oxygenation device according to claim 1, wherein: The flow rate enhancement structure comprises: A connector (58) connected to one end of the flow guide tube (56); A conical head (510) connected to the flow guide tube (56) via the connecting head (58); an extruded metal strip (512) connected to the connecting head (58) through the tapered head (510); A protective film (513) is connected to the outside of the extruded metal strip (512).

5. The extracorporeal membrane oxygenation device according to claim 4, wherein: The flow rate enhancement structure further comprises: A connecting column (59), with both ends connected to the guide tube (56) and the connecting head (58), and the connecting column (59) is in an arc shape; The bending portion (511) is connected to the connecting head (58), and the bending portion (511) is in an arc shape.

6. The extracorporeal membrane oxygenation device according to claim 4, wherein: The shape of the extruded metal strip (512) is arc-shaped, and both sides of the extruded metal strip (512) are bent toward the middle.

7. The extracorporeal membrane oxygenation device combined with an ECMO and a mesenchymal cell filter according to claim 3, characterized in that: The filter layer (515) is provided with three layers, and the three filter layers (515) are sequentially distributed along the axial direction of the conical cover (54), and the apertures of the three filter layers (515) decrease step by step from the side away from the filter medium (53) to the side close to the filter medium (53), and the pressure relief valve (57) and the guide tube (56) are correspondingly provided on the outside of each filter layer (515), and the opening pressure of the pressure relief valve (57) increases step by step along the blood flow direction, and two adjacent filter layers (515) are connected through the guide tube (56).

8. The extracorporeal membrane oxygenation device combined with ECMO and a mesenchymal cell filter according to claim 6, characterized in that: The extruded metal strip (512) is made of shape memory alloy, and the protective film (513) is made of medical-grade silicone.

9. The extracorporeal membrane oxygenation device combined with an ECMO and a mesenchymal cell filter according to claim 2, characterized in that: A chamber is provided inside the shell (51), and the inner container (52) and the arc-shaped tube (516) are located inside the chamber.

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