Peristaltic pump for liquid ultrafiltration and ultrafiltration process

Abstract

The invention relates to the technical field of ultrafiltration, in particular to a peristaltic pump for liquid ultrafiltration and an ultrafiltration process. The device comprises a supporting base, a movable plate, a mounting base, an overturning assembly, a rotation adjusting assembly and a supporting assembly. The device has the beneficial effects that the mounting seat is overturned through the overturning assembly, so that the curved surface of the mounting seat is far away from the supporting base, then the included angle between the movable plate and the supporting base is adjusted to be 90 degrees by rotating the adjusting assembly, and at the moment, the mounting seat can be mounted on curved surface equipment through the mounting hole; the adjusting assembly is rotated to adjust the included angle between the movable plate and the supporting base to be the inclination angle of to-be-installed slope equipment, the installation base can be installed on the slope equipment through the installation hole, it is guaranteed that the peristaltic pump body is in the horizontal working condition all the time, and the pump body is prevented from being deformed when installed on the curved surface / slope equipment; and the radial pressure imbalance of the roller on the hose under the non-horizontal working condition is prevented.

Description

Technical Field

[0001] The present invention relates to the technical field of ultrafiltration, in particular to a peristaltic pump for liquid ultrafiltration and an ultrafiltration process. Background Art

[0002] During the production of herpes zoster virus vaccine, the virus culture fluid needs to be concentrated and purified through a tangential flow ultrafiltration system. This process requires maintaining biological activity (activity retention rate ≥ 95%) and ensuring an absolutely sterile environment. Existing ultrafiltration devices often need to be installed on the side walls of biosafety cabinets and fermentation tanks.

[0003] However, it is necessary to arrange the peristaltic pump on the non-standard mounting surface (inclination ≤15° or curve radius ≥200mm) of the side wall of the biological safety cabinet or fermenter, and the standard base cannot fit the curved / inclined equipment (such as the safety cabinet guide plate with an inclination angle of 12°). The forced installation causes the pump body to deform by 0.5°-1.2°, and the radial pressure of the roller on the hose under non-horizontal working conditions is unbalanced, resulting in instantaneous flow fluctuations exceeding ±6% (the ultrafiltration process requires ≤±2%), which directly affects the integrity of the virus envelope and leads to a decrease in biological activity.

[0004] Therefore, it is necessary to provide a peristaltic pump for liquid ultrafiltration and an ultrafiltration process to solve the above problems.

[0005] It should be noted that the above information disclosed in this Background section is only for understanding the background technology of the present application concept, and therefore, it may contain information that does not constitute prior art. Summary of the Invention

[0006] Based on the above problems existing in the prior art, the problem to be solved by the present application is: to provide a peristaltic pump and ultrafiltration process for liquid ultrafiltration to achieve the effect of fitting curved / slanted surface installation.

[0007] The technical solution adopted by the present application to solve the technical problem is: a peristaltic pump for liquid ultrafiltration, comprising:

[0008] Peristaltic pump body;

[0009] A support base is fixed to the bottom of the peristaltic pump body;

[0010] There are two sets of movable plates, which are rotatably arranged on both sides of the supporting base;

[0011] The mounting base is provided between the two sets of movable plates, and one side of the mounting base is flat and the other side is curved. The mounting base is provided with multiple sets of mounting holes for mounting on an inclined surface or a curved surface, and a handle is also provided on the mounting base;

[0012] A flip assembly is provided in the movable plate and is used for flipping the mounting seat;

[0013] A rotation adjustment component is provided in the movable plate and is used to adjust the angle between the movable plate and the support base;

[0014] The support assembly is arranged between the movable plate and the support base and is used for supporting the support base.

[0015] Preferably, the flip assembly includes an adjustment slot, which is provided on a side of the movable plate close to the mounting seat, an adjustment block is slidably provided in the adjustment slot, a rotation slot is provided on a side of the adjustment block close to the mounting seat, a second rotation shaft is provided at a position of the mounting seat corresponding to the rotation slot, and the second rotation shaft is in the adjustment slot;

[0016] The flip assembly also includes a positioning piece for limiting the position of the mounting seat after flipping.

[0017] Preferably, a first limit groove is provided on the adjustment block, the first limit groove passes through the adjustment block, a second limit groove is provided at the position of the second rotating shaft corresponding to the first limit groove, a limit column is provided at the top of the adjustment groove at the position corresponding to the first limit groove, the limit column passes through the first limit groove and the second limit groove, and when the adjustment block is located at the bottom of the adjustment groove, the limit column is separated from the second limit groove.

[0018] Preferably, a block top groove is provided on the side of the adjustment block away from the mounting seat. When the adjustment block is located at the top or bottom of the adjustment groove, a card slot is provided at the position of the adjustment groove corresponding to the card block top groove. The card slot is a truncated cone structure. A card block is slidably arranged in the card block top groove. The end of the card block close to the card slot is a truncated cone structure. A first spring is connected between the card block and the card block top groove for pushing the card block into the card slot.

[0019] Preferably, the positioning member includes a first positioning groove, the first positioning groove is provided on a side of the mounting seat away from the support base, a positioning column is provided at a position of the mounting seat corresponding to the first positioning groove, a first gear top groove is provided in the movable plate, the first gear top groove is communicated with the first positioning groove, a first gear block is slidably provided in the first gear top groove, and a third spring is connected between the first gear block and the first gear top groove for pushing the first gear block into the first positioning groove;

[0020] The first positioning groove and the positioning column are both arc-shaped structures, and the centers of the first positioning groove and the positioning column coincide with the center of the second rotating shaft. A first gear inclined surface is provided on the side of the first gear block away from the support base.

[0021] Preferably, the positioning member also includes a second positioning groove, the second positioning groove is opened at the bottom of the movable plate, a second gear top groove is opened in the movable plate, the second gear top groove is connected to the second positioning groove, a second gear block is slidably arranged in the second gear top groove, a fourth spring is connected between the second gear top groove and the second gear block, used to push the second gear block into the second positioning groove, and a second gear inclined surface is opened at the bottom of the second gear block.

[0022] Preferably, the rotation adjustment component includes an adjustment through hole, the adjustment through hole is provided on the movable plate, a first rotating shaft is provided at a position of the support base corresponding to the adjustment through hole, the first rotating shaft is rotatably provided in the adjustment through hole, a limiting slide groove is provided in the movable plate, and the limiting slide groove is communicated with the adjustment through hole;

[0023] A rotation limit groove is provided on the circumference at the position of the corresponding limit groove of the first rotating shaft, a limit slider is slidingly provided in the limit groove, a rotation limit block is provided at the position of the limit slider corresponding to the rotation limit groove, and a second spring is connected between the limit slider and the limit groove for pushing the limit groove to move toward the direction of the first rotating shaft.

[0024] Preferably, a pressing groove is provided on the top of the movable plate, the pressing groove is connected to the limiting slide groove, a pressing block is slidably provided in the pressing groove, a pressing inclined surface is provided on the bottom of the pressing block, a holding groove is provided on the limiting slider, the holding groove passes through the limiting slider, a guide groove is provided on one side of the pressing groove, a guide block is provided at the position of the pressing block corresponding to the guide groove, and the guide block is slidably provided in the guide groove;

[0025] A traction groove is provided on the side of the pressing block away from the guide block, and a traction rope is connected to the traction groove. Two branch ropes are provided at the other end of the traction rope. Each branch rope passes through the bottom of the first gear top groove and the second gear top groove respectively and is connected to the first gear block and the second gear block respectively.

[0026] Preferably, the support assembly includes a support connecting block, which is arranged on both sides of the support base, and a plurality of support slots are provided at the bottom of the support connecting block. A storage slot is provided on the side of the movable plate close to the support connecting block, and a support plate is rotatably provided on the top of the storage slot. The support plate is used to extend into the support slot, and a through hole is provided in the support slot. The through hole passes through the support connecting block, the support base and the support plate. When the support plate extends into the support slot, it is fixed by passing a support pin through the support plate.

[0027] A liquid ultrafiltration process is also proposed, which is carried out using the above-mentioned device and comprises:

[0028] Pretreatment stage: deep filtration is used to remove cell debris and large particle impurities, retain virus particles, and quantitative addition of buffer is performed through a multi-channel peristaltic pump to ensure the stability of subsequent ultrafiltration;

[0029] Tangential flow ultrafiltration: Using hollow fiber membrane, a high-flow peristaltic pump and a transmembrane pressure sensor are linked to drive the ultrafiltration circuit and dynamically adjust the speed;

[0030] Dialysis replacement: Through the dual-pump linkage system, fluid infusion and drainage are controlled separately, and the fluid infusion rate = drainage rate ±% tolerance;

[0031] Stabilizer addition: Stabilizer is added via a micro peristaltic pump.

[0032] The beneficial effects of the present application are: a peristaltic pump and ultrafiltration process for liquid ultrafiltration provided by the present application, wherein the mounting seat is flipped by a flipping assembly so that the curved surface of the mounting seat is away from the support base, and then the angle between the movable plate and the support base is adjusted to ninety degrees by rotating the adjustment assembly. At this time, the mounting seat can be installed on the curved surface device through the mounting hole, and the support base is supported by the support assembly. At this time, the peristaltic pump body is placed horizontally, and the mounting seat is flipped by the flipping assembly so that the plane of the mounting seat is away from the support base. At this time, the angle between the movable plate and the support base is adjusted to the inclination angle of the inclined surface device to be installed by rotating the adjustment assembly. At this time, the peristaltic pump body is placed horizontally, and then the support base is supported by the support assembly, so that it can be installed in accordance with the curved surface / inclined surface device, and the peristaltic pump body is always in a horizontal working condition, thereby preventing the pump body from being deformed when installed on the curved surface / inclined surface device, preventing the roller from exerting uneven radial pressure on the hose under non-horizontal working conditions, ensuring the stability of instantaneous flow fluctuations, and thereby ensuring the integrity of the viral envelope and preventing the decline of biological activity.

[0033] In addition to the above-described purposes, features and advantages, the present application also has other purposes, features and advantages. The present application will be further described in detail below with reference to the drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention;

[0035] Figure 2 It is a schematic cross-sectional view of the present invention;

[0036] Figure 3 for Figure 2 A magnified schematic diagram of the structure at point A;

[0037] Figure 4 It is a schematic cross-sectional view of the supporting connecting block and the movable plate of the present invention;

[0038] Figure 5 for Figure 4 A magnified schematic diagram of the structure at B;

[0039] Figure 6 It is a schematic cross-sectional structural diagram of the movable plate of the present invention;

[0040] Figure 7 for Figure 6 An enlarged schematic diagram of the structure at C;

[0041] Figure 8 for Figure 6 A magnified schematic diagram of the structure at position D;

[0042] Figure 9 A schematic diagram of the three-dimensional structure of the mounting base of the present invention;

[0043] Figure 10 It is a schematic diagram of the three-dimensional structure of the first rotating shaft, the pressing block and the limiting sliding block of the present invention.

[0044] In the figure: 1. Peristaltic pump body; 2. Support base; 3. Mounting seat; 4. Mounting hole; 5. Handle; 6. Support connecting block; 7. Through hole; 8. Support plate; 9. Movable plate; 10. First rotating shaft; 11. Pressing block; 12. First positioning slot; 13. Adjusting slot; 14. Limiting column; 15. Adjusting block; 1501, First limiting slot; 1502, Rotating slot; 16. Second rotating shaft; 1601, Second limiting slot; 17. Slot; 18. Block; 19. Block top slot; 20. First spring; 21. Second positioning slot; 22. Supporting slot; 23 , support pin; 24, storage slot; 25, positioning column; 26, first gear block; 2601, first gear inclined surface; 27, adjustment through hole; 29, rotation limit slot; 30, limit slide slot; 31, second spring; 32, limit slider; 3201, support slot; 33, rotation limit block; 34, guide slot; 35, guide block; 36, traction slot; 37, pressing slot; 38, traction rope; 39, first gear top slot; 40, third spring; 41, second gear top slot; 42, fourth spring; 43, second gear block; 4301, second gear inclined surface. DETAILED DESCRIPTION

[0045] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments in this application can be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0046] like Figures 1-10 As shown, the present application provides a peristaltic pump for liquid ultrafiltration, comprising: a peristaltic pump body 1; a support base 2, fixed to the bottom of the peristaltic pump body 1; two groups of movable plates 9, rotatably arranged on both sides of the support base 2; a mounting seat 3, arranged between the two groups of movable plates 9, and one side of which is a flat surface and the other side is a curved surface, and a plurality of groups of mounting holes 4 are provided on the mounting seat 3 for installation on an inclined surface or a curved surface, and a handle 5 is also provided on the mounting seat 3; a flip assembly, arranged in the movable plate 9, for flipping the mounting seat 3; a rotation adjustment assembly, arranged in the movable plate 9, for adjusting the angle between the movable plate 9 and the support base 2; a support assembly, arranged between the movable plate 9 and the support base 2, for supporting the support base 2.

[0047] The mounting base 3 is flipped by the flipping assembly so that the curved surface of the mounting base 3 is away from the support base 2, and then the angle between the movable plate 9 and the support base 2 is adjusted to ninety degrees by rotating the adjusting assembly. At this time, the mounting base 3 can be installed on the curved surface device through the mounting hole 4, and the support base 2 is supported by the supporting assembly. At this time, the peristaltic pump body 1 is placed horizontally, and the mounting base 3 is flipped by the flipping assembly so that the plane of the mounting base 3 is away from the support base 2. At this time, the angle between the movable plate 9 and the support base 2 is adjusted to the inclination angle of the inclined surface device to be installed by rotating the adjusting assembly. At this time, the peristaltic pump body 1 is placed horizontally, and then the support base 2 is supported by the supporting assembly, so that it can be installed in accordance with the curved surface / inclined surface device, and the peristaltic pump body 1 is always in a horizontal working condition to prevent the pump body from being deformed when installed on the curved surface / inclined surface device, and to prevent the radial pressure of the roller on the hose from being uneven under non-horizontal working conditions, thereby ensuring the stability of instantaneous flow fluctuations, and thus ensuring the integrity of the virus envelope and preventing the decline of biological activity.

[0048] Specifically, such as Figure 2-Figure 3 As shown, the flip assembly includes an adjustment groove 13, which is opened on the side of the movable plate 9 close to the mounting seat 3. An adjustment block 15 is slidably arranged in the adjustment groove 13, and a rotation groove 1502 is opened on the side of the adjustment block 15 close to the mounting seat 3. A second rotation shaft 16 is provided at the position of the corresponding rotation groove 1502 of the mounting seat 3, and the second rotation shaft 16 is in the adjustment groove 13; the flip assembly also includes a positioning member for limiting the mounting seat 3 after flipping.

[0049] The mounting seat 3 can drive the adjusting block 15 to slide in the adjusting slot 13 via the second rotating shaft 16 .

[0050] Specifically, such as Figure 3 As shown, a first limiting groove 1501 is provided on the adjusting block 15, and the first limiting groove 1501 passes through the adjusting block 15. A second limiting groove 1601 is provided at the position of the second rotating shaft 16 corresponding to the first limiting groove 1501. A limiting column 14 is provided at the top of the adjusting groove 13 at the position corresponding to the first limiting groove 1501. The limiting column 14 passes through the first limiting groove 1501 and the second limiting groove 1601. When the adjusting block 15 is located at the bottom of the adjusting groove 13, the limiting column 14 is separated from the second limiting groove 1601.

[0051] The limiting column 14 limits the rotation of the second rotating shaft 16. When the adjustment block 15 slides to the bottom of the adjustment slot 13, the limiting column 14 is separated from the second rotating shaft 16, and the rotation limit of the second rotating shaft 16 is cancelled. At this time, the mounting base 3 can be flipped.

[0052] Specifically, such as Figure 3As shown, a block top groove 19 is provided on the side of the adjustment block 15 away from the mounting seat 3. When the adjustment block 15 is located at the top or bottom of the adjustment slot 13, a slot 17 is provided at the position of the adjustment slot 13 corresponding to the block top groove 19. The slot 17 is a truncated cone structure. A block 18 is slidably provided in the block top groove 19. The end of the block 18 close to the slot 17 is a truncated cone structure. A first spring 20 is connected between the block 18 and the block top groove 19 for pushing the block 18 into the slot 17.

[0053] When the adjusting block 15 is located at the top or bottom of the adjusting slot 13 , the first spring 20 pushes the locking block 18 into the locking slot 17 to lock the adjusting block 15 in place.

[0054] Specifically, such as Figure 7 As shown, the positioning member includes a first positioning groove 12, which is provided on a side of the mounting seat 3 away from the support base 2, and a positioning column 25 is provided at the position of the mounting seat 3 corresponding to the first positioning groove 12. A first gear top groove 39 is provided in the movable plate 9, and the first gear top groove 39 is connected to the first positioning groove 12. A first gear block 26 is slidingly provided in the first gear top groove 39, and a third spring 40 is connected between the first gear block 26 and the first gear top groove 39 for pushing the first gear block 26 into the first positioning groove 12; the first positioning groove 12 and the positioning column 25 are both arc-shaped structures, and the center of the first positioning groove 12 and the positioning column 25 coincide with the center of the second rotating shaft 16, and the first gear inclined surface 2601 is provided on the side of the first gear block 26 away from the support base 2.

[0055] When the mounting base 3 is flipped, the positioning column 25 is driven to rotate, and the positioning column 25 enters the first positioning groove 12. After the positioning column 25 contacts the first gear inclined surface 2601, it squeezes the first gear block 26, and presses the first gear block 26 into the first gear top groove 39 until the positioning column 25 passes through the first gear block 26. The third spring 40 pushes the first gear block 26 into the first positioning groove 12, thereby limiting the positioning column 25.

[0056] Specifically, such as Figure 8 As shown, the positioning member also includes a second positioning groove 21, the second positioning groove 21 is opened at the bottom of the movable plate 9, and a second gear top groove 41 is opened in the movable plate 9. The second gear top groove 41 is connected to the second positioning groove 21, and a second gear block 43 is slidingly arranged in the second gear top groove 41. A fourth spring 42 is connected between the second gear top groove 41 and the second gear block 43, which is used to push the second gear block 43 into the second positioning groove 21, and a second gear inclined surface 4301 is opened at the bottom of the second gear block 43.

[0057] When the mounting seat 3 moves, it drives the positioning column 25 to enter the second positioning groove 21. After the positioning column 25 contacts the second gear inclined surface 4301, it squeezes the second gear block 43 and presses the second gear block 43 into the second gear top groove 41 until the positioning column 25 passes through the second gear block 43. The fourth spring 42 pushes the second gear block 43 into the second positioning groove 21, thereby limiting the positioning column 25.

[0058] Specifically, such as Figure 4-Figure 5 As shown, the rotation adjustment component includes an adjustment through hole 27, which is provided on the movable plate 9. A first rotating shaft 10 is provided at the position of the corresponding adjustment through hole 27 of the support base 2. The first rotating shaft 10 is rotatably provided in the adjustment through hole 27. A limiting slide 30 is provided in the movable plate 9, and the limiting slide 30 is communicated with the adjustment through hole 27; a rotation limiting groove 29 is provided on the circumference of the position of the first rotating shaft 10 corresponding to the limiting slide 30, and a limiting slider 32 is provided slidingly in the limiting slide 30. A rotation limiting block 33 is provided at the position of the limiting slider 32 corresponding to the rotation limiting groove 29. A second spring 31 is connected between the limiting slider 32 and the limiting slide 30 for pushing the limiting slide 30 to move toward the direction of the first rotating shaft 10; a pressing groove is provided on the top of the movable plate 9 37. The pressing groove 37 is connected to the limiting slide groove 30. A pressing block 11 is slidingly arranged in the pressing groove 37. A pressing inclined surface is provided at the bottom of the pressing block 11. A supporting groove 3201 is provided on the limiting slider 32. The supporting groove 3201 passes through the limiting slider 32. A guide groove 34 is provided on one side of the pressing groove 37. A guide block 35 is provided at the position of the pressing block 11 corresponding to the guide groove 34. The guide block 35 is slidably arranged in the guide groove 34; a traction groove 36 is provided on the side of the pressing block 11 away from the guide block 35. A traction rope 38 is connected to the traction groove 36. Two branch ropes are provided at the other end of the traction rope 38. Each branch rope passes through the bottom of the first gear top groove 39 and the second gear top groove 41 respectively and is connected to the first gear block 26 and the second gear block 43 respectively.

[0059] By pressing the pressing block 11, the pressing block 11 moves downward, and the pressing inclined surface at the bottom of the pressing block 11 cooperates with the supporting groove 3201, thereby driving the limit slider 32 to move toward the second spring 31. At this time, the rotation limit block 33 on the limit slider 32 is separated from the rotation limit groove 29, and the rotation limit of the movable plate 9 is cancelled. The pressing block 11 moves downward to tighten the traction rope 38, and then drives the second gear block 43 to be retracted into the second gear top groove 41 or drives the first gear block 26 to be retracted into the first gear top groove 39. The guide groove 34 cooperates with the guide block 35 to guide the pressing block 11, and the traction rope 38 is retracted into the traction groove 36. At this time, the limit on the positioning column 25 is cancelled.

[0060] Specifically, such as Figure 4As shown, the support assembly includes a support block 6, which is arranged on both sides of the support base 2. A plurality of support slots 22 are provided at the bottom of the support block 6. A storage slot 24 is provided on the side of the movable plate 9 close to the support block 6. A support plate 8 is rotatably provided on the top of the storage slot 24. The support plate 8 is used to extend into the support slot 22. A through hole 7 is provided in the support slot 22. The through hole 7 passes through the support block 6, the support base 2 and the support plate 8. When the support plate 8 extends into the support slot 22, it is fixed by passing the support pin 23 through the support plate 8.

[0061] Take out the support plate 8 in the storage slot 24, rotate the movable plate 9, and then insert the support plate 8 into the corresponding support slot 22. Then, pass the support pin 23 through the support base 2 and the two groups of support plates 8 to connect the two groups of support plates 8 into one, so that the two groups of movable plates 9 and support plates 8 cooperate to support the support base 2 at the same time, ensuring the stability of the support.

[0062] A liquid ultrafiltration process is also proposed, which is carried out using the above-mentioned device and comprises:

[0063] Pretreatment stage: deep filtration is used to remove cell debris and large particle impurities, retain virus particles, and quantitative addition of buffer is performed through a multi-channel peristaltic pump to ensure the stability of subsequent ultrafiltration;

[0064] Tangential flow ultrafiltration: Using hollow fiber membrane, a high-flow peristaltic pump and a transmembrane pressure sensor are linked to drive the ultrafiltration circuit and dynamically adjust the speed;

[0065] Dialysis replacement: Through the dual-pump linkage system, fluid infusion and drainage are controlled separately, and the fluid infusion rate = drainage rate ± 3% tolerance;

[0066] Stabilizer addition: Stabilizer is added via a micro peristaltic pump.

[0067] The specific plan is:

[0068] First, adjust the angle between the support base 2 and the mounting seat 3 to adapt to the inclined surface or curved surface. By pressing the pressing block 11, the pressing block 11 moves downward, and the pressing inclined surface at the bottom of the pressing block 11 cooperates with the abutting groove 3201, thereby driving the limiting slider 32 to move toward the second spring 31. At this time, the rotation limit block 33 on the limiting slider 32 is separated from the rotation limit groove 29, and the rotation limit of the movable plate 9 is cancelled. At this time, take out the support plate 8 in the storage groove 24, and then rotate the movable plate 9. If it is installed on a slope, adjust the angle between the movable plate 9 and the support base 2 to be the same as the inclination angle of the slope. If it is installed on a curved surface, Adjust the angle between the movable plate 9 and the support base 2 to ninety degrees, and at the same time insert the support plate 8 into the corresponding support slot 22, and then pass the support pin 23 through the support base 2 and the two groups of support plates 8 to connect the two groups of support plates 8 into one, so that the two groups of movable plates 9 and the support plates 8 cooperate to support the support base 2 at the same time, ensuring the stability of the support and the level of the support base 2 and the peristaltic pump body 1. After the adjustment is completed, the pressing block 11 is reset. At this time, the second spring 31 pushes the limit slider 32 toward the first rotating shaft 10, so that the rotation limit block 33 cooperates with the rotation limit groove 29 to limit the rotation of the movable plate 9.

[0069] When the mounting surface of the mounting seat 3 changes from an inclined surface to a curved surface, the pressing block 11 is first pressed. At this time, the pressing block 11 moves downward to drive the traction rope 38 to be tightened, and then the second gear block 43 is driven to be received in the second gear top groove 41. The guide groove 34 cooperates with the guide block 35 to guide the pressing block 11, and the traction rope 38 is received in the traction groove 36. At this time, the limit on the positioning column 25 is cancelled, and then the mounting seat 3 is pulled downward by the handle 5. The positioning column 25 on the mounting seat 3 is disengaged from the second positioning groove 21, and the mounting seat 3 drives the adjusting block 15 to slide from top to bottom in the adjusting groove 13 through the second rotating shaft 16. The limiting column 14 limits the rotation of the second rotating shaft 16 until the adjusting block 15 slides to the bottom of the adjusting groove 13. At this time, the first spring 20 pushes the card block 18 into the card slot 17 to adjust When the cam 14 is in engagement with the first stop 15, the stop block 15 is locked and the limit column 14 is separated from the second rotating shaft 16. At this time, the pressing block 11 is released, and the fourth spring 42 pushes the second stop block 43 to reset, and then drives the pressing block 11 to reset through the traction rope 38. Then, the mounting seat 3 can drive the mounting seat 3 to rotate one hundred and eighty degrees through the handle 5. When the mounting seat 3 is flipped, the positioning column 25 is driven to rotate, and the positioning column 25 enters the first positioning groove 12. After the positioning column 25 contacts the first stop inclined surface 2601, it squeezes the first stop block 26 and presses the first stop block 26 into the first stop top groove 39 until the positioning column 25 passes through the first stop block 26. The third spring 40 pushes the first stop block 26 to enter the first positioning groove 12, and then limits the positioning column 25, completing the transformation of the mounting surface of the mounting seat 3 from an inclined surface to a curved surface.

[0070] When the mounting surface of the mounting seat 3 changes from a curved surface to an inclined surface, the pressing block 11 is first pressed. At this time, the pressing block 11 moves downward to drive the traction rope 38 to tighten, and then drives the first gear block 26 to be received in the first gear top groove 39. The guide groove 34 cooperates with the guide block 35 to guide the pressing block 11, and the traction rope 38 is received in the traction groove 36. At this time, the limit on the positioning column 25 is cancelled, and then the mounting seat 3 is turned outward 180 degrees by the handle 5. The positioning column 25 on the mounting seat 3 is disengaged from the first positioning groove 12. At this time, the pressing block 11 will be released, and the third spring 40 pushes the first gear block 26 to reset, and then the pressing block 11 is reset by the traction rope 38. At this time, the mounting seat 3 is pushed upward by the handle 5, and the mounting seat 3 is passed. The second rotating shaft 16 drives the adjusting block 15 from bottom to top in the adjusting groove 13, and the limiting column 14 limits the rotation of the second rotating shaft 16 until the adjusting block 15 slides to the top of the adjusting groove 13. At this time, the first spring 20 pushes the blocking block 18 into the blocking slot 17 to block the adjusting block 15. When moving, the mounting seat 3 drives the positioning column 25 into the second positioning groove 21. After the positioning column 25 contacts the second gear inclined surface 4301, it squeezes the second gear block 43 and presses the second gear block 43 into the second gear top groove 41 until the positioning column 25 passes through the second gear block 43. The fourth spring 42 pushes the second gear block 43 into the second positioning groove 21, thereby limiting the positioning column 25, completing the transformation of the mounting surface of the mounting seat 3 from a curved surface to an inclined surface.

[0071] It should be understood by those skilled in the art that the discussion of any of the above embodiments is merely illustrative and is not intended to imply that the scope of the present invention (including the claims) is limited to these examples. Within the scope of the present invention, the technical features in the above embodiments or different embodiments may be combined, the steps may be implemented in any order, and there are many other variations of the different aspects of the present invention as described above, which are not provided in detail for the sake of simplicity.

[0072] The present invention is intended to cover all such substitutions, modifications and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A peristaltic pump for liquid ultrafiltration, characterized in that: include: Peristaltic pump body (1); A support base (2) fixed to the bottom of the peristaltic pump body (1); Two sets of movable plates (9) are provided and are rotatably arranged on both sides of the support base (2); A mounting seat (3) is provided between the two sets of movable plates (9), and one side of the mounting seat is a flat surface and the other side is a curved surface. The mounting seat (3) is provided with a plurality of mounting holes (4) for mounting on an inclined surface or a curved surface. The mounting seat (3) is also provided with a handle (5); A flip assembly, disposed in the movable plate (9), and used for flipping the mounting seat (3); A rotation adjustment component is provided in the movable plate (9) and is used to adjust the angle between the movable plate (9) and the support base (2); A support assembly is provided between the movable plate (9) and the support base (2), and is used to support the support base (2).

2. A peristaltic pump for liquid ultrafiltration according to claim 1, characterized in that: The flip assembly includes an adjustment groove (13), the adjustment groove (13) is provided on a side of the movable plate (9) close to the mounting seat (3), an adjustment block (15) is slidably provided in the adjustment groove (13), a rotation groove (1502) is provided on a side of the adjustment block (15) close to the mounting seat (3), a second rotation shaft (16) is provided at a position of the mounting seat (3) corresponding to the rotation groove (1502), and the second rotation shaft (16) is in the adjustment groove (13); The flip assembly further comprises a positioning member for limiting the position of the mounting seat (3) after flipping.

3. A peristaltic pump for liquid ultrafiltration according to claim 2, characterized in that: A first limiting groove (1501) is provided on the adjusting block (15), and the first limiting groove (1501) passes through the adjusting block (15); a second limiting groove (1601) is provided on the second rotating shaft (16) at a position corresponding to the first limiting groove (1501); a limiting column (14) is provided at a position corresponding to the first limiting groove (1501) on the top of the adjusting groove (13), and the limiting column (14) passes through the first limiting groove (1501) and the second limiting groove (1601); when the adjusting block (15) is located at the bottom of the adjusting groove (13), the limiting column (14) is separated from the second limiting groove (1601).

4. A peristaltic pump for liquid ultrafiltration according to claim 3, characterized in that: A card block top groove (19) is provided on a side of the adjustment block (15) away from the mounting seat (3). When the adjustment block (15) is located at the top or bottom of the adjustment groove (13), a card slot (17) is provided at a position of the adjustment groove (13) corresponding to the card block top groove (19). The card slot (17) is a truncated cone structure. A card block (18) is slidably provided in the card block top groove (19). The end of the card block (18) close to the card slot (17) is a truncated cone structure. A first spring (20) is connected between the card block (18) and the card block top groove (19) for pushing the card block (18) into the card slot (17).

5. A peristaltic pump for liquid ultrafiltration according to claim 2, characterized in that: The positioning member includes a first positioning groove (12), the first positioning groove (12) is provided on a side of the mounting seat (3) away from the support base (2), the mounting seat (3) is provided with a positioning column (25) at a position corresponding to the first positioning groove (12), a first gear top groove (39) is provided in the movable plate (9), the first gear top groove (39) is communicated with the first positioning groove (12), a first gear block (26) is slidably provided in the first gear top groove (39), and a third spring (40) is connected between the first gear block (26) and the first gear top groove (39) for pushing the first gear block (26) into the first positioning groove (12); The first positioning groove (12) and the positioning column (25) are both arc-shaped structures, and the center of the first positioning groove (12) and the positioning column (25) coincides with the center of the second rotating shaft (16). A first gear inclined surface (2601) is provided on a side of the first gear block (26) away from the support base (2).

6. A peristaltic pump for liquid ultrafiltration according to claim 5, characterized in that: The positioning member further comprises a second positioning groove (21), the second positioning groove (21) being provided at the bottom of the movable plate (9), a second gear top groove (41) being provided in the movable plate (9), the second gear top groove (41) being communicated with the second positioning groove (21), a second gear block (43) being slidably provided in the second gear top groove (41), a fourth spring (42) being connected between the second gear top groove (41) and the second gear block (43) for pushing the second gear block (43) into the second positioning groove (21), and a second gear inclined surface (4301) being provided at the bottom of the second gear block (43).

7. A peristaltic pump for liquid ultrafiltration according to claim 6, characterized in that: The rotation adjustment component includes an adjustment through hole (27), the adjustment through hole (27) is provided on the movable plate (9), a first rotating shaft (10) is provided at a position corresponding to the adjustment through hole (27) of the support base (2), the first rotating shaft (10) is rotatably provided in the adjustment through hole (27), a limiting sliding groove (30) is provided in the movable plate (9), and the limiting sliding groove (30) is communicated with the adjustment through hole (27); A rotation limiting groove (29) is provided on the circumference of the first rotating shaft (10) at a position corresponding to the limiting slide groove (30); a limiting slider (32) is slidably provided in the limiting slide groove (30); a rotation limiting block (33) is provided at a position corresponding to the rotation limiting groove (29) of the limiting slider (32); a second spring (31) is connected between the limiting slider (32) and the limiting slide groove (30) for pushing the limiting slide groove (30) to move toward the first rotating shaft (10).

8. A peristaltic pump for liquid ultrafiltration according to claim 7, characterized in that: A pressing groove (37) is provided on the top of the movable plate (9), the pressing groove (37) is communicated with the limiting sliding groove (30), a pressing block (11) is slidably provided in the pressing groove (37), a pressing inclined surface is provided on the bottom of the pressing block (11), a supporting groove (3201) is provided on the limiting sliding block (32), the supporting groove (3201) passes through the limiting sliding block (32), a guide groove (34) is provided on one side of the pressing groove (37), a guide block (35) is provided at a position of the pressing block (11) corresponding to the guide groove (34), and the guide block (35) is slidably provided in the guide groove (34); A traction groove (36) is provided on a side of the pressing block (11) away from the guide block (35), a traction rope (38) is connected to the traction groove (36), and two branch ropes are provided at the other end of the traction rope (38), each branch rope respectively passing through the bottom of the first gear top groove (39) and the second gear top groove (41) and connected to the first gear block (26) and the second gear block (43).

9. A peristaltic pump for liquid ultrafiltration according to claim 1, characterized in that: The support assembly includes a support block (6), the support block (6) is arranged on both sides of the support base (2), a plurality of support slots (22) are provided at the bottom of the support block (6), a storage slot (24) is provided on the side of the movable plate (9) close to the support block (6), a support plate (8) is rotatably provided at the top of the storage slot (24), the support plate (8) is used to extend into the support slot (22), a through hole (7) is provided in the support slot (22), the through hole (7) passes through the support block (6), the support base (2) and the support plate (8), and when the support plate (8) extends into the support slot (22), it is fixed by a support pin (23) passing through the support plate (8).

10. A liquid ultrafiltration process, using a peristaltic pump for ultrafiltration of herpes zoster virus liquid according to any one of claims 1 to 9, the process comprising the following steps: Pretreatment stage: deep filtration is used to remove cell debris and large particle impurities, retain virus particles, and quantitative addition of buffer is performed through a multi-channel peristaltic pump to ensure the stability of subsequent ultrafiltration; Tangential flow ultrafiltration: Using hollow fiber membrane, a high-flow peristaltic pump and a transmembrane pressure sensor are linked to drive the ultrafiltration circuit and dynamically adjust the speed; Dialysis replacement: Through the dual-pump linkage system, fluid infusion and drainage are controlled separately, and the fluid infusion rate = drainage rate ± 3% tolerance; Stabilizer addition: Stabilizer is added via a micro peristaltic pump.

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