Traditional Chinese medicine granules for treating liver cancer and preparation method thereof

Abstract

The invention discloses traditional Chinese medicine granules for treating liver cancer and a preparation method thereof, and relates to the technical field of traditional Chinese medicine formulas. The traditional Chinese medicine granules for treating liver cancer are prepared from aged black nightshade, marsdenia tenacissima, podophyllum, thunberg fritillary bulb, sculellaria barbata, oldenlandia diffusa, lucid ganoderma, phellinus igniarius, polygonum cuspidatum, sedum sarmentosum, lysimachia christinae hance, hypericum japonicum, dandelion, roasted turtle shell, astragalus membranaceus, ginger processed pinellia, scorpio and reed rhizome. The traditional Chinese medicine composition is composed of sargentgloryvine stem, patrinia heterophylla, codonopsis pilosula, Chinese yam, bighead atractylodes rhizome, fried endothelium corneum gigeriae galli, curcuma zedoary, radix curcumae, inula flower, achyranthes root, Chinese polyphaga, honeycomb, processed rhizoma cyperi, radix ophiopogonis, fig and silybum marianum, has the effects of detoxifying and improving symptoms, can finally reduce relapse, and is safe and reliable.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine prescriptions, and more particularly to a traditional Chinese medicine granule for treating liver cancer and a preparation method thereof. Background Art

[0002] Liver cancer (HCC) is a malignant tumor of the liver that can be divided into two categories: primary and secondary. Primary liver cancers originate from the epithelial or mesenchymal tissues of the liver. The former, known as primary liver cancer, is a highly prevalent and extremely harmful malignancy; the latter, known as sarcoma, is less common than primary liver cancer. Secondary or metastatic liver cancer refers to malignant tumors originating from multiple organs throughout the body that invade the liver. It is most commonly seen as liver metastasis from malignant tumors of organs such as the stomach, bile duct, pancreas, colorectum, ovary, uterus, lung, and breast.

[0003] Treatments for liver cancer include surgery, chemotherapy, interventional therapy, targeted drugs, immunotherapy, etc. However, they cannot cure the disease completely, and Western medicine treatments are also very harmful to the body.

[0004] Therefore, providing a liver cancer drug with good efficacy based on traditional Chinese medicine and a preparation method thereof is an urgent problem to be solved by those skilled in the art. Summary of the Invention

[0005] In view of this, the present invention provides a Chinese medicine granule for treating liver cancer and a preparation method thereof.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] A Chinese medicine granule for treating liver cancer is composed of the following raw materials in parts by weight: 10-30 parts of Solanum nigrum, 10-30 parts of Tongguangsan, 4-12 parts of Podophyllum, 4-12 parts of Fritillaria thunbergii, 10-30 parts of Scutellaria barbata, 10-30 parts of Hedyotis diffusa, 5-15 parts of Ganoderma lucidum, 5-15 parts of Phellinus igniarius, 7-21 parts of Polygonum cuspidatum, 7-21 parts of Herba Lycopodii, 5-15 parts of Radix Lycopodii, 7-21 parts of Radix Achyranthis Bidentatae, 5-15 parts of Taraxacum mongolicum, 5-15 parts of Roasted Trionycis, 15-45 parts of Astragalus membranaceus, It is composed of 3-9 parts of ginger pinellia, 2-6 parts of whole scorpion, 5-15 parts of reed rhizome, 7-21 parts of sedge vine, 5-15 parts of magnolia officinalis, 5-15 parts of codonopsis pilosula, 5-15 parts of yam, 5-15 parts of atractylodes macrocephala, 3-9 parts of stir-fried chicken gizzard lining, 5-15 parts of zedoaria, 5-15 parts of turmeric, 4-12 parts of inula flower, 5-15 parts of cyperus rotundus, 3-9 parts of earthworm, 3-9 parts of beehive, 5-15 parts of processed cyperus rotundus, 5-15 parts of ophiopogon, 5-15 parts of fig and 7-21 parts of milk thistle.

[0008] Preferably, the invention is composed of the following raw materials in parts by weight: 20 parts of Chen Longkui, 20 parts of Tongguangsan, 8 parts of Podophyllum, 8 parts of Fritillaria thunbergii, 20 parts of Scutellaria barbata, 20 parts of Hedyotis diffusa, 10 parts of Ganoderma lucidum, 10 parts of Phellinus igniarius, 15 parts of Polygonum cuspidatum, 15 parts of Herba Lycopodii, 10 parts of Rhizoma Cyperi, 15 parts of Radix Glehniae, 15 parts of Radix Glehniae, 10 parts of Radix Glehniae, 10 parts of Taraxacum, 10 parts of Rhizoma Cyperi, 30 parts of Astragalus, 6 parts of Rhizoma Pinelliae Rhizoma, 4 parts of Scorpio, 10 parts of Rhizoma Phragmites, 15 parts of Sargentophyllae, 10 parts of Rhizoma Curcumae, 10 parts of Codonopsis pilosulae, 10 parts of Dioscorea batatas, 10 parts of Atractylodes macrocephala, 6 parts of stir-fried Gizzard Gizzard Stone, 10 parts of Curcuma zedoaria, 10 parts of Curcuma aromatica, 8 parts of Flos Inulae, 10 parts of Radix Achyranthis Bidentatae, 6 parts of Eupolyphaga sinensis, 6 parts of Beehive, 10 parts of Rhizoma Cyperi processed, 10 parts of Radix Ophiopogonis, 10 parts of Fructus Figis and 15 parts of Milk Thistle.

[0009] The present invention also provides a preparation method of the above-mentioned Chinese medicine granules for treating liver cancer, comprising the steps of selecting, removing impurities, sun-drying, sterilizing and drying the raw materials, mixing and grinding them into powder according to a weight ratio, and forming granules using a granulator.

[0010] Preferably, the particle size of the powder is 200 mesh and the particle size of the granules is 3 mm.

[0011] The present invention also provides the use of the above-mentioned traditional Chinese medicine composition in pharmaceutical preparation.

[0012] The formula of the present invention includes the following principles: antiviral treatment as the main ingredient, supplemented by blood circulation and stasis removal. Therefore, Podophyllum japonicum and Tongguangsan are used as the main herbs, while Solanum nigrum, Fritillaria thunbergii, and Scutellaria barbata are used as the auxiliary herbs. When liver disease develops to a certain stage, the liver will become blocked, which can then develop into jaundice. Ganoderma lucidum, Coriolus linteus, Polygonum cuspidatum, Herba scutellariae, Radix Lycopodii, and Radix Rhizoma all work to relieve jaundice. Curcuma zedoariae and Curcuma aromatica soothe the liver and regulate qi, both entering the liver meridian. Achyranthes bidentatae, Eupolyphaga sinensis, Scorpio scorpion, and Beehive are used for their blood circulation and stasis removal effects. Phragmites australis nourishes blood. Sargent vine belongs to the liver meridian and has blood circulation and stasis removal effects. Herba scutellariae is a specific herb for liver cancer. Ophiopogon japonicus nourishes yin.

[0013] White Flower Hedyotis Diffusa: clears away heat and detoxifies, relieves pain and resolves stagnation, and promotes diuresis and eliminates dampness;

[0014] Codonopsis: replenishes spleen and lung qi, nourishes blood, and promotes body fluid production;

[0015] Chinese Yam: Strengthens the spleen, benefits the lungs, nourishes the kidneys, and improves essence;

[0016] Atractylodes macrocephala: invigorates the spleen and replenishes Qi, dries dampness and promotes urination;

[0017] Polygonum cuspidatum: diuretic, jaundice-reducing, heat-clearing and detoxifying, blood stasis-relieving and pain-relieving, cough-relieving and phlegm-resolving;

[0018] Creeping pot grass: clears heat and dampness, relieves jaundice and detoxifies;

[0019] Rhizoma Dioscoreae: clears dampness and heat, removes stones and relieves jaundice, reduces swelling and detoxifies;

[0020] Tianjihuang: clears away heat and detoxifies, promotes dampness and reduces jaundice, disperses blood stasis and reduces swelling;

[0021] Dandelion: clears away heat and detoxifies, eliminates carbuncle and swelling, and relieves dampness and stranguria;

[0022] Stir-fried chicken gizzard lining: invigorates the stomach and aids digestion, astringes semen and stops nocturnal emission;

[0023] Roasted turtle shell: nourishes yin and suppresses yang, softens and disperses lumps, reduces fever and eliminates steam, and resists fatigue;

[0024] Astragalus: replenishes Qi, stops sweating, promotes diuresis, reduces swelling, and discharges pus;

[0025] Ginger and Pinellia: dries dampness and resolves phlegm, relieves adverse reactions and stops vomiting, eliminates lumps and resolves stagnation;

[0026] Inula flower: promotes and descends the Qi of the lungs and stomach, eliminates phlegm, promotes Qi circulation, promotes diuresis, reduces adverse reactions and stops vomiting, soothes the liver and dredges the meridians;

[0027] Processed Cyperus rotundus: promotes qi and relieves depression, regulates menstruation and stops bleeding;

[0028] Figs: Strengthen the spleen, cleanse the intestines, reduce swelling, and detoxify;

[0029] Milk thistle: liver protection, anti-oxidation, and lipid-lowering.

[0030] The prescription of the present invention has the effects of detoxification and improving symptoms. At the same time, controlling diet, exercising and regulating emotions in daily life can ultimately reduce recurrence and is safe and reliable. DETAILED DESCRIPTION

[0031] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0032] Example 1

[0033] A traditional Chinese medicine granule for treating liver cancer is composed of the following raw materials in parts by weight: 30 parts of Solanum nigrum, 30 parts of Tongguangsan, 12 parts of Podophyllum, 4 parts of Fritillaria thunbergii, 10 parts of Scutellaria barbata, 10 parts of Hedyotis diffusa, 5 parts of Ganoderma lucidum, 5 parts of Phellinus igniarius, 7 parts of Polygonum cuspidatum, 7 parts of Herba Lycopodii, 5 parts of Rhizoma Cyperi, 7 parts of Radix Glehniae, 5 parts of Radix Glehniae, 5 parts of Taraxacum mongolica, 5 parts of roasted Carapace of Trionycis, 15 parts of Radix Astragali, 3 parts of Rhizoma Pinelliae Rhizoma Zingiberis, 2 parts of Scorpio, 5 parts of Rhizoma Phragmites, 7 parts of Sargentophyllae Caulis, 5 parts of Rhizoma Ophiopogonis, 5 parts of Codonopsis pilosula, 5 parts of Dioscorea batatas, 5 parts of Atractylodes macrocephala, 3 parts of stir-fried Gizzard Gizzard Stone, 5 parts of Curcuma zedoaria, 5 parts of Curcuma aromatica, 4 parts of Flos Inulae, 5 parts of Radix Achyranthis Bidentatae, 3 parts of Eupolyphaga sinensis, 3 parts of Beehive, 5 parts of processed Rhizoma Cyperi, 5 parts of Radix Ophiopogonis, 5 parts of Fructus Ficus, and 7 parts of Milk thistle.

[0034] Preparation method: Select the raw materials, dry them in the sun, remove impurities, put them in a drying room for sterilization and drying, compound the raw materials according to the ratio, grind them into powder with a fineness of 200 mesh using a crusher, and then use a special Chinese medicine granulator to make Chinese medicine granules with a particle size of about 3mm.

[0035] Directions: Pour 50-65g of Chinese medicine granules into a thermos bottle daily, add 900-1200ml of boiling water, and cool to approximately 40°C. Take 6-8 times a day, 150ml each time. Discard the residue. Be sure to quit smoking and drinking alcohol while taking this medicine.

[0036] Example 2

[0037] The invention discloses a traditional Chinese medicine granule for treating liver cancer. The granule is composed of the following raw materials in parts by weight: 20 parts of Solanum nigrum, 20 parts of Tongguangsan, 8 parts of Podophyllum, 8 parts of Fritillaria thunbergii, 20 parts of Scutellaria barbata, 20 parts of Hedyotis diffusa, 10 parts of Ganoderma lucidum, 10 parts of Phellinus igniarius, 15 parts of Polygonum cuspidatum, 15 parts of Herba Lycopodii, 10 parts of Rhizoma Cyperi, 15 parts of Radix Lycopodii, 15 parts of Radix Achyranthis Bidentatae, 30 parts of Radix Astragali, 6 parts of Rhizoma Pinelliae Rhizoma, 4 parts of Scorpio, 10 parts of Rhizoma Phragmites, 15 parts of Sargentophyllae, 10 parts of Rhizoma Cyperi, 10 parts of Rhizoma Codonopsis, 10 parts of Dioscorea batatas, 10 parts of Atractylodes macrocephala, 6 parts of stir-fried Gizzard Gizzard Stone, 10 parts of Curcuma zedoaria, 10 parts of Curcuma aromatica, 8 parts of Flos Inulae, 10 parts of Radix Achyranthis Bidentatae, 6 parts of Eupolyphaga sinensis, 6 parts of Beehive, 10 parts of processed Rhizoma Cyperi, 10 parts of Radix Ophiopogonis, 10 parts of Fructus Carthami, and 15 parts of Silybum marianum.

[0038] The preparation method and administration method are the same as those in Example 1.

[0039] Example 3

[0040] A traditional Chinese medicine granule for treating liver cancer is composed of the following raw materials in parts by weight: 10 parts of Solanum nigrum, 10 parts of Tongguangsan, 4 parts of Podophyllum, 12 parts of Fritillaria thunbergii, 30 parts of Scutellaria barbata, 30 parts of Hedyotis diffusa, 15 parts of Ganoderma lucidum, 15 parts of Phellinus igniarius, 21 parts of Polygonum cuspidatum, 21 parts of Herba Lycopodii, 15 parts of Rhizoma Cyperi, 21 parts of Radix Angelicae Dahuricae, 15 parts of Radix Lycopodii, 21 parts of Radix Achyranthis Bidentatae, 15 parts of Radix Glehniae, 15 parts of Taraxacum mongolica, 15 parts of roasted Carapace of Trionycis, 45 parts of Radix Astragali, 9 parts of Rhizoma Pinelliae Rhizoma Zingiberis, 6 parts of Scorpio, 15 parts of Rhizoma Phragmites, 21 parts of Sargentophyllae Caulis, 15 parts of Rhizoma Ophiopogonis, 15 parts of Codonopsis pilosula, 15 parts of Dioscorea batatas, 15 parts of Atractylodes macrocephala, 9 parts of stir-fried Gizzard Gizzard Stone, 15 parts of Curcuma zedoariae, 15 parts of Curcuma aromatica, 12 parts of Flos Inulae, 15 parts of Radix Achyranthis Bidentatae, 9 parts of Eupolyphaga sinensis, 9 parts of Beehive, 15 parts of processed Rhizoma Cyperi, 15 parts of Radix Ophiopogonis, 15 parts of Fructus Ficus and 21 parts of

[0041] The preparation method and administration method are the same as those in Example 1.

[0042] Technical effects:

[0043] 40 patients with liver cancer were observed. Initially, alpha-fetoprotein was found to be ≥500 μg / L. The Chinese medicine granules prepared in Example 2 were taken according to the method of taking in Example 1. After one month, the index decreased. After four months, 24 patients had alpha-fetoprotein close to normal values. After eight months, 9 patients had alpha-fetoprotein close to normal values.

[0044] Typical case 1:

[0045] Mr. Du, 58 years old, had primary liver cancer, which metastasized to intestinal cancer. His initial alpha-fetoprotein level was 687μg / L. After taking Chinese herbal granules for treating liver cancer for one month, his alpha-fetoprotein level dropped to 441μg / L. Three months later, his alpha-fetoprotein level was 24μg / L. He continued to take Chinese herbal medicine in gradually decreasing dosage without recurrence.

[0046] Typical case 2:

[0047] Mr. Ma, 71 years old, had primary liver cancer without metastasis. His initial alpha-fetoprotein level was 703μg / L. After taking Chinese herbal granules for liver cancer treatment for one month, his alpha-fetoprotein level dropped to 579μg / L. Seven months later, his alpha-fetoprotein level was 23μg / L. He continued to take Chinese herbal medicine in decreasing dosage without recurrence.

[0048] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0049] The above description of the disclosed embodiments is intended to enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A Chinese medicine granule for treating liver cancer, characterized in that: The invention is composed of the following raw materials in parts by weight: 10-30 parts of Chen Longkui, 10-30 parts of Tongguangsan, 4-12 parts of Podophyllum, 4-12 parts of Fritillaria thunbergii, 10-30 parts of Scutellaria barbata, 10-30 parts of Hedyotis diffusa, 5-15 parts of Ganoderma lucidum, 5-15 parts of Phellinus igniarius, 7-21 parts of Polygonum cuspidatum, 7-21 parts of Herba Lycopodii, 5-15 parts of Radix Glehniae, 7-21 parts of Radix Achyranthis Bidentatae, 5-15 parts of Taraxacum mongolicum, 5-15 parts of Roasted Trionycis, 15-45 parts of Radix Astragali, 3-9 parts of Rhizoma Pinelliae Rhizoma 5-15 parts of Chinese wolfberry, 2-6 parts of whole scorpion, 5-15 parts of reed rhizome, 7-21 parts of Sargentodon grandiflora, 5-15 parts of magnolia officinalis, 5-15 parts of Codonopsis pilosula, 5-15 parts of Chinese yam, 5-15 parts of Atractylodes macrocephala, 3-9 parts of stir-fried chicken gizzard lining, 5-15 parts of Curcuma zedoaria, 5-15 parts of Curcuma aromatica, 4-12 parts of Inula flower, 5-15 parts of Cyperus rotundus, 3-9 parts of Eupolyphaga sinensis, 3-9 parts of Beehive, 5-15 parts of processed Cyperus rotundus, 5-15 parts of Ophiopogon japonicus, 5-15 parts of Fructus ficifolia and 7-21 parts of Silybum marianum.

2. The Chinese medicine granules according to claim 1, characterized in that The invention is composed of the following raw materials in parts by weight: 20 parts of dried longan kirilowii, 20 parts of tongguangsan, 8 parts of podophyllum, 8 parts of thunbergii fritillary, 20 parts of scutellaria barbata, 20 parts of oldenlandia diffusa, 10 parts of ganoderma lucidum, 10 parts of mulberry lindera, 15 parts of knotweed, 15 parts of scutellaria baicalensis, 10 parts of rhizoma scutellariae, 10 parts of roasted turtle shell, 30 parts of astragalus, 6 parts of ginger pinellia, 4 parts of scorpion, 10 parts of reed rhizome, 15 parts of safflower vine, 10 parts of umbelliferae, 10 parts of codonopsis pilosula, 10 parts of yam, 10 parts of atractylodes macrocephala, 6 parts of stir-fried chicken gizzard lining, 10 parts of zedoaria, 10 parts of turmeric, 8 parts of inula flower, 10 parts of cyperus rotundus, 6 parts of earthworm, 6 parts of honeycomb, 10 parts of processed cyperus rotundus, 10 parts of ophiopogon, 10 parts of ficus carica and 15 parts of milk thistle.

3. The method for preparing the Chinese medicinal granules for treating liver cancer according to claim 1 or 2, characterized in that: The raw materials are selected, impurities removed, sun-dried, sterilized and oven-dried, then mixed and ground into powder according to weight proportion, and granulated using a granulator.

4. The method for preparing the Chinese medicine granules according to claim 3, characterized in that: The particle size of the powder is 200 mesh, and the particle size of the granules is 3 mm.

5. Use of the Chinese medicine composition according to claim 1 or 2 in pharmaceutical preparation.