Eye protection liquid for relieving eye fatigue and dryness and preparation method thereof

Abstract

The invention discloses eye protection liquid for relieving eye fatigue and dryness and a preparation method of the eye protection liquid, and particularly belongs to the technical field of eye care. The eye protection liquid contains a composition for relieving eye fatigue and dryness, auxiliary materials and a solvent, the composition is prepared from the following components in parts by mass: 20 to 30 parts of rhodiola crenulata root extract, 10 to 20 parts of butterflybush flower extract, 0.1 to 0.4 part of hedychium coronarium extract and 0.4 to 0.5 part of palmarosa extract. According to the composition provided by the invention, the rhodiola crenulata root extract, the butterflybush flower extract, the hedychium coronarium extract and the palmarosa herb extract are used as key functional components, so that the improvement of rabbit eye secretions can be accelerated, and the lesions of cornea, iris and conjunctiva can be relieved; when the rhodiola crenulata root extract, the butterflybush flower extract, the hedychium coronarium extract and the palmarosa extract are compounded for use, a certain synergistic effect is achieved, and multi-dimensional and multi-channel eye health maintenance is achieved. The eye protection liquid provided by the invention has obvious effects in the aspects of relieving eye fatigue and dryness and improving eye comfort.

Description

Technical Field

[0001] The present invention belongs to the technical field of eye care, and in particular relates to an eye protection liquid for relieving eye fatigue and dryness and a preparation method thereof. Background Art

[0002] In today's society, with changing lifestyles and the widespread use of electronic devices, eye problems are becoming increasingly prominent, with eye fatigue and dryness becoming common. Prolonged time spent in front of computer screens, mobile phones, and other electronic devices keeps the ciliary muscles tense, depriving the eyes of adequate rest, leading to eye fatigue. Furthermore, environmental factors, aging, and prolonged contact lens wear can lead to decreased tear production or rapid evaporation, disrupting the tear film's stability and causing dry eyes.

[0003] Although there are a variety of eye care products on the market to alleviate these problems, these products often have certain limitations. For example, artificial tears can only temporarily relieve ocular surface dryness, but cannot improve ciliary muscle spasm fatigue. Frequent use may also disrupt tear film homeostasis. Long-term use of anti-inflammatory drugs (such as cyclosporine A) carries the risk of increased intraocular pressure and corneal damage. Moreover, many products are less than ideal in relieving eye fatigue and dryness, and cannot fundamentally solve the problems of tear deficiency and eye muscle fatigue, making it difficult to meet people's growing demand for eye health care. Summary of the Invention

[0004] In view of the shortcomings of the prior art, the present invention aims to provide a composition, an eye protection liquid product and a preparation method thereof that can effectively relieve eye fatigue and dryness.

[0005] In order to achieve the above object, the present invention discloses the following technical solutions:

[0006] In a first aspect, the present invention provides a composition for relieving eye fatigue and dryness, wherein the composition comprises the following components in parts by mass:

[0007] 20-30 parts of Rhodiola rosea root extract;

[0008] 10-20 parts of Buddleja buddleja extract;

[0009] 0.1-0.4 parts of ginger flower extract;

[0010] 0.4-0.5 parts of Palmarosa extract.

[0011] Preferably, the preparation method of the Rhodiola rosea root extract comprises the following steps:

[0012] Step 1-1. Grind and sieve the dried Rhodiola rosea root to obtain Rhodiola rosea powder;

[0013] Step 1-2. Mix Rhodiola rosea powder and deionized water in a mass volume ratio of 1: (15-20) g / mL, soak for 1-1.5 hours, and then place in an essential oil distillation device for distillation extraction for 3-4 hours. Select the distilled Rhodiola rosea root hydrosol to obtain the Rhodiola rosea root extract.

[0014] Preferably, the preparation method of the ginger flower extract comprises the following steps:

[0015] Step 2-1. Take the dried ginger flower part and place it in a grinder and grind and sieve to obtain ginger flower powder;

[0016] Step 2-2. The ginger flower powder is mixed with deionized water in a mass volume ratio of 1: (30-35) g / mL, soaked for 1-1.5 hours, and then placed in an essential oil distillation device for distillation extraction for 3-4 hours. The distilled ginger flower essential oil is selected to obtain the ginger flower extract.

[0017] Preferably, the preparation method of the palm grass extract comprises the following steps:

[0018] Step 3-1. Take the dried whole herb of Cyperus rotundus and place it in a grinder and grind and sieve to obtain Cyperus rotundus powder;

[0019] Step 3-2. The palm grass powder and deionized water are mixed in a mass volume ratio of 1: (30-35) g / mL and soaked for 1-1.5 hours, then placed in an essential oil distillation device, distilled and extracted for 3-4 hours, and the distilled palm grass essential oil is selected to obtain the palm grass extract.

[0020] Preferably, the preparation method of the Buddleja buddleja extract comprises the following steps:

[0021] Step 4-1. Take the dried Buddleja budsii flower part and place it in a grinder and grind and sieve to obtain Buddleja budsii flower powder;

[0022] Step 4-2. Mix the Buddleja flower powder and deionized water in a mass volume ratio of 1: (15-20) g / mL, soak for 1-1.5 hours, and then place it in an essential oil distillation device for distillation extraction for 3-4 hours. Select the distilled Buddleja flower hydrosol to obtain the Buddleja flower extract.

[0023] In a second aspect, the present invention provides an eye protection liquid for relieving eye fatigue and dryness, wherein the eye protection liquid contains the composition according to the first aspect;

[0024] The composition is added to the eye protection solution in an amount of 5-10%.

[0025] Preferably, the eye protection solution further contains auxiliary materials and solvents.

[0026] Further preferably, the excipient is at least one of glycerin, 1,2-hexanediol, methylparaben, cassia gelatin, acrylic acid (ester) / VP copolymer, sodium hyaluronate and taurine;

[0027] The solvent is deionized water.

[0028] In a third aspect, the present invention provides a method for preparing the eye protection solution according to the second aspect, the preparation method comprising the following steps:

[0029] Step 5-1. First, ginger flower extract and palm grass extract were added to deionized water, glycerin was added, and stirred at a speed of 300-400 r / min for 10-15 min. After mixing, Rhodiola rosea root extract, Buddleja flower extract, 1,2-hexanediol, and methylparaben were added and stirred at a speed of 1000-2000 r / min for 10-15 min to obtain a mixed solution A;

[0030] Step 5-2. Heat deionized water to 70-80°C, add Cassia gelatin and acrylic acid (ester) / VP copolymer, stir at 300-400 rpm for 20-30 min, cool to 50-60°C, add sodium hyaluronate, and continue stirring at 300-400 rpm for 20-30 min to obtain a mixed solution B;

[0031] Step 5-3. Cool the mixed solution B to 30-40°C, add the mixed solution A and taurine, stir at 300-400 r / min for 20-30 min, and finally pass through a 300-400 mesh sieve to obtain the eye protection solution.

[0032] In a fourth aspect, the present invention provides use of the composition described in the first aspect in preparing an eye protection product having the effect of relieving eye fatigue and / or relieving dry eyes.

[0033] In the present invention:

[0034] Rhodiola rosea is a precious medicinal plant with benefits including enhancing immunity, combating fatigue, alleviating hypoxia, regulating blood pressure, and promoting blood circulation. This invention uses Rhodiola rosea root as raw material, and distills it to produce a Rhodiola rosea root hydrosol. This hydrosol is rich in flavonoids, terpenoids, sterols, and volatile oils, and has antioxidant, antibacterial, anti-inflammatory, and blood circulation-boosting properties, improving eye comfort and reducing ocular inflammation caused by overuse.

[0035] The Buddleja buddhist extract provided by the present invention is rich in active substances such as flavonoids, phenylethanoid glycosides, and iridoids, which can significantly inhibit the apoptosis of lacrimal gland cells, promote mucin secretion, and repair the mucus layer on the ocular surface. At the same time, it can inhibit the release and expression of inflammatory factors, relieve eye itching and congestion, and achieve the effect of improving eyesight.

[0036] The ginger flower extract provided by the present invention is rich in volatile active ingredients such as sesquiterpenoid compounds, monoterpenoid compounds, and oxidized terpenoid compounds, which can inhibit bacteria and inflammation, resist oxidative damage, promote blood circulation and remove blood stasis. At the same time, it has the effect of promoting transdermal absorption of the skin. After being combined with other ingredients provided by the present invention, the absorption rate of the active substances is improved.

[0037] The palm grass extract provided by the present invention is rich in active substances such as geraniol, geranyl acetate, linalool, ocimene, β-caryophyllene, etc., and has excellent antioxidant, anti-inflammatory, antibacterial and skin penetration promoting effects.

[0038] Beneficial effects of the present invention:

[0039] 1. The composition provided by the present invention, including Rhodiola rosea root extract, Buddleja flos extract, Zingiber officinale extract and Palmarosa officinalis extract as key effective ingredients, can accelerate the improvement of rabbit eye secretions and alleviate lesions of the cornea, iris and conjunctiva, and the Rhodiola rosea root extract, Buddleja flos extract, Zingiber officinale extract and Palmarosa officinalis extract have a certain synergistic effect when used in combination, achieving multi-dimensional and multi-pathway maintenance of eye health.

[0040] 2. The eye protection solution provided by the present invention has a significant effect in relieving eye fatigue, dryness and improving eye comfort. DETAILED DESCRIPTION

[0041] The following will clearly and completely describe the technical solutions of the present invention in conjunction with the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0042] In order to further illustrate the present invention, the following examples are provided for detailed description. The raw materials used in the following examples and comparative examples of the present invention are all commercially available commodities.

[0043] Preparation of Rhodiola rosea root extract:

[0044] Step 1-1. Take the dried root of Rhodiola rosea and grind it through a 30-mesh sieve in a grinder to obtain Rhodiola rosea powder;

[0045] Step 1-2. Mix Rhodiola rosea powder and deionized water in a mass-to-volume ratio of 1: (15-20) g / mL, soak for 1-1.5 hours, and then place in an essential oil distillation device for distillation extraction for 3-4 hours. The distilled Rhodiola rosea root hydrosol is selected to obtain the Rhodiola rosea (RHODIOLA CRENULATA) root extract.

[0046] Preparation of ginger flower extract:

[0047] Step 2-1. Take the dried ginger flower part and grind it into a grinder and pass it through a 30-mesh sieve to obtain ginger flower powder;

[0048] Step 2-2. Mix ginger flower powder and deionized water at a mass volume ratio of 1: (30-35) g / mL, soak for 1-1.5 hours, and then place in an essential oil distillation device for distillation extraction for 3-4 hours. The distilled ginger flower essential oil is selected, which is the ginger flower (HEDYCHIUMCORONARIUM) extract.

[0049] Preparation of Palmarosa Extract:

[0050] Step 3-1. Take the dried whole grass of Cyperus rotundus and grind it through a 30-mesh sieve in a grinder to obtain Cyperus rotundus powder;

[0051] Step 3-2. Mix the palm grass powder and deionized water in a mass volume ratio of 1: (30-35) g / mL, soak for 1-1.5 hours, and then place it in an essential oil distillation device for distillation extraction for 3-4 hours. The distilled palm grass essential oil is selected as the palm grass (CYMBOPOGON MARTINI) extract.

[0052] Preparation of Buddleja flower extract:

[0053] Step 4-1. Take the dried Buddleja buddleja flower part and grind it through a 30-mesh sieve in a grinder to obtain Buddleja buddleja powder;

[0054] Step 4-2. Mix the Buddleja officinalis powder and deionized water in a mass volume ratio of 1: (15-20) g / mL, soak for 1-1.5 hours, and then place it in an essential oil distillation device for distillation extraction for 3-4 hours. The distilled Buddleja officinalis hydrosol is selected as the Buddleja officinalis extract.

[0055] Composition for relieving eye fatigue and dryness

[0056] The effective ingredients are compounded according to the mass ratio in Table 1 to obtain a composition for relieving eye fatigue and dryness;

[0057] Table 1 Mass ratio of each component in the composition

[0058] Raw material name Composition 1 Composition 2 Composition 3 Composition 4 Rhodiola rosea root extract 20 25 25 30 Buddleja flower extract 20 15 15 10 Ginger Flower Extract 0.1 0.2 0.3 0.4 Palmarosa Extract 0.4 0.45 0.45 0.5

[0059] Eye drops 1-4

[0060] Preparation method of eye protection solution:

[0061] Step 5-1. First, ginger flower extract and palm grass extract were added to deionized water, glycerin was added, and stirred at a speed of 300-400 r / min for 10-15 min. After mixing, Rhodiola rosea root extract, Buddleja flower extract, 1,2-hexanediol, and methylparaben were added and stirred at a speed of 1000-2000 r / min for 10-15 min to obtain a mixed solution A;

[0062] Step 5-2. Heat deionized water to 70-80°C, add Cassia obtusifolia gum and acrylic acid (ester) / VP copolymer, stir at 300-400 rpm for 20-30 min, cool to 50-60°C, add sodium hyaluronate, and continue stirring at 300-400 rpm for 20-30 min to obtain a mixed solution B.

[0063] Step 5-3. Cool the mixed solution B to 30-40° C., add the mixed solution A and taurine, stir at 300-400 rpm for 20-30 min, and finally pass through a 300-400 mesh sieve and bottle to obtain the eye protection solution.

[0064] The specific mass percentages of each raw material are shown in Table 2.

[0065] Table 2 Mass percentage of each raw material in eye protection solution

[0066]

[0067]

[0068] Note: “ / ” in the table means no additive.

[0069] Performance Testing

[0070] Preparation of eye protection solution for the control group

[0071] The following compositions 5-8 are based on the formula of composition 2 and are omitted to verify the role of each ingredient in the formula;

[0072] Table 3 Mass ratio of each component in compositions 5-8

[0073] Raw material name Composition 5 Composition 6 Composition 7 Composition 8 Rhodiola rosea root extract / 40 25 25 Buddleja flower extract 40 / 15 15 Ginger Flower Extract 0.2 0.2 / 0.65 Palmarosa Extract 0.45 0.45 0.65 /

[0074] Note: “ / ” in the table means no additive.

[0075] The preparation method of the comparative eye protection solution refers to the preparation method of the aforementioned eye protection solution 1-4, and the specific mass percentage of each raw material is as shown in Table 4;

[0076] Table 4 Mass percentage of each raw material in comparison groups 1-4

[0077]

[0078]

[0079] Note: “ / ” in the table means no additive.

[0080] 1 Security Testing

[0081] 1.1 Experimental animals and treatment

[0082] 1.1.1 Animal selection and preparation

[0083] Healthy adult New Zealand rabbits (weighing ≥ 2 kg) were selected and acclimated in the animal room for at least 3 days prior to the experiment to ensure that their eyes showed no abnormalities (e.g., redness, swelling, discharge, etc.). Each group consisted of four rabbits, each receiving the test substance from Eye Protectant 1-4 and Control Groups 1-4. The left eye of each rabbit served as the test eye, and the right eye served as an untreated control.

[0084] 1.1.2 Method of administration

[0085] First, restrain the rabbit. Gently pull open the lower eyelid of the test eye and use a micropipette to instill 0.1 mL of the test substance into the conjunctival sac. Passively close the eyelid for 1 second to prevent loss of the test substance. Do not irrigate the eye within 24 hours. If the test substance is a potential strong irritant, gently rinse with normal saline after 24 hours.

[0086] 1.1.3 Supplementary flushing test (if irritating)

[0087] If the initial test results indicate that the test substance is irritating, perform irrigation on four additional rabbits to verify the ocular surface irrigating effect: 30 seconds after instillation of the test substance, immediately irrigate the ocular surface with sufficient saline at a flow rate of 10 mL / s for at least 30 seconds. Observe changes in the irritant response after irrigation.

[0088] 1.2 Observation indicators and scoring

[0089] 1.2.1 Inspection Time

[0090] Eye examinations were performed 1, 24, 48, 72 hours after administration, and on days 4 and 7. If no irritation reaction occurred within 72 hours (total score ≤ 1), the experiment could be terminated early.

[0091] 1.2.2 Scoring Criteria

[0092] Scores were made based on the cornea, iris, conjunctiva, edema and secretions of each rabbit's test eye. The specific scores are shown in the following table:

[0093] Table 5 Stimulation scoring criteria

[0094]

[0095]

[0096] The above five scores were added together to obtain the total score of monocular stimulation for each rabbit. Finally, the average value of the four rabbits in each group was used as the stimulation evaluation score for the group.

[0097] 1.2.3 Irritation classification

[0098] 0-1 points: no irritation, 1-4 points: mild irritation, 4-7 points: moderate irritation, >7 points: severe irritation.

[0099] 1.3 Irritation results

[0100] When the eyes of the four rabbits in each group were examined at 1, 24, 48, and 72 hours, no corneal, iris, or conjunctival lesions, edema, or discharge were observed, and the total eye irritation score was zero. This indicates that the test substances in Eye Protection Solutions 1-4 and Control Groups 1-4 are safe and non-irritating.

[0101] 2 Animal efficacy tests

[0102] 2.1 Rabbit UV eye damage model

[0103] 45 adult New Zealand rabbits, 5 in each group, were fixed with rabbit clips and irradiated with a 254 nm wavelength UV lamp at a distance of 40 cm from the rabbit's eyes at an intensity of 5000 μW / cm 2 On the first day, the rabbits were irradiated for 3 hours in the morning and 1 hour in the afternoon. On the second and third days, the rabbits were irradiated for 2 hours in the morning and 2 hours in the afternoon, for a total of 12 hours, to establish a rabbit UV irradiation eye damage model.

[0104] 2.2 Grouping and Dosing

[0105] Rabbits were randomly divided into nine groups: eye drops groups 1-4, control groups 1-4, and a blank group. Each group received the test substance corresponding to eye drops 1-4, control groups 1-4, and a blank group. Immediately after the last irradiation, the rabbits' eyelids were lifted and the drug was dripped into the conjunctival sac, where it remained for at least 10 seconds, with the eyelids closed three times in between. Eye drops were administered four times daily, one drop (0.05 mL) per eye, every two hours, for six consecutive days. The degree of damage and ocular secretions were observed before and six days after UV light irradiation, and the evaluation was based on the scoring criteria in Table 5.

[0106] 2.3 Statistical methods

[0107] The data were statistically analyzed using SPSS19 statistical software. Paired T test or paired rank sum test was used for comparison between before and after administration. T test was used for comparison between groups if the data conformed to normal distribution, and rank sum test was used if not, with α = 0.05.

[0108] 2.3 Test results

[0109] Table 6 Test results

[0110] Group Sample size n Pre-dose scoring Post-dose scoring Eye drops 1 5 11.0±1.6 0.6±0.5*** Eye drops 2 5 10.8±1.3 0.4±0.5*** Eye drops 3 5 11.6±1.7 1.0±0.7*** Eye drops 4 5 11.4±1.7 0.8±0.8*** Comparison group 1 5 11.0±0.7 3.6±0.5***### Comparison group 2 5 11.2±1.8 4.0±1.0***### Comparison group 3 5 10.2±1.5 4.6±1.5***### Comparison group 4 5 11.2±0.8 5.0±1.0***### Blank group 5 10.2±1.3 9.6±1.5###

[0111] Note: In the table, "***" indicates that the difference between the two groups after administration is extremely significant, P < 0.001; "###" indicates that the difference between the two groups after administration is extremely significant, P < 0.001.

[0112] 2.4 Results Analysis

[0113] According to the results in Table 6, the average eye irritation score of the blank group rabbits on the 6th day was 9.6, which was not significantly different from that before administration. After administration, the eye protection liquids 1-4 and the control groups 1-4 significantly improved the rabbit eyes after UV damage compared with before administration, indicating that the composition provided by the present invention, including the root extract of Rhodiola rosea, the extract of Buddleja flos, the extract of ginger flower and the extract of Cyperus rotundus, as key effective ingredients, can accelerate the improvement of rabbit eye secretions and alleviate the lesions of the cornea, iris and conjunctiva; compared with the control groups 1-4, the improvement effect of the eye protection liquid 2 was significantly better than that of the control group, indicating that the root extract of Rhodiola rosea, the extract of Buddleja flos, the extract of ginger flower and the extract of Cyperus rotundus have a certain synergistic effect when used in combination, and maintain the health of the eyes in multiple dimensions and multiple pathways.

[0114] 3 Human efficacy tests

[0115] 3.1 Experimental subjects

[0116] Thirty healthy volunteers (20 males and 10 females), aged between 20 and 40 years old, all had symptoms of frequent eye fatigue (such as dry eyes, blurred vision, fatigue, etc.).

[0117] 3.2 Test substances and groups

[0118] The test substances were Eye Protection Solution 2 and commercially available eye ointment.

[0119] Eye protection solution group 2: 15 volunteers used the eye protection solution 2 test substance prepared by the above method every day.

[0120] Control group: 15 volunteers used eye ointment on the market (which claims to relieve dry eyes and eye fatigue).

[0121] 3.3 Usage

[0122] Take an appropriate amount of the test substance and apply it evenly around the eyes, including the upper and lower eyelids, with eyes closed. Use it once in the morning and evening each day, keeping eyes closed for 10 minutes each time to allow it to be effectively absorbed.

[0123] 3.4 Evaluation Criteria

[0124] Eye fatigue: assessed using a subjective visual fatigue rating scale (VAS scale, ranging from 0 to 10, with higher scores indicating more fatigue);

[0125] Dry eye symptoms: assessed using the subjective eye dryness rating scale (OSDI, with a scale of 0-10, where the higher the score, the drier and more uncomfortable it is);

[0126] Eye comfort: assessed using a subjective eye comfort rating scale (0-10, with higher scores indicating greater comfort).

[0127] Evaluation data were collected before and after the experiment, and changes in symptoms of eye fatigue were recorded. The experimental data are shown in Table 7.

[0128] 3.5 Test results

[0129] Table 7 Results of changes in eye fatigue symptoms

[0130]

[0131] 3.5 Results Analysis

[0132] It can be seen from the experimental results that the eye protection liquid provided by the present invention and the commercially available eye protection ointment both have certain effects on improving eye fatigue and dry eyes. Among them, the eye protection liquid provided by the present invention shows better efficacy than the commercially available products.

[0133] In summary, the eye protection solution provided by the present invention has significant effects in relieving eye fatigue, dryness and improving eye comfort.

[0134] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or substitute equivalents for some of the technical features. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A composition for relieving eye fatigue and dryness, characterized in that: The composition comprises the following components in parts by mass: 20-30 parts of Rhodiola rosea root extract; 10-20 parts of Buddleja buddleja extract; 0.1-0.4 parts of ginger flower extract; 0.4-0.5 parts of Palmarosa extract.

2. The composition according to claim 1, characterized in that The preparation method of the Rhodiola rosea root extract comprises the following steps: Step 1-1. Grind and sieve the dried Rhodiola rosea root to obtain Rhodiola rosea powder; Step 1-2. Mix Rhodiola rosea powder and deionized water in a mass volume ratio of 1: (15-20) g / mL, soak for 1-1.5 hours, and then place in an essential oil distillation device for distillation extraction for 3-4 hours. Select the distilled Rhodiola rosea root hydrosol to obtain the Rhodiola rosea root extract.

3. The composition according to claim 1, characterized in that The preparation method of the ginger flower extract comprises the following steps: Step 2-1. Take the dried ginger flower part and place it in a grinder and grind and sieve to obtain ginger flower powder; Step 2-2. The ginger flower powder is mixed with deionized water in a mass volume ratio of 1: (30-35) g / mL, soaked for 1-1.5 hours, and then placed in an essential oil distillation device for distillation extraction for 3-4 hours. The distilled ginger flower essential oil is selected to obtain the ginger flower extract.

4. The composition according to claim 1, characterized in that The preparation method of the Cyperus rotundus extract comprises the following steps: Step 3-1. Take the dried whole herb of Cyperus rotundus and place it in a grinder and grind and sieve to obtain Cyperus rotundus powder; Step 3-2. The palm grass powder and deionized water are mixed in a mass volume ratio of 1: (30-35) g / mL and soaked for 1-1.5 hours, then placed in an essential oil distillation device, distilled and extracted for 3-4 hours, and the distilled palm grass essential oil is selected to obtain the palm grass extract.

5. The composition according to claim 1, characterized in that The preparation method of the Buddleja buddleja extract comprises the following steps: Step 4-1. Take the dried Buddleja budsii flower part and place it in a grinder and grind and sieve to obtain Buddleja budsii flower powder; Step 4-2. Mix the Buddleja flower powder and deionized water in a mass volume ratio of 1: (15-20) g / mL, soak for 1-1.5 hours, and then place it in an essential oil distillation device for distillation extraction for 3-4 hours. Select the distilled Buddleja flower hydrosol to obtain the Buddleja flower extract.

6. An eye protection solution for relieving eye fatigue and dryness, characterized in that: The eye protection solution contains the composition according to any one of claims 1 to 5; The composition is added to the eye protection solution in an amount of 5-10%.

7. The eye protection solution according to claim 6, characterized in that The eye protection solution also contains auxiliary materials and solvents.

8. The eye protection solution according to claim 7, characterized in that The auxiliary material is at least one of glycerin, 1,2-hexanediol, methylparaben, cassia gum, acrylic acid (ester) / VP copolymer, sodium hyaluronate and taurine; The solvent is deionized water.

9. The method for preparing the eye protection solution according to claim 8, characterized in that: The preparation method comprises the following steps: Step 5-1. First, ginger flower extract and palm grass extract were added to deionized water, glycerin was added, and stirred at a speed of 300-400 r / min for 10-15 min. After mixing, Rhodiola rosea root extract, Buddleja flower extract, 1,2-hexanediol, and methylparaben were added and stirred at a speed of 1000-2000 r / min for 10-15 min to obtain a mixed solution A; Step 5-2. Heat deionized water to 70-80°C, add Cassia gelatin and acrylic acid (ester) / VP copolymer, stir at 300-400 rpm for 20-30 min, cool to 50-60°C, add sodium hyaluronate, and continue stirring at 300-400 rpm for 20-30 min to obtain a mixed solution B; Step 5-3. Cool the mixed solution B to 30-40°C, add the mixed solution A and taurine, stir at 300-400 r / min for 20-30 min, and finally pass through a 300-400 mesh sieve to obtain the eye protection solution.

10. Use of the composition according to any one of claims 1 to 5 in the preparation of an eye protection product having the effect of relieving eye fatigue and / or relieving dry eyes.

Images