Antiperspirant and deodorant composition and application thereof in male products

Abstract

The invention relates to a hidroschesis and deodorization composition and application thereof in male products. The composition is prepared from the following components: a radix sophorae flavescentis extract, an oldenlandia diffusa extract, a salvia officinalis extract, a roselle flower extract and a radix ophiopogonis root extract, wherein the weight ratio of the radix sophorae flavescentis extract to the oldenlandia diffusa extract to the salvia officinalis extract to the roselle flower extract to the radix ophiopogonis root extract is (0.05 to 2) to (0.01 to 1) to (0.01 to 1) to (0.005 to 2) to (0.01 to 1). According to the composition disclosed by the invention, through reasonable matching of the components, the deodorization purpose can be achieved from two aspects of inhibiting hidroschesis and inhibiting bacteria, the influence of androgen on sweating is regulated in a targeted manner, and the composition is more suitable for being added into male products.

Description

Technical Field

[0001] The present invention relates to the technical field of men's products, and in particular to an antiperspirant and deodorant composition and application thereof in men's products. Background Art

[0002] In daily life, body odor can affect people's self-confidence and quality of life. Studies have shown that people are more likely to perceive others positively when they smell pleasant. Deodorant cosmetics are used to prevent or eliminate unpleasant body odor (primarily underarm odor) and are generally composed of antiperspirants, deodorants, antiseptics, and fragrances.

[0003] Body odor is an abnormal physiological phenomenon caused by the interaction between microorganisms and sweat. Human skin contains approximately 2 to 5 million sweat glands, divided into two types: eccrine and apocrine. Eccrine sweat glands, also known as local sweat glands and small sweat glands, are found throughout the skin, but their number varies significantly between different skin locations. Apocrine sweat glands, also known as large sweat glands, are primarily found in areas such as the axilla. Eccrine sweat glands receive extensive vascular and neural innervation, with neural input primarily from sympathetic cholinergic fibers controlling the regulation of sweat secretion. Studies have shown that androgen receptors are highly expressed in apocrine sweat glands, suggesting that androgens may stimulate apocrine sweat gland activity, leading to the secretion of more non-volatile precursors. These precursors are then broken down by bacteria on the skin surface to form volatile odorants, which contribute to body odor. This is also why men have a stronger body odor than women.

[0004] The axillary flora associated with axillary odor mainly include Corynebacterium, Staphylococcus and anaerobic bacteria. Studies have shown that Corynebacterium is the main cause of axillary odor.

[0005] Currently, antiperspirant and deodorant products on the market mainly rely on aluminum salts to stop sweat or add fragrance to cover up the odor to achieve the purpose of deodorization. Their inhibitory effect on the odor produced by bacteria decomposing sweat is relatively limited.

[0006] In summary, in addition to comprehensively considering the antiperspirant and antibacterial effects, men's deodorant products also need to consider the impact of androgens on axillary odor. Summary of the Invention

[0007] The purpose of the present invention is to overcome the shortcomings of the prior art and provide an antiperspirant and deodorant composition and its application in men's products.

[0008] To achieve the above object, the technical solution adopted by the present invention is:

[0009] In a first aspect, the present invention provides an antiperspirant and deodorant composition comprising the following components: a Sophora flavescens root extract, a Hedyotis diffusa extract, a Sage extract, a Hibiscus sabdariffa flower extract, and a Radix Ophiopogonis root extract, wherein the weight ratio of the Sophora flavescens root extract, the Hedyotis diffusa extract, the Sage extract, the Hibiscus sabdariffa flower extract, and the Radix Ophiopogonis root extract is (0.05-2):(0.01-1):(0.01-1):(0.005-2):(0.01-1).

[0010] The effects of the components of the composition are as follows:

[0011] The alkaloids and flavonoids in Sophora flavescens root extract can destroy bacterial cell membranes, interfere with protein synthesis, and have inhibitory effects on a variety of Gram-positive and Gram-negative bacteria, as well as fungi. In addition, Sophora flavescens root extract can inhibit 5-α-reductase activity and reduce dihydrotestosterone production.

[0012] Some sesquiterpenes and flavonoids in Hedyotis diffusa extract can bind to androgen receptors, occupying binding sites. Therefore, it is speculated that this extract may reduce the binding of DHT to androgen receptors, thereby reducing sweat secretion.

[0013] The carnosic acid in sage extract can inhibit the cholinergic receptors in the sweat glands, thereby reducing the secretion of sweat glands.

[0014] Roselle flower extract has a good inhibitory effect on Gram-negative and Gram-positive bacteria. In addition, the organic acid in it can also change the alkaline environment of the armpit, which is not conducive to the growth of odor-producing bacteria (especially Corynebacterium).

[0015] The steroidal saponins, polysaccharides, flavonoids and other ingredients in Ophiopogon japonicus root extract also have certain antibacterial and anti-inflammatory effects, which can relieve the inflammatory response caused by excessive bacterial growth.

[0016] Preferably, the weight ratio of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract and Ophiopogon japonicus root extract is (0.1-1):(0.1-0.5):(0.05-0.5):(0.01-0.05):(0.05-0.5).

[0017] More preferably, the weight ratio of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract and Ophiopogon japonicus root extract is (0.4-0.6):(0.2-0.4):(0.1-0.3):(0.1-0.3):(0.05-0.15).

[0018] Most preferably, the mass ratio of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract and Ophiopogon japonicus root extract is 0.5:0.3:0.2:0.2:0.1

[0019] In a second aspect, the present invention provides use of the antiperspirant and deodorant composition of the first aspect in the preparation of men's products.

[0020] Preferably, it is characterized in that the men's product is a spray, a roll-on liquid, a gel, a gel or a wet wipe, and the added amount of the composition is 1%-10% of the total weight of the men's product.

[0021] In a third aspect, the present invention provides a roll-on liquid comprising the following raw materials in weight percentage: 1%-10% of the antiperspirant and deodorant composition described in the first aspect, 4%-14% of a moisturizer, 0.5%-3% of a preservative, 0.01-0.05% of a thickener, and 0.01%-0.3% of a pH regulator, with the remainder being deionized water.

[0022] Preferably, the humectant is glycerol and / or sorbitol.

[0023] Preferably, the preservative includes at least one of 1,3-propylene glycol, 1,2-hexanediol and p-hydroxyacetophenone.

[0024] Preferably, the thickener is xanthan gum.

[0025] Preferably, the pH adjuster is disodium EDTA.

[0026] In a fourth aspect, the present invention provides a method for preparing the roll-on solution of the third aspect, comprising the following steps:

[0027] S1. Adding 4-6 times the total mass of water to each component of the antiperspirant and deodorant composition and mixing with stirring to obtain an antiperspirant and deodorant composition solution;

[0028] S2. mixing the preservative and a portion of deionized water, and dissolving the mixture at 55-65° C. to obtain a mixture;

[0029] S3. When the temperature of the mixture in S2 drops to 35-45° C., add the moisturizer, thickener, antiperspirant and deodorant composition solution and the remaining deionized water, stir evenly, and finally add the pH adjuster to obtain the roll-on liquid.

[0030] Compared with the prior art, the present invention has the following beneficial effects:

[0031] The Sophora flavescens root extract and the Hedyotis diffusa herb extract in the deodorizing and antiperspirant composition of the present invention have a synergistic effect, which weakens the promoting effect of androgens on apocrine sweat glands by inhibiting the conversion of testosterone to DHT and the binding of DHT to androgen receptors. The sage extract reduces the secretion of eccrine sweat glands by inhibiting cholinergic receptors. The reasonable combination of the three ingredients can inhibit both sweat glands and enhance the antiperspirant effect; the reasonable combination of the Sophora flavescens root extract, the Hibiscus sabdariffa flower extract and the Ophiopogon japonicus root extract can better exert the antibacterial effect from the aspects of broad-spectrum antibacterial, regulating the living environment of microorganisms, and anti-inflammatory; the reasonable combination of the above ingredients can achieve the purpose of deodorization from the two aspects of inhibiting antiperspirant and antibacterial, and specifically regulate the influence of androgens on sweating, and is more suitable for addition to men's products. DETAILED DESCRIPTION

[0032] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0033] The sources of the raw materials used in the following examples and comparative examples are as follows:

[0034] Sophora flavescens root extract: manufacturer is Xi'an Jinheng Chemical Co., Ltd.

[0035] Hedyotis diffusa extract: manufactured by Draco Natural Products;

[0036] Sage extract: The manufacturer is Shaanxi Haolin Biotechnology Co., Ltd.

[0037] Roselle flower extract: manufactured by Xi'an Feida Biotechnology Co., Ltd.

[0038] Ophiopogon root extract: The manufacturer is Dongsheng Shengkang (Shaanxi) Biotechnology Co., Ltd.

[0039] Unless otherwise specified, other materials, reagents, etc. used in the Examples and Comparative Examples can be obtained from commercial sources.

[0040] Example 1

[0041] A deodorant and antiperspirant composition comprising a Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract in a weight ratio of 0.5:0.3:0.2:0.2:0.1. The total weight of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract is 100 parts by weight.

[0042] Example 2

[0043] A deodorant and antiperspirant composition comprising a Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract in a weight ratio of 0.4:0.2:0.1:0.1:0.05. The total weight of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract is 100 parts by weight.

[0044] Example 3

[0045] A deodorant and antiperspirant composition comprising a Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract in a weight ratio of 0.6:0.4:0.3:0.3:0.15. The total weight of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract is 100 parts by weight.

[0046] Example 4

[0047] A deodorant and antiperspirant composition comprising a Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract in a weight ratio of 0.1:0.5:0.05:0.05:0.5. The total weight of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract is 100 parts by weight.

[0048] Example 5

[0049] A deodorant and antiperspirant composition comprising a Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract in a weight ratio of 1:0.1:0.5:0.01:0.05. The total weight of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract is 100 parts by weight.

[0050] Example 6

[0051] A deodorant and antiperspirant composition comprising a Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract in a weight ratio of 0.05:1:0.01:2:0.01. The total weight of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract is 100 parts by weight.

[0052] Example 7

[0053] A deodorant and antiperspirant composition comprising a Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract in a weight ratio of 2:0.01:1:0.005:1. The total weight of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract, and Ophiopogon japonicus root extract is 100 parts by weight.

[0054] Comparative Example 1

[0055] The difference between Comparative Example 1 and Example 1 is that: Comparative Example 1 does not add Sophora flavescens root extract, and uses Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract and Ophiopogon root extract in a weight ratio of 0.3:0.2:0.2:0.1 to make up for the missing amount.

[0056] Comparative Example 2

[0057] The difference between Comparative Example 2 and Example 1 is that: Comparative Example 2 does not add Hedyotis diffusa extract, and uses Sophora flavescens root extract, Sage extract, Hibiscus sabdariffa flower extract and Ophiopogon root extract in a weight ratio of 0.5:0.2:0.2:0.1 to make up for the missing amount.

[0058] Comparative Example 3

[0059] The difference between Comparative Example 3 and Example 1 is that: Comparative Example 3 does not add sage extract, and uses Sophora flavescens root extract, Hedyotis diffusa extract, Hibiscus sabdariffa flower extract and Ophiopogon root extract in a weight ratio of 0.5:0.2:0.2:0.1 to make up for the missing amount.

[0060] Comparative Example 4

[0061] The difference between Comparative Example 4 and Example 1 is that: Comparative Example 4 does not add Roselle flower extract, and uses Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract and Ophiopogon root extract in a weight ratio of 0.5:0.3:0.2:0.1 to make up for the missing amount.

[0062] Comparative Example 5

[0063] The difference between Comparative Example 5 and Example 1 is that: Comparative Example 5 does not add Ophiopogon root extract, and uses Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract and Hibiscus sabdariffa flower extract in a weight ratio of 0.5:0.3:0.2:0.2 to make up for the missing amount.

[0064] Test Example 1: Inhibition Zone Test

[0065] 1. Preparation before the experiment

[0066] 1.1 Material preparation

[0067] Filter paper: 6mm diameter circular qualitative filter paper (sterilized at 121℃ for 30min, dried and sealed)

[0068] Sample solution: Accurately weigh the example / comparative example sample and prepare it to a 1% concentration (w / v) with sterile physiological saline, and sterilize it with a 0.22 μm filter membrane;

[0069] Culture medium: Nutrient agar medium (need to verify sterility, maintain 45-50℃ water bath after melting)

[0070] Bacterial suspension: Staphylococcus aureus ATCC 25923 standard strain, fresh culture within 3 generations, adjusted to 0.5 McFarland turbidity (about 1.5×10 8 CFU / mL)

[0071] 1.2 Equipment Calibration

[0072] The biosafety cabinet was turned on for UV disinfection 30 minutes in advance, the vernier caliper was calibrated to 0.01mm, and the constant temperature incubator was verified (37±1℃).

[0073] 2. Sample processing

[0074] In a biosafety cabinet, use a sterile pipette to add 20 μL of sample solution to the sterilized filter paper. After standing for 2 minutes, place it flat in a sterile dish (in a single layer to avoid overlapping), and then dry it in a 37°C hot air drying oven to constant weight.

[0075] 3. Preparation of inoculation medium

[0076] Pour 15-18 mL of nutrient agar (thickness 4 mm ± 0.5 mm) into each plate, let it stand horizontally for 30 minutes to solidify, and mark the plate number and operation date.

[0077] 4. Bacterial liquid coating

[0078] Dip a sterile cotton swab in the bacterial suspension and spread it evenly on the agar surface in a "Z" shape three times, rotating the plate 60° each time to ensure that the bacterial layer coverage is greater than 95%. Open the lid and dry at room temperature for 5 minutes.

[0079] 5. Place the filter paper

[0080] Place four experimental groups and one blank control (filter paper discs treated with sterile saline) on each plate in a "cross" pattern, with the distance between each disc ≥24 mm and the distance from the edge of the dish ≥15 mm. Use sterile tweezers to grasp the edge of the disc and release it immediately after lightly touching the culture medium.

[0081] 6. Cultivation and Observation

[0082] The filter paper was placed upright in a 37°C incubator for 17 h.

[0083] 7. Outcome Measurement

[0084] After the incubation period, remove the plate and measure the diameter of the inhibition ring (accurate to 0.1 mm) using a vernier caliper under natural light or a colony counter. The diameters of two perpendicular directions should be measured perpendicularly through the center of the ring. The average value is used as the inhibition ring diameter for the plate and the data is recorded. For the blank control plate, no inhibition ring should appear. If an inhibition ring appears, it indicates possible contamination during the experiment and the experiment needs to be repeated. See Table 1 for details.

[0085] Table 1 Inhibition zone diameter data of each group of samples

[0086] sample Diameter of inhibition zone (mm) Example 1 16.7 Example 2 15.4 Example 3 16.2 Example 4 14.7 Example 5 15.6 Example 6 13.9 Example 7 15.0 Comparative Example 1 5.1 Comparative Example 2 8.4 Comparative Example 3 9.6 Comparative Example 4 6.9 Comparative Example 5 7.2

[0087] As can be seen from Table 1, combining the data of Example 1 with Examples 2-7 and Comparative Examples 1-5, it can be seen that the ingredients that affect the antibacterial properties of the composition are, from largest to smallest, Sophora flavescens root extract, Hibiscus sabdariffa flower extract, Ophiopogon japonicus root extract, Hedyotis diffusa extract and Sage extract. Sophora flavescens root extract plays the main antibacterial effect, but the combination of Sophora flavescens root extract, Hibiscus sabdariffa flower extract, Ophiopogon japonicus root extract, Hedyotis diffusa extract and Sage extract can synergistically enhance the antibacterial effect.

[0088] Test Example 2: Test of the inhibitory ability of the composition on 5α-reductase

[0089] 1. Reagent preparation

[0090] Sample solution: Accurately weigh an appropriate amount of the composition of the embodiment or comparative example and use ultrapure water to prepare a 2% aqueous solution. During the preparation process, accurately weigh using an electronic balance (accuracy 0.0001g) and stir thoroughly with a magnetic stirrer until completely dissolved. After the solution is prepared, store it in a refrigerator at 4°C for later use.

[0091] PBS solution: According to the PBS buffer formula, accurately weigh sodium chloride, potassium chloride, disodium hydrogen phosphate, potassium dihydrogen phosphate and other reagents, dissolve them in ultrapure water and make up to volume, adjust the pH to 7.3, and sterilize by high-pressure steam (121°C, 20 minutes) before use.

[0092] NADPH solution: Prepare a 2 mM solution using PBS at pH 7.3.

[0093] Testosterone solution: a 0.83 nM solution prepared in 75% ethanol;

[0094] Positive control solution: Weigh finasteride and prepare a 2.5 mmol / L solution using a suitable solvent.

[0095] 2. Enzyme solution preparation

[0096] Remove the lyophilized 5α-reductase powder from the -80°C freezer and dissolve and dilute it using the specified buffer according to the instructions to prepare the enzyme solution at the desired concentration. Store the enzyme solution in an ice bath to prevent prolonged exposure to room temperature, which can lead to a decrease in enzyme activity.

[0097] 3. Instrument preparation

[0098] Preheat the microplate reader in advance for at least 30 minutes to ensure the instrument reaches a stable operating state. Also, check the temperature accuracy of the 37°C incubator. Calibrate with a standard thermometer, keeping the error within ±0.5°C. Prepare consumables such as test tubes, a sterilized pipette (equipped with 100μL and 1mL tips), and a 96-well microplate (sterile, transparent).

[0099] 4. Sample tube operation

[0100] Add 1 mL of each group of example and comparative example sample solution, 1 mL of enzyme solution, 1 mL of NADPH solution and 1 mL of testosterone solution to the test tube, shake gently to obtain a mixed liquid, take 200 μL of the mixed liquid into a 96-well microplate with a pipette, make three parallels for each sample, put it into the microplate reader for detection, and measure the absorbance value at 340 nm, which is the first measured value A 样品0 After the sample was incubated at 37°C for 20 minutes, it was placed in a microplate reader for detection and the absorbance value at 340 nm was measured as the second measurement value A. 样品20 .

[0101] 5. Enzyme tube operation

[0102] Add 1 mL of PBS solution, 1 mL of enzyme solution, 1 mL of NADPH solution, and 1 mL of testosterone solution to a test tube, shake gently to obtain a mixed liquid, and use a pipette to take 200 μL of the mixed liquid into a 96-well microplate. Make three replicates for each sample, place it in a microplate reader for detection, and measure the absorbance at 340 nm, which is the first measured value A. 酶0 After the sample was incubated at 37°C for 20 minutes, it was placed in a microplate reader for detection and the absorbance value at 340 nm was measured as the second measurement value A. 酶20 ; At the same time, blank and positive control tests were performed, wherein the blank control group was replaced with an equal amount of deionized water in the sample tube, and the positive control group was 1 mL of 2.5 mmol / L finasteride solution, and the steps were the same as above;

[0103] 6. Calculation of inhibition rate

[0104] The calculation formula of inhibition rate is: The data of each group are shown in Table 2.

[0105] Table 2 5-α reductase inhibition rate data of each group of samples

[0106] sample 5-α-reductase inhibition rate / % Example 1 54.5 Example 2 50.6 Example 3 53.7 Example 4 42.2 Example 5 47.4 Example 6 40.4 Example 7 45.4 Comparative Example 1 15.0 Comparative Example 2 16.2 Comparative Example 3 17.9 Comparative Example 4 21.7 Comparative Example 5 22.5 Positive control group 71.5

[0107] As shown in Table 2, 5-α-reductase is an enzyme that promotes the conversion of testosterone to dihydrotestosterone (DHT), which is closely related to overactivity of the sebaceous glands. A higher 5-α-reductase inhibition rate indicates that the sample has better androgen inhibition performance.

[0108] Combining the data of Example 1 and Comparative Examples 1-5, it can be seen that the ingredients in the composition that affect androgen conversion are, from largest to smallest, Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract and Ophiopogon japonicus root extract. However, the combination of Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract and Ophiopogon japonicus root extract can synergistically inhibit the conversion of androgens and avoid stimulating sweat glands.

[0109] Combining the data of Example 1 and Examples 2-7, it can be seen that when the weight ratio of Sophora flavescens root extract, Hedyotis diffusa extract, Salvia officinalis extract, Hibiscus sabdariffa flower extract and Ophiopogon japonicus root extract is (0.4-0.6):(0.2-0.4):(0.1-0.3):(0.1-0.3):(0.05-0.15), the 5-α-reductase inhibition rate is at a good level.

[0110] Application Examples 1-7 and Comparative Application Examples 1-5

[0111] Application Examples 1-7 and Comparative Application Examples 1-5

[0112] The compositions of Examples 1-7 and Comparative Examples 1-5 were added to roll-on liquids at a concentration of 5 wt % to obtain roll-on liquids of Application Examples 1-7 and Comparative Application Examples 1-5. The formulas are shown in Table 3.

[0113] The preparation method of the roll-on liquid of Application Examples 1-7 and Comparative Application Examples 1-5 comprises the following steps:

[0114] The preparation method of the roll-on solution comprises the following steps:

[0115] S1. Adding pure water in an amount 5 times the total mass of each component to each component of the antiperspirant and deodorant composition and mixing with stirring to obtain an antiperspirant and deodorant composition solution;

[0116] S2. Mixing the preservative with 1 / 2 amount of deionized water and dissolving the mixture at 60° C. to obtain a mixture;

[0117] S3. When the temperature drops to 40° C., add the moisturizer, thickener, antiperspirant and deodorant composition solution and the remaining deionized water, stir evenly, and finally add the pH adjuster to obtain the roll-on liquid.

[0118] Table 3 Roll-on liquid formulas for application examples 1-7 and comparative application examples 1-5

[0119]

[0120] Comparative Application Example 6

[0121] The roll-on liquid of comparative application example 6 does not contain the antiperspirant and deodorant composition, but uses an equal amount of deionized water instead of the composition. The preparation method is the same as that of application example 1.

[0122] Test Example 3: Roll-on test on human armpits

[0123] 1. Eligibility criteria:

[0124] (1) Males aged 18-45 years with bromhidrosis grade 1 or above (according to the bromhidrosis grading method in the Expert Consensus on Botulinum Toxin Injection Treatment for Hyperhidrosis and Bromhidrosis);

[0125] (2) no history of axillary surgery and no use of other antiperspirant / antibacterial products for more than 7 days;

[0126] (3) No axillary skin damage, allergic diseases or systemic diseases (such as diabetes, liver and kidney dysfunction).

[0127] 65 males who met the above conditions were screened and randomly divided into 13 groups, with 5 people in each group.

[0128] 2. Grouping and Sample Size

[0129] Experimental group: using the roll-on solutions of Application Examples 1-7 and Comparative Application Examples 1-6;

[0130] Blank group: The subjects did not use any product on their right armpit as a blank control group;

[0131] 3. Deodorization effect test steps

[0132] Odor intensity was scored using the Wild II method, with five trained odorists independently scoring in a blind evaluation. The scoring criteria are shown in Table 4.

[0133] Table 4 Wild II scoring criteria

[0134] score Degree of odor 0 Odorless 1 Threshold odor 2 Very faint odor 3 Light odor 4 Light to medium odor 5 Medium odor 6 Slightly strong odor 7 Moderate strong odor 8 Strong odor 9 Very strong odor 10 Very strong odor

[0135] Baseline score: On day 0 (before the first use), the volunteers stretched out their arms, and the odorist evaluated the odor of both sides of the armpits and recorded the average score (S 前 ).

[0136] Final scoring: After the sweat collection on the 14th test day, the same group of odorists re-evaluated the left axillary odor (S 后), and the right axilla served as the baseline control.

[0137] Deodorization rate calculation: Deodorization rate (%) = (S 后 -S 前 ) / S 前 ×100%; see Table 5 for specific data.

[0138] 4. Antiperspirant effect test steps

[0139] Preliminary preparation

[0140] Special pad processing: sterile cotton fiber pads (5cm×5cm) were used, and each pad was weighed with an electronic balance (accuracy 0.001g) to record the initial mass (recorded as m 前左 、m 前右 ), sealed and individually packaged for sterilization.

[0141] Product Usage Instructions: Apply 0.3g of sample evenly to the left armpit (right armpit blank control) once in the morning and evening each day for 14 consecutive days; do not use other antiperspirant / deodorant products during use, and avoid spicy food and strenuous exercise.

[0142] Test Day Process

[0143] Cleansing and pretreatment: On the morning of the 15th day, wash both armpits with unscented neutral shower gel (such as Cetaphil), rinse with warm water and blow dry with cold air; reapply the sample once to the left armpit and leave the right armpit untreated.

[0144] Pad installation and sweat collection: Place the pre-weighed pads against the armpits and secure with breathable tape to ensure complete coverage of the sweat gland area. Place the subjects in a constant temperature chamber (temperature 38°C ± 1°C, humidity 35% ± 5% RH) and sit still for 60 minutes (no extensive limb movement).

[0145] Quantitative analysis of sweat:

[0146] Weigh immediately after removing the gasket (recorded as m 后左 、m 后右 );

[0147] The test formula for antiperspirant rate is: See Table 5 for specific data.

[0148] Table 5 Deodorization rate and antiperspirant rate data of each group of samples

[0149]

[0150]

[0151] As shown in Table 5, the main deodorizing and antiperspirant ingredients of the roll-on liquid of the present invention are Sophora flavescens root extract, Hedyotis diffusa extract, Hibiscus sabdariffa flower extract, Ophiopogon japonicus root extract, and Sage extract. These five ingredients synergistically reduce the secretion of eccrine and apocrine sweat glands to achieve the purpose of antiperspirant, and reduce the growth of axillary flora by inhibiting bacteria and changing the bacterial growth environment. The combined antiperspirant and antibacterial effects achieve the purpose of deodorization. At the same time, because the composition can effectively inhibit androgens, it is more suitable for men.

[0152] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. An antiperspirant and deodorant composition, characterized in that: The invention comprises the following components: sophora flavescens root extract, hedyotis diffusa extract, sage extract, roselle flower extract and ophiopogon root extract, wherein the weight ratio of the sophora flavescens root extract, hedyotis diffusa extract, sage extract, roselle flower extract and ophiopogon root extract is (0.05-2): (0.01-1): (0.01-1): (0.005-2): (0.01-1).

2. The antiperspirant and deodorant composition according to claim 1, wherein The weight ratio of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract and Ophiopogon japonicus root extract is (0.1-1): (0.1-0.5): (0.05-0.5): (0.01-0.05): (0.05-0.5).

3. The antiperspirant and deodorant composition according to claim 1, wherein The weight ratio of the Sophora flavescens root extract, Hedyotis diffusa extract, Sage extract, Hibiscus sabdariffa flower extract and Ophiopogon japonicus root extract is (0.4-0.6): (0.2-0.4): (0.1-0.3): (0.1-0.3): (0.05-0.15).

4. Use of the antiperspirant and deodorant composition according to any one of claims 1 to 3 in the preparation of men's products.

5. Use of the antiperspirant and deodorant composition according to claim 4 in preparing men's products, characterized in that: The men's product is a spray, a roll-on liquid, a gel, a gel or a wet wipe, and the added amount of the composition is 1%-10% of the total weight of the men's product.

6. A roll-on liquid, characterized in that: The invention comprises the following raw materials in weight percentage: 1%-10% of the antiperspirant and deodorant composition according to any one of claims 1 to 3, 4%-14% of a moisturizer, 0.5%-3% of a preservative, 0.01%-0.05% of a thickener, and 0.01%-0.3% of a pH regulator, with the balance being deionized water.

7. The roll-on liquid according to claim 8, wherein: The raw material is selected from at least one of (a) to (d): (a) the humectant is glycerol and / or sorbitol; (b) the preservative comprises at least one of 1,3-propylene glycol, 1,2-hexanediol and p-hydroxyacetophenone; (c) the thickener is xanthan gum; (d) The pH regulator is EDTA-disodium.

8. The method for preparing the roll-on liquid according to claim 7, characterized in that: The following steps are involved: S1. Adding 4-6 times the total mass of water to each component of the antiperspirant and deodorant composition and mixing with stirring to obtain an antiperspirant and deodorant composition solution; S2. mixing the preservative and a portion of deionized water, and dissolving the mixture at 55-65° C. to obtain a mixture; S3. When the temperature of the mixture in S2 drops to 35-45° C., add the moisturizer, thickener, antiperspirant and deodorant composition solution and the remaining deionized water, stir evenly, and finally add the pH adjuster to obtain the roll-on liquid.

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