Multi-functional tooth desensitizer and method of making same

Abstract

This invention discloses a multifunctional tooth desensitizing agent and its preparation method, belonging to the field of medical devices. The main components of the multifunctional tooth desensitizing agent prepared by this invention include: gallnut water extract, ethyl acetate, *Sanguisorba officinalis* extract, *Sophora flavescens* extract, hydroxymethyl chitosan, thymol, sodium carboxymethyl cellulose, and mannitol. Currently, oral health issues are receiving increasing attention. This invention aims to address the current imbalance in the oral microecology, where plaque accumulation easily leads to demineralization of tooth hard tissues, subsequently causing caries and tooth sensitivity. Furthermore, existing products have limited effects and cannot simultaneously achieve remineralization, desensitization, caries prevention, and plaque prevention. The multifunctional tooth desensitizing agent prepared by this invention is neutral and non-irritating, and can inhibit oral plaque growth and accumulation while simultaneously providing desensitization, remineralization, and caries prevention effects.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a multifunctional tooth desensitizing agent and its preparation method. Background Technology

[0002] With the continuous improvement of living standards, oral health issues are receiving increasing attention. Common dental conditions include: 1) Tooth sensitivity: Also known as dentin hypersensitivity, tooth sensitivity occurs when enamel is damaged, exposing the dentin. Mechanical, chemical, or temperature stimuli cause fluid flow within the dentinal tubules, resulting in specific symptoms such as acidity, tenderness, and pain. Tooth demineralization: Demineralization reduces tooth hardness, leaving cavities on the enamel surface and a loose structure. 2) Tooth decay: Dental caries is a chronic, progressive destructive disease of the hard tissues of the teeth caused by bacterial infection. It is the most common oral disease in humans, usually associated with the overgrowth of major cariogenic bacteria such as Streptococcus mutans and Actinobacter myxobolus. The adhesion of cariogenic bacteria to the tooth surface easily leads to demineralization of the hard tissues of the teeth, subsequently causing caries. The effectiveness of caries prevention is usually reflected in inhibiting the growth, acid production, sugar production, and adhesion of cariogenic bacteria and their biofilms. 3) Plaque buildup: When the oral microecology is imbalanced, bacteria and microorganisms deposit, adhere, and grow, thus forming plaque biofilm on the surface of teeth and biomaterials. This produces pathogenic substances that act on the local oral microenvironment and induce disease.

[0003] The causes of dental-related diseases can be broadly described as follows: when the oral microecology is imbalanced and plaque accumulates, it easily leads to demineralization of the hard tissues of the teeth, subsequently causing tooth decay and tooth sensitivity. Furthermore, existing products offer only one effect and cannot simultaneously satisfy the functions of remineralization, desensitization, caries prevention, and plaque prevention. Therefore, there is an urgent need for a comprehensive, fast-acting, and effective tooth desensitizing agent to address these issues. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a multifunctional tooth desensitizer and its preparation method, which can inhibit the growth of oral plaque while achieving desensitization and remineralization effects.

[0005] The technical solution to achieve the objective of this invention is:

[0006] A multi-functional tooth desensitizer, comprising the following components by weight percentage:

[0007] Gallnut water extract accounts for 1-3 wt.%, ethyl acetate accounts for 0.1-0.5 wt.%, Sanguisorba officinalis extract accounts for 2-3 wt.%, Sophora flavescens extract accounts for 1-5 wt.%, hydroxymethyl chitosan accounts for 0.2-0.5 wt.%, thymol accounts for 1-5 wt.%, sodium carboxymethyl cellulose accounts for 5-15 wt.%, mannitol accounts for 0.5-1 wt.%, zinc ion exchange agent accounts for 4-6 wt.%, and the remainder is made up with deionized water.

[0008] This invention combines extracts from three Chinese medicinal herbs (with active ingredients including gallic acid and methyl gallate) with zinc ions to provide multi-effect tooth protection. It also provides comprehensive tooth remineralization, desensitization, anti-caries, and anti-plaque effects, offering a new approach in the industry. Furthermore, it pays attention to details and considers the overall pH environment. Subsequent experiments have shown that the improvement effect is significant.

[0009] Furthermore, the zinc ion exchange agent is zinc chloride.

[0010] Furthermore, the overall pH value of the multifunctional tooth desensitizer is controlled at 7.

[0011] A method for preparing a multifunctional tooth desensitizing agent, the method comprising the following steps:

[0012] (1) Take the quantities of each component according to the formula;

[0013] (2) First, take the water extract of gallnut, ethyl acetate, extract of sanguisorba officinalis, extract of sophora flavescens, hydroxymethyl chitosan and thymol and dissolve them in deionized water. Mix and stir evenly at 45-60℃ to obtain the matrix solution.

[0014] (3) Add sodium carboxymethyl cellulose and mannitol to the matrix solution and mix well. Then add a pH adjuster to adjust to neutral and load zinc ions to obtain a multifunctional tooth desensitizer. By adjusting the system environment of zinc ions to neutral and stirring, flocculation is avoided, thus optimizing the antibacterial effect.

[0015] Furthermore, in step (2), the stirring temperature is 45-60℃ and the mixing time is 30-50 min.

[0016] Furthermore, the pH adjuster in step (3) is a NaOH solution or an HCl solution.

[0017] By adopting the above technical solution, the present invention has the following beneficial effects:

[0018] The multifunctional tooth desensitizer prepared in this invention is neutral and non-irritating. It can inhibit the growth and accumulation of oral plaque while desensitizing, remineralizing, and preventing caries. The multifunctional tooth desensitizer prepared in this invention can interact with bacterial plasmid DNA, thereby changing the permeability and integrity of the bacterial cell membrane, preventing normal replication and transcription, inhibiting bacterial passage and growth, and thus preventing plaque accumulation. Detailed Implementation

[0019] A multi-functional tooth desensitizer comprising the following components by weight percentage:

[0020] Gallnut water extract (main components: gallic acid, methyl gallate) accounts for 1-3 wt.%, ethyl acetate accounts for 0.1-0.5 wt.%, Sanguisorba officinalis extract accounts for 2-3 wt.%, Sophora flavescens extract accounts for 1-5 wt.%, hydroxymethyl chitosan accounts for 0.2-0.5 wt.%, thymol accounts for 1-5 wt.%, sodium carboxymethyl cellulose accounts for 5-15 wt.%, mannitol accounts for 0.5-1 wt.%, zinc ion exchange agent accounts for 4-6 wt.%, and the remainder is made up with deionized water.

[0021] A method for preparing a multifunctional tooth desensitizing agent includes the following steps: measuring each component according to the above formula.

[0022] (1) First, take the water extract of gallnut, ethyl acetate, extract of sanguisorba officinalis, extract of sophora flavescens, hydroxymethyl chitosan and thymol and dissolve them in deionized water. Mix and stir at 45-60℃ for 30-50 minutes (avoid the formation of flocculent matter) to obtain the matrix solution.

[0023] (2) Take the base solution and add sodium carboxymethyl cellulose and mannitol to mix. Add a pH adjuster to neutral and load zinc ions to obtain a multifunctional tooth desensitizer. The zinc ion loading is achieved by adding zinc chloride. The pH adjuster is a 0.01 mol / L NaOH or HCl solution. Adjust the pH to neutral to ensure that zinc ions adhere to the bacterial cell wall in a neutral environment, inhibiting oral plaque growth.

[0024] Instructions for use: Use after scaling and root planing (Scaling and root planing: Clinically, gingival scaling and root planing can be divided into supragingival scaling and subgingival scaling, which can clean and remove tartar at the base of the gums and deep within the teeth, more thoroughly removing plaque and microorganisms from the oral cavity). Use a curved syringe to inject the product into the periodontal pocket of the treatment area, ensuring it covers the teeth, until slightly overflowing. Use a brush to apply the product to the tooth surface and leave it on for 20 minutes. Avoid vigorous rinsing, drinking, or eating during these 20 minutes. (For milder symptoms, the product can be applied directly to the tooth surface).

[0025] Example 1

[0026] A multi-functional tooth desensitizer comprising the following components by weight percentage:

[0027] The composition of the ingredients is as follows: Gallnut water extract 2 wt.%, ethyl acetate 0.3 wt.%, Sanguisorba officinalis extract 2.5 wt.%, Sophora flavescens extract 3 wt.%, hydroxymethyl chitosan 0.3 wt.%, thymol 3 wt.%, sodium carboxymethyl cellulose 10 wt.%, mannitol 0.8 wt.%, zinc ion exchange agent 5 wt.%, with the remainder made up with deionized water.

[0028] A method for preparing a multifunctional tooth desensitizing agent includes the following steps: measuring each component according to the above formula.

[0029] (1) First, take the water extract of gallnut, ethyl acetate, extract of sanguisorba officinalis, extract of sophora flavescens, hydroxymethyl chitosan and thymol and dissolve them in deionized water. Mix and stir evenly at 50°C to obtain the matrix solution.

[0030] (2) Take the base liquid and add sodium carboxymethyl cellulose and mannitol to mix. Add a pH adjuster to adjust to neutral and add a zinc ion agent to load zinc ions. This is a multifunctional tooth desensitizer.

[0031] Example 2

[0032] A multi-functional tooth desensitizer comprising the following components by weight percentage:

[0033] The composition of the ingredients is as follows: Gallnut water extract 1 wt.%, ethyl acetate 0.1 wt.%, Sanguisorba officinalis extract 2 wt.%, Sophora flavescens extract 1 wt.%, hydroxymethyl chitosan 0.2 wt.%, thymol 1 wt.%, sodium carboxymethyl cellulose 5 wt.%, mannitol 0.5 wt.%, zinc ion exchange agent 4 wt.%, with the remainder made up with deionized water.

[0034] A method for preparing a multifunctional tooth desensitizing agent includes the following steps: measuring each component according to the above formula.

[0035] (1) First, take the water extract of gallnut, ethyl acetate, extract of sanguisorba officinalis, extract of sophora flavescens, hydroxymethyl chitosan and thymol and dissolve them in deionized water. Mix and stir evenly at 45°C to obtain the matrix solution.

[0036] (2) Take the base liquid and add sodium carboxymethyl cellulose and mannitol to mix. Add a pH adjuster to adjust to neutral and add a zinc ion agent to load zinc ions. This is a multifunctional tooth desensitizer.

[0037] Example 3

[0038] A multi-functional tooth desensitizer comprising the following components by weight percentage:

[0039] The composition of the ingredients is as follows: Gallnut water extract 3 wt.%, ethyl acetate 0.5 wt.%, Sanguisorba officinalis extract 3 wt.%, Sophora flavescens extract 5 wt.%, hydroxymethyl chitosan 0.5 wt.%, thymol 5 wt.%, sodium carboxymethyl cellulose 15 wt.%, mannitol 1 wt.%, zinc ion exchange agent 6 wt.%, with the remainder made up with deionized water.

[0040] A method for preparing a multifunctional tooth desensitizing agent includes the following steps: measuring each component according to the above formula.

[0041] (1) First, take the water extract of gallnut, ethyl acetate, extract of sanguisorba officinalis, extract of sophora flavescens, hydroxymethyl chitosan and thymol and dissolve them in deionized water. Mix and stir evenly at 60°C to obtain the matrix solution.

[0042] (2) Take the base liquid and add sodium carboxymethyl cellulose and mannitol to mix. Add a pH adjuster to adjust to neutral and add a zinc ion agent to load zinc ions. This is a multifunctional tooth desensitizer.

[0043] Comparative Example 1: It is basically the same as Example 1, except that the pH value was not adjusted in step (2);

[0044] Comparative Example 2: Commercially available tooth desensitizers (main ingredients: sorbitol, hydrated vermiculite);

[0045] Evaluation: The products obtained from Examples 1-3, Comparative Example 1, and Comparative Example 2 were tested. The test was divided into 5 groups, with 10 people in each group (with similar disease severity). The plaque index (PI), gingival index (GI), and surface microhardness were measured, and the average values ​​were taken. The details are as follows:

[0046] Scoring method:

[0047] PI (Plaque Inspection): Plaque quantity is graded into 4 levels: 0 (no plaque in the gingival margin); 1 (no plaque upon visual inspection, but a thin layer of plaque can be scraped out with a probe in the free gingiva and adjacent areas); 2 (moderate amount of soft deposits visible in the gingival pocket, free gingiva, or adjacent tooth surfaces); 3 (large amount of soft deposits in the gingival pocket, free gingiva, or adjacent tooth surfaces).

[0048] GI: This test examines the condition of the gingival margin in four areas: mesial, distal, buccal, and lingual, and is graded from 0 to 3. 0 points (normal gingiva); 1 point (mild gingival inflammation, slight discoloration, mild edema, no bleeding on probe); 2 points (moderate gingival inflammation, red, edematous, shiny, bleeding on probe); 3 points (significant gingival inflammation, redness, swelling, ulceration, tendency to bleed spontaneously).

[0049] Surface microhardness test: (The samples used in this test were extracted teeth with similar surface microhardness. The test was divided into 5 groups, with 10 teeth in each group. The surface microhardness values ​​were measured, and the average value was taken as the score. The effect is reflected by the surface microhardness of the teeth.) The product was applied to the tooth surface with a brush once a day. On the 7th and 15th days, the teeth in each group were cleaned and tested. The teeth were tested using a Vickers hardness tester. The indenter applied a load of 0.49N (equivalent to a 50g load) to the enamel surface and held for 15 seconds.

[0050] The experimental results are shown in Tables 1, 2, and 3.

[0051] Table 1. Results of plaque index test for each group

[0052]

[0053] Table 2. Results of gingival index test in each group

[0054]

[0055]

[0056] Table 3. Results of tooth surface microhardness test for each group

[0057]

[0058] Based on the above experiments, Example 1 is the optimal example, demonstrating significant therapeutic effects. After treatment, the plaque index (PI), gingival index (GI), and surface microhardness were all within a good and acceptable range. Examples 2 and 3 were slightly inferior. Comparative Example 1 did not adjust the pH to neutral, resulting in a significantly worse antibacterial effect and a slower decrease in the plaque index, while the other two indicators were better. Comparative Example 2 used a commercially available tooth desensitizing agent, which had a good desensitizing effect, but its effect on the plaque index (PI) and surface microhardness was not significant.

[0059] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above descriptions are merely specific embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A multi-functional tooth desensitizer, characterized in that, Its composition by mass percentage is as follows: Gallnut water extract accounts for 1-3 wt.%, ethyl acetate accounts for 0.1-0.5 wt.%, Sanguisorba officinalis extract accounts for 2-3 wt.%, Sophora flavescens extract accounts for 1-5 wt.%, hydroxymethyl chitosan accounts for 0.2-0.5 wt.%, thymol accounts for 1-5 wt.%, sodium carboxymethyl cellulose accounts for 5-15 wt.%, mannitol accounts for 0.5-1 wt.%, zinc ion exchange agent accounts for 4-6 wt.%, and the remainder is made up with deionized water; The overall pH value of the multifunctional tooth desensitizer is controlled at 7.

2. The multifunctional tooth desensitizer according to claim 1, characterized in that: The zinc ion exchanger is zinc chloride.

3. A method for preparing a multifunctional tooth desensitizing agent as described in any one of claims 1 to 2, characterized in that: The preparation method includes the following steps: (1) Take the quantities of each component according to the formula; (2) First, take the water extract of gallnut, ethyl acetate, extract of sanguisorba officinalis, extract of sophora flavescens, hydroxymethyl chitosan and thymol and dissolve them in deionized water. Mix and stir evenly to obtain the matrix solution. (3) Add sodium carboxymethyl cellulose and mannitol to the base solution and mix well. Then add a pH adjuster to adjust to neutral and add a zinc ion agent to make a multifunctional tooth desensitizer.

4. The preparation method of the multifunctional tooth desensitizer according to claim 3, characterized in that: The stirring temperature in step (2) is 45-60℃, and the mixing time is 30-50 min.

5. The preparation method of the multifunctional tooth desensitizer according to claim 4, characterized in that: The pH adjuster in step (3) is a NaOH solution or an HCl solution.

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