Preparation and clinical application of Deyu large plaster

Abstract

The invention relates to the technical field of clinical application, and discloses preparation and clinical application of Deyu large plaster, the raw materials of the Deyu large plaster comprise fritillaria, deer sinew, honeysuckle and other medicinal materials, yellow lead and sesame oil are supplemented, and the Deyu large plaster is prepared through the steps of preparing and soaking, decocting, adding the yellow lead, removing fire toxin, removing mud, packaging and the like. In the medicinal materials, the fritillaria clears heat and moistens lung, the deer sinew nourishes liver and kidney and strengthens muscles and bones, and the honeysuckle has antibacterial and anti-inflammatory effects, and the medicines are compatible to achieve the effects of strengthening tendons and bones, nourishing blood and dredging collaterals. Clinically, 520 patients with neck, shoulder, waist and leg pain are divided into a treatment group (320 patients use Deyu large plaster) and a control group (200 patients use collateral dredging and pain relieving plaster), after 10 days of treatment course, 102 patients are cured in the treatment group, 131 patients are effective, the total effective rate is 94%, the total effective rate of the control group is 81%, and the difference between the two groups is remarkable (plt: 0.05). The plaster is small in adverse reaction, suitable for long-term use and remarkable in curative effect in treatment of neck-shoulder and lumbocrural pain.

Description

Technical Field

[0001] The present invention relates to the technical field of clinical application, in particular to the preparation and clinical application of Deyu plaster. Background Art

[0002] Neck, shoulder, waist and leg pain is a common health problem. The main sufferers are the elderly. The causes include chronic strain, joint degenerative diseases, nerve compression, etc. With the popularization of electronic products, the number of people suffering from neck, shoulder, waist and leg pain has increased year by year and is becoming younger. It involves multiple systems such as muscles, bones, nerves, and blood vessels. Common clinical causes include muscle strain, such as poor posture, overuse, acute strain, etc.; bone degenerative diseases, such as herniated disc, osteoarthritis, osteoporosis, etc.; joint dislocation or deformation, such as facet joint disorder, scoliosis, etc.; inflammatory diseases, such as ankylosing spondylitis, rheumatoid arthritis, etc.

[0003] Currently, Western medicine treatments primarily use nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and indomethacin. These drugs offer advantages such as rapid onset and excellent analgesic effects, but they also have significant side effects. Long-term use can damage gastrointestinal, liver, and kidney function, and their effects are unstable and prone to relapse, making them unsuitable for long-term use. Deyu Plaster, used externally, has minimal adverse reactions and can be used long-term without side effects, making it an ideal treatment on the market.

[0004] Deyu Plaster is made from extracts of Fritillaria, deer tendon, honeysuckle, Notopterygium wilfordii, Angelica dahurica, Sophora flavescens, cinnamon, yellow ochre, and vegetable oil. It has the effects of strengthening tendons and bones, nourishing blood and dredging meridians, producing essence and marrow, removing rheumatism, benefiting joints, and relieving pain. Deyu Plaster has been clinically verified for many years and has very good clinical efficacy. Summary of the Invention

[0005] In view of the deficiencies in the prior art, the present invention provides the preparation and clinical application of Deyu plaster.

[0006] To achieve the above object, the present invention provides the following technical solution: a preparation method of Deyu plaster, wherein the proportions of Deyu plaster are as follows: medicinal material raw materials: Fritillaria (6%); deer tendon (12%); honeysuckle (8%); Notopterygium root (6%), Angelica dahurica (4%), Chinese angelica (8%), Sophora flavescens (12%); cinnamon bark (8%); Mineral matrix part: yellow lead (12%); Emulsifying base: sesame oil (10%).

[0007] Preferably, the preparation method thereof is as follows: process flow: preparation → boiling → making the elixir → removing fire poison → tidal flat → packaging and storage; (1) Preparation: Weigh the Chinese medicinal materials according to the formula and pour them into the decoction pot and soak them in sesame oil for 5-7 days in spring and 7-10 days in autumn and winter; (2) Boiling: Heat the decoction pot to 150℃ and fry the herbs in the decoction pot. Stir the herbs in the decoction pot every half an hour. After 4 hours, raise the temperature of the decoction pot to 220℃. Fry the herbs in the decoction pot until they are dry. Remove the residue. (3) Adding the yellow ochre: Continue to heat the oil in the decocting pot to 300°C, and sprinkle the yellow ochre evenly into the pot. Stir the oil while adding the yellow ochre. (4) Remove fire poison: Pour the medicinal oil from the pill into the water to remove fire poison. Do this for 7 consecutive days, changing the water once a day. (5) Applying the ointment: Melt the ointment for removing fire poison and apply it on the plaster cloth according to the established specifications; (6) Packing and storage.

[0008] Preferably, in the formula, Fritillaria is used for clearing heat and moistening the lungs, resolving phlegm and relieving cough; deer tendon is used for nourishing the liver and kidneys and strengthening the bones and muscles; honeysuckle is used for antibacterial and anti-inflammatory, and evacuating wind-heat; Notopterygium and Angelica dahurica are used for dispelling wind and dampness, relieving numbness and relieving pain; Angelica sinensis and bitter melon are used for promoting blood circulation, nourishing blood, drying dampness and detoxifying; cinnamon is used for warming the meridians and dispersing cold, and promoting transdermal absorption; yellow lead is a mineral matrix used to enhance adhesion; and sesame oil is used for the emulsified matrix to resist oxidation.

[0009] Preferably, the specific steps of its preparation are: soaking the medicinal materials in sesame oil as a matrix for 7-10 days; Stone-ground sesame oil not only acts as a solvent, facilitating the dissolution of the active ingredients in the medicinal herbs, but also, due to its unique properties, interacts with the medicinal ingredients during the subsequent refining process, enhancing the efficacy of the plaster. During the soaking process, the active ingredients in the herbs gradually dissolve in the sesame oil, preparing them for subsequent extraction. Precise control of the soaking time is crucial: too short a time will result in inadequate dissolution of the active ingredients; too long a time may cause the ingredients to deteriorate, affecting the quality of the plaster.

[0010] Preferably, the specific steps of boiling are as follows: after the soaking is completed, entering the oil refining stage, using a gentle and strong fire to refine the oil, and controlling the heat and time; First, heat to 150°C over a low heat, then continue heating and stirring to allow the sesame oil to blend with the medicinal ingredients and initiate a complex chemical reaction. Then, high heat is used, that is, heating to 220°C, to quickly heat the sesame oil and medicinal materials, so that the water in the sesame oil evaporates quickly and the reaction activity of the medicinal materials and sesame oil is stimulated; The oil is refined until it forms beads. That is, if a drop of oil is dropped into cold water and the oil drop does not disperse but condenses into beads, it indicates that the oil refining has reached the ideal level.

[0011] Preferably, the specific steps of the oxidizing step are: after the oil is refined to a suitable degree, continue to heat it to 300°C, add yellow ochre to carry out the oxidizing step; Yellow ochre undergoes a saponification reaction with sesame oil at high temperature, converting the oil into a paste-like substance. During the making of the ochre, continuous stirring is required, and yellow ochre is added gradually to allow the yellow ochre to fully react with the oil and ensure that the paste is uniform.

[0012] Preferably, the specific steps of removing fire poison are: pouring the refined plaster into water in a thin stream and stirring vigorously to fully dissolve the irritant in the plaster in the water; When the washing water becomes hot, replace it with cold water in time. After it cools and condenses into a mass, immerse the mass in water and change the water several times for about 7 days until the paste has a mild medicinal property. Through the detoxification process, harmful substances in the plaster are effectively removed, ensuring its safety in clinical applications while retaining the effective medicinal properties of the medicinal materials.

[0013] Preferably, the specific steps of the plastering are: using a modern advanced plastering machine to spread the plaster, accurately controlling the weight of each plaster, ensuring that the amount of medicinal ingredients contained in each plaster is stable and consistent, thereby ensuring that the medicinal properties of each plaster are uniform and the efficacy is reliable.

[0014] Preferably, the preparation of Deyu Plaster is used for clinical application, and Deyu Plaster is used for treating neck, shoulder, waist and leg pain.

[0015] Preferably, 520 patients were randomly divided into two groups, 320 cases in the treatment group, treated with Deyu plaster external application; 200 cases in the control group, treated with Tongluo Qutong plaster external application, the course of treatment was 10 days; Results: In the treatment group, 102 cases were cured, 131 cases were markedly effective, 68 cases were effective, and 19 cases were ineffective, with an overall effective rate of 94%; In the control group, 49 cases were cured, 41 cases were markedly effective, 72 cases were effective, 38 cases were ineffective, and the total effective rate was 81%; Conclusion: There was significant difference in the total effective rate between the two groups (p<0.05).

[0016] Compared with the prior art, the present invention provides the preparation and clinical application of Deyu plaster, which has the following beneficial effects: 1. The preparation and clinical application of the Deyu plaster. The deer tendon in the prescription can strengthen the tendons and bones, nourish the blood and dredge the meridians, produce essence and benefit the marrow. It has significant effects on long-term rheumatism, joint pain, back pain, fatigue or weakness of the tendons and bones, difficulty walking, weakness in the hands and feet, cramps in the hands and feet, injuries from falls, and sore tendons and bones. Notopterygium wilfordii and Angelica dahurica are the main anti-rheumatic drugs in the prescription. Notopterygium wilfordii is good at treating rheumatic pain in the upper body, while Angelica dahurica is better for rheumatic pain in the lower body. The two are complementary to each other, can disperse wind and dampness, dredge the joints, and have a good therapeutic effect on symptoms such as pain and numbness caused by rheumatic blockage of the meridians in the neck, shoulders, waist, and legs. Honeysuckle has the effect of clearing away heat and detoxifying. , dispersing wind-heat, on the one hand, it can clear away heat and toxins from the skin surface, prevent rheumatism from turning into heat, on the other hand, for those with neck, shoulder, waist and leg pain accompanied by local redness, swelling, heat and pain, it can play a role in clearing away heat, reducing swelling and relieving pain, and it can restrain the warm and dry nature of other medicines, so that the whole prescription is nourishing but not stagnant, warm but not dry; Angelica is a commonly used blood-activating and blood-tonifying medicine, which has the effects of promoting blood circulation, regulating menstruation, relieving pain, and moistening the intestines. It can nourish blood and activate blood circulation, so that qi and blood can flow smoothly, and there will be no pain. It can relieve pain caused by qi and blood stasis in neck, shoulder, waist and leg pain, and at the same time nourish blood to nourish tendons and veins, which helps to improve symptoms such as numbness of limbs and difficulty in flexion and extension; Fritillaria clears heat and resolves phlegm, disperses nodules and reduces swelling In the treatment of neck, shoulder, waist and leg pain, it can be used to relieve pain, lumps and other symptoms caused by phlegm and dampness blocking the meridians. When used with other medicines, it helps to dissipate local knots and improve the circulation of qi and blood; Sophora flavescens clears away heat and dampness, kills insects and relieves itching, and can assist honeysuckle in clearing away damp-heat evil, and has a certain relieving effect on symptoms such as redness, swelling, heat and pain in the joints, and itchy skin caused by rheumatic heat arthritis. At the same time, it can prevent damp-heat from settling and aggravating the condition; Cinnamon bark is pungent, sweet and very hot, and can replenish fire and assist yang, dispel cold and relieve pain, and warm and dredge the meridians. Its warming and dredging power can help Chinese angelica, Notopterygium wilfordii and other medicines to better warm and dredge the blood, dispel cold and relieve pain, and can warm and dredge the meridians for those with neck, shoulder, waist and leg pain caused by stagnation of cold evil. It has the effects of dispersing cold, unblocking meridians and relieving pain, dispersing cold evil, restoring Yang Qi, and promoting smooth blood circulation; Huang Dan has the effects of detoxifying and promoting tissue regeneration, absorbing moisture and relieving itching, and removing toxins and removing rot when applied externally. In plasters, it can promote local blood circulation, improve tissue nutrition, and contribute to the penetration and absorption of drugs. At the same time, it has a certain therapeutic effect on local sores, swellings, and skin damage, and can promote wound healing, relieve pain and inflammatory reactions; vegetable oil, as the matrix of the plaster, has the effects of moisturizing the skin and harmonizing various drugs, so that various drugs can be evenly mixed, easy to apply and absorb, and at the same time, it can also protect the skin and reduce the irritation of drugs to the skin. The combination of the above drugs has the effects of dispelling wind and dampness, clearing away heat and detoxifying, activating blood circulation and relieving pain, relaxing muscles and tendons, and dispersing knots, and has a good clinical effect on neck, shoulder, waist and leg pain.

[0017] 2. The preparation and clinical application of the Deyu Plaster, with its efficient transdermal absorption system: sesame oil is rich in over 80% unsaturated fatty acids. During the high-temperature boiling and reaction with yellow lead, it forms a micron-sized latex particle structure, which greatly increases the specific surface area of ​​the drug molecules. This allows the drug to more effectively penetrate the skin when in contact with the skin, allowing the drug to reach the lesion faster and deeper, fully exerting its efficacy. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 is a process flow chart of the present invention; Figure 2 A statistical table of clinical treatment results of the present invention; Figure 3 This is a clinical treatment flow chart of the present invention. DETAILED DESCRIPTION

[0019] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0020] See also Figure 1-Figure 3 The preparation method of Deyu plaster is as follows: the proportion of medicinal materials: Fritillaria 6%; Deer tendon 12%; Honeysuckle 8%; Notopterygium 6%; Angelica dahurica 4%; Angelica sinensis 8%; Sophora flavescens 12%; Cinnamon bark 8%; Mineral matrix part: yellow lead 12%; Emulsifying base: sesame oil 10%.

[0021] The preparation method is as follows: process flow: preparation → boiling → making pills → removing fire poison → slurry → packaging and storage; (1) Preparation: Weigh the Chinese medicinal materials according to the formula and pour them into the decoction pot and soak them in sesame oil for 5-7 days in spring and 7-10 days in autumn and winter; (2) Boiling: Heat the decoction pot to 150℃ and fry the herbs in the decoction pot. Stir the herbs in the decoction pot every half an hour. After 4 hours, raise the temperature of the decoction pot to 220℃. Fry the herbs in the decoction pot until they are dry. Remove the residue. (3) Adding the yellow ochre: Continue to heat the oil in the decocting pot to 300°C, and sprinkle the yellow ochre evenly into the pot. Stir the oil while adding the yellow ochre. (4) Remove fire poison: Pour the medicinal oil from the pill into the water to remove fire poison. Do this for 7 consecutive days, changing the water once a day. (5) Applying the ointment: Melt the ointment for removing fire poison and apply it on the plaster cloth according to the established specifications; (6) Packing and storage.

[0022] In its formula, Fritillaria is used to clear heat and moisten the lungs, resolve phlegm and relieve cough; deer tendon is used to nourish the liver and kidneys and strengthen the bones and muscles; honeysuckle is used for antibacterial and anti-inflammatory purposes, and to dispel wind-heat; Notopterygium and Angelica dahurica are used to dispel wind and dampness, relieve numbness and relieve pain; Angelica sinensis and bitter melon are used to promote blood circulation, replenish blood, dry dampness and detoxify; cinnamon is used to warm the meridians and dispel cold, and promote transdermal absorption; yellow lead is used as a mineral matrix to enhance adhesion; and sesame oil is used in the emulsified matrix for antioxidant properties.

[0023] The specific steps of its preparation are: soaking the medicinal materials in sesame oil as a matrix for 7-10 days; Stone-ground sesame oil not only acts as a solvent, facilitating the dissolution of the active ingredients in the medicinal herbs, but also, due to its unique properties, interacts with the medicinal ingredients during the subsequent refining process, enhancing the efficacy of the plaster. During the soaking process, the active ingredients in the herbs gradually dissolve in the sesame oil, preparing them for subsequent extraction. Precise control of the soaking time is crucial: too short a time will result in inadequate dissolution of the active ingredients; too long a time may cause the ingredients to deteriorate, affecting the quality of the plaster.

[0024] The specific steps of its brewing are: after the soaking is completed, it enters the oil refining stage, using soft and hard fire to refine the oil, controlling the heat and time; First, heat to 150°C over a low heat, then continue heating and stirring to allow the sesame oil to blend with the medicinal ingredients and initiate a complex chemical reaction. Then, high heat is used, that is, heating to 220°C, to quickly heat the sesame oil and medicinal materials, so that the water in the sesame oil evaporates quickly and the reaction activity of the medicinal materials and sesame oil is stimulated; The oil is refined until it forms beads. That is, if a drop of oil is dropped into cold water and the oil drop does not disperse but condenses into beads, it indicates that the oil refining has reached the ideal level.

[0025] When the oil is refined to a suitable degree, continue to heat it up to 300℃ and add yellow ochre to start the ochre reduction operation; Yellow ochre undergoes a saponification reaction with sesame oil at high temperature, converting the oil into a paste-like substance. During the making of the ochre, continuous stirring is required, and yellow ochre is added gradually to allow the yellow ochre to fully react with the oil and ensure that the paste is uniform.

[0026] Pour the refined plaster into the water in a thin stream and stir vigorously to fully dissolve the irritant in the plaster; When the washing water becomes hot, replace it with cold water in time. After it cools and condenses into a mass, immerse the mass in water and change the water several times for about 7 days until the paste has a mild medicinal property. Through the detoxification process, harmful substances in the plaster are effectively removed, ensuring its safety in clinical applications while retaining the effective medicinal properties of the medicinal materials.

[0027] The plaster is spread using a modern and advanced smear machine, and the weight of each plaster is precisely controlled to ensure that the amount of medicinal ingredients contained in each plaster is stable and consistent, thereby ensuring that the medicinal properties of each plaster are uniform and the efficacy is reliable.

[0028] The clinical application of the preparation of Deyu Plaster and the clinical application of Deyu Plaster in treating neck, shoulder, waist and leg pain.

[0029] The test method of application effect: 520 patients were randomly divided into 2 groups, 320 cases in the treatment group, treated with external application of Deyu plaster; 200 cases in the control group, treated with Tongluo Qutong plaster, the course of treatment was 10 days. Results: In the treatment group, 102 cases were cured, 131 cases were markedly effective, 68 cases were effective, and 19 cases were ineffective, with an overall effective rate of 94%; In the control group, 49 cases were cured, 41 cases were markedly effective, 72 cases were effective, 38 cases were ineffective, and the total effective rate was 81%; Conclusion: There was significant difference in the total effective rate between the two groups (p<0.05).

[0030] Clinical symptoms of neck, shoulder, waist, and leg pain include pain, swelling, numbness, and limited limb movement. Early symptoms are atypical, and patients can easily miss the optimal treatment window, impacting prognosis and quality of life. Traditional Chinese Medicine considers neck, shoulder, waist, and leg pain to be a symptom of "arthralgia" and "pain syndrome." Elderly patients experience weakened internal organs, leading to malnutrition and damage to the bones and muscles. Furthermore, external pathogenic wind invades the body, creating a rift between the internal and external forces, leading to blockage of the meridians, stagnation of qi, and blood stasis, manifesting as neck, shoulder, waist, and leg pain.

[0031] In the formula, deer tendon can strengthen the tendons and bones, nourish blood and dredge collaterals, generate essence and marrow, and has remarkable curative effects on long-term rheumatism, joint pain, lumbar and spinal pain, fatigue or weakness of tendons and bones, difficulty in walking, weakness of hands and feet, cramps of hands and feet, traumatic injury and soreness of tendons and bones, etc.; Notopterygium and Angelica pubescens are the main anti-rheumatic drugs in the formula. Notopterygium is good at treating rheumatic arthralgia in the upper body, and Angelica pubescens has a better effect on rheumatic pain in the lower body. The two are used in combination to disperse wind and dampness, dredge the joints, and have a good therapeutic effect on the pain, numbness and other symptoms caused by rheumatic obstruction of collaterals in the neck, shoulders, waist and legs; Honeysuckle has the effects of clearing heat and detoxifying, dispersing wind and heat. On the one hand, it can clear the heat-toxin on the body surface and prevent the rheumatic pathogen from stagnating and transforming into heat. On the other hand, for those with neck, shoulder, waist and leg pain accompanied by local redness, swelling, heat and pain, etc., it can play the role of clearing heat, detumescence and relieving pain, and can restrict the warm and dry nature of other drugs, making the whole formula tonifying without stagnation, warm without dryness; Angelica sinensis is a commonly used drug for activating blood circulation and nourishing blood, and has the effects of activating blood circulation and regulating menstruation, relieving pain and moistening the intestines. It can nourish and activate blood circulation, make qi and blood smooth, and pain will not occur when it is unobstructed, so it can relieve the pain caused by qi and blood stasis in neck, shoulder, waist and leg pain. At the same time, it nourishes blood to moisten the tendons and veins, which helps to improve symptoms such as limb numbness and difficulty in flexion and extension; Fritillaria cirrhosa can clear heat and resolve phlegm, disperse nodules and detumescence. When treating neck, shoulder, waist and leg pain, it can be used to relieve pain, lumps and other symptoms caused by phlegm-dampness blocking collaterals. Compatibility with other drugs helps to disperse local nodules and improve qi and blood circulation; Sophora flavescens can clear heat and dry dampness, kill insects and relieve itching, and can assist honeysuckle to remove damp-heat pathogens. It has a certain relieving effect on symptoms such as joint swelling, heat and pain, and skin itching caused by rheumatic heat arthralgia, and can prevent damp-heat from flowing downward and aggravating the disease; Cinnamon is pungent, sweet and extremely hot, and can tonify fire and assist yang, disperse cold and relieve pain, warm and dredge the meridians. Its warming and dredging power can help drugs such as Angelica sinensis and Notopterygium to better warm and dredge the blood vessels and disperse cold and relieve pain. For neck, shoulder, waist and leg pain caused by cold pathogen stagnation, it can play the role of warming yang and dispelling cold, dredging collaterals and relieving pain, so that the cold pathogen can be dispersed, yang qi can be restored, and qi and blood circulation can be smooth; Orpiment has the effects of detoxifying and promoting granulation, astringing dampness and relieving itching, removing toxins and promoting corrosion when used externally. In the plaster, it can promote local blood circulation, improve tissue nutrition, help the penetration and absorption of drugs, and at the same time has a certain therapeutic effect on local sores, carbuncles and skin breakage, etc., can promote wound healing, reduce pain and inflammatory reaction; Vegetable oil, as the matrix of the plaster, has the functions of moistening the skin and regulating various drugs, enabling various drugs to be evenly mixed, facilitating application and absorption, and at the same time can play a role in protecting the skin and reducing the skin irritation of drugs. The above-mentioned drugs are combined to achieve the effects of expelling wind and dampness, clearing heat and detoxifying, activating blood circulation and relieving pain, relaxing tendons and activating collaterals, dispersing nodules, etc., and have good clinical curative effects on neck, shoulder, waist and leg pain.

[0032] High-efficiency transdermal absorption system: Sesame oil is rich in more than 80% unsaturated fatty acids. During the high-temperature boiling and reaction with orpiment, a micron-level latex particle structure is formed, which greatly increases the specific surface area of drug molecules, enabling it to more effectively improve the transdermal efficiency when contacting the skin. The drug can reach the lesion site faster and deeper, and fully exert its medicinal effect.

[0033] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. The preparation method of Deyu plaster is characterized in that, The proportions of Deyu plaster are as follows: Medicinal materials: Fritillaria (6%); Deer tendon (12%); Honeysuckle (8%); Notopterygium root (6%), Angelica dahurica (4%), Angelica sinensis (8%), Sophora flavescens (12%); Cinnamon bark (8%); Mineral matrix part: yellow lead (12%); Emulsifying base: sesame oil (10%).

2. the preparation method of Deyu large plaster according to claim 1, is characterized in that: The preparation method is as follows: process flow: preparation → boiling → making pills → removing fire poison → slurry → packaging and storage; (1) Preparation: Weigh the Chinese medicinal materials according to the formula and pour them into the decoction pot and soak them in sesame oil for 5-7 days in spring and 7-10 days in autumn and winter; (2) Boiling: Heat the decoction pot to 150℃ and fry the herbs in the decoction pot. Stir the herbs in the decoction pot every half an hour. After 4 hours, raise the temperature of the decoction pot to 220℃. Fry the herbs in the decoction pot until they are dry. Remove the residue. (3) Adding the yellow ochre: Continue to heat the oil in the decocting pot to 300°C, and sprinkle the yellow ochre evenly into the pot. Stir the oil while adding the yellow ochre. (4) Remove fire poison: Pour the medicinal oil from the pill into the water to remove fire poison. Do this for 7 consecutive days, changing the water once a day. (5) Beach application: Melt the ointment for removing fire poison and apply it on the plaster cloth according to the established specifications; (6) Packing and storage.

3. the preparation method of Deyu large plaster according to claim 2, is characterized in that: In its formula, Fritillaria is used to clear heat and moisten the lungs, resolve phlegm and relieve cough; Deer tendon is used to nourish the liver and kidneys and strengthen the bones and muscles; Honeysuckle is used to resist bacteria and reduce inflammation, and dispel wind-heat; Notopterygium and Angelica dahurica are used to dispel wind and dampness, relieve numbness and relieve pain; Angelica and bitter gourd are used to promote blood circulation, nourish blood, dry dampness and detoxify; Cinnamon bark is used to warm the meridians and dispel cold, promoting transdermal absorption; yellow lead is a mineral matrix used to enhance adhesion; sesame oil is used in the emulsified matrix for antioxidant properties.

4. the preparation method of Deyu large plaster according to claim 3, is characterized in that: The specific steps of its preparation are: soaking the medicinal materials in sesame oil as a matrix for 7-10 days; Stone-ground sesame oil not only acts as a solvent, facilitating the dissolution of the active ingredients in the medicinal herbs, but also, due to its unique properties, interacts with the medicinal ingredients during the subsequent refining process, enhancing the efficacy of the plaster. During the soaking process, the active ingredients in the herbs gradually dissolve in the sesame oil, preparing them for subsequent extraction. Precise control of the soaking time is crucial: too short a time will result in inadequate dissolution of the active ingredients; too long a time may cause the ingredients to deteriorate, affecting the quality of the plaster.

5. the preparation method of Deyu large plaster according to claim 2, is characterized in that: The specific steps of its brewing are: after the soaking is completed, it enters the oil refining stage, using soft and hard fire to refine the oil, controlling the heat and time; First, heat to 150°C over a low heat, then continue heating and stirring to allow the sesame oil to blend with the medicinal ingredients and initiate a complex chemical reaction. Then, high heat is used, that is, heating to 220°C, to quickly heat the sesame oil and medicinal materials, so that the water in the sesame oil evaporates quickly and the reaction activity of the medicinal materials and sesame oil is stimulated; The oil is refined until it forms beads. That is, if a drop of oil is dropped into cold water and the oil drop does not disperse but condenses into beads, it indicates that the oil refining has reached the ideal level.

6. the preparation method of Deyu large plaster according to claim 2, is characterized in that: The specific steps of making the oil are as follows: when the oil is refined to a suitable degree, continue to heat it up to 300℃ and add yellow ochre to make the oil; Yellow ochre undergoes a saponification reaction with sesame oil at high temperature, converting the oil into a paste-like substance. During the making of the ochre, continuous stirring is required, and yellow ochre is added gradually to allow the yellow ochre to fully react with the oil and ensure that the paste is uniform.

7. The preparation method of Deyuda plaster according to claim 2, wherein: The specific steps for removing fire poison are as follows: pour the refined plaster into water in a thin stream and stir vigorously to fully dissolve the irritant substances in the plaster; When the washing water becomes hot, replace it with cold water in time. After it cools and condenses into a mass, immerse the mass in water and change the water several times for about 7 days until the paste has a mild medicinal property. Through the detoxification process, harmful substances in the plaster are effectively removed, ensuring its safety in clinical applications while retaining the effective medicinal properties of the medicinal materials.

8. The preparation method of Deyu large plaster according to claim 2, wherein: The specific steps of its application are: using modern advanced application machines to spread the plaster, accurately controlling the weight of each plaster, ensuring that the amount of medicinal ingredients contained in each plaster is stable and consistent, thereby ensuring that the medicinal properties of each plaster are uniform and the efficacy is reliable.

9. The clinical application of the preparation of Deyu large plaster is characterized by: Clinical application of Deyu Plaster in treating neck, shoulder, waist and leg pain.

10. The clinical application of Deyuda plaster according to claim 9, characterized in that: The test method of application effect: 520 patients were randomly divided into 2 groups, 320 cases in the treatment group, treated with external application of Deyu plaster; 200 cases in the control group, treated with Tongluo Qutong plaster, the course of treatment was 10 days. Results: In the treatment group, 102 cases were cured, 131 cases were markedly effective, 68 cases were effective, and 19 cases were ineffective, with an overall effective rate of 94%; In the control group, 49 cases were cured, 41 cases were markedly effective, 72 cases were effective, 38 cases were ineffective, and the total effective rate was 81%; Conclusion: There was significant difference in the total effective rate between the two groups (p<0.05).

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