Ointment for removing blood stasis and eliminating stagnation and preparation method thereof

Abstract

The invention relates to the field of traditional Chinese medicine ointments, in particular to an ointment for removing stasis and eliminating stagnation and a preparation method thereof, and the ointment comprises the following raw materials: solanum melongena, levant cotton root, rheum officinale, ligusticum wallichii, rhizoma drynariae, longan charcoal, scorpion, angelica sinensis, radix paeoniae rubra, radix rehmanniae recen, divaricate saposhnikovia root, fructus forsythiae, notopterygium root, saponin, bletilla striata, castor bean, ginseng, radix sophorae flavescentis, gallnut, radices trichosanthis, coptis chinensis, leavening dough and rice wine. The preparation method comprises the following steps: drying, frying and crushing the raw material medicines, mixing the leavened dough with the rice wine, uniformly stirring, and fermenting for a plurality of hours to obtain the ointment. The problems that a traditional black plaster matrix is prone to generating toxic risks, the release of effective components and the transdermal rate of drugs are affected by using cataplasm, and drugs in some formulas have toxic and side effects are solved.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine ointments, and in particular to an ointment for dispelling blood stasis and dispersing stagnation, and a preparation method thereof. Background Art

[0002] Dispelling stasis and dispersing congestion primarily involves external treatments to alleviate blood stasis and blockages. External conditioning can help alleviate symptoms of blood stasis and blocked meridians, while also promoting blood circulation. Dispelling stasis and dispersing congestion is typically achieved through topical application. Traditional preparation methods destroy over 40% of active ingredients (such as ligustrazine and emodin) at high temperatures. Some formulations also use scorpion venom proteins to enhance efficacy, but these side effects require management, as direct topical application can easily cause local redness and swelling.

[0003] Existing topical ointments for dispersing nodules are mostly in the form of traditional black plasters or cataplexy. The matrix of the black plaster is made of sesame oil, tung oil and red lead. However, this matrix contains heavy metals lead and red lead, which may cause certain side effects and pose a risk of skin toxicity. When using cataplexy, since it is an aqueous matrix, it may affect the release of active ingredients, resulting in insufficient drug concentration gradient and affecting the drug's transdermal rate. Summary of the Invention

[0004] The purpose of the present invention is to provide an ointment for removing blood stasis and dispersing nodules and a preparation method thereof, which solves the problems that the traditional black plaster matrix is ​​prone to toxicity risks, the use of a patch affects the release of active ingredients and the drug transdermal rate, and the drugs in some formulas contain toxic side effects.

[0005] The embodiments of the present invention are achieved through the following technical solutions:

[0006] A medicinal ointment for removing blood stasis and dispersing stagnation, comprising a raw material drug and a matrix, wherein the raw material drug is composed of the following raw materials in parts by weight:

[0007] 32-48 parts of white eggplant roots, 32-48 parts of cotton roots, 64-96 parts of rhubarb, 64-96 parts of chuanxiong, 48-72 parts of drynaria rhizome, 64-96 parts of longan charcoal, 16-24 parts of scorpion, 40-60 parts of angelica, 32-48 parts of red peony root, 40-60 parts of raw rehmannia root, 64-96 parts of siler, 16-24 parts of forsythia, 80-120 parts of notopterygium wilfordii, 24-36 parts of soapberry, 32-48 parts of bletilla striata, 24-36 parts of castor seeds, 16-24 parts of ginseng, 16-24 parts of sophora flavescens, 32-48 parts of gallnut, 24-36 parts of trichosanthes, and 40-60 parts of coptis chinensis.

[0008] The raw material medicine is composed of the following raw materials in parts by weight:

[0009] 40 parts of white eggplant roots, 40 parts of cotton roots, 80 parts of rhubarb, 80 parts of chuanxiong, 60 parts of drynaria rhizome, 80 parts of longan charcoal, 20 parts of scorpions, 50 parts of angelica sinensis, 40 parts of red peony root, 50 parts of raw rehmannia root, 80 parts of siler, 20 parts of forsythia, 100 parts of notopterygium wilfordii, 30 parts of soap beans, 40 parts of bletilla striata, 30 parts of castor beans, 20 parts of ginseng, 20 parts of sophora flavescens, 40 parts of gallnuts, 30 parts of trichosanthes, 50 parts of coptis chinensis.

[0010] The matrix is ​​composed of the following raw materials in parts by mass:

[0011] 880-1320 parts of leavened dough and 320-480 parts of rice wine.

[0012] The matrix is ​​composed of the following raw materials in parts by mass:

[0013] 1100 parts of leavened dough and 400 parts of rice wine.

[0014] A method for preparing an ointment for removing blood stasis and dispersing stagnation comprises the following steps:

[0015] S1. The white eggplant root, cotton root, rhubarb, drynaria, scorpion, angelica, red peony root, raw rehmannia, windproof, forsythia, notopterygium, soap bean, white striata, castor bean, cloud ginseng, sophora flavescens, gallnut, trichosanthes and coptis were dried, and Chuanxiong was fried; longan charcoal was prepared by closed calcination method;

[0016] S2. The raw material after pretreatment in step S1 is crushed to 100-150 mesh;

[0017] S3. The dough is mixed with the raw materials after the crushing step S2, and after stirring, add rice wine and continue stirring;

[0018] S4. After fermentation for 12±0.5 hours, a paste-like ointment can be obtained.

[0019] In step S3, the leavened dough is prepared by fermenting old dough.

[0020] In step S3, the alcohol content of the rice wine is ≥50% vol.

[0021] The technical solutions of the embodiments of the present invention have at least the following advantages and beneficial effects:

[0022] 1. The present invention discloses an ointment for dispelling blood stasis and dispersing stagnation, and its preparation method. By replacing the traditional black plaster matrix with fermented old dough, the risk of heavy metal residues in traditional plasters is eliminated. Furthermore, by adding rice wine, an ethanol esterification reaction is generated therein, thereby increasing the drug's fat solubility. Combined with the nanopores of longan charcoal, the transdermal rate of the drug's active ingredients is increased, thereby enhancing the therapeutic effect.

[0023] 2. The present invention discloses an ointment for removing blood stasis and dispersing stagnation, and a preparation method thereof. To address the problem of scorpion venom in the formula containing toxic side effects, the present invention adopts a drying and inactivation method. This method loosens the conformation of the venom protein through slow dehydration, and utilizes heat denaturation to destroy the scorpion venom protein, thereby increasing the toxin inactivation rate and avoiding the problem of toxic side effects. The ointment retains the active ingredient, analgesic active peptide, and improves the effect of detoxification, dispersing stagnation, and alleviating pain.

[0024] 3. The ointment for removing blood stasis and dispersing nodules of the present invention and the preparation method thereof adopt the step of fermenting Chinese medicine powder mixed with flour. Through the fermentation process of microorganisms, the macromolecular substances in the Chinese medicine are converted into small molecular components. These small molecular components are more easily absorbed by the human body, thereby enhancing the efficacy of the medicine. In addition, the fermentation process can further remove or reduce harmful components in the Chinese medicine, reduce the toxic side effects of the medicine, and make the medicine safer to use. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments.

[0026] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but rather merely represents selected embodiments of the present invention. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without creative effort are intended to fall within the scope of protection of the present invention.

[0027] Example 1

[0028] A medicinal ointment for dispelling blood stasis and dispersing stagnation, comprising the following ingredients: 32g of white eggplant root, 32g of cotton root, 64g of rhubarb, 64g of Chuanxiong, 48g of drynaria rhizome, 64g of longan charcoal, 16g of scorpion, 40g of angelica sinensis, 32g of red peony root, 40g of raw rehmannia root, 64g of siler, 16g of forsythia, 80g of notopterygium wilfordii, 24g of soapberry, 32g of bletilla striata, 24g of castor bean, 16g of ginseng, 16g of sophora flavescens, 32g of gallnut, 24g of trichosanthes root, 40g of coptis chinensis, 880g of leavened dough, and 320g of rice wine;

[0029] A method for preparing an ointment for removing blood stasis and dispersing stagnation comprises the following steps:

[0030] S1. The white eggplant root, cotton root, rhubarb, drynaria, scorpion, angelica, red peony root, raw rehmannia, windproof, forsythia, notopterygium, soap bean, white striata, castor bean, cloud ginseng, sophora flavescens, gallnut, trichosanthes and coptis were dried, and Chuanxiong was fried; longan charcoal was prepared by closed calcination method;

[0031] Specifically, the scorpions were dried in sections. First, they were placed in a 40°C environment for 2 hours to slowly dehydrate and loosen the toxin protein conformation. Then, they were placed in a 60°C environment for 4 hours to destroy the disulfide bonds of the scorpion venom protein through heat denaturation. This increased the toxin inactivation rate and avoided the toxic side effects of the scorpion venom protein.

[0032] Specifically, the longan pulp is spread flat on a crucible with a thickness of ≤5 cm; then covered with a double layer of straw paper to seal, and the outer layer is sealed with yellow mud; the crucible is placed on a smokeless charcoal fire and calcined at a temperature of 300±20°C for 4-6 hours until the interior is completely carbonized to obtain longan charcoal;

[0033] More specifically, longan charcoal can be made by thermally decomposing polysaccharides to generate activated carbon, thereby enhancing the adsorption and astringency effect.

[0034] S2. The raw material after pretreatment in step S1 is crushed to 100 mesh and set aside; the mesh size of the powder in this range allows the ointment to have good viscosity and uniformity, ensuring a reasonable distribution of the drug in the plaster, and enabling continuous and stable efficacy during application;

[0035] S3. The dough is mixed with the raw materials after the crushing step S2, and after stirring, more than 50% vol rice wine is added and continued stirring to enhance the fermentation effect;

[0036] When making dough, it is preferably made by fermenting old dough, which has a higher content of microorganisms and is conducive to the microbial fermentation process, so that the macromolecular substances in the traditional Chinese medicine are converted into small molecular components. These small molecular components are more easily absorbed by the human body, thereby enhancing the efficacy of the medicine;

[0037] 50% vol ethanol can dissolve the cell membrane lipids of most spoilage bacteria (such as Escherichia coli and Staphylococcus aureus); and the dominant bacteria in old noodles (such as Lactobacillus plantarum) have strong tolerance to ethanol and will not affect the normal preparation process;

[0038] S4. After fermentation for 12±0.5 hours, a paste-like ointment can be obtained.

[0039] Example 2

[0040] A medicinal ointment for dispelling blood stasis and dispersing stagnation, comprising the following ingredients: 40g of white eggplant root, 40g of cotton root, 80g of rhubarb, 80g of Chuanxiong, 60g of drynaria rhizome, 80g of longan charcoal, 20g of scorpion, 50g of angelica sinensis, 40g of red peony root, 50g of raw rehmannia root, 80g of siler, 20g of forsythia, 100g of notopterygium wilfordii, 30g of soapberry, 40g of bletilla striata, 30g of castor bean, 20g of ginseng, 20g of sophora flavescens, 40g of gallnut, 30g of trichosanthes root, 50g of coptis chinensis, 1100g of leavened dough, and 400g of rice wine;

[0041] A method for preparing an ointment for removing blood stasis and dispersing stagnation comprises the following steps:

[0042] S1. The white eggplant root, cotton root, rhubarb, drynaria, scorpion, angelica, red peony root, raw rehmannia, windproof, forsythia, notopterygium, soap bean, white striata, castor bean, cloud ginseng, sophora flavescens, gallnut, trichosanthes and coptis were dried, and Chuanxiong was fried; longan charcoal was prepared by closed calcination method;

[0043] Specifically, the scorpions were dried in sections. First, they were placed in a 40°C environment for 2 hours to slowly dehydrate and loosen the toxin protein conformation. Then, they were placed in a 60°C environment for 4 hours to destroy the disulfide bonds of the scorpion venom protein through heat denaturation. This increased the toxin inactivation rate and avoided the toxic side effects of the scorpion venom protein.

[0044] Specifically, the longan pulp is spread flat on a crucible with a thickness of ≤5 cm; then covered with a double layer of straw paper to seal, and the outer layer is sealed with yellow mud; the crucible is placed on a smokeless charcoal fire and calcined at a temperature of 300±20°C for 4-6 hours until the interior is completely carbonized to obtain longan charcoal;

[0045] More specifically, longan charcoal can be made by thermally decomposing polysaccharides to generate activated carbon, thereby enhancing the adsorption and astringency effect.

[0046] S2. The raw material after pretreatment in step S1 is crushed to 125 mesh and set aside; the mesh size of the powder in this range allows the ointment to have good viscosity and uniformity, ensuring a reasonable distribution of the drug in the plaster, and enabling continuous and stable efficacy during application;

[0047] S3. The dough is mixed with the raw materials after the crushing step S2, and after stirring, more than 50% vol rice wine is added and continued stirring to enhance the fermentation effect;

[0048] When making dough, it is preferably made by fermenting old dough, which has a higher content of microorganisms and is conducive to the microbial fermentation process, so that the macromolecular substances in the traditional Chinese medicine are converted into small molecular components. These small molecular components are more easily absorbed by the human body, thereby enhancing the efficacy of the medicine;

[0049] 50% vol ethanol can dissolve the cell membrane lipids of most spoilage bacteria (such as Escherichia coli and Staphylococcus aureus); and the dominant bacteria in old noodles (such as Lactobacillus plantarum) have strong tolerance to ethanol and will not affect the normal preparation process;

[0050] S4. After fermentation for 12±0.5 hours, a paste-like ointment can be obtained.

[0051] Example 3

[0052] A medicinal ointment for dispelling blood stasis and dispersing stagnation, comprising the following ingredients: 48g of white eggplant root, 48g of cotton root, 96g of rhubarb, 96g of Chuanxiong, 72g of drynaria rhizome, 96g of longan charcoal, 24g of scorpion, 60g of angelica sinensis, 48g of red peony root, 60g of raw rehmannia root, 96g of siler, 24g of forsythia, 120g of notopterygium wilfordii, 36g of soapberry, 48g of bletilla striata, 36g of castor bean, 24g of ginseng, 24g of sophora flavescens, 48g of gallnut, 36g of trichosanthes root, 60g of coptis chinensis, 1320g of leavened dough, and 480g of rice wine;

[0053] A method for preparing an ointment for removing blood stasis and dispersing stagnation comprises the following steps:

[0054] S1. The white eggplant root, cotton root, rhubarb, drynaria, scorpion, angelica, red peony root, raw rehmannia, windproof, forsythia, notopterygium, soap bean, white striata, castor bean, cloud ginseng, sophora flavescens, gallnut, trichosanthes and coptis were dried, and Chuanxiong was fried; longan charcoal was prepared by closed calcination method;

[0055] Specifically, the scorpions were dried in sections. First, they were placed in a 40°C environment for 2 hours to slowly dehydrate and loosen the toxin protein conformation. Then, they were placed in a 60°C environment for 4 hours to destroy the disulfide bonds of the scorpion venom protein through heat denaturation. This increased the toxin inactivation rate and avoided the toxic side effects of the scorpion venom protein.

[0056] Specifically, the longan pulp is spread flat on a crucible with a thickness of ≤5 cm; then covered with a double layer of straw paper to seal, and the outer layer is sealed with yellow mud; the crucible is placed on a smokeless charcoal fire and calcined at a temperature of 300±20°C for 4-6 hours until the interior is completely carbonized to obtain longan charcoal;

[0057] More specifically, longan charcoal can be made by thermally decomposing polysaccharides to generate activated carbon, thereby enhancing the adsorption and astringency effect.

[0058] S2. The raw material after pretreatment in step S1 is crushed to 150 mesh and set aside; the mesh size of the powder in this range allows the ointment to have good viscosity and uniformity, ensuring a reasonable distribution of the drug in the plaster, and enabling continuous and stable efficacy during application;

[0059] S3. The dough is mixed with the raw materials after the crushing step S2, and after stirring, more than 50% vol rice wine is added and continued stirring to enhance the fermentation effect;

[0060] When making dough, it is preferably made by fermenting old dough, which has a higher content of microorganisms and is conducive to the microbial fermentation process, so that the macromolecular substances in the traditional Chinese medicine are converted into small molecular components. These small molecular components are more easily absorbed by the human body, thereby enhancing the efficacy of the medicine;

[0061] 50% vol ethanol can dissolve the cell membrane lipids of most spoilage bacteria (such as Escherichia coli and Staphylococcus aureus); and the dominant bacteria in old noodles (such as Lactobacillus plantarum) have strong tolerance to ethanol and will not affect the normal preparation process;

[0062] S4. After fermentation for 12±0.5 hours, a paste-like ointment can be obtained.

[0063] Clinical trial group 1

[0064] Yang, a 37-year-old female, suffered from gout, which caused her fingers to become stiff and painful and unable to exert force.

[0065] The ointment prepared in Example 1 was evenly applied to the meridian reflex points on the palm of the patient with a thickness of about 2 mm, and then covered with sterile gauze, impermeable plastic film and elastic bandage in sequence; the single application time was 12 hours per day, and the medicine was changed for a course of 3 weeks, and the effect was observed regularly every week;

[0066] At the end of the first week, the patient showed significant improvement, with reduced symptoms, no adverse reactions at the application site, and no changes in skin condition;

[0067] At the end of the second week, the patient's symptoms continued to improve, with no obvious soreness or pain in the fingers, and no adverse reactions at the application site;

[0068] At the end of the third week, the patient's symptoms completely disappeared, his fingers moved smoothly, and there were no adverse reactions at the applied area.

[0069] Clinical trial group 2

[0070] Wang, an 80-year-old female, was afraid to walk due to arthritis pain. She also applied the ointment prepared in Example 1 evenly to the meridian reflex points on the soles of her feet. The thickness was

[0071] The wound is about 3mm long, and then covered with sterile gauze, impermeable plastic film and elastic bandage in sequence; the single application time is 12 hours a day, the medicine is changed, and the treatment course lasts for 2 weeks, and the effect is regularly observed every three days;

[0072] At the end of the first week, the patient showed significant improvement, the foot effusion was eliminated and the symptoms were alleviated, there was no adverse reaction at the application site, and the skin condition did not change;

[0073] At the end of the second week, the pain was gone, the swelling had completely subsided, and there were no adverse reactions at the applied area.

[0074] Clinical trial group 3

[0075] Xu, a 19-year-old male, was accidentally hit by a tennis ball while playing;

[0076] The ointment prepared in Example 3 was evenly applied to the meridian reflex points of the patient's arm injury with a thickness of about 5 mm, and then covered with sterile gauze, impermeable plastic film and elastic bandage in sequence; the ointment was changed every 12 hours for a 2-week course of treatment, and the effect was observed regularly every three days;

[0077] At the end of the first week, the patient showed significant improvement, with reduced pain symptoms and no adverse reactions at the applied site;

[0078] At the end of the second week, the patient's symptoms completely disappeared, his arm moved smoothly, and there were no adverse reactions at the applied area.

[0079] Summary of clinical experiments: The ointment for removing blood stasis and dispersing stagnation of the present invention has a good therapeutic effect, which is generally effective in about 1 week, and the symptoms are significantly improved in about 2-3 weeks. It does not have the risk of heavy metal residues found in traditional plasters, and has no adverse reactions at the skin contact site. Compared with the use of black plaster as a matrix for coating, which is prone to lead poisoning, the ointment of the present invention uses leavened dough as a matrix, which can greatly reduce the impact of drug toxicity on patients.

[0080] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Those skilled in the art will readily appreciate that the present invention is susceptible to various modifications and variations. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A medicinal ointment for removing blood stasis and dispersing stagnation, characterized in that: Including API and matrix, the API is composed of the following raw materials in parts by weight: 32-48 parts of white eggplant roots, 32-48 parts of cotton roots, 64-96 parts of rhubarb, 64-96 parts of chuanxiong, 48-72 parts of drynaria rhizome, 64-96 parts of longan charcoal, 16-24 parts of scorpion, 40-60 parts of angelica, 32-48 parts of red peony root, 40-60 parts of raw rehmannia root, 64-96 parts of siler, 16-24 parts of forsythia, 80-120 parts of notopterygium wilfordii, 24-36 parts of soapberry, 32-48 parts of bletilla striata, 24-36 parts of castor seeds, 16-24 parts of ginseng, 16-24 parts of sophora flavescens, 32-48 parts of gallnut, 24-36 parts of trichosanthes, and 40-60 parts of coptis chinensis.

2. The ointment for removing blood stasis and dispersing stagnation according to claim 1, characterized in that: The raw material medicine is composed of the following raw materials in parts by weight: 40 parts of white eggplant roots, 40 parts of cotton roots, 80 parts of rhubarb, 80 parts of chuanxiong, 60 parts of drynaria rhizome, 80 parts of longan charcoal, 20 parts of scorpions, 50 parts of angelica sinensis, 40 parts of red peony root, 50 parts of raw rehmannia root, 80 parts of siler, 20 parts of forsythia, 100 parts of notopterygium wilfordii, 30 parts of soap beans, 40 parts of bletilla striata, 30 parts of castor beans, 20 parts of ginseng, 20 parts of sophora flavescens, 40 parts of gallnuts, 30 parts of trichosanthes, 50 parts of coptis chinensis.

3. The ointment for removing blood stasis and dispersing stagnation according to claim 1, characterized in that: The matrix is ​​composed of the following raw materials in parts by mass: 880-1320 parts of leavened dough and 320-480 parts of rice wine.

4. The ointment for removing blood stasis and dispersing stagnation according to claim 3, characterized in that: The matrix is ​​composed of the following raw materials in parts by mass: 1100 parts of leavened dough and 400 parts of rice wine.

5. A method for preparing the ointment for removing blood stasis and dispersing stagnation according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1. The white eggplant root, cotton root, rhubarb, drynaria, scorpion, angelica, red peony root, raw rehmannia, windproof, forsythia, notopterygium, soap bean, white striata, castor bean, cloud ginseng, sophora flavescens, gallnut, trichosanthes and coptis were dried, and Chuanxiong was fried; longan charcoal was prepared by closed calcination method; S2. The raw material after pretreatment in step S1 is crushed to 100-150 mesh; S3. The dough is mixed with the raw materials after the crushing step S2, and after stirring, add rice wine and continue stirring; S4. After fermentation for 12±0.5 hours, a paste-like ointment can be obtained.

6. The method for preparing the ointment for removing blood stasis and dispersing stagnation according to claim 5, characterized in that: In step S3, the leavened dough is prepared by fermenting old dough.

7. The method for preparing the ointment for removing blood stasis and dispersing stagnation according to claim 5, characterized in that: In step S3, the alcohol content of the rice wine is ≥50% vol.